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Aliases for PPIA Gene

Aliases for PPIA Gene

  • Peptidylprolyl Isomerase A 2 3
  • Peptidylprolyl Isomerase A (Cyclophilin A) 3 5
  • Cyclosporin A-Binding Protein 3 4
  • Cyclophilin A 2 4
  • Rotamase A 3 4
  • EC 4 63
  • PPIase A 3 4
  • CYPA 3 4
  • Epididymis Secretory Sperm Binding Protein Li 69p 3
  • T Cell Cyclophilin 3
  • HEL-S-69p 3
  • CYPH 3

External Ids for PPIA Gene

Previous GeneCards Identifiers for PPIA Gene

  • GC07P044482
  • GC07P044543
  • GC07P044577
  • GC07P044609
  • GC07P044803
  • GC07P044841
  • GC07P044798
  • GC07P044799

Summaries for PPIA Gene

Entrez Gene Summary for PPIA Gene

  • This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIA Gene

PPIA (Peptidylprolyl Isomerase A) is a Protein Coding gene. Diseases associated with PPIA include nodular nonsuppurative panniculitis and denture stomatitis. Among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and NF-kappaB Signaling. GO annotations related to this gene include poly(A) RNA binding and peptide binding. An important paralog of this gene is PPIAL4A.

UniProtKB/Swiss-Prot for PPIA Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Gene Wiki entry for PPIA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIA Gene

Genomics for PPIA Gene

Regulatory Elements for PPIA Gene

Enhancers for PPIA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPIA on UCSC Golden Path with GeneCards custom track

Promoters for PPIA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPIA on UCSC Golden Path with GeneCards custom track

Genomic Location for PPIA Gene

44,796,636 bp from pter
44,824,564 bp from pter
27,929 bases
Plus strand

Genomic View for PPIA Gene

Genes around PPIA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIA Gene

Proteins for PPIA Gene

  • Protein details for PPIA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A
    Protein Accession:
    Secondary Accessions:
    • A8K220
    • P05092
    • Q3KQW3
    • Q567Q0
    • Q6IBU5
    • Q96IX3
    • Q9BRU4
    • Q9BTY9
    • Q9UC61

    Protein attributes for PPIA Gene

    165 amino acids
    Molecular mass:
    18012 Da
    Quaternary structure:
    • Interacts with HIV-1 Capsid protein.

    Three dimensional structures from OCA and Proteopedia for PPIA Gene

    Alternative splice isoforms for PPIA Gene


neXtProt entry for PPIA Gene

Proteomics data for PPIA Gene at MOPED

Post-translational modifications for PPIA Gene

  • Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition.
  • Ubiquitination at Lys 31, Lys 49, Lys 82, Lys 91, Lys 131, Lys 133, and Lys 155
  • Glycosylation at Asn 108
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PPIA (PPIA)

Domains & Families for PPIA Gene

Gene Families for PPIA Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
genes like me logo Genes that share domains with PPIA: view

Function for PPIA Gene

Molecular function for PPIA Gene

GENATLAS Biochemistry:
cyclophilin A,major intracellular receptor for the immunosuppressive agent cyclosporine A,with intrinsic peptidyl-prolyl cis-trans isomerase activity
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Enzyme Numbers (IUBMB) for PPIA Gene

Gene Ontology (GO) - Molecular Function for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12730686
genes like me logo Genes that share ontologies with PPIA: view
genes like me logo Genes that share phenotypes with PPIA: view

Animal Models for PPIA Gene

MGI Knock Outs for PPIA:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPIA Gene

Localization for PPIA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIA Gene

Cytoplasm. Secreted. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.

Subcellular locations from

Jensen Localization Image for PPIA Gene COMPARTMENTS Subcellular localization image for PPIA gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PPIA Gene

Pathways & Interactions for PPIA Gene

genes like me logo Genes that share pathways with PPIA: view

Pathways by source for PPIA Gene

Gene Ontology (GO) - Biological Process for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IDA 14993672
GO:0016032 viral process TAS --
GO:0019061 uncoating of virus TAS --
GO:0019064 fusion of virus membrane with host plasma membrane TAS --
GO:0019068 virion assembly TAS --
genes like me logo Genes that share ontologies with PPIA: view

No data available for SIGNOR curated interactions for PPIA Gene

Drugs & Compounds for PPIA Gene

(13) Drugs for PPIA Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Proline Approved Nutra Target, binder 0
Cyclosporine Approved, Investigational Pharma Target Immunosuppressant drug 0
(3r)-1-Acetyl-3-Methylpiperidine Experimental Pharma Target 0
(3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl- Experimental Pharma Target 0
Ethyl Oxo(Piperidin-1-Yl)Acetate Experimental Pharma Target 0

(3) Additional Compounds for PPIA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for PPIA Gene

Compound Action Cas Number
Cyclosporin A Immunosuppressive agent 59865-13-3
genes like me logo Genes that share compounds with PPIA: view

