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PPARG Gene

protein-coding GIFtS: 73

GC03P012305

peroxisome proliferator-activated receptor gamma
(Previous names: peroxisome proliferative activated receptor, gamma )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases & Descriptions
peroxisome proliferator-activated receptor gamma¹ ²		GLM1² ⁵
NR1C3¹ ² ³		CIMT1² ⁵
PPARG2¹ ² ⁵		peroxisome proliferative activated receptor, gamma¹
PPARG1¹ ² ⁵		PPAR gamma²
PPARgamma¹ ²		peroxisome proliferative activated receptor gamma²
Nuclear receptor subfamily 1 group C member 3² ³		peroxisome proliferator-activated receptor gamma 1²
PPAR-gamma² ³

External Ids:	HGNC: 9236¹	Entrez Gene: 5468²	Ensembl: ENSG00000132170⁷	UniProtKB: P37231³

Search outside databases for aliases for PPARG gene

Previous GC identifers: GC03P012258 GC03P012304

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPARG:

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors.

PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various

genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is

PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the

pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced

transcript variants that encode different isoforms have been described. (provided by RefSeq)

UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231

Function: Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a

ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It

therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation

and glucose homeostasis

summary for PPARG:

Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear receptor family of

ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate

gene expression. PPARgamma is located primarily in the adipose tissue, lymphoid tissue, colon, liver and

heart and is thought to regulate adipocyte differentiation and glucose homeostasis. PPARgamma has been

implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer.

The human gene encoding PPARgamma has been localized to chromosome 3 (3p25).

Gene Wiki entry for PPARG (Peroxisome proliferator-activated receptor gamma)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PPARG gene upstream (promoter) region

:
deltaCREB CREB Egr-1 C/EBPalpha FOXO1a Oct-B1 POU2F2C POU2F2 POU2F1 oct-B3

Epigenetics:

Search SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for PPARG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25 Ensembl cytogenetic band: 3p25.2 HGNC cytogenetic band: 3p25

PPARG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P012305: view genomic region (about GC identifiers)

Start:	12,328,867 bp from pter
End:	12,475,855 bp from pter
Size:	146,989 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.11 NT_022517.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231 (See protein sequence)

Recommended Name: Peroxisome proliferator-activated receptor gamma

Size: 505 amino acids; 57620 Da

Subunit: Forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor ARF6.

Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with

coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with FAM120B. Interacts

with PRDM16 (By similarity). Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 LXXLL motifs.

Interacts with TGFB1I1. Interacts with DNTTIP2

Subcellular location: Nucleus

Sequence caution: Sequence=AAN38992.2; Type=Erroneous initiation; Sequence=BAA23354.1; Type=Erroneous gene model

prediction; Sequence=BAF83270.1; Type=Erroneous initiation; Sequence=CAA62153.1; Type=Erroneous initiation;

PDB structures from and Proteopedia :

1FM6 (3D)

1FM9 (3D)

1I7I (3D)

1K74 (3D)

1KNU (3D)

1NYX (3D)

1PRG (3D)

1RDT (3D)

1WM0 (3D)

1ZEO (3D)

1ZGY (3D)

2ATH (3D)

2F4B (3D)

2FVJ (3D)

2G0G (3D)

2G0H (3D)

2GTK (3D)

2HFP (3D)

2HWQ (3D)

2HWR (3D)

2I4J (3D)

2I4P (3D)

2I4Z (3D)

2OM9 (3D)

2P4Y (3D)

2POB (3D)

2PRG (3D)

2Q59 (3D)

2Q5P (3D)

2Q5S (3D)

2Q61 (3D)

2Q6R (3D)

2Q6S (3D)

2Q8S (3D)

2QMV (3D)

2VSR (3D)

2VST (3D)

2VV0 (3D)

2VV1 (3D)

2VV2 (3D)

2VV3 (3D)

2VV4 (3D)

2ZK0 (3D)

2ZK1 (3D)

2ZK2 (3D)

2ZK3 (3D)

2ZK4 (3D)

2ZK5 (3D)

2ZK6 (3D)

2ZNO (3D)

2ZVT (3D)

3B3K (3D)

3BC5 (3D)

3CDP (3D)

3CDS (3D)

3CS8 (3D)

3CWD (3D)

3D6D (3D)

3DZU (3D)

3DZY (3D)

3E00 (3D)

3ET0 (3D)

3ET3 (3D)

3FEJ (3D)

3FUR (3D)

3G9E (3D)

3GBK (3D)

3H0A (3D)

3HO0 (3D)

3HOD (3D)

3IA6 (3D)

3K8S (3D)

3KMG (3D)

3PRG (3D)

4PRG (3D)

Secondary accessions: A8K3G6 B5BUA1 O00684 O00710 O14515 Q15178 Q15179 Q15180 Q15832 Q86U60 Q96J12

Alternative splicing: 2 isoforms: P37231-1 P37231-2 (Additional isoforms seem to exist)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_005028.4 NP_056953.2 NP_619725.2 NP_619726.2

ENSEMBL proteins:

ENSP00000380194 ENSP00000400017 ENSP00000380224 ENSP00000392285 ENSP00000380195 ENSP00000380210

ENSP00000380198 ENSP00000380218 ENSP00000380196 ENSP00000312472 ENSP00000380201 ENSP00000380221

ENSP00000380205 ENSP00000380207 ENSP00000287820 ENSP00000411931

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	HuPro® and/or Recombinant Proteins from Abnova for PPARG
	Origene Purified Recombinant Human Proteins (see all 3): PPARG
	Novus Biologicals Proteins for PPARG
	Novus Biologicals Lysates for PPARG
	Browse Sino Biological Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	9568716
GO:0005829	cytosol	ISS	--

About this table

PPARG for ontologies About GeneDecksing

Antibodies for PPARG:

	Millipore Mono- and Polyclonal Antibodies for the study of PPARG
	Sigma-Aldrich Antibodies for PPARG
	R&D Systems Antibodies for PPARG (PPAR gamma/NR1C3)
	Cell Signaling Technology (CST) Antibodies for PPARG (PPARgamma)
	Monoclonal and Polyclonal Antibodies from Abnova (PPARG)
	Browse Origene Antibodies
	Novus Biologicals Antibodies for PPARG
	Browse antibodies at Epitomics

Assays for PPARG:

	Millipore Kits and Assays for the Analysis of PPARG
	Browse ELISAs at Sigma-Aldrich
	Browse R&D Systems for biochemical assays
	Browse Enzo Life Sciences for kits & assays

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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PPARG for domains About GeneDecksing

5/7 InterPro domains/families (see all 7 ):

IPR008946 Nucl_hormone_rcpt_ligand-bd

IPR003077 1Cnucl_rcpt_G

IPR001723 Str_hrmn_rcpt

IPR003074 1Cnucl_rcpt

IPR013088 Znf_NHR/GATA

Graphical View of Domain Structure for InterPro Entry P37231

ProtoNet protein and cluster: P37231

3 Blocks protein families:

IPB001723 Steroid hormone receptor signature

IPB003074 Peroxisome proliferator-activated receptor (1C nuclear receptor) signature

IPB003077 Peroxisome proliferator-activated receptor gamma signature

UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231

Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib. RNA:		Millipore RNAi Products for the Analysis of PPARG Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (PPARG)
		Origene 29mer shRNA kits in GFP-retroviral vector (see all 4): PPARG Origene shRNA RFP (see all 4): PPARG Origene basic RS shRNA (see all 4): PPARG
		Applied Biosystems Silencer® siRNAs for PPARG
		Sigma-Aldrich siRNA Panels and siRNA for PPARG Sigma-Aldrich shRNA Panels and shRNA for PPARG Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		Origene GFP tagged cDNA clones in CMV expression vector (see all 4): PPARG Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): PPARG Origene untagged cDNA clones in CMV expression vector (see all 8): PPARG
		Browse Sino Biological Human cDNA Clones

UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231

Function: Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a

ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It

therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation

and glucose homeostasis

Genatlas biochemistry entry for PPARG:

peroxisome proliferator-activated receptor,steroid/thyroid hormone coactivator receptor superfamily,heterodimerizing

with RXR*,coactivated by SRCO1,expressed (isoform 1) in the diploid trophoblast lineages and required for placental

development,expressed at low levels in preadipocytes,induced by CEBPB and CEBPD,coexpressed with and coregulated by

PPARG,jointly required for full adipocyte differentiation and fat deposition with variability influencing plasma

leptin levels in obese humans,modulator of insulin sensitivity and control of glucose homostasis and blood pressure

and activation of antidiabetic effect of thiazolidinediones,negative regulator of macrophage activation,inhibiting

production of monocyte inflammatory cytokines,increasing PAI1 expression in endothelial cells.

5/19 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 19 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	ISS	--
GO:0003682	chromatin binding	--	--
GO:0003700	transcription factor activity	ISS	--
GO:0003707	steroid hormone receptor activity	IEA	--
GO:0004879	ligand-dependent nuclear receptor activity	IDA	10622252

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PPARG for ontologies About GeneDecksing

Animal Models: 15/26 MGI mutant phenotypes (inferred from 28 alleles) (MGI details for Pparg) (see all 26 ):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system
homeostasis/metabolism	immune system	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging

PPARG for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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PPARG for pathways About GeneDecksing

3 Millipore Pathways for PPARG

	Transcription PPAR Pathway
	Development Beta-adrenergic receptors signaling via cAMP
	Immune response Oncostatin M signaling via MAPK in human cells

5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for PPARG (Your Favorite Gene powered by Ingenuity) (see all 7 )

	ERK/MAPK Signaling
	Type II Diabetes Mellitus Signaling
	PPAR Signaling
	FXR/RXR Activation
	Thyroid Cancer Signaling

2 GeneAssist Pathways for PPARG

	PPAR Pathway
	Polyamine Regulation in Colon Cancer

2 Cell Signaling Technology (CST) Pathways for PPARG:

	NF-kB Signaling
	MAPK/Erk in Growth and Differentiation

4 Kegg Pathways (Kegg details for PPARG):

	hsa03320 PPAR signaling pathway
	hsa05016 Huntington's disease
	hsa05200 Pathways in cancer
	hsa05216 Thyroid cancer

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PPARG

5/34 Interacting proteins for PPARG (P37231^{1, 2} ENSP00000287820³) via UniProtKB, MINT, and/or STRING (see all 34 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPARGC1A	Q9UBK2², ENSP00000264867³	MINT-7229698 MINT-7229685 STRING: ENSP00000264867
EP300	Q09472¹, ENSP00000263253³	EBI-781384,EBI-447295 STRING: ENSP00000263253
MED1	Q15648¹, ENSP00000300651³	EBI-781384,EBI-394459 STRING: ENSP00000300651
EDF1	O60869¹	EBI-781384,EBI-781301
SMARCA4	P51532¹	EBI-781384,EBI-302489

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5/50 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 50 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	ISS	--
GO:0001818	negative regulation of cytokine production	IEA	--
GO:0001890	placenta development	ISS	--
GO:0002674	negative regulation of acute inflammatory response	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--

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PPARG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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PPARG for compounds About GeneDecksing

Enzo Life Sciences drugs & compounds for PPARG

Sigma-Aldrich Small Molecules for PPARG:

Small Molecule - Antagonist Small Molecule - Agonist Small Molecule - Mixed Agonist/Antagonist Small Molecule - Activator

Compounds for PPARG available from Tocris Bioscience

Compound	Action	CAS number
Troglitazone	Selective PPARgamma agonist; antidiabetic agent	[97322-87-7]
BADGE	PPARgamma antagonist	[1675-54-3]
GW 1929 hydrochloride	Selective PPARgamma agonist. Orally active	[196808-24-9]
nTZDpa	Potent, selective PPARgamma partial agonist	[118414-59-8]
T 0070907	Highly potent and selective PPARgamma antagonist	[313516-66-4]

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10/899 Novoseek chemical compound relationships for PPARG gene (see all 899 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gw9662	100.00	397	16696951 (6), 12022867 (6), 18566752 (3), 18203887 (3) (see all 100)
ciglitazone	100.00	414	19288012 (5), 18780770 (5), 17494862 (5), 12697971 (5) (see all 100)
pioglitazone	100.00	675	19281808 (6), 17643887 (5), 19737384 (4), 19506796 (4) (see all 100)
15-deoxy-delta-12,14-prostaglandin j2	100.00	843	15254749 (8), 17643887 (6), 16198309 (6), 12970094 (6) (see all 100)
thiazolidinedione	100.00	369	12694805 (12), 10075686 (6), 9832442 (5), 17390024 (4) (see all 100)
troglitazone	100.00	853	10871190 (8), 9709955 (7), 16303758 (7), 12475986 (6) (see all 100)
telmisartan	100.00	216	19822796 (8), 18250362 (6), 19635982 (5), 19590508 (5) (see all 100)
rosiglitazone	100.00	1382	17622750 (7), 18630997 (6), 18261208 (6), 12970094 (6) (see all 100)
bisphenol a diglycidyl ether	76.71	53	11991651 (5), 11879183 (4), 11030710 (3), 15992368 (2) (see all 41)
gw1929	70.32	33	19420904 (2), 18097603 (2), 16484545 (2), 15677767 (2) (see all 29)

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3 PharmGKB drug compound relationships for PPARG gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
glitazones	PD GN	11966407
insulin	PD	9806549
rosiglitazone	PD	15181049

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Millipore RNAi Products for the Analysis of PPARG Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (PPARG)
		Applied Biosystems Silencer® siRNAs: NM_005037 NM_015869 NM_138711 NM_138712
		Origene 29mer shRNA kits in GFP-retroviral vector (see all 4): PPARG Origene shRNA RFP (see all 4): PPARG Origene basic RS shRNA (see all 4): PPARG
		Sigma-Aldrich siRNA Panels and siRNA for PPARG Sigma-Aldrich shRNA Panels and shRNA for PPARG Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:		8 SABiosciences microRNAs that regulate PPARG:
		hsa-miR-128b hsa-miR-454 hsa-miR-27a hsa-miR-128 hsa-miR-130a hsa-miR-301a hsa-miR-27b hsa-miR-130b

Assays:

Applied Biosystems TaqMan® Gene Expression Assays:

NM_005037 NM_015869 NM_138711 NM_138712

Clones:

Origene GFP tagged cDNA clones in CMV expression vector (see all 4): PPARG
Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): PPARG
Origene untagged cDNA clones in CMV expression vector (see all 8): PPARG

Primers:		Origene genome-wide validated SYBR primer pairs: PPARG
		SABiosciences RT2 qPCR Primer Assay for PPARG: PPH02291A

REFSEQ mRNAs for PPARG gene (4 alternative transcripts):

NM_005037.5 NM_015869.4 NM_138711.3 NM_138712.3

Additional cDNA sequence:

AB097931.1 AB107271.1 AB307692.1 AB451337.1 AB451486.1 AB472042.1 AJ563369.1 AJ563370.1

AJ698135.1 AK223528.1 AK290581.1 BC006811.1 BT007281.1 CR599329.1 CR605352.1 CR609113.1

CR609454.1 CR622226.1 D83233.1 DQ356894.1 U63415.1 U79012.1 X90563.1

11 DOTS entries:

DT.112942 DT.100791623 DT.100791622 DT.100791631 DT.75152583 DT.120867762 DT.97811244 DT.100791626

DT.100791629 DT.120867823 DT.95371767

24/116 AceView cDNA sequences (see all 116 ):

BQ722874 BM995901 CD101663 BQ021210 BQ012686 NM_005037 AB107271 BI761688

AI200451 CR599329 BG742110 BU526666 AL549037 U63415 AL543579 BU626490

BM790089 BU618129 AW628342 BF514811 CB133173 NM_138711 BQ012901 AI355115

highest scoring ESTs for PPARG:

AA053166 AA088420 AA558472 AA625223 AI123591 AI280895 AI280973 AI339791 AI355115 AI749134

Unigene Cluster for PPARG:

Peroxisome proliferator-activated receptor gamma

Hs.162646 [show with all ESTs]

Unigene Representative Sequence: AB472042

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PPARG (see all 9 )

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	^	10a	·	10b	^	11	^	12	^	13a	·	13b	·	13c
SP1:											-		-						-
SP2:							-		-		-		-		-		-		-
SP3:
SP4:																			-																				-
SP5:							-		-		-		-						-

About this scheme

ECgene alternative splicing isoforms for PPARG

18 Ensembl transcripts including schematic representations:

ENST00000396998 ENST00000429166 ENST00000397029 ENST00000438682 ENST00000396999 ENST00000397015

ENST00000477039 ENST00000397003 ENST00000397023 ENST00000397000 ENST00000497594 ENST00000309576

ENST00000397006 ENST00000397026 ENST00000397010 ENST00000397012 ENST00000287820 ENST00000455517

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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PPARG expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PPARG

¹ / ² / ³

3 probe-sets matching PPARG gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37104_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L40904	0.80	1.00	0.91	1
208510_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_015869	0.60	1.00	0.82	1
208510_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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PPARG for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: AGTCTTCACC

SOURCE GeneReport for Unigene cluster: Hs.162646

UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231

Tissue specificity: Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also

detectable in placenta, lung and ovary

Primers:		Origene genome-wide validated SYBR primer pairs: PPARG
		SABiosciences RT2 qPCR Primer Assay for PPARG: PPH02291A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for PPARG gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PPARG¹	--	peroxisome proliferator-activated receptor gamma	92.34(n) 98.22(a)	403606 NM_001024632.1 NP_001019803.1
chimpanzee (Pan troglodytes)	PPARG¹	--	peroxisome proliferator-activated receptor gamma	99.54(n) 99.8(a)	460178 XM_001153669.1 XP_001153669.1
cow (Bos taurus)	PPARG¹	--	peroxisome proliferator-activated receptor gamma	91.02(n) 95.84(a)	281993 NM_181024.2 NP_851367.1
rat (Rattus norvegicus)	Pparg¹	--	peroxisome proliferator-activated receptor gamma	89.83(n) 95.84(a)	25664 NM_013124.1 NP_037256.1
mouse (Mus musculus)	Pparg^{1, 5}	6 (52.70 cM)⁵	peroxisome proliferator activated receptor gamma^{1, 5}	90.03(n)¹ 96.04(a)¹	19016¹ NM_011146.2¹ NP_035276.1¹ AB256529⁵ AB256530⁵ (see all 32)

About this table Species with no ortholog for PPARG

ENSEMBL Gene Tree for PPARG

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for PPARG gene

VDR² PPARD² NR1I2² RARG² PPARA² THRB² RARA² NR1H4²

RARB² NR1D2² RORA² RORB² RORC² NR1D1² NR1I3² NR1H2²

THRA² NR1H3²

PPARG for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231

Polymorphism: Genetic variation in PPARG may influence body mass index (BMI) [MIM:606641]. BMI reflects the amount of

fat, lean mass, and body build

10/720 NCBI SNPs in PPARG are shown (see all 720 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 341)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Related Data				Allele Frequencies
				--	--	--		--	--			--
	rs2197423^1,2	C,F,A,H	12324939(-)	`AGACAC/TGATGG`	4	--	int¹ ng5¹		8	NS EA NA	486
	rs12486170^1,2	C,F,A,H	12325652(+)	`GTTCAA/GACATC`	4	--	int¹ ng5¹		3	NA WA	124
	rs6802898^1,2	C,F,A,H	12324563(+)	`GTTTTC/TGCTTT`	4	--	int¹ ng5¹		11	NS EA NA WA	688
	rs7647481^1,2	C,F,A,H	12325169(+)	`ATTCCG/ATGATG`	4	--	int¹ ng5¹		9	NS EA NA WA	548
--	rs4135364^1,2	C,F,H	12409241(+)	`TCTCCC/TCTCCC`	4	--	ng3¹		11	NS MN NA	732
	rs7649970^1,2	C,F	12325628(+)	`CTTATC/TGTTTA`	4	--	int¹ ng5¹		6	NS EA NA WA	532
--	rs13076933^1,2	C,F	12261094(+)	`tgaacT/Ggtaca`	2	--	ng5¹		6	NS NA EA	230
	rs17036160^1,2	C,F	12263457(+)	`GGGGTC/TTTGGG`	3	--	int¹ ng5¹		5	NS NA	168
--	rs4135300^1,2	C,F	12409308(+)	`TTTTTC/TTTTTC`	4	--	ng3¹		14	NS MN NA EA	1834
--	rs17029002^1,2	C,F	12262595(+)	`AGGGAC/TCCGAA`	3	--	ng5¹		3	NS NA	134

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HapMap Linkage Disequilibrium images for PPARG (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PPARG
2 Indels: 42164 62033
1 Inversion: 37239

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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PPARG for disorders About GeneDecksing

OMIM: 601487

UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231

Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension

Defects in PPARG may be associated with susceptibility to obesity [MIM:601665]

Defects in PPARG may be associated with colon cancer

Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:604367]. Familial partial

lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous

(sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes

mellitus and dyslipidemia

Variation in PPARG is associated with carotid intimal medial thickness 1 (CIMT1) [MIM:609338]. CIMT is a

measure of atherosclerosis that is independently associated with traditional atherosclerotic cardiovascular disease

risk factors and coronary atherosclerotic burden. 35 to 45% of the variability in multivariable-adjusted CIMT is

explained by genetic factors

10/765 Novoseek disease relationships for PPARG gene (see all 765 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
diabetes; type 2	100.00	543	15782399 (5), 15558556 (5), 14514601 (5), 14501167 (5) (see all 100)
insulin resistance	100.00	448	16305809 (5), 11872365 (5), 11533050 (5), 19966034 (4) (see all 100)
insulin sensitivity	100.00	353	20182551 (4), 14536066 (4), 19390629 (3), 17618105 (3) (see all 100)
colon cancer	39.47	213	14521714 (6), 9734398 (4), 9472692 (4), 19458067 (4) (see all 100)
follicular carcinoma	26.04	51	15362967 (6), 12651598 (5), 12170088 (4), 12161538 (4) (see all 26)
familial partial lipodystrophies	25.86	21	17766367 (3), 17312272 (2), 17299075 (2), 16241930 (2) (see all 14)
partial lipodystrophy	23.99	24	18076675 (5), 17356052 (4), 15711581 (3), 19749155 (2) (see all 13)
fpld3	23.32	11	15711581 (3), 17299075 (2), 16412238 (2), 19748282 (1) (see all 7)
fluid retention	22.83	33	19752200 (2), 19595686 (2), 16822823 (2), 15956187 (2) (see all 28)
inflammatory response	18.87	142	16386242 (3), 16127449 (3), 15470065 (3), 12456800 (3) (see all 100)

