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PPIA Gene

protein-coding   GIFtS: 69
GCID: GC07P044841

Peptidylprolyl Isomerase A (Cyclophilin A)

  See PPIA-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peptidylprolyl Isomerase A (Cyclophilin A)1 2     HEL-S-69p2
Cyclosporin A-Binding Protein2 3     cyclophilin2
Rotamase A2 3     Epididymis Secretory Sperm Binding Protein Li 69p2
CYPA2 3     Peptidyl-Prolyl Cis-Trans Isomerase A2
PPIase A2 3     T Cell Cyclophilin2
EC 5.2.1.83 8     Cyclophilin A3
CYPH2     

External Ids:    HGNC: 92531   Entrez Gene: 54782   Ensembl: ENSG000001962627   OMIM: 1238405   UniProtKB: P629373   

Export aliases for PPIA gene to outside databases

Previous GC identifers: GC07P044482 GC07P044543 GC07P044577 GC07P044609 GC07P044803


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPIA Gene:
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the
cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins.
The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated
immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid
protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes
that map to different chromosomes have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPIA Gene:
PPIA (peptidylprolyl isomerase A (cyclophilin A)) is a protein-coding gene. Diseases associated with PPIA include in situ carcinoma. GO annotations related to this gene include unfolded protein binding and peptide binding. An important paralog of this gene is PPIE.

UniProtKB/Swiss-Prot: PPIA_HUMAN, P62937
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides

Gene Wiki entry for PPIA (Peptidylprolyl isomerase A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPIA gene promoter:
         SRF   AML1a   SRF (504 AA)   Nkx3-1 v1   PPAR-alpha   MZF-1   ZIC2/Zic2   ATF   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPIA promoter sequence
   Search Chromatin IP Primers for PPIA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPIA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p13

PPIA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPIA gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P044841:  view genomic region     (about GC identifiers)

Start:
44,836,241 bp from pter      End:
44,864,163 bp from pter
Size:
27,923 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 44,875,748-44,882,224     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PPIA_HUMAN, P62937 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase A  
Size: 165 amino acids; 18012 Da
Subunit: Interacts with HIV-1 Capsid protein
Selected PDB 3D structures from and Proteopedia for PPIA (see all 63):
1AK4 (3D)        1AWQ (3D)        1AWR (3D)        1AWS (3D)        1AWT (3D)        1AWU (3D)    
Secondary accessions: A8K220 P05092 Q3KQW3 Q6IBU5 Q96IX3 Q9BRU4 Q9BTY9 Q9UC61

Explore the universe of human proteins at neXtProt for PPIA: NX_P62937

Explore proteomics data for PPIA at MOPED

Post-translational modifications: 

  • Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than
    trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine
    by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition1
  • Ubiquitination2 at Lys31, Lys44, Lys49, Lys76, Lys82, Lys91, Lys118, Lys125, Lys131, Lys133,
                                 Lys155
  • Glycosylation2 at Asn108
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PPIA (P62937) (see all 16)
     GILSMAN  GGKSIYG  SIYGEKF  LSMANAG 


    See PPIA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066953.1  
    ENSEMBL proteins: 
     ENSP00000405975   ENSP00000419425   ENSP00000427976   ENSP00000430817   ENSP00000429251  
     ENSP00000394670  
    Reactome Protein details: P62937

    PPIA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PPIA (Cyclophilin A)
    Enzo Life Sciences proteins for PPIA
    OriGene Purified Protein for PPIA
    OriGene Protein Over-expression Lysate for PPIA
    OriGene MassSpec for PPIA
    OriGene Custom Protein Services for PPIA
    GenScript Custom Purified and Recombinant Proteins Services for PPIA
    Novus Biologicals PPIA Proteins
    Novus Biologicals PPIA Lysates
    Sino Biological Recombinant Protein for PPIA
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PPIA
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PPIA 

    PPIA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PPIA
    R&D Systems Antibodies for PPIA (Cyclophilin A)
    Cell Signaling Technology (CST) Antibodies for PPIA 
    OriGene Antibodies for PPIA
    OriGene Custom Antibody Services for PPIA
    Novus Biologicals PPIA Antibodies
    Abcam antibodies for PPIA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PPIA
    LSBio Antibodies in human, mouse, rat for PPIA

