PPCS Gene

Aliases
for PPCS gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Previous GC identifers: GC01P042592 GC01P042694 GC01P041042

Summaries
for PPCS gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Genomic Views
for PPCS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

SwitchGear Promoter luciferase reporter plasmid: PPCS promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPCS

PPCS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P042921:  view genomic region     (about GC identifiers)

Proteins
for PPCS gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

1 PDB 3D structure from and Proteopedia for PPCS:

1P9O (3D)    

Explore the universe of human proteins at neXtProt for PPCS: NX_Q9HAB8

Explore proteomics data for PPCS at MOPED

Post-translational modifications: 

PPCS Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for PPCS
	GenScript Custom Purified and Recombinant Proteins Services for PPCS
	Novus Biologicals PPCS Proteins
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for PPCS
	Cloud-Clone Corp. Proteins for PPCS
	Search eBioscience for Proteins for PPCS
	Search GeneTex for Proteins for PPCS
	antibodies-online proteins for PPCS (4 products)
	antibodies-online peptides for PPCS

PPCS Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for PPCS
	Novus Biologicals PPCS Antibodies
	Abcam antibodies for PPCS
	Cloud-Clone Corp. Antibodies for PPCS
	ThermoFisher Antibodies for PPCS
	antibodies-online antibodies for PPCS (7 products)

PPCS Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for PPCS
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PPCS
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for PPCS Cloud-Clone Corp. CLIAs for PPCS
	Search eBioscience for ELISAs for PPCS
	antibodies-online kits for PPCS (4 products)

Domains /
Families
for PPCS gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

ProtoNet protein and cluster: Q9HAB8

Find genes that share domains with PPCS           About GenesLikeMe

Function
for PPCS gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

     Enzyme Number (IUBMB): EC 6.3.2.5¹

     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for PPCS

miRNA Products:		miRTarBase miRNAs that target PPCS: hsa-mir-186-5p (MIRT044998), hsa-mir-32-5p (MIRT028370), hsa-mir-375 (MIRT019904)
		Block miRNA regulation of human, mouse, rat PPCS using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate PPCS (see all 10):
		hsa-miR-137 hsa-miR-92a hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-211 hsa-miR-204 hsa-miR-4325
		SwitchGear 3'UTR luciferase reporter plasmid: PPCS 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for PPCS
		Predesigned siRNA for gene silencing in human, mouse, rat PPCS

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for PPCS

Clone Products:		OriGene clones in human, mouse for PPCS (see all 13) OriGene ORF clones in mouse, rat for PPCS OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): PPCS (NM_024664)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPCS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPCS

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PPCS
		Browse ESI BIO Cell Lines and PureStem Progenitors for PPCS

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPCS

Localization
for PPCS gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	4
nucleus	2
extracellular	1
mitochondrion	1
peroxisome	1

About this image

Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for PPCS gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for PPCS About     See pathways by source

Powered by

	SuperPath	Selected contained pathways About (see all per SuperPath)
1	Defective BTD causes biotidinase deficiency	Defective BTD causes biotidinase deficiency 1.00 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG 1.00 Defective MMAA causes methylmalonic aciduria type cblA 1.00 Defective GIF causes intrinsic factor deficiency 1.00 Defects in cobalamin (B12) metabolism 1.00 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE 1.00 Defects in biotin (Btn) metabolism 1.00 Defective CUBN causes hereditary megaloblastic anemia 1 1.00
2	Metabolism	Metabolism 0.38 Metabolic pathways 0.38
3	Pantothenate and CoA biosynthesis	Pantothenate and CoA biosynthesis
4	Disease	Disease

1 BioSystems Pathway for PPCS

coenzyme A biosynthesis

1 Reactome Pathway for PPCS

Coenzyme A biosynthesis

2 Kegg Pathways  (Kegg details for PPCS)

	Pantothenate and CoA biosynthesis
	Metabolic pathways

    Custom Pathway & Disease-focused RT² Profiler PCR Arrays for PPCS
Interactions:

    Search GeneGlobe Interaction Network for PPCS

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for PPCS (Q9HAB8³ ENSP00000361642⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 48)

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

Drugs & Compounds
for PPCS gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Transcripts
for PPCS gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Expression
for PPCS gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPCS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGGATTAAAA

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for PPCS OriGene qSTAR qPCR primer pairs in human, mouse for PPCS
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPCS
		QuantiTect SYBR Green Assays in human, mouse, rat PPCS
		QuantiFast Probe-based Assays in human, mouse, rat PPCS

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPCS

Orthologs
for PPCS gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

Paralogs
for PPCS gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for PPCS gene

Find genes that share paralogs with PPCS           About GenesLikeMe


1 Pseudogenes.org Pseudogene for PPCS
PGOHUM00000243388

Genomic Variants
for PPCS gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for PPCS (see all 58)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs799906451,2	C,F	--	42924003(+)	GGTAGG/ATGTGG	2	--	int1		1		NA	120
rs1853833191,2		--	42924033(+)	GAACCC/TTCAGG	2	--	int1		0	--	--	--	--
rs1151488491,2	F	--	42924046(+)	TTCTTA/TGTCAT	2	--	int1		1		WA	118
rs1458620691,2		--	42924052(+)	GTCATG/TTATTG	2	--	int1		0	--	--	--	--
rs1386942981,2		--	42924226(+)	AATAAA/GTAAGT	2	--	int1		0	--	--	--	--
rs1492391981,2		--	42924262(+)	ATAAAG/TGCTAA	2	--	int1		0	--	--	--	--
rs795260211,2	C,F	--	42924306(+)	GATCCC/TTATCA	2	--	int1		1		NA	120
rs1898070871,2		--	42924334(+)	TAGGGC/TAAAGT	2	--	int1		0	--	--	--	--
rs1438370541,2		--	42924395(+)	TTTATC/TCCACA	2	--	int1		0	--	--	--	--
rs1820991401,2		--	42924433(+)	AAGCAA/GCTGAA	2	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for PPCS (42921788 - 42939056 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for PPCS:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv870704	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing PPCS

DNA2.0 Custom Variant and Variant Library Synthesis for PPCS

Disorders / Diseases
for PPCS gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

Publications
for PPCS gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

1. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. (PubMed id 11923312)^{1, 2, 3} Daugherty M.... Osterman A. (J. Biol. Chem. 2002)
2. Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution. (PubMed id 12906824)^{1, 2, 9} Manoj N.... Ealick S.E. (Structure 2003)
3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (Nature 2006)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
6. Kinetic characterization of human phosphopantothenoylcysteine synthetase. (PubMed id 19683078)^{1, 9} Yao J. and Dotson G.D. (Biochim. Biophys. Acta 2009)
7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)¹ Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
9. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)² Bienvenut W.V....Giglione C. (amp 2012)
10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)² Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

External Searches for PPCS gene

Genome Databases showing PPCS gene

Other Databases showing PPCS gene

Specialized Databases showing PPCS gene

Products
for PPCS gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section