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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPFIA2 Gene

protein-coding   GIFtS: 54
GCID: GC12M081584

Protein Tyrosine Phosphatase, Receptor Type, F Polypeptide...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Protein Tyrosine Phosphatase, Receptor Type, F Polypeptide (PTPRF),
Interacting Protein (Liprin), Alpha 21 2
Liprin-alpha21
liprin-alpha-22
Protein Tyrosine Phosphatase Receptor Type F Polypeptide-Interacting
Protein Alpha-23
PTPRF-Interacting Protein Alpha-23

External Ids:    HGNC: 92461   Entrez Gene: 84992   Ensembl: ENSG000001392207   OMIM: 6031435   UniProtKB: O753343   
ORGUL members:         
NONCODE14:n410811      

Export aliases for PPFIA2 gene to outside databases

Previous GC identifers: GC12M084491 GC12M082017 GC12M080155 GC12M078710


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPFIA2 Gene:
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin)
family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are
known to be important for axon guidance and mammary gland development. It has been proposed that liprins are
multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR
family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine
protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions
in mammals. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Sep 2013)

GeneCards Summary for PPFIA2 Gene: 
PPFIA2 (protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with PPFIA2 include cerebral cavernous malformations 3, and cavernous malformation. GO annotations related to this gene include protein binding. An important paralog of this gene is KAZN.

UniProtKB/Swiss-Prot: LIPA2_HUMAN, O75334
Function: Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal
adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane,
possibly regulating their interaction with the extracellular environment and their association with substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPFIA2 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   Nkx2-5   LCR-F1   CREB   deltaCREB   AP-2alpha isoform 4   ZIC2/Zic2   AP-2alpha   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPFIA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PPFIA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPFIA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.31   Ensembl cytogenetic band:  12q21.31   HGNC cytogenetic band: 12q21.31

PPFIA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPFIA2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M081584:  view genomic region     (about GC identifiers)

Start:
81,652,045 bp from pter      End:
82,153,332 bp from pter
Size:
501,288 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LIPA2_HUMAN, O75334 (See protein sequence)
Recommended Name: Liprin-alpha-2  
Size: 1257 amino acids; 143291 Da
Subunit: Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase
domain of PTPRD, PTPRF and PTPRS
Subcellular location: Cytoplasm. Cell surface. Note=Colocalizes with PTPRF at the cell surface
2 PDB 3D structures from and Proteopedia for PPFIA2:
3TAC (3D)        3TAD (3D)    
Secondary accessions: B3KVT5 B3KXA0 B7Z2A6 B7Z3U9 B7Z663 B7ZKZ5 E7ERB8 E7ETG6 F8VP68 Q2M3G8
Alternative splicing: 8 isoforms:  O75334-1   O75334-2   O75334-3   O75334-4   O75334-5   O75334-6   O75334-7   O75334-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPFIA2: NX_O75334

Explore proteomics data for PPFIA2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75334

  • PPFIA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPFIA2 Protein Expression
    REFSEQ proteins (10 alternative transcripts): 
    NP_001207402.1  NP_001207403.1  NP_001207404.1  NP_001207405.1  NP_001207406.1  NP_001207407.1  NP_001207408.1  NP_001207409.1  
    NP_001269465.1  NP_003616.2  

    ENSEMBL proteins: 
     ENSP00000450337   ENSP00000449558   ENSP00000450298   ENSP00000438337   ENSP00000449821  
     ENSP00000447273   ENSP00000385093   ENSP00000449338   ENSP00000388373   ENSP00000447868  
     ENSP00000447189   ENSP00000449524   ENSP00000448941   ENSP00000447792   ENSP00000446555  
     ENSP00000449469   ENSP00000447918   ENSP00000327416   ENSP00000445532  

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    Cloud-Clone Corp. Proteins for PPFIA2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0009986cell surface IEA--
    GO:0045202synapse IEA--

    PPFIA2 for ontologies           About GeneDecksing



    PPFIA2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SAMD: Sterile alpha motif (SAM) domain containing

    4 InterPro protein domains:
     IPR021129 SAM_type1
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR011510 SAM_2

    Graphical View of Domain Structure for InterPro Entry O75334

    ProtoNet protein and cluster: O75334

    2 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: LIPA2_HUMAN, O75334
    Domain: The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type
    alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction
    with PTPRD, PTPRF and PTPRS
    Similarity: Belongs to the liprin family. Liprin-alpha subfamily
    Similarity: Contains 3 SAM (sterile alpha motif) domains


