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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PPIB Gene

protein-coding GIFtS: 72
GCID: GC15M064448

peptidylprolyl isomerase B (cyclophilin B)

Explore 19 diseases affiliated with
PPIB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Peptidylprolyl Isomerase B (Cyclophilin B)¹ ²		SCYLP² ³
CYPB¹ ² ³ ⁵		PPIase B² ³
OI9¹ ² ⁵		EC 5.2.1.8³ ⁸
Rotamase B² ³		Cyclophilin-Like Protein²
CYP-S1² ³		Peptidyl-Prolyl Cis-Trans Isomerase B²
S-Cyclophilin¹		Cyclophilin B³

External Ids:	HGNC: 9255¹	Entrez Gene: 5479²	Ensembl: ENSG00000166794⁷	OMIM: 123841⁵	UniProtKB: P23284³

Export aliases for PPIB gene to outside databases

Previous GC identifers: GC15M060234 GC15M057607 GC15M062026 GC15M062163 GC15M062235 GC15M041272

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPIB:

The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic

reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to

cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have

been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. (provided by RefSeq, Oct

2009)

UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284

Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic

peptide bonds in oligopeptides

Gene Wiki entry for PPIB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PPIB gene promoter:
Bach1 AP-1 Tal-1 E47 AREB6 FAC1 Pax-3 Hand1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPIB promoter sequence

Search SABiosciences Chromatin IP Primers for PPIB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21-q22 Ensembl cytogenetic band: 15q22.31 HGNC cytogenetic band: 15q21-q22

PPIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIB gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M064448: view genomic region (about GC identifiers)

Start:	64,448,011 bp from pter	End:	64,455,404 bp from pter
Size:	7,394 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284 (See protein sequence)

Recommended Name: Peptidyl-prolyl cis-trans isomerase B precursor

Size: 216 amino acids; 23743 Da

Subunit: Interacts with DYM

Subcellular location: Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome

fractions from stage I to stage IV

Caution: It is uncertain whether Met-1 or Met-9 is the initiator

Sequence caution: Sequence=AAA52150.1; Type=Erroneous initiation;

3 PDB 3D structures from and Proteopedia for PPIB:

1CYN (3D)

3ICH (3D)

3ICI (3D)

Secondary accessions: A8K534 Q6IBH5 Q9BVK5

Explore the universe of human proteins at neXtProt for PPIB: NX_P23284

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P23284

4/10 DME Specific Peptides for PPIB (P23284) (see all 10)

GGKSIYG

FMIQGGD

GKTVPKT

TNGSQFF

PPIB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000933.1

ENSEMBL proteins:

ENSP00000300026

Reactome Protein details: P23284
Human Recombinant Protein Products:

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	Novus Biologicals PPIB Proteins Novus Biologicals PPIB Lysate
	Sino Biological Recombinant Protein for PPIB
	ProSpec Recombinant Protein for PPIB
	Uscn Proteins for PPIB

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	TAS	2000394
GO:0005788	endoplasmic reticulum lumen	TAS	--
GO:0042470	melanosome	IEA	--

PPIB for ontologies About GeneDecksing

PPIB Antibody Products:

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	ThermoFisher Antibody for PPIB

Assay Products for PPIB:

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	Uscn ELISAs and CLIAs for PPIB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PPIB for domains About GeneDecksing

3 InterPro domains/families:

IPR002130 Cyclophilin-like_PPIase_dom

IPR024936 Cyclophilin-type_PPIase

IPR020892 Cyclophilin-type_PPIase_CS

Graphical View of Domain Structure for InterPro Entry P23284

ProtoNet protein and cluster: P23284

1 Blocks protein family: IPB002130 Peptidyl-prolyl cis-trans isomerase

UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284

Similarity: Belongs to the cyclophilin-type PPIase family. PPIase B subfamily

Similarity: Contains 1 PPIase cyclophilin-type domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284

Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic

peptide bonds in oligopeptides

Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

Enzyme regulation: Cyclosporin A (CsA) inhibits CYPB

Genatlas biochemistry entry for PPIB:

peptidyl-propyl isomerase B

Enzyme Number (IUBMB): EC 5.2.1.8¹ ²

miRNA Products:		miRTarBase miRNAs that target PPIB: hsa-mir-1 (MIRT001347)

		OriGene 3'-UTR Clone: PPIB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPIB
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIB:
		hsa-miR-206 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-613 hsa-miR-1
		SwitchGear 3'UTR luciferase reporter plasmid: PPIB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPIB (see all 7) OriGene shRNA RFP: PPIB OriGene siRNA: PPIB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIB

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PPIB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: PPIB (NM_000942)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PPIB
		Search LifeMap BioReagents cell lines for PPIB

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PPIB

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	NAS	2000394
GO:0005515	protein binding	IPI	15095401
GO:0042277	peptide binding	IEA	--
GO:0051082	unfolded protein binding	TAS	2000394

PPIB for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for PPIB:

Increased G1 DNA content

Increased HPV18 LCR reporter a

Wnt reporter downregulated

Animal Models:
Mouse knock-out Ppib^tm1.1Rjb for PPIB
5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ppib):

growth/size

integument

mortality/aging

no phenotypic analysis

skeleton

PPIB for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Collagen formation

	Collagen formation	1.00			Extracellular matrix organization	0.54
	Collagen biosynthesis and modifying enzymes	0.74

BAFF in B-Cell Signaling

Apoptosis and survival_APRIL and BAFF signaling

0.39

Apoptosis and survival APRIL and BAFF signaling

0.39

Syndecan-1-mediated signaling events

Syndecan-1-mediated signaling events

1.00

Development_Prolactin receptor signaling

Prolactin Signaling Pathway

0.39

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PPIB

Apoptosis and survival APRIL and BAFF signaling

1 GeneGo (Thomson Reuters) Pathway for PPIB

Apoptosis and survival APRIL and BAFF signaling

2 BioSystems Pathways for PPIB

	Prolactin Signaling Pathway
	Syndecan-1-mediated signaling events

3 Reactome Pathways for PPIB

	Extracellular matrix organization
	Collagen biosynthesis and modifying enzymes
	Collagen formation

PPIB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PPIB

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/55 Interacting proteins for PPIB (P23284^{2, 3} ENSP00000300026⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 55)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRAF1	Q13077²^,³	MINT-49520 I2D: score=2
UBQLN4	Q9NRR5²^,³, ENSP00000357292⁴	MINT-2861854 I2D: score=3 STRING: ENSP00000357292
DNM2	P50570³, ENSP00000352721⁴	I2D: score=3 STRING: ENSP00000352721
APOB	P04114³, ENSP00000233242⁴	I2D: score=2 STRING: ENSP00000233242
USP21	Q9UK80³, ENSP00000289865⁴	I2D: score=2 STRING: ENSP00000289865

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000413	protein peptidyl-prolyl isomerization	NAS	2000394
GO:0006457	protein folding	IEA	--
GO:0030198	extracellular matrix organization	TAS	--

PPIB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PPIB for compounds About GeneDecksing

EMD Millipore small molecules for PPIB:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PPIB

1 HMDB Compound for PPIB About this table

Compound	Synonyms	CAS #	PubMed Ids
L-Proline	(-)-(S)-Proline (see all 16)	147-85-3	--

2 DrugBank Compounds for PPIB About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Proline	(-)-2-Pyrrolidinecarboxylic acid (see all 6)	147-85-3	target	binder	17139284 11752352 17016423
1,4-Dithiothreitol	--	--	target	--	10592235