    PPIA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PPIA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPIA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PPIA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002130 Cyclophilin-type_PPIase_dom
     IPR024936 Cyclophilin-type_PPIase
     IPR020892 Cyclophilin-type_PPIase_CS

    Graphical View of Domain Structure for InterPro Entry P62937

    ProtoNet protein and cluster: P62937

    1 Blocks protein domain: IPB002130 Peptidyl-prolyl cis-trans isomerase

    UniProtKB/Swiss-Prot: PPIA_HUMAN, P62937
    Similarity: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily
    Similarity: Contains 1 PPIase cyclophilin-type domain


    Find genes that share domains with PPIA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPIA_HUMAN, P62937
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase

         Genatlas biochemistry entry for PPIA:
    cyclophilin A,major intracellular receptor for the immunosuppressive agent cyclosporine A,with intrinsic
    peptidyl-prolyl cis-trans isomerase activity

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IDA14993672
    GO:0005515protein binding IPI12730686
    GO:0042277peptide binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0046790virion binding NAS11250896
         
    Find genes that share ontologies with PPIA           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppia):
     cardiovascular system  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  vision/eye 

    Find genes that share phenotypes with PPIA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ppiatm1Lubn for PPIA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPIA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPIA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPIA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPIA

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPIA:
    hsa-mir-18a-3p (MIRT040751), hsa-mir-455-3p (MIRT037899), hsa-mir-26a-5p (MIRT050185), hsa-mir-106b-5p (MIRT044321), hsa-mir-17-3p (MIRT050789), hsa-mir-197-3p (MIRT048054), hsa-mir-324-5p (MIRT043038), hsa-mir-31-3p (MIRT038938), hsa-mir-320b (MIRT036191), hsa-mir-18a-5p (MIRT050690), hsa-mir-760 (MIRT036733), hsa-mir-218-5p (MIRT046998), hsa-mir-1226-3p (MIRT036511), hsa-mir-3200-3p (MIRT052825), hsa-mir-30c-1-3p (MIRT038540), hsa-mir-342-5p (MIRT038227), hsa-mir-423-5p (MIRT038051), hsa-mir-1307-3p (MIRT035823), hsa-mir-1 (MIRT023905), hsa-mir-320a (MIRT044403)

    Block miRNA regulation of human, mouse, rat PPIA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPIA (see all 15):
    hsa-miR-4324 hsa-miR-577 hsa-miR-610 hsa-miR-186* hsa-miR-509-5p hsa-miR-618 hsa-miR-548v hsa-miR-876-3p
    SwitchGear 3'UTR luciferase reporter plasmidPPIA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPIA
    Predesigned siRNA for gene silencing in human, mouse, rat PPIA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPIA

    Clone
    Products:
         
    OriGene clones in human, mouse for PPIA (see all 7)
    OriGene ORF clones in mouse, rat for PPIA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPIA (NM_021130)
    Sino Biological Human cDNA Clone for PPIA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIA

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PPIA 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIA

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-11103) for PPIA 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPIA_HUMAN, P62937: Cytoplasm. Secreted. Note=Secretion occurs in response to oxidative stress in vascular
    smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and
    mediates ERK1/2 activation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular5
    nucleus5
    plasma membrane2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005634nucleus IDA16780588
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with PPIA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPIA About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1HIV Life Cycle
    HIV Life Cycle0.91
    Binding and entry of HIV virion0.00
    Late Phase of HIV Life Cycle0.91
    APOBEC3G mediated resistance to HIV-1 infection0.00
    HIV Infection0.62
    Assembly Of The HIV Virion0.00
    Host Interactions of HIV factors0.60
    Integration of provirus0.00
    2Plus-strand DNA synthesis
    Plus-strand DNA synthesis
    Uncoating of the HIV Virion0.00
    Minus-strand DNA synthesis0.00
    Reverse Transcription of HIV RNA0.00
    3Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    4Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    5Budding and maturation of HIV virion
    Budding and maturation of HIV virion0.64


    Find genes that share SuperPaths with PPIA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PPIA
        Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for PPIA
        Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)

    1 BioSystems Pathway for PPIA
        Prolactin Signaling Pathway


    Selected Reactome Pathways for PPIA (see all 11)
        Plus-strand DNA synthesis
    Budding and maturation of HIV virion
    Minus-strand DNA synthesis
    Early Phase of HIV Life Cycle
    Binding and entry of HIV virion

