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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPBP Gene

protein-coding   GIFtS: 62
GCID: GC04M074841

pro-platelet basic protein (chemokine (C-X-C motif) ligand...


(Previous symbol: THBGB1)
 Explore 98 diseases affiliated with
PPBP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PPBP    

Aliases
for PPBP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Pro-Platelet Basic Protein (Chemokine (C-X-C Motif) Ligand 7)1 2     B-TG12
CXCL71 2 3 5     B-TG12
TGB11 2 3 5     CTAP-III2
CTAP31 2 3     TC12
LDGF1 2 3     TC22
MDGF1 2 3     THBGB2
PBP1 2 3     Beta-Thromboglobulin1
SCYB71 2 3     Connective Tissue-Activating Peptide III2
THBGB11 2 3     CXC Chemokine Ligand 72
Beta-TG1 2     Low-Affinity Platelet Factor IV2
CTAPIII1 2     Neutrophil-Activating Peptide 22
LA-PF41 2     Neutrophil-Activating Peptide-22
NAP-21 2     Platelet Basic Protein2
TGB1 2     Small Inducible Cytokine B72
Leukocyte-Derived Growth Factor2 3     Small Inducible Cytokine Subfamily B, Member 72
Macrophage-Derived Growth Factor2 3     Thrombocidin 12
Small-Inducible Cytokine B72 3     Thrombocidin 22
C-X-C Motif Chemokine 72 3     Thromboglobulin, Beta-12
NAP-2-L11     SCAR105

External Ids:    HGNC: 92401   Entrez Gene: 54732   Ensembl: ENSG000001637367   OMIM: 1210105   UniProtKB: P027753   

Export aliases for PPBP gene to outside databases

Previous GC identifers: GC04M075092 GC04M075253 GC04M075319 GC04M075217 GC04M070663


Summaries
for PPBP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PPBP:
The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This
growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various
cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2
secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and
secretion of plasminogen activator by synovial cells. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: CXCL7_HUMAN, P02775
Function: LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2
secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and
secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2,
NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils.
TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is
more potent than CTAP-III desensitize chemokine-induced neutrophil activation

Gene Wiki entry for PPBP (CXCL7)


Genomic Views
for PPBP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPBP gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPBP promoter sequence
   Search SABiosciences Chromatin IP Primers for PPBP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12-q13   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q12-q13

PPBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPBP gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M074841:  view genomic region     (about GC identifiers)

Start:
 74,852,156 bp from pter      End:
 74,853,914 bp from pter
Size:
 1,759 bases      Orientation:
 minus strand

Proteins
for PPBP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CXCL7_HUMAN, P02775 (See protein sequence)
Recommended Name: Platelet basic protein precursor  
Size: 128 amino acids; 13894 Da
Subunit: Beta-thromboglobulin is a homotetramer
Subcellular location: Secreted
3 PDB 3D structures from and Proteopedia for PPBP:
1F9P (3D)        1NAP (3D)        1TVX (3D)    
Secondary accessions: B2R5F3 Q6IBJ8

Explore the universe of human proteins at neXtProt for PPBP: NX_P02775

Post-translational modifications:

  • Proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III (CTAP-III)
    • (low-affinity platelet factor IV (LA-PF4))1
  • Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets
    • along with platelet factor 4 and platelet-derived growth factor1
  • NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils1
  • NAP-2(73) and NAP-2(74) seem not be produced by proteolytical processing of secreted precursors but are released in an
    • active form from platelets1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P02775

    • PPBP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002695.1  
    ENSEMBL proteins: 
     ENSP00000296028  
    Reactome Protein details: P02775
    Human Recombinant Protein Products: 
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    Novus Biologicals PPBP Proteins
    Novus Biologicals PPBP Lysates
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    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0031093platelet alpha granule lumen TAS--


    PPBP for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for PPBP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PPBP for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001811 Chemokine_IL8-like_dom
     IPR027223 PPBP
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P02775

    ProtoNet protein and cluster: P02775

    1 Blocks protein family: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: CXCL7_HUMAN, P02775
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    Function
    for PPBP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CXCL7_HUMAN, P02775
    Function: LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2
    secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and
    secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2,
    NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils.
    TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is
    more potent than CTAP-III desensitize chemokine-induced neutrophil activation

         Genatlas biochemistry entry for PPBP:
    connective tissue activating peptide III,including platelet basic protein,precursor of beta thromboglobulin and
    neutrophil activating protein 2 (see IMC2@)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPBP
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PPBP:
    hsa-miR-576-5p hsa-miR-1267
    SwitchGear 3'UTR luciferase reporter plasmid: PPBP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPBP (see all 7)
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    OriGene siRNA: PPBP
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005355glucose transmembrane transporter activity TAS4005226
    GO:0008009chemokine activity IEA--
    GO:0008083growth factor activity IEA--


    PPBP for ontologies           About GeneDecksing



    Pathways & Interactions
    for PPBP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    4Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    		G alpha (i) signalling events0.44
    5TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JAK-STAT Pathway0.57
    		MAPK Family Pathway0.60
    		JNK Pathway0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPBP (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    5/12        Reactome Pathways for PPBP (see all 12)
        GPCR downstream signaling
    Hemostasis
    Peptide ligand-binding receptors
    Signaling by GPCR
    GPCR ligand binding


    2         Kegg Pathways  (Kegg details for PPBP):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    PPBP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/205 Interacting proteins for PPBP (P027752, 3 ENSP000002960284) via UniProtKB, MINT, STRING, and/or I2D (see all 205)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFNA1P208272, 3, ENSP000003573924MINT-64465 MINT-8254952 I2D: score=5 STRING: ENSP00000357392
    DMWDQ090192, 3, ENSP000002702234MINT-64078 I2D: score=4 STRING: ENSP00000270223
    MOB3BQ86TA12, 3, ENSP000002622444MINT-8263291 I2D: score=2 STRING: ENSP00000262244
    NDUFB11Q9NX142, 3, ENSP000002760624MINT-8263610 I2D: score=2 STRING: ENSP00000276062
    CELF1Q928792, 3MINT-65065 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0006935chemotaxis IEA--
    GO:0006955immune response IEA--
    GO:0007596blood coagulation TAS--
    GO:0015758glucose transport TAS4005226


    PPBP for ontologies           About GeneDecksing



    Drugs & Compounds
    for PPBP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPBP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPBP

    1 HMDB Compound for PPBP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    1 DrugBank Compound for PPBP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ethanesulfonic Acid-- --target--17139284 17016423

    10/89 Novoseek chemical compound relationships for PPBP gene (see all 89)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ppbp 79.7 7 16739131 (2), 20147583 (1), 7698025 (1), 10343098 (1) (see all 5)
    groalpha 78.2 20 16687566 (3), 8702798 (3), 10540194 (2), 11023662 (2) (see all 8)
    grobeta 73.7 8 8702798 (4)
    txb2 73.5 86 9140910 (6), 8045831 (5), 2151948 (3), 9260099 (3) (see all 34)
    rantes 70.8 50 7515718 (2), 7531729 (2), 14516451 (2), 10988316 (2) (see all 32)
    fibrinogen 62.8 53 12222758 (2), 12457211 (2), 10467790 (2), 8864251 (2) (see all 32)
    6-ketoprostaglandin f1alpha 57.2 12 18521540 (2), 1840363 (1), 15932816 (1), 1831734 (1) (see all 8)
    heparin 55.4 33 12415589 (4), 11227969 (2), 9268188 (2), 16675258 (2) (see all 21)
    cloricromene 55.3 2 8219005 (1), 1833211 (1)
    aspirin 55.3 35 8759084 (3), 8342880 (3), 7946179 (2), 8883266 (2) (see all 17)

    Search CenterWatch for drugs/clinical trials and news about PPBP / CXCL7 

    Transcripts
    for PPBP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PPBP gene: 
    NM_002704.3  

    Unigene Cluster for PPBP:

    Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
    Hs.2164  [show with all ESTs]
    Unigene Representative Sequence: NM_002704
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000296028(uc003hhj.3)

    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK312166.1 BC028217.1 CR456805.1 M54995.1 

    1 DOTS entry:

    DT.214346 

    24/44 AceView cDNA sequences (see all 44):

    R64130 H93019 W67149 CB112845 BX281396 NM_002704 AA884049 AA952921 
    R29543 CR456805 H54668 BI907201 W93309 BX443846 BC028217 W92812 
    AI581312 BQ447470 H94245 BG058621 AI128304 M54995 BF002352 W67392 

    GeneLoc Exon Structure


    Expression
    for PPBP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTATAAAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PPBP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    AdiposeThoracic Perivascular AdiposeAdipose
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PPBP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPBP

    SOURCE GeneReport for Unigene cluster: Hs.2164
        SABiosciences Expression via Pathway-Focused PCR Arrays including PPBP: 
              Angiogenic Growth Factors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat
              Cardiotoxicity in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for PPBP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PPBP gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    		 Uncharacterized protein
    		 37(a)
    		 1 → many
    		 4(52472071-52473367)


    ENSEMBL Gene Tree for PPBP (if available)
    TreeFam Gene Tree for PPBP (if available) 

