Aliases for PPIB Gene
External Ids for PPIB Gene
Previous GeneCards Identifiers for PPIB Gene
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]
GeneCards Summary for PPIB Gene
PPIB (Peptidylprolyl Isomerase B (Cyclophilin B)) is a Protein Coding gene. Diseases associated with PPIB include ppib-related osteogenesis imperfecta and osteogenesis imperfecta, type ix. Among its related pathways are Degradation of the extracellular matrix and RANK Signaling in Osteoclasts. GO annotations related to this gene include poly(A) RNA binding and unfolded protein binding. An important paralog of this gene is PPIL1.
UniProtKB/Swiss-Prot for PPIB Gene
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides