PPIA Gene
protein-coding GIFtS: 68
GCID: GC07P044803
|
|
peptidylprolyl isomerase A (cyclophilin A)
| |
Aliases
for PPIA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Peptidylprolyl Isomerase A (Cyclophilin A)1 2 | | CYPH2 | | CYPA1 2 3 | | Cyclophilin1 | | Cyclosporin A-Binding Protein2 3 | | Peptidyl-Prolyl Cis-Trans Isomerase A2 | | Rotamase A2 3 | | T Cell Cyclophilin2 | | PPIase A2 3 | | Cyclophilin A3 | | EC 5.2.1.83 8 | | |
Export aliases for PPIA gene to outside databasesPrevious GC identifers: GC07P044482 GC07P044543 GC07P044577 GC07P044609 |
Summaries
for PPIA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PPIA:
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-transisomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encodedprotein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The proteincan also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to benecessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes havebeen reported. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PPIA_HUMAN, P62937Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidicpeptide bonds in oligopeptides
Gene Wiki entry for PPIA (Peptidylprolyl isomerase A)
|
Genomic Views
for PPIA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PPIA gene promoter:
SRF AML1a SRF (504 AA) Nkx3-1 v1 PPAR-alpha MZF-1 ZIC2/Zic2 ATF ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for PPIA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p13 Ensembl cytogenetic band: 7p13 HGNC cytogenetic band: 7p13PPIA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P044803: view genomic region
(about GC identifiers)
Start:
|
44,836,241 bp from pter |
End:
|
44,864,163 bp from pter |
Size:
|
27,923 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 44,875,748-44,882,224 |
|
Proteins
for PPIA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PPIA_HUMAN, P62937 (See
protein sequence)Recommended Name: Peptidyl-prolyl cis-trans isomerase A Size: 165 amino acids; 18012 Da
Subunit: Interacts with HIV-1 Capsid protein
Subcellular location: Cytoplasm. Secreted. Note=Secretion occurs in response to oxidative stress in vascular smoothmuscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediatesERK1/2 activation
6/62 PDB 3D structures from  and Proteopedia  for PPIA (see all 62):1AK4 (3D)
1AWQ (3D)
1AWR (3D)
1AWS (3D)
1AWT (3D)
1AWU (3D)
Secondary accessions: A8K220 P05092 Q3KQW3 Q6IBU5 Q96IX3 Q9BRU4 Q9BTY9 Q9UC61Explore the universe of human proteins at neXtProt for PPIA: NX_P62937
Post-translational modifications:
Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than transforms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine byinhibiting the sequential steps of cyclosporine binding and calcineurin inhibition1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P62937
4/16 DME Specific Peptides for PPIA (P62937) (see all 16)
PPIA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066953.1
ENSEMBL proteins: ENSP00000405975 ENSP00000419425 ENSP00000427976 ENSP00000430817 ENSP00000429251 ENSP00000394670 Reactome Protein details: P62937
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
PPIA for ontologies About GeneDecksing
PPIA Antibody Products:
Assay Products for PPIA: |
Protein
Domains /
Families
for PPIA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PPIA for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P62937ProtoNet protein and cluster: P62937 1 Blocks protein family: IPB002130 Peptidyl-prolyl cis-trans isomerase
UniProtKB/Swiss-Prot: PPIA_HUMAN, P62937Similarity: Belongs to the cyclophilin-type PPIase family. PPIase A subfamilySimilarity: Contains 1 PPIase cyclophilin-type domain |
Function
for PPIA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PPIA_HUMAN, P62937Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidicpeptide bonds in oligopeptidesCatalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)Enzyme regulation: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase Genatlas biochemistry entry for PPIA:cyclophilin A,major intracellular receptor for the immunosuppressive agent cyclosporine A,with intrinsicpeptidyl-prolyl cis-trans isomerase activity
Enzyme Number (IUBMB): EC 5.2.1.81 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PPIA (NM_021130) | |  | Sino Biological Human cDNA Clone for PPIA | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPIA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIA |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
PPIA for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Ppiatm1Lubn for PPIA
8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ppia):
PPIA for phenotypes About GeneDecksing
|
Pathways & Interactions
for PPIA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Plus-strand DNA synthesis | | | 2 | Platelet activation, signaling and aggregation | | | 3 | HIV Infection | | | 4 | Platelet degranulation | | | 5 | Lymphocyte Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for PPIA
1  GeneGo (Thomson Reuters) Pathway for PPIA
1  BioSystems Pathway for PPIA
5/19 
Reactome Pathways for PPIA (see all 19)
1  PharmGKB Pathway for PPIA
