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Aliases for PPFIA3 Gene

Aliases for PPFIA3 Gene

  • PTPRF Interacting Protein Alpha 3 2 3
  • Protein Tyrosine Phosphatase, Receptor Type, F Polypeptide (PTPRF), Interacting Protein (Liprin), Alpha 3 2 3 5
  • Protein Tyrosine Phosphatase Receptor Type F Polypeptide-Interacting Protein Alpha-3 3 4
  • PTPRF-Interacting Protein Alpha-3 3 4
  • Liprin-Alpha 3 2 3
  • Protein Tyrosine Phosphatase, Receptor Type, F Polypeptide, Alpha 3 3
  • Protein Tyrosine Phosphatase 2
  • Receptor Type 2
  • F Polypeptide 2
  • KIAA0654 4
  • Alpha 3 2
  • LIPRIN 3
  • Liprin 2
  • LPNA3 3

External Ids for PPFIA3 Gene

Previous GeneCards Identifiers for PPFIA3 Gene

  • GC19P050280
  • GC19P049990
  • GC19P054299
  • GC19P054314
  • GC19P049622
  • GC19P045998

Summaries for PPFIA3 Gene

Entrez Gene Summary for PPFIA3 Gene

  • The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. Liprin family protein has been shown to localize phosphatase LAR to cell focal adhesions and may be involved in the molecular organization of presynaptic active zones. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPFIA3 Gene

PPFIA3 (PTPRF Interacting Protein Alpha 3) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Neurotransmitter Release Cycle. An important paralog of this gene is KAZN.

UniProtKB/Swiss-Prot for PPFIA3 Gene

  • May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPFIA3 Gene

Genomics for PPFIA3 Gene

Regulatory Elements for PPFIA3 Gene

Enhancers for PPFIA3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPFIA3 on UCSC Golden Path with GeneCards custom track

Promoters for PPFIA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPFIA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PPFIA3 Gene

Chromosome:
19
Start:
49,119,389 bp from pter
End:
49,151,030 bp from pter
Size:
31,642 bases
Orientation:
Plus strand

Genomic View for PPFIA3 Gene

Genes around PPFIA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPFIA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPFIA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPFIA3 Gene

Proteins for PPFIA3 Gene

  • Protein details for PPFIA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75145-LIPA3_HUMAN
    Recommended name:
    Liprin-alpha-3
    Protein Accession:
    O75145
    Secondary Accessions:
    • A8K142
    • Q3MJA0
    • Q9H8B5
    • Q9UEW4

    Protein attributes for PPFIA3 Gene

    Size:
    1194 amino acids
    Molecular mass:
    133496 Da
    Quaternary structure:
    • Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Binds RIMS1, RIMS2, RIMS3 and RIMS4 (By similarity).
    SequenceCaution:
    • Sequence=BAA31629.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PPFIA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPFIA3 Gene

Proteomics data for PPFIA3 Gene at MOPED

Post-translational modifications for PPFIA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPFIA3 Gene

No data available for DME Specific Peptides for PPFIA3 Gene

Domains & Families for PPFIA3 Gene

Gene Families for PPFIA3 Gene

Protein Domains for PPFIA3 Gene

Graphical View of Domain Structure for InterPro Entry

O75145

UniProtKB/Swiss-Prot:

LIPA3_HUMAN :
  • The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.
  • Belongs to the liprin family. Liprin-alpha subfamily.
Domain:
  • The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.
  • Contains 3 SAM (sterile alpha motif) domains.
Family:
  • Belongs to the liprin family. Liprin-alpha subfamily.
genes like me logo Genes that share domains with PPFIA3: view

Function for PPFIA3 Gene

Molecular function for PPFIA3 Gene

GENATLAS Biochemistry:
protein tyrosine phosphatase, receptor type,f polypeptide (PTPRF),interacting protein (liprin),alpha 3,expressed in brain,>100kDa,related to LAR-interacting protein LIP1B
UniProtKB/Swiss-Prot Function:
May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
genes like me logo Genes that share phenotypes with PPFIA3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPFIA3 Gene

Localization for PPFIA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPFIA3 Gene

Cytoplasm. Cell surface. Note=Colocalizes with PTPRF at the cell surface. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPFIA3 Gene COMPARTMENTS Subcellular localization image for PPFIA3 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPFIA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048786 presynaptic active zone IEA,TAS 15217342
genes like me logo Genes that share ontologies with PPFIA3: view

Pathways & Interactions for PPFIA3 Gene

genes like me logo Genes that share pathways with PPFIA3: view

Gene Ontology (GO) - Biological Process for PPFIA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion IEA,TAS --
genes like me logo Genes that share ontologies with PPFIA3: view

