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PPIB Gene

protein-coding   GIFtS: 75
GCID: GC15M064448

Peptidylprolyl Isomerase B (Cyclophilin B)

  See PPIB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peptidylprolyl Isomerase B (Cyclophilin B)1 2     EC 5.2.1.83 8
CYPB2 3 5     OI92 5
Rotamase B2 3     HEL-S-392
CYP-S12 3     Cyclophilin-Like Protein2
S-cyclophilin2 3     Epididymis Secretory Protein Li 392
SCYLP2 3     Peptidyl-Prolyl Cis-Trans Isomerase B2
PPIase B2 3     Cyclophilin B3

External Ids:    HGNC: 92551   Entrez Gene: 54792   Ensembl: ENSG000001667947   OMIM: 1238415   UniProtKB: P232843   

Export aliases for PPIB gene to outside databases

Previous GC identifers: GC15M060234 GC15M057607 GC15M062026 GC15M062163 GC15M062235 GC15M041272


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPIB Gene:
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic
reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind
to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants
have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. (provided by
RefSeq, Oct 2009)

GeneCards Summary for PPIB Gene:
PPIB (peptidylprolyl isomerase B (cyclophilin B)) is a protein-coding gene. Diseases associated with PPIB include ppib-related osteogenesis imperfecta, and osteogenesis imperfecta type 9. GO annotations related to this gene include unfolded protein binding and peptide binding. An important paralog of this gene is PPIH.

UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides

Gene Wiki entry for PPIB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPIB gene promoter:
         Bach1   AP-1   Tal-1   E47   AREB6   FAC1   Pax-3   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPIB promoter sequence
   Search Chromatin IP Primers for PPIB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPIB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21-q22   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q21-q22

PPIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIB gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M064448:  view genomic region     (about GC identifiers)

Start:
64,448,011 bp from pter      End:
64,455,404 bp from pter
Size:
7,394 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase B precursor  
Size: 216 amino acids; 23743 Da
Subunit: Interacts with DYM
Caution: It is uncertain whether Met-1 or Met-9 is the initiator
Sequence caution: Sequence=AAA52150.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for PPIB:
1CYN (3D)        3ICH (3D)        3ICI (3D)    
Secondary accessions: A8K534 Q6IBH5 Q9BVK5

Explore the universe of human proteins at neXtProt for PPIB: NX_P23284

Explore proteomics data for PPIB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys67, Lys98, Lys131, Lys158, Lys165, Lys209
  • Glycosylation2 at Asn148
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPIB (P23284) (see all 10)
     GGKSIYG  FMIQGGD  GKTVPKT  TNGSQFF 


    See PPIB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000933.1  
    ENSEMBL proteins: 
     ENSP00000300026  
    Reactome Protein details: P23284

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    Search eBioscience for ELISAs for PPIB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002130 Cyclophilin-type_PPIase_dom
     IPR024936 Cyclophilin-type_PPIase
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry P23284

    ProtoNet protein and cluster: P23284

    1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284
    Similarity: Belongs to the cyclophilin-type PPIase family. PPIase B subfamily
    Similarity: Contains 1 PPIase cyclophilin-type domain


    Find genes that share domains with PPIB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPIB_HUMAN, P23284
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Cyclosporin A (CsA) inhibits CYPB

         Genatlas biochemistry entry for PPIB:
    peptidyl-propyl isomerase B

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity NAS2000394
    GO:0005515protein binding IPI15095401
    GO:0005518contributes to collagen binding ISS--
    GO:0032403protein complex binding ISS--
    GO:0042277peptide binding IEA--
         
    Find genes that share ontologies with PPIB           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PPIB:
     Increased G1 DNA content  Increased HPV18 LCR reporter a  Wnt reporter downregulated 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ppib):
     growth/size/body  integument  mortality/aging  no phenotypic analysis  skeleton 

    Find genes that share phenotypes with PPIB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ppibtm1.1Rjb for PPIB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPIB
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPIB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPIB

    miRNA
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    miRTarBase miRNAs that target PPIB:
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    5 qRT-PCR Assays for microRNAs that regulate PPIB:
    hsa-miR-206 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-613 hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmidPPIB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPIB

    Gene Editing
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    Sino Biological Human cDNA Clone for PPIB
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    Addgene plasmids for PPIB 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPIB_HUMAN, P23284: Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome
    fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular3
    cytosol1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0032991macromolecular complex ISS--
    GO:0042470melanosome IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with PPIB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPIB About    
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.75
    Collagen formation0.75
    2RANK Signaling in Osteoclasts
    Apoptosis and survival APRIL and BAFF signaling0.39
    3Prolactin Signaling Pathway
    Prolactin Signaling Pathway0.39
    4Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    5Syndecan-1-mediated signaling events
    Syndecan-1-mediated signaling events


    Find genes that share SuperPaths with PPIB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for PPIB
        Apoptosis and survival APRIL and BAFF signaling

    2 BioSystems Pathways for PPIB
        Prolactin Signaling Pathway
    Syndecan-1-mediated signaling events


    1 Reactome Pathway for PPIB
        Collagen biosynthesis and modifying enzymes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPIB
    Interactions:

        GeneGlobe Interaction Network for PPIB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPIB (P232841, 2, 3 ENSP000003000264) via UniProtKB, MINT, STRING, and/or I2D (see all 151)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF1Q130772, 3MINT-49520 I2D: score=2 
    ENSG00000206353Q154773I2D: score=1 
    ENSG00000223493Q154773I2D: score=1 
    ENSG00000225737Q154773I2D: score=1 
    ENSG00000228896Q154773I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization ISS--
    GO:0006457protein folding ----
    GO:0030198extracellular matrix organization TAS--
    GO:0040018positive regulation of multicellular organism growth IMP--
    GO:0050821protein stabilization IMP--

    Find genes that share ontologies with PPIB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPIB

    1 HMDB Compound for PPIB    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Proline(-)-(S)-Proline (see all 16)147-85-3--

    2 DrugBank Compounds for PPIB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Proline(-)-2-Pyrrolidinecarboxylic acid (see all 6)147-85-3targetbinder17139284 11752352 17016423
    1,4-Dithiothreitol-- --target--10592235

    5 Novoseek inferred chemical compound relationships for PPIB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclosporin a 69.9 42 9378502 (4), 10386979 (4), 8713086 (3), 11955071 (2) (see all 19)
    heparan sulfate 56.2 21 19940140 (4), 17588944 (4), 15109301 (4)
    proline 38.6 5 19781681 (2), 17630507 (1)
    anti-fungal 24.4 3 15245883 (1), 11848297 (1), 11732686 (1)
    heparin 22.8 6 15109301 (4), 19940140 (1)



    Find genes that share compounds with PPIB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPIB gene: 
    NM_000942.4  

    Unigene Cluster for PPIB:

    Peptidylprolyl isomerase B (cyclophilin B)
    Hs.434937  [show with all ESTs]
    Unigene Representative Sequence: BQ049986
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300026(uc002and.3) ENST00000558492 ENST00000561048(uc010bgx.1)

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    hsa-miR-206 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-613 hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmidPPIB 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK291149.1 AK311074.1 BC001125.2 BC008848.2 BC020800.1 BC032138.2 CR456829.1 M60457.1 
    M60857.1 M63573.1 

    Selected DOTS entries (see all 27):

    DT.95344633  DT.119195  DT.100845917  DT.95352178  DT.100845915  DT.100845910  DT.95352206  DT.97784070 
    DT.100845912  DT.100845913  DT.100845919  DT.121023162  DT.121023414  DT.92068163  DT.92457228  DT.95237355 
    DT.95352171  DT.100845914  DT.121023234  DT.121023413  DT.121023420  DT.92457220  DT.95147920  DT.95352090 