PPIA for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPIA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/109 Interacting proteins for PPIA (P629371, 2, 3 ENSP000004194254) via UniProtKB, MINT, STRING, and/or I2D (see all 109)About this table
Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table
PPIA for ontologies About GeneDecksing
|
Drugs & Compounds
for PPIA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PPIA for compounds About GeneDecksing
 Browse Tocris compounds for PPIA
1 HMDB Compound for PPIA About this table
5 DrugBank Compounds for PPIA About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| Cyclosporine | Ciclosporin (see all 3) | 59865-13-3 | target | -- | 17609268 20368803 17461417 20637127 16849427 16641261 | | (3r)-1-Acetyl-3-Methylpiperidine | -- | -- | target | -- | 17139284 17016423 10592235 | | (3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl- | -- | -- | target | -- | 17139284 17016423 10592235 | | L-Proline | (-)-2-Pyrrolidinecarboxylic acid (see all 6) | 147-85-3 | target | binder | 17139284 11752352 17016423 | | Ethyl Oxo(Piperidin-1-Yl)Acetate | -- | 53074-96-7 | target | -- | 10592235 |
10 Novoseek chemical compound relationships for PPIA gene About this table
Search CenterWatch for drugs/clinical trials and news about PPIA
|
Transcripts
for PPIA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PPIA gene (3 alternative transcripts): NM_021130.3 NM_203430.1 NM_203431.1 Unigene Cluster for PPIA: Peptidylprolyl isomerase A (cyclophilin A) Hs.356331 [show with all ESTs]Unigene Representative Sequence: NM_0211309 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000481437 ENST00000451562 ENST00000468812(uc003tlw.3 uc003tlx.3 uc010kyl.3)
ENST00000489459 ENST00000355968 ENST00000479021 ENST00000415933 ENST00000494484
ENST00000480603
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PPIA (NM_021130) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPIA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIA |
Additional cDNA sequence: AB451307.1 AB451438.1 AK026569.1 AK130101.1 AK290085.1 AK290851.1 AK293003.1 AK297340.1 AK316564.1 BC000689.2 BC003026.1 BC005320.1 BC005982.1 BC007104.1 BC013915.1 BC018843.2 BC073992.1 BC093076.1 BC106030.1 BC137057.1 BC137058.1 CR456707.1 Y00052.1 24/112 DOTS entries (see all 112): DT.95376662 DT.91782512 DT.220845 DT.91782568 DT.91782539 DT.100846396 DT.121123710 DT.91782522 DT.102845567 DT.100866435 DT.95377532 DT.100713075 DT.100713079 DT.100060454 DT.121123866 DT.97870652 DT.95377102 DT.100018218 DT.100060460 DT.100713073 DT.100713093 DT.100713057 DT.121123721 DT.100713091 24/3717 AceView cDNA sequences (see all 3717): BQ219418 BM912530 N53247 AI394543 BG476792 CN482182 BG105059 BI494053 BC013915 BU153385 BQ926413 BU174928 AA363839 BG108007 BE259537 AW674796 BE789128 CA445805 CB136013 BX428761 BG165962 AJ713353 BM694036 AW778760
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for PPIA About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for PPIA
|
Expression
for PPIA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PPIA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTAGCTGGA
About this image
See PPIA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPIA
SOURCE GeneReport for Unigene cluster: Hs.356331
SABiosciences Expression via Pathway-Focused PCR Arrays including PPIA:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPIA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPIA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIA |
Orthologs
for PPIA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PPIA gene from 8/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PPIA6 |
-- |
88(a) |
1 → many |
Un(21112177-21112524) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
90(a) |
1 → many |
GL343238.1(670858-675712) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3986302 |
hypothetical protein LOC398630 |
76.15(n) |
|
BC054186.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufd61c062 |
Transcribed sequence with moderate similarity to protein more |
77.68(n) |
|
57059550 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Cyp13
CG77681 |
protein folding cyclin-dependent protein
kinase, more3
CG77681 |
74(a)
(best of 2)3
65.63(n)1
74.53(a)1 |
|
14B123
395731 NM_168584.21 NP_729966.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
cyp-33
cyn-71 |
Peptidyl-prolyl cis-trans isomerases3
Protein CYN-71 |
67(a)
(best of 3)3
64.63(n)1
71.34(a)1 |
|
V(15192351-15193440)3
1800271 NM_074348.61 NP_506749.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ROC51 |
Peptidyl-prolyl cis-trans isomerase CYP18-4 |
66.87(n)
73.17(a) |
|
829639 NM_119653.3 NP_195213.1 |
rice
(Oryza sativa) |
Liliopsida |
Os02g01213001 |
hypothetical protein |
65.85(n)
71.95(a) |
|
4328121 NM_001052252.1 NP_001045717.1 |
ENSEMBL Gene Tree for PPIA (if available)
TreeFam Gene Tree for PPIA (if available) |
Paralogs
for PPIA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PPIA gene
- PPIE2 PPIAL4A2 PPIAL4C2 PPIAL4G2 PPIF2 PPIAL4B2 PPIAL4D2
18/23 SIMAP similar genes for PPIA using alignment to 5 protein entries: PPIA_HUMAN (see all proteins)
(see all similar genes):LOC388817 PPIAL4A PPIAL4B PPIAL4C PPIAL4G PPIF
