 |
 | Services
| |
 |
Aliases & Descriptions for PPFIA2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ41378 2 | | MGC132572 2 |
| | | Descriptions |
|---|
| PTPRF interacting protein alpha 2 2 | | PTPRF-interacting protein alpha-2 3 | Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2 3 | | liprin-alpha 2 2 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 2 |
|
| | Search outside databases for aliases for PPFIA2 genePrevious GC identifers: GC12M084491 GC12M082017 GC12M081584 |
Summaries for PPFIA2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for PPFIA2: The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein is most closely related to PPFIA1, a liprin family member known to interact with the protein phosphatase LAR. The expression of this gene is found to be downregulated by androgens in a prostate cancer cell line. [provided by RefSeq] UniProtKB/Swiss-Prot: LIPA2_HUMAN, O75334Function: Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates |
Genomic Location for PPFIA2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the PPFIA2 gene 
Entrez Gene cytogenetic band: 12q21.31 Ensembl cytogenetic band: 12q21.31 HGNC cytogenetic band: 12q21.31PPFIA2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M080155:
(about GC identifiers)
Start:
|
80,177,487 bp from pter |
End:
|
80,677,240 bp from pter |
Size:
|
499,754 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000012.10 NT_019546.15
| Proteins for PPFIA2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LIPA2_HUMAN, O75334 (See
protein sequence)Recommended Name: Liprin-alpha-2 Size: 1257 amino acids; 143142 Da
Subunit: Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS
Subcellular location: Cytoplasm. Cell surface. Note=Colocalizes with PTPRF at the cell surfacePost-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003616.2
ENSEMBL proteins: ENSP00000327416 ENSP00000385093
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for PPFIA2: Assays for PPFIA2: | Protein
Domains/ Families for PPFIA2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O75334
ProtoNet protein and cluster: O75334 2 Blocks protein families: IPB001660 Sterile alpha motif SAM IPB011510 Sterile alpha motif homology 2
UniProtKB/Swiss-Prot: LIPA2_HUMAN, O75334Domain: The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRSSimilarity: Belongs to the liprin family. Liprin-alpha subfamilySimilarity: Contains 3 SAM (sterile alpha motif) domains | Gene Function for PPFIA2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003625
Applied Biosystems Silencer® siRNAs for PPFIA2
Sigma-Aldrich siRNA and siRNA Panels for PPFIA2  Sigma-Aldrich shRNA Panels and shRNA for PPFIA2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003625                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003625                                  untagged cDNA clone in CMV expression vector: NM_003625 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003625
UniProtKB/Swiss-Prot: LIPA2_HUMAN, O75334Function: Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for PPFIA2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/7 Interacting proteins for PPFIA2 (ENSP000003274163) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for PPFIA2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for PPFIA2
|
Transcripts for PPFIA2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003625
Sigma-Aldrich siRNA and siRNA Panels for PPFIA2  Sigma-Aldrich shRNA Panels and shRNA for PPFIA2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003625 REFSEQ mRNAs for PPFIA2 gene: NM_003625.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003625               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003625                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003625                                  untagged cDNA clone in CMV expression vector: NM_003625  Additional cDNA sequence: AB210009.1 AF034799.1 AK123372.1 AK126971.1 AK294505.1 AK296380.1 AK297372.1 AK299853.1 AK302658.1 AK307524.1 AL157453.1 BC104912.1 BC143485.1 11 DOTS entries: DT.97792131 DT.409054 DT.100008354 DT.107168 DT.101981713 DT.121182319 DT.121182285 DT.121182277 DT.40210520 DT.97800233 DT.97807395 24/33 AceView cDNA sequences (see all 33
):BQ027545 AK126971 BM689808 NM_003625 BM661844 AK123372 AL157453 BU153957 BU568524 CB051855 BX951956 BQ008801 N45544 AL712783 AF034799 BF002886 BX507846 AW014561 BM545514 BQ340238 BM718222 N51002 AL713132 BF525425
highest scoring ESTs for PPFIA2:AF034799 AK126971 N48694 AA021459 AA885753 AB210009 AI002917 AL712783 AW014561 BF002886 Unigene Cluster for PPFIA2: Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 Hs.506216 [show with all ESTs]Unigene Representative Sequence: AB210009
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000333447
ENST00000407050
|
Expression for PPFIA2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PPFIA2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PPFIA2
1 / 2 / 3 7 probe-sets matching PPFIA2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.506216
Expression variation in blood from EXPOLDB for PPFIA2 UniProtKB/Swiss-Prot: LIPA2_HUMAN, O75334Tissue specificity: Expressed only in brain |
Orthologs for PPFIA2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PPFIA2 gene from 5/10 species (see all 10
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
PPFIA21 |
-- |
protein tyrosine phosphatase, receptor type, f polypeptide more |
93.2(n) 98.43(a) |
475415 XM_532638.2 XP_532638.2 |
chimpanzee (Pan troglodytes) |
PPFIA21 |
-- |
protein tyrosine phosphatase, receptor type, f polypeptide more |
99.79(n) 100(a) |
452101 XM_509243.2 XP_509243.2 |
rat (Rattus norvegicus) |
Ppfia21 |
-- |
protein tyrosine phosphatase, receptor type, f polypeptide more |
90.29(n) 98.97(a) |
362876 XM_343204.3 XP_343205.3 |
mouse (Mus musculus) |
Ppfia21, 5 |
105
|
protein tyrosine phosphatase, receptor type, f polypeptide more1, 5 |
90.53(n)1 98.81(a)1 |
3278141 NM_177373.31 NP_796347.21 AC1110145 AI8542255 (see all 11) |
chicken (Gallus gallus) |
PPFIA21 |
-- |
protein tyrosine phosphatase, receptor type, f polypeptide more |
84.03(n) 95.66(a) |
417877 XM_416120.2 XP_416120.2 |
About this table Species with no ortholog for PPFIA2
ENSEMBL Gene Tree for PPFIA2 | Paralogs for PPFIA2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for PPFIA2 gene
- PPFIA42 PPFIA32 PPFIA12
|
SNPs/Variants for PPFIA2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PPFIA2 (up to first 250kb)
|
Disorders & Mutations for PPFIA2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603143
|
Medical News for PPFIA2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for PPFIA2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for PPFIA2 gene: |
Search for PPFIA2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PPFIA2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PPFIA2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PPFIA2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for PPFIA2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for PPFIA2:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for PPFIA2 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|