Aliases for PPCS Gene
Aliases for PPCS Gene
External Ids for PPCS Gene
- HGNC: 25686
- Entrez Gene: 79717
- Ensembl: ENSG00000127125
- OMIM: 609853
- UniProtKB: Q9HAB8
Previous GeneCards Identifiers for PPCS Gene
- GC01P042592
- GC01P042694
- GC01P042921
- GC01P041042
Summaries for PPCS Gene
-
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PPCS Gene
PPCS (Phosphopantothenoylcysteine Synthetase) is a Protein Coding gene. Diseases associated with PPCS include Pleural Disease. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism. Gene Ontology (GO) annotations related to this gene include phosphopantothenate--cysteine ligase activity.
UniProtKB/Swiss-Prot for PPCS Gene
-
Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4-phosphopantothenate to form 4-phosphopantothenoylcysteine.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPCS Gene
Genomics for PPCS Gene
GeneHancer (GH) Regulatory Elements for PPCS Gene
Regulatory Element Products
Genomic Locations for PPCS Gene
- chr1:42,456,117-42,473,385
- (GRCh38/hg38)
- Size:
- 17,269 bases
- Orientation:
- Plus strand
- chr1:42,921,788-42,939,056
- (GRCh37/hg19)
Genomic View for PPCS Gene
- Cytogenetic band:
-
- 1p34.2 by Ensembl
- 1p34.2 by Entrez Gene
- 1p34.2 by HGNC


RefSeq DNA sequence for PPCS Gene
Proteins for PPCS Gene
-
Protein details for PPCS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HAB8-PPCS_HUMAN
- Recommended name:
- Phosphopantothenate--cysteine ligase
- Protein Accession:
- Q9HAB8
- Q3KQT2
- Q5VVM0
Protein attributes for PPCS Gene
- Size:
- 311 amino acids
- Molecular mass:
- 34005 Da
- Quaternary structure:
-
- Homodimer.
- Miscellaneous:
-
- The mammalian enzyme has a preference for ATP over CTP, in contrast to the E.coli ortholog.
- SequenceCaution:
-
- Sequence=BAB13931.1; Type=Frameshift; Positions=282; Evidence={ECO:0000305};
Protein Expression for PPCS Gene
Post-translational modifications for PPCS Gene
- Ubiquitination at Lys224
Other Protein References for PPCS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PPCS
-
Abcam antibodies for PPCS
- Invitrogen Antibodies for PPCS
- GeneTex PPCS antibody for PPCS
Protein Products
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-
Abcam proteins for PPCS
Assay Products
No data available for DME Specific Peptides for PPCS Gene
Domains & Families for PPCS Gene
Gene Families for PPCS Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PPCS Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PPCS Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9HAB8- Family:
-
- Belongs to the PPC synthetase family.
Function for PPCS Gene
Molecular function for PPCS Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- CTP + (R)-4-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4-phosphopantothenoyl)-L-cysteine.
- UniProtKB/Swiss-Prot Function:
- Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4-phosphopantothenate to form 4-phosphopantothenoylcysteine.
Enzyme Numbers (IUBMB) for PPCS Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004632 | phosphopantothenate--cysteine ligase activity | TAS | -- |
GO:0016874 | ligase activity | IEA | -- |
Phenotypes for PPCS Gene
- GenomeRNAi human phenotypes for PPCS:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for PPCS gene
-
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CRISPR Products
-
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- Overview of 128 available PPCS gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for PPCS Gene
- miRTarBase miRNAs that target PPCS
miRNA Products
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Inhibitory RNA Products
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Clone Products
-
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PPCS
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PPCS
-
ViGene Biosciences adenoviral particle packaged cDNA for PPCS gene
-
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No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPCS Gene
Localization for PPCS Gene
- Mitochondria (2)
- Nucleoli fibrillar center (2)
- Nucleus (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0070062 | extracellular exosome | IDA,HDA | 23376485 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPCS Gene
Pathways & Interactions for PPCS Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism of water-soluble vitamins and cofactors | ||
2 | Metabolism |
.37
|
|
3 | Pantothenate and CoA biosynthesis |
Pathways by source for PPCS Gene
1 BioSystems pathway for PPCS Gene
2 KEGG pathways for PPCS Gene
UniProtKB/Swiss-Prot Q9HAB8-PPCS_HUMAN
- Pathway: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.
