Aliases for PPIAL4G Gene
Aliases for PPIAL4G Gene
External Ids for PPIAL4G Gene
- HGNC: 33996
- Entrez Gene: 644591
- Ensembl: ENSG00000236334
- UniProtKB: P0DN37
Previous GeneCards Identifiers for PPIAL4G Gene
- GC01M142557
- GC01M143767
Summaries for PPIAL4G Gene
GeneCards Summary for PPIAL4G Gene
PPIAL4G (Peptidylprolyl Isomerase A Like 4G) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIAL4C.
UniProtKB/Swiss-Prot for PPIAL4G Gene
-
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Additional gene information for PPIAL4G Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIAL4G Gene
Genomics for PPIAL4G Gene
GeneHancer (GH) Regulatory Elements for PPIAL4G Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01I148482 | Enhancer | 0.2 | Ensembl | 550.8 | +1.5 | 1478 | 0.4 | PPIAL4G ENSG00000280649 LINC01138 | ||
GH01I148458 | Promoter | 1.2 | Ensembl | 0.3 | +24.2 | 24178 | 3 | SIN3A FEZF1 GLIS2 ELK1 SP3 REST SMARCA4 GLIS1 MYNN NBN | ENSG00000280649 PPIAL4G LINC01138 | |
GH01I148480 | Enhancer | 0.3 | Ensembl | 0.8 | +2.4 | 2378 | 1 | CEBPB | PPIAL4G ENSG00000280649 LINC01138 | |
GH01I148502 | Enhancer | 0.3 | Ensembl | 0.4 | -19.0 | -19022 | 0.2 | SPI1 | GC01M148511 LINC01138 PPIAL4G |
- Top Transcription factor binding sites by QIAGEN in the PPIAL4G gene promoter:
Regulatory Element Products
Genomic Locations for PPIAL4G Gene
- chr1:148,479,824-148,483,679
- (GRCh38/hg38)
- Size:
- 3,856 bases
- Orientation:
- Minus strand
- chr1:143,767,144-143,767,881
- (GRCh37/hg19)
Genomic View for PPIAL4G Gene
- Cytogenetic band:
-
- 1q21.2 by Ensembl
- 1q21.2 by Entrez Gene
- 1q21.2 by HGNC


RefSeq DNA sequence for PPIAL4G Gene
Proteins for PPIAL4G Gene
-
Protein details for PPIAL4G Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0DN37-PAL4G_HUMAN
- Recommended name:
- Peptidyl-prolyl cis-trans isomerase A-like 4G
- Protein Accession:
- P0DN37
- A1L431
- A2BFH1
Protein attributes for PPIAL4G Gene
- Size:
- 164 amino acids
- Molecular mass:
- 18166 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.
Protein Expression for PPIAL4G Gene
Post-translational modifications for PPIAL4G Gene
Other Protein References for PPIAL4G Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Protein Products
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Assay Products
No data available for DME Specific Peptides for PPIAL4G Gene
Domains & Families for PPIAL4G Gene
Gene Families for PPIAL4G Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PPIAL4G Gene
Suggested Antigen Peptide Sequences for PPIAL4G Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P0DN37UniProtKB/Swiss-Prot:
PAL4G_HUMAN :- Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
- Family:
-
- Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
Function for PPIAL4G Gene
Molecular function for PPIAL4G Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Peptidylproline (omega=180) = peptidylproline (omega=0).
