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GIFtS

PPEF1 Gene

protein-coding   GIFtS: 56
GCID: GC0XP018694

protein phosphatase, EF-hand calcium binding domain 1


(Previous symbol: PPEF)
 Explore 6 diseases affiliated with
PPEF1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PPEF1    

Aliases
for PPEF1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Phosphatase, EF-Hand Calcium Binding Domain 11 2     EC 3.1.3.163 8
PPEF1 2 3     Protein Phosphatase 7, Catalytic Subunit, Alpha Isozyme2
PPP7CA1 2     Protein Phosphatase, Serine/Threonine Type, With EF-Hands2
Protein Phosphatase With EF Calcium-Binding Domain2 3     Serine/Threonine Protein Phosphatase 72
Serine/Threonine-Protein Phosphatase 72 3     Serine/Threonine-Protein Phosphatase With EF-Hands 12
PP72 3     PPEF-13
PPP7C2 3     

External Ids:    HGNC: 92431   Entrez Gene: 54752   Ensembl: ENSG000000867177   OMIM: 3001095   UniProtKB: O148293   

Export aliases for PPEF1 gene to outside databases

Previous GC identifers: GC0XP018253 GC0XP017375 GC0XP017911 GC0XP018070 GC0XP018468 GC0XP018618 GC0XP016462


Summaries
for PPEF1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PPEF1:
This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains
a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although
its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function
and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene.
Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PPE1_HUMAN, O14829
Function: May have a role in the recovery or adaptation response of photoreceptors. May have a role in development

Gene Wiki entry for PPEF1


Genomic Views
for PPEF1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPEF1 gene promoter:
         GCNF   CREB   RORalpha1   PPAR-gamma1   deltaCREB   GCNF-1   PPAR-gamma2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPEF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PPEF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPEF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22   Ensembl cytogenetic band:  Xp22.13   HGNC cytogenetic band: Xp22

PPEF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPEF1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP018694:  view genomic region     (about GC identifiers)

Start:
 18,694,029 bp from pter      End:
 18,846,039 bp from pter
Size:
 152,011 bases      Orientation:
 plus strand

Proteins
for PPEF1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PPE1_HUMAN, O14829 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase with EF-hands 1  
Size: 653 amino acids; 75792 Da
Cofactor: Binds 1 iron ion per subunit (By similarity)
Cofactor: Binds 1 manganese ion per subunit (By similarity)
Cofactor: Magnesium (By similarity)
Secondary accessions: A6NHP4 A8K348 O15253 Q9NU21 Q9UJH0
Alternative splicing: 5 isoforms:  O14829-1   O14829-2   O14829-3   O14829-4   O14829-5   (May have no functional significance)

Explore the universe of human proteins at neXtProt for PPEF1: NX_O14829

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14829

    • 4/5 DME Specific Peptides for PPEF1 (O14829) (see all 5)
     GDFVDRG  NLRYGFTKE  IFYKNGLPS  CGDLHGKLDDL 

    PPEF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_006231.2  NP_689410.1  NP_689412.1  

    ENSEMBL proteins: 
     ENSP00000354871   ENSP00000419948   ENSP00000418623   ENSP00000419273   ENSP00000352806  
     ENSP00000341892   ENSP00000437785   ENSP00000441289  

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    Uscn Proteins for PPEF1


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    Uscn ELISAs and CLIAs for PPEF1

    Protein Domains /
    Families
    for PPEF1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PPEF1 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR018248 EF-hand
     IPR013235 PPP_dom
     IPR012008 Ser/Thr-Pase_EF-hand_contain

    Graphical View of Domain Structure for InterPro Entry O14829

    ProtoNet protein and cluster: O14829

    2 Blocks protein families:
    IPB000048 IQ calmodulin-binding region
    IPB006186 Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase


    UniProtKB/Swiss-Prot: PPE1_HUMAN, O14829
    Similarity: Belongs to the PPP phosphatase family
    Similarity: Contains 3 EF-hand domains
    Similarity: Contains 1 IQ domain


    Function
    for PPEF1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PPE1_HUMAN, O14829
    Function: May have a role in the recovery or adaptation response of photoreceptors. May have a role in development
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate
    Enzyme regulation: Activated by calcium
    Biophysicochemical properties: pH dependence: Optimum pH is 8.0;

