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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PPARG Gene

protein-coding GIFtS: 72
GCID: GC03P012328

peroxisome proliferator-activated receptor gamma

(Previous names: peroxisome proliferative activated receptor, gamma )

Explore 270 diseases affiliated with
PPARG via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Peroxisome Proliferator-Activated Receptor Gamma¹ ²		CIMT1² ⁵
NR1C3¹ ² ³		GLM1² ⁵
PPARG1¹ ² ⁵		Peroxisome Proliferative Activated Receptor, Gamma¹
PPARG2¹ ² ⁵		Peroxisome Proliferator-Activated Nuclear Receptor Gamma Variant 1²
PPARgamma¹ ²		Peroxisome Proliferator-Activated Receptor Gamma 1²
Nuclear Receptor Subfamily 1 Group C Member 3² ³		PPAR Gamma²
PPAR-Gamma¹

External Ids:	HGNC: 9236¹	Entrez Gene: 5468²	Ensembl: ENSG00000132170⁷	OMIM: 601487⁵	UniProtKB: P37231³

Export aliases for PPARG gene to outside databases

Previous GC identifers: GC03P012258 GC03P012304 GC03P012305 GC03P012263

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPARG:

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors.

PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various

genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is

PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the

pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced

transcript variants that encode different isoforms have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231

Function: Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a

ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It

therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation

and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated

proinflammatory responses

summary for PPARG:

Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear receptor family of

ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate

gene expression. PPARgamma is located primarily in the adipose tissue, lymphoid tissue, colon, liver and

heart and is thought to regulate adipocyte differentiation and glucose homeostasis. PPARgamma has been

implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer.

The human gene encoding PPARgamma has been localized to chromosome 3 (3p25).

Gene Wiki entry for PPARG (Peroxisome proliferator-activated receptor gamma)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PPARG gene promoter:
CREB deltaCREB C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): PPARG promoter sequence

Search SABiosciences Chromatin IP Primers for PPARG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPARG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25 Ensembl cytogenetic band: 3p25.2 HGNC cytogenetic band: 3p25

PPARG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPARG gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P012328: view genomic region (about GC identifiers)

Start:	12,328,867 bp from pter	End:	12,475,855 bp from pter
Size:	146,989 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231 (See protein sequence)

Recommended Name: Peroxisome proliferator-activated receptor gamma

Size: 505 amino acids; 57620 Da

Subunit: Forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor ARF6.

Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with

coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with FAM120B and PRDM16 (By

similarity). Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 and NCOA2 LXXLL motifs. Interacts

with ASXL1, ASXL2, DNTTIP2, MAP2K1/MEK1, PDPK1, PRMT2 and TGFB1I1. Interacts (via DNA-binding domain) with HELZ2; the

interaction stimulates the transcriptional activity of PPARG

Subcellular location: Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a

MAP2K1/MEK1-dependent manner

Sequence caution: Sequence=AAN38992.2; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAA23354.1; Type=Erroneous gene model prediction; Sequence=BAF83270.1; Type=Erroneous initiation;

Note=Translation N-terminally extended; Sequence=CAA62153.1; Type=Erroneous initiation; Note=Translation N-terminally

extended;

6/114 PDB 3D structures from and Proteopedia for PPARG (see all 114):

1FM6 (3D)

1FM9 (3D)

1I7I (3D)

1K74 (3D)

1KNU (3D)

1NYX (3D)

Secondary accessions: A8K3G6 B5BUA1 O00684 O00710 O14515 Q0QJH8 Q15178 Q15179 Q15180 Q15832 Q86U60

Q96J12

Alternative splicing: 3 isoforms: P37231-1 P37231-2 P37231-3 (Exhibits dominant negative activity over isoform 1)

Explore the universe of human proteins at neXtProt for PPARG: NX_P37231

Post-translational modifications:

O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P37231

PPARG Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_005028.4 NP_056953.2 NP_619725.2 NP_619726.2

ENSEMBL proteins:

ENSP00000380205 ENSP00000380224 ENSP00000312472 ENSP00000380210 ENSP00000411931

ENSP00000380207 ENSP00000380221 ENSP00000392285 ENSP00000380196 ENSP00000287820

ENSP00000380218 ENSP00000380195 ENSP00000438940

Reactome Protein details: P37231
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 4): PPARG OriGene Protein Over-expression Lysate (see all 5): PPARG OriGene Custom Protein Services for PPARG
	GenScript Custom Purified and Recombinant Proteins Services for PPARG
	Novus Biologicals PPARG Proteins Novus Biologicals PPARG Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PPARG
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	9568716
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	ISS	--

PPARG for ontologies About GeneDecksing

PPARG Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PPARG
	R&D Systems Antibodies for PPARG (PPAR gamma/NR1C3)
	Cell Signaling Technology (CST) Antibodies for PPARG (PPAR-gamma)
	OriGene Antibodies: PPARG OriGene Custom Antibody Services for PPARG
	GenScript Custom Superior Antibodies Services for PPARG
	Novus Biologicals PPARG Antibodies
	Search for Antibodies for PPARG at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibody for PPARG

Assay Products for PPARG:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PPARG
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PPARG for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR008946 Nucl_hormone_rcpt_ligand-bd

IPR003077 1Cnucl_rcpt_G

IPR001723 Str_hrmn_rcpt

IPR003074 1Cnucl_rcpt

IPR013088 Znf_NHR/GATA

Graphical View of Domain Structure for InterPro Entry P37231

ProtoNet protein and cluster: P37231

3 Blocks protein families:

IPB001723 Steroid hormone receptor signature

IPB003074 Peroxisome proliferator-activated receptor (1C nuclear receptor) signature

IPB003077 Peroxisome proliferator-activated receptor gamma signature

UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231

Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231

Function: Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a

ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It

therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation

and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated

proinflammatory responses

Enzyme regulation: PDPK1 activates its transcriptional activity independently of its kinase activity

Genatlas biochemistry entry for PPARG:

peroxisome proliferator-activated receptor,steroid/thyroid hormone coactivator receptor superfamily,heterodimerizing

with RXR*,coactivated by SRCO1,expressed (isoform 1) in the diploid trophoblast lineages and required for placental

development,expressed at low levels in preadipocytes,induced by CEBPB and CEBPD,coexpressed with and coregulated by

PPARG,jointly required for full adipocyte differentiation and fat deposition with variability influencing plasma

leptin levels in obese humans,modulator of insulin sensitivity and control of glucose homostasis and blood pressure

and activation of antidiabetic effect of thiazolidinediones,negative regulator of macrophage activation,inhibiting

production of monocyte inflammatory cytokines,increasing PAI1 expression in endothelial cells.

miRNA Products:		miRTarBase miRNAs that target PPARG: hsa-mir-27b (MIRT005023), hsa-mir-20b (MIRT004000), hsa-mir-130a (MIRT005957), hsa-mir-130b (MIRT005958), hsa-mir-138 (MIRT005489)

		OriGene 3'-UTR Clone (see all 4): PPARG Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPARG
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate PPARG (see all 26):
		hsa-miR-548j hsa-miR-548i hsa-miR-513a-5p hsa-miR-128 hsa-miR-301a hsa-miR-889 hsa-miR-548d-5p hsa-miR-548a-5p

		SwitchGear 3'UTR luciferase reporter plasmid: PPARG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPARG (see all 7) OriGene shRNA RFP: PPARG OriGene siRNA: PPARG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPARG

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PPARG

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPARG (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PPARG (see all 8) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): PPARG (NM_138712)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPARG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPARG

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PPARG
		Search LifeMap BioReagents cell lines for PPARG

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPARG

Gene Ontology (GO): 5/18 molecular function terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001012	RNA polymerase II regulatory region DNA binding	IEA	--
GO:0003677	DNA binding	ISS	--
GO:0003682	chromatin binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	ISS	--
GO:0003707	steroid hormone receptor activity	IEA	--

PPARG for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for PPARG: Pparg^tm1.2Mgn Pparg^tm1Wwah Pparg^tm2Avp Pparg^tm1.2Gonz Pparg^tm1Uls Pparg^tm1.1Mtz
                                               Pparg^tm1Tka
     15/23 MGI mutant phenotypes (inferred from 26 alleles) (MGI details for Pparg) (see all 23):

adipose tissue	behavior/neurological	cardiovascular system	cellular	embryogenesis
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	integument	liver/biliary system	mortality/aging	muscle