    1 PharmGKB Pathway for PPIA
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPIA: 
              HIV Host Response in human mouse rat
              Necrosis in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPIA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPIA (P629371, 2, 3 ENSP000004194254) via UniProtKB, MINT, STRING, and/or I2D (see all 166)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPRNQ168491, 3, ENSP000002957184EBI-437708,EBI-728153 I2D: score=3 STRING: ENSP00000295718
    PCNAP120042, 3MINT-7995260 I2D: score=2 
    SUPT5HO002671, 3EBI-437708,EBI-710464 I2D: score=2 
    ENSG00000235068Q018603, ENSP000004050414I2D: score=1 STRING: ENSP00000405041
    ENSG00000206454Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization IDA14993672
    GO:0002576platelet degranulation TAS--
    GO:0006278RNA-dependent DNA replication TAS--
    GO:0006457protein folding TAS2179953
    GO:0007596blood coagulation TAS--

    Find genes that share ontologies with PPIA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPIA

    1 HMDB Compound for PPIA    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Proline(-)-(S)-Proline (see all 16)147-85-3--

    5 DrugBank Compounds for PPIA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CyclosporineCiclosporin (see all 4)59865-13-3target--17609268 20368803 17461417 20637127 16849427 16641261
    (3r)-1-Acetyl-3-Methylpiperidine-- --target--17139284 17016423 10592235
    (3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl--- --target--17139284 17016423 10592235
    L-Proline(-)-2-Pyrrolidinecarboxylic acid (see all 6)147-85-3targetbinder17139284 11752352 17016423
    Ethyl Oxo(Piperidin-1-Yl)Acetate-- 53074-96-7target--10592235

    10 Novoseek inferred chemical compound relationships for PPIA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclosporin a 76.1 72 17141764 (3), 7476967 (2), 10208939 (2), 7866747 (2) (see all 41)
    glyceraldehyde 3-phosphate 56.1 8 18191039 (1), 12682639 (1), 14578405 (1), 11962599 (1) (see all 5)
    heparan sulfate 34 1 17588944 (1)
    tacrolimus 30.3 2 7476967 (1), 1464374 (1)
    proline 7.47 2 9032343 (2)
    urea 2.08 1 17141764 (1)
    atp 0 3 14654946 (1), 14578405 (1)
    thymidine 0 1 16604531 (1)
    calcium 0 1 18567920 (1)
    hydrogen 0 2 15772070 (1), 7866747 (1)



    Find genes that share compounds with PPIA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPIA gene (3 alternative transcripts): 
    NM_021130.3  NM_203430.1  NM_203431.1  

    Unigene Cluster for PPIA:

    Peptidylprolyl isomerase A (cyclophilin A)
    Hs.356331  [show with all ESTs]
    Unigene Representative Sequence: NM_021130
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481437 ENST00000451562 ENST00000468812(uc003tlw.3 uc003tlx.3 uc010kyl.3)
    ENST00000489459 ENST00000355968 ENST00000479021 ENST00000415933 ENST00000494484
    ENST00000480603
    miRNA
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    Block miRNA regulation of human, mouse, rat PPIA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPIA (see all 15):
    hsa-miR-4324 hsa-miR-577 hsa-miR-610 hsa-miR-186* hsa-miR-509-5p hsa-miR-618 hsa-miR-548v hsa-miR-876-3p
    SwitchGear 3'UTR luciferase reporter plasmidPPIA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PPIA
    Clone
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    OriGene ORF clones in mouse, rat for PPIA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPIA (NM_021130)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPIA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIA
    Primer
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    OriGene qPCR primer pairs and template standards for PPIA
    OriGene qSTAR qPCR primer pairs in human, mouse for PPIA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPIA
      QuantiTect SYBR Green Assays in human, mouse, rat PPIA
      QuantiFast Probe-based Assays in human, mouse, rat PPIA
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-11103) for PPIA 

    Additional mRNA sequence: 

    AB451307.1 AB451438.1 AK026569.1 AK130101.1 AK290085.1 AK290851.1 AK293003.1 AK297340.1 
    AK316564.1 BC000689.2 BC003026.1 BC005320.1 BC005982.1 BC007104.1 BC013915.1 BC018843.2 
    BC073992.1 BC093076.1 BC106030.1 BC137057.1 BC137058.1 CR456707.1 Y00052.1 