Interacting Proteins for PPCS Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0009108 | coenzyme biosynthetic process | TAS | -- |
GO:0015937 | coenzyme A biosynthetic process | IEA | -- |
No data available for SIGNOR curated interactions for PPCS Gene
Drugs & Compounds for PPCS Gene
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
4-Phosphopantothenoylcysteine |
|
7196-09-0 |
|
|||
D-4'-Phosphopantothenate |
|
|
||||
pyrophosphate |
|
14000-31-8 |
|
Transcripts for PPCS Gene
mRNA/cDNA for PPCS Gene
- (8) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (289) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PPCS Gene
CRISPR Products
-
OriGene CRISPR knockouts for PPCS
- genomics-online: gRNA clones - Search results for 128 available PPCS gene related products
- Overview of 128 available PPCS gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPCS
- GenScript: Design CRISPR guide RNA sequences for PPCS
miRNA Products
- Search ViGene Biosciences for PPCS
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PPCS
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- genomics-online: shRNA clones - Search results for 128 available PPCS gene related products
- Overview of 128 available PPCS gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PPCS gene
Clone Products
-
OriGene ORF clones in human for PPCS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PPCS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPCS
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PPCS
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||
SP7: | - | - |
Expression for PPCS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Intestine (Gastrointestinal Tract)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Stomach (Gastrointestinal Tract)
-
Adipose (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPCS Gene
NURSA nuclear receptor signaling pathways regulating expression of PPCS Gene:
PPCSSOURCE GeneReport for Unigene cluster for PPCS Gene:
Hs.706662Evidence on tissue expression from TISSUES for PPCS Gene
- Nervous system(4.8)
- Liver(4.4)
- Lung(2.6)
- Blood(2.2)
- Muscle(2.2)
- Pancreas(2.2)
Primer Products
-
OriGene qPCR primer pairs for PPCS
-
OriGene qPCR primer pairs and template standards for PPCS
- genomics-online: primer clones - Search results for 128 available PPCS gene related products
- Overview of 128 available PPCS gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPCS Gene
Orthologs for PPCS Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PPCS 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | PPCS 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | PPCS 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Ppcs 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Ppcs 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | PPCS 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | PPCS 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | PPCS 33 34 |
|
||
tropical clawed frog (Silurana tropicalis) |
Amphibia | ppcs 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.15423 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | ppcs 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004311 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Ppcs 33 34 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | Y71H2AM.6 33 34 |
|
||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGR391W 33 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E08757g 33 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CAB2 33 34 36 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G02080 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os08g0176100 33 |
|
||
bread mold (Neurospora crassa) |
Ascomycetes | NCU09090 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPCC4B3.18 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for PPCS was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PPCS Gene
Pseudogenes.org Pseudogenes for PPCS Gene
No data available for Paralogs for PPCS Gene
Variants for PPCS Gene
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000014577 | -- | 42,460,994(+) | G/A | 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant | |
rs1000283476 | -- | 42,468,105(+) | A/C | genic_downstream_transcript_variant, intron_variant | |
rs1000397799 | -- | 42,467,837(+) | T/C | genic_downstream_transcript_variant, intron_variant | |
rs1000445416 | -- | 42,465,585(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
rs1000546667 | -- | 42,456,445(+) | T/C/G | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant |
Additional Variant Information for PPCS Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PPCS
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPCS Gene
Disorders for PPCS Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
pleural disease |
|
|
Additional Disease Information for PPCS
No data available for UniProtKB/Swiss-Prot and Genatlas for PPCS Gene
Publications for PPCS Gene
- Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution. (PMID: 12906824) Manoj N … Ealick SE (Structure (London, England : 1993) 2003) 3 4 22 58
- Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. (PMID: 11923312) Daugherty M … Osterman A (The Journal of biological chemistry 2002) 2 3 4 58
- Kinetic characterization of human phosphopantothenoylcysteine synthetase. (PMID: 19683078) Yao J … Dotson GD (Biochimica et biophysica acta 2009) 3 22 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for PPCS Gene
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- Invitrogen Antibodies for PPCS
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- VectorBuilder custom plasmid, inducible vectors for PPCS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPCS
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 14 available PPCS Antibodies ranked by validation data
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- Overview of 128 available PPCS gene related products
Sources for PPCS Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
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