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Aliases for PPARG Gene

Aliases for PPARG Gene

  • Peroxisome Proliferator-Activated Receptor Gamma 2 3
  • Nuclear Receptor Subfamily 1 Group C Member 3 3 4
  • PPAR-Gamma 3 4
  • PPARG1 3 6
  • PPARG2 3 6
  • CIMT1 3 6
  • NR1C3 3 4
  • GLM1 3 6
  • Peroxisome Proliferator-Activated Nuclear Receptor Gamma Variant 1 3
  • Peroxisome Proliferative Activated Receptor, Gamma 2
  • PPARgamma 3

External Ids for PPARG Gene

Previous GeneCards Identifiers for PPARG Gene

  • GC03P012258
  • GC03P012304
  • GC03P012305
  • GC03P012263

Summaries for PPARG Gene

Entrez Gene Summary for PPARG Gene

  • This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPARG Gene

PPARG (Peroxisome Proliferator-Activated Receptor Gamma) is a Protein Coding gene. Diseases associated with PPARG include obesity and carotid intimal medial thickness 1. Among its related pathways are Pathways in cancer and L1CAM interactions. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is NR1I2.

UniProtKB/Swiss-Prot for PPARG Gene

  • Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).

Tocris Summary for PPARG Gene

  • Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression. PPARgamma is located primarily in the adipose tissue, lymphoid tissue, colon, liver and heart and is thought to regulate adipocyte differentiation and glucose homeostasis. PPARgamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. The human gene encoding PPARgamma has been localized to chromosome 3 (3p25).

Gene Wiki entry for PPARG Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPARG Gene

Genomics for PPARG Gene

Regulatory Elements for PPARG Gene

Genomic Location for PPARG Gene

Start:
12,287,368 bp from pter
End:
12,434,356 bp from pter
Size:
146,989 bases
Orientation:
Plus strand

Genomic View for PPARG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPARG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPARG Gene

Proteins for PPARG Gene

  • Protein details for PPARG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P37231-PPARG_HUMAN
    Recommended name:
    Peroxisome proliferator-activated receptor gamma
    Protein Accession:
    P37231
    Secondary Accessions:
    • A8K3G6
    • B5BUA1
    • O00684
    • O00710
    • O14515
    • Q0QJH8
    • Q15178
    • Q15179
    • Q15180
    • Q15832
    • Q86U60
    • Q96J12

    Protein attributes for PPARG Gene

    Size:
    505 amino acids
    Molecular mass:
    57620 Da
    Quaternary structure:
    • Interacts with FOXO1 (acetylated form) (By similarity). Heterodimer with other nuclear receptors, such as RXRA. The heterodimer with the retinoic acid receptor RXRA is called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 and NCOA2 LXXLL motifs. Interacts with ASXL1, ASXL2, DNTTIP2, FAM120B, MAP2K1/MEK1, NR0B2, PDPK1, PRDM16, PRMT2 and TGFB1I1. Interacts (when activated by agonist) with PPP5C. Interacts with HELZ2 and THRAP3; the interaction stimulates the transcriptional activity of PPARG. Interacts with PER2, the interaction is ligand dependent and blocks PPARG recruitment to target promoters. Interacts with CCRN4L/NOC. Interacts with ACTN4.
    SequenceCaution:
    • Sequence=AAN38992.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA23354.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAF83270.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA62153.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPARG Gene

    Alternative splice isoforms for PPARG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPARG Gene

Proteomics data for PPARG Gene at MOPED

Post-translational modifications for PPARG Gene

  • O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes.
  • Phosphorylated in basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation at Ser-112 induces adipogenic activity (By similarity).
  • Glycosylation at Thr84
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PPARG (PPAR gamma/NR1C3)
  • Cell Signaling Technology (CST) Antibodies for PPARG (PPAR-gamma)

No data available for DME Specific Peptides for PPARG Gene

Domains for PPARG Gene

Gene Families for PPARG Gene

Graphical View of Domain Structure for InterPro Entry

P37231

UniProtKB/Swiss-Prot:

PPARG_HUMAN :
  • P37231
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
genes like me logo Genes that share domains with PPARG: view

Function for PPARG Gene

Molecular function for PPARG Gene

GENATLAS Biochemistry: peroxisome proliferator-activated receptor,steroid/thyroid hormone coactivator receptor superfamily,heterodimerizing with RXR*,coactivated by SRCO1,expressed (isoform 1) in the diploid trophoblast lineages and required for placental development,expressed at low levels in preadipocytes,induced by CEBPB and CEBPD,coexpressed with and coregulated by PPARG,jointly required for full adipocyte differentiation and fat deposition with variability influencing plasma leptin levels in obese humans,modulator of insulin sensitivity and control of glucose homostasis and blood pressure and activation of antidiabetic effect of thiazolidinediones,negative regulator of macrophage activation,inhibiting production of monocyte inflammatory cytokines,increasing PAI1 expression in endothelial cells.
UniProtKB/Swiss-Prot EnzymeRegulation: PDPK1 activates its transcriptional activity independently of its kinase activity.
UniProtKB/Swiss-Prot Function: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).

Gene Ontology (GO) - Molecular Function for PPARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001012 RNA polymerase II regulatory region DNA binding IEA --
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding ISS --
GO:0003682 chromatin binding ISS --
genes like me logo Genes that share ontologies with PPARG: view
genes like me logo Genes that share phenotypes with PPARG: view

Animal Models for PPARG Gene

MGI Knock Outs for PPARG:

Animal Model Products

CRISPR Products

Targeting motifs for PPARG Gene
HOMER Transcription Factor Regulatory Elements motif PPARG
  • Consensus sequence: TGACCTTTGCCCCA Submotif: DR1 Cell Type: 3T3L1 GeoId: GSE13511

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for PPARG Gene

Localization for PPARG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPARG Gene

Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. CCRN4L/NOC enhances its nuclear translocation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPARG Gene COMPARTMENTS Subcellular localization image for PPARG gene
Compartment Confidence
nucleus 5
peroxisome 4
cytosol 3
extracellular 3
mitochondrion 3
cytoskeleton 2
endoplasmic reticulum 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PPARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9568716
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol ISS --
GO:0048471 perinuclear region of cytoplasm IEA --
GO:0090575 RNA polymerase II transcription factor complex IDA 9568716
genes like me logo Genes that share ontologies with PPARG: view

Pathways for PPARG Gene

genes like me logo Genes that share pathways with PPARG: view

PCR Array Products

Gene Ontology (GO) - Biological Process for PPARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001890 placenta development ISS --
GO:0002674 negative regulation of acute inflammatory response IEA --
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with PPARG: view

Compounds for PPARG Gene

(5) Tocris Compounds for PPARG Gene

Compound Action Cas Number
GW 1929 hydrochloride Selective PPARgamma agonist. Orally active [1217466-21-1]
GW 9662 Selective PPARgamma antagonist [22978-25-2]
Pioglitazone hydrochloride Selective PPARgamma agonist; antidiabetic agent [112529-15-4]
T 0070907 Highly potent and selective PPARgamma antagonist [313516-66-4]
Troglitazone Selective PPARgamma agonist; antidiabetic agent [97322-87-7]

(43) HMDB Compounds for PPARG Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(40) IUPHAR Ligand for PPARG Gene

Ligand Type Action Affinity Pubmed IDs
T0070907 Antagonist Antagonist 9
GW1929 Agonist Full agonist 8.84
GW409544 Agonist Agonist 8.7
L-796449 Agonist Full agonist 8.7
SB-219994 Agonist Full agonist 8.68
LG100754 Antagonist Antagonist 8.47
GW7845 Agonist Full agonist 8.43
L-783483 Agonist Agonist 8.2
CDDO Agonist Partial agonist 8
L-165461 Agonist Full agonist 7.8
AD5075 Agonist Full agonist 7.66
[3H]AD5075 Agonist Full agonist 7.66
MK-0767 Agonist Agonist 7.64
TZD18 Agonist Agonist 7.6
LY-510929 Agonist Agonist 7.55
L-764406 Agonist Partial agonist 7.15
[125I]SB-236636 Agonist Full agonist 7.1
thiazolidinone Agonist Partial agonist 7
CDDO-Me Antagonist Antagonist 6.89
LY-465608 Agonist Agonist 6.8
nTzDpa Agonist Partial agonist 6.5
farglitazar Agonist Agonist 6.35
PAT5A Agonist Partial agonist 6.35
netoglitazone Agonist Full agonist 6.3
15-deoxy-delta 12 14-prostaglandin J2 Agonist Full agonist 6.3
ragaglitazar Agonist Agonist 6
FMOC-L-Leucine Agonist Partial agonist 6
GW9578 Agonist Full agonist 5.9
reglitazar Agonist Agonist 5.72
AD-5061 Agonist Agonist 5.6
SB-219993 Agonist Full agonist 5.5
ciglitazone Agonist Full agonist 4.64
diclofenac Channel blocker None 4
BADGE Antagonist Antagonist 4
indomethacin Inhibitor Inhibition 3.7
rosiglitazone Channel blocker None
pioglitazone Channel blocker None
troglitazone Channel blocker None
linoleic acid Channel blocker None
GW9662 Antagonist Antagonist

(130) Novoseek inferred chemical compound relationships for PPARG Gene

Compound -log(P) Hits PubMed IDs
rosiglitazone 96.6 269
15-deoxy-delta-12,14-prostaglandin j2 96.2 231
troglitazone 95.7 255
gw9662 95.6 129
ciglitazone 95.2 161

(1) PharmGKB related drug/compound annotations for PPARG Gene

Drug/compound Annotation
aspirin CA
genes like me logo Genes that share compounds with PPARG: view

Transcripts for PPARG Gene

Unigene Clusters for PPARG Gene

Peroxisome proliferator-activated receptor gamma:
Representative Sequences:

CRISPR Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPARG Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2: - - - - - - -
SP3:
SP4: - -
SP5: - - - - -
SP6: - -
SP7: -
SP8: - - - - - - -
SP9: - - - - -

Relevant External Links for PPARG Gene

GeneLoc Exon Structure for
PPARG
ECgene alternative splicing isoforms for
PPARG

Expression for PPARG Gene

mRNA expression in normal human tissues for PPARG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPARG Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (9.0), Adipose - Subcutaneous (8.6), and Breast - Mammary Tissue (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PPARG Gene

SOURCE GeneReport for Unigene cluster for PPARG Gene Hs.162646

mRNA Expression by UniProt/SwissProt for PPARG Gene

P37231-PPARG_HUMAN
Tissue specificity: Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.
genes like me logo Genes that share expressions with PPARG: view

In Situ Assay Products

Orthologs for PPARG Gene

This gene was present in the common ancestor of animals.

Orthologs for PPARG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPARG 35
  • 99.54 (n)
  • 99.8 (a)
PPARG 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPARG 35
  • 91.02 (n)
  • 95.84 (a)
PPARG 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPARG 35
  • 92.34 (n)
  • 98.22 (a)
PPARG 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pparg 35
  • 90.1 (n)
  • 96.24 (a)
Pparg 16
Pparg 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPARG 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPARG 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pparg 35
  • 89.83 (n)
  • 95.84 (a)
chicken
(Gallus gallus)
Aves PPARG 35
  • 82.25 (n)
  • 92.84 (a)
PPARG 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPARG 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia PPARg 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16633 35
zebrafish
(Danio rerio)
Actinopterygii pparg 35
  • 67.02 (n)
  • 69.34 (a)
pparg 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eip75B 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea sex-1 37
  • 27 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.186 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for PPARG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPARG Gene

