PPAT Gene
protein-coding GIFtS: 63
GCID: GC04M057259
|
|
phosphoribosyl pyrophosphate amidotransferase
| |
Aliases
for PPAT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Phosphoribosyl Pyrophosphate Amidotransferase1 2 | | ATASE2 | | GPAT1 2 3 5 | | Amidophosphoribosyltransferase1 | | PRAT1 2 | | Glutamine Phosphoribosylpyrophosphatate Amidotransferase2 | | Glutamine Phosphoribosylpyrophosphate Amidotransferase2 3 | | Glutamine PRPP Amidotransferase2 | | EC 2.4.2.143 8 | | ATase3 |
Export aliases for PPAT gene to outside databasesPrevious GC identifers: GC04M057063 GC04M057221 GC04M057109 GC04M057175 GC04M057100 GC04M056954 GC04M053213 |
Summaries
for PPAT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PPAT:
The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is aregulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This geneand PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in closeproximity on chromosome 4, and divergently transcribed from an intergenic region. (provided by RefSeq, Mar 2011)
Gene Wiki entry for PPAT (Amidophosphoribosyltransferase)
|
Genomic Views
for PPAT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_022853.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PPAT gene promoter:
TBP p53 AML1a ATF-2 MyoD AREB6 CP2 STAT3 IRF-7A RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for PPAT
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPAT |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q12 Ensembl cytogenetic band: 4q12 HGNC cytogenetic band: 4q12PPAT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M057259: view genomic region
(about GC identifiers)
Start:
|
57,259,528 bp from pter |
End:
|
57,301,845 bp from pter |
Size:
|
42,318 bases |
Orientation:
|
minus strand |
|
Proteins
for PPAT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PUR1_HUMAN, Q06203 (See
protein sequence)Recommended Name: Amidophosphoribosyltransferase precursor Size: 517 amino acids; 57399 Da
Cofactor: Binds 1 magnesium ion per subunit (By similarity)
Cofactor: Binds 1 4Fe-4S cluster per subunit (By similarity)
Subunit: HomotetramerExplore the universe of human proteins at neXtProt for PPAT: NX_Q06203
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q06203
4/9 DME Specific Peptides for PPAT (Q06203) (see all 9)
PPAT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002694.3
ENSEMBL proteins: ENSP00000264220 ENSP00000423781 ENSP00000425119 Reactome Protein details: Q06203
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
PPAT for ontologies About GeneDecksing
PPAT Antibody Products:
Assay Products for PPAT: |
Protein
Domains /
Families
for PPAT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PPAT for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q06203ProtoNet protein and cluster: Q06203 1 Blocks protein family: IPB002375 Purine/pyrimidine phosphoribosyl transferase
UniProtKB/Swiss-Prot: PUR1_HUMAN, Q06203Similarity: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase familySimilarity: Contains 1 glutamine amidotransferase type-2 domain |
Function
for PPAT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PUR1_HUMAN, Q06203Catalytic activity: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose1-diphosphate + H(2)O Genatlas biochemistry entry for PPAT:phosphoribosyl pyrophosphate amidotransferase,catalyzing the first step of the de novo purine biosynthesis
Enzyme Number (IUBMB): EC 2.4.2.141 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPAT (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPAT (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PPAT (NM_002703) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPAT | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPAT |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPAT |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004044 | amidophosphoribosyltransferase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- | | GO:0051539 | 4 iron, 4 sulfur cluster binding |
IEA | -- |
PPAT for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PPAT:
Animal Models:
1 MGI phenotypic allele  for Ppat (no phenotypes)
PPAT for phenotypes About GeneDecksing
|
Pathways & Interactions
for PPAT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | purine nucleotides de novo biosynthesis II | | | 2 | Antimetabolite Pathway - Folate Cycle, Pharmacodynamics | | | 3 | Purine metabolism | | | 4 | Fluoropyrimidine Activity | | | 5 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PPAT
3  BioSystems Pathways for PPAT
4 
Reactome Pathways for PPAT
4  PharmGKB Pathways for PPAT
3 
Kegg Pathways (Kegg details for PPAT):
UniProtKB/Swiss-Prot: PUR1_HUMAN, Q06203Pathway: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from5-phospho-alpha-D-ribose 1-diphosphate: step 1/2