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3 PharmGKB disease relationships for PPARG gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Diabetes Mellitus, Non-Insulin-Dependent	PD	15181049
Endometrial Neoplasms	CO GN	15608564
Obesity	PD	9806549

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Genatlas disease: PPARG

marked obesity with a high body-mass index and a defect in the regulation of adipocyte differentiation associated with

type 2 diabetes

Human Gene Mutation Database: PPARG
Genetic Association Database: PPARG
Human Genome Epidemiology Navigator: PPARG (504 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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100/3743 PubMed articles for PPARG gene (see all 3743 ):

No evidence of a role for PPARgamma Pro12Ala polymorphism in endometrial cancer susceptibility. (PubMed id 15608564)^{1, 3, 7} Paynter R.A....De Vivo I. (2004)
Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis. (PubMed id 15356014)^{3, 4, 6} Temelkova-Kurktschiev T....Laakso M. (2004)
PPARgamma gene polymorphism is associated with exercise-mediated changes of insulin resistance in healthy men. (PubMed id 12601634)^{1, 3, 6} Kahara T....Kobayashi K. (2003)
Analysis of the relationship between the Pro12Ala variant in the PPAR-gamma2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes. (PubMed id 12610044)^{1, 3, 6} Bluher M....Paschke R. (2003)
Association between the P12A and c1431t polymorphisms in the peroxisome proliferator activated receptor gamma (PPAR gamma) gene and type 2 diabetes. (PubMed id 11409297)^{1, 3, 6} Evans D....Mann W.A. (2001)
Association between peroxisome proliferator-activated receptor gamma haplotypes and the metabolic syndrome in French men and women. (PubMed id 16186413)^{1, 3, 6} Meirhaeghe A....Dallongeville J. (2005)
Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level? (PubMed id 14681835)^{1, 3, 6} Franks P.W....Wareham N.J. (2004)
Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction. (PubMed id 12663371)^{1, 3, 6} Ridker P.M....Zee R.Y. (2003)
Two polymorphisms in the peroxisome proliferator-activated receptor- gamma gene are associated with severe overweight among obese women. (PubMed id 10523018)^{1, 4, 6} Valve R.... Laakso M. (1999)
Loss-of-function mutations in PPAR-gamma associated with human colon cancer. (PubMed id 10394368)^{1, 3, 4} Sarraf P.... Eng C. (1999)
Additive effects of the PPARgamma, APOE, and FABP-2 genes in increasing daylong triglycerides of normolipidemic women to concentrations comparable to those in men. (PubMed id 15764642)^{1, 3, 6} Ribalta J....Cabezas M.C. (2005)
Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-gamma coactivator-1 gene might be a risk factor for diabetic retinopathy in Slovene population (Caucasians) with type 2 diabetes and the Pro12Ala polymorphism of the PPARgamma gene is not. (PubMed id 15782399)^{1, 3, 6} Petrovic M.G....Petrovic D. (2005)
[Is obesity associated with a polymorphism Pro12Ala and Pro115Gln in the PPARgamma gene?] (PubMed id 15690702)^{1, 3, 6} Bidzinska B....Milewicz A. (2004)
Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma. (PubMed id 9813012)^{1, 3, 4} Uppenberg J....Berkenstam A. (1998)
Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities. (PubMed id 16640330)^{1, 3, 4} Lu I.-L.... Wu S.-Y. (2006)
No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARdelta and PPARgamma act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma. (PubMed id 16141797)^{1, 3, 6} McGreavey L.E....Barrett J.H. (2005)
Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetes. (PubMed id 14514601)^{1, 3, 6} Memisoglu A....Manson J.E. (2003)
Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. (PubMed id 10882139)^{1, 3, 4} Gampe R.T. Jr.... Xu H.E. (2000)
Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists. (PubMed id 9065481)^{1, 3, 4} Mukherjee R.... Paterniti J.R. Jr. (1997)
IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes? (PubMed id 16367885)^{3, 6} Johansen A....Pedersen O. (2006)
Improved prediction of early-onset coronary artery disease using APOE epsilon4, BChE-K, PPARgamma2 Pro12 and ENOS T-786C in a polygenic model. (PubMed id 16298355)^{3, 6} Nassar B.A....Title L.M. (2006)
Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men. (PubMed id 15781195)^{3, 6} Mousavinasab F....Laakso M. (2005)
[Is obesity associated with a polymorphism Pro12Ala and Pro115Gln in PPARgamma gene?] (PubMed id 15518421)^{3, 6} Bidzinska B....Milewicz A. (2004)
Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphisms. (PubMed id 14574455)^{3, 6} Baratta R....Trischitta V. (2003)
The Pro12Ala polymorphism of PPARgamma2 gene and susceptibility to type 2 diabetes mellitus in a Polish population. (PubMed id 14581147)^{3, 6} Malecki M.T....Sieradzki J. (2003)
Combined effects of PPARgamma2 P12A and PPARalpha L162V polymorphisms on glucose and insulin homeostasis: the Quebec Family Study. (PubMed id 14677049)^{3, 6} Bosse Y....Vohl M.C. (2003)
The human peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism is associated with decreased risk of diabetic nephropathy in patients with type 2 diabetes. (PubMed id 14633865)^{3, 6} Caramori M.L....Gross J.L. (2003)
Is a Pro12Ala polymorphism of the PPARgamma2 gene related to obesity and type 2 diabetes mellitus in the Czech population? (PubMed id 12079854)^{3, 6} Sramkova D....Bendlova B. (2002)
Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight. (PubMed id 12429071)^{3, 6} Doney A....Palmer C.N. (2002)
Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) is associated with higher levels of total cholesterol and LDL-cholesterol in male caucasian type 2 diabetes patients. (PubMed id 11928067)^{3, 6} Zietz B....Schaffler A. (2002)
A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. (PubMed id 9806549)^{4, 7} Deeb S.S.... Auwerx J. (1998)
Involvement of PPARgamma in oxidative stress-mediated prostaglandin E(2) production in SZ95 human sebaceous gland cells. (PubMed id 16417216)^{1, 3} Zhang Q....Konger R.L. (2006)
Attenuation of peroxisome proliferator-activated receptor gamma (PPARgamma) mediates gastrin-stimulated colorectal cancer cell proliferation. (PubMed id 16574647)^{1, 3} Chang A.J....Wolfe M.M. (2006)
Colorectal cancer expression of peroxisome proliferator-activated receptor gamma (PPARG, PPARgamma) is associated with good prognosis. (PubMed id 19186181)^{1, 3} Ogino S....Fuchs C.S. (2009)
Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth. (PubMed id 12714563)^{1, 3} Ameshima S....Voelkel N.F. (2003)
Casein-kinase-II-dependent phosphorylation of PPARgam ma provokes CRM1-mediated shuttling of PPARgamma from the nucleus to the cytoso l. (PubMed id 20026644)^{1, 3} von Knethen A....BrA1ne B. (year=2010;month=Jan;day=15)
Th1 cytokine-induced downregulation of PPARgamma in human biliary cells relates to cholangitis in primary biliary cirrhosis. (PubMed id 15880426)^{1, 3} Harada K....Nakanuma Y. (2005)
Disruption of ERalpha signalling pathway by PPARgamma agonists: evidences of PPARgamma-independent events in two hormone-dependent breast cancer cell lines. (PubMed id 18204896)^{1, 3} Lecomte J....Grillier-Vuissoz I. (2008)
Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPARgamma) gene in inflammatory bowel disease. (PubMed id 19104705)^{1, 3} Atug O....Tozun N. (2008)
Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor (TCF) pathway. (PubMed id 18391483)^{1, 3} Fujisawa T....Blumberg R.S. (2008)
Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. (PubMed id 16407166)^{1, 3} Sastre M....Heneka M.T. (2006)
Phorbol ester potentiates the growth inhibitory effects of troglitazone via up-regulation of PPARgamma in A549 cells. (PubMed id 16945329)^{1, 3} Kim H.J....Seo H.G. (2006)
Depressed peroxisome proliferator-activated receptor gamma (PPargamma) is indicative of severe pulmonary sarcoidosis: possible involvement of interferon gamma (IFN-gamma). (PubMed id 17937104)^{1, 3} Barna B.P....Thomassen M.J. (2006)
The localisation and reduction of nuclear staining of PPARgamma and PGC-1 in human breast cancer. (PubMed id 15254719)^{1, 3} Watkins G....Jiang W.G. (2004)
PPARgamma and Wnt/beta-Catenin pathway in human breas t cancer: expression pattern, molecular interaction and clinical/prognostic cor relations. (PubMed id 19495794)^{1, 3} Jiang Y....Shen A. (year=2009;month=Nov;day=)
New recurrent deletions in the PPARgamma and TP53 genes are associated with childhood myelodysplastic syndrome. (PubMed id 18789822)^{1, 3} Silveira C.G....Rogatto S.R. (2009)
The role of PPARgamma in high-fat diet-induced obesity and insulin resistance. (PubMed id 11872365)^{1, 3} Kadowaki T....Akanuma Y. (2002)
PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons. (PubMed id 19383491)^{1, 3} Du J....Wang Z. (2009)
An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. (PubMed id 18382765)^{1, 3} Hansmann G....Rabinovitch M. (2008)
Down-regulation of PPARgamma1 suppresses cell growth and induces apoptosis in MCF-7 breast cancer cells. (PubMed id 19061500)^{1, 3} Zaytseva Y.Y....Kilgore M.W. (2008)
Energy balance and food intake: the role of PPARgamma gene polymorphisms. (PubMed id 16777151)^{1, 3} Cecil J.E....Hetherington M. (2006)
Immunohistochemical detection of PPARgamma receptors in the human pituitary adenomas: correlation with PCNA. (PubMed id 16201313)^{1, 3} Winczyk K. and Pawlikowski M. (2005)
Expression of peroxisome-proliferator activated receptor-gamma (PPARgamma) and the PPARgamma co-activator, PGC-1, in human breast cancer correlates with clinical outcomes. (PubMed id 12866036)^{1, 3} Jiang W.G....Mansel R.E. (2003)
Differential effects of PPARgamma activation by the o ral antidiabetic agent pioglitazone in Barrett's carcinoma in vitro and in vivo . (PubMed id 19506796)^{1, 3} Al-Taie O.H....Seufert J. (year=2009;month=;day=)
Downregulation of GATA-2 and overexpression of adipog enic gene-PPARgamma in mesenchymal stem cells from patients with aplastic anemi a. (PubMed id 19772889)^{1, 3} Xu Y....Kojima S. (2009)
Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands. (PubMed id 19101554)^{1, 3} Waku T....Morikawa K. (2009)
The Role of PPARgamma in pulmonary vascular disease. (PubMed id 18317434)^{1, 3} Hart C.M. (2008)
A novel selective peroxisome proliferator-activator receptor-gamma modulator-SPPARgammaM5 improves insulin sensitivity with diminished adverse cardiovascular effects. (PubMed id 18346728)^{1, 3} Chang C.H....McCann M.E. (2008)
Modulation of cell growth and PPARgamma expression in human colorectal cancer cell lines by ciglitazone. (PubMed id 18579355)^{1, 3} Yaacob N.S....Norazmi M.N. (2008)
Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C/EBP. (PubMed id 17785586)^{1, 3} Wang L.H....Farrar W.L. (2007)
Peroxisome proliferator-activated receptor gamma (PPARgamma) regulates trefoil factor family 2 (TFF2) expression in gastric epithelial cells. (PubMed id 17118693)^{1, 3} Shimada T....Hiraishi H. (2007)
Both PPARgamma and PPARdelta influence sulindac sulfide-mediated p21WAF1/CIP1 upregulation in a human prostate epithelial cell line. (PubMed id 16091736)^{1, 3} Jarvis M.C....Palmer C.N. (2005)
Association of Pro12Ala polymorphism of PPARgamma gene with insulin resistance and related diseases. (PubMed id 15563983)^{1, 3} Horiki M....Ogihara T. (2004)
Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-kappabeta. (PubMed id 14587029)^{1, 3} Chen F....Harrison L.E. (2003)
Activation-induced PPARgamma expression sensitizes primary human T cells toward apoptosis. (PubMed id 12714582)^{1, 3} Tautenhahn A....von Knethen A. (2003)
PPARgamma activation enhances cell surface ENaCalpha via up-regulation of SGK1 in human collecting duct cells. (PubMed id 12923071)^{1, 3} Hong G....Brown J. (2003)
Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric cancer patients. (PubMed id 14627349)^{1, 3} Konturek P.C....Hahn E.G. (2003)
Insulin resistance is attenuated in women with polycystic ovary syndrome with the Pro(12)Ala polymorphism in the PPARgamma gene. (PubMed id 11836319)^{1, 3} Hara M....Ehrmann D.A. (2002)
PPARgamma expression in normal human placenta, hydatidiform mole and choriocarcinoma. (PubMed id 12029076)^{1, 3} Capparuccia L....Castellucci M. (2002)
The role of PPARgamma as a thrifty gene both in mice and humans. (PubMed id 11242476)^{1, 3} Hara K....Kadowaki T. (2000)
Telmisartan induces proliferation of human endothelia l progenitor cells via PPARgamma-dependent PI3K/Akt pathway. (PubMed id 19193378)^{1, 3} Honda A....Hagiwara N. (year=2009;month=Aug;day=)
Repression of NHE1 expression by PPARgamma activation is a potential new approach for specific inhibition of the growth of tumor cel ls in vitro and in vivo. (PubMed id 19887620)^{1, 3} Kumar A.P....ClAcment M.V. (2009)
Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia. (PubMed id 19052558)^{1, 3} Karnik P....Mirmirani P. (2009)
Formation of STAT5/PPARgamma transcriptional complex modulates angiogenic cell bioavailability in diabetes. (PubMed id 18927468)^{1, 3} Dentelli P....Brizzi M.F. (2009)
The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose uptake during hyperinsulinemia in subjects with type 2 diabetes mellitus. (PubMed id 19303976)^{1, 3} Honka M.J....Laakso M. (2009)
FOXA1 and IRF-1 intermediary transcriptional regulators of PPARgamma-induced urothelial cytodifferentiation. (PubMed id 18688264)^{1, 3} Varley C.L....Southgate J. (2009)
Association and interaction analyses of genetic varia nts in ADIPOQ, ENPP1, GHSR, PPARgamma and TCF7L2 genes for diabetic nephropathy in a Taiwanese population with type 2 diabetes. (PubMed id 19506043)^{1, 3} Wu L.S....Lin E. (2009)
Association between two common polymorphisms of PPARgamma gene and metabolic syndrome families in a Chinese population. (PubMed id 19237017)^{1, 3} Yang L.L....Yang Z. (2009)
Alanine variant of the Pro12Ala polymorphism of the PPARgamma gene might be associated with decreased risk of diabetic retinopathy in type 2 diabetes. (PubMed id 18077048)^{1, 3} Malecki M.T....Sieradzki J. (2008)
Fatty acid metabolism in patients with PPARgamma mutations. (PubMed id 18713822)^{1, 3} Tan G.D....Karpe F. (2008)
Effect of heterodimer partner RXRalpha on PPARgamma activation function-2 helix in solution. (PubMed id 17980149)^{1, 3} Lu J....Li E. (2008)
The PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population. (PubMed id 19178525)^{1, 3} Osawa H....Kohara K. (2008)
PPARgamma mRNA expression is reduced in peripheral blood mononuclear cells after fat overload in patients with metabolic syndrome. (PubMed id 18424599)^{1, 3} Macias-Gonzalez M....Tinahones F.J. (2008)
n-3 and n-6 polyunsaturated fatty acids induce the expression of COX-2 via PPARgamma activation in human keratinocyte HaCaT cells. (PubMed id 17459764)^{1, 3} Chene G....Pipy B. (2007)
Increased expression of transglutaminase-1 and PPARgamma after vitamin E treatment in human keratinocytes. (PubMed id 16530159)^{1, 3} De Pascale M.C....Zingg J.M. (2006)
PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States). (PubMed id 16489531)^{1, 3} Slattery M.L....Samowitz W. (2006)
Patterns of association between PPARgamma genetic variation and indices of adiposity and insulin action in African-Americans and whites: the CARDIA Study. (PubMed id 16955276)^{1, 3} Wei Q....Fornage M. (2006)
Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARgamma gene and colorectal cancer risk in Japanese. (PubMed id 16965392)^{1, 3} Kuriki K....Tajima K. (2006)
Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance. (PubMed id 17011503)^{1, 3} Agostini M....Chatterjee K. (2006)
[Influence of polymorphism pro12Ala of PPARgamma gene on endothelium destruction in patients with diabetes mellitus t. 2] (PubMed id 16789503)^{1, 3} Gacka M....Adamiec R. (2005)
PPARgamma, energy balance, and associations with colon and rectal cancer. (PubMed id 15860437)^{1, 3} Slattery M.L....Samowitz W. (2005)
Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both? (PubMed id 12502512)^{1, 3} Poulsen P....Vaag A. (2003)
Gene-gene interaction of PPARgamma and ApoE affects coronary heart disease risk. (PubMed id 14659862)^{1, 3} Peng D.Q....Li J. (2003)
Effect of the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene on the expression of PPARgamma target genes in adipose tissue of massively obese subjects. (PubMed id 12679463)^{1, 3} Kolehmainen M....Vidal H. (2003)
Variants in the PPARgamma gene affect fatty acid and glycerol metabolism in familial combined hyperlipidemia. (PubMed id 14680975)^{1, 3} Eurlings P.M....de Bruin T.W. (2003)
Activation of PPARgamma increases PTEN expression in pancreatic cancer cells. (PubMed id 12535639)^{1, 3} Farrow B. and Evers B.M. (2003)
GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. (PubMed id 12615657)^{1, 3} Abe M....Kita T. (2003)
Ligands for PPARgamma and RAR cause induction of growth inhibition and apoptosis in human glioblastomas. (PubMed id 14686729)^{1, 3} Zang C....Elstner E. (2003)
The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. (PubMed id 12479814)^{1, 3} Fajas L....Auwerx J. (2002)
HMG-CoA reductase inhibitors (statins) activate expre ssion of PPARalpha/PPARgamma and ABCA1 in cultured gallbladder epithelial cells . (PubMed id 19225884)^{1, 3} Lee J....Choi H.S. (year=2010;month=Feb;day=)

