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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPIAL4D Gene

protein-coding   GIFtS: 27
GCID: GC01M148202          (predicted)

Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4D

  Search for PPIAL4D
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4D1 2
PPIase A-Like 4D2 3
Peptidyl-Prolyl Cis-Trans Isomerase A-Like 4D2
EC 5.2.1.83

External Ids:    HGNC: 339981   Entrez Gene: 6451422   Ensembl: ENSG000002563747   UniProtKB: F5H2843   

Export aliases for PPIAL4D gene to outside databases

Previous GC identifer: GC01M146569


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PPIAL4D Gene: 
PPIAL4D (peptidylprolyl isomerase A (cyclophilin A)-like 4D) is a protein-coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIE.

UniProtKB/Swiss-Prot: PAL4D_HUMAN, F5H284
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_113799.1  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for PPIAL4D
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PPIAL4D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIAL4D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21

PPIAL4D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIAL4D gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M148202:  view genomic region     (about GC identifiers)

Start:
148,201,752 bp from pter      End:
148,202,536 bp from pter
Size:
785 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PAL4D_HUMAN, F5H284 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase A-like 4D  
Size: 164 amino acids; 18167 Da
Subcellular location: Cytoplasm (By similarity)
Miscellaneous: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene
duplication, on chromosome 1

Explore the universe of human proteins at neXtProt for PPIAL4D: NX_F5H284

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_F5H284

  • PPIAL4D Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001157733.1  
    ENSEMBL proteins: 
     ENSP00000439444  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    PPIAL4D for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002130 Cyclophilin-like_PPIase_dom
     IPR024936 Cyclophilin-type_PPIase
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry F5H284

    ProtoNet protein and cluster: F5H284

    UniProtKB/Swiss-Prot: PAL4D_HUMAN, F5H284
    Similarity: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily
    Similarity: Contains 1 PPIase cyclophilin-type domain


    PPIAL4D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAL4D_HUMAN, F5H284
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides (By similarity)
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

         Enzyme Number (IUBMB): EC 5.2.1.81

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IEA--
         
    PPIAL4D for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPIAL4D

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--

    PPIAL4D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPIAL4D (PAL4D)

    Search CenterWatch for drugs/clinical trials and news about PPIAL4D / PAL4D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPIAL4D gene: 
    NM_001164261.1  

    Unigene Cluster for PPIAL4D:

    Peptidylprolyl isomerase A (cyclophilin A)-like 4D
    Hs.730589
    Unigene Representative Sequence: NM_001164261
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000544708(uc010pag.2)
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPIAL4D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PPIAL4D Expression
    About this image


    SOURCE GeneReport for Unigene cluster: Hs.730589
        SABiosciences Custom PCR Arrays for PPIAL4D
    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PPIAL4D gene from 5/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    (see all 5)
    Uncharacterized protein
    (see all 5)
    79(a)
    77(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    1(502617573-502622660)
    Un(38672129-38672623)
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 3)
    --


    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    1(139386530-139404977)
    12(25698-75398)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Peptidyl-prolyl cis-trans isomerase

    78(a)
    possible ortholog
    1 ↔ many
    3(107454117-107504389)
    GL343238.1(667038-675712)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50716
    Nup3586
    Nucleoporin 358
    6(a)
    1(a)
    possible ortholog
    possible ortholog
    3R(21444136-21446401)
    3R(21075316-21084394)
    worm
    (Caenorhabditis elegans)
    Secernentea T22F3.126
    Y17G9B.46
    (see all 3)
    Protein Y17G9B.4
    (see all 3)
    35(a)
    18(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    V(3589029-3592199)
    IV(4752094-4753230)


    ENSEMBL Gene Tree for PPIAL4D (if available)
    TreeFam Gene Tree for PPIAL4D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPIAL4D gene
    PPIAL4F  PPIAL4E  PPIAL4C1 2  PPIAL4A1 2  PPIAL4B1 2  PPIAL4G1 2  PPIE2  RANBP22  
    RGPD62  PPIF2  PPIA2  RGPD22  RGPD42  RGPD32  RGPD12  RGPD52  
    RGPD82  
    18/23 SIMAP similar genes for PPIAL4D using alignment to 1 protein entry:     PAL4D_HUMAN(see all similar genes):
    PPIAL4A    PPIAL4B    PPIAL4C    PPIAL4G    PPIA    LOC402252
    PPIF    RANBP2    PPIE    PPIC    PPIB    PPIL1
    PPID    PPIH    DKFZp686G0426    PPWD1    PPIL6    NKTR

    PPIAL4D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10 SNPs in PPIAL4D are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1422405151,2
    C--148203960(+) CCTATA/GTGTAT 1 -- us2k10--------
    rs2010108101,2
    ----148202848(+) TTTTTG/TGAGAC 1 -- us2k10--------
    rs2016087321,2
    ----148202701(+) CCACAG/TTTTGC 1 -- us2k10--------
    rs3748063591,2
    ----148202986(+) CACCAC/TCCTGG 1 -- us2k10--------
    rs3712741061,2
    ----148203113(+) CATGCA/CCAGTG 1 -- us2k10--------
    rs2017648141,2
    ----148202241(+) TGTCAC/TCGGTG 2 D G mis10--------
    rs2000718581,2
    ----148202664(+) CTTTTA/GGCACT 1 -- us2k10--------
    rs3701351971,2
    ----148202556(+) AGTGTC/TTATAG 1 -- us2k10--------
    rs3774744681,2
    ----148202522(+) CTTTTC/TCTGTC 1 -- ut510--------
    rs3763949201,2
    ----148202987(+) ACCACA/GCTGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPIAL4D (148201752 - 148202536 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/24 variations for PPIAL4D (see all 24):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2717607CNV Deletion23290073
    nsv872295CNV Loss21882294
    dgv7e55CNV Loss17911159
    nsv508604CNV Loss20534489
    nsv872293CNV Loss21882294
    nsv428235CNV Gain18775914
    nsv824509CNV Gain20364138
    dgv357n71CNV Gain21882294
    esv29002CNV Gain19812545
    esv2750807CNV Gain17911159

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed article for PPIAL4D gene integrated from 9 sources:
    (articles sorted by number of sources associating them with PPIAL4D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 645142 HGNC: 33998 Ensembl:ENSG00000256374 euGenes: HUgn645142 ECgene: PPIAL4D
    H-InvDB: PPIAL4D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPIAL4D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPIAL4D gene:
    Search GeneIP for patents involving PPIAL4D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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