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Aliases for PPIAL4D Gene

Aliases for PPIAL4D Gene

  • Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4D 2 3
  • PPIase A-Like 4D 4
  • EC 4

External Ids for PPIAL4D Gene

Previous GeneCards Identifiers for PPIAL4D Gene

  • GC01M146569
  • GC01M148202

Summaries for PPIAL4D Gene

GeneCards Summary for PPIAL4D Gene

PPIAL4D (Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4D) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIE.

UniProtKB/Swiss-Prot for PPIAL4D Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIAL4D Gene

Genomics for PPIAL4D Gene

Genomic Location for PPIAL4D Gene

145,241,415 bp from pter
145,242,199 bp from pter
785 bases
Minus strand

Genomic View for PPIAL4D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIAL4D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIAL4D Gene

No data available for Regulatory Elements for PPIAL4D Gene

Proteins for PPIAL4D Gene

  • Protein details for PPIAL4D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A-like 4D
    Protein Accession:
    Secondary Accessions:

    Protein attributes for PPIAL4D Gene

    164 amino acids
    Molecular mass:
    18167 Da
    Quaternary structure:
    No Data Available
    • It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1

neXtProt entry for PPIAL4D Gene

Proteomics data for PPIAL4D Gene at MOPED

Post-translational modifications for PPIAL4D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPIAL4D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPIAL4D Gene

Domains for PPIAL4D Gene

Graphical View of Domain Structure for InterPro Entry



  • F5H284
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
genes like me logo Genes that share domains with PPIAL4D: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for PPIAL4D Gene

Function for PPIAL4D Gene

Molecular function for PPIAL4D Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Enzyme Numbers (IUBMB) for PPIAL4D Gene

Gene Ontology (GO) - Molecular Function for PPIAL4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
genes like me logo Genes that share ontologies with PPIAL4D: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PPIAL4D Gene

Localization for PPIAL4D Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIAL4D Gene


Subcellular locations from

Jensen Localization Image for PPIAL4D Gene COMPARTMENTS Subcellular localization image for PPIAL4D gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PPIAL4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPIAL4D: view

Pathways for PPIAL4D Gene

SuperPathways for PPIAL4D Gene

No Data Available

Interacting Proteins for PPIAL4D Gene

Gene Ontology (GO) - Biological Process for PPIAL4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PPIAL4D: view

No data available for Pathways by source for PPIAL4D Gene

Transcripts for PPIAL4D Gene

mRNA/cDNA for PPIAL4D Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPIAL4D

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIAL4D Gene

No ASD Table

Relevant External Links for PPIAL4D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIAL4D Gene

mRNA expression in normal human tissues for PPIAL4D Gene

mRNA differential expression in normal tissues according to GTEx for PPIAL4D Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (10.4), Whole Blood (7.0), Spleen (5.0), and Brain - Cerebellum (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PPIAL4D Gene

SOURCE GeneReport for Unigene cluster for PPIAL4D Gene Hs.730589

genes like me logo Genes that share expressions with PPIAL4D: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PPIAL4D Gene

Orthologs for PPIAL4D Gene

This gene was present in the common ancestor of animals.

Orthologs for PPIAL4D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100612700 35
  • 97.55 (n)
  • 94.48 (a)
(Bos Taurus)
Mammalia PPIA 36
  • 85 (a)
(Canis familiaris)
Mammalia -- 36
  • 72 (a)
(Mus musculus)
Mammalia Gm12728 36
  • 68 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
(Gallus gallus)
Aves PPIA 36
  • 80 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
(Danio rerio)
Actinopterygii PPIA 36
  • 1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5071 36
  • 6 (a)
(Caenorhabditis elegans)
Secernentea T22F3.12 36
  • 42 (a)
Y17G9B.4 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2570 36
  • 5 (a)
Species with no ortholog for PPIAL4D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PPIAL4D Gene

Gene Tree for PPIAL4D (if available)
Gene Tree for PPIAL4D (if available)

Paralogs for PPIAL4D Gene

Selected SIMAP similar genes for PPIAL4D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPIAL4D: view

Variants for PPIAL4D Gene

Sequence variations from dbSNP and Humsavar for PPIAL4D Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2451641 -- 145,241,798(+) TGGGA(A/G)CCATT synonymous-codon, reference
rs4126086 -- 145,241,530(-) AATCT(C/T)TGTGC utr-variant-3-prime
rs28424230 -- 145,241,823(-) CATGG(C/T)AAATG reference, missense
rs28451165 -- 145,242,219(-) TATAC(A/G)ACACT upstream-variant-2KB
rs28452211 -- 145,242,185(-) ACAGT(A/G)AAAAG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PPIAL4D Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
dgv117e1 CNV Complex 17122850
esv2750803 CNV Gain 17911159
nsv428235 CNV Gain 18775914
dgv118e1 CNV Complex 17122850
dgv120e1 CNV Complex 17122850
dgv7e55 CNV Loss 17911159
esv2750807 CNV Gain 17911159
dgv357n71 CNV Gain 21882294
esv2717607 CNV Deletion 23290073
dgv122e1 CNV Complex 17122850
nsv872291 CNV Gain 21882294
esv29002 CNV Gain 19812545
nsv824509 CNV Gain 20364138
nsv508604 CNV Loss 20534489
esv33539 CNV Gain+Loss 17666407
nsv872293 CNV Loss 21882294
nsv872294 CNV Gain 21882294
essv6701 CNV CNV 17122850
dgv123e1 CNV Complex 17122850
esv22150 CNV Gain 19812545
nsv433349 CNV Gain 18776910
nsv872295 CNV Loss 21882294
nsv831459 CNV Gain 17160897

Relevant External Links for PPIAL4D Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIAL4D Gene

Disorders for PPIAL4D Gene

No disorders were found for PPIAL4D Gene.

No data available for UniProtKB/Swiss-Prot for PPIAL4D Gene

Publications for PPIAL4D Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for PPIAL4D Gene

Sources for PPIAL4D Gene

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