Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPIA Gene

Aliases for PPIA Gene

  • Peptidylprolyl Isomerase A 2 3 5
  • Cyclosporin A-Binding Protein 3 4
  • Cyclophilin A 2 4
  • Rotamase A 3 4
  • EC 5.2.1.8 4 61
  • PPIase A 3 4
  • CYPA 3 4
  • Epididymis Secretory Sperm Binding Protein Li 69p 3
  • Peptidylprolyl Isomerase A (Cyclophilin A) 3
  • Peptidyl-Prolyl Cis-Trans Isomerase A 3
  • T Cell Cyclophilin 3
  • HEL-S-69p 3
  • CYPH 3

External Ids for PPIA Gene

Previous GeneCards Identifiers for PPIA Gene

  • GC07P044482
  • GC07P044543
  • GC07P044577
  • GC07P044609
  • GC07P044803
  • GC07P044841
  • GC07P044798
  • GC07P044799
  • GC07P044800

Summaries for PPIA Gene

Entrez Gene Summary for PPIA Gene

  • This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPIA Gene

PPIA (Peptidylprolyl Isomerase A) is a Protein Coding gene. Diseases associated with PPIA include Diffuse Intrinsic Pontine Glioma and In Situ Carcinoma. Among its related pathways are Platelet activation, signaling and aggregation and Minus-strand DNA synthesis. GO annotations related to this gene include poly(A) RNA binding and peptide binding. An important paralog of this gene is PPIAL4C.

UniProtKB/Swiss-Prot for PPIA Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Gene Wiki entry for PPIA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPIA Gene

Genomics for PPIA Gene

Regulatory Elements for PPIA Gene

Enhancers for PPIA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PPIA on UCSC Golden Path with GeneCards custom track

Promoters for PPIA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPIA on UCSC Golden Path with GeneCards custom track

Genomic Location for PPIA Gene

Chromosome:
7
Start:
44,796,636 bp from pter
End:
44,824,564 bp from pter
Size:
27,929 bases
Orientation:
Plus strand

Genomic View for PPIA Gene

Genes around PPIA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPIA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPIA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPIA Gene

Proteins for PPIA Gene

  • Protein details for PPIA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62937-PPIA_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A
    Protein Accession:
    P62937
    Secondary Accessions:
    • A8K220
    • P05092
    • Q3KQW3
    • Q567Q0
    • Q6IBU5
    • Q96IX3
    • Q9BRU4
    • Q9BTY9
    • Q9UC61

    Protein attributes for PPIA Gene

    Size:
    165 amino acids
    Molecular mass:
    18012 Da
    Quaternary structure:
    • Interacts with HIV-1 Capsid protein.

    Three dimensional structures from OCA and Proteopedia for PPIA Gene

    Alternative splice isoforms for PPIA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPIA Gene

Post-translational modifications for PPIA Gene

  • Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition.
  • Ubiquitination at Lys 31, Lys 49, Lys 82, Lys 91, Lys 131, Lys 133, and Lys 155
  • Glycosylation at Asn 108
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PPIA (PPIA)

Domains & Families for PPIA Gene

Gene Families for PPIA Gene

Graphical View of Domain Structure for InterPro Entry

P62937

UniProtKB/Swiss-Prot:

PPIA_HUMAN :
  • Contains 1 PPIase cyclophilin-type domain.
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
Domain:
  • Contains 1 PPIase cyclophilin-type domain.
Family:
  • Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
genes like me logo Genes that share domains with PPIA: view

Function for PPIA Gene

Molecular function for PPIA Gene

GENATLAS Biochemistry:
cyclophilin A,major intracellular receptor for the immunosuppressive agent cyclosporine A,with intrinsic peptidyl-prolyl cis-trans isomerase activity
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Enzyme Numbers (IUBMB) for PPIA Gene

Gene Ontology (GO) - Molecular Function for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA 14993672
GO:0005515 protein binding IPI 12730686
GO:0042277 peptide binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046790 virion binding NAS 11250896
genes like me logo Genes that share ontologies with PPIA: view
genes like me logo Genes that share phenotypes with PPIA: view

Animal Models for PPIA Gene

MGI Knock Outs for PPIA:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PPIA

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPIA Gene

Localization for PPIA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPIA Gene

Cytoplasm. Secreted. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPIA Gene COMPARTMENTS Subcellular localization image for PPIA gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IDA 16780588
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with PPIA: view

Pathways & Interactions for PPIA Gene

genes like me logo Genes that share pathways with PPIA: view

Pathways by source for PPIA Gene

Gene Ontology (GO) - Biological Process for PPIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IDA 14993672
GO:0006278 RNA-dependent DNA biosynthetic process TAS --
GO:0006457 protein folding TAS 2179953
GO:0019058 viral life cycle TAS --
GO:0019061 uncoating of virus TAS --
genes like me logo Genes that share ontologies with PPIA: view

No data available for SIGNOR curated interactions for PPIA Gene

Drugs & Compounds for PPIA Gene

(13) Drugs for PPIA Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, inhibitor, Target Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0
L-Proline Approved Nutra Target, binder 0
(3r)-1-Acetyl-3-Methylpiperidine Experimental Pharma Target 0
(3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl- Experimental Pharma Target 0
Ethyl Oxo(Piperidin-1-Yl)Acetate Experimental Pharma Target 0

(3) Additional Compounds for PPIA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for PPIA Gene

Compound Action Cas Number
Cyclosporin A Immunosuppressive agent 59865-13-3
TMN 355 cyclophilin A inhibitor 1186372-20-2
genes like me logo Genes that share compounds with PPIA: view

