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PPARG Gene

protein-coding   GIFtS: 75
GCID: GC03P012328

Peroxisome Proliferator-Activated Receptor Gamma

(Previous names: peroxisome proliferative activated receptor, gamma)
  See PPARG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peroxisome Proliferator-Activated Receptor Gamma1 2     PPARG22 5
Nuclear Receptor Subfamily 1 Group C Member 32 3     Peroxisome Proliferative Activated Receptor, Gamma1
NR1C32 3     PPARgamma2
PPAR-gamma2 3     Peroxisome Proliferator-Activated Nuclear Receptor Gamma Variant 12
CIMT12 5     Peroxisome Proliferator-Activated Receptor Gamma 12
GLM12 5     PPAR Gamma2
PPARG12 5     

External Ids:    HGNC: 92361   Entrez Gene: 54682   Ensembl: ENSG000001321707   OMIM: 6014875   UniProtKB: P372313   

Export aliases for PPARG gene to outside databases

Previous GC identifers: GC03P012258 GC03P012304 GC03P012305 GC03P012263


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PPARG Gene:
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear
receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription
of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded
by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been
implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer.
Alternatively spliced transcript variants that encode different isoforms have been described. (provided by
RefSeq, Jul 2008)

GeneCards Summary for PPARG Gene:
PPARG (peroxisome proliferator-activated receptor gamma) is a protein-coding gene. Diseases associated with PPARG include familial partial lipodystrophy type 3, and obesity, pparg-related. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is VDR.

UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231
Function: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once
activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the
transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation
pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key
regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by
suppressing NF-kappa-B-mediated proinflammatory responses

summary for PPARG Gene:
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear receptor family of
ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate
gene expression. PPARgamma is located primarily in the adipose tissue, lymphoid tissue, colon, liver and
heart and is thought to regulate adipocyte differentiation and glucose homeostasis. PPARgamma has been
implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer.
The human gene encoding PPARgamma has been localized to chromosome 3 (3p25).

Gene Wiki entry for PPARG (Peroxisome proliferator-activated receptor gamma) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPARG gene promoter:
         CREB   deltaCREB   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): PPARG promoter sequence
   Search Chromatin IP Primers for PPARG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPARG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25   Ensembl cytogenetic band:  3p25.2   HGNC cytogenetic band: 3p25

PPARG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPARG gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P012328:  view genomic region     (about GC identifiers)

Start:
12,328,867 bp from pter      End:
12,475,855 bp from pter
Size:
146,989 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231 (See protein sequence)
Recommended Name: Peroxisome proliferator-activated receptor gamma  
Size: 505 amino acids; 57620 Da
Subunit: Heterodimer with other nuclear receptors, such as RXRA. The heterodimer with the retinoic acid receptor
RXRA is called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a
strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase
in transcription of target genes. Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 and
NCOA2 LXXLL motifs. Interacts with ASXL1, ASXL2, DNTTIP2, FAM120B, MAP2K1/MEK1, NR0B2, PDPK1, PRDM16, PRMT2 and
TGFB1I1. Interacts (when activated by agonist) with PPP5C. Interacts with HELZ2 and THRAP3; the interaction
stimulates the transcriptional activity of PPARG
Sequence caution: Sequence=AAN38992.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA23354.1; Type=Erroneous gene model prediction; Sequence=BAF83270.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=CAA62153.1; Type=Erroneous initiation; Note=Translation
N-terminally extended;
Selected PDB 3D structures from and Proteopedia for PPARG (see all 120):
1FM6 (3D)        1FM9 (3D)        1I7I (3D)        1K74 (3D)        1KNU (3D)        1NYX (3D)    
Secondary accessions: A8K3G6 B5BUA1 O00684 O00710 O14515 Q0QJH8 Q15178 Q15179 Q15180 Q15832
Q86U60 Q96J12
Alternative splicing: 3 isoforms:  P37231-1   P37231-2   P37231-3   (Exhibits dominant negative activity over isoform 1)

