Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPARD Gene

Aliases for PPARD Gene

  • Peroxisome Proliferator-Activated Receptor Delta 2 3
  • NUC1 3 4 6
  • Peroxisome Proliferator-Activated Receptor Beta 3 4
  • Nuclear Receptor Subfamily 1 Group C Member 2 3 4
  • Nuclear Hormone Receptor 1 3 4
  • PPAR-Delta 3 4
  • PPAR-Beta 3 4
  • NR1C2 3 4
  • PPARB 3 4
  • NUCI 3 4
  • Peroxisome Proliferator-Activated Nuclear Receptor Beta/Delta Variant 2 3
  • Peroxisome Proliferative Activated Receptor, Delta 2
  • NUCII 3
  • FAAR 3

External Ids for PPARD Gene

Summaries for PPARD Gene

Entrez Gene Summary for PPARD Gene

  • This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

GeneCards Summary for PPARD Gene

PPARD (Peroxisome Proliferator-Activated Receptor Delta) is a Protein Coding gene. Diseases associated with PPARD include diabetic cataract and atherosclerosis. Among its related pathways are Pathways in cancer and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and lipid binding. An important paralog of this gene is NR1I2.

UniProtKB/Swiss-Prot for PPARD Gene

  • Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.

Tocris Summary for PPARD Gene

  • Peroxisome proliferator-activated receptor delta (PPARdelta), also known as PPARbeta, is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression. PPARdelta display a ubiquitous expression pattern and is thought to regulate placental and gut development, fatty acid oxidation, adaptive thermogenesis, control of cell proliferation and differentiation and tissue repair. The human gene encoding PPARdelta has been localized to chromosome 6 (6p21.2).

Gene Wiki entry for PPARD Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPARD Gene

Genomics for PPARD Gene

Genomic Location for PPARD Gene

Start:
35,342,558 bp from pter
End:
35,428,191 bp from pter
Size:
85,634 bases
Orientation:
Plus strand

Genomic View for PPARD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPARD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPARD Gene

Regulatory Elements for PPARD Gene

Proteins for PPARD Gene

  • Protein details for PPARD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03181-PPARD_HUMAN
    Recommended name:
    Peroxisome proliferator-activated receptor delta
    Protein Accession:
    Q03181
    Secondary Accessions:
    • A8K6J6
    • B4E3V3
    • B6ZGS1
    • B7Z3W1
    • E9PE18
    • Q5D1P0
    • Q7Z5K0
    • Q9BUD4

    Protein attributes for PPARD Gene

    Size:
    441 amino acids
    Molecular mass:
    49903 Da
    Quaternary structure:
    • Heterodimer with the retinoid X receptor.

    Three dimensional structures from OCA and Proteopedia for PPARD Gene

    Alternative splice isoforms for PPARD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPARD Gene

Proteomics data for PPARD Gene at MOPED

Post-translational modifications for PPARD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPARD Gene

No data available for DME Specific Peptides for PPARD Gene

Domains for PPARD Gene

Gene Families for PPARD Gene

Graphical View of Domain Structure for InterPro Entry

Q03181

UniProtKB/Swiss-Prot:

PPARD_HUMAN
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.:
    • Q03181
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.:
    • Q03181
genes like me logo Genes that share domains with PPARD: view

Function for PPARD Gene

Molecular function for PPARD Gene

GENATLAS Biochemistry: Peroxisome proliferator-activated receptor delta,heterodimerizing with RXR*,steroid/thyroid hormone receptor superfamily,expressed in preadipocyte and expressed at low level in colorectal mucosa,highly expressed in CR carcinomal,down- regulated by APC through beta-catenin/TCF4 inactivation,target of nonsteroidal inflammatory drugs
UniProtKB/Swiss-Prot Function: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.

Gene Ontology (GO) - Molecular Function for PPARD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 11551955
GO:0003707 steroid hormone receptor activity IEA --
GO:0003713 transcription coactivator activity IEA --
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IDA 12955147
genes like me logo Genes that share ontologies with PPARD: view
genes like me logo Genes that share phenotypes with PPARD: view

Animal Models for PPARD Gene

MGI Knock Outs for PPARD:

miRNA for PPARD Gene

miRTarBase miRNAs that target PPARD

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PPARD Gene

Localization for PPARD Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPARD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPARD Gene COMPARTMENTS Subcellular localization image for PPARD gene
Compartment Confidence
nucleus 5
peroxisome 4
extracellular 1

Gene Ontology (GO) - Cellular Components for PPARD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 11551955
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PPARD: view

Pathways for PPARD Gene

genes like me logo Genes that share pathways with PPARD: view

Pathways by source for PPARD Gene

Gene Ontology (GO) - Biological Process for PPARD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001890 placenta development --
GO:0006006 glucose metabolic process NAS 15793256
GO:0006029 proteoglycan metabolic process IEA --
GO:0006091 generation of precursor metabolites and energy TAS 1333051
genes like me logo Genes that share ontologies with PPARD: view

Compounds for PPARD Gene

(4) Tocris Compounds for PPARD Gene

Compound Action Cas Number
GSK 0660 Selective PPARdelta antagonist [1014691-61-2]
GSK 3787 Potent and selective PPARdelta antagonist [188591-46-0]
GW 0742 Highly selective, potent PPARdelta agonist [317318-84-6]
L-165,041 Potent PPARdelta agonist [79558-09-1]

(32) HMDB Compounds for PPARD Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(9) IUPHAR Ligand for PPARD Gene