RANBP2 PPIE LOC402252 PPIB PPIC PPID
PPIH PPIL1 CWC27 PPIL3 PPIL2 PPIG
PPIA for paralogs About GeneDecksing
5/99 Pseudogenes.org Pseudogenes for PPIA (see all 99)
PGOHUM00000238365 PGOHUM00000238396 PGOHUM00000238539 PGOHUM00000238620 PGOHUM00000238630
|
Genomic Variants
for PPIA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PPIA (44836241 - 44864163 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PPIA: --
Human Gene Mutation Database (HGMD): PPIA
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for PPIA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PPIA for disorders About GeneDecksing
OMIM gene information: 123840
OMIM disorders: --
20/44  diseases for PPIA (see all 44): About MalaCardssevere acute respiratory syndrome lupus erythematosus systemic lupus erythematosus male breast cancer
lyme disease myocardial infarction renal cell carcinoma squamous cell carcinoma
multiple myeloma rheumatoid arthritis hepatitis c stomatitis
endocarditis pancreatic cancer endometrial carcinoma hepatitis b
carcinoma migraine breast cancer copd
10 Novoseek disease relationships for PPIA gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| immunodeficiency |
44 |
12 |
10208939 (1), 15542632 (1), 17267487 (1), 16501094 (1) (see all 12) |
| pancreatic cancer |
5.67 |
14 |
16604531 (7), 16226951 (4) |
| virus infection |
2.66 |
1 |
19865066 (1) |
| lupus erythematosus systemic |
0 |
2 |
1591884 (1), 1458678 (1) |
| leukemia |
0 |
2 |
14526201 (1), 16501094 (1) |
| shock |
0 |
1 |
17996735 (1) |
| cancer lung |
0 |
1 |
17678621 (1) |
| aids |
0 |
1 |
17590083 (1) |
| tumors |
0 |
13 |
17520256 (3), 17996735 (1), 19865066 (1), 17678621 (1) (see all 5) |
| cancer |
0 |
14 |
19865066 (5), 17094902 (1), 17520256 (1), 16604531 (1) |
Human Genome Epidemiology (HuGE) Navigator: PPIA (5 documents)
Export disorders for PPIA gene to outside databases
|
Publications
for PPIA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PPIA gene, integrated from 9 sources (see all 358):
(articles sorted by number of sources associating them with PPIA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the human cyclophilin gene and of related processed pseudogenes. (PubMed id 2197089)1, 2, 3 Haendler B. and Hofer E. (1990)
- Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. (PubMed id 20364129)1, 2 Lammers M.... James L.C. (2010)
- Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1, 2 Meierhofer D.... Kaiser P. (2008)
- Fusion of cyclophilin A to Fv1 enables cyclosporine-s ensitive restriction of human and feline immunodeficiency viruses. (PubMed id 17609268)1, 7 Schaller T....Towers G.J. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. (PubMed id 12218175)1, 2 Huai Q.... Ke H. (2002)
- Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. (PubMed id 12357034)1, 2 Jin L. and Harrison S.C. (2002)
- X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A. (PubMed id 9769216)1, 2 Kallen J.... Walkinshaw M.D. (1998)
- The NMR solution conformation of unligated human cyclophilin A. (PubMed id 9299338)1, 2 Ottiger M.... Wuethrich K. (1997)
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External Searches for PPIA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PPIA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing PPIA gene
(According to HUGE)
About This Section
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Specialized Databases showing PPIA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PPIA | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/ppia/ | | Wikipedia | http://en.wikipedia.org/wiki/Cyclophilin |
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About This Section
| Patent Information for PPIA gene:
Search GeneIP for patents involving PPIA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PPIA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for PPIA | | OriGene shRNA RFP for PPIA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPIA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPIA | | | OriGene Protein Over-expression Lysate for PPIA | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for PPIA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPIA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPIA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PPIA | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PPIA | | OriGene Custom Protein Services for PPIA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPIA | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPIA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPIA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPIA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPIA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPIA |
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| | Antibodies & Assays for PPIA |
| | | | Search Tocris compounds for PPIA |
| |  |  |  |  | | | | | | Recombinant Protein for PPIA |
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 | | | PPIA Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPIA |
|  |  |  | | | | ThermoFisher Antibody for PPIA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPIA |
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