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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPIB Gene

protein-coding   GIFtS: 72
GCID: GC15M064448

peptidylprolyl isomerase B (cyclophilin B)
 Explore 19 diseases affiliated with
PPIB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PPIB    

Aliases
for PPIB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Peptidylprolyl Isomerase B (Cyclophilin B)1 2     SCYLP2 3
CYPB1 2 3 5     PPIase B2 3
OI91 2 5     EC 5.2.1.83 8
Rotamase B2 3     Cyclophilin-Like Protein2
CYP-S12 3     Peptidyl-Prolyl Cis-Trans Isomerase B2
S-Cyclophilin1     Cyclophilin B3

External Ids:    HGNC: 92551   Entrez Gene: 54792   Ensembl: ENSG000001667947   OMIM: 1238415   UniProtKB: P232843   

Export aliases for PPIB gene to outside databases

Previous GC identifers: GC15M060234 GC15M057607 GC15M062026 GC15M062163 GC15M062235 GC15M041272


Summaries
for PPIB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PPIB:
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic
reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to
cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have
been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. (provided by RefSeq, Oct
2009)

UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides

Gene Wiki entry for PPIB


Genomic Views
for PPIB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPIB gene promoter:
         Bach1   AP-1   Tal-1   E47   AREB6   FAC1   Pax-3   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPIB promoter sequence
   Search SABiosciences Chromatin IP Primers for PPIB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21-q22   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q21-q22

PPIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIB gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M064448:  view genomic region     (about GC identifiers)

Start:
 64,448,011 bp from pter      End:
 64,455,404 bp from pter
Size:
 7,394 bases      Orientation:
 minus strand

Proteins
for PPIB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase B precursor  
Size: 216 amino acids; 23743 Da
Subunit: Interacts with DYM
Subcellular location: Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome
fractions from stage I to stage IV
Caution: It is uncertain whether Met-1 or Met-9 is the initiator
Sequence caution: Sequence=AAA52150.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for PPIB:
1CYN (3D)        3ICH (3D)        3ICI (3D)    
Secondary accessions: A8K534 Q6IBH5 Q9BVK5

Explore the universe of human proteins at neXtProt for PPIB: NX_P23284

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P23284

    • 4/10 DME Specific Peptides for PPIB (P23284) (see all 10)
     GGKSIYG  FMIQGGD  GKTVPKT  TNGSQFF 

    PPIB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000933.1  
    ENSEMBL proteins: 
     ENSP00000300026  
    Reactome Protein details: P23284
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: PPIB
    OriGene Protein Over-expression Lysate: PPIB
    OriGene Custom Protein Services for PPIB 
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    Novus Biologicals PPIB Proteins
    Novus Biologicals PPIB Lysate
    Sino Biological Recombinant Protein for PPIB
    ProSpec Recombinant Protein for PPIB
    Uscn Proteins for PPIB

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS2000394
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0042470melanosome IEA--


    PPIB for ontologies           About GeneDecksing



    PPIB Antibody Products: 
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    Uscn Antibodies for PPIB
    ThermoFisher Antibody for PPIB

    Assay Products for PPIB: 
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    Uscn ELISAs and CLIAs for PPIB

    Protein Domains /
    Families
    for PPIB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PPIB for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002130 Cyclophilin-like_PPIase_dom
     IPR024936 Cyclophilin-type_PPIase
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry P23284

    ProtoNet protein and cluster: P23284

    1 Blocks protein family: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284
    Similarity: Belongs to the cyclophilin-type PPIase family. PPIase B subfamily
    Similarity: Contains 1 PPIase cyclophilin-type domain


    Function
    for PPIB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Cyclosporin A (CsA) inhibits CYPB

         Genatlas biochemistry entry for PPIB:
    peptidyl-propyl isomerase B

    Enzyme Number (IUBMB): EC 5.2.1.81 2

    miRNA
    Products:            		miRTarBase miRNAs that target PPIB:
    hsa-mir-1 (MIRT001347)

    OriGene 3'-UTR Clone: PPIB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPIB
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIB:
    hsa-miR-206 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-613 hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmid: PPIB 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPIB (see all 7)
    OriGene shRNA RFP: PPIB
    OriGene siRNA: PPIB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PPIB

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIB (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIB
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PPIB (NM_000942)
    Sino Biological Human cDNA Clone for PPIB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIB 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PPIB
    Search LifeMap BioReagents cell lines for PPIB