5 Novoseek chemical compound relationships for PPIB gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cyclosporin a	69.9	42	9378502 (4), 10386979 (4), 8713086 (3), 11955071 (2) (see all 19)
heparan sulfate	56.2	21	19940140 (4), 17588944 (4), 15109301 (4)
proline	38.6	5	19781681 (2), 17630507 (1)
anti-fungal	24.4	3	15245883 (1), 11848297 (1), 11732686 (1)
heparin	22.8	6	15109301 (4), 19940140 (1)

Search CenterWatch for drugs/clinical trials and news about PPIB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PPIB gene:

NM_000942.4

Unigene Cluster for PPIB:

Peptidylprolyl isomerase B (cyclophilin B)

Hs.434937 [show with all ESTs]

Unigene Representative Sequence: BQ049986

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000300026(uc002and.3) ENST00000558492 ENST00000561048(uc010bgx.1)

miRNA Products:		OriGene 3'-UTR Clone: PPIB Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPIB
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIB:
		hsa-miR-206 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-613 hsa-miR-1
		SwitchGear 3'UTR luciferase reporter plasmid: PPIB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPIB (see all 7) OriGene shRNA RFP: PPIB OriGene siRNA: PPIB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIB

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIB (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIB OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PPIB (NM_000942)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPIB Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIB

Additional cDNA sequence:

AK291149.1 AK311074.1 BC001125.2 BC008848.2 BC020800.1 BC032138.2 CR456829.1 M60457.1

M60857.1 M63573.1

24/30 DOTS entries (see all 30):

DT.95344633 DT.100845917 DT.119195 DT.95352178 DT.100845915 DT.100845910 DT.95352206 DT.101985571

DT.97784070 DT.100845912 DT.100845914 DT.100845919 DT.95237355 DT.100845913 DT.121023162 DT.121023414

DT.92068163 DT.92457228 DT.95352171 DT.121023234 DT.121023413 DT.121023420 DT.92457220 DT.95147920

24/953 AceView cDNA sequences (see all 953):

CF552399 AJ712593 BP338061 BM831044 BM741113 BM785350 BM802364 BM756176

BM969712 BM781952 BM830826 BM848965 BI768795 BX335040 BU507664 BQ637087

BM503216 BM848839 BM747383 CA843061 BI823156 BU623904 BM825548 BQ439218

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for PPIB About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5a	·	5b
SP1:											-
SP2:							-				-
SP3:

ECgene alternative splicing isoforms for PPIB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPIB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTCACTTT

About this image

PPIB expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Endochondral Facial Bones

Bone

Rostral Endochondral Facial Bones

Bone

Rostral Skull Membranous Bones

Bone

Bone

Cartilage

Cartilage

Rostral Chondrocranium

Cartilage

Rostral Synchondroses

Cartilage

Synchondroses

Cartilage

Head Mesenchyme

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PPIB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPIB

SOURCE GeneReport for Unigene cluster: Hs.434937

SABiosciences Custom PCR Arrays for PPIB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPIB Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIB

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PPIB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIB gene from 36 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chimpanzee (Pan troglodytes)	Mammalia	PPIB¹	peptidylprolyl isomerase B (cyclophilin B)	99.85(n) 99.54(a)		747801 XM_003314707.2 XP_003314755.1
mouse (Mus musculus)	Mammalia	Ppib^{1 , 5}	peptidylprolyl isomerase B^{1, 5}	90.12(n)¹ 93.98(a)¹		9 (35.69 cM)⁵ 19035¹ NM_011149.2¹ NP_035279.2¹ 66060169⁵
rat (Rattus norvegicus)	Mammalia	Ppib¹	peptidylprolyl isomerase B	89.1(n) 93.27(a)		64367 NM_022536.1 NP_071981.1
cow (Bos taurus)	Mammalia	PPIB¹	peptidylprolyl isomerase B (cyclophilin B)	90.22(n) 93.75(a)		281419 NM_174152.2 NP_776577.1
dog (Canis familiaris)	Mammalia	PPIB¹	peptidylprolyl isomerase B (cyclophilin B)	90.59(n) 95.83(a)		478337 XM_847296.2 XP_852389.1
oppossum (Monodelphis domestica)	Mammalia	PPIB⁶	Peptidyl-prolyl cis-trans isomerase	86(a)	1 ↔ 1	1(149778078-149786181)
platypus (Ornithorhynchus anatinus)	Mammalia	PPIB⁶	Peptidyl-prolyl cis-trans isomerase	89(a)	1 ↔ 1	Ultra122(1714-11400)
chicken (Gallus gallus)	Aves	PPIB¹	peptidylprolyl isomerase B (cyclophilin B)	80.84(n) 86.47(a)		396447 NM_205461.1 NP_990792.1
lizard (Anolis carolinensis)	Reptilia	PPIB⁶	--	83(a)	1 ↔ 1	GL343490.1(417575-422070)
African clawed frog (Xenopus laevis)	Amphibia	ppib-prov²	peptidylprolyl isomerase B	76.63(n)		BC054168.1
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.806²	Transcribed sequence with moderate similarity to protein more	77.51(n)		CF781675.1
zebrafish (Danio rerio)	Actinopterygii	wufa97f08²	Danio rerio cDNA clone MGC73214 IMAGE4790964, complete more	79.36(n)		BC059560.1
rainbow trout (Oncorhynchus mykiss)	Actinopterygii	Omy.8306²	Oncorhynchus mykiss transcribed sequence with moderate more	81.31(n)		BX073914.1
sea squirt (Ciona savignyi)	Ascidiacea	-- -- (see all 4)	--	71(a) 55(a) (see all 4)	possible ortholog possible ortholog (see all 4)	reftig_1383(6801-7412) reftig_54(3497882-3500183)
sea urchin (Strongylocentrotus purpuratus)	Echinoidea	-- -- (see all 3)	--	69(a) 68(a) (see all 3)	many ↔ many many ↔ many (see all 3)	scaffold_187(546291-558579) scaffold_187(569285-580878)
fruit fly (Drosophila melanogaster)	Insecta	CG2852^{1 , 3}	peptidyl-prolyl cis-trans isomerase³ CG2852¹	73(a) (best of 2)³ 68.17(n)¹ 67.5(a)¹		58F3³ 37591¹ NM_137851.3¹ NP_611695.1¹
mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP007088¹	AGAP007088-PA	65.62(n) 70.68(a)		1270014 XM_308669.4 XP_308669.2
honey bee (Apis mellifera)	Insecta	-- --	--	63(a) 43(a)	1 ↔ many possible ortholog	GroupUn.26(111814-112988) Group13.7(454083-455992)
