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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PPIAL4G Gene

protein-coding GIFtS: 32
GCID: GC01M143767

Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4G

Search for PPIAL4G
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4G¹ ²		Peptidyl-Prolyl Cis-Trans Isomerase A-Like 4G²
Peptidylprolyl Cis-Trans Isomerase A-Like 4² ³		Peptidylprolyl Cis-Trans Isomerase A-Like 4A²
PPIase A-Like 4G² ³		Peptidylprolyl Cis-Trans Isomerase A-Like 4G²
BX284650.5²		PPIase A-Like 4A²
COAS-2²		EC 5.2.1.8³
Chromosome 1-Amplified Sequence 2²

External Ids:	HGNC: 33996¹	Entrez Gene: 644591²	Ensembl: ENSG00000236334⁷	UniProtKB: A2BFH1³

Export aliases for PPIAL4G gene to outside databases

Previous GC identifer: GC01M142557

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PPIAL4G Gene:

PPIAL4G (peptidylprolyl isomerase A (cyclophilin A)-like 4G) is a protein-coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIE.

UniProtKB/Swiss-Prot: PAL4G_HUMAN, A2BFH1

Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic

peptide bonds in oligopeptides (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NT_113797.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PPIAL4G gene promoter:
NF-1 NF-1/L HOXA3 C/EBPalpha PPAR-alpha POU2F1 Nkx6-1 POU2F1a ZIC2/Zic2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for PPIAL4G

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIAL4G

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1 Ensembl cytogenetic band: 1q21.1 HGNC cytogenetic band: 1q21.1

PPIAL4G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIAL4G gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M143767: view genomic region (about GC identifiers)

Start:	143,767,144 bp from pter	End:	143,767,881 bp from pter
Size:	738 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PAL4G_HUMAN, A2BFH1 (See protein sequence)

Recommended Name: Peptidyl-prolyl cis-trans isomerase A-like 4G

Size: 164 amino acids; 18166 Da

Subcellular location: Cytoplasm (By similarity)

Miscellaneous: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene

duplication, on chromosome 1

Secondary accessions: A1L431

Explore the universe of human proteins at neXtProt for PPIAL4G: NX_A2BFH1

Explore proteomics data for PPIAL4G at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_A2BFH1

PPIAL4G Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_001116540.1

ENSEMBL proteins:

ENSP00000393845

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

PPIAL4G for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro protein domains:

IPR002130 Cyclophilin-like_PPIase_dom

IPR024936 Cyclophilin-type_PPIase

IPR020892 Cyclophilin-type_PPIase_CS

Graphical View of Domain Structure for InterPro Entry A2BFH1

ProtoNet protein and cluster: A2BFH1

UniProtKB/Swiss-Prot: PAL4G_HUMAN, A2BFH1

Similarity: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily

Similarity: Contains 1 PPIase cyclophilin-type domain

PPIAL4G for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PAL4G_HUMAN, A2BFH1

Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic

peptide bonds in oligopeptides (By similarity)

Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

Enzyme Number (IUBMB): EC 5.2.1.8¹

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IEA	--

PPIAL4G for ontologies About GeneDecksing

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PPIAL4G

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for PPIAL4G (ENSP00000393845⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SGK1	ENSP00000356832⁴	STRING: ENSP00000356832

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006457	protein folding	IEA	--

PPIAL4G for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Search CenterWatch for drugs/clinical trials and news about PPIAL4G / PAL4G

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for PPIAL4G gene:

NM_001123068.1

Unigene Cluster for PPIAL4G:

Peptidylprolyl isomerase A (cyclophilin A)-like 4G

Hs.534674

Unigene Representative Sequence: NM_001123068

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000419275(uc001ejt.3)

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Additional mRNA sequence:

BC130376.1 BC130378.1

1 DOTS entry:

DT.100039874

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPIAL4G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

See PPIAL4G Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.534674

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PPIAL4G gene from 5/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
oppossum (Monodelphis domestica)	Mammalia	-- -- (see all 5)	Uncharacterized protein (see all 5)	80(a) 78(a) (see all 5)	many ↔ many many ↔ many (see all 5)	1(502617573-502622660) Un(38672129-38672623)
chicken (Gallus gallus)	Aves	-- -- (see all 3)	--	(see all 3)	possible ortholog possible ortholog (see all 3)	12(25698-75398) 1(139386530-139404977)
lizard (Anolis carolinensis)	Reptilia	-- --	Peptidyl-prolyl cis-trans isomerase	78(a)	possible ortholog 1 ↔ many	3(107454117-107504389) GL343238.1(667038-675712)
fruit fly (Drosophila melanogaster)	Insecta	CG5071⁶ Nup358⁶	Nucleoporin 358	6(a) 1(a)	possible ortholog possible ortholog	3R(21444136-21446401) 3R(21075316-21084394)
worm (Caenorhabditis elegans)	Secernentea	T22F3.12⁶ Y17G9B.4⁶ (see all 3)	Protein Y17G9B.4 (see all 3)	34(a) 17(a) (see all 3)	many ↔ many many ↔ many (see all 3)	V(3589029-3592199) IV(4752094-4753230)

ENSEMBL Gene Tree for PPIAL4G (if available)
TreeFam Gene Tree for PPIAL4G (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PPIAL4G gene

PPIAL4C¹ ² PPIAL4A¹ ² PPIAL4B¹ ² PPIAL4F PPIAL4D¹ ² PPIAL4E PPIE² RANBP2²

RGPD6² PPIF² PPIA² RGPD2² RGPD4² RGPD3² RGPD1² RGPD5²

RGPD8²

18/22 SIMAP similar genes for PPIAL4G using alignment to 1 protein entry: PAL4G_HUMAN(see all similar genes):

PPIAL4A PPIAL4B PPIAL4C PPIAL4D PPIA LOC402252

PPIF RANBP2 PPIE PPIC PPIB PPID

PPIH PPIL1 PPIL6 DKFZp686G0426 NKTR CWC27

PPIAL4G for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for PPIAL4G
PGOHUM00000234654 PGOHUM00000235579

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200645759^1,2	C	--	143767235(+)	`AAAGGA/GAACTG`	1	--	ut3¹		0	--	--	--	--
rs201606684^1,2	C	--	143767254(+)	`GCACAA/GAGATT`	1	--	ut3¹		0	--	--	--	--
rs200637303^1,2	C,F	--	143767312(+)	`CAGAAG/TGAATG`	1	--	ut3¹		1		EU	179
rs201648411^1,2	C	--	143767357(+)	`CATTAG/CAATTG`	2	/F /L	mis¹		1		EU	1177
rs77641628^1,2	C,F	--	143767466(+)	`CAAAGG/ACCACA`	2	/A /V	mis¹		2		NA EU	963
rs6604511^1,2	C,F,A	--	143767513(+)	`ATGAAT/AAACTG`	2	/L /F	mis¹		2		NA	6
rs6604512^1,2	C,F,A	--	143767522(+)	`TGGGAA/GCCATT`	2	G	syn¹		3		NA	8
rs2490183^1,2	C	--	143767547(+)	`CATTTA/GCCATG`	2	A V	mis¹		0	--	--	--	--
rs6604514^1,2	C,F,A	--	143767628(+)	`TGTCAC/TCGGTG`	2	D G	mis¹		1		EU	359
rs12407726^1,2	C,F,H	--	143767629(+)	`GTCACC/TGGTGC`	2	S G	mis¹		4		NS NA EU	1607

HapMap Linkage Disequilibrium report for PPIAL4G (143767144 - 143767881 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for PPIAL4G: About this table

Variant ID	Type	Subtype	PubMed ID
esv27827	CNV	Gain	19812545

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PPIAL4G gene integrated from 9 sources:
(articles sorted by number of sources associating them with PPIAL4G)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 644591	HGNC: 33996	Ensembl:ENSG00000236334	euGenes: HUgn644591	ECgene: PPIAL4G
H-InvDB: PPIAL4G

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PPIAL4G	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PPIAL4G gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PPIAL4G gene:
Search GeneIP for patents involving PPIAL4G

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Hot genes Disease genes PPIAL4G gene at Home site.

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PPIAL4G Gene

Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4G

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PPIAL4G Gene

Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4G

Aliasesfor PPIAL4G gene

Summariesfor PPIAL4G gene

Genomic Viewsfor PPIAL4G gene

Proteinsfor PPIAL4G gene

Protein Domains /Familiesfor PPIAL4G gene

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Genome Databases showing PPIAL4G gene

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Aliases
for PPIAL4G gene

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for PPIAL4G gene

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for PPIAL4G gene

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for PPIAL4G gene

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Families
for PPIAL4G gene

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for PPIAL4G gene

Pathways & Interactions
for PPIAL4G gene

Drugs & Compounds
for PPIAL4G gene

Transcripts
for PPIAL4G gene

Expression
for PPIAL4G gene

Orthologs
for PPIAL4G gene

Paralogs
for PPIAL4G gene

Genomic Variants
for PPIAL4G gene

Disorders / Diseases
for PPIAL4G gene

Publications
for PPIAL4G gene

Intellectual Property
for PPIAL4G gene

Products
for PPIAL4G gene