PPAT for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPAT
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/101 Interacting proteins for PPAT (Q062033 ENSP000002642204) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
About this table
Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000082 | G1/S transition of mitotic cell cycle |
IEA | -- | | GO:0001822 | kidney development |
IEA | -- | | GO:0006144 | purine nucleobase metabolic process |
TAS | -- | | GO:0006164 | purine nucleotide biosynthetic process |
TAS | 8106516 | | GO:0006189 | 'de novo' IMP biosynthetic process |
IEA | -- |
PPAT for ontologies About GeneDecksing
|
Drugs & Compounds
for PPAT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PPAT for compounds About GeneDecksing
 Browse Tocris compounds for PPAT
9 HMDB Compounds for PPAT About this table
1 DrugBank Compound for PPAT About this table
10/32 Novoseek chemical compound relationships for PPAT gene (see all 32) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hatpa |
92.8 |
2 |
10557052 (1), 9725988 (1) |
| phosphoribosylamine |
91.5 |
3 |
7532005 (2) |
| o6-benzylguanine |
90.8 |
42 |
8129725 (3), 8512814 (3), 9815932 (2), 8908500 (2) (see all 16) |
| cb 10277 |
89.9 |
5 |
1464162 (3), 8033139 (2) |
| mitozolomide |
87.2 |
8 |
1312399 (3), 1419626 (2), 8512814 (1) |
| prpp |
85.5 |
12 |
11290738 (2), 8314584 (1), 1311306 (1), 15566465 (1) (see all 8) |
| fotemustine |
85 |
14 |
1824685 (3), 9516937 (2), 8512821 (1), 8431354 (1) (see all 7) |
| o(6)-methyldeoxyguanosine |
85 |
14 |
11448648 (2), 8180013 (2), 8033139 (2) |
| chloroethyl nitrosoureas |
81.3 |
8 |
8761416 (2), 9815932 (2) |
| temozolomide |
74.6 |
21 |
10647496 (4), 8512814 (3), 8123472 (3), 7828668 (3) (see all 8) |
Search CenterWatch for drugs/clinical trials and news about PPAT / PUR1
|
Transcripts
for PPAT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PPAT gene: NM_002703.4 Unigene Cluster for PPAT: Phosphoribosyl pyrophosphate amidotransferase Hs.331420 [show with all ESTs]Unigene Representative Sequence: AB2092465 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264220(uc003hbr.3) ENST00000425339 ENST00000507648 ENST00000510643
ENST00000507724
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPAT (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPAT (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PPAT (NM_002703) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PPAT | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPAT |
Additional cDNA sequence: AB209246.1 AK222759.1 AK290942.1 AK312297.1 BC004200.2 D13757.1 U00238.1 11 DOTS entries: DT.95340067 DT.95268423 DT.453889 DT.40281814 DT.121644170 DT.121267351 DT.121267393 DT.100818463 DT.100885672 DT.121267343 DT.97815824 24/196 AceView cDNA sequences (see all 196): CA421287 AW008472 N28807 BQ000651 CR599321 D13757 AL527871 BC004200 CR596411 AA826427 CR592110 CD657552 BQ229606 BX282402 AI146356 CB044540 AU103390 BU165960 F07938 AU142764 BU181806 BF476510 AA829629 NM_002703
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PPAT (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | | | - | | | | | | - | | - | | - | | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PPAT
|
Expression
for PPAT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PPAT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTTTTACT
About this image
See PPAT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPAT
SOURCE GeneReport for Unigene cluster: Hs.331420
UniProtKB/Swiss-Prot: PUR1_HUMAN, Q06203Tissue specificity: Ubiquitously expressed
SABiosciences Expression via Pathway-Focused PCR Array including PPAT:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPAT
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPAT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPAT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPAT | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPAT |
Orthologs
for PPAT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for PPAT gene from 9/33 species (see all 33) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PPAT1 |
phosphoribosyl pyrophosphate amidotransferase |
78.17(n)
83.73(a) |
|
422743 NM_001004401.1 NP_001004401.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PPAT6 |
-- |
82(a) |
1 ↔ 1 |
5(105344584-105357018) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC686942 |
hypothetical protein MGC68694 |
76.06(n) |
|
BC060430.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ppat1 |
phosphoribosyl pyrophosphate amidotransferase |
69.09(n)
74.61(a) |
|
572027 NM_001082877.2 NP_001076346.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Prat3
