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Aliases for PPIAL4D Gene

Aliases for PPIAL4D Gene

  • Peptidylprolyl Isomerase A Like 4D 2 3
  • Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4D 5
  • PPIase A-Like 4D 4
  • EC 4

External Ids for PPIAL4D Gene

Previous GeneCards Identifiers for PPIAL4D Gene

  • GC01M146569
  • GC01M148202

Summaries for PPIAL4D Gene

GeneCards Summary for PPIAL4D Gene

PPIAL4D (Peptidylprolyl Isomerase A Like 4D) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIAL4A.

UniProtKB/Swiss-Prot for PPIAL4D Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIAL4D Gene

Genomics for PPIAL4D Gene

Regulatory Elements for PPIAL4D Gene

Enhancers for PPIAL4D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPIAL4D on UCSC Golden Path with GeneCards custom track

Promoters for PPIAL4D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPIAL4D on UCSC Golden Path with GeneCards custom track

Genomic Location for PPIAL4D Gene

145,241,415 bp from pter
145,242,199 bp from pter
785 bases
Minus strand

Genomic View for PPIAL4D Gene

Genes around PPIAL4D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIAL4D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIAL4D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIAL4D Gene

Proteins for PPIAL4D Gene

  • Protein details for PPIAL4D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A-like 4D
    Protein Accession:

    Protein attributes for PPIAL4D Gene

    164 amino acids
    Molecular mass:
    18167 Da
    Quaternary structure:
    No Data Available
    • It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.

neXtProt entry for PPIAL4D Gene

Proteomics data for PPIAL4D Gene at MOPED

Post-translational modifications for PPIAL4D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPIAL4D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPIAL4D Gene

Domains & Families for PPIAL4D Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
genes like me logo Genes that share domains with PPIAL4D: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for PPIAL4D Gene

Function for PPIAL4D Gene

Molecular function for PPIAL4D Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Enzyme Numbers (IUBMB) for PPIAL4D Gene

Phenotypes for PPIAL4D Gene

genes like me logo Genes that share phenotypes with PPIAL4D: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PPIAL4D Gene

Localization for PPIAL4D Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIAL4D Gene


No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PPIAL4D Gene

Pathways & Interactions for PPIAL4D Gene

SuperPathways for PPIAL4D Gene

No Data Available

Interacting Proteins for PPIAL4D Gene

Gene Ontology (GO) - Biological Process for PPIAL4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
genes like me logo Genes that share ontologies with PPIAL4D: view

No data available for Pathways by source and SIGNOR curated interactions for PPIAL4D Gene

Drugs & Compounds for PPIAL4D Gene

No Compound Related Data Available

Transcripts for PPIAL4D Gene

mRNA/cDNA for PPIAL4D Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PPIAL4D Gene

No ASD Table

Relevant External Links for PPIAL4D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIAL4D Gene

mRNA expression in normal human tissues for PPIAL4D Gene

mRNA differential expression in normal tissues according to GTEx for PPIAL4D Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x10.4), Whole Blood (x7.0), Spleen (x5.0), and Brain - Cerebellum (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPIAL4D Gene

SOURCE GeneReport for Unigene cluster for PPIAL4D Gene Hs.730589

genes like me logo Genes that share expression patterns with PPIAL4D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PPIAL4D Gene

Orthologs for PPIAL4D Gene

This gene was present in the common ancestor of animals.

Orthologs for PPIAL4D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100612700 35
  • 97.55 (n)
  • 94.48 (a)
(Bos Taurus)
Mammalia PPIA 36
  • 85 (a)
(Canis familiaris)
Mammalia -- 36
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
(Mus musculus)
Mammalia Gm12728 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
(Gallus gallus)
Aves PPIA 36
  • 80 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
(Danio rerio)
Actinopterygii PPIA 36
  • 1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 36
  • 6 (a)
(Caenorhabditis elegans)
Secernentea T22F3.12 36
  • 42 (a)
Y17G9B.4 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2570 36
  • 5 (a)
Species with no ortholog for PPIAL4D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PPIAL4D Gene

Gene Tree for PPIAL4D (if available)
Gene Tree for PPIAL4D (if available)

Paralogs for PPIAL4D Gene

(23) SIMAP similar genes for PPIAL4D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPIAL4D: view

Variants for PPIAL4D Gene

Sequence variations from dbSNP and Humsavar for PPIAL4D Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs407582 -- 145,240,934(+) GATGT(A/C)AAGGC downstream-variant-500B
rs4126086 -- 145,241,530(-) AATCT(C/T)TGTGC utr-variant-3-prime
rs61809243 -- 145,241,700(+) GCTCC(A/G)TGGCT reference, missense
rs61809244 -- 145,242,638(+) ACCAC(A/G)CCTGG upstream-variant-2KB
rs61809245 -- 145,243,611(+) CCTAT(A/G)TGTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPIAL4D Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
dgv117e1 CNV Complex 17122850
esv2750803 CNV Gain 17911159
nsv428235 CNV Gain 18775914
dgv118e1 CNV Complex 17122850
dgv120e1 CNV Complex 17122850
dgv7e55 CNV Loss 17911159
esv2750807 CNV Gain 17911159
dgv357n71 CNV Gain 21882294
esv2717607 CNV Deletion 23290073
dgv122e1 CNV Complex 17122850
nsv872291 CNV Gain 21882294
esv29002 CNV Gain 19812545
nsv824509 CNV Gain 20364138
nsv508604 CNV Loss 20534489
esv33539 CNV Gain+Loss 17666407
nsv872293 CNV Loss 21882294
nsv872294 CNV Gain 21882294
essv6701 CNV CNV 17122850
dgv123e1 CNV Complex 17122850
esv22150 CNV Gain 19812545
nsv433349 CNV Gain 18776910
nsv872295 CNV Loss 21882294
nsv831459 CNV Gain 17160897

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for PPIAL4D Gene

Disorders for PPIAL4D Gene

Relevant External Links for PPIAL4D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PPIAL4D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIAL4D Gene

Publications for PPIAL4D Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 67

Products for PPIAL4D Gene

Sources for PPIAL4D Gene