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PPIB

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity NAS2000394
    GO:0005515protein binding IPI15095401
    GO:0042277peptide binding IEA--
    GO:0051082unfolded protein binding TAS2000394


    PPIB for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for PPIB:
     Increased G1 DNA content  Increased HPV18 LCR reporter a  Wnt reporter downregulated 

    Animal Models:
         Mouse knock-out Ppibtm1.1Rjb for PPIB
         5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ppib):
     growth/size  integument  mortality/aging  no phenotypic analysis  skeleton 

    PPIB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PPIB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Collagen formation
    		Collagen formation1.00
    		Extracellular matrix organization0.54
    		Collagen biosynthesis and modifying enzymes0.74
    2BAFF in B-Cell Signaling
    		Apoptosis and survival_APRIL and BAFF signaling0.39
    		Apoptosis and survival APRIL and BAFF signaling0.39
    3Syndecan-1-mediated signaling events
    		Syndecan-1-mediated signaling events1.00
    4Development_Prolactin receptor signaling
    		Prolactin Signaling Pathway0.39

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PPIB
        Apoptosis and survival APRIL and BAFF signaling


    1 GeneGo (Thomson Reuters) Pathway for PPIB
        Apoptosis and survival APRIL and BAFF signaling

    2 BioSystems Pathways for PPIB 
        Prolactin Signaling Pathway
    Syndecan-1-mediated signaling events

    3        Reactome Pathways for PPIB
        Extracellular matrix organization
    Collagen biosynthesis and modifying enzymes
    Collagen formation



    PPIB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPIB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/55 Interacting proteins for PPIB (P232842, 3 ENSP000003000264) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF1Q130772, 3MINT-49520 I2D: score=2 
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2861854 I2D: score=3 STRING: ENSP00000357292
    DNM2P505703, ENSP000003527214I2D: score=3 STRING: ENSP00000352721
    APOBP041143, ENSP000002332424I2D: score=2 STRING: ENSP00000233242
    USP21Q9UK803, ENSP000002898654I2D: score=2 STRING: ENSP00000289865
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization NAS2000394
    GO:0006457protein folding IEA--
    GO:0030198extracellular matrix organization TAS--


    PPIB for ontologies           About GeneDecksing



    Drugs & Compounds
    for PPIB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPIB for compounds           About GeneDecksing

    EMD Millipore small molecules for PPIB:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPIB

    1 HMDB Compound for PPIB    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Proline(-)-(S)-Proline (see all 16)147-85-3--

    2 DrugBank Compounds for PPIB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Proline(-)-2-Pyrrolidinecarboxylic acid (see all 6)147-85-3targetbinder17139284 11752352 17016423
    1,4-Dithiothreitol-- --target--10592235

    5 Novoseek chemical compound relationships for PPIB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclosporin a 69.9 42 9378502 (4), 10386979 (4), 8713086 (3), 11955071 (2) (see all 19)
    heparan sulfate 56.2 21 19940140 (4), 17588944 (4), 15109301 (4)
    proline 38.6 5 19781681 (2), 17630507 (1)
    anti-fungal 24.4 3 15245883 (1), 11848297 (1), 11732686 (1)
    heparin 22.8 6 15109301 (4), 19940140 (1)

    Search CenterWatch for drugs/clinical trials and news about PPIB 

    Transcripts
    for PPIB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PPIB gene: 
    NM_000942.4  

    Unigene Cluster for PPIB:

    Peptidylprolyl isomerase B (cyclophilin B)
    Hs.434937  [show with all ESTs]
    Unigene Representative Sequence: BQ049986
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300026(uc002and.3) ENST00000558492 ENST00000561048(uc010bgx.1)


    miRNA
    Products:             		 OriGene 3'-UTR Clone: PPIB
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPIB
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate PPIB:
    hsa-miR-206 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-613 hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmid: PPIB 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPIB (see all 7)
    OriGene shRNA RFP: PPIB
    OriGene siRNA: PPIB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIB
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIB (see first 1)
    NM_000942 (human cat#: RC203180)  NM_011149 (mouse cat#: MR220872)  NM_022536 (rat cat#: RR213873)  
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIB
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIB

    Additional cDNA sequence: 

    AK291149.1 AK311074.1 BC001125.2 BC008848.2 BC020800.1 BC032138.2 CR456829.1 M60457.1 
    M60857.1 M63573.1 

    24/30 DOTS entries (see all 30):

