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Aliases for PPBP Gene

Aliases for PPBP Gene

  • Pro-Platelet Basic Protein 2 3 5
  • Connective Tissue-Activating Peptide III 2 3
  • Chemokine (C-X-C Motif) Ligand 7 2 3
  • Macrophage-Derived Growth Factor 3 4
  • Leukocyte-Derived Growth Factor 3 4
  • C-X-C Motif Chemokine 7 3 4
  • Platelet Basic Protein 2 3
  • Beta-Thromboglobulin 2 3
  • THBGB1 3 4
  • CTAP3 3 4
  • CXCL7 3 4
  • SCYB7 3 4
  • LDGF 3 4
  • MDGF 3 4
  • TGB1 3 4
  • PBP 3 4
  • Small Inducible Cytokine Subfamily B, Member 7 3
  • Neutrophil-Activating Peptide-2 2
  • Low-Affinity Platelet Factor IV 3
  • Neutrophil-Activating Peptide 2 3
  • Small Inducible Cytokine B7 3
  • Small-Inducible Cytokine B7 4
  • Thromboglobulin, Beta-1 3
  • CXC Chemokine Ligand 7 3
  • Thrombocidin 1 3
  • Thrombocidin 2 3
  • CTAP-III 3
  • Beta-TG 3
  • CTAPIII 3
  • LA-PF4 3
  • NAP-2 3
  • B-TG1 3
  • THBGB 3
  • TC1 3
  • TC2 3
  • TGB 3

External Ids for PPBP Gene

Previous HGNC Symbols for PPBP Gene

  • THBGB1

Previous GeneCards Identifiers for PPBP Gene

  • GC04M074841
  • GC04M075092
  • GC04M075253
  • GC04M075319
  • GC04M075217
  • GC04M070663

Summaries for PPBP Gene

Entrez Gene Summary for PPBP Gene

  • The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014]

GeneCards Summary for PPBP Gene

PPBP (Pro-Platelet Basic Protein) is a Protein Coding gene. Diseases associated with PPBP include Erythromelalgia and Colloid Adenoma. Among its related pathways are Phospholipase-C Pathway and Peptide ligand-binding receptors. GO annotations related to this gene include growth factor activity and glucose transmembrane transporter activity. An important paralog of this gene is CXCL1.

UniProtKB/Swiss-Prot for PPBP Gene

  • LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.

Gene Wiki entry for PPBP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPBP Gene

Genomics for PPBP Gene

Regulatory Elements for PPBP Gene

Enhancers for PPBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G073891 1.1 FANTOM5 Ensembl ENCODE 10.2 +96.2 96210 0.8 SCRT2 CEBPB EP300 CXCL3 CXCL8 PF4V1 EREG MTHFD2L PPBP CXCL2 CXCL1 HNRNPA1P55
GH04G074036 1 ENCODE 10.4 -50.4 -50369 3.3 PKNOX1 ATF1 CREB3L1 SIN3A ZNF766 GLIS2 GATA2 ZNF263 SP3 REST PPBP CXCL2 LOC105377275 RN7SL218P
GH04G073843 1 Ensembl ENCODE 10 +143.9 143850 1.7 PKNOX1 JUN CEBPB EP300 FOSL1 ZNF316 JUND MAFF ATF3 GATA2 PPBP MTHFD2L CXCL8 PF4V1 PPBPP1 CXCL6
GH04G074016 0.8 FANTOM5 ENCODE 11.7 -28.1 -28095 0.3 MTA2 TBX21 SPI1 CXCL2 CXCL3 EREG CXCL8 MTHFD2L PPBP RN7SL218P LOC105377275
GH04G073965 0.6 ENCODE 12.3 +23.1 23065 0.1 CTCF MAZ ZNF654 ZNF394 REST ZNF398 ZNF2 RAD21 SCRT2 ZBTB33 PPBP PF4V1 MTHFD2L PIR32408 PF4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPBP on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PPBP gene promoter:

Genomic Location for PPBP Gene

Chromosome:
4
Start:
73,986,439 bp from pter
End:
73,988,197 bp from pter
Size:
1,759 bases
Orientation:
Minus strand

Genomic View for PPBP Gene

Genes around PPBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPBP Gene

Proteins for PPBP Gene

  • Protein details for PPBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02775-CXCL7_HUMAN
    Recommended name:
    Platelet basic protein
    Protein Accession:
    P02775
    Secondary Accessions:
    • B2R5F3
    • Q6IBJ8

    Protein attributes for PPBP Gene

    Size:
    128 amino acids
    Molecular mass:
    13894 Da
    Quaternary structure:
    • Beta-thromboglobulin is a homotetramer.

    Three dimensional structures from OCA and Proteopedia for PPBP Gene

neXtProt entry for PPBP Gene

Post-translational modifications for PPBP Gene

  • NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils.
  • NAP-2(73) and NAP-2(74) seem not be produced by proteolytical processing of secreted precursors but are released in an active form from platelets.
  • Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets along with platelet factor 4 and platelet-derived growth factor.
  • Proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III (CTAP-III) (low-affinity platelet factor IV (LA-PF4)).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPBP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PPBP

Assay Products

  • Cloud-Clone Corp. Assay Kits for PPBP

No data available for DME Specific Peptides for PPBP Gene

Domains & Families for PPBP Gene

Gene Families for PPBP Gene

Suggested Antigen Peptide Sequences for PPBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02775

UniProtKB/Swiss-Prot:

CXCL7_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with PPBP: view

Function for PPBP Gene

Molecular function for PPBP Gene

GENATLAS Biochemistry:
connective tissue activating peptide III,including platelet basic protein,precursor of beta thromboglobulin and neutrophil activating protein 2 (see IMC2@)
UniProtKB/Swiss-Prot Function:
LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.

Gene Ontology (GO) - Molecular Function for PPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005355 glucose transmembrane transporter activity TAS 4005226
GO:0008009 chemokine activity IBA --
GO:0008083 growth factor activity IEA --
GO:0045236 CXCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with PPBP: view
genes like me logo Genes that share phenotypes with PPBP: view

Animal Model Products

CRISPR Products

miRNA for PPBP Gene

miRTarBase miRNAs that target PPBP

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PPBP
  • Applied Biological Materials Clones for PPBP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPBP Gene

Localization for PPBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPBP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPBP gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytosol 2
lysosome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA,IEA --
GO:0031093 platelet alpha granule lumen TAS --
GO:1904724 tertiary granule lumen TAS --
genes like me logo Genes that share ontologies with PPBP: view

Pathways & Interactions for PPBP Gene

genes like me logo Genes that share pathways with PPBP: view

Gene Ontology (GO) - Biological Process for PPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002523 leukocyte migration involved in inflammatory response IEA --
GO:0002576 platelet degranulation TAS --
GO:0006935 chemotaxis IEA --
GO:0006952 defense response IEA --
GO:0006954 inflammatory response IBA --
genes like me logo Genes that share ontologies with PPBP: view

No data available for SIGNOR curated interactions for PPBP Gene

Drugs & Compounds for PPBP Gene

(41) Drugs for PPBP Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
Ethanesulfonic Acid Experimental Pharma Target 0

(49) Additional Compounds for PPBP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PPBP: view

Transcripts for PPBP Gene

mRNA/cDNA for PPBP Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(44) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPBP Gene

Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PPBP
  • Applied Biological Materials Clones for PPBP

Alternative Splicing Database (ASD) splice patterns (SP) for PPBP Gene

No ASD Table

Relevant External Links for PPBP Gene

GeneLoc Exon Structure for
PPBP
ECgene alternative splicing isoforms for
PPBP

Expression for PPBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPBP Gene

This gene is overexpressed in Whole Blood (x43.6) and Spleen (x5.8).

