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PPBP Gene

protein-coding   GIFtS: 62
GCID: GC04M074841

Pro-Platelet Basic Protein (Chemokine (C-X-C Motif) Ligand...


(Previous symbol: THBGB1)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pro-Platelet Basic Protein (Chemokine (C-X-C Motif) Ligand 7)1 2     B-TG12
THBGB11 2 3     Beta-TG2
CTAP32 3 5     CTAP-III2
CXCL72 3 5     CTAPIII2
SCYB72 3 5     LA-PF42
beta-thromboglobulin1 2     NAP-22
Connective Tissue-Activating Peptide III1 2     TC12
Neutrophil-Activating Peptide-21 2     TC22
Platelet Basic Protein1 2     THBGB2
Leukocyte-Derived Growth Factor2 3     CXC Chemokine Ligand 72
Macrophage-Derived Growth Factor2 3     Low-Affinity Platelet Factor IV2
Small-Inducible Cytokine B72 3     Neutrophil-Activating Peptide 22
LDGF2 3     Small Inducible Cytokine B72
MDGF2 3     Small Inducible Cytokine Subfamily B, Member 72
PBP2 3     Thrombocidin 12
TGB12 3     Thrombocidin 22
C-X-C Motif Chemokine 72 3     Thromboglobulin, Beta-12
TGB2 5     

External Ids:    HGNC: 92401   Entrez Gene: 54732   Ensembl: ENSG000001637367   OMIM: 1210105   UniProtKB: P027753   

Export aliases for PPBP gene to outside databases

Previous GC identifers: GC04M075092 GC04M075253 GC04M075319 GC04M075217 GC04M070663


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPBP Gene:
The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family.
This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate
various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation,
prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates
the formation and secretion of plasminogen activator by synovial cells. (provided by RefSeq, May 2010)

GeneCards Summary for PPBP Gene:
PPBP (pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)) is a protein-coding gene. Diseases associated with PPBP include spinocerebellar ataxia, autosomal recessive, 10, and hemoglobin e - beta-thalassemia. GO annotations related to this gene include growth factor activity and glucose transmembrane transporter activity. An important paralog of this gene is PF4.

UniProtKB/Swiss-Prot: CXCL7_HUMAN, P02775
Function: LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2
secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and
secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2,
NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for
neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules.
CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation

Gene Wiki entry for PPBP (CXCL7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPBP gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPBP promoter sequence
   Search Chromatin IP Primers for PPBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12-q13   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q12-q13

PPBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPBP gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M074841:  view genomic region     (about GC identifiers)

Start:
74,852,156 bp from pter      End:
74,853,914 bp from pter
Size:
1,759 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CXCL7_HUMAN, P02775 (See protein sequence)
Recommended Name: Platelet basic protein precursor  
Size: 128 amino acids; 13894 Da
Subunit: Beta-thromboglobulin is a homotetramer
3 PDB 3D structures from and Proteopedia for PPBP:
1F9P (3D)        1NAP (3D)        1TVX (3D)    
Secondary accessions: B2R5F3 Q6IBJ8

Explore the universe of human proteins at neXtProt for PPBP: NX_P02775

Explore proteomics data for PPBP at MOPED

Post-translational modifications: 

  • Proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III
    (CTAP-III) (low-affinity platelet factor IV (LA-PF4))1
  • Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from
    platelets along with platelet factor 4 and platelet-derived growth factor1
  • NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils1
  • NAP-2(73) and NAP-2(74) seem not be produced by proteolytical processing of secreted precursors but are released
    in an active form from platelets1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002695.1  
    ENSEMBL proteins: 
     ENSP00000296028  
    Reactome Protein details: P02775

    PPBP Human Recombinant Protein Products:

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    Novus Biologicals PPBP Lysates
    Sino Biological Recombinant Protein for PPBP
    Sino Biological Cell Lysate for PPBP
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    PPBP Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PPBP
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    PPBP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PPBP
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR001811 Chemokine_IL8-like_dom
     IPR001089 Chemokine_CXC
     IPR018048 Chemokine_CXC_CS

