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Aliases for PPARGC1B Gene

Aliases for PPARGC1B Gene

  • PPARG Coactivator 1 Beta 2 3
  • Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Beta 2 3 5
  • PGC-1-Related Estrogen Receptor Alpha Coactivator 3 4
  • PPAR-Gamma Coactivator 1-Beta 3 4
  • PPARgamma Coactivator 1 Beta 2 3
  • PPARGC-1-Beta 3 4
  • PGC1B 3 4
  • PERC 3 4
  • Peroxisome Proliferative Activated Receptor, Gamma, Coactivator 1, Beta 2
  • PGC-1(Beta) 3
  • PGC-1-Beta 4
  • PPARGC1 4
  • ERRL1 3
  • PGC1 4

External Ids for PPARGC1B Gene

Previous GeneCards Identifiers for PPARGC1B Gene

  • GC05P149138
  • GC05P149090
  • GC05P149109
  • GC05P144256

Summaries for PPARGC1B Gene

Entrez Gene Summary for PPARGC1B Gene

  • The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for PPARGC1B Gene

PPARGC1B (PPARG Coactivator 1 Beta) is a Protein Coding gene. Diseases associated with PPARGC1B include obesity and vulvitis. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PPARGC1A.

UniProtKB/Swiss-Prot for PPARGC1B Gene

  • Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.

Gene Wiki entry for PPARGC1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPARGC1B Gene

Genomics for PPARGC1B Gene

Regulatory Elements for PPARGC1B Gene

Promoters for PPARGC1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPARGC1B on UCSC Golden Path with GeneCards custom track

Genomic Location for PPARGC1B Gene

Chromosome:
5
Start:
149,730,252 bp from pter
End:
149,857,874 bp from pter
Size:
127,623 bases
Orientation:
Plus strand

Genomic View for PPARGC1B Gene

Genes around PPARGC1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPARGC1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPARGC1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPARGC1B Gene

Proteins for PPARGC1B Gene

  • Protein details for PPARGC1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YN6-PRGC2_HUMAN
    Recommended name:
    Peroxisome proliferator-activated receptor gamma coactivator 1-beta
    Protein Accession:
    Q86YN6
    Secondary Accessions:
    • A2RUM8
    • A2RUN0
    • B3KVW0
    • Q86YN3
    • Q86YN4
    • Q86YN5
    • Q8N1N9
    • Q8TDE4
    • Q8TDE5

    Protein attributes for PPARGC1B Gene

    Size:
    1023 amino acids
    Molecular mass:
    113222 Da
    Quaternary structure:
    • Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16 (By similarity). Interacts with estrogen receptor alpha/ESR1.

    Three dimensional structures from OCA and Proteopedia for PPARGC1B Gene

    Alternative splice isoforms for PPARGC1B Gene

neXtProt entry for PPARGC1B Gene

Proteomics data for PPARGC1B Gene at MOPED

Post-translational modifications for PPARGC1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPARGC1B Gene

Antibody Products

No data available for DME Specific Peptides for PPARGC1B Gene

Domains & Families for PPARGC1B Gene

Gene Families for PPARGC1B Gene

Protein Domains for PPARGC1B Gene

Graphical View of Domain Structure for InterPro Entry

Q86YN6

UniProtKB/Swiss-Prot:

PRGC2_HUMAN :
  • Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.
Domain:
  • Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with PPARGC1B: view

Function for PPARGC1B Gene

Molecular function for PPARGC1B Gene

UniProtKB/Swiss-Prot Function:
Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
UniProtKB/Swiss-Prot Induction:
Repressed by saturated fatty acids such as palmitate and stearate in skeletal muscle cells. Induced by insulin and reduced by aging in skeletal muscle biopsies. Down-regulated in type 2 diabetes mellitus subjects as well as in pre-diabetics.

Gene Ontology (GO) - Molecular Function for PPARGC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IDA 11854298
GO:0003676 nucleic acid binding IEA --
GO:0008134 transcription factor binding IBA --
GO:0030331 estrogen receptor binding IDA 11854298
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA 11854298
genes like me logo Genes that share ontologies with PPARGC1B: view
genes like me logo Genes that share phenotypes with PPARGC1B: view

Animal Models for PPARGC1B Gene

MGI Knock Outs for PPARGC1B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPARGC1B Gene

Localization for PPARGC1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPARGC1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPARGC1B Gene COMPARTMENTS Subcellular localization image for PPARGC1B gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 3
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for PPARGC1B Gene

Pathways & Interactions for PPARGC1B Gene

genes like me logo Genes that share pathways with PPARGC1B: view

Gene Ontology (GO) - Biological Process for PPARGC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0006390 transcription from mitochondrial promoter IEA --
GO:0006996 organelle organization TAS --
GO:0007005 mitochondrion organization TAS --
GO:0010694 positive regulation of alkaline phosphatase activity IEA --
genes like me logo Genes that share ontologies with PPARGC1B: view

No data available for SIGNOR curated interactions for PPARGC1B Gene

Drugs & Compounds for PPARGC1B Gene

(2) Drugs for PPARGC1B Gene - From: Novoseek and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2- methylphenoxy)acetic acid Pharma 0

(1) Additional Compounds for PPARGC1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PPARGC1B: view

Transcripts for PPARGC1B Gene

Unigene Clusters for PPARGC1B Gene

Peroxisome proliferator-activated receptor gamma, coactivator 1 beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPARGC1B Gene

No ASD Table

Relevant External Links for PPARGC1B Gene

GeneLoc Exon Structure for
PPARGC1B
ECgene alternative splicing isoforms for
PPARGC1B

Expression for PPARGC1B Gene

mRNA expression in normal human tissues for PPARGC1B Gene

SOURCE GeneReport for Unigene cluster for PPARGC1B Gene Hs.483816

mRNA Expression by UniProt/SwissProt for PPARGC1B Gene

Q86YN6-PRGC2_HUMAN
Tissue specificity: Ubiquitous with higher expression in heart, brain and skeletal muscle.
genes like me logo Genes that share expression patterns with PPARGC1B: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PPARGC1B Gene

Orthologs for PPARGC1B Gene

This gene was present in the common ancestor of animals.

Orthologs for PPARGC1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPARGC1B 35
  • 99.48 (n)
  • 99.32 (a)
PPARGC1B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPARGC1B 36
  • 79 (a)
OneToOne
PPARGC1B 35
  • 86.24 (n)
  • 84.36 (a)
dog
(Canis familiaris)
Mammalia PPARGC1B 35
  • 88.33 (n)
  • 86.43 (a)
PPARGC1B 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppargc1b 16
Ppargc1b 35
  • 82.74 (n)
  • 79.5 (a)
Ppargc1b 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPARGC1B 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPARGC1B 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppargc1b 35
  • 81.91 (n)
  • 78.4 (a)
chicken
(Gallus gallus)
Aves PPARGC1B 36
  • 45 (a)
OneToOne
PPARGC1B 35
  • 64.07 (n)
  • 55.3 (a)
lizard
(Anolis carolinensis)
Reptilia PPARGC1B 36
  • 46 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20150 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ppargc1b 35
  • 55.31 (n)
  • 50.29 (a)
Str.17645 35
zebrafish
(Danio rerio)
Actinopterygii ppargc1b 36
  • 31 (a)
OneToOne
-- 35
ppargc1b 35
  • 52.88 (n)
  • 43.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spargel 36
  • 11 (a)
OneToMany
Species with no ortholog for PPARGC1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPARGC1B Gene

ENSEMBL:
Gene Tree for PPARGC1B (if available)
TreeFam:
Gene Tree for PPARGC1B (if available)

Paralogs for PPARGC1B Gene

Paralogs for PPARGC1B Gene

genes like me logo Genes that share paralogs with PPARGC1B: view

Variants for PPARGC1B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PPARGC1B Gene

Q86YN6-PRGC2_HUMAN
Variation of PPARGC1B may contribute to the pathogenesis of obesity, with a widespread Ala-203 allele being a risk factor for the development of this common disorders.

Sequence variations from dbSNP and Humsavar for PPARGC1B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs7732671 - 149,832,680(+) AGAAG(C/G)CTCCC reference, missense, utr-variant-5-prime
rs45520937 - 149,832,867(+) TCCCC(A/G)GGACT reference, missense
rs17572019 - 149,832,908(+) CCCCG(A/G)TTTCC reference, missense
rs11959820 - 149,832,947(+) TCATA(A/C/T)GCTAC reference, missense
rs26123 -- 149,851,769(-) CTCTG(A/C)AGCTC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PPARGC1B Gene

Variant ID Type Subtype PubMed ID
nsv5060 CNV Loss 18451855
esv32926 CNV Gain 17666407
nsv5061 CNV Insertion 18451855
esv2730909 CNV Deletion 23290073
esv1706104 CNV Deletion 17803354
esv2730910 CNV Deletion 23290073
nsv462482 CNV Loss 19166990
nsv462484 CNV Loss 19166990
nsv883024 CNV Gain 21882294
dgv727n27 CNV Gain 19166990
esv24664 CNV Gain+Loss 19812545

Variation tolerance for PPARGC1B Gene

Residual Variation Intolerance Score: 86.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.79; 86.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPARGC1B Gene

HapMap Linkage Disequilibrium report
PPARGC1B
Human Gene Mutation Database (HGMD)
PPARGC1B

Disorders for PPARGC1B Gene

MalaCards: The human disease database

(5) MalaCards diseases for PPARGC1B Gene - From: OMIM, GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
obesity
  • obesity, association with
vulvitis
vulvar disease
  • vulvar diseases
reticulate acropigmentation of kitamura
  • rapk
mitochondrial disorders
  • mitochondrial encephalomyopathies
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PPARGC1B

Genetic Association Database (GAD)
PPARGC1B
Human Genome Epidemiology (HuGE) Navigator
PPARGC1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPARGC1B
genes like me logo Genes that share disorders with PPARGC1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPARGC1B Gene

Publications for PPARGC1B Gene

  1. The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. (PMID: 11854298) Kressler D. … Kralli A. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. Impact of the peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1beta expression and fibre type composition in human skeletal muscle. (PMID: 17579828) Ling C. … Poulsen P. (Diabetologia 2007) 3 23
  3. Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. (PMID: 15863669) Andersen G. … Pedersen O. (J. Med. Genet. 2005) 3 23
  4. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. (PMID: 11733490) Lin J. … Spiegelman B.M. (J. Biol. Chem. 2002) 3 23
  5. Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. (PMID: 11793024) Ek J. … Pedersen O. (Diabetologia 2001) 2 3

Products for PPARGC1B Gene

Sources for PPARGC1B Gene

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