PPIAL4A Gene
protein-coding GIFtS: 37
GCID: GC01M147954
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peptidylprolyl isomerase A (cyclophilin A)-like 4A(Previous name: peptidylprolyl isomerase A (cyclophilin A)-like 4 )
(Previous symbol: PPIAL4)
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Aliases
for PPIAL4A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4A1 2 | | Chromosome 1 Amplified Sequence 22 | | COAS21 2 3 | | Cyclophilin-LC (COAS2)2 | | PPIAL41 2 | | Peptidyl-Prolyl Cis-Trans Isomerase A-Like 4A/B/C2 | | Peptidylprolyl Isomerase A (Cyclophilin A)-Like 41 2 | | Peptidylprolyl Cis-Trans Isomerase A-Like 42 | | Chromosome 1-Amplified Sequence 22 3 | | Peptidylprolyl Cis-Trans Isomerase A-Like 4A2 | | Cyclophilin Homolog Overexpressed In Liver Cancer2 3 | | Peptidylprolyl Cis-Trans Isomerase A-Like 4B2 | | COAS-22 3 | | Peptidylprolyl Isomerase A-Like 4A2 | | PPIase A-Like 4A2 3 | | PPIase A-Like 4B2 | | EC 5.2.1.83 8 | | PPIase A-Like 4G2 |
Export aliases for PPIAL4A gene to outside databasesPrevious GC identifer: GC01M146419 |
Summaries
for PPIAL4A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PAL4A_HUMAN, Q9Y536Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidicpeptide bonds in oligopeptides (By similarity)
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Genomic Views
for PPIAL4A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167185.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PPIAL4A gene promoter:
Nkx3-1 NF-1/L NF-1 Pbx1a Nkx3-1 v1 Nkx2-5 CUTL1 PPAR-alpha S8 ZIC2/Zic2
Other transcription factors
Search SABiosciences Chromatin IP Primers for PPIAL4A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIAL4A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.2 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1q21.1PPIAL4A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M147954: view genomic region
(about GC identifiers)
Start:
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147,954,635 bp from pter |
End:
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147,955,419 bp from pter |
Size:
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785 bases |
Orientation:
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minus strand |
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Proteins
for PPIAL4A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PAL4A_HUMAN, Q9Y536 (See
protein sequence)Recommended Name: Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C Size: 164 amino acids; 18182 Da
Subcellular location: Cytoplasm (By similarity)
Miscellaneous: It is one of seven related genes or pseudogenes found in a cluster, thought to result from geneduplication, on chromosome 1Explore the universe of human proteins at neXtProt for PPIAL4A: NX_Q9Y536
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y536
4/9 DME Specific Peptides for PPIAL4A (Q9Y536) (see all 9)
PPIAL4A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_839944.1
ENSEMBL proteins: ENSP00000439146
Human Recombinant Protein Products for PPIAL4A:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005737 | cytoplasm |
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PPIAL4A for ontologies About GeneDecksing
PPIAL4A Antibody Products:
Assay Products for PPIAL4A: |
Protein
Domains /
Families
for PPIAL4A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PPIAL4A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y536ProtoNet protein and cluster: Q9Y536 1 Blocks protein family: IPB002130 Peptidyl-prolyl cis-trans isomerase
UniProtKB/Swiss-Prot: PAL4A_HUMAN, Q9Y536Similarity: Belongs to the cyclophilin-type PPIase family. PPIase A subfamilySimilarity: Contains 1 PPIase cyclophilin-type domain |
Function
for PPIAL4A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PAL4A_HUMAN, Q9Y536Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidicpeptide bonds in oligopeptides (By similarity)Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0) Enzyme Number (IUBMB): EC 5.2.1.81 2
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
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PPIAL4A for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIAL4A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIAL4A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PPIAL4A (NM_178230) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPIAL4A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIAL4A |
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Pathways & Interactions
for PPIAL4A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPIAL4A
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006457 | protein folding |
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PPIAL4A for ontologies About GeneDecksing
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Drugs & Compounds
for PPIAL4A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PPIAL4A
Search CenterWatch for drugs/clinical trials and news about PPIAL4A / PAL4A
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Transcripts
for PPIAL4A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PPIAL4A gene: NM_178230.1 Unigene Cluster for PPIAL4A: Peptidylprolyl isomerase A (cyclophilin A)-like 4A Hs.573713 Unigene Representative Sequence: NM_1782301 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000539781(uc001eqp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIAL4A
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIAL4A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PPIAL4A (NM_178230) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPIAL4A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIAL4A |
Additional cDNA sequence: AB084917.1 1 DOTS entry: DT.121460273 4 AceView cDNA sequences: AB084917 NM_178230 CR622951 AK123006
GeneLoc Exon Structure
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Expression
for PPIAL4A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PPIAL4A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCACTTTG
About this image
See PPIAL4A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPIAL4A
SOURCE GeneReport for Unigene cluster: Hs.573713
UniProtKB/Swiss-Prot: PAL4A_HUMAN, Q9Y536Tissue specificity: Highly expressed in brain, ovary and mammary gland. Moderately expressed in lung, salivary gland,kidney, skin, adipose tissue, intestine and spleen. Weakly expressed in skeletal muscle, liver and stomach. Expressedin pleiomorphic and undifferentiated liposarcomas, osteosarcomas and breast carcinomas
SABiosciences Custom PCR Arrays for PPIAL4A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPIAL4A
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat PPIAL4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIAL4A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIAL4A |
Orthologs
for PPIAL4A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for PPIAL4A gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for PPIAL4A (if available)
TreeFam Gene Tree for PPIAL4A (if available) |
Paralogs
for PPIAL4A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PPIAL4A gene
- PPIAL4C1 2 PPIAL4B1 2 PPIAL4E PPIAL4F PPIAL4D1 2 PPIAL4G1 2 PPIE2 PPIF2
- PPIA2
18/19 SIMAP similar genes for PPIAL4A using alignment to 1 protein entry: PAL4A_HUMAN(see all similar genes):PPIAL4G PPIA LOC402252 PPIF RANBP2 PPIE
PPIC PPIB PPID PPIL1 PPIH CWC27
DKFZp686G0426 PPIL6 NKTR PPIG PPIL3 PPWD1
PPIAL4A for paralogs About GeneDecksing
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Genomic Variants
for PPIAL4A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PPIAL4A (147954635 - 147955419 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 29 variations for PPIAL4A
15/29 CNVs (see all 29): 48119 8924 4248 69848 6785 48120 2326 48129 74703 84559 69964 30426 48118 8329 3310 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for PPIAL4A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PPIAL4A for disorders About GeneDecksing
7  diseases for PPIAL4A: About MalaCardsliver cancer liposarcoma breast carcinoma osteosarcoma
sarcoma carcinoma malaria
Export disorders for PPIAL4A gene to outside databases
|
Publications
for PPIAL4A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PPIAL4A gene integrated from 9 sources:
(articles sorted by number of sources associating them with PPIAL4A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21. (PubMed id 11948409)1, 2, 3 Meza-Zepeda L.A.... Myklebost O. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Amplification of chromosome 1 sequences in lipomatous tumors and other sarcomas. (PubMed id 14961574)1 Nilsson M....Mandahl N. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for PPIAL4A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing PPIAL4A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing PPIAL4A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PPIAL4A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PPIAL4A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for PPIAL4A gene:
Search GeneIP for patents involving PPIAL4A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PPIAL4A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PPIAL4A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPIAL4A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPIAL4A | | | OriGene Protein Over-expression Lysate for PPIAL4A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PPIAL4A | | OriGene 3'-UTR Clone for PPIAL4A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIAL4A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIAL4A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PPIAL4A | | OriGene Custom Protein Services for PPIAL4A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPIAL4A | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPIAL4A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIAL4A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIAL4A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIAL4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIAL4A |
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 | | | PPIAL4A Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for PPIAL4A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIAL4A |
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