Aliases for PPAT Gene
External Ids for PPAT Gene
Previous GeneCards Identifiers for PPAT Gene
The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011]
GeneCards Summary for PPAT Gene
PPAT (Phosphoribosyl Pyrophosphate Amidotransferase) is a Protein Coding gene. Diseases associated with PPAT include Phosphoribosylpyrophosphate Synthetase Superactivity and Purine-Pyrimidine Metabolic Disorder. Among its related pathways are Purine metabolism (REACTOME) and One carbon pool by folate. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and amidophosphoribosyltransferase activity.