    Selected DOTS entries (see all 120):

    DT.91782512  DT.95376662  DT.220845  DT.91782568  DT.91782539  DT.100846396  DT.121123710  DT.91782522 
    DT.102845567  DT.100866435  DT.95377532  DT.100713075  DT.100713079  DT.100060454  DT.121123866  DT.97870652 
    DT.95377102  DT.100713073  DT.100060460  DT.100018218  DT.100713093  DT.100713057  DT.121123721  DT.100713091 

    Selected AceView cDNA sequences (see all 3717):

    BM986943 BE907281 BM464469 AA301600 BM508097 BM905058 BM916248 CN480152 
    BM453695 CB114293 BE263553 BQ424774 CA748961 BE795983 BE792328 BM987581 
    BU156247 BU857225 BU189032 BU631485 BM665795 BQ943740 BE407444 BQ027320 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PPIA    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
    SP1:                    -                                 
    SP2:                    -                                 
    SP3:                    -                 -               
    SP4:                                      -               


    ECgene alternative splicing isoforms for PPIA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPIA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTAGCTGGA
    PPIA Expression
    About this image

    PPIA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPIA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.356331
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPIA: 
              HIV Host Response in human mouse rat
              Necrosis in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPIA gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppia1 , 5 peptidylprolyl isomerase A1, 5 92.48(n)1
    96.34(a)1
      11 (3.97 cM)5
    2683731  NM_008907.11  NP_032933.11 
     64154435 
    chicken
    (Gallus gallus)
    Aves PPIA1 peptidylprolyl isomerase A (cyclophilin A) 81.71(n)
    90.85(a)
      776282  NM_001166326.1  NP_001159798.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    90(a)
    1 → many
    GL343238.1(667038-675712)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986302 hypothetical protein LOC398630 76.15(n)    BC054186.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd61c062 Transcribed sequence with moderate similarity to protein more 77.68(n)    57059550 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cyp13 protein folding cyclin-dependent
    protein kinase, more
    74(a)
    (best of 2)
      14B12   --
    worm
    (Caenorhabditis elegans)
    Secernentea cyp-33
    cyn-11
    Peptidyl-prolyl cis-trans isomerases3
    cyn-11
    67(a)
    (best of 3)3
    65.43(n)1
    72.84(a)1
      V(15192351-15193440)3
    1799361  NM_074160.51  NP_506561.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CPR31 CPR3 59.33(n)
    65.41(a)
      854897   NP_013633.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ROC21 ROC2 66.46(n)
    73.33(a)
      824773  NM_115465.4  NP_191166.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g05714001 Os09g0571400 66.05(n)
    72.84(a)
      4347920  NM_001070528.1  NP_001063993.1 


    ENSEMBL Gene Tree for PPIA (if available)
    TreeFam Gene Tree for PPIA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPIA gene
    PPIE2  PPIAL4C2  RANBP22  RGPD62  PPIF2  PPIAL4D2  PPIAL4A2  RGPD22  
    RGPD42  PPIAL4G2  RGPD32  RGPD12  PPIAL4B2  RGPD52  RGPD82  
    Selected SIMAP similar genes for PPIA using alignment to 5 protein entries:     PPIA_HUMAN (see all proteins) (see all similar genes):
    LOC388817    PPIAL4A    PPIAL4B    PPIAL4C    PPIAL4G    PPIAL4D
    PPIF    RANBP2    PPIE    LOC402252    PPIB    PPIC
    PPID    PPIH    PPIL1    CWC27    PPIL3    PPIL2

    Find genes that share paralogs with PPIA           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for PPIA (see all 99)
    PGOHUM00000238365 PGOHUM00000238396 PGOHUM00000238539 PGOHUM00000238620 PGOHUM00000238630


