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Aliases for PPIAL4A Gene

Aliases for PPIAL4A Gene

  • Peptidylprolyl Isomerase A Like 4A 2 3 5
  • Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4B 2 3
  • Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4 2 3
  • Cyclophilin Homolog Overexpressed In Liver Cancer 3 4
  • Chromosome One-Amplified Sequence 2 3 4
  • EC 5.2.1.8 4 61
  • PPIAL4B 3 4
  • COAS-2 3 4
  • COAS2 3 4
  • Peptidylprolyl Isomerase A (Cyclophilin A)-Like 4A 3
  • Peptidyl-Prolyl Cis-Trans Isomerase A-Like 4A/B/C 3
  • Peptidyl-Prolyl Cis-Trans Isomerase A-Like 4A 3
  • Peptidylprolyl Cis-Trans Isomerase A-Like 4A 3
  • Peptidylprolyl Cis-Trans Isomerase A-Like 4B 3
  • Chromosome 1-Amplified Sequence 2 3
  • Cyclophilin-LC (COAS2) 3
  • PPIase A-Like 4B 3
  • PPIase A-Like 4G 3
  • PPIase A-Like 4A 4
  • PPIAL4 3

External Ids for PPIAL4A Gene

Previous HGNC Symbols for PPIAL4A Gene

  • PPIAL4
  • PPIAL4B

Previous GeneCards Identifiers for PPIAL4A Gene

  • GC01M146419
  • GC01M147954

Summaries for PPIAL4A Gene

GeneCards Summary for PPIAL4A Gene

PPIAL4A (Peptidylprolyl Isomerase A Like 4A) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIAL4C.

UniProtKB/Swiss-Prot for PPIAL4A Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIAL4A Gene

Genomics for PPIAL4A Gene

Regulatory Elements for PPIAL4A Gene

Enhancers for PPIAL4A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F120890 0.2 Ensembl 0.8 +1.7 1655 2.4 PPIAL4A LINC00623
GH01F120893 0.2 Ensembl 0.8 +3.4 3355 0.2 PPIAL4A LINC00623
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PPIAL4A on UCSC Golden Path with GeneCards custom track

Genomic Location for PPIAL4A Gene

Chromosome:
1
Start:
120,889,746 bp from pter
End:
120,890,530 bp from pter
Size:
785 bases
Orientation:
Plus strand

Genomic View for PPIAL4A Gene

Genes around PPIAL4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIAL4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIAL4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIAL4A Gene

Proteins for PPIAL4A Gene

  • Protein details for PPIAL4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y536-PAL4A_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A-like 4A
    Protein Accession:
    Q9Y536

    Protein attributes for PPIAL4A Gene

    Size:
    164 amino acids
    Molecular mass:
    18182 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.

neXtProt entry for PPIAL4A Gene

Selected DME Specific Peptides for PPIAL4A Gene

Q9Y536:
  • FMCQGGDF
  • LSMANAG
  • TNGSQFF
  • TAENFRAL
  • SIYGEKF
  • GPNTNGSQ
  • PKTAENF
  • GILSMAN
  • KTEWLDG

Post-translational modifications for PPIAL4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPIAL4A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PPIAL4A Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y536

UniProtKB/Swiss-Prot:

PAL4A_HUMAN :
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
genes like me logo Genes that share domains with PPIAL4A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for PPIAL4A Gene

Function for PPIAL4A Gene

Molecular function for PPIAL4A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

Enzyme Numbers (IUBMB) for PPIAL4A Gene

Gene Ontology (GO) - Molecular Function for PPIAL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PPIAL4A: view

Phenotypes for PPIAL4A Gene

genes like me logo Genes that share phenotypes with PPIAL4A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PPIAL4A Gene

Localization for PPIAL4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIAL4A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIAL4A Gene COMPARTMENTS Subcellular localization image for PPIAL4A gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PPIAL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with PPIAL4A: view

Pathways & Interactions for PPIAL4A Gene

SuperPathways for PPIAL4A Gene

No Data Available

Interacting Proteins for PPIAL4A Gene

Selected Interacting proteins: Q9Y536-PAL4A_HUMAN for PPIAL4A Gene via IID

Gene Ontology (GO) - Biological Process for PPIAL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with PPIAL4A: view

No data available for Pathways by source and SIGNOR curated interactions for PPIAL4A Gene

Transcripts for PPIAL4A Gene

mRNA/cDNA for PPIAL4A Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIAL4A Gene

No ASD Table

Relevant External Links for PPIAL4A Gene

GeneLoc Exon Structure for
PPIAL4A
ECgene alternative splicing isoforms for
PPIAL4A

Expression for PPIAL4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPIAL4A Gene

Protein differential expression in normal tissues from HIPED for PPIAL4A Gene

This gene is overexpressed in Skin (30.7), Serum (11.1), Brain (8.5), and Lung (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPIAL4A Gene



Protein tissue co-expression partners for PPIAL4A Gene

NURSA nuclear receptor signaling pathways regulating expression of PPIAL4A Gene:

PPIAL4A

mRNA Expression by UniProt/SwissProt for PPIAL4A Gene:

Q9Y536-PAL4A_HUMAN
Tissue specificity: Highly expressed in brain, ovary and mammary gland. Moderately expressed in lung, salivary gland, kidney, skin, adipose tissue, intestine and spleen. Weakly expressed in skeletal muscle, liver and stomach. Expressed in pleiomorphic and undifferentiated liposarcomas, osteosarcomas and breast carcinomas.
genes like me logo Genes that share expression patterns with PPIAL4A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPIAL4A Gene

Orthologs for PPIAL4A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PPIAL4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100612700 34
  • 97.96 (n)
Species where no ortholog for PPIAL4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PPIAL4A Gene

ENSEMBL:
Gene Tree for PPIAL4A (if available)
TreeFam:
Gene Tree for PPIAL4A (if available)

Paralogs for PPIAL4A Gene

(20) SIMAP similar genes for PPIAL4A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPIAL4A: view

Variants for PPIAL4A Gene

Sequence variations from dbSNP and Humsavar for PPIAL4A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2257913 -- 120,890,629(-) accaa(C/T)gtatt downstream-variant-500B
rs2260114 -- 120,889,119(+) CAAAC(A/T)GTCAA upstream-variant-2KB
rs2814238 -- 120,889,742(+) aaagg(A/C)caaac upstream-variant-2KB
rs2814239 -- 120,889,797(+) CCATC(A/G)CTGTG utr-variant-5-prime
rs2814240 -- 120,889,919(+) ACAGC(A/G)GAAAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PPIAL4A Gene

Variant ID Type Subtype PubMed ID
dgv96e212 CNV loss 25503493
dgv97e212 CNV loss 25503493
nsv1078901 CNV deletion 25765185
nsv524681 CNV gain 19592680
nsv547684 CNV loss 21841781

Variation tolerance for PPIAL4A Gene

Gene Damage Index Score: 5.35; 70.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIAL4A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPIAL4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIAL4A Gene

Disorders for PPIAL4A Gene

Relevant External Links for PPIAL4A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPIAL4A

No disorders were found for PPIAL4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPIAL4A Gene

Publications for PPIAL4A Gene

  1. Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21. (PMID: 11948409) Meza-Zepeda L.A. … Myklebost O. (Oncogene 2002) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64
  5. Amplification of chromosome 1 sequences in lipomatous tumors and other sarcomas. (PMID: 14961574) Nilsson M. … Mandahl N. (Int. J. Cancer 2004) 3 64

Products for PPIAL4A Gene

Sources for PPIAL4A Gene

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