Aliases for PPARD Gene
External Ids for PPARD Gene
Previous GeneCards Identifiers for PPARD Gene
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
GeneCards Summary for PPARD Gene
PPARD (Peroxisome Proliferator-Activated Receptor Delta) is a Protein Coding gene. Diseases associated with PPARD include diabetic cataract and atherosclerosis. Among its related pathways are Pathways in cancer and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and lipid binding. An important paralog of this gene is NR1I2.
UniProtKB/Swiss-Prot for PPARD Gene
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
Peroxisome proliferator-activated receptor delta (PPARdelta), also known as PPARbeta, is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression. PPARdelta display a ubiquitous expression pattern and is thought to regulate placental and gut development, fatty acid oxidation, adaptive thermogenesis, control of cell proliferation and differentiation and tissue repair. The human gene encoding PPARdelta has been localized to chromosome 6 (6p21.2).