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Entrez Gene: 5468	HGNC: 9236	AceView: PPARG	Ensembl:ENSG00000132170	euGenes: HUgn5468
ECgene: PPARG	Kegg: 5468	H-InvDB: PPARG

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for PPARG	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PPARG
SeattleSNPs	http://pga.gs.washington.edu/data/pparg/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=PPARG

Intellectual Property for PPARG gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for PPARG gene:

Search GeneIP for patents involving PPARG

Licensable Technologies for PPARG gene:

Salk Institute:

Use of RAR Antagonists as Modulators of Hormone Mediated Processes

(see all 4)

GeneCards and IP:

Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PPARG:

TaqMan ® Gene Expression Assays

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GeneCards Homepage - Last full update: 21 May 2010 - Incremental updates: 24 May 2010 , 20 Jun 2010

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Category			ACSF3 acyl-CoA synthetase family member 3
GIFtS Group

The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

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PPARG gene at Home site.

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PPARG Gene

protein-coding GIFtS: 73

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breast mouse
malformation
salivary gland carcinoma
lung tumor
fibrosis myocardial
relapse
h pylori infection
epilepsies
thymoma
cystic fibrosis
actinic keratosis
direct infection
atherosclerosis
nonsense mutation
nasal polyp
colorectal adenocarcinoma
hypoglycemia
neuroblastoma
apoa1
bone inflammation
diabetes mellitus insulin-dependent
volume overload
failure heart
uveitis
age-related macular degeneration
pulmonary capillary hemangiomatosis
lymphoma
gastric mucosal lesion
cardiovascular cancer
pancreatitis
host-tumor interaction
pparg2, pro12ala
childhood obesity
intestinal metaplasia
cognitive impairment
atopic
diabetic complication
hypertension malignant
androgen independent prostate cancer
plaque psoriasis
congenital heart defect
cancer induction
abdominal aortic aneurysm
sclerosis; systemic
ovarian serous carcinoma
metabolic syndrome
arthritis, collagen-induced
leukostasis
hypertension systolic
metastasis
degenerative
adenocarcinoma endometrial
necrosis
acidosis
tangier disease
central nervous system inflammation
chagas disease
peptic ulcer
glioblastoma multiforme
prostate tumor
testis cancer
chondrosarcoma
graves ophthalmopathy
leukemia; lymphoma
chromosomal rearrangement
alveolar bone loss
intestinal polyposis
common tumor
arteritis
leishmaniasis visceral
lipodystrophy syndrome
cardiac; fibrosis
non-alcoholic steatohepatitis
inflammatory bowel disease 1
acute leukemia
epithelial tumor
b-cell lymphoma
renal fibrosis
osteosarcoma
FCI
osteoporosis
endocrinopathy
hepatic ischemia
lymphopenia
aging; premature
overfed
viremia
carotid artery plaque
dyslipoproteinemia
esophageal adenocarcinoma
pituitary tumor
arthritis psoriatic
hypoplasia
condyloma acuminatum
immune dysfunction
hypertrophy; ventricular; right
cardiovascular degeneration
benign tumor
rhinitis seasonal
chronic gastric ulcer
hyperglycemia stress
hypertensive nephropathy
dilatations
invasive breast cancer
escc
peritonitis
ovarian epithelial tumor
encephalitis
bone disease
papilloma
lupus erythematosus systemic
hepatocarcinogenesis
fatty liver
cns disease
damage liver
brain disease
infertility
growth suppression
bronchial hyperresponsiveness
inflammatory disease
adenocarcinoma lung
insulin sensitivity
autoimmune disease
barrett epithelium
breast cancer
eczema
infarction; myocardial
tendon xanthoma
wolman disease
hypercholesterolemia
pancreatic fibrosis
emphysema
follicular tumor
exophthalmos
carcinoma transitional cell
insufficiency renal
tumor promotion
chromosomal aberration
gout; primary
intestinal ischemia
perennial allergic rhinitis
effusion
hemorrhage intracerebral
nonfunctioning pituitary adenoma
chlamydia pneumoniae infection
post-ercp acute pancreatitis
healing ulcer
CHF
intraepithelial carcinoma
hyperglycemia
cervical cancer
anemia
cancer other
mdm2 gene amplification
morbid obesities
multiple symmetric lipomatosis
lipodystrophies
prostatic adenocarcinoma
conduction; delay
CLL
pulmonary alveolar proteinosis
hepatoblastoma
breast cancer metastatic
steatosis
renal angiomyolipoma
dlbcl
colitis
ataxia; friedreich
cmd1s
oedema peripheral
mucosal inflammation
medulloblastoma
glioma
rotator cuff tear
acute myeloid leukemia
carcinoma; renal cell
gastrointestinal candidiasis
chronic allograft nephropathy
cholangioma
genetic syndrome
fpld3
disorder; metabolic
liposarcoma; myxoid
cardiovascular morbidity
acanthosis nigricans
ovary; polycystic (syndrome)
follicular carcinoma
diabetic macroangiopathy
neuropathogenesis
enzyme inhibition
insulin resistance
sodium retention
PKU
aneurysm aortic
familial hypercholesterolemia
cushing disease
familial partial lipodystrophies
refractory tumor
tsh-oma
granulomatosis; wegener
biliary tract cancer
leukemia myeloid
null cell adenoma
granuloma
hyperplastic nodule
liposarcoma; pleomorphic
glomerulonephritis
von willebrand
undifferentiated sarcoma
endometrial cancer
delivery preterm
microalbuminuria
glucose tolerance impaired
agenesis
pancreatic ductal adenocarcinoma
dysplasia
dysfunction; placental
tumor growth
retroperitoneal sarcoma
aortic aneurysm, familial thoracic
salivary gland tumor
acne
hyperthyroidism
edema
ureteral obstruction
gastrointestinal cancer
cancer
abdominal obesity
hypertension pulmonary
lipoatrophy
cutaneous melanoma
diabetic microangiopathies
falciparum malaria
growth arrest
nevi
therapy-related myelodysplastic syndrome
cell transformation
vascular tumor
cholangitis chronic
osteonecrosis
alcoholic fatty liver
precancerous lesions
colorectal adenoma
gastrointestinal infection
brain tumor
multiple endocrine neoplasia type 1
hypertrophy; ventricular
prostate cancer recurrent
chronic gastritis
pheochromocytoma
ischemia; mesenteric
papillary carcinoma
poorly differentiated thyroid carcinoma
hashimoto thyroiditis
fibrosarcoma
celiac disease
ileitis
malignant glioma
HI
lipoma
response, acute phase
skin tumor
alopecia scarring
hyperplasia
airway disease
atherosclerotic plaque
insulin resistant diabetes mellitus
renal interstitial fibrosis
RA
infarct
bcg infection
septic shock
xeroderma pigmentosum group d
col2a1
leukemia
pathogeneses
hydatidiform mole
leukemia; monoblastic
hypersensitivity response
carotid artery disease
nasal mucosal inflammation
arteriosclerosis
cognitive deficit
pancreatic ductal carcinoma
myoglobinuric acute renal failure
pancreatic cancer
hematologic malignancies
gastric ulcer
diabetic complications renal
barrett adenocarcinoma
chronic renal failure
pad mass
eosinophilia
acth hypersecretion
enterocolitis
disease graves
ischemic stroke
xenograft model
angiomyolipoma
CAD
autoimmune
atopic dermatitis
cardiomyopathies
hutchinson-gilford progeria syndrome
anemia aplastic
neurological disease other
benign nevi
hyperinflation
fat hypertrophy
inflammatory response
fistula
tumor angiogenesis
squamous cell tumor
articular cartilage; degeneration
multiple organ dysfunction syndrome
microsatellite instability
hyperinsulinemia
retinoblastoma
adult t-cell leukemia
mantle cell lymphoma
essential hypertension
urological cancer
sclerosis
hyperlipidemia
glomerular disease
iugr
melanoma metastatic
autoimmunities
gastric adenoma
diabetes; type 2
ischemia
pulmonary arterial hypertension
carcinoma poorly differentiated
schizophrenia
asthma
fracture; osteoporotic
allergic rhinitis
papilloma skin
adenocarcinoma gastric
cardiovascular risk factor
neurological disorder
scleroderma
familial cold autoinflammatory syndrome