    953 AceView cDNA sequences (see top 24):

    AW069876 BM461482 BC001125 BM826368 BU849690 BU077971 CA865787 BI768795 
    BG291432 BQ020844 CN484237 BM831044 BM825346 H28029 BQ683403 CF527923 
    BM825696 BM772843 BM830826 BM272656 BE907521 BM832180 CB133821 BM831000 
    BM756176 BX377936 BG119580 BM818959 BQ681132 BM831116 BQ924469 BM545004 
    BP338061 CD724155 BI823156 BQ221928 CA448042 BU623904 AJ712593 H64623 
    BQ901140 BQ433727 BU184930 BM781952 BM825548 BQ637087 BE256255 AA319269 
    BM790287 CR616922 BX374937 BM830815 AA371710 BM741113 D28465 BM802364 
    AU076585 BM738655 BM829960 BE383131 BX421459 BM823599 BU839052 BQ771566 
    BM826746 BX335040 BM818902 CB114010 BU181167 CR617864 BC032138 NM_000942 
    BX365792 BQ639266 BG118764 AI858237 BM747383 CB139215 BQ668345 BM848965 
    BQ690831 BM836056 BE894788 BU179578 BQ878185 BM473022 BU191444 BU943933 
    CF127720 BE385011 BM757927 BM771984 BU507664 BM819645 BM848908 BQ214119 
    BM830995 CA413148 CR591528 CA843061 BQ670094 BI833663 BM830965 BM823598 
    BQ678793 BI518759 CA489107 BM543386 BQ439218 BU187796 BM969712 CF552399 
    BU676609 BM770117 BM830946 CA843122 BU078219 BM461739 CR595940 BM825654 
    D79125 BQ685210 BM785350 BM761921 BM830823 BM848839 BM823645 BP375499 
    BM856546 CR599100 BM829980 BM851207 BM468509 BF968021 BM503216 BQ223180 
    AW473332 BQ646775 BM851282 BI917046 CA445299 BM771388 H38201 BG481831 
    BQ083380 BG290784 BQ276360 BE789501 BI857296 BP354038 BQ223864 BM717788 
    CD050701 BE904789 BE255596 BE314030 AA300553 H70129 BM006218 CD686825 
    CA865535 BG249903 AA377557 BQ681722 BM856579 BM820054 AI874282 BQ083591 
    BG765546 BI868399 AA041378 BF315869 M60457 CA772674 AU154376 BQ673173 
    BM755843 BU633828 BU622788 AA345407 BM739767 BE260225 BQ653613 BM850013 
    BE902660 BM848984 BG564418 BE728460 BE786312 BE274864 BX425717 BU659072 
    BF182790 BF968636 M63573 BG763893 BG119773 BI197316 BE075903 BG110675 
    BG169125 H96665 BI199509 BQ644076 BU839248 BI196530 BE905033 BF206217 
    BI193214 BM759975 T59969 BF339798 BP338318 BQ430181 N72032 BM142568 
    BE796018 BC008848 BU191134 BG028089 BM831076 AA505769 CD388413 BG026799 
    BQ931949 BP351947 AA330749 N31525 BE880221 CD385020 BI089125 BG470050 
    BG420509 BG115754 AA405732 BM503374 BG179337 BQ329053 BM769844 BQ315859 
    M60857 H64624 AA341690 AV721524 BG288717 BM771483 BE878321 BG539632 
    BM745526 CA309810 BG748922 BF310299 CB106378 BG113551 BM272895 BU624925 
    CB051872 BX336068 BI856449 CB990563 BG482579 N95711 BU157311 BQ315874 
    BE263605 BM825566 BG327625 BM819053 CR456829 BP371882 BP378424 BF793179 
    BG282122 BE909568 BF038254 BE293308 BM475006 BU929305 BM835251 BI256493 
    BM738623 BU940003 AA311048 BE906113 BU615466 AL521566 CB128818 BM926444 
    R70193 BG823250 BE782221 BG567814 BC020800 AA340927 AA300659 CD049229 
    BG110483 BX482168 CF130025 CF527728 H30503 BU959591 CN481652 BM850020 
    CA775273 BE386706 BP381408 BE730825 BF344914 BF343720 BP343660 BM835580 
    BQ437033 AW406435 BQ653229 BG770302 BU784431 BU595602 BF342405 BE899138 
