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PPCS Gene(Protein Coding)

Phosphopantothenoylcysteine Synthetase

GCID:
GC01P042456
GIFtS:
57
Genes Participants
UDN Logo

Aliases for PPCS Gene

Aliases for PPCS Gene

  • Phosphopantothenoylcysteine Synthetase 2 3 4 5
  • PPC Synthetase 4
  • EC 6.3.2.5 4
  • COAB 4

External Ids for PPCS Gene

Previous GeneCards Identifiers for PPCS Gene

  • GC01P042592
  • GC01P042694
  • GC01P042921
  • GC01P041042

Summaries for PPCS Gene

Entrez Gene Summary for PPCS Gene

  • Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PPCS Gene

PPCS (Phosphopantothenoylcysteine Synthetase) is a Protein Coding gene. Among its related pathways are Metabolism and Pantothenate and CoA biosynthesis. GO annotations related to this gene include phosphopantothenate--cysteine ligase activity.

UniProtKB/Swiss-Prot for PPCS Gene

  • Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4-phosphopantothenate to form 4-phosphopantothenoylcysteine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPCS Gene

Genomics for PPCS Gene

Products:

  1. Regulatory Element

Regulatory Elements for PPCS Gene

Enhancers for PPCS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPCS on UCSC Golden Path with GeneCards custom track

Promoters for PPCS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPCS on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PPCS gene promoter:

Genomic Location for PPCS Gene

Chromosome:
1
Start:
42,456,117 bp from pter
End:
42,473,385 bp from pter
Size:
17,269 bases
Orientation:
Plus strand

Genomic View for PPCS Gene

Genes around PPCS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPCS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPCS Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PPCS Gene

Proteins for PPCS Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PPCS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAB8-PPCS_HUMAN
    Recommended name:
    Phosphopantothenate--cysteine ligase
    Protein Accession:
    Q9HAB8
    Secondary Accessions:
    • Q3KQT2
    • Q5VVM0

    Protein attributes for PPCS Gene

    Size:
    311 amino acids
    Molecular mass:
    34005 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • The mammalian enzyme has a preference for ATP over CTP, in contrast to the E.coli ortholog.
    SequenceCaution:
    • Sequence=BAB13931.1; Type=Frameshift; Positions=282; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPCS Gene

    Alternative splice isoforms for PPCS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPCS Gene

Proteomics data for PPCS Gene at MOPED

Protein Expression for PPCS Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PPCS Gene

  • Ubiquitination at Lys 224
  • Modification sites at PhosphoSitePlus

Other Protein References for PPCS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PPCS Gene

Domains & Families for PPCS Gene

Protein Domains for PPCS Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PPCS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HAB8

UniProtKB/Swiss-Prot:

PPCS_HUMAN :
  • Belongs to the PPC synthetase family.
Family:
  • Belongs to the PPC synthetase family.
genes like me logo Genes that share domains with PPCS: view

No data available for Gene Families for PPCS Gene

Function for PPCS Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for PPCS Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CTP + (R)-4-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4-phosphopantothenoyl)-L-cysteine.
UniProtKB/Swiss-Prot Function:
Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4-phosphopantothenate to form 4-phosphopantothenoylcysteine.

Enzyme Numbers (IUBMB) for PPCS Gene

Phenotypes for PPCS Gene

GenomeRNAi human phenotypes for PPCS:
genes like me logo Genes that share phenotypes with PPCS: view

Animal Model Products

miRNA for PPCS Gene

miRTarBase miRNAs that target PPCS

Inhibitory RNA Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPCS Gene

Localization for PPCS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPCS Gene COMPARTMENTS Subcellular localization image for PPCS gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
mitochondrion 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPCS Gene

Pathways & Interactions for PPCS Gene

genes like me logo Genes that share pathways with PPCS: view

UniProtKB/Swiss-Prot Q9HAB8-PPCS_HUMAN

  • Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.

Interacting Proteins for PPCS Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361642%0d%0a9606.ENSP00000239231%0d%0a9606.ENSP00000367727%0d%0a9606.ENSP00000302108%0d%0a9606.ENSP00000313377%0d%0a9606.ENSP00000359539%0d%0a
Selected Interacting proteins: ENSP00000361642 Q9HAB8-PPCS_HUMAN for PPCS Gene via STRING I2D

Gene Ontology (GO) - Biological Process for PPCS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0009108 coenzyme biosynthetic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with PPCS: view

No data available for SIGNOR curated interactions for PPCS Gene

Drugs & Compounds for PPCS Gene

Products:

  1. Drug

(6) Drugs for PPCS Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
L-Cysteine Approved Nutra 0
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0

(4) Additional Compounds for PPCS Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Phosphopantothenoylcysteine
  • (R)-4'-phospho-N-pantothenoyl-L-cysteine
  • (R)-N-[N-[2-hydroxy-3,3-dimethyl-1-oxo-4-(phosphonooxy)butyl]-b-alanyl]-L-Cysteine
  • (R)-N-[N-[2-hydroxy-3,3-dimethyl-1-oxo-4-(phosphonooxy)butyl]-beta-alanyl]-L-Cysteine
  • 4'-P-N-Pantothenoylcysteine
  • 4'-Phospho-N-pantothenoylcysteine
 7196-09-0
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
 63-37-6
D-4'-Phosphopantothenate
  • (R)-4'-phosphopantothenate
  • 4'-P-Pantothenate
  • 4'-Phosphopantothenate
  • D-4'-Phosphopantothenate
  • D-4'-Phosphopantothenic acid
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
 7664-38-2
genes like me logo Genes that share compounds with PPCS: view

