Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PPARGC1B Gene

protein-coding   GIFtS: 53
GCID: GC05P149109

Peroxisome Proliferator-Activated Receptor Gamma, Coactivator...

(Previous names: peroxisome proliferative activated receptor, gamma, coactivator...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1
Beta1 2
     ERRL12
PERC2 3 5     PGC-1(beta)2
PGC1B2 3 5     Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Beta2
PPARGC-1-beta2 3     PGC-1-beta3
PGC-1-Related Estrogen Receptor Alpha Coactivator2 3     PGC13
PPAR-Gamma Coactivator 1-Beta2 3     PPARGC13
Peroxisome Proliferative Activated Receptor, Gamma, Coactivator 1, Beta1     

External Ids:    HGNC: 300221   Entrez Gene: 1335222   Ensembl: ENSG000001558467   OMIM: 6088865   UniProtKB: Q86YN63   

Export aliases for PPARGC1B gene to outside databases

Previous GC identifers: GC05P149138 GC05P149090 GC05P144256


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PPARGC1B Gene:
The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors,
including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein
may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure.
This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in
this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Mar 2010)

GeneCards Summary for PPARGC1B Gene:
PPARGC1B (peroxisome proliferator-activated receptor gamma, coactivator 1 beta) is a protein-coding gene. Diseases associated with PPARGC1B include obesity, variation in, and vulvitis. GO annotations related to this gene include RNA binding and ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is PPRC1.

UniProtKB/Swiss-Prot: PRGC2_HUMAN, Q86YN6
Function: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates
transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid
receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated
mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when
overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of
energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner

Gene Wiki entry for PPARGC1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPARGC1B gene promoter:
         Pax-3   STAT1   p300   AP-4   Nkx2-5   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPARGC1B promoter sequence
   Search Chromatin IP Primers for PPARGC1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPARGC1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q33.1

PPARGC1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPARGC1B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P149109:  view genomic region     (about GC identifiers)

Start:
149,109,815 bp from pter      End:
149,234,585 bp from pter
Size:
124,771 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PRGC2_HUMAN, Q86YN6 (See protein sequence)
Recommended Name: Peroxisome proliferator-activated receptor gamma coactivator 1-beta  
Size: 1023 amino acids; 113222 Da
Subunit: Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor
1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with
estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16 (By similarity). Interacts with
estrogen receptor alpha/ESR1
1 PDB 3D structure from and Proteopedia for PPARGC1B:
3SP6 (3D)    
Secondary accessions: A2RUM8 A2RUN0 B3KVW0 Q86YN3 Q86YN4 Q86YN5 Q8N1N9 Q8TDE4 Q8TDE5
Alternative splicing: 6 isoforms:  Q86YN6-1   Q86YN6-2   Q86YN6-3   Q86YN6-4   Q86YN6-5   Q86YN6-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPARGC1B: NX_Q86YN6

Explore proteomics data for PPARGC1B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPARGC1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001166169.1  NP_001166170.1  NP_573570.3  

    ENSEMBL proteins: 
     ENSP00000353638   ENSP00000377855   ENSP00000312649   ENSP00000384403   ENSP00000409364  
    Reactome Protein details: Q86YN6

    PPARGC1B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PPARGC1B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PPARGC1B
    GenScript Custom Purified and Recombinant Proteins Services for PPARGC1B
    Novus Biologicals PPARGC1B Protein
    Novus Biologicals PPARGC1B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    PPARGC1B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PPARGC1B
    OriGene Custom Antibody Services for PPARGC1B
    Novus Biologicals PPARGC1B Antibodies
    Abcam antibodies for PPARGC1B
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PPARGC1B
    LSBio Antibodies in human, mouse, rat for PPARGC1B

    PPARGC1B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PPARGC1B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPARGC1B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q86YN6

    ProtoNet protein and cluster: Q86YN6

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: PRGC2_HUMAN, Q86YN6
    Domain: Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear
    receptors (By similarity)
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    PPARGC1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRGC2_HUMAN, Q86YN6
    Function: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates
    transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid
    receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated
    mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when
    overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of
    energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner
    Induction: Repressed by saturated fatty acids such as palmitate and stearate in skeletal muscle cells. Induced by
    insulin and reduced by aging in skeletal muscle biopsies. Down-regulated in type 2 diabetes mellitus subjects as
    well as in pre-diabetics

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0001104RNA polymerase II transcription cofactor activity IDA11854298
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding NAS11854298
    GO:0005515protein binding ----
         
    PPARGC1B for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Ppargc1b):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     muscle  no phenotypic analysis  respiratory system  skeleton 

    PPARGC1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PPARGC1B: Ppargc1btm1.1Rev Ppargc1btm1.1Dpk Ppargc1btm1.1Avp

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPARGC1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPARGC1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPARGC1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPARGC1B

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPARGC1B:
    hsa-mir-3687 (MIRT052880), hsa-mir-23b-3p (MIRT046313), hsa-mir-484 (MIRT042182), hsa-mir-193b-3p (MIRT041586), hsa-mir-423-5p (MIRT038154), hsa-mir-186-5p (MIRT044931)

    Block miRNA regulation of human, mouse, rat PPARGC1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPARGC1B (see all 245):
    hsa-miR-194* hsa-miR-576-3p hsa-miR-579 hsa-miR-26a-2* hsa-miR-520f hsa-miR-106a hsa-miR-4275 hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidPPARGC1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPARGC1B
    Predesigned siRNA for gene silencing in human, mouse, rat PPARGC1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPARGC1B

    Clone
    Products:
         
    OriGene clones in human, mouse for PPARGC1B (see all 15)
    OriGene ORF clones in mouse, rat for PPARGC1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PPARGC1B (NM_133263)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPARGC1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPARGC1B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PPARGC1B
    Browse ESI BIO Cell Lines and PureStem Progenitors for PPARGC1B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPARGC1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PRGC2_HUMAN, Q86YN6: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11854298
    GO:0005654nucleoplasm TAS--
    GO:0005739mitochondrion IEA--
    GO:0016592mediator complex IDA11854298

    PPARGC1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PPARGC1B About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    SREBP signalling0.31
    4SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways
    5Mitochondrial Gene Expression
    Mitochondrial Gene Expression

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for PPARGC1B
        Mitochondrial Gene Expression
    AMPK signaling
    SIDS Susceptibility Pathways
    SREBP signalling
    Energy Metabolism

    2 Reactome Pathways for PPARGC1B
        PPARA activates gene expression
    Transcriptional activation of mitochondrial biogenesis



    PPARGC1B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPARGC1B: 
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Diabetes in human mouse rat
              PPAR Targets in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPARGC1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPARGC1B (Q86YN63 ENSP000003126494) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZBTB9Q96C003, ENSP000003785034I2D: score=1 STRING: ENSP00000378503
    ENSG00000236515Q96C003I2D: score=1 
    LRPPRCP427043, ENSP000002606654I2D: score=1 STRING: ENSP00000260665
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    HNF4AP412353, ENSP000003129874I2D: score=1 STRING: ENSP00000312987
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0006355regulation of transcription, DNA-templated IDA--
    GO:0006366transcription from RNA polymerase II promoter IDA11854298
    GO:0006390transcription from mitochondrial promoter IEA--
    GO:0007015actin filament organization IEA--

    PPARGC1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PPARGC1B (PRGC2)

    2 Novoseek inferred chemical compound relationships for PPARGC1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fructose 47.3 1 19254570 (1)
    fatty acid 33.6 1 11733490 (1)



    PPARGC1B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PPARGC1B gene (3 alternative transcripts): 
    NM_001172698.1  NM_001172699.1  NM_133263.3  

    Unigene Cluster for PPARGC1B:

    Peroxisome proliferator-activated receptor gamma, coactivator 1 beta
    Hs.483816  [show with all ESTs]
    Unigene Representative Sequence: NM_133263
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360453 ENST00000394320(uc003lrb.2 uc003lre.1) ENST00000461780
    ENST00000309241(uc003lrc.3 uc003lrd.3 uc021yfr.1 uc003lrf.3)
    ENST00000403750 ENST00000434684 ENST00000492495
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PPARGC1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPARGC1B (see all 245):
    hsa-miR-194* hsa-miR-576-3p hsa-miR-579 hsa-miR-26a-2* hsa-miR-520f hsa-miR-106a hsa-miR-4275 hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidPPARGC1B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PPARGC1B
    Predesigned siRNA for gene silencing in human, mouse, rat PPARGC1B
    Clone
    Products:
         
    OriGene clones in human, mouse for PPARGC1B (see all 15)
    OriGene ORF clones in mouse, rat for PPARGC1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PPARGC1B (NM_133263)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPARGC1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPARGC1B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PPARGC1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPARGC1B
      QuantiTect SYBR Green Assays in human, mouse, rat PPARGC1B
      QuantiFast Probe-based Assays in human, mouse, rat PPARGC1B

    Additional mRNA sequence: 

    AF468496.1 AF468497.1 AK024346.1 AK095391.1 AK123614.1 AK123715.1 AY188947.1 AY188948.1 
    AY188949.1 AY188950.1 BC026956.1 BC132971.1 BC132973.1 BC144251.1 BX648997.1 

    13 DOTS entries:

    DT.97835483  DT.91925038  DT.100752442  DT.40260058  DT.100752441  DT.101963476  DT.97770463  DT.101957170 
    DT.40190389  DT.95247975  DT.40265079  DT.40265081  DT.436919 

    Selected AceView cDNA sequences (see all 34):

    AF468496 BM720077 BM725763 AW236547 AF468497 AY188947 NM_133263 AK123715 
    AY188948 AK095391 BM725569 BX283828 AK123614 AF056986 AW811710 BU955896 
    BU739891 CB992747 CB962005 AY188949 W70044 BG829583 BU539125 AY188950 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PPARGC1B expression in normal human tissues (normalized intensities)      PPARGC1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTGTAAAT
    PPARGC1B Expression
    About this image


    PPARGC1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 4 entries
             Thoracic Perivascular Adipose
             Brown adipocyte-like cells
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
    PPARGC1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPARGC1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.483816

    UniProtKB/Swiss-Prot: PRGC2_HUMAN, Q86YN6
    Tissue specificity: Ubiquitous with higher expression in heart, brain and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPARGC1B: 
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Diabetes in human mouse rat
              PPAR Targets in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PPARGC1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPARGC1B
    QuantiTect SYBR Green Assays in human, mouse, rat PPARGC1B
    QuantiFast Probe-based Assays in human, mouse, rat PPARGC1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPARGC1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for PPARGC1B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppargc1b1 , 5 peroxisome proliferative activated receptor, gamma, more1, 5 82.74(n)1
    79.5(a)1
      18 (34.41 cM)5
    1708261  NM_133249.21  NP_573512.11 
     612981365 
    chicken
    (Gallus gallus)
    Aves PPARGC1B1 peroxisome proliferator-activated receptor gamma, coactivator more 64.07(n)
    55.3(a)
      416148  XM_414479.4  XP_414479.4 
    lizard
    (Anolis carolinensis)
    Reptilia PPARGC1B6
    peroxisome proliferator-activated receptor gamma, ...
    46(a)
    1 ↔ 1
    2(122167164-122302129)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.201502 Xenopus laevis transcribed sequence with weak similarity more 76.65(n)    BQ736706.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570419462   -- 74.12(n)   368411  57041946 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spargel6
    Spargel
    11(a)
    1 → many
    3R(248205-255051)


    ENSEMBL Gene Tree for PPARGC1B (if available)
    TreeFam Gene Tree for PPARGC1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PPARGC1B gene
    PPRC12  PPARGC1A2  

    PPARGC1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    PRGC2_HUMAN, Q86YN6: Variation of PPARGC1B may contribute to the pathogenesis of obesity, with a widespread Ala-203
    allele being a risk factor for the development of this common disorders


    Selected SNPs for PPARGC1B (see all 2730)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs77326711,2,,4
    C,F,A,Hpathogenic1149488368(+) AGAAGG/CCTCCC 6 /P /A mis1 ese321Minor allele frequency- C:0.11EA NA NS CSA WA EU 7118
    rs1143932681,2
    C,F--144255010(+) GCTCTT/GCACCC 2 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1999673401,2
    --144277606(+) AATGT-/TTTA  
            
    TTTAC
    2 -- int10--------
    rs1406045921,2
    C--144277607(+) ATGTT-/TTATA 
            
    TTACT
    2 -- int10--------
    rs1427887301,2
    C--144282219(+) TATTG-/TTATTATT 2 -- int10--------
    rs1474106331,2
    C--144290762(+) TTTAT-/ATAG  
            
    ATAGA
    2 -- int10--------
    rs1830915051,2
    --144295256(+) GACTAC/TAGGCG 2 -- int10--------
    rs1862316211,2
    --144295258(+) CTACAA/GGCGCC 2 -- int10--------
    rs1905461341,2
    --144295260(+) ACAGGC/TGCCCA 2 -- int10--------
    rs288197421,2
    --144295272(+) CACCAC/TGCCTG 2 -- int10--------

    HapMap Linkage Disequilibrium report for PPARGC1B (149109815 - 149234585 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PPARGC1B (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730909CNV Deletion23290073
    esv1706104CNV Deletion17803354
    esv2730910CNV Deletion23290073
    nsv5061CNV Insertion18451855
    nsv5060CNV Loss18451855
    nsv462484CNV Loss19166990
    nsv462482CNV Loss19166990
    dgv727n27CNV Gain19166990
    nsv883024CNV Gain21882294
    esv32926CNV Gain17666407

    Human Gene Mutation Database (HGMD): PPARGC1B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPARGC1B
    DNA2.0 Custom Variant and Variant Library Synthesis for PPARGC1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608886   
    OMIM disorders: 601665  
    Selected diseases for PPARGC1B (see all 21):    About MalaCards
    obesity, variation in    vulvitis    obesity    diabetes mellitus
    familial breast cancer    mitochondrial disorders    morbid obesity    narcolepsy
    insulin resistance    myopathy    esophagitis    hepatitis b
    breast cancer    adenocarcinoma    thyroiditis    hepatitis
    prostate cancer    alzheimer's disease    pancreatitis    prostatitis


    PPARGC1B for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PPARGC1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 12.8 3 15863669 (2), 17579828 (1)

    Genetic Association Database (GAD): PPARGC1B
    Human Genome Epidemiology (HuGE) Navigator: PPARGC1B (20 documents)

    Export disorders for PPARGC1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PPARGC1B gene, integrated from 10 sources (see all 76):
    (articles sorted by number of sources associating them with PPARGC1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. (PubMed id 11854298)1, 2, 3, 9 Kressler D.... Kralli A. (J. Biol. Chem. 2002)
    2. Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. (PubMed id 15863669)1, 2, 4, 9 Andersen G.... Pedersen O. (J. Med. Genet. 2005)
    3. Impact of the peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1beta expression and fibre type composition in human skeletal muscle. (PubMed id 17579828)1, 4, 9 Ling C....Poulsen P. (Diabetologia 2007)
    4. Single-nucleotide polymorphisms within the antioxidant defence system and associations with aggressive prostate cancer. (PubMed id 20477822)1, 4 Abe M....Chan J.M. (BJU Int. 2011)
    5. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    6. Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. (PubMed id 20682687)1, 4 Jablonski K.A....Florez J.C. (Diabetes 2010)
    7. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    8. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. [The analysis of PPARGC1B gene polymorphism in athletes]. (PubMed id 20058823)1, 4 Akhmetov I.I....Rogozkin V.A. (Ross Fiziol Zh Im I M Sechenova 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 133522 HGNC: 30022 AceView: PPARGC1B Ensembl:ENSG00000155846 euGenes: HUgn133522
    ECgene: PPARGC1B H-InvDB: PPARGC1B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PPARGC1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PPARGC1B gene:
    Search GeneIP for patents involving PPARGC1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PPARGC1B   OriGene RNAi products in human, mouse, rat for PPARGC1B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PPARGC1B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PPARGC1B  
     OriGene qSTAR qPCR primer pairs in human, mouse for PPARGC1B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PPARGC1B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PPARGC1B   OriGene Custom Protein Services for PPARGC1B  

     
     
     Block miRNA regulation of human, mouse, rat PPARGC1B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PPARGC1B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPARGC1B Predesigned siRNA for gene silencing in human, mouse, rat PPARGC1B
     QuantiFast Probe-based Assays in human, mouse, rat PPARGC1B QuantiTect SYBR Green Assays in human, mouse, rat PPARGC1B
     PCR Arrays including human, mouse, rat PPARGC1B Search Chromatin IP Primers for PPARGC1B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPARGC1B  GeneGlobe Interaction Network for PPARGC1B
     Regulatory tfbs in PPARGC1B promoter
     GenScript Custom Purified and Recombinant Proteins Services for PPARGC1B GenScript cDNA clones with any tag delivered in your preferred vector for PPARGC1B
     GenScript Custom Assay Services for PPARGC1B GenScript Custom overexpressing Cell Line Services for PPARGC1B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PPARGC1B (PRGC2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PPARGC1B antibodies
     PPARGC1B proteins
     PPARGC1B lysates
     Antibodies for PPARGC1B
     See all of Abcam's Antibodies, Kits and Proteins for PPARGC1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for PPARGC1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPARGC1B
     SwitchGear 3'UTR luciferase reporter plasmids for PPARGC1B
     SwitchGear Promoter luciferase reporter plasmids for PPARGC1B
     ThermoFisher Antibody for PPARGC1B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPARGC1B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPARGC1B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPARGC1B
     LSBio Antibodies in human, mouse, rat for PPARGC1B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PPARGC1B gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4