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PPFIBP2 Gene

protein-coding   GIFtS: 54
GCID: GC11P007491

PTPRF Interacting Protein, Binding Protein 2 (Liprin Beta...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PTPRF Interacting Protein, Binding Protein 2 (Liprin Beta 2)1 2
Protein Tyrosine Phosphatase Receptor Type F Polypeptide-Interacting
Protein-Binding Protein 22 3
Cclp12
liprin-beta-22
PTPRF-Interacting Protein-Binding Protein 23

External Ids:    HGNC: 92501   Entrez Gene: 84952   Ensembl: ENSG000001663877   OMIM: 6031425   UniProtKB: Q8ND303   

Export aliases for PPFIBP2 gene to outside databases

Previous GC identifers: GC11P008370 GC11P007995 GC11P007494 GC11P007499 GC11P007193


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPFIBP2 Gene:
This gene encodes a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. The
encoded protein is a beta liprin and plays a role in axon guidance and neuronal synapse development by recruiting
LAR protein-tyrosine phosphatases to the plasma membrane. Alternatively spliced transcript variants encoding
multiple isoforms have been observed for this gene. (provided by RefSeq, Feb 2012)

GeneCards Summary for PPFIBP2 Gene:
PPFIBP2 (PTPRF interacting protein, binding protein 2 (liprin beta 2)) is a protein-coding gene. GO annotations related to this gene include integrase activity. An important paralog of this gene is KAZN.

UniProtKB/Swiss-Prot: LIPB2_HUMAN, Q8ND30
Function: May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type
2A




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPFIBP2 gene promoter:
         Nkx3-1   ER-alpha   Sp1   Nkx3-1 v1   STAT5A   Nkx3-1 v2   POU2F1   POU2F1b   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPFIBP2 promoter sequence
   Search Chromatin IP Primers for PPFIBP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPFIBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

PPFIBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPFIBP2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P007491:  view genomic region     (about GC identifiers)

Start:
7,534,529 bp from pter      End:
7,678,358 bp from pter
Size:
143,830 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LIPB2_HUMAN, Q8ND30 (See protein sequence)
Recommended Name: Liprin-beta-2  
Size: 876 amino acids; 98544 Da
Subunit: Forms homodimers and heterodimers (By similarity)
1 PDB 3D structure from and Proteopedia for PPFIBP2:
3QH9 (3D)    
Secondary accessions: B7Z433 E9PK77 O75337 Q8WW26
Alternative splicing: 3 isoforms:  Q8ND30-1   Q8ND30-2   Q8ND30-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for PPFIBP2: NX_Q8ND30

Explore proteomics data for PPFIBP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPFIBP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243497.1  NP_001243498.1  NP_003612.2  

    ENSEMBL proteins: 
     ENSP00000434641   ENSP00000431724   ENSP00000299492   ENSP00000434981   ENSP00000433026  
     ENSP00000433917   ENSP00000435794   ENSP00000436498   ENSP00000433839   ENSP00000435469  
     ENSP00000437321   ENSP00000433713   ENSP00000436739   ENSP00000436489  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SAMD: Sterile alpha motif (SAM) domain containing

    5 InterPro protein domains:
     IPR021129 SAM_type1
     IPR004191 Integrase_Tn916-type_DNA-bd_N
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR011510 SAM_2

    Graphical View of Domain Structure for InterPro Entry Q8ND30

    ProtoNet protein and cluster: Q8ND30

    3 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB004191 Tn916 integrase
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: LIPB2_HUMAN, Q8ND30
    Domain: The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type
    beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha (By similarity)
    Similarity: Belongs to the liprin family. Liprin-beta subfamily
    Similarity: Contains 3 SAM (sterile alpha motif) domains


    Find genes that share domains with PPFIBP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIPB2_HUMAN, Q8ND30
    Function: May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type
    2A

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008907integrase activity IEA--
         
    Find genes that share ontologies with PPFIBP2           About GenesLikeMe


    Animal Models:
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    Selected qRT-PCR Assays for microRNAs that regulate PPFIBP2 (see all 16):
    hsa-miR-3910 hsa-miR-4318 hsa-miR-125a-3p hsa-miR-124 hsa-miR-506 hsa-miR-556-3p hsa-miR-642b hsa-miR-892a
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005622intracellular TAS9624153

