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Aliases for PPFIBP2 Gene

Aliases for PPFIBP2 Gene

  • PPFIA Binding Protein 2 2 3 5
  • Protein Tyrosine Phosphatase Receptor Type F Polypeptide-Interacting Protein-Binding Protein 2 3 4
  • PTPRF Interacting Protein, Binding Protein 2 (Liprin Beta 2) 2 3
  • Liprin Beta 2 2 3
  • PTPRF-Interacting Protein-Binding Protein 2 4
  • Liprin-Beta-2 3
  • Cclp1 3

External Ids for PPFIBP2 Gene

Previous GeneCards Identifiers for PPFIBP2 Gene

  • GC11P008370
  • GC11P007995
  • GC11P007494
  • GC11P007499
  • GC11P007193

Summaries for PPFIBP2 Gene

Entrez Gene Summary for PPFIBP2 Gene

  • This gene encodes a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. The encoded protein is a beta liprin and plays a role in axon guidance and neuronal synapse development by recruiting LAR protein-tyrosine phosphatases to the plasma membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for PPFIBP2 Gene

PPFIBP2 (PPFIA Binding Protein 2) is a Protein Coding gene. Diseases associated with PPFIBP2 include Bile Duct Adenocarcinoma. GO annotations related to this gene include integrase activity. An important paralog of this gene is PPFIBP1.

UniProtKB/Swiss-Prot for PPFIBP2 Gene

  • May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPFIBP2 Gene

Genomics for PPFIBP2 Gene

Regulatory Elements for PPFIBP2 Gene

Enhancers for PPFIBP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PPFIBP2 on UCSC Golden Path with GeneCards custom track

Promoters for PPFIBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PPFIBP2 Gene

Chromosome:
11
Start:
7,513,298 bp from pter
End:
7,667,344 bp from pter
Size:
154,047 bases
Orientation:
Plus strand

Genomic View for PPFIBP2 Gene

Genes around PPFIBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPFIBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPFIBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPFIBP2 Gene

Proteins for PPFIBP2 Gene

  • Protein details for PPFIBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND30-LIPB2_HUMAN
    Recommended name:
    Liprin-beta-2
    Protein Accession:
    Q8ND30
    Secondary Accessions:
    • B7Z433
    • E9PK77
    • O75337
    • Q8WW26

    Protein attributes for PPFIBP2 Gene

    Size:
    876 amino acids
    Molecular mass:
    98544 Da
    Quaternary structure:
    • Forms homodimers and heterodimers.

    Three dimensional structures from OCA and Proteopedia for PPFIBP2 Gene

    Alternative splice isoforms for PPFIBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPFIBP2 Gene

Post-translational modifications for PPFIBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPFIBP2 Gene

Domains & Families for PPFIBP2 Gene

Gene Families for PPFIBP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8ND30

UniProtKB/Swiss-Prot:

LIPB2_HUMAN :
  • The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha (By similarity).
  • Belongs to the liprin family. Liprin-beta subfamily.
Domain:
  • The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha (By similarity).
  • Contains 3 SAM (sterile alpha motif) domains.
Family:
  • Belongs to the liprin family. Liprin-beta subfamily.
genes like me logo Genes that share domains with PPFIBP2: view

Function for PPFIBP2 Gene

Molecular function for PPFIBP2 Gene

UniProtKB/Swiss-Prot Function:
May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.

Gene Ontology (GO) - Molecular Function for PPFIBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with PPFIBP2: view
genes like me logo Genes that share phenotypes with PPFIBP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PPFIBP2 Gene

Localization for PPFIBP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPFIBP2 Gene COMPARTMENTS Subcellular localization image for PPFIBP2 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PPFIBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005622 intracellular TAS 9624153
genes like me logo Genes that share ontologies with PPFIBP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPFIBP2 Gene

Pathways & Interactions for PPFIBP2 Gene

SuperPathways for PPFIBP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPFIBP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PPFIBP2 Gene

Drugs & Compounds for PPFIBP2 Gene

No Compound Related Data Available

Transcripts for PPFIBP2 Gene

Unigene Clusters for PPFIBP2 Gene

PTPRF interacting protein, binding protein 2 (liprin beta 2):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPFIBP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1: -
SP2: - - - - - -
SP3: - - -
SP4:
SP5: - -
SP6:
SP7: - - - - -
SP8: -
SP9: - - -
SP10:
SP11:
SP12:

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for PPFIBP2 Gene

GeneLoc Exon Structure for
PPFIBP2
ECgene alternative splicing isoforms for
PPFIBP2

Expression for PPFIBP2 Gene

mRNA expression in normal human tissues for PPFIBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPFIBP2 Gene

This gene is overexpressed in Liver (11.3) and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPFIBP2 Gene



Protein tissue co-expression partners for PPFIBP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PPFIBP2 Gene:

PPFIBP2

SOURCE GeneReport for Unigene cluster for PPFIBP2 Gene:

Hs.655714

mRNA Expression by UniProt/SwissProt for PPFIBP2 Gene:

Q8ND30-LIPB2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with PPFIBP2: view

Primer Products

No data available for mRNA differential expression in normal tissues for PPFIBP2 Gene

Orthologs for PPFIBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPFIBP2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PPFIBP2 34
  • 87.44 (n)
  • 87.9 (a)
PPFIBP2 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppfibp2 34
  • 87.54 (n)
  • 89.97 (a)
Ppfibp2 16
Ppfibp2 35
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPFIBP2 34
  • 99.39 (n)
  • 99.32 (a)
PPFIBP2 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppfibp2 34
  • 87.85 (n)
  • 90.29 (a)
cow
(Bos Taurus)
Mammalia PPFIBP2 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPFIBP2 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPFIBP2 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPFIBP2 34
  • 70.47 (n)
  • 70.93 (a)
PPFIBP2 35
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPFIBP2 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppfibp2 34
  • 64.07 (n)
  • 62.33 (a)
Str.14980 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25327 34
zebrafish
(Danio rerio)
Actinopterygii ppfibp2a 34
  • 61.75 (n)
  • 60.76 (a)
ppfibp2a 35
  • 53 (a)
OneToMany
ppfibp2b 35
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10743 36
  • 38 (a)
CG11206 36
  • 45 (a)
Liprin-beta 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T21H8.1 36
  • 35 (a)
hlb-1 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for PPFIBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPFIBP2 Gene

ENSEMBL:
Gene Tree for PPFIBP2 (if available)
TreeFam:
Gene Tree for PPFIBP2 (if available)

Paralogs for PPFIBP2 Gene

Paralogs for PPFIBP2 Gene

Pseudogenes.org Pseudogenes for PPFIBP2 Gene

genes like me logo Genes that share paralogs with PPFIBP2: view

Variants for PPFIBP2 Gene

Sequence variations from dbSNP and Humsavar for PPFIBP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs4758209 - 7,649,209(+) TTGAC(A/G)GACGA nc-transcript-variant, reference, missense
rs1128012 -- 7,653,170(+) CCCCT(G/T)GATGC downstream-variant-500B, reference, synonymous-codon
rs7942561 -- 7,663,890(+) tattc(G/T)ggtgg intron-variant
rs7942568 -- 7,545,899(+) tacct(C/T)gggga intron-variant
rs7942673 -- 7,663,992(+) tgcct(C/T)gccct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPFIBP2 Gene

Variant ID Type Subtype PubMed ID
dgv1057n100 CNV gain 25217958
dgv58n21 CNV loss 19592680
esv3579335 CNV loss 25503493
esv3625293 CNV gain 21293372
esv3625294 CNV gain 21293372
esv3625296 CNV gain 21293372
esv3891925 CNV gain 25118596
nsv1035575 CNV gain 25217958
nsv1040844 CNV gain 25217958
nsv1129359 OTHER inversion 24896259
nsv499766 OTHER inversion 21111241
nsv553406 CNV loss 21841781
nsv7215 OTHER inversion 18451855
nsv7659 CNV deletion 18451855

Variation tolerance for PPFIBP2 Gene

Residual Variation Intolerance Score: 14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.89; 83.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPFIBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPFIBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPFIBP2 Gene

Disorders for PPFIBP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPFIBP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bile duct adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPFIBP2

Genetic Association Database (GAD)
PPFIBP2
Human Genome Epidemiology (HuGE) Navigator
PPFIBP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPFIBP2
genes like me logo Genes that share disorders with PPFIBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPFIBP2 Gene

Publications for PPFIBP2 Gene

  1. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase- interacting proteins. (PMID: 9624153) Serra-Pages C. … Streuli M. (J. Biol. Chem. 1998) 2 3 4 65
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  3. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PMID: 20095854) Bhatti P. … Sigurdson A.J. (Radiat. Res. 2010) 3 46 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for PPFIBP2 Gene

Sources for PPFIBP2 Gene

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