Transcripts for PPIA Gene

Unigene Clusters for PPIA Gene

Peptidylprolyl isomerase A (cyclophilin A):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPIA Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
SP1: -
SP2: -
SP3: - -
SP4: -

Relevant External Links for PPIA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPIA Gene

mRNA expression in normal human tissues for PPIA Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIA Gene

SOURCE GeneReport for Unigene cluster for PPIA Gene Hs.356331

genes like me logo Genes that share expression patterns with PPIA: view

Protein tissue co-expression partners for PPIA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPIA Gene

Orthologs for PPIA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100337215 35
  • 94.51 (n)
  • 97.56 (a)
  • 93 (a)
(Canis familiaris)
Mammalia PPIA 35
  • 88.28 (n)
  • 95.86 (a)
  • 75 (a)
(Mus musculus)
Mammalia Ppia 35
  • 92.48 (n)
  • 96.34 (a)
Ppia 16
Gm10123 36
  • 96 (a)
Gm5160 36
  • 85 (a)
Ppia 36
  • 96 (a)
(Pan troglodytes)
Mammalia PPIA 35
  • 99.39 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ppia 35
  • 92.68 (n)
  • 96.34 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
(Gallus gallus)
Aves PPIA 35
  • 81.71 (n)
  • 90.85 (a)
  • 90 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496569 35
  • 67.27 (n)
  • 72.12 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398630 35
(Danio rerio)
Actinopterygii ppiaa 35
  • 69.92 (n)
  • 73.78 (a)
wufd61c06 35
  • 1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7768 37
  • 74 (a)
Cyp1 37
  • 74 (a)
CG5071 36
  • 7 (a)
(Caenorhabditis elegans)
Secernentea cyp-3 37
  • 67 (a)
cyp-7 37
  • 64 (a)
cyp-8 37
  • 52 (a)
cyn-1 35
  • 65.43 (n)
  • 72.84 (a)
T22F3.12 36
  • 45 (a)
Y17G9B.4 36
  • 22 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER156C 35
  • 63.96 (n)
  • 64.37 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04565g 35
  • 61.62 (n)
  • 63.03 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR3 35
  • 59.33 (n)
  • 65.41 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ROC2 35
  • 66.46 (n)
  • 73.33 (a)
(Glycine max)
eudicotyledons Gma.12280 35
(Oryza sativa)
Liliopsida Os09g0571400 35
  • 66.05 (n)
  • 72.84 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2570 36
  • 5 (a)
Species with no ortholog for PPIA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIA Gene

Gene Tree for PPIA (if available)
Gene Tree for PPIA (if available)

Paralogs for PPIA Gene Pseudogenes for PPIA Gene

genes like me logo Genes that share paralogs with PPIA: view

Variants for PPIA Gene

Sequence variations from dbSNP and Humsavar for PPIA Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1059983 -- 44,799,764(+) TTTGA(A/T)GATGA reference, missense
rs6956212 -- 44,803,351(+) gtgta(C/T)gccac downstream-variant-500B
rs12702088 -- 44,800,660(+) ccccc(A/G)aagtg intron-variant
rs7784201 -- 44,802,289(+) GATAA(C/T)GGGCG utr-variant-3-prime
rs17850033 -- 44,799,778(+) CTTCA(C/T)CCTAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PPIA Gene

Variant ID Type Subtype PubMed ID
nsv830985 CNV Loss 17160897

Variation tolerance for PPIA Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIA Gene

Disorders for PPIA Gene

MalaCards: The human disease database

(5) MalaCards diseases for PPIA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
nodular nonsuppurative panniculitis
  • nodular non-suppurative febrile panniculitis
denture stomatitis
  • denture sore mouth
in situ carcinoma
  • carcinoma in situ
  • aids, slow progression to
hepatitis c virus
  • hepatitic c virus
- elite association - COSMIC cancer census association via MalaCards
Search PPIA in MalaCards View complete list of genes associated with diseases

Relevant External Links for PPIA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PPIA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPIA Gene

Publications for PPIA Gene

  1. Characterization of the human cyclophilin gene and of related processed pseudogenes. (PMID: 2197089) Haendler B. … Hofer E. (Eur. J. Biochem. 1990) 2 3 4 67
  2. EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation. (PMID: 19758589) Seizer P. … May A.E. (Atherosclerosis 2010) 3 23
  3. Cyclophilin A: potential functions and therapeutic target for human cancer. (PMID: 19865066) Obchoei S. … Chen C. (Med. Sci. Monit. 2009) 3 23
  4. Oligo-microarray analysis reveals the role of cyclophilin A in drug resistance. (PMID: 17520256) Chen S. … Yu L. (Cancer Chemother. Pharmacol. 2008) 3 23
  5. Cyclophilin A is required for CXCR4-mediated nuclear export of heterogeneous nuclear ribonucleoprotein A2, activation and nuclear translocation of ERK1/2, and chemotactic cell migration. (PMID: 17991743) Pan H. … Fan G.H. (J. Biol. Chem. 2008) 3 23

Products for PPIA Gene

Sources for PPIA Gene