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Aliases for PPAT Gene

Aliases for PPAT Gene

  • Phosphoribosyl Pyrophosphate Amidotransferase 2 3
  • GPAT 3 4 6
  • Glutamine Phosphoribosylpyrophosphate Amidotransferase 3 4
  • EC 4 63
  • ATASE 3 4
  • Glutamine Phosphoribosylpyrophosphatate Amidotransferase 3
  • Glutamine PRPP Amidotransferase 3
  • Amidophosphoribosyltransferase 3
  • PRAT 3

External Ids for PPAT Gene

Previous GeneCards Identifiers for PPAT Gene

  • GC04M057063
  • GC04M057221
  • GC04M057109
  • GC04M057175
  • GC04M057100
  • GC04M056954
  • GC04M057259
  • GC04M053213

Summaries for PPAT Gene

Entrez Gene Summary for PPAT Gene

  • The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011]

GeneCards Summary for PPAT Gene

PPAT (Phosphoribosyl Pyrophosphate Amidotransferase) is a Protein Coding gene. Diseases associated with PPAT include phosphoribosylpyrophosphate synthetase superactivity and lesch-nyhan syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and amidophosphoribosyltransferase activity.

Gene Wiki entry for PPAT Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPAT Gene

Genomics for PPAT Gene

Regulatory Elements for PPAT Gene

Genomic Location for PPAT Gene

56,393,362 bp from pter
56,435,636 bp from pter
42,275 bases
Minus strand

Genomic View for PPAT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPAT Gene

Proteins for PPAT Gene

  • Protein details for PPAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for PPAT Gene

    517 amino acids
    Molecular mass:
    57399 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster per subunit.;
    Quaternary structure:
    • Homotetramer

neXtProt entry for PPAT Gene

Proteomics data for PPAT Gene at MOPED

Selected DME Specific Peptides for PPAT Gene

Post-translational modifications for PPAT Gene

  • Ubiquitination at Lys99, Lys349, and Lys372
  • Modification sites at PhosphoSitePlus

Other Protein References for PPAT Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for PPAT Gene

Suggested Antigen Peptide Sequences for PPAT Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 glutamine amidotransferase type-2 domain.
  • In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
  • Contains 1 glutamine amidotransferase type-2 domain.
  • In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
genes like me logo Genes that share domains with PPAT: view

No data available for Gene Families for PPAT Gene

Function for PPAT Gene

Molecular function for PPAT Gene

GENATLAS Biochemistry:
phosphoribosyl pyrophosphate amidotransferase,catalyzing the first step of the de novo purine biosynthesis
UniProtKB/Swiss-Prot CatalyticActivity:
5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O

Enzyme Numbers (IUBMB) for PPAT Gene

Gene Ontology (GO) - Molecular Function for PPAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004044 amidophosphoribosyltransferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0051539 4 iron, 4 sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with PPAT: view

Phenotypes for PPAT Gene

GenomeRNAi human phenotypes for PPAT:
genes like me logo Genes that share phenotypes with PPAT: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PPAT Gene

Localization for PPAT Gene

Subcellular locations from

Jensen Localization Image for PPAT Gene COMPARTMENTS Subcellular localization image for PPAT gene
Compartment Confidence
cytosol 4
cytoskeleton 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for PPAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PPAT: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPAT Gene

Pathways for PPAT Gene

genes like me logo Genes that share pathways with PPAT: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q06203-PUR1_HUMAN

  • Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2

Gene Ontology (GO) - Biological Process for PPAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0001822 kidney development IEA --
GO:0006144 purine nucleobase metabolic process TAS --
GO:0006164 purine nucleotide biosynthetic process TAS 8106516
GO:0006189 de novo IMP biosynthetic process IEA --
genes like me logo Genes that share ontologies with PPAT: view

Drugs for PPAT Gene

(3) Drugbank Compounds for PPAT Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (2S)-2-amino-4-carbamoylbutanoic acid
56-85-9 Target product of approved, investigational, nutraceutical
  • 5-Fluoracil
51-21-8 3385 Enzyme substrate approved
  • 1,7-Dihydro-6H-purine-6-thione
50-44-2 667490 Target approved

(7) HMDB Compounds for PPAT Gene

Compound Synonyms Cas Number PubMed IDs
  • 5-P-beta-D-Ribosyl-amine
L-Glutamic acid
  • (2S)-2-Aminopentanedioate
  • (2S)-2,5-diamino-5-oxopentanoate
  • Magnesium
Phosphoribosyl pyrophosphate
  • 5-Phospho-a-D-ribose-1-diphosphate

(32) Novoseek inferred chemical compound relationships for PPAT Gene

Compound -log(P) Hits PubMed IDs
hatpa 92.8 2
phosphoribosylamine 91.5 2
o6-benzylguanine 90.8 22
cb 10277 89.9 5
mitozolomide 87.2 6
genes like me logo Genes that share compounds with PPAT: view