         Genatlas biochemistry entry for PPEF1:
    serine-threonine phosphatase with two alternatively spliced forms,expressed in sensory neurons of neural crest
    origin,homologous to Drosophila retinal degeneration C (rdgc)

    Enzyme Number (IUBMB): EC 3.1.3.161 2

    miRNA
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    hsa-miR-3688-3p
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004722protein serine/threonine phosphatase activity TAS9215685
    GO:0005506iron ion binding IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI12051765


    PPEF1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PPEF1:
     Decreased viability 

    Animal Models:
         Mouse knock-out Ppef1tm1Nat for PPEF1
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ppef1):
     normal  vision/eye 

    PPEF1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PPEF1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPEF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for PPEF1 (O148291, 3 ENSP000003548714) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=4 STRING: ENSP00000349467
    CALM2P621583, ENSP000002722984I2D: score=4 STRING: ENSP00000272298
    CALM3P621583, ENSP000002912954I2D: score=4 STRING: ENSP00000291295
    TP53ENSP000002693054STRING: ENSP00000269305
    HDAC3ENSP000003029674STRING: ENSP00000302967
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS9215685
    GO:0050906detection of stimulus involved in sensory perception IEA--


    PPEF1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PPEF1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPEF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PPEF1

    6 HMDB Compounds for PPEF1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    IronArmco iron (see all 19)7439-89-6--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    2 Novoseek chemical compound relationships for PPEF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 54.8 1 10736728 (1)
    serine 42.5 1 10736728 (1)

    Search CenterWatch for drugs/clinical trials and news about PPEF1 / PPE1 

    Transcripts
    for PPEF1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PPEF1 gene (5 alternative transcripts): 
    NM_006240.2  NM_152224.1  NM_152226.1  NM_152223.1  NM_152225.1  

    Unigene Cluster for PPEF1:

    Protein phosphatase, EF-hand calcium binding domain 1
    Hs.211589  [show with all ESTs]
    Unigene Representative Sequence: BC036026
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486029 ENST00000361511(uc004cyp.3 uc004cyq.3 uc004cyr.3 uc004cys.3 uc011mja.2 uc011mjb.2)
    ENST00000471570 ENST00000496616 ENST00000472826 ENST00000496075 ENST00000379962
    ENST00000470157 ENST00000359763 ENST00000349874 ENST00000543630 ENST00000544635


    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate PPEF1:
    hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmid: PPEF1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF023455.1 AK290463.1 AK292235.1 AK295504.1 AK300815.1 AK315809.1 BC036026.1 X97867.1 

    5 DOTS entries:

    DT.456404  DT.100751834  DT.100021128  DT.95266645  DT.91864423 

    24/38 AceView cDNA sequences (see all 38):

    AA450013 NM_006240 AA621346 NM_152225 AF023455 BC036026 NM_152223 AA452634 
    NM_152226 NM_152224 D44816 X97867 BF432013 BF059728 BI463706 BI913019 
    BX477659 BE546038 BI560122 BX460450 H08394 T16779 AF027977 AL561699 

    GeneLoc Exon Structure


    Expression
    for PPEF1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPEF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PPEF1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSpermatidGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PPEF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPEF1

    SOURCE GeneReport for Unigene cluster: Hs.211589

    UniProtKB/Swiss-Prot: PPE1_HUMAN, O14829
    Tissue specificity: Detected in retina and retinal derived Y-79 retinoblastoma cells. Also found in fetal brain

        SABiosciences Expression via Pathway-Focused PCR Array including PPEF1: 
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    In Situ
    Assay Products:     
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    Orthologs
    for PPEF1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPEF1 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PPEF11 protein phosphatase, EF-hand calcium binding domain more 62.74(n)
    55(a)    		   427999  XM_003640490.1  XP_003640538.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PPEF16
    		 --
    		 56(a)
    		 1 ↔ 1
    		 3(123095997-123138043)
    zebrafish
    (Danio rerio)    		 Actinopterygii ppef16
    		 protein phosphatase, EF-hand calcium binding domai...
    		 48(a)
    		 1 ↔ 1
    		 11(31129422-31156412)
    fruit fly
    (Drosophila melanogaster)    		 Insecta rdgC3 deactivation of rhodopsin mediated signaling
    calmodulin more    		 39(a)   77B1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea pef-16
    		 Phosphatase with EF hands family member (pef-1)
    		 37(a)
    		 1 → many
    		 III(919517-926303)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G481206
    PP76
    (see all 3)    		 serine/threonine-protein phosphatase 7
    (see all 3)    		 7(a)
    24(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 1(17773688-17779955)
    5(25561160-25563274)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 Ser/Thr protein phosphatase family protein, putati...
    		 22(a)
    		 possible ortholog
    		 8(25434383-25438139)


