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Aliases for PPDPFL Gene

Aliases for PPDPFL Gene

  • Pancreatic Progenitor Cell Differentiation And Proliferation Factor Like 2 3
  • C8orf22 3 4 5
  • Exocrine Differentiation And Proliferation Factor-Like Protein 3 4
  • Chromosome 8 Open Reading Frame 22 2 5
  • Pancreatic Progenitor Cell Differentiation And Proliferation Factor-Like Protein 3

External Ids for PPDPFL Gene

Previous HGNC Symbols for PPDPFL Gene

  • C8orf22

Summaries for PPDPFL Gene

GeneCards Summary for PPDPFL Gene

PPDPFL (Pancreatic Progenitor Cell Differentiation And Proliferation Factor Like) is a Protein Coding gene.

Additional gene information for PPDPFL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPDPFL Gene

Genomics for PPDPFL Gene

Regulatory Elements for PPDPFL Gene

Enhancers for PPDPFL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H049064 0.8 ENCODE 35 +11.5 11537 2 GTF2F1 TBP JUN MAX RAD21 BRCA1 RFX5 NFYB RCOR1 RUNX3 PPDPFL GC08M049134
GH08H049092 0.5 ENCODE 44.5 +38.6 38635 1 SOX6 POU5F1 ID3 PPDPFL GC08M049134
GH08H048918 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -132.2 -132202 8 FOXA2 ATF1 ARNT ARID4B SIN3A GLI4 BRCA1 YY1 ZNF143 ATF7 PPDPFL SNAI2 PIR61418 GC08M048959
GH08H049110 1 ENCODE 10.2 +56.2 56164 0 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 CAVIN1 NCOA1 SNAI2 PPDPFL GC08M049134
GH08H048427 1.5 FANTOM5 Ensembl ENCODE dbSUPER 5.7 -624.1 -624104 6 JUN NRF1 MAX MNT RAD21 NR2F2 FOSL1 POLR2A FOXP2 MYC LOC101929268 PPDPFL RPL29P19 EFCAB1 MCM4 ENSG00000279881 LOC105375821
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPDPFL on UCSC Golden Path with GeneCards custom track

Genomic Location for PPDPFL Gene

Chromosome:
8
Start:
49,054,311 bp from pter
End:
49,076,090 bp from pter
Size:
21,780 bases
Orientation:
Plus strand

Genomic View for PPDPFL Gene

Genes around PPDPFL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPDPFL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPDPFL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPDPFL Gene

Proteins for PPDPFL Gene

  • Protein details for PPDPFL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWR9-PDPFL_HUMAN
    Recommended name:
    Pancreatic progenitor cell differentiation and proliferation factor-like protein
    Protein Accession:
    Q8WWR9
    Secondary Accessions:
    • G3V137
    • Q8WVI1

    Protein attributes for PPDPFL Gene

    Size:
    84 amino acids
    Molecular mass:
    9188 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PPDPFL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPDPFL Gene

Post-translational modifications for PPDPFL Gene

No Post-translational modifications

Other Protein References for PPDPFL Gene

No data available for DME Specific Peptides for PPDPFL Gene

Domains & Families for PPDPFL Gene

Gene Families for PPDPFL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PPDPFL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPDPFL Gene

Graphical View of Domain Structure for InterPro Entry

Q8WWR9

UniProtKB/Swiss-Prot:

PDPFL_HUMAN :
  • Belongs to the PPDPF family.
Family:
  • Belongs to the PPDPF family.
genes like me logo Genes that share domains with PPDPFL: view

Function for PPDPFL Gene

Phenotypes From GWAS Catalog for PPDPFL Gene

Phenotypes for PPDPFL Gene

GenomeRNAi human phenotypes for PPDPFL:
genes like me logo Genes that share phenotypes with PPDPFL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PPDPFL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PPDPFL Gene

Localization for PPDPFL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPDPFL gene
Compartment Confidence
mitochondrion 2
peroxisome 2
extracellular 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PPDPFL Gene

Pathways & Interactions for PPDPFL Gene

SuperPathways for PPDPFL Gene

No Data Available

Interacting Proteins for PPDPFL Gene

Gene Ontology (GO) - Biological Process for PPDPFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001708 cell fate specification IBA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0031017 exocrine pancreas development IBA --
genes like me logo Genes that share ontologies with PPDPFL: view

No data available for Pathways by source and SIGNOR curated interactions for PPDPFL Gene

Drugs & Compounds for PPDPFL Gene

No Compound Related Data Available

Transcripts for PPDPFL Gene

mRNA/cDNA for PPDPFL Gene

(4) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PPDPFL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PPDPFL Gene

No ASD Table

Relevant External Links for PPDPFL Gene

GeneLoc Exon Structure for
PPDPFL
ECgene alternative splicing isoforms for
PPDPFL

Expression for PPDPFL Gene

NURSA nuclear receptor signaling pathways regulating expression of PPDPFL Gene:

PPDPFL

Evidence on tissue expression from TISSUES for PPDPFL Gene

  • Muscle(4.5)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPDPFL Gene

Orthologs for PPDPFL Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPDPFL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf22 33
  • 100 (n)
C8orf22 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C29H8orf22 33
  • 85.23 (n)
oppossum
(Monodelphis domestica)
Mammalia C8orf22 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C8orf22 34
  • 65 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C14H8orf22 34
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves C8orf22 34
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C8orf22 34
  • 52 (a)
OneToOne
Species where no ortholog for PPDPFL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PPDPFL Gene

ENSEMBL:
Gene Tree for PPDPFL (if available)
TreeFam:
Gene Tree for PPDPFL (if available)

Paralogs for PPDPFL Gene

No data available for Paralogs for PPDPFL Gene

Variants for PPDPFL Gene

Sequence variations from dbSNP and Humsavar for PPDPFL Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000054243 -- 49,063,837(+) GGATT(C/G)GGGGG intron-variant
rs1000360788 -- 49,052,898(+) TTAGC(A/C)AGAAT upstream-variant-2KB
rs1000531519 -- 49,064,160(+) ATTCC(C/T)AGGTA intron-variant
rs1000571989 -- 49,068,429(+) ACTTA(C/T)GAAGA intron-variant
rs1000772908 -- 49,052,631(+) TCAAA(A/C)GGGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPDPFL Gene

Variant ID Type Subtype PubMed ID
esv2736979 CNV deletion 23290073
nsv1025068 CNV gain 25217958

Variation tolerance for PPDPFL Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPDPFL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPDPFL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPDPFL Gene

Disorders for PPDPFL Gene

Relevant External Links for PPDPFL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPDPFL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPDPFL

No disorders were found for PPDPFL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPDPFL Gene

Publications for PPDPFL Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington JJ … Ducar M (Nature biotechnology 2001) 3 4 60
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for PPDPFL Gene

Sources for PPDPFL Gene

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