deficiency; zinc
alcoholic cirrhosis
idiopathic interstitial pneumonia
malnutrition
glomerulosclerosis
proteinuria
chemical carcinogenesis
immunodeficiency
pulmonary langerhans cell histiocytosis
hepatitis b
pre-diabetic
leukemia monocytic
congenital generalized lipodystrophies
soft tissue tumor
impaired insulin secretion
bleeding rectal
sarcoma
hypersensitivities
disease; ischemic heart
carotid atherosclerosis
dwarf
recurrent tumor
alcohol; liver
hyponatremia
encephalomyelitis
lesion; skin
adrenocortical tumor
dermatitis
mammary adenocarcinoma
chronic inflammatory disease
urolithiasis
partial lipodystrophy
prolactinoma
bacterial infection
fatty acid; metabolic disorder
liposarcoma
acromegaly
colorectal polyp
neurodegeneration
well differentiated liposarcoma
nephrosclerosis
calcification
carcinoid
chronic hepatitis c
breast adenocarcinoma metastatic
dedifferentiated liposarcoma
ALS
acute inflammatory response
CKD
colonic polyp
mitochondrial damage
heart; ischemic
retinopathies
complications; vascular
tumorigenicity
skin cancer
AD
pathological angiogenesis
restenosis
cardiac hypertrophy
lichen planopilaris
leukemia lymphoid
stroke
infectious
liver metastases
FCHL
cholangiohepatitis
syndrome x
ovarian tumor
atrophy muscle
adenomyosis
renal tumor
synovial sarcoma
breast liposarcoma
benign ovarian tumor
germline mutation
tumor morphology
hepatic insufficiency
aneuploid
indolence
bronchioloalveolar carcinoma
neurodegenerative disease
interstitial nephritis
alcoholic cardiomyopathy
COPD
allergic asthma
cardiac defect
hypertrophy; ventricular; left
hurthle cell neoplasm
gene fusion
malignant disease
disease; liver
brain infarction
acute ulcerative colitis
ovarian cancer
cirrhosis (liver)
epithelial proliferation
leiomyoma
large cell carcinoma
thrombus
atherogenesis
childhood myelodysplastic syndrome
osteoporosis postmenopausal
late onset alzheimer disease
fibrosis liver
diabetic macular retinopathy
insulinoma
psoriasis
sclc
immunosuppression
neuritis optic
aortic stenosis
contact hypersensitivities
colorectal cancer metastatic
adenomatous polyposis coli
cell injury
lymphoma, t-cell
lymph node metastasis
hepatitis c
hyperandrogenism
chronic disease
infection induced
diabetic vascular complication
disease; eye
colon cancer
twinning, dizygotic
candidiasis
middle cerebral artery occlusion
atrial fibrillation
DSCR1
astrocytoma
thyroid cancer
abscess; brain
PBC
inflammation, allergic
abortion (spontaneous)
extraskeletal myxoid chondrosarcoma
acute lymphoblastic leukemia
mitral regurgitation
hepatotoxicity
clear cell sarcoma
adrenocortical carcinoma
neuropathy
hyperphagia
undifferentiated carcinoma
cholangiocarcinoma
chronic superficial gastritis
senile plaque
gastritis
lymphoma (non-hodgkins)
autoimmune myocarditis
fluid retention
chorioamnionitis
multiple myeloma
class ii; histocompatibility complex
cerebrovascular disease
chronic lung disease
leukemogenesis
vascular disease
cholecystitis
choriocarcinoma
multiple strokes
sepsis
malaria
chronic inflammation
non-small cell carcinoma
erythroleukemia
corticotroph adenoma
postoperative infection
hypertrophic scar
papillary adenoma
intestinal polyp
diabetic retinopathy proliferative
lung cancer
oncogene fusion
myelodysplastic syndrome
SCID
damage; renal
mycosis fungoides
cutaneous t-cell lymphoma
acute infection
lipoma multiple
bone loss
somatic mutation
postoperative ileus
colon adenocarcinoma
shock
cerebral infarction
diabetic cardiomyopathy
age-related bone loss
pneumoniae
colorectal cancer
dominant-negative mutant
pregnancy disorder
choroidal neovascularization
diabetic nephropathies
hypertension
renal impairment
rectal cancer
fatty streaks
diabetic glomerulonephritis
arrhythmia
cysts
oral cancer
colonic disease
chronic respiratory disease
sarcoidosis
tuberous sclerosis complex
diabetes mellitus (gestational)
diastolic dysfunction
vascular inflammations
innate immune response
thrombosis
placental choriocarcinoma
atrophic gastritis
congestive hypertrophy
cardiovascular disease
preeclampsia
colon tumor
huntington disease
gvhd
barrett esophagus
gastric cancer
change; vascular
fungal gastrointestinal infection
melanoma
glaucoma
morphologic alteration
tumor progression
keloids
carnitine; muscle
cardiac event
complications; metabolic
adenocarcinoma differentiated poorly
disease parkinsons
obese
disease; inflammatory bowel
fibrosis pulmonary
human immunodeficiency virus
myocarditis
ventricular dysfunction
acute gout
leydig cell tumor
lung adenoma
metabolic syndrome x
atherosclerotic cardiovascular disease
cebpg
aggressive behavior
gout
arrhythmogenic right ventricular cardiomyopathy
disease; lung
chronic myeloid leukemia
solid tumor
periodontal disease
angina unstable
recurrent carcinoma
oncogene activation
diabetes mellitus risk
effusion pericardial
cerebral ischemia
somatotropinoma
endometrial hyperplasia
chronic obstructive asthma
caruncle
granulosa cell cancer
focal hyperplasia
proliferative retinopathy
hyperthecosis
adenoma thyroid
pulmonary sarcoidosis
endometriosis
colitis ulcerative
macroangiopathy
peritoneal fibrosis
liver mass
conjunctival scarring
nsclc
primary tumor
lesion; vascular
diabetic retinopathies
tumor necrosis
acute gastric mucosal lesion
adenoma; pituitary
demyelinating disease
preterm infant
rsv infection
oncogenesis
acute promyelocytic leukemia
hypertrophic obesity
intraepithelial prostatic neoplasia
brain pathology
polyp
ulcer
acute renal failure
hypolipidemia
MS
enterocolitis necrotizing
cardiomyopathy dilated
carcinoma; hurthle cell
bladder transitional cell carcinoma
endothelial dysfunction
schistosomiasis japonica
focal proliferation
somatotroph adenoma
hypotensive
enterocolitis hemorrhagic
carcinoma papillary thyroid
renal ischemia
cachexia; cancer
carcinogenicity
bile duct carcinoma
failure; renal
gastrointestinal disease
papillary tumor
desmoplastic
cardiovascular complication
disease; respiratory
iga nephropathies
b-all
squamous cell carcinoma
contact sensitivities
diabetes mellitus
nonalcoholic steatohepatitis
insulin lipodystrophy
hypertrophies
cystic fibrosis lung
colorectal tumor
stasis
adenoma
cholangitis
salivary duct carcinoma
squamous metaplasia
fpld2
signet-ring cell carcinoma
nelson syndrome
dcis
malignant transformation
metabolic disturbance
acute coronary syndrome
skin carcinogenesis
animal diseases
oral infection
medial degeneration
mucosal ulcer
gastric tumor
acute myocardial infarction
epilepticus; status
endotoxic shock
SAH
squamous cell carcinoma lung
hypoxic
cellular stress
hemorrhagic shock
insulin-resistant diabetes
cancer cell growth
adenocarcinoma
tumor; wilms
neck cancer
bronchopulmonary dysplasia
brain; ischemic
cns demyelinating disease
coronary atherosclerosis
congenital hyperinsulinism
dyslipidemia
acute pancreatitis
inflammation
embolism
SIRS
hyperhomocysteinemia
vascular calcification
prostate cancer
mammary tumorigenesis
acute colitis
carcinoma hepatocellular
lipid disorder
pancreatic adenocarcinoma
fat; heart
glioblastoma
adjuvant arthritis
disease; skin
marfan syndrome
cd36 deficiency
corneal neovascularization
disease; heart
bladder cancer
lipid deposition
demyelination
cholesteatoma
diseases; multiple
osteoarthritis
ppar-gamma rearrangement
vasospasm
neutrophil migration
breast tumor
bowenoid papulosis
transient cerebral ischemia
nuclear accumulation
goiter
disorder endometrial
chronic lung injuries
diabetic neuropathies
cholesterol depletion
gestational trophoblastic disease
peripheral arterial disease
cardia
anaplastic thyroid carcinoma
nephropathies
vitamin a deficiencies
adrenal tumor
asthma chronic
hematoma
enteropathy
acute itp
esophageal cancer
genetic disorder
embolic stroke
brain degeneration
myocardial reperfusion injuries
arthritis
hypothyroid

Advanced Search (alpha)

PPARG Gene

protein-coding GIFtS: 73

Aliases & Descriptionsfor PPARG gene

Summariesfor PPARG gene

Genomic Viewsfor PPARG gene

Proteinsfor PPARG gene

Protein Domains/Familiesfor PPARG gene

Gene Functionfor PPARG gene

Pathways & Interactionsfor PPARG gene

Drugs & Compoundsfor PPARG gene

Transcriptsfor PPARG gene

Expression for PPARG gene

Orthologsfor PPARG gene

Paralogsfor PPARG gene

Genomic Variantsfor PPARG gene

Disorders & Mutationsfor PPARG gene

Medical Newsfor PPARG gene

Publicationsfor PPARG gene

Search for PPARG gene

Genome Databases showing PPARG gene

Other Databases showing PPARG gene

Specialized Databases showing PPARG gene

Intellectual Propertyfor PPARG gene

Servicesfor PPARG gene

View Random Gene

Aliases &
Descriptions
for PPARG gene

Summaries
for PPARG gene

Genomic Views
for PPARG gene

Proteins
for PPARG gene

Protein Domains/
Families
for PPARG gene

Gene Function
for PPARG gene

Pathways & Interactions
for PPARG gene

Drugs & Compounds
for PPARG gene

Transcripts
for PPARG gene

Expression
for PPARG gene

Orthologs
for PPARG gene

Paralogs
for PPARG gene

Genomic Variants
for PPARG gene

Disorders & Mutations
for PPARG gene

Medical News
for PPARG gene

Publications
for PPARG gene

Intellectual Property
for PPARG gene

Services
for PPARG gene