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Aliases for PPIAL4G Gene

Aliases for PPIAL4G Gene

  • Peptidylprolyl Isomerase A Like 4G 2 3
  • Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4G 3 5
  • Peptidylprolyl Cis-Trans Isomerase A-Like 4 3 4
  • PPIase A-Like 4G 3 4
  • Peptidylprolyl Cis-Trans Isomerase A-Like 4A 3
  • Peptidylprolyl Cis-Trans Isomerase A-Like 4G 3
  • Chromosome 1-Amplified Sequence 2 3
  • PPIase A-Like 4A 3
  • EC 5.2.1.8 4
  • COAS-2 3

External Ids for PPIAL4G Gene

Previous GeneCards Identifiers for PPIAL4G Gene

  • GC01M142557
  • GC01M143767

Summaries for PPIAL4G Gene

GeneCards Summary for PPIAL4G Gene

PPIAL4G (Peptidylprolyl Isomerase A Like 4G) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIAL4A.

UniProtKB/Swiss-Prot for PPIAL4G Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIAL4G Gene

Genomics for PPIAL4G Gene

Regulatory Elements for PPIAL4G Gene

Genomic Location for PPIAL4G Gene

Chromosome:
1
Start:
148,479,824 bp from pter
End:
148,483,679 bp from pter
Size:
3,856 bases
Orientation:
Minus strand

Genomic View for PPIAL4G Gene

Genes around PPIAL4G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIAL4G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIAL4G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIAL4G Gene

Proteins for PPIAL4G Gene

  • Protein details for PPIAL4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DN37-PAL4G_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A-like 4G
    Protein Accession:
    P0DN37
    Secondary Accessions:
    • A1L431
    • A2BFH1

    Protein attributes for PPIAL4G Gene

    Size:
    164 amino acids
    Molecular mass:
    18166 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.

neXtProt entry for PPIAL4G Gene

Proteomics data for PPIAL4G Gene at MOPED

Post-translational modifications for PPIAL4G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPIAL4G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPIAL4G Gene

Domains & Families for PPIAL4G Gene

Suggested Antigen Peptide Sequences for PPIAL4G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0DN37

UniProtKB/Swiss-Prot:

PAL4G_HUMAN :
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
genes like me logo Genes that share domains with PPIAL4G: view

No data available for Gene Families for PPIAL4G Gene

Function for PPIAL4G Gene

Molecular function for PPIAL4G Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Enzyme Numbers (IUBMB) for PPIAL4G Gene

Phenotypes for PPIAL4G Gene

genes like me logo Genes that share phenotypes with PPIAL4G: view

Animal Model Products

CRISPR Products

miRNA for PPIAL4G Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIAL4G Gene

Localization for PPIAL4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIAL4G Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIAL4G Gene COMPARTMENTS Subcellular localization image for PPIAL4G gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for PPIAL4G Gene

Pathways & Interactions for PPIAL4G Gene

SuperPathways for PPIAL4G Gene

No Data Available

Interacting Proteins for PPIAL4G Gene

Gene Ontology (GO) - Biological Process for PPIAL4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
genes like me logo Genes that share ontologies with PPIAL4G: view

No data available for Pathways by source and SIGNOR curated interactions for PPIAL4G Gene

Drugs & Compounds for PPIAL4G Gene

No Compound Related Data Available

Transcripts for PPIAL4G Gene

mRNA/cDNA for PPIAL4G Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPIAL4G Gene

Peptidylprolyl isomerase A (cyclophilin A)-like 4G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPIAL4G Gene

No ASD Table

Relevant External Links for PPIAL4G Gene

GeneLoc Exon Structure for
PPIAL4G
ECgene alternative splicing isoforms for
PPIAL4G

Expression for PPIAL4G Gene

mRNA expression in normal human tissues for PPIAL4G Gene

Protein differential expression in normal tissues from HIPED for PPIAL4G Gene

This gene is overexpressed in Brain (34.0), Skin (18.4), and Heart (16.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPIAL4G Gene



SOURCE GeneReport for Unigene cluster for PPIAL4G Gene Hs.534674

genes like me logo Genes that share expression patterns with PPIAL4G: view

Protein tissue co-expression partners for PPIAL4G Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPIAL4G Gene

Orthologs for PPIAL4G Gene

This gene was present in the common ancestor of animals.

Orthologs for PPIAL4G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100612700 35
  • 98.16 (n)
  • 95.09 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 82 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm12728 36
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves PPIA 36
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii PPIA 36
  • 1 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5071 36
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T22F3.12 36
  • 41 (a)
ManyToMany
Y17G9B.4 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2570 36
  • 5 (a)
OneToMany
Species with no ortholog for PPIAL4G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PPIAL4G Gene

ENSEMBL:
Gene Tree for PPIAL4G (if available)
TreeFam:
Gene Tree for PPIAL4G (if available)

Paralogs for PPIAL4G Gene

(22) SIMAP similar genes for PPIAL4G Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PPIAL4G Gene

genes like me logo Genes that share paralogs with PPIAL4G: view

Variants for PPIAL4G Gene

Sequence variations from dbSNP and Humsavar for PPIAL4G Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs385569 -- 148,482,167(+) TGTGA(A/G)ATGAC downstream-variant-500B
rs470439 -- 148,482,369(+) attag(A/G)gttca downstream-variant-500B
rs577592 -- 148,484,883(+) gcatt(C/T)gtatt upstream-variant-2KB
rs578490 -- 148,484,988(+) ctttc(C/T)gagtc upstream-variant-2KB
rs2999784 -- 148,483,504(+) ttatg(C/T)agtca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPIAL4G Gene

Variant ID Type Subtype PubMed ID
esv27827 CNV Gain 19812545

Variation tolerance for PPIAL4G Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.78; 94.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIAL4G Gene

HapMap Linkage Disequilibrium report
PPIAL4G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIAL4G Gene

Disorders for PPIAL4G Gene

Relevant External Links for PPIAL4G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPIAL4G

No disorders were found for PPIAL4G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIAL4G Gene

Publications for PPIAL4G Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PPIAL4G Gene

Sources for PPIAL4G Gene

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