    BX333970 BQ679216 CB116900 BG437068 BM021931 CD609869 BE728134 BF309091 
    BM015421 BP431981 BI093128 BM887628 BE868117 BE264281 BF971354 BU598742 
    BM768568 BI899381 AU132947 BG387361 CB986403 BX344244 BU788100 BG165408 
    BG110524 BM041233 CD386312 CD389773 CD386080 BG475584 BQ772065 BE873914 
    BE893911 CN484467 BF035338 BQ574222 BG618047 N78663 BG105366 BU188767 
    BM051089 BG548669 BE256823 CB116464 BG255203 BM756280 BG168389 BF964982 
    BQ648298 BI196945 CD050826 AW157859 BE788244 BQ880301 BM041158 BQ878872 
    CB962043 BM262991 BQ439492 CD690911 BG481674 BM823492 BG253457 CD050010 
    BM739874 AI799707 CN484797 BU077713 BX401962 CD673082 AA335419 BE548415 
    BG117367 BM851084 BU196914 CF126200 BQ706762 AI151195 AW950229 AL552931 
    BF793392 BF313550 BQ351202 BQ005529 BG104995 AI685522 W46569 BF089971 
    BQ226846 BE547745 AW474648 AV750982 AI658746 BI051205 CD696739 CA414623 
    BF315104 CD609873 BQ315861 BU630895 BF680267 BG420584 CD246311 BF529521 
    N71262 BQ367685 BM851173 BU532171 BM823548 BF691775 BG874438 BE877408 
    CD050905 AA347215 BM685680 BG928837 H39510 AA676347 BI001682 BI198310 
    BG981980 BF679612 AI752964 BF340314 BQ379404 BE898712 U95646 BG035773 
    BG115817 H70141 BU682447 AA683180 AV748748 BQ347571 BU580049 AI669237 
    BG169445 CB857767 AA932533 BQ299714 AV724041 H25499 AI911809 CA419223 
    BF183186 BE258630 BQ299713 BM476206 BG422084 BE563888 BF477830 W44943 
    AA339534 N25666 AI873651 BG104944 BM918271 BE735901 CA775540 BP872633 
    AI244252 BM755740 H37980 AI636813 BF668331 BE732386 AA344939 BF304364 
    BE251888 AW079732 BQ372980 AW072107 BF665289 BP431706 BQ330165 BG945633 
    BQ374809 BG475458 AA464356 BG028967 AL708511 CD609868 BG996152 CB215100 
    AA460292 BG545610 BI763882 BE905838 BP379599 N42464 BG997079 BM973687 
    BQ299727 BM047490 T29872 BM856685 H70130 BE621592 BE875197 CA418454 
    BM565074 BM468510 BX397928 BQ299724 N21510 BQ374372 BQ354470 BQ315855 
    AI672900 BF315441 BM825509 AI658831 BE313764 W39593 BF982353 BQ299738 
    CD684224 CB164678 AA617719 CD693994 AV695742 AA152179 BU590106 BG993780 
    AV686370 CA437566 BU625179 BP373413 CD693579 CA306896 AI288096 CD706592 
    AA923066 BQ367684 BG328002 AW860560 AA126478 AV748753 BQ373065 BQ362378 
    BU565775 BG259878 BM662924 BG751727 BQ299715 BQ299723 BG953633 BF576741 
    BM706502 T59878 BQ299711 R73752 BP371908 AI927851 AI189989 BM691172 
    BG945650 BQ292310 BG117924 N71712 BQ676206 AI200522 BQ315862 H25156 
    CD689917 BG945656 BU940771 BF697543 BF669408 BQ271199 BG945669 BQ315851 
    BM770456 BI051185 BQ299725 BQ299749 H96541 AV691528 AJ707255 BP340234 
    C02618 AI140261 AA088511 BG776550 AA195473 H16158 BI051204 CD700319 
    H15847 AA375124 W25031 BI001523 W59941 BI042874 BG996215 BG945663 
    BQ350975 BG945660 AA576737 BI004999 H25500 BG008936 CD689528 BG945636 
    BG945666 BQ329253 BG945668 AA354385 BI051182 BU951595 BQ299737 CA418669 
    BQ299752 AI027038 BF174843 BG164948 AW243746 BM818934 R83778 N20397 
    BG945657 BQ378568 R83344 N22863 BQ299726 BQ299736 BP379828 BQ352860 
    BF793965 BI024043 BF673819 AA928475 BI051191 BI042871 BQ299740 BM748936 