Protein differential expression in normal tissues from HIPED for PPBP Gene

This gene is overexpressed in Platelet (32.3) and Peripheral blood mononuclear cells (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPBP Gene



Protein tissue co-expression partners for PPBP Gene

NURSA nuclear receptor signaling pathways regulating expression of PPBP Gene:

PPBP

SOURCE GeneReport for Unigene cluster for PPBP Gene:

Hs.2164

Evidence on tissue expression from TISSUES for PPBP Gene

  • Blood(4.8)
  • Liver(4.3)
  • Bone marrow(2.8)
  • Heart(2.4)
  • Spleen(2)
genes like me logo Genes that share expression patterns with PPBP: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPBP Gene

Orthologs for PPBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPBP 34 35
  • 98.96 (n)
cow
(Bos Taurus)
Mammalia PPBP 35
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPBP 35
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppbp 35
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 50 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 44 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 37 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
OneToMany
Species where no ortholog for PPBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PPBP Gene

ENSEMBL:
Gene Tree for PPBP (if available)
TreeFam:
Gene Tree for PPBP (if available)

Paralogs for PPBP Gene

Paralogs for PPBP Gene

(9) SIMAP similar genes for PPBP Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PPBP Gene

genes like me logo Genes that share paralogs with PPBP: view

Variants for PPBP Gene

Sequence variations from dbSNP and Humsavar for PPBP Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1001814023 -- 73,986,297(+) TCATA(C/T)TACAT downstream-variant-500B
rs1002657820 -- 73,988,627(+) TTCAT(C/G)AATGT upstream-variant-2KB
rs1002693408 -- 73,987,108(+) AACCA(A/G)CCTTC utr-variant-3-prime
rs1002697696 -- 73,988,189(+) GATAA(A/G)TGGCT utr-variant-5-prime
rs1003223456 -- 73,987,822(+) GTGAC(C/G)CCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPBP Gene

Variant ID Type Subtype PubMed ID
esv3575747 CNV gain 25503493
nsv1001725 CNV gain 25217958
nsv1004768 CNV gain 25217958
nsv1006029 CNV gain 25217958
nsv525980 CNV gain 19592680

Variation tolerance for PPBP Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPBP Gene

Disorders for PPBP Gene

MalaCards: The human disease database

(12) MalaCards diseases for PPBP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
erythromelalgia
  • primary erythermalgia
colloid adenoma
  • macrofollicular adenoma
essential thrombocythemia
  • essential thrombocythaemia
hemorrhagic disease
  • hemorrhagic diathesis
vascular disease
  • vascular tissue disease
- elite association - COSMIC cancer census association via MalaCards
Search PPBP in MalaCards View complete list of genes associated with diseases

Relevant External Links for PPBP

Genetic Association Database (GAD)
PPBP
Human Genome Epidemiology (HuGE) Navigator
PPBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPBP
genes like me logo Genes that share disorders with PPBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPBP Gene

Publications for PPBP Gene

  1. Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4. (PMID: 1826003) Majumdar S. … Poncz M. (J. Biol. Chem. 1991) 2 3 4 22 64
  2. Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines. (PMID: 10877842) Krijgsveld J. … Dankert J. (J. Biol. Chem. 2000) 3 4 22 64
  3. Novel C-terminally truncated isoforms of the CXC chemokine beta- thromboglobulin and their impact on neutrophil functions. (PMID: 9794434) Ehlert J.E. … Brandt E. (J. Immunol. 1998) 3 4 22 64
  4. Thrombin-activated human platelets release two NAP-2 variants that stimulate polymorphonuclear leukocytes. (PMID: 8950790) Piccardoni P. … Cerletti C. (Thromb. Haemost. 1996) 3 4 22 64
  5. The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution. (PMID: 7706245) Malkowski M.G. … Edwards B.F.P. (J. Biol. Chem. 1995) 3 4 22 64

Products for PPBP Gene

  • Addgene plasmids for PPBP

Sources for PPBP Gene

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