    PPFIA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIPA2_HUMAN, O75334
    Function: Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal
    adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane,
    possibly regulating their interaction with the extracellular environment and their association with substrates

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005515protein binding IPI12923177
         
    PPFIA2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PPFIA2:
     Decreased cilium length after   Decreased viability  Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPFIA2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPFIA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/17 Interacting proteins for PPFIA2 (O753343 ENSP000003883734) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERC2O150833, ENSP000002882214I2D: score=3 STRING: ENSP00000288221
    GIT1Q9Y2X73, ENSP000003783384I2D: score=3 STRING: ENSP00000378338
    PPP2R1AP301533, ENSP000003248044I2D: score=2 STRING: ENSP00000324804
    PTPRSQ133323, ENSP000003499324I2D: score=2 STRING: ENSP00000349932
    CASKO149363, ENSP000003674084I2D: score=1 STRING: ENSP00000367408
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007160cell-matrix adhesion TAS9624153

    PPFIA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPFIA2 (LIPA2)

    Search CenterWatch for drugs/clinical trials and news about PPFIA2 / LIPA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPFIA2 gene (10 alternative transcripts): 
    NM_001220473.2  NM_001220474.2  NM_001220475.2  NM_001220476.2  NM_001220477.2  NM_001220478.2  NM_001220479.2  NM_001220480.2  
    NM_001282536.1  NM_003625.4  

    Unigene Cluster for PPFIA2:

    Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
    Hs.506216  [show with all ESTs]
    Unigene Representative Sequence: NM_001220473
    18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000549396(uc021rbf.1 uc010sug.2 uc021rbg.1 uc021rbh.1 uc021rbi.1 uc021rbj.1 uc001szo.2)
    ENST00000550584(uc021rbe.1 uc021rbk.1 uc021rbl.1) ENST00000549325
    ENST00000545296(uc010sue.2) ENST00000541570 ENST00000551461 ENST00000550359
    ENST00000407050 ENST00000548586 ENST00000443686 ENST00000552948 ENST00000550018
    ENST00000551147 ENST00000547180 ENST00000549344 ENST00000549917 ENST00000553058
    ENST00000548670
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate PPFIA2 (see all 48):
    hsa-miR-21* hsa-miR-3607-3p hsa-miR-15a hsa-miR-128 hsa-miR-30d hsa-miR-301a hsa-miR-507 hsa-miR-424
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    Additional mRNA sequence: 

    AB210009.1 AF034799.1 AK123372.1 AK126971.1 AK294505.1 AK296380.1 AK297372.1 AK299853.1 
    AK302658.1 AK307524.1 AL157453.1 BC104912.1 BC143485.1 NR_038265.1 

    11 DOTS entries:

    DT.97792131  DT.409054  DT.100008354  DT.101981713  DT.107168  DT.121182285  DT.121182319  DT.121182277 
    DT.97800233  DT.97807395  DT.40210520 

    24/33 AceView cDNA sequences (see all 33):

    BM689808 AK123372 AL157453 AK126971 BQ027545 BM661844 NM_003625 AF034799 
    BX507846 BX951956 BM545514 BQ008801 BF002886 BU153957 AL712783 N45544 
    AW014561 BU568524 CB051855 AL713132 BQ340238 BM718222 N51002 BF525425 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPFIA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PPFIA2 Expression
    About this image


    See PPFIA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPFIA2

    SOURCE GeneReport for Unigene cluster: Hs.506216

    UniProtKB/Swiss-Prot: LIPA2_HUMAN, O75334
    Tissue specificity: Expressed only in brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PPFIA2 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppfia21 , 5 protein tyrosine phosphatase, receptor type, f polypeptide more1, 5 90.51(n)1
    98.81(a)1
      10 (55.39 cM)5
    3278141  NM_001205341.11  NP_001192270.11 
     1064703105 
    chicken
    (Gallus gallus)
    Aves PPFIA21 protein tyrosine phosphatase, receptor type, f polypeptide more 84.39(n)
    95.92(a)
      417877  XM_416120.3  XP_416120.3 
    lizard
    (Anolis carolinensis)
    Reptilia PPFIA26
    protein tyrosine phosphatase, receptor type, f pol...
    89(a)
    1 ↔ 1
    5(36500401-36843480)
    zebrafish
    (Danio rerio)
    Actinopterygii ppfia21 protein tyrosine phosphatase, receptor type, f polypeptide more 72.87(n)
    87.03(a)
      566597  NM_001045111.1  NP_001038576.1 