Ligand Type Action Affinity Pubmed IDs
all-trans-retinoic acid Agonist Agonist 9.4
GW0742X Agonist Full agonist 9
GW501516 Agonist Full agonist 8.96
L-796449 Agonist Full agonist 8.7
L-165041 Agonist Full agonist 8.22
L-783483 Agonist Agonist 8.2
GW2433 Agonist Full agonist 6.57
GSK0660 Antagonist Antagonist 6.52
GW9578 Agonist Full agonist 5.9

(64) Novoseek inferred chemical compound relationships for PPARD Gene

Compound -log(P) Hits PubMed IDs
gw501516 97.6 56
gw 0742 93.1 13
gw2433 83 2
carbacyclin 75.8 2
rosiglitazone 74.1 10

(2) PharmGKB related drug/compound annotations for PPARD Gene

Drug/compound Annotation
docetaxel CA
thalidomide CA
genes like me logo Genes that share compounds with PPARD: view

Transcripts for PPARD Gene

Unigene Clusters for PPARD Gene

Peroxisome proliferator-activated receptor delta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPARD Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - - - - - - -
SP12: - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - -
SP14: - - - - -
SP15: -
SP16:

ExUns: 15c · 15d ^ 16a · 16b ^ 17a · 17b
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for PPARD Gene

GeneLoc Exon Structure for
PPARD
ECgene alternative splicing isoforms for
PPARD

Expression for PPARD Gene

mRNA expression in normal human tissues for PPARD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PPARD Gene

SOURCE GeneReport for Unigene cluster for PPARD Gene Hs.696032

mRNA Expression by UniProt/SwissProt for PPARD Gene

Q03181-PPARD_HUMAN
Tissue specificity: Ubiquitous with maximal levels in placenta and skeletal muscle
genes like me logo Genes that share expressions with PPARD: view

No data available for mRNA differential expression in normal tissues for PPARD Gene

Orthologs for PPARD Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPARD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPARD 35
  • 99.32 (n)
  • 99.77 (a)
PPARD 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPARD 35
  • 91.93 (n)
  • 96.13 (a)
PPARD 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPARD 35
  • 91.69 (n)
  • 95.92 (a)
PPARD 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppard 35
  • 89.51 (n)
  • 93.22 (a)
Ppard 16
Ppard 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPARD 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPARD 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppard 35
  • 88.78 (n)
  • 92.25 (a)
chicken
(Gallus gallus)
Aves PPARD 35
  • 83.05 (n)
  • 88.56 (a)
PPARD 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPARD 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppard 35
  • 69 (n)
  • 71.16 (a)
Str.16577 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12140 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
pparda 36
  • 64 (a)
OneToMany
ppardb 35
  • 74.45 (n)
  • 81.89 (a)
ppardb 36
  • 63 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for PPARD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPARD Gene

ENSEMBL:
Gene Tree for PPARD (if available)
TreeFam:
Gene Tree for PPARD (if available)

Paralogs for PPARD Gene

Selected SIMAP similar genes for PPARD Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PPARD: view

Variants for PPARD Gene

Sequence variations from dbSNP and Humsavar for PPARD Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs9794 -- 35,428,018(+) GCCCC(A/C/G)ACCCG utr-variant-3-prime
rs745308 -- 35,428,624(-) CACTG(C/G)AAACA downstream-variant-500B
rs760783 -- 35,428,227(-) CCTGT(A/C)AGCCC downstream-variant-500B
rs1003973 -- 35,409,524(+) aacaa(A/C)aaaaa intron-variant
rs1040436 -- 35,400,132(-) GAGAC(C/T)TCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPARD Gene

Variant ID Type Subtype PubMed ID
nsv830641 CNV Loss 17160897
nsv885798 CNV Loss 21882294
esv2661487 CNV Deletion 23128226
nsv462907 CNV Loss 19166990
nsv470812 CNV Loss 18288195
nsv528351 CNV Loss 19592680
nsv885799 CNV Loss 21882294
nsv519370 CNV Loss 19592680
nsv885800 CNV Loss 21882294

Relevant External Links for PPARD Gene

HapMap Linkage Disequilibrium report
PPARD
Human Gene Mutation Database (HGMD)
PPARD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPARD Gene

Disorders for PPARD Gene

(1) University of Copenhagen DISEASES for PPARD Gene

(42) Novoseek inferred disease relationships for PPARD Gene

Disease -log(P) Hits PubMed IDs
insulin sensitivity 67.1 18
dyslipidemia 63.6 12
metabolic disorder 60.3 12
insulin resistance 56.4 19
obesity 49.9 27

Relevant External Links for PPARD

Genetic Association Database (GAD)
PPARD
Human Genome Epidemiology (HuGE) Navigator
PPARD
genes like me logo Genes that share disorders with PPARD: view

No data available for UniProtKB/Swiss-Prot for PPARD Gene

Publications for PPARD Gene

  1. Molecular recognition of fatty acids by peroxisome proliferator- activated receptors. (PMID: 10198642) Xu H.E. … Milburn M.V. (Mol. Cell 1999) 3 4 23 25
  2. Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men. (PMID: 14641801) Skogsberg J. … Ehrenborg E. (J. Intern. Med. 2003) 3 23 48
  3. Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity. (PMID: 14988273) Shin H.D. … Park K.S. (Diabetes 2004) 3 23 48
  4. No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARdelta and PPARgamma act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma. (PMID: 16141797) McGreavey L.E. … Barrett J.H. (Pharmacogenet. Genomics 2005) 3 23 48
  5. [PPARdelta + 294T/C gene polymorphism related to plasma lipid, obesity and left ventricular hypertrophy in subjects with metabolic syndrome]. (PMID: 16053787) Yan Z.C. … Zhu Z.M. (Zhonghua Xin Xue Guan Bing Za Zhi 2005) 3 23 48

Products for PPARD Gene

  • Addgene plasmids for PPARD

Sources for PPARD Gene

Back to Top

Content