    Graphical View of Domain Structure for InterPro Entry P02775

    ProtoNet protein and cluster: P02775

    1 Blocks protein domain: IPB002473 Interleukin-8 signature

    UniProtKB/Swiss-Prot: CXCL7_HUMAN, P02775
    Similarity: Belongs to the intercrine alpha (chemokine CxC) family


    PPBP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CXCL7_HUMAN, P02775
    Function: LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2
    secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and
    secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2,
    NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for
    neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules.
    CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation

         Genatlas biochemistry entry for PPBP:
    connective tissue activating peptide III,including platelet basic protein,precursor of beta thromboglobulin and
    neutrophil activating protein 2 (see IMC2@)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005355glucose transmembrane transporter activity TAS4005226
    GO:0008009chemokine activity IEA--
    GO:0008083growth factor activity IEA--
         
    PPBP for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppbp):
     cellular  hematopoietic system  homeostasis/metabolism  immune system 

    PPBP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ppbptm1(KOMP)Vlcg for PPBP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPBP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPBP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPBP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPBP

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPBP:
    hsa-mir-335-5p (MIRT018016)

    Block miRNA regulation of human, mouse, rat PPBP using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate PPBP:
    hsa-miR-576-5p hsa-miR-1267
    SwitchGear 3'UTR luciferase reporter plasmidPPBP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPBP
    Predesigned siRNA for gene silencing in human, mouse, rat PPBP

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for PPBP

    Clone
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    OriGene ORF clones in mouse, rat for PPBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PPBP (NM_002704)
    Sino Biological Human cDNA Clone for PPBP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPBP

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPBP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CXCL7_HUMAN, P02775: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    nucleus1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0031093platelet alpha granule lumen TAS--

    PPBP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPBP About   (see all 19)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    Chemokine receptors bind chemokines0.81
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PPBP
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PPBP (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer


    3 Reactome Pathways for PPBP
        Platelet degranulation
    Chemokine receptors bind chemokines
    G alpha (i) signalling events


    2 Kegg Pathways  (Kegg details for PPBP):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway


    PPBP for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPBP: 
              Angiogenic Growth Factors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPBP (P027752, 3 ENSP000002960284) via UniProtKB, MINT, STRING, and/or I2D (see all 205)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFNA1P208272, 3, ENSP000003573924MINT-64465 MINT-8254952 I2D: score=5 STRING: ENSP00000357392
    DMWDQ090192, 3, ENSP000002702234MINT-64078 I2D: score=4 STRING: ENSP00000270223
    MOB3BQ86TA12, 3, ENSP000002622444MINT-8263291 I2D: score=2 STRING: ENSP00000262244
    NDUFB11Q9NX142, 3, ENSP000002760624MINT-8263610 I2D: score=2 STRING: ENSP00000276062
    CELF1Q928792, 3MINT-65065 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0006935chemotaxis ----
    GO:0006955immune response IEA--
    GO:0007596blood coagulation TAS--
    GO:0015758glucose transport TAS4005226

    PPBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPBP (CXCL7)

    1 HMDB Compound for PPBP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    1 DrugBank Compound for PPBP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ethanesulfonic Acid-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for PPBP gene (see all 89)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ppbp 79.7 7 16739131 (2), 20147583 (1), 7698025 (1), 10343098 (1) (see all 5)
    groalpha 78.2 20 16687566 (3), 8702798 (3), 10540194 (2), 11023662 (2) (see all 8)
    grobeta 73.7 8 8702798 (4)
    txb2 73.5 86 9140910 (6), 8045831 (5), 2151948 (3), 9260099 (3) (see all 34)
    rantes 70.8 50 7515718 (2), 7531729 (2), 14516451 (2), 10988316 (2) (see all 32)
    fibrinogen 62.8 53 12222758 (2), 12457211 (2), 10467790 (2), 8864251 (2) (see all 32)
    6-ketoprostaglandin f1alpha 57.2 12 18521540 (2), 1840363 (1), 15932816 (1), 1831734 (1) (see all 8)
    heparin 55.4 33 12415589 (4), 11227969 (2), 9268188 (2), 16675258 (2) (see all 21)
    cloricromene 55.3 2 8219005 (1), 1833211 (1)
    aspirin 55.3 35 8759084 (3), 8342880 (3), 7946179 (2), 8883266 (2) (see all 17)