Explore the universe of human proteins at neXtProt for PPARG: NX_P37231

Explore proteomics data for PPARG at MOPED

Post-translational modifications: 

  • O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes (By similarity)1
  • Phosphorylated in basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by
    PPP5C. The phosphorylated form may be inactive and dephosphorylation at Ser-112 induces adipogenic activity (By
    similarity)1
  • Glycosylation2 at Thr84
  • Modification sites at PhosphoSitePlus

  • See PPARG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_005028.4  NP_056953.2  NP_619725.2  NP_619726.2  

    ENSEMBL proteins: 
     ENSP00000380205   ENSP00000380224   ENSP00000312472   ENSP00000380210   ENSP00000411931  
     ENSP00000380207   ENSP00000380221   ENSP00000392285   ENSP00000380196   ENSP00000287820  
     ENSP00000380218   ENSP00000380195   ENSP00000438940  
    Reactome Protein details: P37231

    PPARG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for PPARG
    OriGene Protein Over-expression Lysate for PPARG
    OriGene MassSpec for PPARG
    OriGene Custom Protein Services for PPARG
    GenScript Custom Purified and Recombinant Proteins Services for PPARG
    Novus Biologicals PPARG Proteins
    Novus Biologicals PPARG Lysates
    Sino Biological Recombinant Protein for PPARG
    Sino Biological Cell Lysate for PPARG
    ProSpec Recombinant Protein for PPARG
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PPARG 

    PPARG Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PPARG
    R&D Systems Antibodies for PPARG (PPAR gamma/NR1C3)
    Cell Signaling Technology (CST) Antibodies for PPARG  (PPAR-gamma)
    OriGene Antibodies for PPARG
    OriGene Custom Antibody Services for PPARG
    Novus Biologicals PPARG Antibodies
    Abcam antibodies for PPARG
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PPARG
    LSBio Antibodies in human, mouse, rat for PPARG

    PPARG Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PPARG
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPARG
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for PPARG 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Peroxisome proliferator-activated receptor-gamma
    1C. Peroxisome proliferator-activated receptors

    Selected InterPro protein domains (see all 8):
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR003077 1Cnucl_rcpt_G
     IPR001723 Str_hrmn_rcpt
     IPR003074 1Cnucl_rcpt
     IPR013088 Znf_NHR/GATA

    Graphical View of Domain Structure for InterPro Entry P37231

    ProtoNet protein and cluster: P37231

    3 Blocks protein domains:
    IPB001723 Steroid hormone receptor signature
    IPB003074 Peroxisome proliferator-activated receptor (1C nuclear receptor) signature
    IPB003077 Peroxisome proliferator-activated receptor gamma signature


    UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231
    Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Find genes that share domains with PPARG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPARG_HUMAN, P37231
    Function: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once
    activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the
    transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation
    pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key
    regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by
    suppressing NF-kappa-B-mediated proinflammatory responses
    Enzyme regulation: PDPK1 activates its transcriptional activity independently of its kinase activity

         Genatlas biochemistry entry for PPARG:
    peroxisome proliferator-activated receptor,steroid/thyroid hormone coactivator receptor
    superfamily,heterodimerizing with RXR*,coactivated by SRCO1,expressed (isoform 1) in the diploid trophoblast
    lineages and required for placental development,expressed at low levels in preadipocytes,induced by CEBPB and
    CEBPD,coexpressed with and coregulated by PPARG,jointly required for full adipocyte differentiation and fat
    deposition with variability influencing plasma leptin levels in obese humans,modulator of insulin sensitivity and
    control of glucose homostasis and blood pressure and activation of antidiabetic effect of
    thiazolidinediones,negative regulator of macrophage activation,inhibiting production of monocyte inflammatory
    cytokines,increasing PAI1 expression in endothelial cells.