- UniProtKB/Swiss-Prot Function:
- PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
Enzyme Numbers (IUBMB) for PPIAL4G Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | IEA | -- |
GO:0016853 | isomerase activity | IEA | -- |
Phenotypes for PPIAL4G Gene
- GenomeRNAi human phenotypes for PPIAL4G:
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-
-
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-
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- Search ViGene Biosciences for PPIAL4G
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-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPIAL4G
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miRNA for PPIAL4G Gene
- miRTarBase miRNAs that target PPIAL4G
miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PPIAL4G
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-
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-
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-
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No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPIAL4G Gene
Localization for PPIAL4G Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPIAL4G Gene
- Cytoplasm.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPIAL4G Gene
Pathways & Interactions for PPIAL4G Gene
Interacting Proteins for PPIAL4G Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000413 | protein peptidyl-prolyl isomerization | IEA | -- |
GO:0006457 | protein folding | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PPIAL4G Gene
Transcripts for PPIAL4G Gene
mRNA/cDNA for PPIAL4G Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PPIAL4G Gene
- Peptidylprolyl isomerase A (cyclophilin A)-like 4G:
- Representative Sequences:
CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPIAL4G
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miRNA Products
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Inhibitory RNA Products
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Clone Products
- VectorBuilder custom plasmid, inducible vectors for PPIAL4G
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PPIAL4G
- Applied Biological Materials Clones for PPIAL4G
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PPIAL4G Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPIAL4G Gene
NURSA nuclear receptor signaling pathways regulating expression of PPIAL4G Gene:
PPIAL4GSOURCE GeneReport for Unigene cluster for PPIAL4G Gene:
Hs.534674Primer Products
-
OriGene qPCR primer pairs for PPIAL4G
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPIAL4G Gene
Orthologs for PPIAL4G Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | LOC100612700 33 |
|
||
dog (Canis familiaris) |
Mammalia | -- 34 |
|
ManyToMany | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
mouse (Mus musculus) |
Mammalia | Gm12728 34 |
|
OneToMany | |
chicken (Gallus gallus) |
Aves | PPIA 34 |
|
OneToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
zebrafish (Danio rerio) |
Actinopterygii | PPIA 34 |
|
OneToMany | |
fruit fly (Drosophila melanogaster) |
Insecta | CG5071 34 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | T22F3.12 34 |
|
ManyToMany | |
Y17G9B.4 34 |
|
ManyToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2570 34 |
|
OneToMany |
- Species where no ortholog for PPIAL4G was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for PPIAL4G Gene
Paralogs for PPIAL4G Gene
(22) SIMAP similar genes for PPIAL4G Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for PPIAL4G Gene
Variants for PPIAL4G Gene
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs111334863 | -- | 148,482,247(-) | C/T | downstream_transcript_variant | |
rs11485934 | -- | 148,484,940(-) | C/T | upstream_transcript_variant | |
rs11488510 | -- | 148,484,988(-) | T/C | upstream_transcript_variant | |
rs12407726 | -- | 148,483,033(-) | C/T | coding_sequence_variant, missense_variant | |
rs12563955 | -- | 148,483,774(-) | G/A/T | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv190n106 | CNV | duplication | 24896259 |
dgv327n100 | CNV | gain | 25217958 |
dgv66e199 | CNV | deletion | 23128226 |
esv2761299 | CNV | gain+loss | 21179565 |
esv27827 | CNV | gain | 19812545 |
nsv1003688 | CNV | gain | 25217958 |
nsv1005055 | CNV | loss | 25217958 |
nsv1076343 | CNV | duplication | 25765185 |
nsv1118444 | CNV | duplication | 24896259 |
nsv1132304 | CNV | duplication | 24896259 |
nsv1151024 | CNV | duplication | 26484159 |
nsv509457 | CNV | insertion | 20534489 |
nsv510962 | OTHER | complex | 20534489 |
nsv510984 | OTHER | inversion | 20534489 |
nsv8225 | CNV | gain | 18304495 |
nsv824509 | CNV | gain | 20364138 |
nsv951870 | CNV | duplication | 24416366 |
Additional Variant Information for PPIAL4G Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PPIAL4G
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIAL4G Gene
Disorders for PPIAL4G Gene
Additional Disease Information for PPIAL4G
No disorders were found for PPIAL4G Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIAL4G Gene
Publications for PPIAL4G Gene
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
Products for PPIAL4G Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PPIAL4G
- antibodies-online: Search results for 10 available PPIAL4G Antibodies ranked by validation data
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Sources for PPIAL4G Gene
- (1) GeneCards
- (2) HGNC
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- (4) Swiss-Prot
- (5) Ensembl
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- (7) GeneLoc
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- (10) PhosphoSitePlus
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