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Aliases for PPFIA2 Gene

Aliases for PPFIA2 Gene

  • Protein Tyrosine Phosphatase, Receptor Type, F Polypeptide (PTPRF), Interacting Protein (Liprin), Alpha 2 2 3
  • Protein Tyrosine Phosphatase Receptor Type F Polypeptide-Interacting Protein Alpha-2 4
  • PTPRF-Interacting Protein Alpha-2 4
  • Liprin-Alpha-2 3
  • Liprin-Alpha2 2

External Ids for PPFIA2 Gene

Previous GeneCards Identifiers for PPFIA2 Gene

  • GC12M084491
  • GC12M082017
  • GC12M081584
  • GC12M080155
  • GC12M078710

Summaries for PPFIA2 Gene

Entrez Gene Summary for PPFIA2 Gene

  • The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions in mammals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for PPFIA2 Gene

PPFIA2 (Protein Tyrosine Phosphatase, Receptor Type, F Polypeptide (PTPRF), Interacting Protein (Liprin), Alpha 2) is a Protein Coding gene. An important paralog of this gene is KAZN.

UniProtKB/Swiss-Prot for PPFIA2 Gene

  • Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPFIA2 Gene

Genomics for PPFIA2 Gene

Genomic Location for PPFIA2 Gene

Start:
81,257,975 bp from pter
End:
81,759,553 bp from pter
Size:
501,579 bases
Orientation:
Minus strand

Genomic View for PPFIA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPFIA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPFIA2 Gene

Proteins for PPFIA2 Gene

  • Protein details for PPFIA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75334-LIPA2_HUMAN
    Recommended name:
    Liprin-alpha-2
    Protein Accession:
    O75334
    Secondary Accessions:
    • B3KVT5
    • B3KXA0
    • B7Z2A6
    • B7Z3U9
    • B7Z663
    • B7ZKZ5
    • E7ERB8
    • E7ETG6
    • F8VP68
    • Q2M3G8

    Protein attributes for PPFIA2 Gene

    Size:
    1257 amino acids
    Molecular mass:
    143291 Da
    Quaternary structure:
    • Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS.

    Three dimensional structures from OCA and Proteopedia for PPFIA2 Gene

    Alternative splice isoforms for PPFIA2 Gene

neXtProt entry for PPFIA2 Gene

Proteomics data for PPFIA2 Gene at MOPED

Post-translational modifications for PPFIA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPFIA2 Gene

Domains for PPFIA2 Gene

Gene Families for PPFIA2 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing

Protein Domains for PPFIA2 Gene

Graphical View of Domain Structure for InterPro Entry

O75334

UniProtKB/Swiss-Prot:

LIPA2_HUMAN :
  • O75334
Domain:
  • The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS
  • Contains 3 SAM (sterile alpha motif) domains.
Family:
  • Belongs to the liprin family. Liprin-alpha subfamily.
genes like me logo Genes that share domains with PPFIA2: view

Function for PPFIA2 Gene

Molecular function for PPFIA2 Gene

UniProtKB/Swiss-Prot Function: Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.

Gene Ontology (GO) - Molecular Function for PPFIA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0005515 protein binding IPI 12923177
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with PPFIA2: view

Phenotypes for PPFIA2 Gene

genes like me logo Genes that share phenotypes with PPFIA2: view

Animal Model Products

CRISPR Products

miRNA for PPFIA2 Gene

miRTarBase miRNAs that target PPFIA2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPFIA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PPFIA2 Gene

Localization for PPFIA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPFIA2 Gene

Cytoplasm. Cell surface. Note=Colocalizes with PTPRF at the cell surface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPFIA2 Gene COMPARTMENTS Subcellular localization image for PPFIA2 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for PPFIA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9624153
GO:0005829 cytosol TAS --
GO:0009986 cell surface IEA --
GO:0045202 synapse --
GO:0048786 presynaptic active zone TAS 15217342
genes like me logo Genes that share ontologies with PPFIA2: view

Pathways for PPFIA2 Gene

SuperPathways for PPFIA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPFIA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion TAS 9624153
GO:0007165 signal transduction --
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0014047 glutamate secretion TAS --
genes like me logo Genes that share ontologies with PPFIA2: view

No data available for Pathways by source for PPFIA2 Gene

Transcripts for PPFIA2 Gene

Unigene Clusters for PPFIA2 Gene

Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPFIA2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PPFIA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPFIA2 Gene

No ASD Table

Relevant External Links for PPFIA2 Gene

GeneLoc Exon Structure for
PPFIA2
ECgene alternative splicing isoforms for
PPFIA2

Expression for PPFIA2 Gene

mRNA expression in normal human tissues for PPFIA2 Gene

mRNA differential expression in normal tissues according to GTEx for PPFIA2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.9), Brain - Anterior cingulate cortex (BA24) (5.5), Brain - Cortex (4.4), and Brain - Hippocampus (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPFIA2 Gene