         Gene Ontology (GO): Selected molecular function terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001012RNA polymerase II regulatory region DNA binding IEA--
    GO:0003677DNA binding ISS--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ISS--
    GO:0003707steroid hormone receptor activity IEA--
         
    Find genes that share ontologies with PPARG           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 26 alleles(MGI details for Pparg) (see all 23):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  muscle 

    Find genes that share phenotypes with PPARG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PPARG: Ppargtm1.2Mgn Ppargtm1Wwah Ppargtm2Avp Ppargtm1.2Gonz Ppargtm1Uls Ppargtm1.1Mtz
                                                         Ppargtm1Tka

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PPARG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PPARG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPARG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPARG

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  TGACCTTTGCCCCA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPARG:
    hsa-mir-27b-3p (MIRT005023), hsa-mir-20b-5p (MIRT004000), hsa-mir-130a-3p (MIRT005957), hsa-mir-1 (MIRT023678), hsa-mir-130b-3p (MIRT005958), hsa-mir-138-5p (MIRT005489), hsa-mir-215-5p (MIRT024414), hsa-mir-192-5p (MIRT026368)

    Block miRNA regulation of human, mouse, rat PPARG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPARG (see all 26):
    hsa-miR-548j hsa-miR-548i hsa-miR-513a-5p hsa-miR-128 hsa-miR-301a hsa-miR-889 hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidPPARG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PPARG
    Predesigned siRNA for gene silencing in human, mouse, rat PPARG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPARG

    Clone
    Products:
         
    OriGene clones in human, mouse for PPARG (see all 27)
    OriGene ORF clones in mouse, rat for PPARG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PPARG (NM_138712)
    Sino Biological Human cDNA Clone for PPARG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPARG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPARG
    Addgene plasmids for PPARG 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PPARG
    Browse ESI BIO Cell Lines and PureStem Progenitors for PPARG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPARG

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10156) for PPARG 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPARG_HUMAN, P37231: Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a
    MAP2K1/MEK1-dependent manner
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    peroxisome4
    cytosol3
    extracellular3
    mitochondrion3
    cytoskeleton2
    endoplasmic reticulum2
    plasma membrane2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9568716
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol ISS--

    Find genes that share ontologies with PPARG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPARG About   (see all 27)  
    See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    3Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    4Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    5Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66


    Find genes that share SuperPaths with PPARG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PPARG
        TGF-beta Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PPARG
        PPAR Pathway

    1 Cell Signaling Technology (CST) Pathway for PPARG
        Glucose / Energy Metabolism

    1 Tocris Bioscience Pathway for PPARG
        mTOR Pathway

    3 GeneGo (Thomson Reuters) Pathways for PPARG
        Development Beta-adrenergic receptors signaling via cAMP
    Transcription PPAR Pathway
    Immune response Oncostatin M signaling via MAPK in human cells

    Selected BioSystems Pathways for PPARG (see all 9)
        Adipogenesis
    Nuclear Receptors
    SREBP signalling
    Nuclear receptors in lipid metabolism and toxicity
    Energy Metabolism


    3 Reactome Pathways for PPARG
        Transcriptional regulation of white adipocyte differentiation
    Nuclear Receptor transcription pathway
    PPARA activates gene expression

    1 PharmGKB Pathway for PPARG
        Celecoxib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for PPARG) (see all 6):
        PPAR signaling pathway
    Osteoclast differentiation
    Huntington's disease
    Pathways in cancer
    Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPARG (see all 21): 
              Insulin Signaling Pathway in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Adipogenesis in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Telomeres & Telomerase in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PPARG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PPARG (P372311, 2, 3 ENSP000002878204) via UniProtKB, MINT, STRING, and/or I2D (see all 165)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPARGC1AQ9UBK22, 3, ENSP000002648674MINT-7229698 MINT-7229685 I2D: score=2 STRING: ENSP00000264867
    ENSG00000235067P074373, ENSP000004013174I2D: score=1 STRING: ENSP00000401317
    ENSG00000183311P074373I2D: score=1 
    ENSG00000224156P074373I2D: score=1 
    ENSG00000227739P074373I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 64):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001890placenta development ISS--
    GO:0002674negative regulation of acute inflammatory response IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----

