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Aliases for PPIAL4G Gene

Aliases for PPIAL4G Gene

  • Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4G 2 3
  • Peptidylprolyl Cis-Trans Isomerase A-Like 4 3 4
  • PPIase A-Like 4G 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase A-Like 4G 3
  • Peptidylprolyl Cis-Trans Isomerase A-Like 4A 3
  • Peptidylprolyl Cis-Trans Isomerase A-Like 4G 3
  • Chromosome 1-Amplified Sequence 2 3
  • PPIase A-Like 4A 3
  • EC 4
  • COAS-2 3

External Ids for PPIAL4G Gene

Previous GeneCards Identifiers for PPIAL4G Gene

  • GC01M142557
  • GC01M143767

Summaries for PPIAL4G Gene

GeneCards Summary for PPIAL4G Gene

PPIAL4G (Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4G) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIE.

UniProtKB/Swiss-Prot for PPIAL4G Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIAL4G Gene

Genomics for PPIAL4G Gene

Regulatory Elements for PPIAL4G Gene

Genomic Location for PPIAL4G Gene

148,479,824 bp from pter
148,483,679 bp from pter
3,856 bases
Minus strand

Genomic View for PPIAL4G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIAL4G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIAL4G Gene

Proteins for PPIAL4G Gene

  • Protein details for PPIAL4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A-like 4G
    Protein Accession:
    Secondary Accessions:
    • A1L431

    Protein attributes for PPIAL4G Gene

    164 amino acids
    Molecular mass:
    18166 Da
    Quaternary structure:
    No Data Available
    • It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1

neXtProt entry for PPIAL4G Gene

Proteomics data for PPIAL4G Gene at MOPED

Post-translational modifications for PPIAL4G Gene

  • Glycosylation at Asn108
  • Modification sites at PhosphoSitePlus

Other Protein References for PPIAL4G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPIAL4G Gene

Domains for PPIAL4G Gene

Suggested Antigen Peptide Sequences for PPIAL4G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • A2BFH1
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
genes like me logo Genes that share domains with PPIAL4G: view

No data available for Gene Families for PPIAL4G Gene

Function for PPIAL4G Gene

Molecular function for PPIAL4G Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Enzyme Numbers (IUBMB) for PPIAL4G Gene

Gene Ontology (GO) - Molecular Function for PPIAL4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
genes like me logo Genes that share ontologies with PPIAL4G: view

Animal Model Products

CRISPR Products

miRNA for PPIAL4G Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPIAL4G Gene

Localization for PPIAL4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIAL4G Gene


Gene Ontology (GO) - Cellular Components for PPIAL4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPIAL4G: view

No data available for Subcellular locations from COMPARTMENTS for PPIAL4G Gene

Pathways for PPIAL4G Gene

SuperPathways for PPIAL4G Gene

No Data Available

Interacting Proteins for PPIAL4G Gene

Gene Ontology (GO) - Biological Process for PPIAL4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PPIAL4G: view

No data available for Pathways by source for PPIAL4G Gene

Transcripts for PPIAL4G Gene

mRNA/cDNA for PPIAL4G Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPIAL4G Gene

Peptidylprolyl isomerase A (cyclophilin A)-like 4G:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPIAL4G

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PPIAL4G
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIAL4G Gene

No ASD Table

Relevant External Links for PPIAL4G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIAL4G Gene

mRNA expression in normal human tissues for PPIAL4G Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PPIAL4G Gene

SOURCE GeneReport for Unigene cluster for PPIAL4G Gene Hs.534674

genes like me logo Genes that share expressions with PPIAL4G: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPIAL4G Gene

Orthologs for PPIAL4G Gene

This gene was present in the common ancestor of animals.

Orthologs for PPIAL4G Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100612700 35
  • 98.16 (n)
  • 95.09 (a)
(Canis familiaris)
Mammalia -- 36
  • 82 (a)
(Mus musculus)
Mammalia Gm12728 36
  • 66 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
(Gallus gallus)
Aves PPIA 36
  • 80 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
(Danio rerio)
Actinopterygii PPIA 36
  • 1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 36
  • 6 (a)
(Caenorhabditis elegans)
Secernentea T22F3.12 36
  • 41 (a)
Y17G9B.4 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2570 36
  • 5 (a)
Species with no ortholog for PPIAL4G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PPIAL4G Gene

Gene Tree for PPIAL4G (if available)
Gene Tree for PPIAL4G (if available)

Paralogs for PPIAL4G Gene

Selected SIMAP similar genes for PPIAL4G Gene using alignment to 1 proteins: Pseudogenes for PPIAL4G Gene

genes like me logo Genes that share paralogs with PPIAL4G: view

Variants for PPIAL4G Gene

Sequence variations from dbSNP and Humsavar for PPIAL4G Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs577592 -- 148,484,883(+) gcatt(C/T)gtatt upstream-variant-2KB
rs578490 -- 148,484,988(+) ctttc(C/T)gagtc upstream-variant-2KB
rs3977399 -- 148,484,977(+) tcagt(C/G)tttgt upstream-variant-2KB
rs6694367 -- 148,482,716(+) CAGAA(G/T)GAATG utr-variant-3-prime
rs75097387 -- 148,483,511(+) GTCAC(C/T)TATTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPIAL4G Gene

Variant ID Type Subtype PubMed ID
esv27827 CNV Gain 19812545

Relevant External Links for PPIAL4G Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIAL4G Gene

Disorders for PPIAL4G Gene

No disorders were found for PPIAL4G Gene.

No data available for UniProtKB/Swiss-Prot for PPIAL4G Gene

Publications for PPIAL4G Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for PPIAL4G Gene

Sources for PPIAL4G Gene

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