SOURCE GeneReport for Unigene cluster for PPFIA2 Gene Hs.506216

mRNA Expression by UniProt/SwissProt for PPFIA2 Gene

O75334-LIPA2_HUMAN
Tissue specificity: Expressed only in brain.
genes like me logo Genes that share expressions with PPFIA2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PPFIA2 Gene

Orthologs for PPFIA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPFIA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPFIA2 35
  • 99.79 (n)
  • 100 (a)
PPFIA2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPFIA2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPFIA2 35
  • 94.03 (n)
  • 99.28 (a)
PPFIA2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppfia2 35
  • 90.51 (n)
  • 98.81 (a)
Ppfia2 16
Ppfia2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPFIA2 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPFIA2 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppfia2 35
  • 90.25 (n)
  • 98.96 (a)
chicken
(Gallus gallus)
Aves PPFIA2 35
  • 83.77 (n)
  • 95.1 (a)
PPFIA2 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPFIA2 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppfia2 35
  • 80.37 (n)
  • 93.13 (a)
zebrafish
(Danio rerio)
Actinopterygii ppfia2 35
  • 72.89 (n)
  • 87.03 (a)
ppfia2 36
  • 86 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001469 35
  • 56.2 (n)
  • 59.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta Liprin-alpha 35
  • 53.99 (n)
  • 58.1 (a)
Liprin-alpha 36
  • 52 (a)
OneToMany
CG11206 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea syd-2 35
  • 53.89 (n)
  • 52.39 (a)
syd-2 36
  • 47 (a)
OneToMany
syd-2 37
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNM67 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7184 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
Species with no ortholog for PPFIA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPFIA2 Gene

ENSEMBL:
Gene Tree for PPFIA2 (if available)
TreeFam:
Gene Tree for PPFIA2 (if available)

Paralogs for PPFIA2 Gene

Paralogs for PPFIA2 Gene

Pseudogenes.org Pseudogenes for PPFIA2 Gene

genes like me logo Genes that share paralogs with PPFIA2: view

Variants for PPFIA2 Gene

Sequence variations from dbSNP and Humsavar for PPFIA2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs726 -- 81,344,805(-) AAAAT(C/G)AAGAA intron-variant
rs871801 -- 81,400,474(+) TTTAC(A/C)GATCT intron-variant
rs871802 -- 81,400,955(-) TATGC(A/C)GTGAA intron-variant
rs879071 -- 81,469,590(-) AGGCT(A/C)TTTTG intron-variant
rs949750 -- 81,503,217(-) AATTT(A/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPFIA2 Gene

Variant ID Type Subtype PubMed ID
nsv899343 CNV Loss 21882294
nsv521788 CNV Loss 19592680
nsv470308 CNV Gain 18288195
nsv820229 CNV Gain 19587683
nsv53023 CNV Insertion 16902084
esv1228005 CNV Insertion 17803354
esv2496739 CNV Loss 19546169
esv2677852 CNV Deletion 23128226
esv2673338 CNV Deletion 23128226
nsv826452 CNV Loss 20364138
esv1408686 CNV Insertion 17803354
dgv1466n71 CNV Loss 21882294
esv2660013 CNV Deletion 23128226
esv2667992 CNV Deletion 23128226
dgv298n67 CNV Loss 20364138
esv2746120 CNV Deletion 23290073
esv2674428 CNV Deletion 23128226
nsv498797 CNV Loss 21111241
nsv790 CNV Loss 18451855
nsv511491 CNV Loss 21212237
nsv512285 CNV Loss 21212237
dgv299n67 CNV Loss 20364138
esv2776 CNV Deletion 18987735
esv24976 CNV Loss 19812545
esv2746121 CNV Deletion 23290073
esv2669190 CNV Deletion 23128226
esv9497 CNV Loss 19470904
nsv498798 CNV Loss 21111241
nsv514675 CNV Loss 21397061

Relevant External Links for PPFIA2 Gene

HapMap Linkage Disequilibrium report
PPFIA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPFIA2 Gene

Disorders for PPFIA2 Gene

Relevant External Links for PPFIA2

Genetic Association Database (GAD)
PPFIA2
Human Genome Epidemiology (HuGE) Navigator
PPFIA2
genes like me logo Genes that share disorders with PPFIA2: view

No data available for UniProtKB/Swiss-Prot for PPFIA2 Gene

Publications for PPFIA2 Gene

  1. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase- interacting proteins. (PMID: 9624153) Serra-Pages C. … Streuli M. (J. Biol. Chem. 1998) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Liprin-mediated large signaling complex organization revealed by the liprin-I+/CASK and liprin-I+/liprin-I^ complex structures. (PMID: 21855798) Wei Z. … Zhang M. (Mol. Cell 2011) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for PPFIA2 Gene

  • antibodies-online peptides for PPFIA2
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  • antibodies-online kits for PPFIA2

Sources for PPFIA2 Gene

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