worm (Caenorhabditis elegans)	Secernentea	cyp-5³ cyn-5¹	cyclophillin³ Protein CYN-5¹	71(a) (best of 4)³ 63.35(n)¹ 67.66(a)¹		I(15048595-15049564)³ 173374¹ NM_061223.4¹ NP_493624.1¹
schistosome parasite (Schistosoma mansoni)	Trematoda	CYP⁶	Peptidyl-prolyl cis-trans isomerase B	59(a)	1 → many	Smp_scaff000100(411126-412066)
common water flea (Daphnia pulex)	Crustacea	-- --	--	66(a) 50(a)	1 ↔ many possible ortholog	scaffold_1(2412580-2413543) scaffold_131(332268-333548)
Trichoplax (Trichoplax adhaerens)	Tricoplacia	-- --	--	70(a) 67(a)	possible ortholog possible ortholog	scaffold_3(4175195-4178895) scaffold_3(4181617-4184440)
sea anemone (Nematostella vectensis)	Anthozoa	-- -- (see all 3)	--	67(a) 66(a) (see all 3)	possible ortholog possible ortholog (see all 3)	scaffold_218(229315-232254) scaffold_218(225659-228582)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CPR5(YDR304C)⁴ CPR5¹	Peptidyl-prolyl cis-trans isomerase (cyclophilin) of more⁴ Cpr5p¹	55.85(n)¹ 56.38(a)¹		4(1072557-1071880)⁴ 851898^{1, 4} NP_010590.3¹ NP_010590.1⁴
A. gossypii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_AAL056C¹	AAL056Cp	59.08(n) 60.48(a)		4618645 NM_207839.1 NP_982486.1
K. lactis yeast (Kluyveromyces lactis)	Saccharomycetes	KLLA0C10208g¹	hypothetical protein	58.09(n) 60.23(a)		2892230 XM_452654.1 XP_452654.1
fission yeast (Schizosaccharomyces pombe)	Schizosaccharomycetes	cyp4¹	cyclophilin family peptidyl-prolyl cis-trans isomerase more	61.26(n) 68.11(a)		2541395 NP_596532.1
bread mold (Neurospora crassa)	Ascomycetes	NCU01200¹	peptidyl-prolyl cis-trans isomerase B precursor	65.98(n) 69.43(a)		5847555 XM_001728253.1 XP_001728305.1
stem rust fungus (Puccinia graminis)	Pucciniomycetes	PGTG_08352⁶	peptidyl-prolyl cis-trans isomerase B (cyclophilin...	40(a)	1 → many
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G55920¹	peptidyl-prolyl cis-trans isomerase	61.62(n) 65.45(a)		824758 NM_115450.3 NP_567029.1
soybean (Glycine max)	eudicotyledons	BI945934.1²	--	73.01(n)		BI945934.1
rice (Oryza sativa)	Liliopsida	AK104772.1²	--	75.26(n)		AK104772.1
barley (Hordeum vulgare)	Liliopsida	BJ447859.1²	--	73.22(n)		BJ447859.1
corn (Zea mays)	Liliopsida	BI416980.1²	--	74.43(n)		BI416980.1
wheat (Triticum aestivum)	Liliopsida	Ta.28895²	Triticum aestivum cyclophilin-like protein (Cyp-26a) more	72.71(n)		AY217751.1
green algae (Chlamydomonas reinhardtii)	Chlorophyceae	CYN20-3⁶ CYN20-2⁶	peptidyl-prolyl cis-trans isomerase, cyclophilin-t... peptidyl-prolyl cis-trans isomerase, cyclophilin-t...	57(a) 44(a)	many ↔ many many ↔ many	DS496163(2879-6067) DS496127(509833-512447)

Species with no ortholog for PPIB

ENSEMBL Gene Tree for PPIB (if available)
TreeFam Gene Tree for PPIB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PPIB gene

CWC27² PPIL4² PPWD1² PPIL3² PPIH² PPIC² PPIL1² PPIL2²

18/22 SIMAP similar genes for PPIB using alignment to 1 protein entry: PPIB_HUMAN(see all similar genes):

PPIC PPIA PPIE PPIF PPIH LOC402252

RANBP2 PPIL1 PPID PPIAL4A PPIAL4B PPIAL4C

PPIAL4G PPIG NKTR PPWD1 PPIL3 PPIL6

PPIB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121434559^1,2	C	pathogenic	64449001(-)	`GCTCCC/TAGTTC`	3	Q *	stg¹ ut3¹		0	--	--	--	--
rs137853864^1,2	C	pathogenic	64455160(-)	`CAACAG/TGAAGG`	2	R M	mis¹		0	--	--	--	--
rs28720193^1,2	C	untested	64448960(-)	`GATGGC/GAAGCA`	3	G	syn¹ ut3¹		5		NS	188
rs2307247^1,2	C,F,H,	untested	64452322(-)	`TTCACC/TAGGGG`	2	T	syn¹ ese³		12		NA NS EU	6725
rs11558595^1,2	C,F,H	untested	64454311(-)	`GCCGGG/TTGATC`	2	V L	mis¹ ese³		9		NS EA NA	762
rs4904^1,2	C,F,H,	untested	64455123(-)	`GGGTCC/AGTCTT`	2	/S	syn¹ ese³		18		MN EA NS WA NA EU	7035
rs181848744^1,2		--	64447594(+)	`GTCAGC/GTGGGT`	2	--	ds500¹ ut3¹		0	--	--	--	--
rs3896787^1,2	H	--	64447742(+)	`ATTTAG/AAGGTA`	2	--	ds500¹ ut3¹		5		MN NS EA	562
rs186457893^1,2		--	64447773(+)	`ACATCA/CCTTAA`	2	--	ut3¹ ds500¹		0	--	--	--	--
rs3858911^1,2	C,H	--	64447783(+)	`ACATAG/AACTGG`	2	--	ds500¹ ut3¹		5		MN NS EA	602

HapMap Linkage Disequilibrium report for PPIB (64448011 - 64455404 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PPIB: --
Human Gene Mutation Database (HGMD): PPIB

Locus Specific Mutation Databases (LSDB): PPIB

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPIB

DNA2.0 Custom Variant and Variant Library Synthesis for PPIB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PPIB for disorders           About GeneDecksing

OMIM gene information: 123841
OMIM disorders: 259440
UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284

Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9) [MIM:259440]. OI9 is a connective tissue

disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb

dwarfism and blue sclerae are observed in some but not all patients

19 diseases for PPIB: About MalaCards

osteogenesis imperfecta osteogenesis imperfecta type 9 dentinogenesis imperfecta connective tissue disease

syphilis dwarfism nephrotic syndrome multiple myeloma

hepatitis c encephalitis myeloma hepatocellular carcinoma

breast cancer ataxia hepatitis immunodeficiency

carcinoma pancreatitis malaria

1 disease from the University of Copenhagen DISEASES database for PPIB:

Osteogenesis imperfecta

Human Genome Epidemiology (HuGE) Navigator: PPIB (1 document)

Export disorders for PPIB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PPIB gene, integrated from 9 sources (see all 110):
(articles sorted by number of sources associating them with PPIB)

Utopia: connect your pdf to the dynamic
world of online information

Human cyclophilin B: a second cyclophilin gene encodes a peptidyl- prolyl isomerase with a signal sequence. (PubMed id 2000394)^{1, 2, 3, 9} Price E.R....Walsh C.T. (1991)
Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding. (PubMed id 20089953)^{1, 2, 3, 9} Barnes A.M....Marini J.C. (2010)
PPIB mutations cause severe osteogenesis imperfecta. (PubMed id 19781681)^{1, 2, 9} van Dijk F.S.... Pals G. (2009)
A novel secreted cyclophilin-like protein (SCYLP). (PubMed id 2040592)^{1, 2, 9} Spik G.... Movva N.R. (1991)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{1, 2} Chi A....Hunt D.F. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain. (PubMed id 8197205)^{1, 2} Mikol V.... Walkinshaw M.D. (1994)
S-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin. (PubMed id 1530944)^{1, 2} Arber S.... Caroni P. (1992)
Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)^{1, 2} Rasmussen H.H....Vandekerckhove J. (1992)
An endoplasmic reticulum-specific cyclophilin. (PubMed id 1710767)^{1, 2} Hasel K.W.... Sutcliffe J.G. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5479	HGNC: 9255	AceView: PPIB	Ensembl:ENSG00000166794	euGenes: HUgn5479
ECgene: PPIB	H-InvDB: PPIB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PPIB	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/ppib/
Osteogenesis imperfecta variant database	http://oi.gene.le.ac.uk/home.php?select_db=PPIB

Intellectual Property for PPIB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PPIB gene:
Search GeneIP for patents involving PPIB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

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peptidylprolyl isomerase B (cyclophilin B)

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PPIB Gene

peptidylprolyl isomerase B (cyclophilin B)

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