Transcripts for PPIA Gene

Unigene Clusters for PPIA Gene

Peptidylprolyl isomerase A (cyclophilin A):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PPIA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPIA Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
SP1: -
SP2: -
SP3: - -
SP4: -

Relevant External Links for PPIA Gene

GeneLoc Exon Structure for
PPIA
ECgene alternative splicing isoforms for
PPIA

Expression for PPIA Gene

mRNA expression in normal human tissues for PPIA Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPIA Gene



Protein tissue co-expression partners for PPIA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPIA Gene:

PPIA

SOURCE GeneReport for Unigene cluster for PPIA Gene:

Hs.356331
genes like me logo Genes that share expression patterns with PPIA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPIA Gene

Orthologs for PPIA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPIA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100337215 34
  • 94.51 (n)
  • 97.56 (a)
PPIA 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPIA 34
  • 88.28 (n)
  • 95.86 (a)
PPIA 35
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppia 34
  • 92.48 (n)
  • 96.34 (a)
Ppia 16
Gm10123 35
  • 96 (a)
OneToMany
Gm5160 35
  • 85 (a)
OneToMany
Ppia 35
  • 96 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PPIA 34
  • 99.39 (n)
  • 100 (a)
PPIA 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppia 34
  • 92.68 (n)
  • 96.34 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 93 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves PPIA 34
  • 81.71 (n)
  • 90.85 (a)
PPIA 35
  • 90 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496569 34
  • 67.27 (n)
  • 72.12 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398630 34
zebrafish
(Danio rerio)
Actinopterygii ppiaa 34
  • 69.92 (n)
  • 73.78 (a)
wufd61c06 34
PPIA 35
  • 1 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7768 36
  • 74 (a)
Cyp1 36
  • 74 (a)
CG5071 35
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyp-3 36
  • 67 (a)
cyp-7 36
  • 64 (a)
cyp-8 36
  • 52 (a)
cyn-1 34
  • 65.43 (n)
  • 72.84 (a)
T22F3.12 35
  • 45 (a)
ManyToMany
Y17G9B.4 35
  • 22 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER156C 34
  • 63.96 (n)
  • 64.37 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04565g 34
  • 61.62 (n)
  • 63.03 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR3 34
  • 59.33 (n)
  • 65.41 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ROC2 34
  • 66.46 (n)
  • 73.33 (a)
soybean
(Glycine max)
eudicotyledons Gma.12280 34
rice
(Oryza sativa)
Liliopsida Os09g0571400 34
  • 66.05 (n)
  • 72.84 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2570 35
  • 5 (a)
OneToMany
Species where no ortholog for PPIA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPIA Gene

ENSEMBL:
Gene Tree for PPIA (if available)
TreeFam:
Gene Tree for PPIA (if available)

Paralogs for PPIA Gene

Pseudogenes.org Pseudogenes for PPIA Gene

genes like me logo Genes that share paralogs with PPIA: view

Variants for PPIA Gene

Sequence variations from dbSNP and Humsavar for PPIA Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2331170 -- 44,798,496(+) GACAG(C/T)GAGAC intron-variant
rs8177827 -- 44,799,341(+) TGTGT(A/G)TATAT intron-variant
rs8177828 -- 44,799,830(+) CCCAA(C/T)ACAAA reference, synonymous-codon
rs8177829 -- 44,801,594(+) GAGTT(-/AAG)TTTAT utr-variant-3-prime
rs8177830 -- 44,801,650(+) AAGAG(-/AG)TGTTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PPIA Gene

Variant ID Type Subtype PubMed ID
nsv830985 CNV loss 17160897
nsv970472 CNV duplication 23825009

Variation tolerance for PPIA Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPIA Gene

Human Gene Mutation Database (HGMD)
PPIA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPIA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPIA Gene

Disorders for PPIA Gene

MalaCards: The human disease database

(5) MalaCards diseases for PPIA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diffuse intrinsic pontine glioma
  • infiltrative brainstem glioma
in situ carcinoma
  • carcinoma in situ
nodular nonsuppurative panniculitis
  • nodular non-suppurative febrile panniculitis
hiv-1
  • aids, slow progression to
hepatitis c virus
  • hepatitic c virus
- elite association - COSMIC cancer census association via MalaCards
Search PPIA in MalaCards View complete list of genes associated with diseases

Relevant External Links for PPIA

Genetic Association Database (GAD)
PPIA
Human Genome Epidemiology (HuGE) Navigator
PPIA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPIA
genes like me logo Genes that share disorders with PPIA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPIA Gene

Publications for PPIA Gene

  1. Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS. (PMID: 17590083) An P. … Winkler C.A. (PLoS Pathog. 2007) 3 22 46 65
  2. Characterization of the human cyclophilin gene and of related processed pseudogenes. (PMID: 2197089) Haendler B. … Hofer E. (Eur. J. Biochem. 1990) 2 3 4 65
  3. EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation. (PMID: 19758589) Seizer P. … May A.E. (Atherosclerosis 2010) 3 22 65
  4. Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. (PMID: 20364129) Lammers M. … James L.C. (Nat. Chem. Biol. 2010) 3 4 65
  5. Cyclophilin A: potential functions and therapeutic target for human cancer. (PMID: 19865066) Obchoei S. … Chen C. (Med. Sci. Monit. 2009) 3 22 65

Products for PPIA Gene

Sources for PPIA Gene

Content