    Find genes that share ontologies with PPARG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PPARG
      Browse compounds at ApexBio 

    Compounds for PPARG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GW 9662Selective PPARgamma antagonist[22978-25-2]
    TroglitazoneSelective PPARgamma agonist; antidiabetic agent[97322-87-7]
    GW 1929 hydrochlorideSelective PPARgamma agonist. Orally active[196808-24-9]
    T 0070907Highly potent and selective PPARgamma antagonist[313516-66-4]
    Pioglitazone hydrochlorideSelective PPARgamma agonist; antidiabetic agent[112529-15-4]

    Selected HMDB Compounds for PPARG (see all 43)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Butyric acid1-Butyrate (see all 25)107-92-616927016
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--

    Selected DrugBank Compounds for PPARG (see all 38)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    TelmisartanBIBR 277 (see all 2)144701-48-4targetpartial agonist15868121 17691961 18580862 15617852 19147680 16938288 16154710
    Troglitazone-- 97322-87-7targetagonist10222233 10200320 12475986 10214942 10076568 11752352 10097144
    PioglitazonePioglitazona [INN-Spanish] (see all 5)111025-46-8targetagonist9568680 7768881 11752352 20018750 15356026 8576907
    Rosiglitazone-- 122320-73-4targetagonist10764590 10548525 10475242 10871190 11752352 10707565
    IcosapentEicosapentaenoic acid (see all 4)10417-94-4targetagonist11552681 16702329 17052999 12055328 17610002
    BalsalazideBalsalazida [Spanish] (see all 4)80573-04-2targetagonist16939423 20151072 18077625 19708827
    Mesalazine5-aminosalicylate (see all 4)89-57-6targetagonist16939423 15824083 18544567 18077625
    SulfasalazineSulfasalazin (see all 2)599-79-1targetagonist16939423 15824083 18544567 18077625
    ALEGLITAZAR R-1439 (see all 2)475479-34-6targetagonist20653327 10592235
    (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid-- --target--10592235

    Selected IUPHAR Ligands for PPARG (Peroxisome proliferator-activated receptor-gamma) (see all 40)    About this table
    LigandTypeActionAffinityPubmed IDs
    GW409544
    AgonistFull agonist9.5511698662 15293980
    T0070907
    AntagonistAntagonist911877444
    GW1929
    AgonistFull agonist8.8410389847
    L-796449
    AgonistFull agonist8.710037770
    SB-219994
    AgonistFull agonist8.689454824
    GW7845
    AgonistFull agonist8.439836622 9836620
    LY-510929
    AgonistFull agonist83071214 15115385
    CDDO
    AgonistPartial agonist811043571
    L-783483
    AgonistFull agonist7.8510037770
    L-165461
    AgonistFull agonist7.810037770

    Selected Novoseek inferred chemical compound relationships for PPARG gene (see all 130)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rosiglitazone 96.6 1156 10871190 (6), 18630997 (6), 16425225 (5), 18640979 (5) (see all 99)
    15-deoxy-delta-12,14-prostaglandin j2 96.2 785 12401880 (6), 17643887 (6), 11159824 (5), 16198309 (5) (see all 99)
    troglitazone 95.7 829 10871190 (8), 9709955 (7), 12475986 (6), 16303758 (5) (see all 99)
    gw9662 95.6 391 16696951 (6), 12022867 (6), 18203887 (3), 15533890 (3) (see all 99)
    ciglitazone 95.2 363 12697971 (5), 19288012 (5), 17621259 (4), 14587029 (3) (see all 99)
    pioglitazone 94.7 536 17643887 (5), 12610044 (4), 16210596 (4), 17037742 (4) (see all 99)
    thiazolidinedione 93.9 383 10075686 (6), 14713549 (4), 9832442 (4), 17390024 (3) (see all 99)
    gw 1929 85.8 35 15677767 (2), 11358817 (1), 11597575 (1), 15517883 (1) (see all 21)
    pgj-2 84.8 67 15254749 (7), 14600076 (5), 14971050 (3), 14751245 (2) (see all 28)
    prostaglandin j2 84.3 25 8725145 (1), 11668172 (1), 16842938 (1), 10781090 (1) (see all 20)