PPARG for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Maintenance of PPARG Expression in Differentiated Adipocytes

	Maintenance of PPARG Expression in Differentiated Adipocytes	1.00			Thyroid cancer	0.03
	Expression of PPARG	1.00

Nuclear Receptor transcription pathway

Nuclear Receptor transcription pathway

1.00

Nuclear Receptors

0.68

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

G-protein signaling_Ras family GTPases in kinase cascades (scheme)

Immune response Oncostatin M signaling via MAPK in human cells

0.39

Immune response_Oncostatin M signaling via MAPK in human cells

0.39

Development_Ligand-independent activation of ESR1 and ESR2

Transcription PPAR Pathway

0.35

Transcription_PPAR Pathway

0.35

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for PPARG

	Transcription PPAR Pathway
	Development Beta-adrenergic receptors signaling via cAMP
	Immune response Oncostatin M signaling via MAPK in human cells

1 R&D Systems Pathway for PPARG

TGF-beta Signaling Pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PPARG

PPAR Pathway

1 Cell Signaling Technology (CST) Pathway for PPARG

Glucose / Energy Metabolism

1 Tocris Bioscience Pathway for PPARG

mTOR Pathway

3 GeneGo (Thomson Reuters) Pathways for PPARG

	Development Beta-adrenergic receptors signaling via cAMP
	Transcription PPAR Pathway
	Immune response Oncostatin M signaling via MAPK in human cells

5/9 BioSystems Pathways for PPARG (see all 9)

	Adipogenesis
	Nuclear Receptors
	SREBP signalling
	Nuclear receptors in lipid metabolism and toxicity
	Energy Metabolism

5/7 Reactome Pathways for PPARG (see all 7)

	Developmental Biology
	Transcriptional Regulation of White Adipocyte Differentiation
	Expression of PPARG
	Generic Transcription Pathway
	Maintenance of PPARG Expression in Differentiated Adipocytes

1 PharmGKB Pathway for PPARG

Celecoxib Pathway, Pharmacodynamics

5 Kegg Pathways (Kegg details for PPARG):

	PPAR signaling pathway
	Osteoclast differentiation
	Huntington's disease
	Pathways in cancer
	Thyroid cancer

PPARG for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PPARG

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/148 Interacting proteins for PPARG (P37231^{1, 2, 3} ENSP00000287820⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 148)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPARGC1A	Q9UBK2²^,³, ENSP00000264867⁴	MINT-7229698 MINT-7229685 I2D: score=2 STRING: ENSP00000264867
EDF1	O60869¹^,³, ENSP00000224073⁴	EBI-781384,EBI-781301 I2D: score=3 STRING: ENSP00000224073
CLU	P10909¹^,³, ENSP00000315130⁴	EBI-781384,EBI-1104674 I2D: score=1 STRING: ENSP00000315130
MED1	Q15648³, ENSP00000300651⁴	I2D: score=5 STRING: ENSP00000300651
HDAC3	O15379³, ENSP00000302967⁴	I2D: score=4 STRING: ENSP00000302967

About this table

Gene Ontology (GO): 5/63 biological process terms (GO ID links to tree view) (see all 63): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	ISS	--
GO:0001890	placenta development	ISS	--
GO:0002674	negative regulation of acute inflammatory response	IEA	--
GO:0006351	transcription, DNA-dependent	--	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	--	--

PPARG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PPARG for compounds About GeneDecksing

EMD Millipore small molecules for PPARG:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for PPARG

Compounds for PPARG available from Tocris Bioscience About this table

Compound	Action	CAS #
Troglitazone	Selective PPARgamma agonist; antidiabetic agent	[97322-87-7]
GW 1929 hydrochloride	Selective PPARgamma agonist. Orally active	[196808-24-9]
nTZDpa	Potent, selective PPARgamma partial agonist	[118414-59-8]
T 0070907	Highly potent and selective PPARgamma antagonist	[313516-66-4]
Pioglitazone hydrochloride	Selective PPARgamma agonist; antidiabetic agent	[112529-15-4]

