Aliases for PPARG Gene
- Peroxisome Proliferator Activated Receptor Gamma 2 3
- Peroxisome Proliferator-Activated Receptor Gamma 2 5
- Nuclear Receptor Subfamily 1 Group C Member 3 3 4
- PPAR-Gamma 3 4
- NR1C3 3 4
- Peroxisome Proliferator-Activated Nuclear Receptor Gamma Variant 1 3
- Peroxisome Proliferative Activated Receptor, Gamma 2
External Ids for PPARG Gene
Previous GeneCards Identifiers for PPARG Gene
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPARG Gene
PPARG (Peroxisome Proliferator Activated Receptor Gamma) is a Protein Coding gene. Diseases associated with PPARG include Lipodystrophy, Familial Partial, Type 3 and Obesity. Among its related pathways are Development Ligand-independent activation of ESR1 and ESR2 and Glucose / Energy Metabolism. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is NR1D2.
UniProtKB/Swiss-Prot for PPARG Gene
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression.