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Aliases for PPIA Gene

Aliases for PPIA Gene

  • Peptidylprolyl Isomerase A (Cyclophilin A) 2 3
  • Cyclosporin A-Binding Protein 3 4
  • Rotamase A 3 4
  • EC 5.2.1.8 4 64
  • PPIase A 3 4
  • CYPA 3 4
  • Epididymis Secretory Sperm Binding Protein Li 69p 3
  • Peptidyl-Prolyl Cis-Trans Isomerase A 3
  • T Cell Cyclophilin 3
  • Cyclophilin A 4
  • HEL-S-69p 3
  • CYPH 3

External Ids for PPIA Gene

Summaries for PPIA Gene

Entrez Gene Summary for PPIA Gene

  • This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIA Gene

PPIA (Peptidylprolyl Isomerase A (Cyclophilin A)) is a Protein Coding gene. Diseases associated with PPIA include in situ carcinoma and hiv-1. Among its related pathways are Disease and Hemostasis. GO annotations related to this gene include unfolded protein binding and peptide binding. An important paralog of this gene is PPIE.

UniProtKB/Swiss-Prot for PPIA Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Gene Wiki entry for PPIA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIA Gene

Genomics for PPIA Gene

Genomic Location for PPIA Gene

Start:
44,796,642 bp from pter
End:
44,824,564 bp from pter
Size:
27,923 bases
Orientation:
Plus strand

Genomic View for PPIA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPIA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIA Gene

Regulatory Elements for PPIA Gene

Proteins for PPIA Gene

  • Protein details for PPIA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62937-PPIA_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A
    Protein Accession:
    P62937
    Secondary Accessions:
    • A8K220
    • P05092
    • Q3KQW3
    • Q567Q0
    • Q6IBU5
    • Q96IX3
    • Q9BRU4
    • Q9BTY9
    • Q9UC61

    Protein attributes for PPIA Gene

    Size:
    165 amino acids
    Molecular mass:
    18012 Da
    Quaternary structure:
    • Interacts with HIV-1 Capsid protein.

    Three dimensional structures from OCA and Proteopedia for PPIA Gene

    Alternative splice isoforms for PPIA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIA Gene

Proteomics data for PPIA Gene at MOPED

Post-translational modifications for PPIA Gene

  • Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys31, Lys44, Lys49, Lys76, Lys82, Lys91, Lys118, Lys125, Lys131, Lys133, and Lys155
  • Glycosylation at Asn108

Other Protein References for PPIA Gene

Domains for PPIA Gene

UniProtKB/Swiss-Prot:

PPIA_HUMAN
Domain:
  • Contains 1 PPIase cyclophilin-type domain.:
    • P62937
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.:
    • P62937
genes like me logo Genes that share domains with PPIA: view

No data available for Gene Families for PPIA Gene

Function for PPIA Gene

Molecular function for PPIA Gene

GENATLAS Biochemistry: cyclophilin A,major intracellular receptor for the immunosuppressive agent cyclosporine A,with intrinsic peptidyl-prolyl cis-trans isomerase activity
UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot EnzymeRegulation: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase
UniProtKB/Swiss-Prot Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Enzyme Numbers (IUBMB) for PPIA Gene

Gene Ontology (GO) - Molecular Function for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA 14993672
GO:0005515 protein binding IPI 12730686
GO:0042277 peptide binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046790 virion binding NAS 11250896
genes like me logo Genes that share ontologies with PPIA: view
genes like me logo Genes that share phenotypes with PPIA: view

Animal Models for PPIA Gene

MGI Knock Outs for PPIA:

No data available for Transcription Factor Targeting and HOMER Transcription for PPIA Gene

Localization for PPIA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIA Gene

Cytoplasm. Secreted. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIA Gene COMPARTMENTS Subcellular localization image for PPIA gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IDA 16780588
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with PPIA: view

Pathways for PPIA Gene

genes like me logo Genes that share pathways with PPIA: view

Pathways by source for PPIA Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for PPIA Gene
1 Cell Signaling Technology pathway for PPIA Gene
1 BioSystems pathway for PPIA Gene

Gene Ontology (GO) - Biological Process for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IDA 14993672
GO:0002576 platelet degranulation TAS --
GO:0006278 RNA-dependent DNA replication TAS --
GO:0006457 protein folding TAS 2179953
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with PPIA: view

Compounds for PPIA Gene

(1) HMDB Compounds for PPIA Gene

Compound Synonyms Cas Number PubMed IDs
L-Proline
  • (-)-(S)-Proline
147-85-3

(10) Novoseek inferred chemical compound relationships for PPIA Gene

Compound -log(P) Hits PubMed IDs
cyclosporin a 76.1 49
glyceraldehyde 3-phosphate 56.1 5
heparan sulfate 34 1
tacrolimus 30.3 2
proline 7.47 2
genes like me logo Genes that share compounds with PPIA: view

Transcripts for PPIA Gene

Unigene Clusters for PPIA Gene

Peptidylprolyl isomerase A (cyclophilin A):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPIA Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
SP1: -
SP2: -
SP3: - -
SP4: -

Relevant External Links for PPIA Gene

GeneLoc Exon Structure for
PPIA
ECgene alternative splicing isoforms for
PPIA

Expression for PPIA Gene

mRNA expression in normal human tissues for PPIA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPIA Gene

SOURCE GeneReport for Unigene cluster for PPIA Gene Hs.356331

genes like me logo Genes that share expressions with PPIA: view

Orthologs for PPIA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPIA 36
  • 99.39 (n)
  • 100 (a)
PPIA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100337215 36
  • 94.51 (n)
  • 97.56 (a)
PPIA 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPIA 36
  • 88.28 (n)
  • 95.86 (a)
PPIA 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm10123 37
  • 96 (a)
OneToMany
Gm5160 37
  • 85 (a)
OneToMany
Ppia 36
  • 92.48 (n)
  • 96.34 (a)
Ppia 16
Ppia 37
  • 96 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 93 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ppia 36
  • 92.68 (n)
  • 96.34 (a)
chicken
(Gallus gallus)
Aves PPIA 36
  • 81.71 (n)
  • 90.85 (a)
PPIA 37
  • 90 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 90 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC398630 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496569 36
  • 67.27 (n)
  • 72.12 (a)
zebrafish
(Danio rerio)
Actinopterygii PPIA 37
  • 1 (a)
OneToMany
ppiaa 36
  • 69.92 (n)
  • 73.78 (a)
wufd61c06 36
fruit fly
(Drosophila melanogaster)
Insecta CG5071 37
  • 7 (a)
OneToMany
CG7768 38
  • 74 (a)
Cyp1 38
  • 74 (a)
worm
(Caenorhabditis elegans)
Secernentea cyn-1 36
  • 65.43 (n)
  • 72.84 (a)
T22F3.12 37
  • 45 (a)
ManyToMany
Y17G9B.4 37
  • 22 (a)
ManyToMany
cyp-8 38
  • 52 (a)
cyp-3 38
  • 67 (a)
cyp-7 38
  • 64 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER156C 36
  • 63.96 (n)
  • 64.37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR3 36
  • 59.33 (n)
  • 65.41 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04565g 36
  • 61.62 (n)
  • 63.03 (a)
soybean
(Glycine max)
eudicotyledons Gma.12280 36
thale cress
(Arabidopsis thaliana)
eudicotyledons ROC2 36
  • 66.46 (n)
  • 73.33 (a)
rice
(Oryza sativa)
Liliopsida Os09g0571400 36
  • 66.05 (n)
  • 72.84 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2570 37
  • 5 (a)
OneToMany
Species with no ortholog for PPIA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIA Gene

ENSEMBL:
Gene Tree for PPIA (if available)
TreeFam:
Gene Tree for PPIA (if available)

Paralogs for PPIA Gene

Pseudogenes.org Pseudogenes for PPIA Gene

genes like me logo Genes that share paralogs with PPIA: view

Variants for PPIA Gene

Sequence variations from dbSNP and Humsavar for PPIA Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4205 -- 44,802,834(-) AGGGG(-/TT)TTCTC utr-variant-3-prime
rs6850 -- 44,796,715(+) CGTGT(A/G)CTATT utr-variant-5-prime
rs6904 -- 44,802,822(-) TTAGA(C/T)TGTCC utr-variant-3-prime
rs14869 -- 44,802,946(-) TAAAA(A/C)AAAAA utr-variant-3-prime
rs725645 -- 44,798,538(+) ATAAG(A/T)GAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPIA Gene

Variant ID Type Subtype PubMed ID
nsv830985 CNV Loss 17160897

Relevant External Links for PPIA Gene

HapMap Linkage Disequilibrium report
PPIA
Human Gene Mutation Database (HGMD)
PPIA

Disorders for PPIA Gene

(2) MalaCards Diseases for PPIA Gene

Search for PPIA Gene in MalaCards »

(10) Novoseek inferred disease relationships for PPIA Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 44 12
pancreatic cancer 5.67 11
virus infection 2.66 1
lupus erythematosus systemic 0 2
leukemia 0 2

Relevant External Links for PPIA

Genetic Association Database (GAD)
PPIA
Human Genome Epidemiology (HuGE) Navigator
PPIA
genes like me logo Genes that share disorders with PPIA: view

No data available for UniProtKB/Swiss-Prot for PPIA Gene

Publications for PPIA Gene

  1. Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. (PMID: 17590083) An P. … Winkler C.A. (PLoS Pathog. 2007) 3 23 49
  2. Characterization of the human cyclophilin gene and of related processed pseudogenes. (PMID: 2197089) Haendler B. … Hofer E. (Eur. J. Biochem. 1990) 2 3 4
  3. A search for cyclophilin-A gene (PPIA) variation and its contribution to the risk of atherosclerosis and myocardial infarction. (PMID: 18321308) PalacA-n M. … Coto E. (Int. J. Immunogenet. 2008) 3 49
  4. Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein. (PMID: 9385632) Vajdos F.F. … Hill C.P. (Protein Sci. 1997) 3 4
  5. Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. (PMID: 12218175) Huai Q. … Ke H. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4

Products for PPIA Gene

Sources for PPIA Gene

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