Aliases for PPIB Gene
External Ids for PPIB Gene
Previous GeneCards Identifiers for PPIB Gene
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]
GeneCards Summary for PPIB Gene
PPIB (Peptidylprolyl Isomerase B) is a Protein Coding gene. Diseases associated with PPIB include Osteogenesis Imperfecta, Type Ix and Osteogenesis Imperfecta, Type Ii. Among its related pathways are Syndecan-1-mediated signaling events and Collagen chain trimerization. GO annotations related to this gene include poly(A) RNA binding and unfolded protein binding. An important paralog of this gene is PPIC.
UniProtKB/Swiss-Prot for PPIB Gene
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.