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Aliases for PPIAL4A Gene

Aliases for PPIAL4A Gene

  • Peptidylprolyl Isomerase A Like 4A 2 3
  • Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4B 2 3
  • Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4A 3 5
  • Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4 2 3
  • Cyclophilin Homolog Overexpressed In Liver Cancer 3 4
  • Chromosome One-Amplified Sequence 2 3 4
  • EC 4 63
  • PPIAL4B 3 4
  • COAS-2 3 4
  • COAS2 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase A-Like 4A/B/C 3
  • Peptidylprolyl Cis-Trans Isomerase A-Like 4A 3
  • Peptidylprolyl Cis-Trans Isomerase A-Like 4B 3
  • Chromosome 1-Amplified Sequence 2 3
  • Cyclophilin-LC (COAS2) 3
  • PPIase A-Like 4B 3
  • PPIase A-Like 4G 3
  • PPIase A-Like 4A 4
  • PPIAL4 3

External Ids for PPIAL4A Gene

Previous HGNC Symbols for PPIAL4A Gene

  • PPIAL4

Previous GeneCards Identifiers for PPIAL4A Gene

  • GC01M146419
  • GC01M147954

Summaries for PPIAL4A Gene

GeneCards Summary for PPIAL4A Gene

PPIAL4A (Peptidylprolyl Isomerase A Like 4A) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIE.

UniProtKB/Swiss-Prot for PPIAL4A Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIAL4A Gene

Genomics for PPIAL4A Gene

Regulatory Elements for PPIAL4A Gene

Genomic Location for PPIAL4A Gene

120,889,746 bp from pter
120,890,530 bp from pter
785 bases
Plus strand

Genomic View for PPIAL4A Gene

Genes around PPIAL4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIAL4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIAL4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIAL4A Gene

Proteins for PPIAL4A Gene

  • Protein details for PPIAL4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A-like 4A
    Protein Accession:

    Protein attributes for PPIAL4A Gene

    164 amino acids
    Molecular mass:
    18182 Da
    Quaternary structure:
    No Data Available
    • It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.

neXtProt entry for PPIAL4A Gene

Proteomics data for PPIAL4A Gene at MOPED

Selected DME Specific Peptides for PPIAL4A Gene

Post-translational modifications for PPIAL4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPIAL4A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PPIAL4A Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
genes like me logo Genes that share domains with PPIAL4A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for PPIAL4A Gene

Function for PPIAL4A Gene

Molecular function for PPIAL4A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Enzyme Numbers (IUBMB) for PPIAL4A Gene

Phenotypes for PPIAL4A Gene

genes like me logo Genes that share phenotypes with PPIAL4A: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PPIAL4A Gene

Localization for PPIAL4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIAL4A Gene


Subcellular locations from

Jensen Localization Image for PPIAL4A Gene COMPARTMENTS Subcellular localization image for PPIAL4A gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PPIAL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPIAL4A: view

Pathways & Interactions for PPIAL4A Gene

SuperPathways for PPIAL4A Gene

No Data Available

Interacting Proteins for PPIAL4A Gene

Gene Ontology (GO) - Biological Process for PPIAL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
genes like me logo Genes that share ontologies with PPIAL4A: view

No data available for Pathways by source and SIGNOR curated interactions for PPIAL4A Gene

Drugs & Compounds for PPIAL4A Gene

No Compound Related Data Available

Transcripts for PPIAL4A Gene

mRNA/cDNA for PPIAL4A Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PPIAL4A Gene

No ASD Table

Relevant External Links for PPIAL4A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIAL4A Gene

mRNA expression in normal human tissues for PPIAL4A Gene

Protein differential expression in normal tissues from HIPED for PPIAL4A Gene

This gene is overexpressed in Skin (30.7), Serum (11.1), Brain (8.5), and Lung (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PPIAL4A Gene

mRNA Expression by UniProt/SwissProt for PPIAL4A Gene

Tissue specificity: Highly expressed in brain, ovary and mammary gland. Moderately expressed in lung, salivary gland, kidney, skin, adipose tissue, intestine and spleen. Weakly expressed in skeletal muscle, liver and stomach. Expressed in pleiomorphic and undifferentiated liposarcomas, osteosarcomas and breast carcinomas.
genes like me logo Genes that share expression patterns with PPIAL4A: view