Transcripts for PPAT Gene

Unigene Clusters for PPAT Gene

Phosphoribosyl pyrophosphate amidotransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPAT Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: -

Relevant External Links for PPAT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPAT Gene

mRNA expression in normal human tissues for PPAT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PPAT Gene

This gene is overexpressed in Lymph node (16.8) and Peripheral blood mononuclear cells (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPAT Gene

SOURCE GeneReport for Unigene cluster for PPAT Gene Hs.331420

mRNA Expression by UniProt/SwissProt for PPAT Gene

Tissue specificity: Ubiquitously expressed
genes like me logo Genes that share expressions with PPAT: view

Expression partners for PPAT Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PPAT Gene

Orthologs for PPAT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPAT Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPAT 35
  • 91.6 (n)
  • 93.6 (a)
  • 90 (a)
(Canis familiaris)
Mammalia PPAT 35
  • 92.46 (n)
  • 94.2 (a)
  • 94 (a)
(Mus musculus)
Mammalia Ppat 35
  • 85.94 (n)
  • 93.04 (a)
Ppat 16
Ppat 36
  • 93 (a)
(Pan troglodytes)
Mammalia PPAT 35
  • 99.42 (n)
  • 99.61 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ppat 35
  • 85.82 (n)
  • 93.42 (a)
(Monodelphis domestica)
Mammalia PPAT 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia PPAT 36
  • 86 (a)
(Gallus gallus)
Aves PPAT 35
  • 78.06 (n)
  • 84.39 (a)
  • 84 (a)
(Anolis carolinensis)
Reptilia PPAT 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76221 35
ppat 35
  • 72.98 (n)
  • 81.66 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68694 35
(Danio rerio)
Actinopterygii ppat 35
  • 68.96 (n)
  • 74.61 (a)
ppat 36
  • 75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6272 35
fruit fly
(Drosophila melanogaster)
Insecta Prat 37
  • 60 (a)
Prat2 37
  • 60 (a)
Prat2 35
  • 60.01 (n)
  • 65.43 (a)
Prat 36
  • 57 (a)
Prat2 36
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000179 35
  • 57.64 (n)
  • 65.99 (a)
(Caenorhabditis elegans)
Secernentea T04A8.5 37
  • 46 (a)
CELE_T04A8.5 35
  • 56.07 (n)
  • 50.21 (a)
T04A8.5 36
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADE4 36
  • 32 (a)
ADE4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ASE1 35
  • 51.23 (n)
  • 44.3 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1528 35
Species with no ortholog for PPAT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPAT Gene

Gene Tree for PPAT (if available)
Gene Tree for PPAT (if available)

Paralogs for PPAT Gene Pseudogenes for PPAT Gene

genes like me logo Genes that share paralogs with PPAT: view

No data available for Paralogs for PPAT Gene

Variants for PPAT Gene

Sequence variations from dbSNP and Humsavar for PPAT Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs573373295 -- 56,401,097(+) TCGAC(C/T)TTCAT intron-variant
rs572655525 -- 56,407,104(+) TTAAA(G/T)CATTT intron-variant
rs572233822 -- 56,406,052(+) TTGGT(A/G)TCCTC intron-variant
rs572025038 -- 56,398,214(+) AAATA(C/T)AAAAA intron-variant
rs571943345 -- 56,402,919(+) TTTAT(C/T)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPAT Gene

Variant ID Type Subtype PubMed ID
nsv829940 CNV Gain 17160897
nsv4347 CNV Loss 18451855

Relevant External Links for PPAT Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPAT Gene

Disorders for PPAT Gene

(1) University of Copenhagen DISEASES for PPAT Gene

(15) Novoseek inferred disease relationships for PPAT Gene

Disease -log(P) Hits PubMed IDs
metastatic melanoma 31.8 1
melanoma 26.5 6
glioma 24.6 4
malignant glioma 18.7 1
hodgkin disease 3.08 1
genes like me logo Genes that share disorders with PPAT: view

No data available for OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for PPAT Gene

Publications for PPAT Gene

  1. Two genes for de novo purine nucleotide synthesis on human chromosome 4 are closely linked and divergently transcribed. (PMID: 8106516) Brayton K.A. … Zalkin H. (J. Biol. Chem. 1994) 3 4 23
  2. Molecular cloning of human amidophosphoribosyltransferase. (PMID: 8380692) Iwahana H. … Itakura M. (Biochem. Biophys. Res. Commun. 1993) 3 4 23
  3. Interdomain signaling in glutamine phosphoribosylpyrophosphate amidotransferase. (PMID: 10593947) Bera A.K. … Zalkin H. (J. Biol. Chem. 1999) 3 23
  4. Role of NRF-1 in bidirectional transcription of the human GPAT-AIRC purine biosynthesis locus. (PMID: 9108165) Chen S. … Zalkin H. (Nucleic Acids Res. 1997) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PPAT Gene

Sources for PPAT Gene

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