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPIA (see all 244)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1926033331,2
    --44809778(+) TTTTGC/TCTCAC 1 -- us2k10--------
    rs178600381,2
    C,F--44810026(+) GGGAGG/TCTAAG 1 -- us2k15Minor allele frequency- T:0.04NS NA EA 280
    rs109517721,2
    C,F,A,H--44810077(+) gagccG/Aataac 1 -- us2k19Minor allele frequency- A:0.47NA NS WA CSA EA 516
    rs1510988461,2
    --44810216(+) TTTTCG/TTAACA 1 -- us2k10--------
    rs1410967601,2
    --44810254(+) TTTTAC/TATTTT 1 -- us2k10--------
    rs178600411,2
    C,F--44810434(+) TTTTTC/AGTAGA 1 -- us2k13Minor allele frequency- A:0.04NS NA 180
    rs1849764331,2
    --44810501(+) CTCCCA/GCCTCG 1 -- us2k10--------
    rs1123395191,2
    C,F--44810502(+) TCCCGC/TCTCGG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1923389681,2
    --44810534(+) CAGGCG/TTGATC 1 -- us2k10--------
    rs47204851,2
    C,F,A,H--44810682(+) GCGCCA/TCGACG 1 -- us2k111Minor allele frequency- T:0.20NS WA NA CSA EA 536

    HapMap Linkage Disequilibrium report for PPIA (44836241 - 44864163 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PPIA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830985CNV Loss17160897

    Human Gene Mutation Database (HGMD): PPIA
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PPIA
    DNA2.0 Custom Variant and Variant Library Synthesis for PPIA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123840    OMIM disorders: --

    1 disease for PPIA:    
    About MalaCards
    in situ carcinoma


    Find genes that share disorders with PPIA           About GenesLikeMe

    10 Novoseek inferred disease relationships for PPIA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 44 12 10208939 (1), 15542632 (1), 17267487 (1), 16501094 (1) (see all 12)
    pancreatic cancer 5.67 14 16604531 (7), 16226951 (4)
    virus infection 2.66 1 19865066 (1)
    lupus erythematosus systemic 0 2 1591884 (1), 1458678 (1)
    leukemia 0 2 14526201 (1), 16501094 (1)
    shock 0 1 17996735 (1)
    cancer lung 0 1 17678621 (1)
    aids 0 1 17590083 (1)
    tumors 0 13 17520256 (3), 17996735 (1), 19865066 (1), 17678621 (1) (see all 5)
    cancer 0 14 19865066 (5), 17094902 (1), 17520256 (1), 16604531 (1)

    Genetic Association Database (GAD): PPIA
    Human Genome Epidemiology (HuGE) Navigator: PPIA (5 documents)

    Export disorders for PPIA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPIA gene, integrated from 10 sources (see all 388):
    (articles sorted by number of sources associating them with PPIA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human cyclophilin gene and of related processed pseudogenes. (PubMed id 2197089)1, 2, 3 Haendler B. and Hofer E. (Eur. J. Biochem. 1990)
    2. Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. (PubMed id 17590083)1, 4, 9 An P....Winkler C.A. (PLoS Pathog. 2007)
    3. Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. (PubMed id 20364129)1, 2 Lammers M.... James L.C. (Nat. Chem. Biol. 2010)
    4. Polymorphisms in the regulatory region of the Cyclophilin A gene influence the susceptibility for HIV-1 infection. (PubMed id 19092998)1, 4 Rits M.A....Kootstra N.A. (PLoS ONE 2008)
    5. A search for cyclophilin-A gene (PPIA) variation and its contribution to the risk of atherosclerosis and myocardial infarction. (PubMed id 18321308)1, 4 PalacA-n M....Coto E. (Int. J. Immunogenet. 2008)
    6. A search for cyclophilin-A gene variants in cyclosporine A-treated renal transplanted patients. (PubMed id 18673375)1, 4 Moscoso-Solorzano G.T....Coto E. (Clin Transplant 2008)
    7. Fusion of cyclophilin A to Fv1 enables cyclosporine-sensitive restriction of human and feline immunodeficiency viruses. (PubMed id 17609268)1, 7 Schaller T....Towers G.J. (J. Virol. 2007)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    10. Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. (PubMed id 12218175)1, 2 Huai Q.... Ke H. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5478 HGNC: 9253 AceView: PPIA Ensembl:ENSG00000196262 euGenes: HUgn5478
    ECgene: PPIA H-InvDB: PPIA

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPIA Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ppia/
    Wikipedia http://en.wikipedia.org/wiki/Cyclophilin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPIA gene:
    Search GeneIP for patents involving PPIA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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