    PPBP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PPBP gene: 
    NM_002704.3  

    Unigene Cluster for PPBP:

    Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
    Hs.2164  [show with all ESTs]
    Unigene Representative Sequence: NM_002704
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000296028(uc003hhj.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    2 qRT-PCR Assays for microRNAs that regulate PPBP:
    hsa-miR-576-5p hsa-miR-1267
    SwitchGear 3'UTR luciferase reporter plasmidPPBP 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: PPBP (NM_002704)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPBP
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PPBP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPBP
      QuantiTect SYBR Green Assays in human, mouse, rat PPBP
      QuantiFast Probe-based Assays in human, mouse, rat PPBP

    Additional mRNA sequence: 

    AK312166.1 BC028217.1 CR456805.1 M54995.1 

    1 DOTS entry:

    DT.214346 

    Selected AceView cDNA sequences (see all 44):

    BX443846 H93019 AA884049 W93309 NM_002704 CB112845 W92812 BQ447470 
    R29543 BI907201 AI581312 H54668 BC028217 W67149 BX281396 CR456805 
    R64130 AA952921 BQ016408 BG058621 BF109987 AI128304 M54995 W67392 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPBP expression in normal human tissues (normalized intensities)      PPBP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTATAAAGA
    PPBP Expression
    About this image


    PPBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Bone Marrow
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    PPBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2164
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPBP: 
              Angiogenic Growth Factors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PPBP
    OriGene qSTAR qPCR primer pairs in human, mouse for PPBP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPBP
    QuantiTect SYBR Green Assays in human, mouse, rat PPBP
    QuantiFast Probe-based Assays in human, mouse, rat PPBP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PPBP gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppbp5 pro-platelet basic protein   --   5 (44.78 cM) 90768518 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    37(a)
    1 → many
    4(50379773-50381069)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    36(a)
    1 → many
    6(60123888-60134622)


    ENSEMBL Gene Tree for PPBP (if available)
    TreeFam Gene Tree for PPBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPBP gene
    PF42  CXCL12  PF4V12  CXCL62  CXCL32  CXCL52  CXCL22  IL82  
    9 SIMAP similar genes for PPBP using alignment to 1 protein entry:     CXCL7_HUMAN:
    CXCL5    CXCL1    CXCL3    CXCL9    PF4    CXCL2
    IL8    PF4V1    CXCL6

    PPBP for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PPBP
    PGOHUM00000245591


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPBP (see all 108)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3775791,2
    C,F,A,H--74851660(+) GATAAC/TAATAA 1 -- ds500119Minor allele frequency- T:0.22NA NS EA WA CSA 816
    rs3520091,2
    C,F,H--74851693(+) TTTATA/GTGTGG 1 -- ds500119Minor allele frequency- G:0.26EA NA NS WA CSA 824
    rs557654751,2
    C--74851917(+) CAGATA/CATATC 1 -- ds50010--------
    rs1830281,2
    C,F,A,H--74851918(+) AGATCA/G/TTATCT 1 -- ds500123NS EA NA WA CSA 2340
    rs1478534561,2
    --74851962(+) AAACAC/TTTAGT 1 -- ds50010--------
    rs1865539011,2
    --74851977(+) CTGGCA/GTATTA 1 -- ds50010--------
    rs1906151891,2
    --74852219(+) TTTAGA/GGTTTA 1 -- ut310--------
    rs1829024601,2
    --74852220(+) TTAGGA/GTTTAA 1 -- ut310--------
    rs2022028261,2
    --74852287(+) TAAGG-/TTGAAG 1 -- ut310--------
    rs1886974551,2
    --74852372(+) CATCAA/TCTATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PPBP (74852156 - 74853914 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PPBP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525980CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPBP
    DNA2.0 Custom Variant and Variant Library Synthesis for PPBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 121010    OMIM disorders: --

    Selected diseases for PPBP (see all 93):    About MalaCards
    spinocerebellar ataxia, autosomal recessive, 10    hemoglobin e - beta-thalassemia    erythromelalgia    pulmonary edema
    essential thrombocythemia    sickle cell disease    polycythemia    steroid-resistant nephrotic syndrome
    peripheral vascular disease    thrombocytosis    rheumatic disease    hemorrhagic disease
    schistosomiasis    disseminated intravascular coagulation    heparin-induced thrombocytopenia    vascular disease
    nephrotic syndrome    allergic asthma    intermittent claudication    beta thalassemia

    6 diseases from the University of Copenhagen DISEASES database for PPBP:
    Heart disease     Hypertension     Thrombocytopenia     Cerebrovascular accident
    Peripheral vascular disease     Atherosclerosis

    PPBP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for PPBP gene (see all 79)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombocythemia essential 53.8 1 1836999 (1)
    thrombocytosis 50.7 4 1826402 (1), 12781799 (1), 1836999 (1), 17127481 (1)
    erythromelalgia 50.4 4 8883266 (3), 12781799 (1)
    essential hypertension 43.7 8 7489962 (1), 8522567 (1), 2144920 (1), 8266004 (1) (see all 7)
    thrombosis 41.6 3 11966476 (1), 20004006 (1), 9685818 (1)
    inflammation 39.3 18 10623425 (1), 11911809 (1), 9190946 (1), 17045893 (1) (see all 11)
    sclerosis systemic 39.2 1 8902649 (1)
    thrombophilia 35 1 8522567 (1)
    hemolysis 32.3 3 10886061 (1), 9304775 (1), 9335369 (1)
    thrombocytopenia 32.1 9 8695787 (2), 10468871 (1), 15884116 (1), 2142012 (1) (see all 7)

    Genetic Association Database (GAD): PPBP
    Human Genome Epidemiology (HuGE) Navigator: PPBP (10 documents)

    Export disorders for PPBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPBP gene, integrated from 10 sources (see all 548):
    (articles sorted by number of sources associating them with PPBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4. (PubMed id 1826003)1, 2, 3, 9 Majumdar S.... Poncz M. (J. Biol. Chem. 1991)
    2. Novel C-terminally truncated isoforms of the CXC chemokine beta- thromboglobulin and their impact on neutrophil functions. (PubMed id 9794434)1, 2, 9 Ehlert J.E.... Brandt E. (J. Immunol. 1998)
    3. Thrombin-activated human platelets release two NAP-2 variants that stimulate polymorphonuclear leukocytes. (PubMed id 8950790)1, 2, 9 Piccardoni P....Cerletti C. (Thromb. Haemost. 1996)
    4. Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases. (PubMed id 2406364)1, 2, 9 Walz A. and Baggiolini M. (J. Exp. Med. 1990)
    5. Localization of distal regulatory domains in the megakaryocyte- specific platelet basic protein/platelet factor 4 gene locus. (PubMed id 11468158)1, 2, 9 Zhang C.... Reilly M.P. (Blood 2001)
    6. The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution. (PubMed id 7706245)1, 2, 9 Malkowski M.G.... Edwards B.F.P. (J. Biol. Chem. 1995)
    7. Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines. (PubMed id 10877842)1, 2, 9 Krijgsveld J.... Dankert J. (J. Biol. Chem. 2000)
    8. Purification, crystallization and preliminary X-ray diffraction analysis of recombinant human neutrophil-activating peptide 2 (rhNAP- 2). (PubMed id 8034022)1, 2, 9 Kungl A.J.... Auer M. (FEBS Lett. 1994)
    9. Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide. (PubMed id 2007144)1, 2, 9 Clark-Lewis I....Aebersold R. (Biochemistry 1991)
    10. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5473 HGNC: 9240 AceView: PPBP Ensembl:ENSG00000163736 euGenes: HUgn5473
    ECgene: PPBP Kegg: 5473 H-InvDB: PPBP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPBP Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CXCL7

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PPBP gene:
    Search GeneIP for patents involving PPBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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