    DT.95344633  DT.100845917  DT.119195  DT.95352178  DT.100845915  DT.100845910  DT.95352206  DT.101985571 
    DT.97784070  DT.100845912  DT.100845914  DT.100845919  DT.95237355  DT.100845913  DT.121023162  DT.121023414 
    DT.92068163  DT.92457228  DT.95352171  DT.121023234  DT.121023413  DT.121023420  DT.92457220  DT.95147920 

    24/953 AceView cDNA sequences (see all 953):

    CF552399 AJ712593 BP338061 BM831044 BM741113 BM785350 BM802364 BM756176 
    BM969712 BM781952 BM830826 BM848965 BI768795 BX335040 BU507664 BQ637087 
    BM503216 BM848839 BM747383 CA843061 BI823156 BU623904 BM825548 BQ439218 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PPIB    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
    SP1:                                -                     
    SP2:                    -           -                     
    SP3:                                                      


    ECgene alternative splicing isoforms for PPIB

    Expression
    for PPIB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPIB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACTCACTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PPIB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneEndochondral Facial BonesBone
    BoneRostral Endochondral Facial BonesBone
    BoneRostral Skull Membranous BonesBone
    BoneThoracic RibBone
    CartilageCaudal SynchondrosesCartilage
    CartilageChondrocraniumCartilage
    CartilageRostral ChondrocraniumCartilage
    CartilageRostral SynchondrosesCartilage
    CartilageSynchondrosesCartilage
    Head MesenchymeHead MesenchymeHead Mesenchyme
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PPIB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPIB

    SOURCE GeneReport for Unigene cluster: Hs.434937
        SABiosciences Custom PCR Arrays for PPIB
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIB
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PPIB

    Orthologs
    for PPIB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPIB gene from 9/36 species (see all 36)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PPIB1 peptidylprolyl isomerase B (cyclophilin B) 80.84(n)
    86.47(a)    		   396447  NM_205461.1  NP_990792.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PPIB6
    		 --
    		 83(a)
    		 1 ↔ 1
    		 GL343490.1(417575-422070)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ppib-prov2 peptidylprolyl isomerase B 76.63(n)    BC054168.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa97f082 Danio rerio cDNA clone MGC73214 IMAGE4790964, complete more 79.36(n)    BC059560.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG28521 , 3 peptidyl-prolyl cis-trans isomerase3
    CG28521    		 73(a)
    (best of 2)3
    68.17(n)1
    67.5(a)1    		   58F33
    375911  NM_137851.31  NP_611695.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea cyp-53
    cyn-51    		 cyclophillin3
    Protein CYN-51    		 71(a)
    (best of 4)3
    63.35(n)1
    67.66(a)1    		   I(15048595-15049564)3
    1733741  NM_061223.41  NP_493624.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CPR5(YDR304C)4
    CPR51    		 Peptidyl-prolyl cis-trans isomerase (cyclophilin) of more4
    Cpr5p1    		 55.85(n)1
    56.38(a)1    		   4(1072557-1071880)4
    8518981, 4  NP_010590.31  NP_010590.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G559201 peptidyl-prolyl cis-trans isomerase 61.62(n)
    65.45(a)    		   824758  NM_115450.3  NP_567029.1 
    rice
    (Oryza sativa)    		 Liliopsida AK104772.12   -- 75.26(n)    AK104772.1 


    ENSEMBL Gene Tree for PPIB (if available)
    TreeFam Gene Tree for PPIB (if available) 

    Paralogs
    for PPIB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPIB gene
    CWC272  PPIL42  PPWD12  PPIL32  PPIH2  PPIC2  PPIL12  PPIL22  
    18/22 SIMAP similar genes for PPIB using alignment to 1 protein entry:     PPIB_HUMAN(see all similar genes):
    PPIC    PPIA    PPIE    PPIF    PPIH    LOC402252
    RANBP2    PPIL1    PPID    PPIAL4A    PPIAL4B    PPIAL4C
    PPIAL4G    PPIG    NKTR    PPWD1    PPIL3    PPIL6