Transcripts for PPCS Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for PPCS Gene

(8) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(289) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPCS Gene

Phosphopantothenoylcysteine synthetase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPCS Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e
SP1: - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6:
SP7: - -

Relevant External Links for PPCS Gene

GeneLoc Exon Structure for
PPCS
ECgene alternative splicing isoforms for
PPCS

Expression for PPCS Gene

Products:

  1. Primer

mRNA expression in normal human tissues for PPCS Gene

mRNA expression in normal human tissues for PPCS Gene
mRNA expression by BioGPS for PPCS GenemRNA expression by GTEx for PPCS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPCS Gene

This gene is overexpressed in Oral epithelium (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPCS Gene



SOURCE GeneReport for Unigene cluster for PPCS Gene Hs.706662

genes like me logo Genes that share expression patterns with PPCS: view

Protein tissue co-expression partners for PPCS Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PPCS Gene

Orthologs for PPCS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPCS Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia PPCS 35
  • 88 (n)
  • 86.17 (a)
PPCS 36
  • 86 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ppcs 35
  • 85.53 (n)
  • 87.46 (a)
Ppcs 16
Ppcs 36
  • 87 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia PPCS 35
  • 90.87 (n)
  • 89 (a)
PPCS 36
  • 98 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Ppcs 35
  • 85.32 (n)
  • 88.1 (a)
cow
(Bos Taurus)
 Mammalia PPCS 36
  • 89 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia PPCS 36
  • 70 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia PPCS 36
  • 69 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves PPCS 35
  • 67.64 (n)
  • 68.5 (a)
PPCS 36
  • 58 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ppcs 35
  • 63.88 (n)
  • 64.81 (a)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.15423 35
zebrafish
(Danio rerio)
 Actinopterygii ppcs 35
  • 59.33 (n)
  • 58.67 (a)
ppcs 36
  • 54 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP004311 35
  • 50.82 (n)
  • 42.96 (a)
fruit fly
(Drosophila melanogaster)
 Insecta Ppcs 35
  • 50.12 (n)
  • 41.96 (a)
Ppcs 36
  • 38 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea Y71H2AM.6 35
  • 49.8 (n)
  • 46.96 (a)
Y71H2AM.6 36
  • 38 (a)
 OneToOne
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AGR391W 35
  • 50.86 (n)
  • 45.02 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0E08757g 35
  • 48.13 (n)
  • 44.03 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes CAB2 35
  • 46.54 (n)
  • 43.02 (a)
CAB2 36
  • 30 (a)
 OneToOne
CAB2 38
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT5G02080 35
  • 50.34 (n)
  • 47.77 (a)
rice
(Oryza sativa)
 Liliopsida Os08g0176100 35
  • 51.23 (n)
  • 46.67 (a)
bread mold
(Neurospora crassa)
 Ascomycetes NCU09090 35
  • 52.32 (n)
  • 48.52 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes SPCC4B3.18 35
  • 47.65 (n)
  • 44.3 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 38 (a)
 OneToOne
Species with no ortholog for PPCS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPCS Gene

ENSEMBL:
Gene Tree for PPCS (if available)
TreeFam:
Gene Tree for PPCS (if available)

Paralogs for PPCS Gene

Pseudogenes.org Pseudogenes for PPCS Gene

genes like me logo Genes that share paralogs with PPCS: view

No data available for Paralogs for PPCS Gene

Variants for PPCS Gene

Sequence variations from dbSNP and Humsavar for PPCS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9787162 -- 42,460,017(+) ACAGA(G/T)AAAAT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs11316113 -- 42,459,178(+) TTTTT(-/T)GTGAG intron-variant
rs16829554 -- 42,460,695(+) AGTCA(A/G)CTTAG intron-variant, utr-variant-3-prime
rs34750353 -- 42,458,517(+) TACCC(-/C)TGCCT intron-variant
rs34214064 -- 42,460,657(+) TGAGG(-/G)ATGCA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PPCS Gene

Variant ID Type Subtype PubMed ID
nsv870704 CNV Gain 21882294

Variation tolerance for PPCS Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPCS Gene

HapMap Linkage Disequilibrium report
PPCS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPCS Gene

Disorders for PPCS Gene

Relevant External Links for PPCS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPCS

No disorders were found for PPCS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPCS Gene

Publications for PPCS Gene

  1. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. (PMID: 11923312) Daugherty M. … Osterman A. (J. Biol. Chem. 2002) 2 3 4 67
  2. Kinetic characterization of human phosphopantothenoylcysteine synthetase. (PMID: 19683078) Yao J. … Dotson G.D. (Biochim. Biophys. Acta 2009) 3 23
  3. Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution. (PMID: 12906824) Manoj N. … Ealick S.E. (Structure 2003) 3 23
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for PPCS Gene

Sources for PPCS Gene

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