    1 PharmGKB related drug/compound annotation for PPARG gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  



    Find genes that share compounds with PPARG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for PPARG gene (4 alternative transcripts): 
    NM_005037.5  NM_015869.4  NM_138711.3  NM_138712.3  

    Unigene Cluster for PPARG:

    Peroxisome proliferator-activated receptor gamma
    Hs.162646  [show with all ESTs]
    Unigene Representative Sequence: AB472042
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397010 ENST00000397029 ENST00000309576(uc003bwr.3 uc003bws.3 uc003bwv.3)
    ENST00000397015 ENST00000455517 ENST00000397012(uc010hdz.1 uc003bwu.3)
    ENST00000397026 ENST00000497594(uc003bwt.1) ENST00000438682 ENST00000397000
    ENST00000477039(uc003bww.1) ENST00000287820(uc003bwx.3) ENST00000397023
    ENST00000396999(uc010hea.1) ENST00000539812
    miRNA
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    Block miRNA regulation of human, mouse, rat PPARG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PPARG (see all 26):
    hsa-miR-548j hsa-miR-548i hsa-miR-513a-5p hsa-miR-128 hsa-miR-301a hsa-miR-889 hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidPPARG 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PPARG
    Predesigned siRNA for gene silencing in human, mouse, rat PPARG
    Clone
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    OriGene clones in human, mouse for PPARG (see all 27)
    OriGene ORF clones in mouse, rat for PPARG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PPARG (NM_138712)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPARG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPARG
    Addgene plasmids for PPARG 
    Primer
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    OriGene qPCR primer pairs and template standards for PPARG
    OriGene qSTAR qPCR primer pairs in human, mouse for PPARG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPARG
      QuantiTect SYBR Green Assays in human, mouse, rat PPARG
      Search QuantiFast Probe-based Assays in human, mouse, rat PPARG
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10156) for PPARG 

    Additional mRNA sequence: 

    AB097931.1 AB107271.1 AB307692.1 AB451337.1 AB451486.1 AB472042.1 AB565476.1 AJ563369.1 
    AJ563370.1 AJ698135.1 AK223528.1 AK290581.1 BC006811.1 BT007281.1 D83233.1 DQ356894.1 
    HQ692866.1 U63415.1 U79012.1 X90563.1 

    11 DOTS entries:

    DT.112942  DT.100791622  DT.100791623  DT.100791631  DT.75152583  DT.120867762  DT.97811244  DT.100791626 
    DT.100791629  DT.120867823  DT.95371767 

    Selected AceView cDNA sequences (see all 116):

    BC006811 U63415 CB133173 BQ012901 NM_138711 NM_005037 BM995901 BQ722874 
    AI355115 CD101663 CR609454 BF811102 AB097931 AL543579 BQ012686 BQ003677 
    BT007281 AI200451 BU626490 CR609113 AI280973 AB107271 BM790089 AI767379 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PPARG (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c
    SP1:                                -     -                 -                                                                                 
    SP2:                    -     -     -     -     -     -     -                                                                                 
    SP3:                                                                                                                                          
    SP4:                                                        -                                                           -                     
    SP5:                    -     -     -     -                 -                                                                                 


    ECgene alternative splicing isoforms for PPARG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PPARG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCTTCACC
    PPARG Expression
    About this image