Protein tissue co-expression partners for PPIAL4A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPIAL4A Gene

Orthologs for PPIAL4A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PPIAL4A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100612700 35
  • 97.96 (n)
  • 96.32 (a)
Species with no ortholog for PPIAL4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PPIAL4A Gene

Gene Tree for PPIAL4A (if available)
Gene Tree for PPIAL4A (if available)

Paralogs for PPIAL4A Gene

(20) SIMAP similar genes for PPIAL4A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPIAL4A: view

Variants for PPIAL4A Gene

Structural Variations from Database of Genomic Variants (DGV) for PPIAL4A Gene

Variant ID Type Subtype PubMed ID
nsv428212 CNV Gain 18775914
nsv872203 CNV Gain 21882294
dgv102e1 CNV Complex 17122850
dgv103e1 CNV Complex 17122850
dgv104e1 CNV Complex 17122850
esv25174 CNV Gain 19812545
nsv872204 CNV Loss 21882294
nsv831281 CNV Gain 17160897
nsv872205 CNV Gain 21882294
esv2512286 CNV Gain 19546169
nsv7181 OTHER Inversion 18451855
dgv116e1 CNV Complex 17122850
dgv117e1 CNV Complex 17122850
nsv510984 OTHER Inversion 20534489
esv2750803 CNV Gain 17911159
nsv428235 CNV Gain 18775914
dgv118e1 CNV Complex 17122850
dgv119e1 CNV Complex 17122850
dgv120e1 CNV Complex 17122850
dgv7e55 CNV Loss 17911159
esv2750807 CNV Gain 17911159
dgv357n71 CNV Gain 21882294
esv2717607 CNV Deletion 23290073
dgv358n71 CNV Gain 21882294
esv23584 CNV Gain 19812545
nsv8225 CNV Gain 18304495
nsv872281 CNV Gain+Loss 21882294
dgv121e1 CNV Complex 17122850
dgv359n71 CNV Loss 21882294
nsv872284 CNV Gain 21882294
dgv360n71 CNV Loss 21882294
nsv872286 CNV Loss 21882294
dgv122e1 CNV Complex 17122850
esv33539 CNV Gain+Loss 17666407
dgv123e1 CNV Complex 17122850
dgv125e1 CNV Complex 17122850
dgv126e1 CNV Complex 17122850
nsv872306 CNV Gain 21882294
nsv8302 CNV Gain 18304495
nsv470736 CNV Gain 18288195
esv2750809 CNV Gain 17911159
nsv872378 CNV Gain 21882294
nsv872384 CNV Gain 21882294
dgv19n16 CNV Insertion 17901297
esv2658545 CNV Deletion 23128226
dgv20n16 CNV Deletion 17901297
dgv380n71 CNV Gain+Loss 21882294
dgv381n71 CNV Gain 21882294
nsv872398 CNV Gain 21882294
esv21909 CNV Gain 19812545
dgv383n71 CNV Loss 21882294
dgv384n71 CNV Loss 21882294
esv999046 CNV Loss 20482838
nsv872411 CNV Gain 21882294

Variation tolerance for PPIAL4A Gene

Gene Damage Index Score: 5.35; 70.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIAL4A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PPIAL4A Gene

Disorders for PPIAL4A Gene

Relevant External Links for PPIAL4A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PPIAL4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIAL4A Gene

Publications for PPIAL4A Gene

  1. Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21. (PMID: 11948409) Meza-Zepeda L.A. … Myklebost O. (Oncogene 2002) 2 3 4 67
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
  5. Amplification of chromosome 1 sequences in lipomatous tumors and other sarcomas. (PMID: 14961574) Nilsson M. … Mandahl N. (Int. J. Cancer 2004) 3

Products for PPIAL4A Gene

Sources for PPIAL4A Gene

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