Prat21 |
'de novo' IMP biosynthesis
amidophosphoribosyltransferase3
Phosphoribosylamidotransferase 21 |
60(a)
(best of 2)3
60.01(n)1
65.43(a)1 |
|
84E53
387531 NM_079225.21 NP_523949.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
T04A8.53
CELE_T04A8.51 |
Amidophosphoribosyltransferase3
Protein T04A8.51 |
46(a)3
56.4(n)1
50.53(a)1 |
|
III(4761135-4763868)3
1756131 NM_065557.51 NP_497958.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ASE11 |
amidophosphoribosyltransferase |
51.3(n)
44.97(a) |
|
816156 NM_127208.1 NP_179247.1 |
rice
(Oryza sativa) |
Liliopsida |
---- |
amidophosphoribosyltransferase, chloroplast precur...amidophosphoribosyltransferase, chloroplast precur... |
34(a)34(a) |
1 ↔ many1 ↔ many |
5(21078817-21080975) 1(37865070-37867017) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
purF6 |
amidophosphoribosyltransferase |
33(a) |
1 ↔ 1 |
Chromosome(2426743-2428260) |
ENSEMBL Gene Tree for PPAT (if available)
TreeFam Gene Tree for PPAT (if available) |
Paralogs
for PPAT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PPAT gene
PPAT for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for PPAT
PGOHUM00000237672 PGOHUM00000241410
|
Genomic Variants
for PPAT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Human Gene Mutation Database (HGMD): PPAT
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPAT |
|
Disorders
/ Diseases
for PPAT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PPAT for disorders About GeneDecksing
OMIM gene information: 172450
OMIM disorders: --
20/24  diseases for PPAT (see all 24): About MalaCardsphosphoribosylpyrophosphate synthetase superactivity lesch-nyhan syndrome malignant glioma strongyloidiasis
insulin resistance hepatocellular carcinoma schistosomiasis rheumatoid arthritis
ovarian cancer melanoma hepatitis b hepatoblastoma
breast cancer hematopoiesis medulloblastoma arthritis
lung cancer hepatitis pneumonia carcinoma
10/15 Novoseek disease relationships for PPAT gene (see all 15) About this table
Export disorders for PPAT gene to outside databases
|
Publications
for PPAT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PPAT gene, integrated from 9 sources (see all 122):
(articles sorted by number of sources associating them with PPAT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of human amidophosphoribosyltransferase. (PubMed id 8380692)1, 2, 9 Iwahana H.... Itakura M. (1993)
- Two genes for de novo purine nucleotide synthesis on human chromosome 4 are closely linked and divergently transcribed. (PubMed id 8106516)1, 2, 9 Brayton K.A.... Zalkin H. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Role of NRF-1 in bidirectional transcription of the human GPAT-AIRC purine biosynthesis locus. (PubMed id 9108165)1, 9 Chen S....Zalkin H. (1997)
- Interdomain signaling in glutamine phosphoribosylpyrophosphate amidotransferase. (PubMed id 10593947)1, 9 Bera A.K....Zalkin H. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for PPAT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PPAT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PPAT gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PPAT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PPAT | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PPAT gene:
Search GeneIP for patents involving PPAT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PPAT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for PPAT | | OriGene shRNA RFP for PPAT | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPAT | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PPAT | | | OriGene Protein Over-expression Lysate for PPAT | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for PPAT | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPAT | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPAT | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PPAT | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PPAT | | OriGene Custom Protein Services for PPAT | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPAT | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPAT | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPAT | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPAT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPAT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPAT |
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| | | | Search Tocris compounds for PPAT |
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 | | | PPAT Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPAT |
|  |  |  | | | | ThermoFisher Antibodies for PPAT |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPAT |
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