    PPARG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 41 entries
             Visceral White Adipocytes Visceral White Adipose
             White adipocyte-like cells
             Human Preadipocyte-subcutaneous (HPA-s)   
             omental adipose tissue   
     
     Bone (Muscoskeletal System)    fully expand to see all 15 entries
             Endochondral Preosteoblasts Vertebrae
             Membranous Facial Bones
             Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T)
             HyStem+BMP4-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             Osteochondro Progenitor Cells Branchial Arch 1
             HyStem+BMP4-induced E15 cells
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Sebocytes Sebaceous Gland
     
     Mesenchymal Stem Cells
             Bone Marrow Stromal Cells Pelvic Girdle
             Human Mesenchymal Stem Cell-adipose (HMSC-ad)   
    PPARG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPARG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.162646

    UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231
    Tissue specificity: Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also
    detectable in placenta, lung and ovary

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PPARG (see all 21): 
              Insulin Signaling Pathway in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Adipogenesis in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Telomeres & Telomerase in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for PPARG
    OriGene qSTAR qPCR primer pairs in human, mouse for PPARG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PPARG
    QuantiTect SYBR Green Assays in human, mouse, rat PPARG
    Search QuantiFast Probe-based Assays in human, mouse, rat PPARG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPARG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PPARG gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pparg1 , 5 peroxisome proliferator activated receptor gamma1, 5 90.1(n)1
    96.24(a)1
      6 (53.41 cM)5
    190161  NM_011146.31  NP_035276.21 
     1153612215 
    chicken
    (Gallus gallus)
    Aves PPARG1 peroxisome proliferator-activated receptor gamma 82.25(n)
    92.84(a)
      373928  NM_001001460.1  NP_001001460.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPARG6
    peroxisome proliferator-activated receptor gamma
    85(a)
    1 ↔ 1
    2(158798156-158864884)
    African clawed frog
    (Xenopus laevis)
    Amphibia PPARg2 peroxisome proliferator activated receptor gamma 77.61(n)    BC060474.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pparg1 peroxisome proliferator activated receptor gamma 67.02(n)
    69.34(a)
      557037  NM_131467.1  NP_571542.1 


    ENSEMBL Gene Tree for PPARG (if available)
    TreeFam Gene Tree for PPARG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPARG gene
    VDR2  PPARD2  RARG2  NR1I22  PPARA2  THRB2  RARA2  NR1H42  
    NR1D22  RARB2  RORA2  RORB2  RORC2  NR1D12  NR1I32  NR1H22  
    THRA2  NR1H32  
    Selected SIMAP similar genes for PPARG using alignment to 12 protein entries:     PPARG_HUMAN (see all proteins) (see all similar genes):
    NR1C3    ppar gamma2    PPARD    NR1C2    NR1C1    NR1F3
    NR3C2    RORC    HNF4G    RXRB    VDR    NR6A1
    PPARA    NR1F2    NR1F1    RORB    NR2F1    RXRA

    Find genes that share paralogs with PPARG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    PPARG_HUMAN, P37231: Genetic variation in PPARG may influence body mass index (BMI) [MIM:606641]. BMI reflects the amount
    of fat, lean mass, and body build
    PPARG_HUMAN, P37231: Genetic variations in PPARG influence the carotid intimal medial thickness (CIMT) [MIM:609338]. CIMT
    is a measure of atherosclerosis that is independently associated with traditional atherosclerotic cardiovascular
    disease risk factors and coronary atherosclerotic burden. 35 to 45% of the variability in multivariable-adjusted
    CIMT is explained by genetic factors


