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PPIAL4B Gene

protein-coding   GIFtS: 32
GCID: GC01M144360          (predicted)

Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4B1 2     Peptidyl-Prolyl Cis-Trans Isomerase A-Like 4A/B/C2
Chromosome 1-Amplified Sequence 22 3     Peptidylprolyl Cis-Trans Isomerase A-Like 4A/B/C2
Cyclophilin Homolog Overexpressed In Liver Cancer2 3     COAS23
COAS-22 3     PPIase A-Like 4A3
EC 5.2.1.83 8     

External Ids:    HGNC: 339941   Entrez Gene: 6535052   Ensembl: ENSG000002558547   UniProtKB: Q9Y5363   

Export aliases for PPIAL4B gene to outside databases

Previous GC identifer: GC01M143073


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PPIAL4B Gene:
PPIAL4B (peptidylprolyl isomerase A (cyclophilin A)-like 4B) is a protein-coding gene. Diseases associated with PPIAL4B include liposarcoma, and osteosarcoma. An important paralog of this gene is PPIE.

UniProtKB/Swiss-Prot: PAL4A_HUMAN, Q9Y536
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPIAL4B gene promoter:
         NF-1/L   NF-1   Pbx1a   Nkx2-5   CUTL1   PPAR-alpha   S8   POU2F1   POU2F1a   ZIC2/Zic2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PPIAL4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPIAL4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1   Ensembl cytogenetic band:  1q21.1   HGNC cytogenetic band: 1q21.1

PPIAL4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIAL4B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M144360:  view genomic region     (about GC identifiers)

Start:
144,363,462 bp from pter      End:
144,364,246 bp from pter
Size:
785 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PAL4A_HUMAN, Q9Y536 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C  
Size: 164 amino acids; 18182 Da
Miscellaneous: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene
duplication, on chromosome 1

Explore the universe of human proteins at neXtProt for PPIAL4B: NX_Q9Y536

Explore proteomics data for PPIAL4B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPIAL4B (Q9Y536) (see all 9)
     GILSMAN  PKTAENF  LSMANAG  SIYGEKF 


    See PPIAL4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001137355.1  
    ENSEMBL proteins: 
     ENSP00000443989  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002130 Cyclophilin-type_PPIase_dom
     IPR024936 Cyclophilin-type_PPIase
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry Q9Y536

    ProtoNet protein and cluster: Q9Y536

    1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PAL4A_HUMAN, Q9Y536
    Similarity: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily
    Similarity: Contains 1 PPIase cyclophilin-type domain


    PPIAL4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAL4A_HUMAN, Q9Y536
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides (By similarity)
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity ----
         
    PPIAL4B for ontologies           About GeneDecksing


    Animal Models:
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    hsa-mir-1260b (MIRT052761)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAL4A_HUMAN, Q9Y536: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----

    PPIAL4B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPIAL4B
    Interactions:

        Search GeneGlobe Interaction Network for PPIAL4B

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding ----

    PPIAL4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPIAL4B (PAL4A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPIAL4B gene: 
    NM_001143883.2  

    Unigene Cluster for PPIAL4B:

    Peptidylprolyl isomerase A (cyclophilin A)-like 4B
    Hs.631792
    Unigene Representative Sequence: NM_001143883
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000540273(uc001ekw.3)
    miRNA
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      Search QuantiTect SYBR Green Assays in human, mouse, rat PPIAL4B
      QuantiFast Probe-based Assays in human, mouse, rat PPIAL4B

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPIAL4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PPIAL4B Expression
    About this image

    PPIAL4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPIAL4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631792

    UniProtKB/Swiss-Prot: PAL4A_HUMAN, Q9Y536
    Tissue specificity: Highly expressed in brain, ovary and mammary gland. Moderately expressed in lung, salivary
    gland, kidney, skin, adipose tissue, intestine and spleen. Weakly expressed in skeletal muscle, liver and
    stomach. Expressed in pleiomorphic and undifferentiated liposarcomas, osteosarcomas and breast carcinomas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIAL4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PPIAL4B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PPIA6
    peptidyl-prolyl cis-trans isomerase A
    80(a)
    1 → many
    22(4060940-4061857)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    79(a)
    1 → many
    GL343238.1(667038-675712)
    zebrafish
    (Danio rerio)
    Actinopterygii PPIA6
    peptidylprolyl isomerase A (cyclophilin A)
    1(a)
    1 → many
    9(399379-423700) ENSDARG00000093125
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50716
    --
    6(a)
    1 → many
    3R(21444136-21446401)
    worm
    (Caenorhabditis elegans)
    Secernentea T22F3.126
    Y17G9B.46
    Protein Y17G9B.4 (Y17G9B.4) mRNA, complete cds
    42(a)
    20(a)
    many ↔ many
    many ↔ many
    V(3589029-3592199) WBGene00044705
    IV(4752094-4753230) WBGene00021201
            Species with no ortholog for PPIAL4B

    ENSEMBL Gene Tree for PPIAL4B (if available)
    TreeFam Gene Tree for PPIAL4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPIAL4B gene
    PPIAL4C1 2  PPIAL4F  PPIAL4E  PPIAL4D1 2  PPIAL4G1 2  PPIE2  RANBP22  RGPD62  
    PPIF2  PPIA2  PPIAL4A2  RGPD22  RGPD42  RGPD32  RGPD12  RGPD52  
    RGPD82  
    Selected SIMAP similar genes for PPIAL4B using alignment to 1 protein entry:     PAL4A_HUMAN(see all similar genes):
    PPIAL4D    PPIAL4G    PPIA    LOC402252    PPIF    RANBP2
    PPIE    PPIC    PPIB    PPID    PPIL1    PPIH
    CWC27    DKFZp686G0426    PPIL6    NKTR    PPIG    PPIL3

    PPIAL4B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPIAL4B (see all 13)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2013610041,2
    C--144365890(+) TCAGTC/GTTTGT 1 -- us2k10--------
    rs2021955641,2
    C--144365901(+) CTTTCC/TGAGTC 1 -- us2k10--------
    rs2004765721,2
    C--144365961(+) GTTTCA/GCTTTG 1 -- us2k10--------
    rs3693064071,2
    ----144364477(+) TCATTA/TATTTC 1 -- us2k10--------
    rs3775569261,2
    ----144364528(+) TTCTTC/TTTTTT 1 -- us2k10--------
    rs3732028631,2
    ----144364817(+) CAACAA/GTGTAG 1 -- us2k10--------
    rs3744628511,2
    ----144366238(+) AGTCCC/TTAATT 1 -- us2k10--------
    rs3733713211,2
    ----144364478(+) CATTAA/CTTTCT 1 -- us2k10--------
    rs2002411181,2
    ----144364195(+) CACAGC/TGATGG 1 -- ut510--------
    rs3758418901,2
    ----144364850(+) TTGACA/TGTTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPIAL4B (144363462 - 144364246 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PPIAL4B (see all 54):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658545CNV Deletion23128226
    dgv20n16CNV Deletion17901297
    esv2717607CNV Deletion23290073
    dgv19n16CNV Insertion17901297
    esv999046CNV Loss20482838
    dgv359n71CNV Loss21882294
    dgv7e55CNV Loss17911159
    nsv872204CNV Loss21882294
    dgv384n71CNV Loss21882294
    dgv360n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PPIAL4B
    DNA2.0 Custom Variant and Variant Library Synthesis for PPIAL4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for PPIAL4B:    
    About MalaCards
    liposarcoma    osteosarcoma


    PPIAL4B for disorders           About GeneDecksing


    Export disorders for PPIAL4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPIAL4B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PPIAL4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21. (PubMed id 11948409)1, 2 Meza-Zepeda L.A.... Myklebost O. (Oncogene 2002)
    3. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 653505 HGNC: 33994 Ensembl:ENSG00000255854 euGenes: HUgn653505 ECgene: PPIAL4B
    H-InvDB: PPIAL4B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPIAL4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPIAL4B gene:
    Search GeneIP for patents involving PPIAL4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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