    PPIB for paralogs           About GeneDecksing



    Genomic Variants
    for PPIB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/203 NCBI SNPs in PPIB are shown (see all 203)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1214345591,2
    		Cpathogenic64449001(-) GCTCCC/TAGTTC 3 Q * stg1 ut310--------
    rs1378538641,2
    		Cpathogenic64455160(-) CAACAG/TGAAGG 2 R M mis10--------
    rs287201931,2
    		Cuntested64448960(-) GATGGC/GAAGCA 3 G syn1 ut315Minor allele frequency- G:0.00NS 188
    rs23072471,2
    		C,F,H,untested64452322(-) TTCACC/TAGGGG 2 T syn1 ese312Minor allele frequency- T:0.01NA NS EU 6725
    rs115585951,2
    		C,F,Huntested64454311(-) GCCGGG/TTGATC 2 V L mis1 ese39Minor allele frequency- T:0.00NS EA NA 762
    rs49041,2
    		C,F,H,untested64455123(-) GGGTCC/AGTCTT 2 /S syn1 ese318Minor allele frequency- A:0.02MN EA NS WA NA EU 7035
    rs1818487441,2
    		--64447594(+) GTCAGC/GTGGGT 2 -- ds5001 ut310--------
    rs38967871,2
    		H--64447742(+) ATTTAG/AAGGTA 2 -- ds5001 ut315Minor allele frequency- A:0.00MN NS EA 562
    rs1864578931,2
    		--64447773(+) ACATCA/CCTTAA 2 -- ut31 ds50010--------
    rs38589111,2
    		C,H--64447783(+) ACATAG/AACTGG 2 -- ds5001 ut315Minor allele frequency- A:0.00MN NS EA 602

    HapMap Linkage Disequilibrium report for PPIB (64448011 - 64455404 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PPIB: --
    Human Gene Mutation Database (HGMD): PPIB

    Locus Specific Mutation Databases (LSDB): PPIB

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPIB
    DNA2.0 Custom Variant and Variant Library Synthesis for PPIB

    Disorders / Diseases
    for PPIB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PPIB for disorders           About GeneDecksing

    OMIM gene information: 123841   
    OMIM disorders: 259440  
    UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284
  • Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9) [MIM:259440]. OI9 is a connective tissue
    • disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb
    dwarfism and blue sclerae are observed in some but not all patients

    19 diseases for PPIB:    About MalaCards
    osteogenesis imperfecta    osteogenesis imperfecta type 9    dentinogenesis imperfecta    connective tissue disease
    syphilis    dwarfism    nephrotic syndrome    multiple myeloma
    hepatitis c    encephalitis    myeloma    hepatocellular carcinoma
    breast cancer    ataxia    hepatitis    immunodeficiency
    carcinoma    pancreatitis    malaria

    1 disease from the University of Copenhagen DISEASES database for PPIB:
    Osteogenesis imperfecta
    Human Genome Epidemiology (HuGE) Navigator: PPIB (1 document)

    Export disorders for PPIB gene to outside databases

    Publications
    for PPIB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPIB gene, integrated from 9 sources (see all 110):
    (articles sorted by number of sources associating them with PPIB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cyclophilin B: a second cyclophilin gene encodes a peptidyl- prolyl isomerase with a signal sequence. (PubMed id 2000394)1, 2, 3, 9 Price E.R....Walsh C.T. (1991)
    2. Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding. (PubMed id 20089953)1, 2, 3, 9 Barnes A.M....Marini J.C. (2010)
    3. PPIB mutations cause severe osteogenesis imperfecta. (PubMed id 19781681)1, 2, 9 van Dijk F.S.... Pals G. (2009)
    4. A novel secreted cyclophilin-like protein (SCYLP). (PubMed id 2040592)1, 2, 9 Spik G.... Movva N.R. (1991)
    5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain. (PubMed id 8197205)1, 2 Mikol V.... Walkinshaw M.D. (1994)
    8. S-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin. (PubMed id 1530944)1, 2 Arber S.... Caroni P. (1992)
    9. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (1992)
    10. An endoplasmic reticulum-specific cyclophilin. (PubMed id 1710767)1, 2 Hasel K.W.... Sutcliffe J.G. (1991)

    External Searches for PPIB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PPIB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5479 HGNC: 9255 AceView: PPIB Ensembl:ENSG00000166794 euGenes: HUgn5479
    ECgene: PPIB H-InvDB: PPIB

    Other Databases showing PPIB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PPIB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPIB Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ppib/
    Osteogenesis imperfecta variant databasehttp://oi.gene.le.ac.uk/home.php?select_db=PPIB

    Intellectual Property
    for PPIB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PPIB gene:
    Search GeneIP for patents involving PPIB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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