    Selected SNPs for PPARG (see all 2979)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18005711,2,,4
    CObesity (OBESITY)4 pathogenic112357881(+) ATCTCC/AACCTT 8 /Q /P mis13Minor allele frequency- A:0.00NA 736
    VAR_0227014
    Lipodystrophy, familial partial, 3 (FPLD3)4--see VAR_0227012 R C mis40--------
    VAR_0227004
    Lipodystrophy, familial partial, 3 (FPLD3)4--see VAR_0227002 F L mis40--------
    rs38568061,2
    C,F,A,Hnon-pathogenic112410703(+) GAACAC/TGTGCA 8 H syn1 ese347Minor allele frequency- T:0.11MN NS EU NA EA CSA WA 12384
    rs18051921,2,,4
    Cpathogenic112356271(+) TCTGGC/GCCACC 8 P A mis18Minor allele frequency- G:0.00MN NA 1132
    rs725513621,2
    Cpathogenic112393453(+) GCTCCA/GTGGAG 8 M V mis10--------
    rs725513631,2
    Cpathogenic112393665(+) CCTTTA/TGGTGA 8 L F mis10--------
    rs725513641,2
    Cpathogenic112410545(+) CAGACC/TGCCCA 8 R C mis10--------
    rs18012821,2,,4
    C,F,Huntested112328161(+) TTGACC/GCAGAA 5 P A int1 mis156Minor allele frequency- G:0.08NS MN EU NA EA 13480
    rs730214851,2
    C,F--12262347(+) ATTTGG/TTGATG 2 -- us2k13Minor allele frequency- T:0.16WA NA EA 358

    HapMap Linkage Disequilibrium report for PPARG (12328867 - 12475855 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PPARG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724933CNV Deletion23290073
    esv2669014CNV Deletion23128226
    dgv850e199CNV Deletion23128226
    dgv810e201CNV Deletion23290073
    esv4138CNV Deletion18987735
    esv2661678CNV Deletion23128226
    esv7808CNV Loss19470904
    nsv3702CNV Loss18451855
    nsv7351OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): PPARG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PPARG
    DNA2.0 Custom Variant and Variant Library Synthesis for PPARG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601487   
    OMIM disorders: 601665  604367  609338  125853  
    UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231
  • Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations
    may be associated with colon cancer
  • Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the
    limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
    Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry
  • Lipodystrophy, familial partial, 3 (FPLD3) [MIM:604367]: A form of lipodystrophy characterized by marked
    loss of subcutaneous fat from the extremities. Facial adipose tissue may be increased, decreased or normal.
    Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Glioma 1 (GLM1) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived
    from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes,
    oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. Note=Disease
    susceptibility may be associated with variations affecting the gene represented in this entry. Polymorphic PPARG
    alleles have been found to be significantly over-represented among a cohort of American patients with sporadic
    glioblastoma multiforme suggesting a possible contribution to disease susceptibility

  • Selected diseases for PPARG (see all 38):    
    About MalaCards
    familial partial lipodystrophy type 3    obesity, pparg-related    diabetes, type 2    retroperitoneal liposarcoma
    diabetes mellitus, noninsulin-dependent, with acanthosis nigricans and hypertension    carotid intimal medial thickness 1    morbid obesity    insulin resistance, severe, digenic
    familial partial lipodystrophy    obesity, autosomal dominant    carotid intimal medial thickness    acdc
    salivary gland cancer    obesity, late-onset    obesity, severe, and type ii diabetes    obesity, variation in
    obesity, early-onset    obesity, association with    obesity, mild, early-onset    atherosclerosis

    9 diseases from the University of Copenhagen DISEASES database for PPARG:
    Diabetes mellitus     Atherosclerosis     Hyperglycemia     Lipodystrophy
    Cancer     Hypertension     Fatty liver disease     Heart disease
    Hyperinsulinism