    Find genes that share ontologies with PPFIBP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPFIBP2
    Interactions:

        Search GeneGlobe Interaction Network for PPFIBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for PPFIBP2 (Q8ND302, 3 ENSP000002994924) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSG101Q998162, 3, ENSP000002519684MINT-66433 I2D: score=5 STRING: ENSP00000251968
    SFNP319472, 3MINT-3975178 I2D: score=2 
    DTNBO609413, ENSP000003840844I2D: score=3 STRING: ENSP00000384084
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    PPFIA3O751453, ENSP000003356144I2D: score=1 STRING: ENSP00000335614
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007154cell communication ----
    GO:0015074DNA integration ----

    Find genes that share ontologies with PPFIBP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPFIBP2 (LIPB2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPFIBP2 gene (3 alternative transcripts): 
    NM_001256568.1  NM_001256569.1  NM_003621.3  

    Unigene Cluster for PPFIBP2:

    PTPRF interacting protein, binding protein 2 (liprin beta 2)
    Hs.655714  [show with all ESTs]
    Unigene Representative Sequence: NM_003621
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000526873 ENST00000528947 ENST00000299492(uc001mfj.4) ENST00000527790
    ENST00000526046 ENST00000524548 ENST00000529575 ENST00000533792(uc010rbd.1 uc010rbb.1 uc010rbc.2 uc010rbe.2)
    ENST00000532926(uc001mfk.1) ENST00000525597 ENST00000529021 ENST00000528883
    ENST00000529321 ENST00000530189 ENST00000530181(uc001mfl.4) ENST00000532416
    ENST00000534409 ENST00000530582(uc009yfj.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PPFIBP2 (see all 16):
    hsa-miR-3910 hsa-miR-4318 hsa-miR-125a-3p hsa-miR-124 hsa-miR-506 hsa-miR-556-3p hsa-miR-642b hsa-miR-892a
    SwitchGear 3'UTR luciferase reporter plasmidPPFIBP2 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat PPFIBP2
      QuantiFast Probe-based Assays in human, mouse, rat PPFIBP2

    Additional mRNA sequence: 

    AF034803.1 AK001131.1 AK025337.1 AK097449.1 AK293669.1 AK294554.1 AK296718.1 AK301978.1 
    AK308398.1 AK311048.1 AL834426.1 BC021026.1 BC021714.1 CR749258.1 

    18 DOTS entries:

    DT.452999  DT.100009989  DT.100787630  DT.100787632  DT.91650802  DT.95307781  DT.100787637  DT.425417 
    DT.120748187  DT.100809764  DT.120748153  DT.120748231  DT.120748192  DT.40190437  DT.75159030  DT.92027374 
    DT.120748173  DT.95195773 

    Selected AceView cDNA sequences (see all 205):

    BF726124 AI868399 AA583006 AI149790 CD109093 BU624376 AL834426 CB161350 
    AI692180 CB129260 CD364931 BX109147 AW576293 CA503137 BF726125 AI805241 
    CD171856 AA331841 AA877353 AI057485 BM682279 AA551750 AI685894 AW499968 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPFIBP2 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
    SP1:                                                                                                                                                  -         
    SP2:                    -     -     -                                   -                 -     -                                                               
    SP3:                          -     -                                   -                                                                                       
    SP4:                                                                                                                                                            
    SP5:                    -     -                                                                                                                                 

    ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31
    SP1:                                -                                   -                                 
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for PPFIBP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPFIBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACACTCCCA
    PPFIBP2 Expression
    About this image


    PPFIBP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Hippocampus
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced SM30 cells
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
    PPFIBP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPFIBP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655714