    Paralogs
    for PPBP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPBP gene
    CXCL32  CXCL52  PF42  CXCL12  PF4V12  IL82  CXCL22  CXCL62  
    9 SIMAP similar genes for PPBP using alignment to 1 protein entry:     CXCL7_HUMAN:
    CXCL5    CXCL1    CXCL3    CXCL9    PF4    CXCL2
    IL8    PF4V1    CXCL6

    PPBP for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PPBP
    PGOHUM00000245591


    Genomic Variants
    for PPBP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPBP
    DNA2.0 Custom Variant and Variant Library Synthesis for PPBP

    Disorders / Diseases
    for PPBP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PPBP for disorders           About GeneDecksing

    OMIM gene information: 121010   
    OMIM disorders: 613726  
    20/98 diseases for PPBP (see all 98):    About MalaCards
    spinocerebellar ataxia, autosomal recessive, 10    disseminated intravascular coagulation    heparin-induced thrombocytopenia    deep vein thrombosis
    steroid-resistant nephrotic syndrome    spinocerebellar ataxia    intermittent claudication    von willebrand's disease
    pre-eclampsia    myocardial infarction    atrial fibrillation    acute myocardial infarction
    peripheral vascular disease    allergic rhinitis    erythromelalgia    coronary heart disease
    congestive heart failure    sickle cell disease    polycythemia vera    beta thalassemia

    6 diseases from the University of Copenhagen DISEASES database for PPBP:
    Heart disease     Hypertension     Thrombocytopenia     Cerebrovascular accident
    Peripheral vascular disease     Atherosclerosis

    10/79 Novoseek disease relationships for PPBP gene (see all 79)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombocythemia essential 53.8 1 1836999 (1)
    thrombocytosis 50.7 4 1826402 (1), 12781799 (1), 1836999 (1), 17127481 (1)
    erythromelalgia 50.4 4 8883266 (3), 12781799 (1)
    essential hypertension 43.7 8 7489962 (1), 8522567 (1), 2144920 (1), 8266004 (1) (see all 7)
    thrombosis 41.6 3 11966476 (1), 20004006 (1), 9685818 (1)
    inflammation 39.3 18 10623425 (1), 11911809 (1), 9190946 (1), 17045893 (1) (see all 11)
    sclerosis systemic 39.2 1 8902649 (1)
    thrombophilia 35 1 8522567 (1)
    hemolysis 32.3 3 10886061 (1), 9304775 (1), 9335369 (1)
    thrombocytopenia 32.1 9 8695787 (2), 10468871 (1), 15884116 (1), 2142012 (1) (see all 7)

    Human Genome Epidemiology (HuGE) Navigator: PPBP (10 documents)

    Export disorders for PPBP gene to outside databases

    Publications
    for PPBP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPBP gene, integrated from 9 sources (see all 543):
    (articles sorted by number of sources associating them with PPBP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4. (PubMed id 1826003)1, 2, 3, 9 Majumdar S.... Poncz M. (1991)
    2. Novel C-terminally truncated isoforms of the CXC chemokine beta- thromboglobulin and their impact on neutrophil functions. (PubMed id 9794434)1, 2, 9 Ehlert J.E.... Brandt E. (1998)
    3. Thrombin-activated human platelets release two NAP-2 variants that stimulate polymorphonuclear leukocytes. (PubMed id 8950790)1, 2, 9 Piccardoni P....Cerletti C. (1996)
    4. Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases. (PubMed id 2406364)1, 2, 9 Walz A. and Baggiolini M. (1990)
    5. Localization of distal regulatory domains in the megakaryocyte- specific platelet basic protein/platelet factor 4 gene locus. (PubMed id 11468158)1, 2, 9 Zhang C.... Reilly M.P. (2001)
    6. The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution. (PubMed id 7706245)1, 2, 9 Malkowski M.G.... Edwards B.F.P. (1995)
    7. Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines. (PubMed id 10877842)1, 2, 9 Krijgsveld J.... Dankert J. (2000)
    8. Purification, crystallization and preliminary X-ray diffraction analysis of recombinant human neutrophil-activating peptide 2 (rhNAP- 2). (PubMed id 8034022)1, 2, 9 Kungl A.J.... Auer M. (1994)
    9. Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide. (PubMed id 2007144)1, 2, 9 Clark-Lewis I....Aebersold R. (1991)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)

    External Searches for PPBP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PPBP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5473 HGNC: 9240 AceView: PPBP Ensembl:ENSG00000163736 euGenes: HUgn5473
    ECgene: PPBP Kegg: 5473 H-InvDB: PPBP

    Other Databases showing PPBP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PPBP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPBP Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CXCL7

    Intellectual Property
    for PPBP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PPBP gene:
    Search GeneIP for patents involving PPBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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