ENSEMBL:
Gene Tree for PPARG (if available)
TreeFam:
Gene Tree for PPARG (if available)

Paralogs for PPARG Gene

genes like me logo Genes that share paralogs with PPARG: view

Variants for PPARG Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PPARG Gene

P37231-PPARG_HUMAN
Genetic variation in PPARG may influence body mass index (BMI) [MIM:606641]. BMI reflects the amount of fat, lean mass, and body build

Sequence variations from dbSNP and Humsavar for PPARG Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs709147 -- 12,407,441(-) GCTCA(C/T)GCCTG intron-variant
rs709148 -- 12,408,667(-) AGGAC(G/T)GCTTG intron-variant
rs709149 -- 12,408,855(-) ACCAC(C/T)GAGGC intron-variant
rs709150 -- 12,409,838(-) GGCAG(C/G)GCGCA intron-variant
rs709151 -- 12,413,500(-) TTTCT(A/G)CATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPARG Gene

Variant ID Type Subtype PubMed ID
dgv810e201 CNV Deletion 23290073
dgv850e199 CNV Deletion 23128226
nsv7351 OTHER Inversion 18451855
nsv3702 CNV Loss 18451855
esv4138 CNV Deletion 18987735
esv2724933 CNV Deletion 23290073
esv7808 CNV Loss 19470904
esv2669014 CNV Deletion 23128226
esv2661678 CNV Deletion 23128226

Relevant External Links for PPARG Gene

HapMap Linkage Disequilibrium report
PPARG
Human Gene Mutation Database (HGMD)
PPARG

Disorders for PPARG Gene

(4) OMIM Diseases for PPARG Gene (601487)

UniProtKB/Swiss-Prot

PPARG_HUMAN
  • Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer.
  • Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269 PubMed:9753710}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.
  • Lipodystrophy, familial partial, 3 (FPLD3) [MIM:604367]: A form of lipodystrophy characterized by marked loss of subcutaneous fat from the extremities. Facial adipose tissue may be increased, decreased or normal. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia. {ECO:0000269 PubMed:11788685, ECO:0000269 PubMed:12453919}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Glioma 1 (GLM1) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.

(95) Novoseek inferred disease relationships for PPARG Gene

Disease -log(P) Hits PubMed IDs
insulin sensitivity 86.4 125
insulin resistance 86.2 162
obesity 76.9 136
niddm 75.3 107
atherosclerosis 73.2 115

Genatlas disease for PPARG Gene

marked obesity with a high body-mass index and a defect in the regulation of adipocyte differentiation associated with type 2 diabetes

Relevant External Links for PPARG

Genetic Association Database (GAD)
PPARG
Human Genome Epidemiology (HuGE) Navigator
PPARG
genes like me logo Genes that share disorders with PPARG: view

Publications for PPARG Gene

  1. Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma. (PMID: 9813012) Uppenberg J. … Berkenstam A. (J. Biol. Chem. 1998) 3 4 23
  2. Loss-of-function mutations in PPAR-gamma associated with human colon cancer. (PMID: 10394368) Sarraf P. … Eng C. (Mol. Cell 1999) 3 4 23
  3. Dominant negative mutations in human PPAR-gamma associated with severe insulin resistance, diabetes mellitus and hypertension. (PMID: 10622252) Barroso I. … O'Rahilly S. (Nature 1999) 3 4 23
  4. Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. (PMID: 10882139) Gampe R.T. Jr. … Xu H.E. (Mol. Cell 2000) 3 4 23
  5. The role of PPARgamma as a thrifty gene both in mice and humans. (PMID: 11242476) Hara K. … Kadowaki T. (Br. J. Nutr. 2000) 3 23 48

Products for PPARG Gene

  • Addgene plasmids for PPARG

Sources for PPARG Gene

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