    UniProtKB/Swiss-Prot: LIPB2_HUMAN, Q8ND30
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PPFIBP2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppfibp21 , 5 PTPRF interacting protein, binding protein 2 (liprin more1, 5 87.54(n)1
    89.97(a)1
      7 (57.21 cM)5
    190241  NM_001163557.11  NP_001157029.11 
     1075950515 
    chicken
    (Gallus gallus)
    Aves PPFIBP21 PTPRF interacting protein, binding protein 2 (liprin more 70.47(n)
    70.93(a)
      428843  XM_004941355.1  XP_004941412.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPFIBP26
    PTPRF interacting protein, binding protein 2 (lipr...
    61(a)
    1 ↔ 1
    GL343237.1(1749878-1826999)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.253272 Xenopus laevis transcribed sequence with weak similarity more 74.31(n)    CF547250.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ppfibp2a1 protein tyrosine phosphatase, receptor-type, F interacting more 61.75(n)
    60.76(a)
      100317962  XM_005159197.1  XP_005159254.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG112063   -- 45(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea T21H8.13   -- 35(a)   X(13900765-13907968)   --


    ENSEMBL Gene Tree for PPFIBP2 (if available)
    TreeFam Gene Tree for PPFIBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPFIBP2 gene
    KAZN2  PPFIA22  PPFIBP12  PPFIA42  PPFIA32  PPFIA12  
    4 SIMAP similar genes for PPFIBP2 using alignment to 11 protein entries:     LIPB2_HUMAN (see all proteins):
    DKFZp781K06126    PPFIBP1-ALK    PPFIBP1    KIAA1026

    Find genes that share paralogs with PPFIBP2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PPFIBP2
    PGOHUM00000258667


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPFIBP2 (see all 3432)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1870090721,2
    --7191661(+) TATTAC/GCTGCC 1 -- us2k10--------
    rs1380343241,2
    --7191729(+) GGGGTA/GGATTT 1 -- us2k10--------
    rs1494984421,2
    --7191732(+) GTAGAC/TTTATC 1 -- us2k10--------
    rs43709121,2
    C,F,A,H--7191760(+) CAACCA/GTAGTT 1 -- us2k136Minor allele frequency- N:0.00NS EA NA WA CSA 3081
    rs770022121,2
    C,F--7191763(+) CCATAG/ATTCCT 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs1471957731,2
    --7191856(+) CACATA/CTGCCC 1 -- us2k10--------
    rs1911917701,2
    --7191958(+) GGACCA/GCTTTG 1 -- us2k10--------
    rs1825175241,2
    --7191983(+) GCGCAC/GGTCAG 1 -- us2k10--------
    rs1443298451,2
    --7192088(+) ATCAGC/TGGTTC 1 -- us2k10--------
    rs1473468061,2
    --7192110(+) TGCACA/GTAAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPFIBP2 (7534529 - 7678358 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PPFIBP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268850CNV Insertion20981092
    esv273993CNV Insertion20981092
    nsv7659CNV Loss18451855
    dgv58n21CNV Loss19592680
    nsv499766OTHER Inversion21111241
    nsv7215OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPFIBP2
    DNA2.0 Custom Variant and Variant Library Synthesis for PPFIBP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603142    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PPFIBP2:
    Cholangiocarcinoma

    Find genes that share disorders with PPFIBP2           About GenesLikeMe

    Genetic Association Database (GAD): PPFIBP2
    Human Genome Epidemiology (HuGE) Navigator: PPFIBP2 (2 documents)

    Export disorders for PPFIBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPFIBP2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with PPFIBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase- interacting proteins. (PubMed id 9624153)1, 2, 3 Serra-Pages C.... Streuli M. (J. Biol. Chem. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PubMed id 20095854)1, 4 Bhatti P....Sigurdson A.J. (Radiat. Res. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin- beta2. (PubMed id 22328529)1 von Thun A.... Norman J.C. (J. Cell Sci. 2012)
    7. Crystal structure of the central coiled-coil domain from human liprin-I^2. (PubMed id 21462929)1 Stafford R.L....Bowie J.U. (Biochemistry 2011)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Molecular markers of endometrial carcinoma detected in uterine aspirates. (PubMed id 21207424)1 Colas E....Gil-Moreno A. (Int. J. Cancer 2011)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8495 HGNC: 9250 AceView: PPFIBP2 Ensembl:ENSG00000166387 euGenes: HUgn8495
    ECgene: PPFIBP2 H-InvDB: PPFIBP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPFIBP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPFIBP2 gene:
    Search GeneIP for patents involving PPFIBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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