    ENSEMBL Gene Tree for PPEF1 (if available)
    TreeFam Gene Tree for PPEF1 (if available) 

    Paralogs
    for PPEF1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPEF1 gene
    PPEF22  PPP5C2  
    10 SIMAP similar genes for PPEF1 using alignment to 6 protein entries:     PPE1_HUMAN (see all proteins):
    PPP1CB    PPEF2    PPP3CB    PPP3CA    PPP5C    PPP4C
    PPP6C    PPP1CA    PPP2CB    PPP1CC

    PPEF1 for paralogs           About GeneDecksing



    Genomic Variants
    for PPEF1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1757 NCBI SNPs in PPEF1 are shown (see all 1757)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1843740261,2
    		--18707079(+) AAGTTC/TTTATT 3 -- us2k10--------
    rs1893102071,2
    		--18707101(+) TGAAGC/GCTTCA 3 -- us2k10--------
    rs1822038431,2
    		--18707180(+) ATACCA/GGAGAG 3 -- us2k10--------
    rs1121950721,2
    		C,--18707429(+) AAACGT/CCATCT 3 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1875792451,2
    		--18707856(+) TTTTAC/TGCAAA 3 -- us2k10--------
    rs172472431,2
    		C,F,H,--18707857(+) TTTACA/GCAAAT 3 -- us2k117Minor allele frequency- G:0.47NA NS EA 2080
    rs101267071,2
    		C,F,H,--18708077(+) ATTCAA/GCCTTC 3 -- us2k110Minor allele frequency- G:0.13NS NA CSA 1373
    rs101267121,2
    		C,--18708089(+) ACTGTG/CAGGTC 3 -- us2k1 tfbs31Minor allele frequency- C:0.00CSA 1
    rs1894368371,2
    		--18708397(+) AAAGGA/CTTCTC 3 -- us2k10--------
    rs66536391,2
    		C,H,--18708411(+) GAACTC/TTTAGG 3 -- us2k18Minor allele frequency- T:0.00WA NA CSA 12

    HapMap Linkage Disequilibrium report for PPEF1 (18694029 - 18846039 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PPEF1
         2 CNVs: 7775 8301
    Locus Specific Mutation Databases (LSDB): PPEF1

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    Disorders / Diseases
    for PPEF1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PPEF1 for disorders           About GeneDecksing

    OMIM gene information: 300109    OMIM disorders: --

    6 diseases for PPEF1:    About MalaCards
    retinal degeneration    x-linked juvenile retinoschisis    retinitis    retinoschisis
    neuronitis    retinoblastoma


    Export disorders for PPEF1 gene to outside databases

    Publications
    for PPEF1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPEF1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with PPEF1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin. (PubMed id 9215685)1, 2, 3, 9 Montini E.... Franco B. (1997)
    2. Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C. (PubMed id 9326663)1, 2, 3 Sherman P.M....Nathans J. (1997)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    6. Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC). (PubMed id 9430683)1, 2 Huang X. and Honkanen R.E. (1998)
    7. Molecular cloning of a novel PPEF-1 gene variant from a T-cell lymphoblastic lymphoma cell line. (PubMed id 22292511)1 Ho P....Chen H.L. (2012)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1 Gevaert K.... Vandekerckhove J. (2003)
    10. Protein Ser/Thr phosphatases PPEF interact with calmodulin. (PubMed id 12051765)1 Kutuzov M.A....Bennett N. (2002)

    External Searches for PPEF1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PPEF1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5475 HGNC: 9243 AceView: PPEF1 Ensembl:ENSG00000086717 euGenes: HUgn5475
    ECgene: PPEF1 H-InvDB: PPEF1

    Other Databases showing PPEF1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PPEF1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPEF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPEF1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PPEF1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PPEF1 gene:
    Search GeneIP for patents involving PPEF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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