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Aliases for PPARGC1A Gene

Aliases for PPARGC1A Gene

  • Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha 2 3
  • PPARGC1 3 4 6
  • PPARGC-1-Alpha 3 4
  • PGC-1-Alpha 3 4
  • PGC1A 3 4
  • LEM6 3 4
  • PGC1 3 4
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Alpha Transcript Variant B4-3ext 3
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Alpha Transcript Variant B4-8a 3
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Alpha Transcript Variant B5-NT 3
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Alpha Transcript Variant B4 3
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Alpha Transcript Variant B5 3
  • Peroxisome Proliferative Activated Receptor, Gamma, Coactivator 1, Alpha 2
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha 3
  • Peroxisome Proliferative Activated Receptor, Gamma, Coactivator 1 2
  • PPAR Gamma Coactivator Variant Form 3
  • PPAR-Gamma Coactivator 1-Alpha 4
  • Ligand Effect Modulator-6 3
  • Ligand Effect Modulator 6 4
  • L-PGC-1alpha 3
  • PGC-1(Alpha) 3
  • PGC-1v 3

External Ids for PPARGC1A Gene

Previous Symbols for PPARGC1A Gene

  • PPARGC1

Summaries for PPARGC1A Gene

Entrez Gene Summary for PPARGC1A Gene

  • The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPARGC1A Gene

PPARGC1A (Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha) is a Protein Coding gene. Diseases associated with PPARGC1A include lipomatosis and obesity. Among its related pathways are L1CAM interactions and GPCR Pathway. GO annotations related to this gene include RNA binding and transcription factor binding. An important paralog of this gene is PPARGC1B.

UniProtKB/Swiss-Prot for PPARGC1A Gene

  • Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.

Gene Wiki entry for PPARGC1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPARGC1A Gene

Genomics for PPARGC1A Gene

Genomic Location for PPARGC1A Gene

Start:
23,755,041 bp from pter
End:
24,091,635 bp from pter
Size:
336,595 bases
Orientation:
Minus strand

Genomic View for PPARGC1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPARGC1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPARGC1A Gene

Regulatory Elements for PPARGC1A Gene

Proteins for PPARGC1A Gene

  • Protein details for PPARGC1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBK2-PRGC1_HUMAN
    Recommended name:
    Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
    Protein Accession:
    Q9UBK2
    Secondary Accessions:
    • B7Z406
    • G8DM16
    • I3RTT5
    • I3RTT6
    • I3RTT7
    • I3RTT8
    • I3RTT9
    • Q3LIG1
    • Q4W5M7
    • Q9UN32

    Protein attributes for PPARGC1A Gene

    Size:
    798 amino acids
    Molecular mass:
    91027 Da
    Quaternary structure:
    • Homooligomer. Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation (By similarity). Interacts with PRDM16, LPIN1 and PML (By similarity). Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation (By similarity). Interacts with LRPPRC. Interacts with RNF34 (via RING-type zinc finger).

    Three dimensional structures from OCA and Proteopedia for PPARGC1A Gene

    Alternative splice isoforms for PPARGC1A Gene

neXtProt entry for PPARGC1A Gene

Proteomics data for PPARGC1A Gene at MOPED

Post-translational modifications for PPARGC1A Gene

  • Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions
  • Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.
  • Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPARGC1A Gene

No data available for DME Specific Peptides for PPARGC1A Gene

Domains for PPARGC1A Gene

Gene Families for PPARGC1A Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for PPARGC1A Gene

UniProtKB/Swiss-Prot:

PRGC1_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q9UBK2
genes like me logo Genes that share domains with PPARGC1A: view

Function for PPARGC1A Gene

Molecular function for PPARGC1A Gene

UniProtKB/Swiss-Prot Function: Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.
UniProtKB/Swiss-Prot Induction: Transcription is repressed by ZNF746 which binds to insulin response sequences its promoter.

Gene Ontology (GO) - Molecular Function for PPARGC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001104 RNA polymerase II transcription cofactor activity TAS 14636573
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding TAS 10713165
GO:0003682 chromatin binding --
genes like me logo Genes that share ontologies with PPARGC1A: view
genes like me logo Genes that share phenotypes with PPARGC1A: view

Animal Models for PPARGC1A Gene

MGI Knock Outs for PPARGC1A:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PPARGC1A Gene

Localization for PPARGC1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPARGC1A Gene

Isoform 1: Nucleus. Nucleus, PML body.
Isoform B4: Nucleus.
Isoform B4-8a: Cytoplasm. Nucleus.
Isoform B5: Nucleus. Nucleus, PML body.
Isoform 9: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPARGC1A Gene COMPARTMENTS Subcellular localization image for PPARGC1A gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for PPARGC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 12588810
GO:0005654 nucleoplasm TAS --
GO:0005665 DNA-directed RNA polymerase II, core complex TAS 12588810
GO:0005829 cytosol IEA --
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with PPARGC1A: view

Pathways for PPARGC1A Gene

genes like me logo Genes that share pathways with PPARGC1A: view

Pathways by source for PPARGC1A Gene

Gene Ontology (GO) - Biological Process for PPARGC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis TAS 1258810
GO:0001666 response to hypoxia --
GO:0001678 cellular glucose homeostasis NAS 11854298
GO:0006012 galactose metabolic process IEA --
GO:0006094 gluconeogenesis NAS 11854298
genes like me logo Genes that share ontologies with PPARGC1A: view

Compounds for PPARGC1A Gene

(37) Novoseek inferred chemical compound relationships for PPARGC1A Gene

Compound -log(P) Hits PubMed IDs
pgc1 87.8 13
fatty acid 67 46
aicar 62.8 5
glucose 60.2 70
androstane 53.3 1
genes like me logo Genes that share compounds with PPARGC1A: view

Transcripts for PPARGC1A Gene

Unigene Clusters for PPARGC1A Gene

Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPARGC1A Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12 ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - - -
SP8:
SP9:
SP10:

ExUns: 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PPARGC1A Gene

GeneLoc Exon Structure for
PPARGC1A
ECgene alternative splicing isoforms for
PPARGC1A

Expression for PPARGC1A Gene

mRNA expression in normal human tissues for PPARGC1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPARGC1A Gene

This gene is overexpressed in Heart - Atrial Appendage (6.0), Muscle - Skeletal (5.1), Heart - Left Ventricle (4.8), and Liver (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PPARGC1A Gene

SOURCE GeneReport for Unigene cluster for PPARGC1A Gene Hs.527078

mRNA Expression by UniProt/SwissProt for PPARGC1A Gene

Q9UBK2-PRGC1_HUMAN
Tissue specificity: Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.
genes like me logo Genes that share expressions with PPARGC1A: view

Orthologs for PPARGC1A Gene

This gene was present in the common ancestor of animals.

Orthologs for PPARGC1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPARGC1A 36
  • 99.18 (n)
  • 98.83 (a)
PPARGC1A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPARGC1A 36
  • 93.79 (n)
  • 94.59 (a)
PPARGC1A 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPARGC1A 36
  • 95.64 (n)
  • 96.98 (a)
PPARGC1A 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppargc1a 36
  • 92.25 (n)
  • 94.85 (a)
Ppargc1a 16
Ppargc1a 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPARGC1A 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPARGC1A 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppargc1a 36
  • 92.5 (n)
  • 95.35 (a)
chicken
(Gallus gallus)
Aves PPARGC1A 36
  • 86.08 (n)
  • 89.06 (a)
PPARGC1A 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPARGC1A 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppargc1a 36
  • 77.18 (n)
  • 78.12 (a)
zebrafish
(Danio rerio)
Actinopterygii ppargc1a 37
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Spargel 37
  • 13 (a)
OneToMany
Species with no ortholog for PPARGC1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPARGC1A Gene

ENSEMBL:
Gene Tree for PPARGC1A (if available)
TreeFam:
Gene Tree for PPARGC1A (if available)

Paralogs for PPARGC1A Gene

Paralogs for PPARGC1A Gene

genes like me logo Genes that share paralogs with PPARGC1A: view

Variants for PPARGC1A Gene

Sequence variations from dbSNP and Humsavar for PPARGC1A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs581528 -- 24,023,135(-) TATAA(C/T)AACCA intron-variant
rs581550 -- 24,023,115(-) CATGA(A/T)TAATG intron-variant
rs582394 -- 23,990,928(-) CAGTG(C/T)TTTGG intron-variant
rs582581 -- 24,022,867(-) GATAC(A/G)GTTAA intron-variant
rs582804 -- 23,990,850(-) GACGT(G/T)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPARGC1A Gene

Variant ID Type Subtype PubMed ID
nsv290453 CNV Insertion 16902084
esv269130 CNV Insertion 20981092

Relevant External Links for PPARGC1A Gene

HapMap Linkage Disequilibrium report
PPARGC1A
Human Gene Mutation Database (HGMD)
PPARGC1A

Disorders for PPARGC1A Gene

(1) University of Copenhagen DISEASES for PPARGC1A Gene

(27) Novoseek inferred disease relationships for PPARGC1A Gene

Disease -log(P) Hits PubMed IDs
insulin resistance 63.1 33
insulin sensitivity 62 20
obesity 52.6 26
metabolic disorder 49.2 2
niddm 42.9 15

Relevant External Links for PPARGC1A

Genetic Association Database (GAD)
PPARGC1A
Human Genome Epidemiology (HuGE) Navigator
PPARGC1A
genes like me logo Genes that share disorders with PPARGC1A: view

No data available for UniProtKB/Swiss-Prot for PPARGC1A Gene

Publications for PPARGC1A Gene

  1. Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. (PMID: 10585775) Esterbauer H. … Patsch W. (Genomics 1999) 2 3 4 23
  2. Cloning and mRNA tissue distribution of human PPARgamma coactivator- 1. (PMID: 10643692) Larrouy D. … Langin D. (Int. J. Obes. Relat. Metab. Disord. 1999) 3 4 23
  3. Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with obesity indices in middle-aged women. (PMID: 11916956) Esterbauer H. … Patsch W. (Diabetes 2002) 3 23 49
  4. A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. (PMID: 12606537) Muller Y.L. … Baier L. (Diabetes 2003) 3 23 49
  5. The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populations. (PMID: 15146371) Stumvoll M. … HAoring H. (Exp. Clin. Endocrinol. Diabetes 2004) 3 23 49

Products for PPARGC1A Gene

Sources for PPARGC1A Gene

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