Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPARA Gene

protein-coding   GIFtS: 73
GCID: GC22P046546

Peroxisome Proliferator-Activated Receptor Alpha

(Previous names: peroxisome proliferative activated receptor, alpha)
(Previous symbol: PPAR)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peroxisome Proliferator-Activated Receptor Alpha1 2     PPAR-alpha2 3
PPAR1 2 3 5     PPARalpha2
Peroxisome Proliferative Activated Receptor, Alpha1 2     hPPAR2
Nuclear Receptor Subfamily 1 Group C Member 12 3     Peroxisome Proliferator-Activated Nuclear Receptor Alpha Variant 32
NR1C12 3     

External Ids:    HGNC: 92321   Entrez Gene: 54652   Ensembl: ENSG000001869517   OMIM: 1709985   UniProtKB: Q078693   

Export aliases for PPARA gene to outside databases

Previous GC identifers: GC22P043114 GC22P044760 GC22P044868 GC22P044954 GC22P029490


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PPARA Gene:
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this
term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular
organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid
metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called
PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes
involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely
related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha,
which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described
for this gene, although the full-length nature of only two has been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for PPARA Gene: 
PPARA (peroxisome proliferator-activated receptor alpha) is a protein-coding gene. Diseases associated with PPARA include tularemia, and hypertensive heart disease, and among its related super-pathways are Nuclear Receptors and Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein domain specific binding. An important paralog of this gene is RORC.

UniProtKB/Swiss-Prot: PPARA_HUMAN, Q07869
Function: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous
ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a
naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as
hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions
as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization
with RXRA and is antagonized by NR2C2

summary for PPARA Gene:
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a member of the nuclear receptor family of
ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate
gene expression. PPARalpha is located primarily in the liver, adipose tissue, kidney, heart, skeletal muscle
and large intestine where it is thought to regulate fatty acid synthesis and oxidation, gluconeogenesis,
ketogenesis and lipoprotein assembly. The human gene encoding PPARalpha has been localized to chromosome 22
(22q12-13.1).

Gene Wiki entry for PPARA (Peroxisome proliferator-activated receptor alpha) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPARA gene promoter:
         AP-2alpha isoform 3   AP-1   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PPARA promoter sequence
   Search SABiosciences Chromatin IP Primers for PPARA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPARA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31   Ensembl cytogenetic band:  22q13.31   HGNC cytogenetic band: 22q12-q13.1

PPARA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPARA gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P046546:  view genomic region     (about GC identifiers)

Start:
46,546,424 bp from pter      End:
46,639,653 bp from pter
Size:
93,230 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PPARA_HUMAN, Q07869 (See protein sequence)
Recommended Name: Peroxisome proliferator-activated receptor alpha  
Size: 468 amino acids; 52225 Da
Subunit: Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity.
Interacts with AKAP13, LPIN1 and PRDM16. Also interacts with PPARBP coactivator in vitro. Interacts with CITED2;
the interaction stimulates its transcriptional activity (By similarity). Interacts with NCOA3 and NCOA6
coactivators. Interacts with ASXL1 AND ASXL2
Subcellular location: Nucleus
6/15 PDB 3D structures from and Proteopedia for PPARA (see all 15):
1I7G (3D)        1K7L (3D)        1KKQ (3D)        2NPA (3D)        2P54 (3D)        2REW (3D)    
Secondary accessions: B0G0X3 Q16241 Q6I9S0 Q92486 Q92689 Q9Y3N1
Alternative splicing: 2 isoforms:  Q07869-1   Q07869-2   

Explore the universe of human proteins at neXtProt for PPARA: NX_Q07869

Explore proteomics data for PPARA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q07869

  • PPARA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PPARA Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001001928.1  NP_005027.2  

    ENSEMBL proteins: 
     ENSP00000397291   ENSP00000411677   ENSP00000414752   ENSP00000385523   ENSP00000385246  
     ENSP00000379322   ENSP00000262735   ENSP00000408149  
    Reactome Protein details: Q07869
    Human Recombinant Protein Products for PPARA: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PPARA
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PPARA
    GenScript Custom Purified and Recombinant Proteins Services for PPARA
    Novus Biologicals PPARA Protein
    Novus Biologicals PPARA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS16271724
    GO:0005654nucleoplasm TAS--

    PPARA for ontologies           About GeneDecksing



    PPARA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PPARA
    R&D Systems Antibodies for PPARA (PPAR alpha/NR1C1)
    OriGene Antibodies for PPARA
    OriGene Custom Antibody Services for PPARA
    GenScript Superior Antibodies for PPARA
    Novus Biologicals PPARA Antibodies
    Abcam antibodies for PPARA
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for PPARA
    LSBio Antibodies in human, mouse, rat for PPARA 

    Assay Products for PPARA: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PPARA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PPARA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Peroxisome proliferator-activated receptor-&alpha 
    1C. Peroxisome proliferator-activated receptors

    5/7 InterPro protein domains (see all 7):
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR001723 Str_hrmn_rcpt
     IPR003074 1Cnucl_rcpt
     IPR013088 Znf_NHR/GATA
     IPR003076 1Cnucl_rcpt_A

    Graphical View of Domain Structure for InterPro Entry Q07869

    ProtoNet protein and cluster: Q07869

    3 Blocks protein domains:
    IPB001723 Steroid hormone receptor signature
    IPB003074 Peroxisome proliferator-activated receptor (1C nuclear receptor) signature
    IPB003076 Peroxisome proliferator-activated receptor alpha signature


    UniProtKB/Swiss-Prot: PPARA_HUMAN, Q07869
    Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    PPARA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPARA_HUMAN, Q07869
    Function: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous
    ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a
    naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as
    hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions
    as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization
    with RXRA and is antagonized by NR2C2

         Genatlas biochemistry entry for PPARA:
    peroxisome proliferator-activated receptor,alpha isoform,steroid/thyroid hormone receptor
    superfamily,heterodimerizing with RXR*,highly expressed in liver,involved in the control of fatty acid
    synthesis,oxidation and ketogenesis,plyaing a critical role in the cellular fasting response

         Gene Ontology (GO): 5/17 molecular function terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001103RNA polymerase II repressing transcription factor binding IPI19955185
    GO:0003677DNA binding TAS10860941
    GO:0003700sequence-specific DNA binding transcription factor activity ISS--
    GO:0003707steroid hormone receptor activity IDA19955185
    GO:0004872receptor activity ----
         
    PPARA for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PPARA:
     Decreased cell number  Decreased influenza A virus in 

         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ppara):
     adipose tissue  cardiovascular system  cellular  growth/size  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  muscle 

    PPARA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pparatm1Gonz for PPARA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PPARA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPARA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PPARA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PPARA 

    10/612 SABiosciences Target genes for PPARA (see all 612):
    A2ML1 ABCG8 ABHD14B ABRA ABTB2 ACMSD ACOT1 ACOT4 ACOT6 ACOT8

    miRNA
    Products:
        
    miRTarBase miRNAs that target PPARA:
    hsa-mir-22 (MIRT002473), hsa-mir-519d (MIRT000630), hsa-mir-10b (MIRT005068)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPARA
    8/109 QIAGEN miScript miRNA Assays for microRNAs that regulate PPARA (see all 109):
    hsa-miR-520e hsa-miR-106a hsa-miR-200a hsa-miR-128 hsa-miR-219-5p hsa-miR-550a* hsa-miR-409-5p hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidPPARA 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PPARA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPARA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PPARA
    Sirion Biotech Customized adenovirus for overexpression of PPARA

