Aliases for PPIB Gene
External Ids for PPIB Gene
Previous GeneCards Identifiers for PPIB Gene
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]
GeneCards Summary for PPIB Gene
PPIB (Peptidylprolyl Isomerase B) is a Protein Coding gene. Diseases associated with PPIB include Osteogenesis Imperfecta, Type Ix and Osteogenesis Imperfecta, Type Ii. Among its related pathways are Collagen chain trimerization and RANK Signaling in Osteoclasts. Gene Ontology (GO) annotations related to this gene include unfolded protein binding. An important paralog of this gene is PPIC.
UniProtKB/Swiss-Prot for PPIB Gene
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.