    BI051178 BI194594 N79560 BG998132 BE960835 BG945665 BF095629 BQ379576 
    BG983775 BX438964 BG945644 R33096 AV708851 BI524022 H22238 BQ299745 
    N25489 BG945647 BG945677 BG945641 BQ359808 BG945653 BG945632 AI190054 
    BQ299733 BQ299747 D53319 BI021785 BG945645 BF312219 CD707851 BQ271498 
    BU185244 BF700293 BF677004 AA976043 BQ299717 N75425 C18577 BG945652 
    AA304961 AI001215 AW276899 AA595399 BI051190 N80056 BE503528 AW977236 
    BF174092 BF668401 BI042673 BQ367200 AI984852 BG945638 AA632629 BG878498 
    BQ299712 BQ299751 AA291447 AA037187 BG981672 BG945673 BQ299734 W46988 
    AU099916 AA729917 BQ378720 AI524956 BG945658 N20095 AA557768 BG945635 
    BG952520 BE930937 BG285593 BQ439617 BG945670 BG008947 BG945671 BG878503 
    AA632627 AW801113 BI005697 BI021793 BG945639 BI051201 N99485 CD707551 
    BG952141 BQ299742 BG945651 AA868208 BI024174 BG945664 N90698 AA190547 
    BQ322766 BI005217 AI702373 BQ329250 AI569370 BF095728 BQ299744 AI264463 
    BQ051158 BM888279 BQ299735 CB051873 N39292 BQ299741 AW516719 BG945661 
    BG945676 BF353220 H67874 BQ299730 BQ359520 BG105457 BG945672 BQ359521 
    BI005238 BG945648 BE313988 BE748286 BG992681 BQ299719 BQ373068 AA935411 
    AI123275 BG314797 BG945659 BI042868 BQ299731 BQ299728 BG945646 BQ292182 
    BF840773 BI001152 BQ187260 BG483645 BI004638 BF734141 BI051192 BQ360990 
    BU536969 BG959437 BG283309 BI910344 BF971263 AI369903 AI819243 BG945662 
    BQ299746 BE772839 AI749940 AI933241 AI869898 BI042678 BQ379442 BF525883 
    BQ299729 AA337055 AV704674 BG566296 BG950498 AI918484 BQ356035 BG981509 
    BF174149 AV701703 AW272962 BF830215 BG996077 AA844255 AI698515 AA933701 
    H82596 BI005225 BI042677 BQ299718 BG981014 BG959430 BG959791 AI860540 
    BE905919 BQ378428 BM310634 BQ299721 BG008932 BE930948 AW389250 AA057792 
    BU194312 AI075108 AV752868 W24865 BM850008 BQ299710 BF095688 F00911 
    BQ378355 BE408617 BU953435 BI021791 BG981976 BI002634 BG981973 BG170377 
    BE905993 BI051199 BQ051668 BQ319723 BG959823 BI018560 BG959804 AI003622 
    BG475774 BF909589 BG983815 AW518666 BQ349888 CD705659 BG981472 BE838119 
    BG952137 BF927777 BG953638 BF752195 BI003841 BQ299720 BQ304511 BI004636 
    BG328033 BF248227 BF678818 AI865178 W07016 AI186758 AA216170 BI051193 
    BF678473 BF908634 BI051180 BG996222 BF961272 BQ299739 BG959433 BG327996 
    W20111 BQ367683 R80575 BQ379481 BG996228 BQ377515 BE786788 BQ060022 
    BG981083 BG981089 BU602998 BG981488 BG981038 BF858997 BG981071 BG981073 
    BG981092 BG980769 BG983836 R82525 BG980717 AV703776 BI051203 BG981653 
    BG980531 BG983813 BQ326431 BG983781 BI021780 BF313324 BG983833 BG980741 
    BG983832 BI050585 BF086452 BG983729 AA903801 BI014386 BU956733 BG981031 
    BG983771 BI042676 BG981085 BE930896 BG993789 AI185253 BG996130 BQ379440 
    BF127542 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PPIB    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
    SP1:                                -                     
    SP2:                    -           -                     
    SP3:                                                      