    Find genes that share disorders with PPARG           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PPARG gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin sensitivity 86.4 343 20182551 (4), 19390629 (3), 15637349 (3), 16920849 (2) (see all 99)
    insulin resistance 86.2 403 16305809 (5), 11533050 (5), 11872365 (5), 16508313 (4) (see all 99)
    obesity 76.9 237 9806316 (4), 12709137 (4), 16716756 (4), 10762291 (3) (see all 99)
    niddm 75.3 147 15558556 (5), 19846173 (3), 16920849 (2), 17884451 (2) (see all 96)
    atherosclerosis 73.2 186 12682906 (3), 11790295 (3), 9636198 (2), 11742860 (2) (see all 99)
    lipodystrophy, familial partial 73.2 26 17766367 (3), 17299075 (2), 17312272 (2), 19748282 (1) (see all 13)
    dyslipidemia 71.3 45 15491498 (3), 15684639 (1), 19636418 (1), 19749155 (1) (see all 33)
    inflammation 71 387 18382616 (5), 18400717 (4), 19828904 (4), 16614990 (3) (see all 99)
    partial lipodystrophy 70.3 21 17356052 (4), 15711581 (3), 12453919 (2), 19749155 (2) (see all 12)
    lipodystrophy 69.1 38 19125203 (3), 19534662 (3), 18954260 (2), 15254581 (2) (see all 21)

    Genatlas disease: PPARG
    marked obesity with a high body-mass index and a defect in the regulation of adipocyte differentiation associated
    with type 2 diabetes

    Genetic Association Database (GAD): PPARG
    Human Genome Epidemiology (HuGE) Navigator: PPARG (615 documents)

    Export disorders for PPARG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPARG gene, integrated from 10 sources (see all 4023):
    (articles sorted by number of sources associating them with PPARG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Effects of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala polymorphism on body fat distribution in female Korean subjects. (PubMed id 15562396)1, 2, 4 Kim K.S.... Yoon Y. (Metabolism 2004)
    2. Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis. (PubMed id 15356014)1, 2, 4 Temelkova-Kurktschiev T....Laakso M. (J. Clin. Endocrinol. Metab. 2004)
    3. Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPARgamma) gene in inflammatory bowel disease. (PubMed id 19104705)1, 4, 9 Atug O....Tozun N. (J Gastrointestin Liver Dis 2008)
    4. A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones. (PubMed id 19147680)1, 7, 9 Tagami T....Naruse M. (Endocrinology 2009)
    5. The role of PPARgamma in high-fat diet-induced obesity and insulin resistance. (PubMed id 11872365)1, 4, 9 Kadowaki T....Akanuma Y. (J. Diabetes Complicat. 2002)
    6. Peroxisome proliferator-activated receptor-gamma polymorphism, body mass and prostate cancer risk: evidence for gene-environment interaction. (PubMed id 16763406)1, 4, 9 Zmuda J.M....Ferrell R.E. (Oncology 2006)
    7. ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity. (PubMed id 16421345)1, 4, 9 TankA^ L.B....Froguel P. (Obes. Res. 2005)
    8. [Clinical genetic determinants of carbohydrate metabolism disturbances in patients with hypertension and excessive weight]. (PubMed id 15940190)1, 4, 9 Kobalava Z.h.D....Moiseev V.S. (Kardiologiia 2005)
    9. PPARgamma gene polymorphism is associated with exercise-mediated changes of insulin resistance in healthy men. (PubMed id 12601634)1, 4, 9 Kahara T....Kobayashi K. (Metab. Clin. Exp. 2003)
    10. Associations for lipoprotein lipase and peroxisome proliferator-activated receptor-gamma gene and coronary artery disease in an Indian population. (PubMed id 20430250)1, 4, 9 AshokKumar M....Emmanuel C. (Arch. Med. Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5468 HGNC: 9236 AceView: PPARG Ensembl:ENSG00000132170 euGenes: HUgn5468
    ECgene: PPARG Kegg: 5468 H-InvDB: PPARG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PPARG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPARG Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=PPARG[genesymbol]
    SeattleSNPshttp://pga.gs.washington.edu/data/pparg/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=PPARG

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PPARG gene:
    Search GeneIP for patents involving PPARG

    Licensable Technologies for PPARG gene:
     Salk Institute: Use of RAR Antagonists as Modulators of Hormone Mediated Processes    (see all 4)
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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