10/43 HMDB Compounds for PPARG (see all 43) About this table

Compound	Synonyms	CAS #	PubMed Ids
Butyric acid	1-Butyrate (see all 25)	107-92-6	16927016
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
3Z-dodecenoyl-CoA	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)	2152-91-2	--
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--

10/37 DrugBank Compounds for PPARG (see all 37) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Telmisartan	BIBR 277 (see all 2)	144701-48-4	target	partial agonist	15868121 17691961 18580862 15617852 19147680 16938288 16154710
Troglitazone	--	97322-87-7	target	agonist	10222233 10200320 12475986 10214942 10076568 11752352 10097144
Pioglitazone	Pioglitazona [INN-Spanish] (see all 5)	111025-46-8	target	agonist	9568680 7768881 11752352 20018750 15356026 8576907
Rosiglitazone	Rosigliazone maleate (see all 2)	122320-73-4	target	agonist	10764590 10548525 10475242 10871190 11752352 10707565
Icosapent	Eicosapentaenoic acid (see all 4)	10417-94-4	target	agonist	11552681 16702329 17052999 12055328 17610002
Balsalazide	Balsalazida [Spanish] (see all 4)	80573-04-2	target	agonist	16939423 20151072 18077625 19708827
Mesalazine	5-aminosalicylate (see all 4)	89-57-6	target	agonist	16939423 15824083 18544567 18077625
Sulfasalazine	Sulfasalazin (see all 2)	599-79-1	target	agonist	16939423 15824083 18544567 18077625
(2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid	--	--	target	--	10592235
(2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid	--	--	target	--	10592235

10/130 Novoseek chemical compound relationships for PPARG gene (see all 130) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rosiglitazone	96.6	1156	10871190 (6), 18630997 (6), 16425225 (5), 18640979 (5) (see all 99)
15-deoxy-delta-12,14-prostaglandin j2	96.2	785	12401880 (6), 17643887 (6), 11159824 (5), 16198309 (5) (see all 99)
troglitazone	95.7	829	10871190 (8), 9709955 (7), 12475986 (6), 16303758 (5) (see all 99)
gw9662	95.6	391	16696951 (6), 12022867 (6), 18203887 (3), 15533890 (3) (see all 99)
ciglitazone	95.2	363	12697971 (5), 19288012 (5), 17621259 (4), 14587029 (3) (see all 99)
pioglitazone	94.7	536	17643887 (5), 12610044 (4), 16210596 (4), 17037742 (4) (see all 99)
thiazolidinedione	93.9	383	10075686 (6), 14713549 (4), 9832442 (4), 17390024 (3) (see all 99)
gw 1929	85.8	35	15677767 (2), 11358817 (1), 11597575 (1), 15517883 (1) (see all 21)
pgj-2	84.8	67	15254749 (7), 14600076 (5), 14971050 (3), 14751245 (2) (see all 28)
prostaglandin j2	84.3	25	8725145 (1), 11668172 (1), 16842938 (1), 10781090 (1) (see all 20)

Search CenterWatch for drugs/clinical trials and news about PPARG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PPARG gene (4 alternative transcripts):

NM_005037.5 NM_015869.4 NM_138711.3 NM_138712.3

Unigene Cluster for PPARG:

Peroxisome proliferator-activated receptor gamma

Hs.162646 [show with all ESTs]

Unigene Representative Sequence: AB472042

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000397010 ENST00000397029 ENST00000309576(uc003bwr.3 uc003bws.3 uc003bwv.3)

ENST00000397015 ENST00000455517 ENST00000397012(uc010hdz.1 uc003bwu.3)

ENST00000397026 ENST00000497594(uc003bwt.1) ENST00000438682 ENST00000397000

ENST00000477039(uc003bww.1) ENST00000287820(uc003bwx.3) ENST00000397023

ENST00000396999(uc010hea.1) ENST00000539812

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Additional cDNA sequence:

AB097931.1 AB107271.1 AB307692.1 AB451337.1 AB451486.1 AB472042.1 AB565476.1 AJ563369.1

AJ563370.1 AJ698135.1 AK223528.1 AK290581.1 BC006811.1 BT007281.1 D83233.1 DQ356894.1

HQ692866.1 U63415.1 U79012.1 X90563.1

11 DOTS entries:

DT.112942 DT.100791622 DT.100791623 DT.100791631 DT.75152583 DT.120867762 DT.97811244 DT.100791626

DT.100791629 DT.120867823 DT.95371767

24/116 AceView cDNA sequences (see all 116):

BF811102 AI767379 BC006811 CR599329 BG742110 AI200451 BT007281 AI280973

BU618129 AW628342 BQ012686 BQ021210 AB097931 BQ722874 CD101663 BU626490

AI355115 AL543579 U63415 BM790089 BM995901 NM_005037 CR605352 BF514811

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PPARG (see all 9) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	^	10a	·	10b	^	11	^	12	^	13a	·	13b	·	13c
SP1:											-		-						-
SP2:							-		-		-		-		-		-		-
SP3:
SP4:																			-																				-
SP5:							-		-		-		-						-

ECgene alternative splicing isoforms for PPARG

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PPARG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTCTTCACC

About this image

PPARG expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/41 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 41)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Body Subcutaneous White Adipose

Subcutaneous White Adipocytes

Selective marker (cell-identifying gene)

Adipose

Body Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Cervical Brown Adipose Depot

Cervical Brown Adipocyte Cells

Adipose

Cervical Brown Adipose Depot

Cervical Committed Brown Preadipocytes

Adipose

Cranial Subcutaneous White Adipose

Preadipocytes

Adipose

Cranial Subcutaneous White Adipose

Subcutaneous White Adipocytes

Adipose

Cranial Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Facial Subcutaneous White Adipose

Preadipocytes

Adipose

Facial Subcutaneous White Adipose

Subcutaneous White Adipocytes

Adipose

Facial Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/14 LifeMap Cells (see all 14)

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

Immature adipocyte-like cells (Differentiation of ...)

Adipose

White adipocyte-like cells (Differentiation of ...)

Adipose

Brown adipocyte-like cells (Differentiation of ...)

Adipose

Brown adipocyte-like cells (Directed differentia...)

Adipose

Adipocyte-like cells (Generation of adipoc...)

White adipocyte-like cells (Differentiation of w...)

Brown adipocyte-like cells (Differentiation of w...)

Syncytiotrophoblast-like cells (Generation of syncyt...)

CD31, CD144 positive cells (Two-step protocol fo...)

See PPARG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PPARG

SOURCE GeneReport for Unigene cluster: Hs.162646

UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231

Tissue specificity: Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also

detectable in placenta, lung and ovary

SABiosciences Expression via Pathway-Focused PCR Arrays including PPARG (see all 21):

Insulin Signaling Pathway in human mouse rat

Stem Cell Transcription Factors in human mouse rat

Adipogenesis in human mouse rat

Mesenchymal Stem Cell in human mouse rat

Telomeres & Telomerase in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PPARG gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PPARG¹	peroxisome proliferator-activated receptor gamma	82.25(n) 92.84(a)		373928 NM_001001460.1 NP_001001460.1
lizard (Anolis carolinensis)	Reptilia	PPARG⁶	--	90(a)	1 ↔ 1	2(158830158-158864559)
African clawed frog (Xenopus laevis)	Amphibia	PPARg²	peroxisome proliferator activated receptor gamma	77.61(n)		BC060474.1
zebrafish (Danio rerio)	Actinopterygii	pparg¹	peroxisome proliferator activated receptor gamma	67.02(n) 69.34(a)		557037 NM_131467.1 NP_571542.1
worm (Caenorhabditis elegans)	Secernentea	sex-1³	nuclear hormone receptor	27(a)		X(10236789-10240655) --

ENSEMBL Gene Tree for PPARG (if available)
TreeFam Gene Tree for PPARG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PPARG gene

RORC² NR1D2² PPARD² RORA² NR1D1² PPARA² RORB²

18/36 SIMAP similar genes for PPARG using alignment to 12 protein entries: PPARG_HUMAN (see all proteins) (see all similar genes):

NR1C3 ppar gamma2 PPARD NR1C2 NR1C1 NR1F3

NR3C2 RORC HNF4G VDR RXRB PPARA

NR6A1 NR1F2 NR1F1 RORB NR2F1 RXRA

PPARG for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231

Polymorphism: Genetic variation in PPARG may influence body mass index (BMI) [MIM:606641]. BMI reflects the amount of

fat, lean mass, and body build

Polymorphism: Genetic variations in PPARG influence the carotid intimal medial thickness (CIMT) [MIM:609338]. CIMT is a

measure of atherosclerosis that is independently associated with traditional atherosclerotic cardiovascular disease

risk factors and coronary atherosclerotic burden. 35 to 45% of the variability in multivariable-adjusted CIMT is

explained by genetic factors

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1801282^1,2	C,F,H,	pathogenic	12393125(+)	`TTGACC/GCAGAA`	5	P A	int¹ mis¹		56		NS MN EU NA EA	13480
rs72551364^1,2	C	pathogenic	120126609(+)	`CAGACC/TGCCCA`	8	R C	mis¹		0	--	--	--	--
rs72551363^1,2	C	pathogenic	120143449(+)	`CCTTTA/TGGTGA`	8	L F	mis¹		0	--	--	--	--
rs72551362^1,2	C	pathogenic	120143661(+)	`GCTCCA/GTGGAG`	8	M V	mis¹		0	--	--	--	--
rs1800571^1,2	C	pathogenic	120179135(+)	`ATCTCC/AACCTT`	8	/Q /P	mis¹		3		NA	736
rs1805192^1,2	C	pathogenic	120180745(+)	`TCTGGC/GCCACC`	8	P A	mis¹		8		MN NA	1132
rs3856806^1,2	C,F,A,H,	other	120126451(+)	`GAACAC/TGTGCA`	8	H	syn¹ ese³		47		MN NS EU NA EA CSA WA	12384
rs9880344^1,2	C	--	12261160(+)	`gcaatC/Atcggc`	2	--	us2k¹ tfbs³		2		NA	4
rs17028996^1,2	C,F,	--	12261187(+)	`CCAGGG/TTCAAG`	2	--	us2k¹		3		NS CSA	78
rs9714363^1,2	C	--	12261209(+)	`cctcaG/Tccccc`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PPARG (12328867 - 12475855 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PPARG
2 Indels: 42164 62033
1 Inversion: 37239
Human Gene Mutation Database (HGMD): PPARG

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PPARG for disorders           About GeneDecksing

OMIM gene information: 601487
OMIM disorders: 601665  137800  604367  609338  125853
UniProtKB/Swiss-Prot: PPARG_HUMAN, P37231

Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be

associated with colon cancer

Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition

characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result

of excessive accumulation of body fat

Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:604367]. Familial partial

lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous

(sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes

mellitus and dyslipidemia

Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:137800].

Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma

multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly

over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible

contribution to disease susceptibility

20/270 diseases for PPARG (see all 270): About MalaCards

carotid intimal medial thickness carotid intimal medial thickness 1 obesity insulin resistance, severe, digenic

acth-secreting pituitary adenoma atherosclerosis familial partial lipodystrophy type 3 familial partial lipodystrophy

salivary gland cancer bowenoid papulosis familial adenomatous polyposis retinol binding protein

non-small cell lung carcinoma central nervous system disease metabolic syndrome x nelson syndrome

9 diseases from the University of Copenhagen DISEASES database for PPARG:

Diabetes mellitus Atherosclerosis Hyperglycemia Lipodystrophy

Cancer Hypertension Fatty liver disease Heart disease

Hyperinsulinism

10/95 Novoseek disease relationships for PPARG gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
insulin sensitivity	86.4	343	20182551 (4), 19390629 (3), 15637349 (3), 16920849 (2) (see all 99)
insulin resistance	86.2	403	16305809 (5), 11533050 (5), 11872365 (5), 16508313 (4) (see all 99)
obesity	76.9	237	9806316 (4), 12709137 (4), 16716756 (4), 10762291 (3) (see all 99)
niddm	75.3	147	15558556 (5), 19846173 (3), 16920849 (2), 17884451 (2) (see all 96)
atherosclerosis	73.2	186	12682906 (3), 11790295 (3), 9636198 (2), 11742860 (2) (see all 99)
lipodystrophy, familial partial	73.2	26	17766367 (3), 17299075 (2), 17312272 (2), 19748282 (1) (see all 13)
dyslipidemia	71.3	45	15491498 (3), 15684639 (1), 19636418 (1), 19749155 (1) (see all 33)
inflammation	71	387	18382616 (5), 18400717 (4), 19828904 (4), 16614990 (3) (see all 99)
partial lipodystrophy	70.3	21	17356052 (4), 15711581 (3), 12453919 (2), 19749155 (2) (see all 12)
lipodystrophy	69.1	38	19125203 (3), 19534662 (3), 18954260 (2), 15254581 (2) (see all 21)

Genatlas disease: PPARG

marked obesity with a high body-mass index and a defect in the regulation of adipocyte differentiation associated with

type 2 diabetes

Genetic Association Database (GAD): PPARG
Human Genome Epidemiology (HuGE) Navigator: PPARG (615 documents)

Export disorders for PPARG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PPARG gene, integrated from 9 sources (see all 3894):
(articles sorted by number of sources associating them with PPARG)

Utopia: connect your pdf to the dynamic
world of online information

Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis. (PubMed id 15356014)^{1, 2, 4} Temelkova-Kurktschiev T....Laakso M. (2004)
A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones. (PubMed id 19147680)^{1, 7, 9} Tagami T....Naruse M. (2009)
[Clinical genetic determinants of carbohydrate metabolism disturbances in patients with hypertension and excessive weight] (PubMed id 15940190)^{1, 4, 9} Kobalava Z.h.D....Moiseev V.S. (2005)
PPARgamma gene polymorphism is associated with exercise-mediated changes of insulin resistance in healthy men. (PubMed id 12601634)^{1, 4, 9} Kahara T....Kobayashi K. (2003)
[Clinicogenetic aspects of carbohydrate metabolism disorders and efficacy of their correction with moxonidine and metformine in patients with arterial hypertension] (PubMed id 15759454)^{1, 4, 9} Kobalava Z.h.D....Zheleznykh E.A. (2005)
Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level? (PubMed id 14681835)^{1, 4, 9} Franks P.W....Wareham N.J. (2004)
Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction. (PubMed id 12663371)^{1, 4, 9} Ridker P.M....Zee R.Y. (2003)
Loss-of-function mutations in PPAR-gamma associated with human colon cancer. (PubMed id 10394368)^{1, 2, 9} Sarraf P.... Eng C. (1999)
No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARdelta and PPARgamma act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma. (PubMed id 16141797)^{1, 4, 9} McGreavey L.E....Barrett J.H. (2005)
Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and body composition in males. (PubMed id 15015141)^{1, 4, 9} Damcott C.M....Ferrell R.E. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5468	HGNC: 9236	AceView: PPARG	Ensembl:ENSG00000132170	euGenes: HUgn5468
ECgene: PPARG	Kegg: 5468	H-InvDB: PPARG

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PPARG	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PPARG	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PPARG
SeattleSNPs	http://pga.gs.washington.edu/data/pparg/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=PPARG

Intellectual Property for PPARG gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PPARG gene:
Search GeneIP for patents involving PPARG

Licensable Technologies for PPARG gene:

Salk Institute:

Use of RAR Antagonists as Modulators of Hormone Mediated Processes

(see all 4)

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PPARG gene at Home site.

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PPARG Gene

peroxisome proliferator-activated receptor gamma

Aliases
for PPARG gene

Summaries
for PPARG gene

Genomic Views
for PPARG gene

Proteins
for PPARG gene

Protein Domains /
Families
for PPARG gene

Function
for PPARG gene

Pathways & Interactions
for PPARG gene

Drugs & Compounds
for PPARG gene

Transcripts
for PPARG gene

Expression
for PPARG gene

Orthologs
for PPARG gene

Paralogs
for PPARG gene

Genomic Variants
for PPARG gene

Disorders / Diseases
for PPARG gene

Publications
for PPARG gene

External Searches for PPARG gene

Genome Databases showing PPARG gene

Other Databases showing PPARG gene

Specialized Databases showing PPARG gene

Intellectual Property
for PPARG gene

Products
for PPARG gene

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Fatty Liver
Microalbuminuria
Bone Loss Age-Related
familial adenomatous polyposis
Hyperinsulinemia
Retinoblastoma
Genetic Susceptibility
Pituitary Tumors
THYROID CARCINOMA ANAPLASTIC
THYROID FOLLICULAR CARCINOMA
Urological Cancer
Colitis Ulcerative
Hyperlipidemia
Glucose Intolerance
LUNG CARCINOMA
insulin sensitivity
Atherosclerosis
Liver diseases
Breast Cancer
Prediabetic State
NSCLC
Edema
Cancer
Colorectal Carcinoma
LIPODYSTROPHY, FAMILIAL PARTIAL
Colonic Polyps
bone loss
follicular thyroid cancer
Lipid Disorders
Carcinoma Non-Small Cell Lung
Dyslipidemia
RENAL DISEASE
Colorectal Cancer
Multiple Sclerosis
Inflammation
Diabetic Nephropathies
Thyroid Neoplasms
Monocytic leukemia
Hyperglycemia
Hypertrophy
prostate cancer
Tumors
Cardiovascular Diseases
Necrosis
metabolic disorder
Glioblastoma
Tangier Disease
Hyperandrogenism
COLON TUMOR
Senile Plaques
Colitis
Intestinal Polyps
Neurodegenerative Diseases
Colon Cancer
Pulmonary Fibrosis
Adenoma Follicular
PITUITARY ADENOMA
atherosclerotic plaque
Liver Fibrosis
PARTIAL LIPODYSTROPHY
PERIPHERAL EDEMA
Liposarcoma
Thyroid Cancer
Alzheimers Disease
Diabetes Mellitus
Carcinoma Papillary
Effects Cardiovascular
Arteriosclerosis
THYROID PAPILLARY CARCINOMA
Metabolic Syndrome X
Pancreatic Cancer
Cancer Lung
Inflammatory Bowel Diseases
Salivary Gland Cancer
Albuminuria
THYROID ADENOMA
Coronary Artery Disease
Insulin Resistance
impaired glucose tolerance
Adenoma
Hypertriglyceridemia
OBESITY
Lipodystrophy
Polycystic Ovary Syndrome
restenosis
papillary thyroid cancer
Lichen planopilaris
fluid retention
Vascular Diseases
LIPODYSTROPHY, CONGENITAL GENERALIZED
NIDDM
Chronic obstructive asthma
THYROID CARCINOMA
Nelson Syndrome
Choriocarcinoma

Advanced Search

Export list of displayed genes

PPARG Gene

peroxisome proliferator-activated receptor gamma

Aliasesfor PPARG gene

Summariesfor PPARG gene

Genomic Viewsfor PPARG gene

Proteinsfor PPARG gene

Protein Domains /Familiesfor PPARG gene

Functionfor PPARG gene

Pathways & Interactionsfor PPARG gene

Drugs & Compoundsfor PPARG gene

Transcriptsfor PPARG gene

Expression for PPARG gene

Orthologsfor PPARG gene

Paralogsfor PPARG gene

Genomic Variantsfor PPARG gene

Disorders / Diseasesfor PPARG gene

Publicationsfor PPARG gene

External Searches for PPARG gene

Genome Databases showing PPARG gene

Other Databases showing PPARG gene

Specialized Databases showing PPARG gene

Intellectual Propertyfor PPARG gene

Productsfor PPARG gene

View Random Gene

Aliases
for PPARG gene

Summaries
for PPARG gene

Genomic Views
for PPARG gene

Proteins
for PPARG gene

Protein Domains /
Families
for PPARG gene

Function
for PPARG gene

Pathways & Interactions
for PPARG gene

Drugs & Compounds
for PPARG gene

Transcripts
for PPARG gene

Expression
for PPARG gene

Orthologs
for PPARG gene

Paralogs
for PPARG gene

Genomic Variants
for PPARG gene

Disorders / Diseases
for PPARG gene

Publications
for PPARG gene

Intellectual Property
for PPARG gene

Products
for PPARG gene