Aliases for PPIAL4G Gene
Aliases for PPIAL4G Gene
External Ids for PPIAL4G Gene
- HGNC: 33996
- Entrez Gene: 644591
- Ensembl: ENSG00000236334
- UniProtKB: P0DN37
Previous GeneCards Identifiers for PPIAL4G Gene
- GC01M142557
- GC01M143767
Summaries for PPIAL4G Gene
GeneCards Summary for PPIAL4G Gene
PPIAL4G (Peptidylprolyl Isomerase A Like 4G) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIAL4C.
UniProtKB/Swiss-Prot for PPIAL4G Gene
-
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIAL4G Gene
Genomics for PPIAL4G Gene
Regulatory Elements for PPIAL4G Gene
Enhancers for PPIAL4G Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G148480 | 0.4 | Ensembl | 0.7 | +2.4 | 2378 | 1.0 | CEBPB | PPIAL4G ENSG00000280649 |
| GH01G148502 | 0.4 | Ensembl | 0.4 | -19.0 | -19022 | 0.2 | SPI1 | GC01M148511 PPIAL4G |
| GH01G148482 | 0.2 | Ensembl | 0.7 | +1.5 | 1479 | 0.4 | PPIAL4G ENSG00000280649 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PPIAL4G on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PPIAL4G gene promoter:
Regulatory Element Products
Genomic Location for PPIAL4G Gene
- Chromosome:
- 1
- Start:
- 148,479,824 bp from pter
- End:
- 148,483,679 bp from pter
- Size:
- 3,856 bases
- Orientation:
- Minus strand
Genomic View for PPIAL4G Gene
Genes around PPIAL4G on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.2 by Ensembl
- 1q21.2 by Entrez Gene
- 1q21.2 by HGNC
PPIAL4G Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPIAL4G Gene
Proteins for PPIAL4G Gene
-
Protein details for PPIAL4G Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0DN37-PAL4G_HUMAN
- Recommended name:
- Peptidyl-prolyl cis-trans isomerase A-like 4G
- Protein Accession:
- P0DN37
- A1L431
- A2BFH1
Protein attributes for PPIAL4G Gene
- Size:
- 164 amino acids
- Molecular mass:
- 18166 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.
Protein Expression for PPIAL4G Gene
Post-translational modifications for PPIAL4G Gene
Other Protein References for PPIAL4G Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PPIAL4G
-
Abcam antibodies for PPIAL4G
- antibodies-online Antibodies for PPIAL4G: See all 10
- Search GeneTex for Antibodies for PPIAL4G
Protein Products
-
OriGene Purified Proteins for PPIAL4G
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- Search GeneTex for Proteins for PPIAL4G
No data available for DME Specific Peptides for PPIAL4G Gene
Domains & Families for PPIAL4G Gene
Protein Domains for PPIAL4G Gene
Suggested Antigen Peptide Sequences for PPIAL4G Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P0DN37UniProtKB/Swiss-Prot:
PAL4G_HUMAN :- Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
- Family:
-
- Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
No data available for Gene Families for PPIAL4G Gene
Function for PPIAL4G Gene
Molecular function for PPIAL4G Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Peptidylproline (omega=180) = peptidylproline (omega=0).
- UniProtKB/Swiss-Prot Function:
- PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Enzyme Numbers (IUBMB) for PPIAL4G Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | IEA | -- |
| GO:0016853 | isomerase activity | IEA | -- |
Phenotypes for PPIAL4G Gene
- GenomeRNAi human phenotypes for PPIAL4G:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for PPIAL4G gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PPIAL4G gene
- Search ViGene Biosciences for PPIAL4G
CRISPR Products
-
OriGene CRISPR knockouts for PPIAL4G
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPIAL4G
- GenScript: Design CRISPR guide RNA sequences for PPIAL4G
miRNA for PPIAL4G Gene
- miRTarBase miRNAs that target PPIAL4G
miRNA Products
- Search ViGene Biosciences for PPIAL4G
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for PPIAL4G
- Browse OriGene Inhibitory RNA Products For PPIAL4G
-
ViGene Biosciences ready-to-package AAV shRNAs for PPIAL4G gene
Clone Products
-
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- Addgene plasmids for PPIAL4G
- VectorBuilder custom plasmid, inducible vectors for PPIAL4G
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPIAL4G
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for PPIAL4G
-
ViGene Biosciences adenoviral particle packaged cDNA for PPIAL4G gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PPIAL4G gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PPIAL4G gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIAL4G Gene
Localization for PPIAL4G Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPIAL4G Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for PPIAL4G Gene
No Data Available
Interacting Proteins for PPIAL4G Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000413 | protein peptidyl-prolyl isomerization | IEA | -- |
| GO:0006457 | protein folding | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PPIAL4G Gene
Transcripts for PPIAL4G Gene
mRNA/cDNA for PPIAL4G Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PPIAL4G Gene
- Peptidylprolyl isomerase A (cyclophilin A)-like 4G:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PPIAL4G