    ECgene alternative splicing isoforms for PPIB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PPIB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTCACTTT
    PPIB Expression
    About this image


    PPIB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Endochondral Facial Bones
             HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    PPIB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPIB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434937
        Custom PCR Arrays for PPIB
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PPIB
    OriGene qSTAR qPCR primer pairs in human, mouse for PPIB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPIB
    QuantiTect SYBR Green Assays in human, mouse, rat PPIB
    QuantiFast Probe-based Assays in human, mouse, rat PPIB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPIB gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppib1 , 5 peptidylprolyl isomerase B1, 5 90.12(n)1
    93.98(a)1
      9 (35.69 cM)5
    190351  NM_011149.21  NP_035279.21 
     660601695 
    chicken
    (Gallus gallus)
    Aves PPIB1 peptidylprolyl isomerase B (cyclophilin B) 80.84(n)
    86.47(a)
      396447  NM_205461.1  NP_990792.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPIB6
    peptidylprolyl isomerase B (cyclophilin B)
    83(a)
    1 ↔ 1
    GL343490.1(417575-422070)
    African clawed frog
    (Xenopus laevis)
    Amphibia ppib-prov2 peptidylprolyl isomerase B 76.63(n)    BC054168.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa97f082 Danio rerio cDNA clone MGC73214 IMAGE4790964, complete more 79.36(n)    BC059560.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG28521 , 3 peptidyl-prolyl cis-trans isomerase3
    CG28521
    73(a)
    (best of 2)3
    68.17(n)1
    67.5(a)1
      58F33
    375911  NM_137851.31  NP_611695.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cyp-53
    cyn-51
    cyclophillin3
    cyn-51
    71(a)
    (best of 4)3
    63.35(n)1
    67.66(a)1
      I(15048595-15049564)3
    1733741  NM_061223.51  NP_493624.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CPR5(YDR304C)4
    CPR51
    Peptidyl-prolyl cis-trans isomerase (cyclophilin) of more4
    CPR51
    55.56(n)1
    56.08(a)1
      4(1072557-1071880)4
    8518981, 4  NP_010590.31  NP_010590.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYP20-21 CYP20-2 62.13(n)
    65.09(a)
      831151  NM_001203370.1  NP_001190299.1 
    rice
    (Oryza sativa)
    Liliopsida AK104772.12   -- 75.26(n)    AK104772.1 


    ENSEMBL Gene Tree for PPIB (if available)
    TreeFam Gene Tree for PPIB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for PPIB gene
    PPIH2  PPIC2  CWC272  PPWD12  PPIL42  PPIL22  PPIL32  PPIL12  
    Selected SIMAP similar genes for PPIB using alignment to 1 protein entry:     PPIB_HUMAN(see all similar genes):
    PPIC    PPIA    PPIE    PPIH    LOC402252    RANBP2
    PPIF    PPIL1    PPID    PPIAL4A    PPIAL4B    PPIAL4C
    PPIAL4D    PPIAL4G    PPIG    NKTR    PPWD1    PPIL3

    Find genes that share paralogs with PPIB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PPIB (see all 241)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0634364
    Osteogenesis imperfecta 9 (OI9)4--see VAR_0634362 M R mis40--------
    rs1214345591,2
    Cpathogenic144510211(-) GCTCCC/TAGTTC 2 Q * stg10--------
    rs1378538641,2
    Cpathogenic144516370(-) CAACAG/TGAAGG 2 R M mis10--------
    rs287201931,2
    Cuntested144510170(-) GATGGC/GAAGCA 2 G syn15Minor allele frequency- G:0.00NS 188
    rs23072471,2
    C,F,Huntested144513532(-) TTCACC/TAGGGG 2 T syn1 ese312Minor allele frequency- T:0.01NA NS EU 6725
    rs115585951,2,,4
    C,F,Huntested144515521(-) GCCGGG/TTGATC 2 V L mis1 ese39Minor allele frequency- T:0.00NS EA NA 762
    rs49041,2
    C,F,Huntested144516333(-) GGGTCC/AGTCTT 2 /S syn1 ese318Minor allele frequency- A:0.02MN EA NS WA NA EU 7035
    rs1818487441,2
    --44508805(+) GTCAGC/GTGGGT 1 -- ds50010--------
    rs38967871,2
    H--44508952(+) ATTTAG/AAGGTA 1 -- ds50015Minor allele frequency- A:0.00MN NS EA 562
    rs1864578931,2
    --44508983(+) ACATCA/CCTTAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for PPIB (64448011 - 64455404 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PPIB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833036CNV Loss17160897
    nsv827360CNV Loss20364138

    Human Gene Mutation Database (HGMD): PPIB
    Locus Specific Mutation Databases (LSDB): PPIB

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPIB
    DNA2.0 Custom Variant and Variant Library Synthesis for PPIB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 123841   
    OMIM disorders: 259440  
    UniProtKB/Swiss-Prot: PPIB_HUMAN, P23284
  • Osteogenesis imperfecta 9 (OI9) [MIM:259440]: A form of osteogenesis imperfecta, a connective tissue
    disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma.
    Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality.
    Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing
    loss, and blue sclerae. OI9 is a severe autosomal recessive form of the disorder. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 8 diseases for PPIB:    
    About MalaCards
    ppib-related osteogenesis imperfecta    osteogenesis imperfecta type 9    dyggve-melchior-clausen syndrome    japanese encephalitis
    osteogenesis imperfecta    osteogenesis imperfecta, type ii    osteogenesis imperfecta type 4    osteogenesis imperfecta type iii

    1 disease from the University of Copenhagen DISEASES database for PPIB:
    Osteogenesis imperfecta

    Find genes that share disorders with PPIB           About GenesLikeMe

    Genetic Association Database (GAD): PPIB
    Human Genome Epidemiology (HuGE) Navigator: PPIB (1 document)

    Export disorders for PPIB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for PPIB gene, integrated from 10 sources (see all 122):
    (articles sorted by number of sources associating them with PPIB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cyclophilin B: a second cyclophilin gene encodes a peptidyl- prolyl isomerase with a signal sequence. (PubMed id 2000394)1, 2, 3, 9 Price E.R....Walsh C.T. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding. (PubMed id 20089953)1, 2, 3, 9 Barnes A.M....Marini J.C. (N. Engl. J. Med. 2010)
    3. PPIB mutations cause severe osteogenesis imperfecta. (PubMed id 19781681)1, 2, 9 van Dijk F.S.... Pals G. (Am. J. Hum. Genet. 2009)
    4. A novel secreted cyclophilin-like protein (SCYLP). (PubMed id 2040592)1, 2, 9 Spik G.... Movva N.R. (J. Biol. Chem. 1991)
    5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain. (PubMed id 8197205)1, 2 Mikol V.... Walkinshaw M.D. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    8. S-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin. (PubMed id 1530944)1, 2 Arber S.... Caroni P. (J. Cell Biol. 1992)
    9. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (Electrophoresis 1992)
    10. An endoplasmic reticulum-specific cyclophilin. (PubMed id 1710767)1, 2 Hasel K.W.... Sutcliffe J.G. (Mol. Cell. Biol. 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5479 HGNC: 9255 AceView: PPIB Ensembl:ENSG00000166794 euGenes: HUgn5479
    ECgene: PPIB H-InvDB: PPIB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PPIB Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ppib/
    Osteogenesis imperfecta variant databasehttp://oi.gene.le.ac.uk/home.php?select_db=PPIB

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PPIB gene:
    Search GeneIP for patents involving PPIB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     EMD Millipore genomic analysis products

      
     Antibodies for PPIB (Cyclophilin B)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PPIB  
     OriGene qPCR primer pairs and template standards for PPIB   OriGene Protein Over-expression Lysate for PPIB  
     OriGene MassSpec something-or-other for PPIB   OriGene clones in human, mouse for PPIB  
     OriGene qSTAR qPCR primer pairs in human, mouse for PPIB   OriGene Purified Protein for PPIB  
     OriGene ORF clones in mouse, rat for PPIB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PPIB   OriGene Custom Protein Services for PPIB  

     
     
     Block miRNA regulation of human, mouse, rat PPIB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PPIB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPIB Predesigned siRNA for gene silencing in human, mouse, rat PPIB
     QuantiFast Probe-based Assays in human, mouse, rat PPIB QuantiTect SYBR Green Assays in human, mouse, rat PPIB
     Custom PCR Arrays for PPIB Search Chromatin IP Primers for PPIB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPIB  GeneGlobe Interaction Network for PPIB
     Regulatory tfbs in PPIB promoter
     GenScript Custom Purified and Recombinant Proteins Services for PPIB GenScript cDNA clones with any tag delivered in your preferred vector for PPIB
     GenScript Custom Assay Services for PPIB GenScript Custom overexpressing Cell Line Services for PPIB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PPIB
     Proteins for PPIB
     Cell Lysates for PPIB
     cDNA Clones for PPIB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PPIB antibodies
     PPIB proteins
     PPIB lysates
     Antibodies for PPIB
     See all of Abcam's Antibodies, Kits and Proteins for PPIB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PPIB
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for PPIB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIB
     SwitchGear 3'UTR luciferase reporter plasmids for PPIB
     SwitchGear Promoter luciferase reporter plasmids for PPIB
     ThermoFisher Antibody for PPIB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIB
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPIB
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPIB
     LSBio Antibodies in human, mouse, rat for PPIB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for PPIB
      Search eBioscience for proteins for PPIB
      Search eBioscience for elisas for PPIB
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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