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Aliases for PPARGC1B Gene

Aliases for PPARGC1B Gene

  • PPARG Coactivator 1 Beta 2 3 5
  • Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Beta 2 3
  • PGC-1-Related Estrogen Receptor Alpha Coactivator 3 4
  • PPAR-Gamma Coactivator 1-Beta 3 4
  • PPARgamma Coactivator 1 Beta 2 3
  • PPARGC-1-Beta 3 4
  • PGC1B 3 4
  • PERC 3 4
  • Peroxisome Proliferative Activated Receptor, Gamma, Coactivator 1, Beta 2
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Beta 3
  • PGC-1(Beta) 3
  • PGC-1-Beta 4
  • PPARGC1 4
  • ERRL1 3
  • PGC1 4

External Ids for PPARGC1B Gene

Previous GeneCards Identifiers for PPARGC1B Gene

  • GC05P149138
  • GC05P149090
  • GC05P149109
  • GC05P144256

Summaries for PPARGC1B Gene

Entrez Gene Summary for PPARGC1B Gene

  • The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for PPARGC1B Gene

PPARGC1B (PPARG Coactivator 1 Beta) is a Protein Coding gene. Diseases associated with PPARGC1B include Obesity and Obesity, Ppargc1b-Related. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PPARGC1A.

UniProtKB/Swiss-Prot for PPARGC1B Gene

  • Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.

Gene Wiki entry for PPARGC1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPARGC1B Gene

Genomics for PPARGC1B Gene

Regulatory Elements for PPARGC1B Gene

Enhancers for PPARGC1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F149751 1.2 Ensembl ENCODE 17.4 +21.6 21570 1.2 ESRRA TAL1 RAD21 ZNF316 CTBP1 GATA3 RCOR1 MAFK ZNF687 HLF PPARGC1B ENSG00000221043 RNU6-588P GC05P149733 GC05P149853
GH05F149756 0.6 ENCODE 17.2 +27.2 27232 1.5 ZNF687 PPARGC1B MIR378A ENSG00000221043 RNU6-588P GC05P149733 GC05P149853
GH05F149729 1 FANTOM5 ENCODE 13.9 +1.6 1582 4.0 HDGF CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ENSG00000248696 PPARGC1B LOC644762 IL17B CAMK2A AFAP1L1 ARHGEF37 CDX1 SLC26A2 GC05P149734
GH05F149821 0.4 ENCODE 12.1 +91.0 91041 0.2 ZNF664 NFE2 NFE2L2 MIR378A PPARGC1B RNU6-588P HMGXB3 TIGD6 GC05P149853 GC05P149733
GH05F149775 1.3 FANTOM5 Ensembl ENCODE 7.4 +49.4 49447 7.7 HDGF PKNOX1 MLX WRNIP1 ZNF2 ZNF48 YY1 CBX5 FOS JUNB HMGXB3 PCYOX1L ENSG00000221043 RNU6-588P TIGD6 PPARGC1B GRPEL2-AS1 AFAP1L1 RPS14 GC05P149733
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PPARGC1B on UCSC Golden Path with GeneCards custom track

Promoters for PPARGC1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001293642 1249 3400 HDGF WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for PPARGC1B Gene

Chromosome:
5
Start:
149,730,252 bp from pter
End:
149,857,874 bp from pter
Size:
127,623 bases
Orientation:
Plus strand

Genomic View for PPARGC1B Gene

Genes around PPARGC1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPARGC1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPARGC1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPARGC1B Gene

Proteins for PPARGC1B Gene

  • Protein details for PPARGC1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YN6-PRGC2_HUMAN
    Recommended name:
    Peroxisome proliferator-activated receptor gamma coactivator 1-beta
    Protein Accession:
    Q86YN6
    Secondary Accessions:
    • A2RUM8
    • A2RUN0
    • B3KVW0
    • Q86YN3
    • Q86YN4
    • Q86YN5
    • Q8N1N9
    • Q8TDE4
    • Q8TDE5

    Protein attributes for PPARGC1B Gene

    Size:
    1023 amino acids
    Molecular mass:
    113222 Da
    Quaternary structure:
    • Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16 (By similarity). Interacts with estrogen receptor alpha/ESR1.

    Three dimensional structures from OCA and Proteopedia for PPARGC1B Gene

    Alternative splice isoforms for PPARGC1B Gene

neXtProt entry for PPARGC1B Gene

Post-translational modifications for PPARGC1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for PPARGC1B Gene

Domains & Families for PPARGC1B Gene

Gene Families for PPARGC1B Gene

Protein Domains for PPARGC1B Gene

Graphical View of Domain Structure for InterPro Entry

Q86YN6

UniProtKB/Swiss-Prot:

PRGC2_HUMAN :
  • Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.
Domain:
  • Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with PPARGC1B: view

Function for PPARGC1B Gene

Molecular function for PPARGC1B Gene

UniProtKB/Swiss-Prot Function:
Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
UniProtKB/Swiss-Prot Induction:
Repressed by saturated fatty acids such as palmitate and stearate in skeletal muscle cells. Induced by insulin and reduced by aging in skeletal muscle biopsies. Down-regulated in type 2 diabetes mellitus subjects as well as in pre-diabetics.

Gene Ontology (GO) - Molecular Function for PPARGC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001104 RNA polymerase II transcription cofactor activity IDA 11854298
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding NAS 11854298
GO:0008134 transcription factor binding IBA --
genes like me logo Genes that share ontologies with PPARGC1B: view
genes like me logo Genes that share phenotypes with PPARGC1B: view

Animal Models for PPARGC1B Gene

MGI Knock Outs for PPARGC1B:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPARGC1B Gene

Localization for PPARGC1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPARGC1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPARGC1B Gene COMPARTMENTS Subcellular localization image for PPARGC1B gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 3
extracellular 1

Gene Ontology (GO) - Cellular Components for PPARGC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 11854298
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion IEA --
GO:0016592 mediator complex IDA 11854298
genes like me logo Genes that share ontologies with PPARGC1B: view

Pathways & Interactions for PPARGC1B Gene

genes like me logo Genes that share pathways with PPARGC1B: view

Gene Ontology (GO) - Biological Process for PPARGC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 23836911
GO:0006390 transcription from mitochondrial promoter IEA --
GO:0007005 mitochondrion organization TAS --
genes like me logo Genes that share ontologies with PPARGC1B: view

No data available for SIGNOR curated interactions for PPARGC1B Gene

Drugs & Compounds for PPARGC1B Gene

(2) Drugs for PPARGC1B Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2- methylphenoxy)acetic acid Pharma 0

(1) Additional Compounds for PPARGC1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PPARGC1B: view

Transcripts for PPARGC1B Gene

Unigene Clusters for PPARGC1B Gene

Peroxisome proliferator-activated receptor gamma, coactivator 1 beta:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPARGC1B Gene

No ASD Table

Relevant External Links for PPARGC1B Gene

GeneLoc Exon Structure for
PPARGC1B
ECgene alternative splicing isoforms for
PPARGC1B

Expression for PPARGC1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPARGC1B Gene

NURSA nuclear receptor signaling pathways regulating expression of PPARGC1B Gene:

PPARGC1B

SOURCE GeneReport for Unigene cluster for PPARGC1B Gene:

Hs.483816

mRNA Expression by UniProt/SwissProt for PPARGC1B Gene:

Q86YN6-PRGC2_HUMAN
Tissue specificity: Ubiquitous with higher expression in heart, brain and skeletal muscle.
genes like me logo Genes that share expression patterns with PPARGC1B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PPARGC1B Gene

Orthologs for PPARGC1B Gene

This gene was present in the common ancestor of animals.

Orthologs for PPARGC1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPARGC1B 34 35
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia PPARGC1B 34 35
  • 88.33 (n)
cow
(Bos Taurus)
Mammalia PPARGC1B 34 35
  • 86.24 (n)
mouse
(Mus musculus)
Mammalia Ppargc1b 34 16 35
  • 82.74 (n)
rat
(Rattus norvegicus)
Mammalia Ppargc1b 34
  • 81.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPARGC1B 35
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPARGC1B 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPARGC1B 34 35
  • 64.07 (n)
lizard
(Anolis carolinensis)
Reptilia PPARGC1B 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppargc1b 34
  • 55.31 (n)
Str.17645 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.20150 34
zebrafish
(Danio rerio)
Actinopterygii ppargc1b 34 35
  • 52.88 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Spargel 35
  • 11 (a)
OneToMany
Species where no ortholog for PPARGC1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPARGC1B Gene

ENSEMBL:
Gene Tree for PPARGC1B (if available)
TreeFam:
Gene Tree for PPARGC1B (if available)

Paralogs for PPARGC1B Gene

Paralogs for PPARGC1B Gene

genes like me logo Genes that share paralogs with PPARGC1B: view

Variants for PPARGC1B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PPARGC1B Gene

PRGC2_HUMAN-Q86YN6
Variation of PPARGC1B may contribute to the pathogenesis of obesity, with a widespread Ala-203 allele being a risk factor for the development of this common disorders.

Sequence variations from dbSNP and Humsavar for PPARGC1B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs7732671 other 149,832,680(+) AGAAG(C/G)CTCCC reference, missense, utr-variant-5-prime
rs10036538 -- 149,776,025(+) GACTG(C/G)CCAAC intron-variant
rs10037549 -- 149,757,557(+) CCCTG(A/C)CAGCC intron-variant
rs10038434 -- 149,755,600(+) ttgtt(A/G)ttatt intron-variant
rs10042025 -- 149,768,600(+) cacca(C/T)gtctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPARGC1B Gene

Variant ID Type Subtype PubMed ID
dgv10112n54 CNV gain 21841781
dgv727n27 CNV gain 19166990
esv1706104 CNV deletion 17803354
esv24664 CNV gain+loss 19812545
esv2730909 CNV deletion 23290073
esv2730910 CNV deletion 23290073
esv32926 CNV gain 17666407
esv3566805 CNV deletion 23714750
esv3890751 CNV gain 25118596
nsv1019813 CNV gain 25217958
nsv1023343 CNV gain 25217958
nsv1027896 CNV gain 25217958
nsv1073502 CNV deletion 25765185
nsv1073923 CNV deletion 25765185
nsv1143316 CNV deletion 24896259
nsv462482 CNV loss 19166990
nsv462484 CNV loss 19166990
nsv5060 CNV deletion 18451855
nsv5061 CNV insertion 18451855
nsv599949 CNV loss 21841781
nsv599950 CNV loss 21841781
nsv950425 CNV deletion 24416366

Variation tolerance for PPARGC1B Gene

Residual Variation Intolerance Score: 86.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.79; 86.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPARGC1B Gene

Human Gene Mutation Database (HGMD)
PPARGC1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPARGC1B

Disorders for PPARGC1B Gene

MalaCards: The human disease database

(6) MalaCards diseases for PPARGC1B Gene - From: OMIM, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
obesity, ppargc1b-related
  • obesity, variation in
kidney lipoma
  • lipoma of kidney
vulvitis
vulvar disease
  • vulvar disorders
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPARGC1B

Genetic Association Database (GAD)
PPARGC1B
Human Genome Epidemiology (HuGE) Navigator
PPARGC1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPARGC1B
genes like me logo Genes that share disorders with PPARGC1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPARGC1B Gene

Publications for PPARGC1B Gene

  1. Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. (PMID: 15863669) Andersen G. … Pedersen O. (J. Med. Genet. 2005) 3 4 22 46 64
  2. The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. (PMID: 11854298) Kressler D. … Kralli A. (J. Biol. Chem. 2002) 2 3 4 22 64
  3. Impact of the peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1beta expression and fibre type composition in human skeletal muscle. (PMID: 17579828) Ling C. … Poulsen P. (Diabetologia 2007) 3 22 46 64
  4. Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC- 1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells. (PMID: 23836911) Cho Y. … Kralli A. (J. Biol. Chem. 2013) 3 4 64
  5. Single-nucleotide polymorphisms within the antioxidant defence system and associations with aggressive prostate cancer. (PMID: 20477822) Abe M. … Chan J.M. (BJU Int. 2011) 3 46 64

Products for PPARGC1B Gene

Sources for PPARGC1B Gene

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