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPIAL4G
- GenScript: Design CRISPR guide RNA sequences for PPIAL4G
miRNA Products
- Search ViGene Biosciences for PPIAL4G
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for PPIAL4G
- Browse OriGene Inhibitory RNA Products For PPIAL4G
-
ViGene Biosciences ready-to-package AAV shRNAs for PPIAL4G gene
Clone Products
-
OriGene ORF clones in human for PPIAL4G
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Addgene plasmids for PPIAL4G
- VectorBuilder custom plasmid, inducible vectors for PPIAL4G
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPIAL4G
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for PPIAL4G Gene
This gene is overexpressed in Brain (34.0), Skin (18.4), and Heart (16.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPIAL4G Gene
NURSA nuclear receptor signaling pathways regulating expression of PPIAL4G Gene:
PPIAL4GSOURCE GeneReport for Unigene cluster for PPIAL4G Gene:
Hs.534674Primer Products
-
OriGene qPCR primer pairs for PPIAL4G
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIAL4G Gene
Orthologs for PPIAL4G Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC100612700 34 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
ManyToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| mouse (Mus musculus) |
Mammalia | Gm12728 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | PPIA 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | PPIA 35 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG5071 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | T22F3.12 35 |
|
ManyToMany | |
| Y17G9B.4 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2570 35 |
|
OneToMany |
- Species where no ortholog for PPIAL4G was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for PPIAL4G Gene
Paralogs for PPIAL4G Gene
(22) SIMAP similar genes for PPIAL4G Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for PPIAL4G Gene
Variants for PPIAL4G Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs12563955 | -- | 148,483,774(+) | accac(A/G)cctgg | upstream-variant-2KB | |
| rs139394234 | -- | 148,483,574(+) | TTCTT(C/T)CTTTC | upstream-variant-2KB | |
| rs193142006 | -- | 148,484,666(+) | TTGTG(C/T)GTTGG | upstream-variant-2KB | |
| rs201223939 | -- | 148,483,055(+) | GTGAA(A/G)TCACC | reference, synonymous-codon | |
| rs202205675 | -- | 148,482,519(+) | TCCTG(A/G)CAACC | downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv190n106 | CNV | duplication | 24896259 |
| dgv327n100 | CNV | gain | 25217958 |
| dgv66e199 | CNV | deletion | 23128226 |
| esv2761299 | CNV | gain+loss | 21179565 |
| esv27827 | CNV | gain | 19812545 |
| nsv1003688 | CNV | gain | 25217958 |
| nsv1005055 | CNV | loss | 25217958 |
| nsv1076343 | CNV | duplication | 25765185 |
| nsv1118444 | CNV | duplication | 24896259 |
| nsv1132304 | CNV | duplication | 24896259 |
| nsv1151024 | CNV | duplication | 26484159 |
| nsv509457 | CNV | insertion | 20534489 |
| nsv510962 | OTHER | complex | 20534489 |
| nsv510984 | OTHER | inversion | 20534489 |
| nsv8225 | CNV | gain | 18304495 |
| nsv824509 | CNV | gain | 20364138 |
| nsv951870 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
12.78;
94.73% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PPIAL4G Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PPIAL4G
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIAL4G Gene
Disorders for PPIAL4G Gene
Relevant External Links for PPIAL4G
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- PPIAL4G
No disorders were found for PPIAL4G Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIAL4G Gene
Publications for PPIAL4G Gene
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
Products for PPIAL4G Gene
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- Custom Antibody ServicesOriGene Antibodies for PPIAL4G
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- OriGene Purified Proteins for PPIAL4G
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- OriGene qPCR primer pairs for PPIAL4G
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- ViGene Biosciences adenoviral particle packaged cDNA for PPIAL4G gene
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- Horizon Cell Lines for PPIAL4G
- Cyagen custom Knockout/knockin (KOKI) mouse models for PPIAL4G
- VectorBuilder custom plasmid, inducible vectors for PPIAL4G
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPIAL4G
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for PPIAL4G Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
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- (98) BioGPS
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- (100) COMPARTMENTS
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- (104) Addgene
- (105) antibodies-online
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- (107) NONCODE
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- (109) TreeFam
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- (146) Cyagen
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer