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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPIAL4C Gene

protein-coding   GIFtS: 35
GCID: GC01P149552          (predicted)

Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4C

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4C1 2     EC 5.2.1.83 8
Chromosome 1-Amplified Sequence 22 3     Peptidyl-Prolyl Cis-Trans Isomerase A-Like 4A/B/C2
Cyclophilin Homolog Overexpressed In Liver Cancer2 3     Peptidylprolyl Cis-Trans Isomerase A-Like 4A/B/C2
COAS-22 3     COAS23
PPIase A-Like 4A2 3     

External Ids:    HGNC: 339951   Entrez Gene: 6535982   Ensembl: ENSG000001981617   UniProtKB: Q9Y5363   

Export aliases for PPIAL4C gene to outside databases

Previous GC identifer: GC01P147821


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PPIAL4C Gene: 
PPIAL4C (peptidylprolyl isomerase A (cyclophilin A)-like 4C) is a protein-coding gene. Diseases associated with PPIAL4C include liposarcoma, and osteosarcoma. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIE.

UniProtKB/Swiss-Prot: PAL4A_HUMAN, Q9Y536
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPIAL4C gene promoter:
         Nkx3-1   NF-1/L   NF-1   Pbx1a   Nkx3-1 v1   Nkx2-5   CUTL1   PPAR-alpha   S8   ZIC2/Zic2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PPIAL4C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIAL4C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21

PPIAL4C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIAL4C gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P149552:  view genomic region     (about GC identifiers)

Start:
149,553,003 bp from pter      End:
149,553,787 bp from pter
Size:
785 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PAL4A_HUMAN, Q9Y536 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C  
Size: 164 amino acids; 18182 Da
Subcellular location: Cytoplasm (By similarity)
Miscellaneous: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene
duplication, on chromosome 1

Explore the universe of human proteins at neXtProt for PPIAL4C: NX_Q9Y536

Explore proteomics data for PPIAL4C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y536

  • 4/9 DME Specific Peptides for PPIAL4C (Q9Y536) (see all 9)
     GILSMAN  PKTAENF  LSMANAG  SIYGEKF 

    PPIAL4C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPIAL4C Protein Expression
    REFSEQ proteins: NP_001129261.1  
    ENSEMBL proteins: 
     ENSP00000358224  

    Human Recombinant Protein Products for PPIAL4C: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    PPIAL4C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002130 Cyclophilin-like_PPIase_dom
     IPR024936 Cyclophilin-type_PPIase
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry Q9Y536

    ProtoNet protein and cluster: Q9Y536

    1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PAL4A_HUMAN, Q9Y536
    Similarity: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily
    Similarity: Contains 1 PPIase cyclophilin-type domain


    PPIAL4C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAL4A_HUMAN, Q9Y536
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides (By similarity)
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IEA--
         
    PPIAL4C for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPIAL4C 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIAL4C


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPIAL4C

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for PPIAL4C (ENSP000003582244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP350ENSP000003565794STRING: ENSP00000356579
    ENSG00000168452ENSP000003984624STRING: ENSP00000398462
    FCGR1AENSP000003581654STRING: ENSP00000358165
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--

    PPIAL4C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPIAL4C (PAL4A)

    Search CenterWatch for drugs/clinical trials and news about PPIAL4C / PAL4A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPIAL4C gene: 
    NM_001135789.2  

    Unigene Cluster for PPIAL4C:

    Peptidylprolyl isomerase A (cyclophilin A)-like 4C
    Hs.717306
    Unigene Representative Sequence: NM_001135789
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369222(uc001esj.3)
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIAL4C

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPIAL4C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGTCTCA
    PPIAL4C Expression
    About this image


    See PPIAL4C Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.717306

    UniProtKB/Swiss-Prot: PAL4A_HUMAN, Q9Y536
    Tissue specificity: Highly expressed in brain, ovary and mammary gland. Moderately expressed in lung, salivary
    gland, kidney, skin, adipose tissue, intestine and spleen. Weakly expressed in skeletal muscle, liver and
    stomach. Expressed in pleiomorphic and undifferentiated liposarcomas, osteosarcomas and breast carcinomas

        SABiosciences Custom PCR Arrays for PPIAL4C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIAL4C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PPIAL4C gene from 5/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    (see all 5)
    Uncharacterized protein
    (see all 5)
    81(a)
    79(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    1(502617573-502622660)
    Un(38672129-38672623)
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 3)
    --


    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    12(25698-75398)
    1(139386530-139404977)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Peptidyl-prolyl cis-trans isomerase

    79(a)
    possible ortholog
    1 ↔ many
    3(107454117-107504389)
    GL343238.1(667038-675712)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50716
    Nup3586
    Nucleoporin 358
    5(a)
    1(a)
    possible ortholog
    possible ortholog
    3R(21444136-21446401)
    3R(21075316-21084394)
    worm
    (Caenorhabditis elegans)
    Secernentea T22F3.126
    Y17G9B.46
    (see all 3)
    Protein Y17G9B.4
    (see all 3)
    35(a)
    18(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    V(3589029-3592199)
    IV(4752094-4753230)


    ENSEMBL Gene Tree for PPIAL4C (if available)
    TreeFam Gene Tree for PPIAL4C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPIAL4C gene
    PPIAL4A1 2  PPIAL4B1 2  PPIAL4E  PPIAL4F  PPIAL4D1 2  PPIAL4G1 2  PPIE2  RANBP22  
    RGPD62  PPIF2  PPIA2  RGPD22  RGPD42  RGPD32  RGPD12  RGPD52  
    RGPD82  
    18/20 SIMAP similar genes for PPIAL4C using alignment to 1 protein entry:     PAL4A_HUMAN(see all similar genes):
    PPIAL4D    PPIAL4G    PPIA    LOC402252    PPIF    RANBP2
    PPIE    PPIC    PPIB    PPID    PPIL1    PPIH
    CWC27    DKFZp686G0426    PPIL6    NKTR    PPIG    PPIL3

    PPIAL4C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    7 SNPs in PPIAL4C are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs792278951,2
    C--149552565(+) GGCGTA/GGTGGT 1 -- us2k10--------
    rs1850156251,2
    --149552772(+) GAAATA/TAATGA 1 -- us2k10--------
    rs1386133191,2
    --149552999(+) AAAGGA/CCAAAC 1 -- us2k10--------
    rs1895438431,2
    --149553673(+) ATCTTG/TGTGCT 1 -- ut310--------
    rs3690218031,2
    ----149552717(+) AAAAAA/GAAGAA 1 -- us2k10--------
    rs2006837301,2
    ----149553054(+) CCATCA/GCTGTG 1 -- ut510--------
    rs3749663921,2
    ----149552690(+) AGCAAA/GACTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPIAL4C (149553003 - 149553787 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/37 variations for PPIAL4C (see all 37):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2658545CNV Deletion23128226
    dgv20n16CNV Deletion17901297
    dgv19n16CNV Insertion17901297
    esv999046CNV Loss20482838
    dgv7e55CNV Loss17911159
    nsv872204CNV Loss21882294
    dgv384n71CNV Loss21882294
    dgv383n71CNV Loss21882294
    nsv428212CNV Gain18775914
    nsv470736CNV Gain18288195

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for PPIAL4C:    About MalaCards
    liposarcoma    osteosarcoma


    PPIAL4C for disorders           About GeneDecksing


    Export disorders for PPIAL4C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPIAL4C gene integrated from 9 sources:
    (articles sorted by number of sources associating them with PPIAL4C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    2. Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21. (PubMed id 11948409)2 Meza-Zepeda L.A.... Myklebost O. (2002)
    3. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 653598 HGNC: 33995 Ensembl:ENSG00000198161 euGenes: HUgn653598 ECgene: PPIAL4C
    H-InvDB: PPIAL4C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPIAL4C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPIAL4C gene:
    Search GeneIP for patents involving PPIAL4C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
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     Regulatory tfbs in PPIAL4C promoter
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for PPIAL4C
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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