No data available for SIGNOR curated interactions for PPFIA3 Gene

Drugs & Compounds for PPFIA3 Gene

No Compound Related Data Available

Transcripts for PPFIA3 Gene

mRNA/cDNA for PPFIA3 Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPFIA3 Gene

Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPFIA3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9: -
SP10:
SP11: -
SP12: - - -
SP13:
SP14: - -
SP15:

ExUns: 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c
SP1: - -
SP2: - - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for PPFIA3 Gene

GeneLoc Exon Structure for
PPFIA3
ECgene alternative splicing isoforms for
PPFIA3

Expression for PPFIA3 Gene

mRNA expression in normal human tissues for PPFIA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPFIA3 Gene

This gene is overexpressed in Brain - Cortex (x4.9), Pituitary (x4.2), and Brain - Frontal Cortex (BA9) (x4.0).

Protein differential expression in normal tissues from HIPED for PPFIA3 Gene

This gene is overexpressed in Brain (28.4), Frontal cortex (21.3), and Fetal Brain (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPFIA3 Gene



SOURCE GeneReport for Unigene cluster for PPFIA3 Gene Hs.413748

mRNA Expression by UniProt/SwissProt for PPFIA3 Gene

O75145-LIPA3_HUMAN
Tissue specificity: Expressed only in brain.
genes like me logo Genes that share expression patterns with PPFIA3: view

Protein tissue co-expression partners for PPFIA3 Gene

- Elite partner

Primer Products

Orthologs for PPFIA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPFIA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPFIA3 35
  • 92.77 (n)
  • 99.16 (a)
PPFIA3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPFIA3 35
  • 92.45 (n)
  • 98.07 (a)
PPFIA3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppfia3 35
  • 89.17 (n)
  • 98.07 (a)
Ppfia3 16
Ppfia3 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPFIA3 35
  • 96.43 (n)
  • 96.09 (a)
PPFIA3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppfia3 35
  • 88.62 (n)
  • 98.07 (a)
oppossum
(Monodelphis domestica)
Mammalia PPFIA3 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPFIA3 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPFIA3 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppfia3 35
  • 72.08 (n)
  • 82.38 (a)
zebrafish
(Danio rerio)
Actinopterygii ppfia3 35
  • 70.65 (n)
  • 79.08 (a)
ppfia3 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11206 37
  • 38 (a)
Liprin-alpha 36
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea syd-2 37
  • 43 (a)
syd-2 36
  • 45 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for PPFIA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPFIA3 Gene

ENSEMBL:
Gene Tree for PPFIA3 (if available)
TreeFam:
Gene Tree for PPFIA3 (if available)

Paralogs for PPFIA3 Gene

Paralogs for PPFIA3 Gene

(4) SIMAP similar genes for PPFIA3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PPFIA3: view

Variants for PPFIA3 Gene

Sequence variations from dbSNP and Humsavar for PPFIA3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2303053 - 49,136,745(+) CCCCT(G/T)CGGGC nc-transcript-variant, reference, missense
rs7256715 -- 49,137,360(+) GCTCA(C/T)GCCTG intron-variant
rs7256909 -- 49,126,589(+) ttCCC(A/G)AATGG intron-variant, upstream-variant-2KB
rs7259991 -- 49,137,578(+) TGAGC(C/T)GAGAT intron-variant
rs12979213 -- 49,126,732(+) CCTGG(G/T)TCCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPFIA3 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833857 CNV Loss 17160897
dgv3970n71 CNV Loss 21882294
nsv833859 CNV Loss 17160897
nsv912252 CNV Loss 21882294
nsv912254 CNV Loss 21882294
nsv912255 CNV Loss 21882294
nsv912258 CNV Loss 21882294
dgv3971n71 CNV Loss 21882294
nsv819445 CNV Gain 19587683
nsv470149 CNV Loss 18288195
nsv524235 CNV Gain 19592680

Variation tolerance for PPFIA3 Gene

Residual Variation Intolerance Score: 2.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.73; 91.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PPFIA3 Gene

Disorders for PPFIA3 Gene

Relevant External Links for PPFIA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPFIA3

No disorders were found for PPFIA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPFIA3 Gene

Publications for PPFIA3 Gene

  1. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase- interacting proteins. (PMID: 9624153) Serra-Pages C. … Streuli M. (J. Biol. Chem. 1998) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3

Products for PPFIA3 Gene

Sources for PPFIA3 Gene

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