    ENSEMBL Gene Tree for PPFIA2 (if available)
    TreeFam Gene Tree for PPFIA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPFIA2 gene
    KAZN2  PPFIBP12  PPFIA42  PPFIA32  PPFIA12  PPFIBP22  
    6 SIMAP similar genes for PPFIA2 using alignment to 12 protein entries:     LIPA2_HUMAN (see all proteins):
    PPFIA2 variant protein    PPFIA1    PPFIA4    PPFIA3    PPFIBP1    KAZN

    PPFIA2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PPFIA2
    PGOHUM00000261317


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8743 SNPs in PPFIA2 are shown (see all 8743)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs719268051,2
    C--78831498(+) AGTGC-/TGTGT 
     GTGTGTG
    TGTGT
    8 -- int10--------
    rs128194421,2
    C,F,H--78964687(+) AAATAA/GTGACA 1 -- us2k118Minor allele frequency- G:0.35NA NS EA WA CSA 1347
    rs1853532181,2
    --78964703(+) TGTAAC/TTTTTC 1 -- us2k10--------
    rs1902022351,2
    --78964780(+) GTGCTC/TTTTTT 1 -- us2k10--------
    rs559096591,2
    C--79055998(+) ATCTA-/TCT   
      A
    /TCTC
    ATCTG
    5 -- int10--------
    rs607613011,2
    C--79182969(+) AAAAA-/A/AA  
            
    CACTC
    5 -- int12NA 4
    rs1495774071,2
    --79210820(+) CATCCA/GTGGAT 2 -- us2k10--------
    rs1924788281,2
    --79210995(+) TCACCA/TCACAG 2 -- us2k10--------
    rs123197241,2
    --81651704(+) CTTTAA/GAAGAA 10 -- ds50010--------
    rs731560451,2
    C,F--81651709(+) AAAGAA/GAGAAA 10 -- ds50011Minor allele frequency- G:0.02NA 120

    HapMap Linkage Disequilibrium report for PPFIA2 (81652045 - 81902045 bp, first 250kb of PPFIA2)

    Structural Variations
         Database of Genomic Variants (DGV) 10/29 variations for PPFIA2 (see all 29):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677852CNV Deletion23128226
    esv2746121CNV Deletion23290073
    esv2669190CNV Deletion23128226
    esv2674428CNV Deletion23128226
    esv2667992CNV Deletion23128226
    esv2660013CNV Deletion23128226
    esv2776CNV Deletion18987735
    esv2673338CNV Deletion23128226
    esv2746120CNV Deletion23290073
    nsv53023CNV Insertion16902084

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603143    OMIM disorders: --

    7 diseases for PPFIA2:    About MalaCards
    cerebral cavernous malformations 3    cavernous malformation    cerebral cavernous malformation    prostate cancer
    prostatitis    cerebritis    schizophrenia


    PPFIA2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PPFIA2
    Human Genome Epidemiology (HuGE) Navigator: PPFIA2 (1 document)

    Export disorders for PPFIA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPFIA2 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with PPFIA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase- interacting proteins. (PubMed id 9624153)1, 2, 3 Serra-Pages C.... Streuli M. (1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Association mapping of the high-grade myopia MYP3 locu s reveals novel candidates UHRF1BP1L, PTPRR, and PPFIA2. (PubMed id 23422819)1 Hawthorne F....Young T.L. (2013)
    4. Genome-wide association study of multiplex schizophren ia pedigrees. (PubMed id 22885689)1 Levinson D.F....Holmans P.A. (2012)
    5. Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Liprin-mediated large signaling complex organization revealed by the liprin-I+/CASK and liprin-I+/liprin-I^ complex structures. (PubMed id 21855798)1 Wei Z....Zhang M. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein. (PubMed id 18782753)1 Goudreault M....Gingras A.C. (2009)
    10. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8499 HGNC: 9246 AceView: PPFIA2 Ensembl:ENSG00000139220 euGenes: HUgn8499
    ECgene: PPFIA2 H-InvDB: PPFIA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPFIA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPFIA2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPFIA2 gene:
    Search GeneIP for patents involving PPFIA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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