Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PPFIA2 Gene

protein-coding   GIFtS: 53
GCID: GC12M081584

Protein Tyrosine Phosphatase, Receptor Type, F Polypeptide...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Protein Tyrosine Phosphatase, Receptor Type, F Polypeptide (PTPRF),
Interacting Protein (Liprin), Alpha 21 2
Liprin-alpha21
liprin-alpha-22
Protein Tyrosine Phosphatase Receptor Type F Polypeptide-Interacting
Protein Alpha-23
PTPRF-Interacting Protein Alpha-23

External Ids:    HGNC: 92461   Entrez Gene: 84992   Ensembl: ENSG000001392207   OMIM: 6031435   UniProtKB: O753343   

Export aliases for PPFIA2 gene to outside databases

Previous GC identifers: GC12M084491 GC12M082017 GC12M080155 GC12M078710


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PPFIA2 Gene:
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin)
family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are
known to be important for axon guidance and mammary gland development. It has been proposed that liprins are
multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR
family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine
protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions
in mammals. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Sep 2013)

GeneCards Summary for PPFIA2 Gene:
PPFIA2 (protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2) is a protein-coding gene. Diseases associated with PPFIA2 include cerebral cavernous malformations 3, and cavernous malformation. An important paralog of this gene is KAZN.

UniProtKB/Swiss-Prot: LIPA2_HUMAN, O75334
Function: Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal
adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane,
possibly regulating their interaction with the extracellular environment and their association with substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPFIA2 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   Nkx2-5   LCR-F1   CREB   deltaCREB   AP-2alpha isoform 4   ZIC2/Zic2   AP-2alpha   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPFIA2 promoter sequence
   Search Chromatin IP Primers for PPFIA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPFIA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.31   Ensembl cytogenetic band:  12q21.31   HGNC cytogenetic band: 12q21.31

PPFIA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPFIA2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M081584:  view genomic region     (about GC identifiers)

Start:
81,652,045 bp from pter      End:
82,153,332 bp from pter
Size:
501,288 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LIPA2_HUMAN, O75334 (See protein sequence)
Recommended Name: Liprin-alpha-2  
Size: 1257 amino acids; 143291 Da
Subunit: Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase
domain of PTPRD, PTPRF and PTPRS
2 PDB 3D structures from and Proteopedia for PPFIA2:
3TAC (3D)        3TAD (3D)    
Secondary accessions: B3KVT5 B3KXA0 B7Z2A6 B7Z3U9 B7Z663 B7ZKZ5 E7ERB8 E7ETG6 F8VP68 Q2M3G8
Alternative splicing: 8 isoforms:  O75334-1   O75334-2   O75334-3   O75334-4   O75334-5   O75334-6   O75334-7   O75334-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPFIA2: NX_O75334

Explore proteomics data for PPFIA2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPFIA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (10 alternative transcripts): 
    NP_001207402.1  NP_001207403.1  NP_001207404.1  NP_001207405.1  NP_001207406.1  NP_001207407.1  NP_001207408.1  NP_001207409.1  
    NP_001269465.1  NP_003616.2  

    ENSEMBL proteins: 
     ENSP00000450337   ENSP00000449558   ENSP00000450298   ENSP00000438337   ENSP00000449821  
     ENSP00000447273   ENSP00000385093   ENSP00000449338   ENSP00000388373   ENSP00000447868  
     ENSP00000447189   ENSP00000449524   ENSP00000448941   ENSP00000447792   ENSP00000446555  
     ENSP00000449469   ENSP00000447918   ENSP00000327416   ENSP00000445532  

    PPFIA2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PPFIA2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PPFIA2
    GenScript Custom Purified and Recombinant Proteins Services for PPFIA2
    Novus Biologicals PPFIA2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PPFIA2

    PPFIA2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PPFIA2
    Novus Biologicals PPFIA2 Antibodies
    Abcam antibodies for PPFIA2
    Cloud-Clone Corp. Antibodies for PPFIA2
    ThermoFisher Antibodies for PPFIA2
    LSBio Antibodies in human, mouse, rat for PPFIA2

    PPFIA2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PPFIA2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPFIA2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PPFIA2
    Cloud-Clone Corp. CLIAs for PPFIA2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SAMD: Sterile alpha motif (SAM) domain containing

    4 InterPro protein domains:
     IPR021129 SAM_type1
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR011510 SAM_2

    Graphical View of Domain Structure for InterPro Entry O75334

    ProtoNet protein and cluster: O75334

    2 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: LIPA2_HUMAN, O75334
    Domain: The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type
    alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction
    with PTPRD, PTPRF and PTPRS
    Similarity: Belongs to the liprin family. Liprin-alpha subfamily
    Similarity: Contains 3 SAM (sterile alpha motif) domains


    PPFIA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIPA2_HUMAN, O75334
    Function: Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal
    adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane,
    possibly regulating their interaction with the extracellular environment and their association with substrates

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005515protein binding IPI12923177
         
    PPFIA2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PPFIA2:
     Decreased cilium length after   Decreased viability  Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPFIA2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPFIA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPFIA2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPFIA2

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPFIA2:
    hsa-mir-335-5p (MIRT018789)

    Block miRNA regulation of human, mouse, rat PPFIA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPFIA2 (see all 48):
    hsa-miR-21* hsa-miR-3607-3p hsa-miR-15a hsa-miR-128 hsa-miR-30d hsa-miR-301a hsa-miR-507 hsa-miR-424
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPFIA2
    Predesigned siRNA for gene silencing in human, mouse, rat PPFIA2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPFIA2

    Clone
    Products:
         
    OriGene clones in human, mouse for PPFIA2 (see all 7)
    OriGene ORF clones in mouse, rat for PPFIA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPFIA2 (NM_003625)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPFIA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPFIA2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PPFIA2
    Browse ESI BIO Cell Lines and PureStem Progenitors for PPFIA2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPFIA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LIPA2_HUMAN, O75334: Cytoplasm. Cell surface. Note=Colocalizes with PTPRF at the cell surface
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0009986cell surface IEA--
    GO:0045202synapse IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    PPFIA2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPFIA2
    Interactions:

        Search GeneGlobe Interaction Network for PPFIA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPFIA2 (O753343 ENSP000003883734) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERC2O150833, ENSP000002882214I2D: score=3 STRING: ENSP00000288221
    GIT1Q9Y2X73, ENSP000003783384I2D: score=3 STRING: ENSP00000378338
    PPP2R1AP301533, ENSP000003248044I2D: score=2 STRING: ENSP00000324804
    PTPRSQ133323, ENSP000003499324I2D: score=2 STRING: ENSP00000349932
    CASKO149363, ENSP000003674084I2D: score=1 STRING: ENSP00000367408
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007160cell-matrix adhesion TAS9624153

    PPFIA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPFIA2 (LIPA2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PPFIA2 gene (10 alternative transcripts): 
    NM_001220473.2  NM_001220474.2  NM_001220475.2  NM_001220476.2  NM_001220477.2  NM_001220478.2  NM_001220479.2  NM_001220480.2  
    NM_001282536.1  NM_003625.4  

    Unigene Cluster for PPFIA2:

    Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
    Hs.506216  [show with all ESTs]
    Unigene Representative Sequence: NM_001220473
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000549396(uc021rbf.1 uc010sug.2 uc021rbg.1 uc021rbh.1 uc021rbi.1 uc021rbj.1 uc001szo.2)
    ENST00000550584(uc021rbe.1 uc021rbk.1 uc021rbl.1) ENST00000549325
    ENST00000545296(uc010sue.2) ENST00000541570 ENST00000551461 ENST00000550359
    ENST00000407050 ENST00000548586 ENST00000443686 ENST00000552948 ENST00000550018
    ENST00000551147 ENST00000547180 ENST00000549344 ENST00000549917 ENST00000553058
    ENST00000548670
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PPFIA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPFIA2 (see all 48):
    hsa-miR-21* hsa-miR-3607-3p hsa-miR-15a hsa-miR-128 hsa-miR-30d hsa-miR-301a hsa-miR-507 hsa-miR-424
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PPFIA2
    Predesigned siRNA for gene silencing in human, mouse, rat PPFIA2
    Clone
    Products:
         
    OriGene clones in human, mouse for PPFIA2 (see all 7)
    OriGene ORF clones in mouse, rat for PPFIA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPFIA2 (NM_003625)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPFIA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPFIA2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PPFIA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPFIA2
      QuantiTect SYBR Green Assays in human, mouse, rat PPFIA2
      QuantiFast Probe-based Assays in human, mouse, rat PPFIA2

    Additional mRNA sequence: 

    AB210009.1 AF034799.1 AK123372.1 AK126971.1 AK294505.1 AK296380.1 AK297372.1 AK299853.1 
    AK302658.1 AK307524.1 AL157453.1 BC104912.1 BC143485.1 NR_038265.1 

    11 DOTS entries:

    DT.97792131  DT.409054  DT.100008354  DT.101981713  DT.107168  DT.121182285  DT.121182319  DT.121182277 
    DT.97800233  DT.97807395  DT.40210520 

    Selected AceView cDNA sequences (see all 33):

    BM689808 AK126971 NM_003625 AL157453 AK123372 BQ027545 BM661844 BX507846 
    AF034799 BU153957 CB051855 BU568524 AL712783 AW014561 BX951956 BF002886 
    BQ008801 N45544 BM545514 AL713132 BQ340238 BM718222 N51002 N48694 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PPFIA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PPFIA2 Expression
    About this image

    PPFIA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPFIA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.506216

    UniProtKB/Swiss-Prot: LIPA2_HUMAN, O75334
    Tissue specificity: Expressed only in brain

        Custom PCR Arrays for PPFIA2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PPFIA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPFIA2
    QuantiTect SYBR Green Assays in human, mouse, rat PPFIA2
    QuantiFast Probe-based Assays in human, mouse, rat PPFIA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPFIA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for PPFIA2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppfia21 , 5 protein tyrosine phosphatase, receptor type, f polypeptide more1, 5 90.51(n)1
    98.81(a)1
      10 (55.39 cM)5
    3278141  NM_001205341.11  NP_001192270.11 
     1064703105 
    chicken
    (Gallus gallus)
    Aves PPFIA21 protein tyrosine phosphatase, receptor type, f polypeptide more 83.77(n)
    95.1(a)
      417877  XM_416120.4  XP_416120.4 
    lizard
    (Anolis carolinensis)
    Reptilia PPFIA26
    protein tyrosine phosphatase, receptor type, f pol...
    90(a)
    1 ↔ 1
    5(36500401-36843480)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ppfia21 protein tyrosine phosphatase, receptor type, f polypeptide more 80.37(n)
    93.13(a)
      100489336  XM_002931621.2  XP_002931667.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ppfia21 protein tyrosine phosphatase, receptor type, f polypeptide more 72.89(n)
    87.03(a)
      566597  NM_001045111.1  NP_001038576.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG112063
    Liprin-alpha1
    Liprin-alpha1 34(a)3
    53.99(n)1
    58.1(a)1
      2490721  NM_001273226.11  NP_001260155.11 
    worm
    (Caenorhabditis elegans)
    Secernentea syd-21 , 3 liprin-alpha3
    syd-21
    44(a)3
    53.89(n)1
    52.39(a)1
      X(10584742-10590168)3
    1812551  NM_077367.61  NP_509768.11 


    ENSEMBL Gene Tree for PPFIA2 (if available)
    TreeFam Gene Tree for PPFIA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PPFIA2 gene
    KAZN2  PPFIBP12  PPFIA42  PPFIA32  PPFIA12  PPFIBP22  
    6 SIMAP similar genes for PPFIA2 using alignment to 12 protein entries:     LIPA2_HUMAN (see all proteins):
    PPFIA2 variant protein    PPFIA1    PPFIA4    PPFIA3    PPFIBP1    KAZN

    PPFIA2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PPFIA2
    PGOHUM00000261317


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PPFIA2 (see all 8743)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs719268051,2
    C--78831498(+) AGTGC-/TGTGT 
     GTGTGTG
    TGTGT
    8 -- int10--------
    rs128194421,2
    C,F,H--78964687(+) AAATAA/GTGACA 1 -- us2k118Minor allele frequency- G:0.35NA NS EA WA CSA 1347
    rs1853532181,2
    --78964703(+) TGTAAC/TTTTTC 1 -- us2k10--------
    rs1902022351,2
    --78964780(+) GTGCTC/TTTTTT 1 -- us2k10--------
    rs559096591,2
    C--79055998(+) ATCTA-/TCT   
      A
    /TCTC
    ATCTG
    5 -- int10--------
    rs607613011,2
    C--79182969(+) AAAAA-/A/AA  
            
    CACTC
    5 -- int12NA 4
    rs1495774071,2
    --79210820(+) CATCCA/GTGGAT 2 -- us2k10--------
    rs1924788281,2
    --79210995(+) TCACCA/TCACAG 2 -- us2k10--------
    rs123197241,2
    --81651704(+) CTTTAA/GAAGAA 10 -- ds50010--------
    rs731560451,2
    C,F--81651709(+) AAAGAA/GAGAAA 10 -- ds50011Minor allele frequency- G:0.02NA 120

    HapMap Linkage Disequilibrium report for PPFIA2 (81652045 - 81902045 bp, first 250kb of PPFIA2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PPFIA2 (see all 29):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677852CNV Deletion23128226
    esv2746121CNV Deletion23290073
    esv2669190CNV Deletion23128226
    esv2674428CNV Deletion23128226
    esv2667992CNV Deletion23128226
    esv2660013CNV Deletion23128226
    esv2776CNV Deletion18987735
    esv2673338CNV Deletion23128226
    esv2746120CNV Deletion23290073
    nsv53023CNV Insertion16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPFIA2
    DNA2.0 Custom Variant and Variant Library Synthesis for PPFIA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603143    OMIM disorders: --

    10 diseases for PPFIA2:    
    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    myopia
    cerebritis    pulmonary function    atherosclerosis    schizophrenia
    prostate cancer    prostatitis


    PPFIA2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PPFIA2
    Human Genome Epidemiology (HuGE) Navigator: PPFIA2 (1 document)

    Export disorders for PPFIA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PPFIA2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with PPFIA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase- interacting proteins. (PubMed id 9624153)1, 2, 3 Serra-Pages C.... Streuli M. (J. Biol. Chem. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Association mapping of the high-grade myopia MYP3 locus reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2. (PubMed id 23422819)1 Hawthorne F....Young T.L. (amp 2013)
    4. Genome-wide association study of multiplex schizophrenia pedigrees. (PubMed id 22885689)1 Levinson D.F....Holmans P.A. (Am J Psychiatry 2012)
    5. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (PLoS ONE 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Liprin-mediated large signaling complex organization revealed by the liprin-I+/CASK and liprin-I+/liprin-I^ complex structures. (PubMed id 21855798)1 Wei Z....Zhang M. (Mol. Cell 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    10. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PubMed id 18782753)1 Goudreault M.... Gingras A.C. (Mol. Cell. Proteomics 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8499 HGNC: 9246 AceView: PPFIA2 Ensembl:ENSG00000139220 euGenes: HUgn8499
    ECgene: PPFIA2 H-InvDB: PPFIA2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PPFIA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPFIA2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PPFIA2 gene:
    Search GeneIP for patents involving PPFIA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PPFIA2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PPFIA2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PPFIA2  
     OriGene qSTAR qPCR primer pairs in human, mouse for PPFIA2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PPFIA2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PPFIA2   OriGene Custom Protein Services for PPFIA2  

     
     
     Block miRNA regulation of human, mouse, rat PPFIA2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PPFIA2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPFIA2 Predesigned siRNA for gene silencing in human, mouse, rat PPFIA2
     QuantiFast Probe-based Assays in human, mouse, rat PPFIA2 QuantiTect SYBR Green Assays in human, mouse, rat PPFIA2
     Custom PCR Arrays for PPFIA2 Search Chromatin IP Primers for PPFIA2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPFIA2  Search GeneGlobe Interaction Network for PPFIA2
     Regulatory tfbs in PPFIA2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PPFIA2 GenScript cDNA clones with any tag delivered in your preferred vector for PPFIA2
     GenScript Custom Assay Services for PPFIA2 GenScript Custom overexpressing Cell Line Services for PPFIA2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PPFIA2 (LIPA2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PPFIA2 antibodies
     PPFIA2 lysates
     Antibodies for PPFIA2
     See all of Abcam's Antibodies, Kits and Proteins for PPFIA2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PPFIA2
     Antibodies for PPFIA2
     ELISAs for PPFIA2
     CLIAs for PPFIA2



     Browse ESI BIO Cell Lines and PureStem Progenitors for PPFIA2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPFIA2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PPFIA2
     SwitchGear Promoter luciferase reporter plasmids for PPFIA2
     ThermoFisher Antibodies for PPFIA2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPFIA2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPFIA2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPFIA2
     LSBio Antibodies in human, mouse, rat for PPFIA2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PPFIA2 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4