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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPARGC1B Gene

protein-coding   GIFtS: 54
GCID: GC05P149109

peroxisome proliferator-activated receptor gamma, coactivator...

(Previous names: peroxisome proliferative activated receptor, gamma, coactivator...)
 Explore 19 diseases affiliated with
PPARGC1B via
MalaCards
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 Human Malady Compendium 
Biological research products
for PPARGC1B    

Aliases
for PPARGC1B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Beta1 2     ERRL12
PERC1 2 3 5     PGC-1(Beta)1
PGC1B1 2 3 5     Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Beta2
PPARGC-1-Beta1     PGC-1-Beta1
PGC-1-Related Estrogen Receptor Alpha Coactivator2 3     PGC13
PPAR-Gamma Coactivator 1-Beta2 3     PPARGC13
Peroxisome Proliferative Activated Receptor, Gamma, Coactivator 1, Beta1     

External Ids:    HGNC: 300221   Entrez Gene: 1335222   Ensembl: ENSG000001558467   OMIM: 6088865   UniProtKB: Q86YN63   

Export aliases for PPARGC1B gene to outside databases

Previous GC identifers: GC05P149138 GC05P149090 GC05P144256


Summaries
for PPARGC1B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PPARGC1B:
The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors,
including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may
be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein
is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene
increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: PRGC2_HUMAN, Q86YN6
Function: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates
transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in
the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as
suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat
oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure

Gene Wiki entry for PPARGC1B


Genomic Views
for PPARGC1B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPARGC1B gene promoter:
         Pax-3   STAT1   p300   AP-4   Nkx2-5   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPARGC1B promoter sequence
   Search SABiosciences Chromatin IP Primers for PPARGC1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPARGC1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q33.1

PPARGC1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPARGC1B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P149109:  view genomic region     (about GC identifiers)

Start:
 149,109,815 bp from pter      End:
 149,234,585 bp from pter
Size:
 124,771 bases      Orientation:
 plus strand

Proteins
for PPARGC1B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PRGC2_HUMAN, Q86YN6 (See protein sequence)
Recommended Name: Peroxisome proliferator-activated receptor gamma coactivator 1-beta  
Size: 1023 amino acids; 113222 Da
Subunit: Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor
1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with
estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16 (By similarity). Interacts with estrogen
receptor alpha/ESR1
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for PPARGC1B:
3SP6 (3D)    
Secondary accessions: A2RUM8 A2RUN0 B3KVW0 Q86YN3 Q86YN4 Q86YN5 Q8N1N9 Q8TDE4 Q8TDE5
Alternative splicing: 6 isoforms:  Q86YN6-1   Q86YN6-2   Q86YN6-3   Q86YN6-4   Q86YN6-5   Q86YN6-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPARGC1B: NX_Q86YN6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86YN6

    • PPARGC1B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001166169.1  NP_001166170.1  NP_573570.3  

    ENSEMBL proteins: 
     ENSP00000353638   ENSP00000377855   ENSP00000312649   ENSP00000384403   ENSP00000409364  
    Reactome Protein details: Q86YN6
    Human Recombinant Protein Products: 
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    Novus Biologicals PPARGC1B Protein
    Novus Biologicals PPARGC1B Lysate
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11854298
    GO:0005739mitochondrion IEA--
    GO:0016592mediator complex IDA11854298


    PPARGC1B for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for PPARGC1B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PPARGC1B for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q86YN6

    ProtoNet protein and cluster: Q86YN6

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: PRGC2_HUMAN, Q86YN6
    Domain: Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear
    receptors (By similarity)
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Function
    for PPARGC1B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PRGC2_HUMAN, Q86YN6
    Function: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates
    transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in
    the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as
    suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat
    oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure
    Induction: Repressed by saturated fatty acids such as palmitate and stearate in skeletal muscle cells. Induced by
    insulin and reduced by aging in skeletal muscle biopsies. Down-regulated in type 2 diabetes mellitus subjects as well
    as in pre-diabetics

    miRNA
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    8/245 QIAGEN miScript miRNA Assays for microRNAs that regulate PPARGC1B (see all 245):
    hsa-miR-194* hsa-miR-576-3p hsa-miR-579 hsa-miR-26a-2* hsa-miR-520f hsa-miR-106a hsa-miR-4275 hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmid: PPARGC1B 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0001104RNA polymerase II transcription cofactor activity IDA11854298
    GO:0003723RNA binding NAS11854298
    GO:0005515protein binding ----
    GO:0030331estrogen receptor binding IDA11854298


    PPARGC1B for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for PPARGC1B: Ppargc1btm1.1Rev Ppargc1btm1.1Dpk Ppargc1btm1.1Avp
         14 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Ppargc1b):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     muscle  no phenotypic analysis  respiratory system  skeleton 

    PPARGC1B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PPARGC1B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    		PPARA Activates Gene Expression0.74
    2Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    3Expression of ALAS1
    		Expression of ALAS11.00
    4SIDS Susceptibility Pathways
    		SIDS Susceptibility Pathways1.00
    5AMPK signaling
    		AMPK signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5 BioSystems Pathways for PPARGC1B 
        AMPK signaling
    SIDS Susceptibility Pathways
    SREBP signalling
    Mitochondrial Gene Expression
    Energy Metabolism

    5/6        Reactome Pathways for PPARGC1B (see all 6)
        Expression of ALAS1
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Metabolism
    PPARA Activates Gene Expression
    Fatty acid, triacylglycerol, and ketone body metabolism



    PPARGC1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPARGC1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for PPARGC1B (Q86YN63 ENSP000003126494) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRPPRCP427043, ENSP000002606654I2D: score=1 STRING: ENSP00000260665
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    FOXA2Q9Y2613, ENSP000003159554I2D: score=1 STRING: ENSP00000315955
    HNF4AP412353, ENSP000003129874I2D: score=1 STRING: ENSP00000312987
    PPARAQ078693, ENSP000002627354I2D: score=1 STRING: ENSP00000262735
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0006390transcription from mitochondrial promoter IEA--
    GO:0007015actin filament organization IEA--
    GO:0010694positive regulation of alkaline phosphatase activity IEA--
    GO:0030520intracellular estrogen receptor signaling pathway IDA11854298


    PPARGC1B for ontologies           About GeneDecksing



    Drugs & Compounds
    for PPARGC1B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPARGC1B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPARGC1B
    2 Novoseek chemical compound relationships for PPARGC1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fructose 47.3 1 19254570 (1)
    fatty acid 33.6 1 11733490 (1)

    Search CenterWatch for drugs/clinical trials and news about PPARGC1B / PRGC2 

    Transcripts
    for PPARGC1B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PPARGC1B gene (3 alternative transcripts): 
    NM_001172698.1  NM_001172699.1  NM_133263.3  

    Unigene Cluster for PPARGC1B:

    Peroxisome proliferator-activated receptor gamma, coactivator 1 beta
    Hs.483816  [show with all ESTs]
    Unigene Representative Sequence: NM_133263
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360453 ENST00000394320(uc003lrb.2 uc003lre.1) ENST00000461780
    ENST00000309241(uc003lrc.3 uc003lrd.3 uc021yfr.1 uc003lrf.3)
    ENST00000403750 ENST00000434684 ENST00000492495

    miRNA
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    8/245 QIAGEN miScript miRNA Assays for microRNAs that regulate PPARGC1B (see all 245):
    hsa-miR-194* hsa-miR-576-3p hsa-miR-579 hsa-miR-26a-2* hsa-miR-520f hsa-miR-106a hsa-miR-4275 hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmid: PPARGC1B 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF468496.1 AF468497.1 AK024346.1 AK095391.1 AK123614.1 AK123715.1 AY188947.1 AY188948.1 
    AY188949.1 AY188950.1 BC026956.1 BC132971.1 BC132973.1 BC144251.1 BX648997.1 

    13 DOTS entries:

    DT.97835483  DT.91925038  DT.100752442  DT.40260058  DT.100752441  DT.101963476  DT.97770463  DT.101957170 
    DT.40190389  DT.95247975  DT.40265079  DT.40265081  DT.436919 

    24/34 AceView cDNA sequences (see all 34):

    BM720077 BX283828 AY188948 AF056986 AW236547 NM_133263 AK123614 AK123715 
    AY188947 AF468497 AW811710 BU955896 AF468496 BM725569 AK095391 BM725763 
    CB962005 BU539125 BU739891 AY188950 AY188949 CB992747 BG829583 W70044 

    GeneLoc Exon Structure


    Expression
    for PPARGC1B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPARGC1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACTGTAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PPARGC1B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Brown adipocyte-like cells (Differentiation of w...)
    White adipocyte-like cells (Differentiation of w...)

    See PPARGC1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPARGC1B

    SOURCE GeneReport for Unigene cluster: Hs.483816

    UniProtKB/Swiss-Prot: PRGC2_HUMAN, Q86YN6
    Tissue specificity: Ubiquitous with higher expression in heart, brain and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including PPARGC1B: 
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Diabetes in human mouse rat
              PPAR Targets in human mouse rat
              Adipogenesis in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for PPARGC1B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PPARGC1B gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ppargc1b1 , 5 peroxisome proliferative activated receptor, gamma, more1, 5 82.8(n)1
    80.12(a)1    		   18 (34.41 cM)5
    1708261  NM_133249.21  NP_573512.11 
     612981365 
    chicken
    (Gallus gallus)    		 Aves PPARGC1B1 peroxisome proliferator-activated receptor gamma, coactivator more 64.39(n)
    56.28(a)    		   416148  XM_414479.3  XP_414479.3 
    lizard
    (Anolis carolinensis)    		 Reptilia PPARGC1B6
    		 --
    		 48(a)
    		 1 ↔ 1
    		 2(122167170-122207714)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.201502 Xenopus laevis transcribed sequence with weak similarity more 76.65(n)    BQ736706.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii 570419462   -- 74.12(n)   368411  57041946 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Spargel6
    		 Spargel
    		 8(a)
    		 1 → many
    		 3R(248205-255051)


    ENSEMBL Gene Tree for PPARGC1B (if available)
    TreeFam Gene Tree for PPARGC1B (if available) 

    Paralogs
    for PPARGC1B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPARGC1B gene
    PPRC12  PPARGC1A2  

    PPARGC1B for paralogs           About GeneDecksing



    Genomic Variants
    for PPARGC1B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: PRGC2_HUMAN, Q86YN6
    Polymorphism: Variation of PPARGC1B may contribute to the pathogenesis of obesity, with a widespread Ala-203 allele
    being a risk factor for the development of this common disorders


    10/2337 NCBI SNPs in PPARGC1B are shown (see all 2337)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs77326711,2
    		C,F,A,H,pathogenic156205287(+) AGAAGG/CCTCCC 6 /P /A mis1 ese321Minor allele frequency- C:0.11EA NA NS CSA WA EU 7118
    rs760970641,2
    		C,F,--144255243(+) GTGTTC/TAAGTC 2 -- us2k11Minor allele frequency- T:0.02EA 120
    rs737962371,2
    		C,--144255333(+) CAGCCC/TTTATG 2 -- us2k12Minor allele frequency- T:0.03WA 120
    rs801808311,2
    		C,F,--144255914(+) GCCCGT/CTGTGA 2 -- us2k11Minor allele frequency- C:0.06WA 118
    rs623822711,2
    		C,--144256648(+) CTTCTC/TGAGCC 2 -- us2k15Minor allele frequency- T:0.11NA CSA WA EA 362
    rs772090651,2
    		F,--144256978(+) GGCCTC/TACTCC 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs755369881,2
    		C,F,--144257798(+) TGGATG/AGGGGC 2 -- int15Minor allele frequency- A:0.11NA CSA WA EA 362
    rs623822721,2
    		C,F,--144258135(+) GAGTTA/CGGGCT 2 -- int15Minor allele frequency- C:0.11NA CSA WA EA 362
    rs38922851,2
    		C,F,A,--144258152(-) CGGGCG/ACCCAG 2 -- int14Minor allele frequency- A:0.46MN WA NA EA 542
    rs99861341,2
    		C,--144258169(+) GGTCAC/TTGGGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for PPARGC1B (149109815 - 149234585 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PPARGC1B
         1 CNV: 7476
    Human Gene Mutation Database (HGMD): PPARGC1B

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PPARGC1B
    DNA2.0 Custom Variant and Variant Library Synthesis for PPARGC1B

    Disorders / Diseases
    for PPARGC1B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PPARGC1B for disorders           About GeneDecksing

    OMIM gene information: 608886   
    OMIM disorders: 601665  
    19 diseases for PPARGC1B:    About MalaCards
    type 2 diabetes mellitus    diabetes mellitus    obesity    obesity, variation in
    vulvitis    insulin resistance    morbid obesity    familial breast cancer
    hepatitis b    breast cancer    twinning    prostate cancer
    hepatitis    esophagitis    cholesterol    prostatitis
    thyroiditis    adenocarcinoma    pancreatitis

    1 Novoseek disease relationship for PPARGC1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 12.8 3 15863669 (2), 17579828 (1)

    Genetic Association Database (GAD): PPARGC1B
    Human Genome Epidemiology (HuGE) Navigator: PPARGC1B (20 documents)

    Export disorders for PPARGC1B gene to outside databases

    Publications
    for PPARGC1B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPARGC1B gene, integrated from 9 sources (see all 65):
    (articles sorted by number of sources associating them with PPARGC1B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. (PubMed id 11854298)1, 2, 3, 9 Kressler D.... Kralli A. (2002)
    2. Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. (PubMed id 15863669)1, 2, 4, 9 Andersen G.... Pedersen O. (2005)
    3. Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro. (PubMed id 16132959)1, 2 Staiger H....Haering H.-U. (2005)
    4. Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins. (PubMed id 15546003)1, 2 Ling C.... Vaag A. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. (PubMed id 12832613)1, 2 Patti M.E....Mandarino L.J. (2003)
    7. Characterization of the human, mouse and rat PGC1 beta (peroxisome- proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo. (PubMed id 12678921)1, 2 Meirhaeghe A.... Vidal-Puig A.J. (2003)
    8. Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. (PubMed id 11793024)1, 3 Ek J....Pedersen O. (2001)
    9. Impact of the peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1beta expression and fibre type composition in human skeletal muscle. (PubMed id 17579828)1, 9 Ling C....Poulsen P. (2007)
    10. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. (PubMed id 11733490)1, 9 Lin J....Spiegelman B.M. (2002)

    External Searches for PPARGC1B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PPARGC1B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 133522 HGNC: 30022 AceView: PPARGC1B Ensembl:ENSG00000155846 euGenes: HUgn133522
    ECgene: PPARGC1B H-InvDB: PPARGC1B

    Other Databases showing PPARGC1B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PPARGC1B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPARGC1B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PPARGC1B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PPARGC1B gene:
    Search GeneIP for patents involving PPARGC1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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