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PPARA (see all 15)
    OriGene ORF clones in mouse, rat for PPARA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PPARA (NM_005036)
    Sino Biological Human cDNA Clone for PPARA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPARA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPARA
    Sirion Biotech Customized lentivirus for stable overexpression of PPARA 
                         Customized lentivirus expression plasmids for stable overexpression of PPARA 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PPARA
    Search LifeMap BioReagents cell lines for PPARA
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPARA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PPARA About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.68
    Nuclear Receptors0.68
    2Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.74
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    PPARA Activates Gene Expression0.74
    3Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    4Circadian Clock
    Circadian Clock0.40
    BMAL1:CLOCK/NPAS2 Activates Circadian Expression0.40
    5Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for PPARA
        Transcription PPAR Pathway
    Transcription Sin3 and NuRD in transcription regulation

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPARA
        PGC1Alpha Pathway
    PPAR Pathway

    2 GeneGo (Thomson Reuters) Pathways for PPARA
        Transcription Sin3 and NuRD in transcription regulation
    Transcription PPAR Pathway

    5 BioSystems Pathways for PPARA
        Adipogenesis
    Nuclear Receptors
    SREBF and miR33 in cholesterol and lipid homeostasis
    Nuclear receptors in lipid metabolism and toxicity
    Energy Metabolism


    5/10        Reactome Pathways for PPARA (see all 10)
        Circadian Clock
    Generic Transcription Pathway
    Nuclear Receptor transcription pathway
    Metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism


    4         Kegg Pathways  (Kegg details for PPARA):
        PPAR signaling pathway
    Adipocytokine signaling pathway
    Non-alcoholic fatty liver disease (NAFLD)
    Hepatitis C


    PPARA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PPARA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/175 Interacting proteins for PPARA (Q078691, 2, 3 ENSP000002627354) via UniProtKB, MINT, STRING, and/or I2D (see all 175)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCOR2Q9Y6182, 3, ENSP000003485514MINT-15842 MINT-15843 I2D: score=3 STRING: ENSP00000348551
    FABP1P071483, ENSP000002958344I2D: score=2 STRING: ENSP00000295834
    MED1Q156483, ENSP000003006514I2D: score=2 STRING: ENSP00000300651
    PPARGC1AQ9UBK23, ENSP000002648674I2D: score=2 STRING: ENSP00000264867
    DUTP333163, ENSP000003703764I2D: score=1 STRING: ENSP00000370376
    About this table

    Gene Ontology (GO): 5/38 biological process terms (GO ID links to tree view) (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA12700342
    GO:0001666response to hypoxia IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006629lipid metabolic process TAS7684926

    PPARA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPARA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for PPARA

    Compounds for PPARA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CP 775146 Selective, high affinity PPARalpha agonist [702680-17-9]
    WY 14643Selective PPARalpha agonist[50892-23-4]
    GW 7647 Highly selective, potent PPARalpha agonist. Orally active [265129-71-3]
    GW 6471PPARalpha antagonist[880635-03-0]
    PalmitoylethanolamideSelective GPR55 agonist. FAAH and PAA substrate[544-31-0]

    10/34 HMDB Compounds for PPARA (see all 34)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    8 DrugBank Compounds for PPARA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    BezafibrateBezafibrat (see all 3)41859-67-0targetagonist11519881 10909982 11422732 11752352 11172467 10933891 18629356 16511610
    ClofibrateChlorfenisate (see all 11)637-07-0targetagonist20637823 20671072 10753628 10454501 10922459 10951268 10787442
    FenofibrateFenofibrato [INN-Spanish] (see all 5)49562-28-9targetagonist11018525 10799317 10828060 11752352 11474486 10494028 11342537
    Gemfibrozil-- 25812-30-0targetagonist12244038 12172398 12834305 12935323 10494028
    ALEGLITAZAR R-1439 (see all 2)475479-34-6targetagonist20653327 10592235
    Deoxy-Bigchap-- --target--17139284 17016423
    2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID-- --target--10592235
    3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid-- --target--10592235

    10/25 IUPHAR Ligands for PPARA (Peroxisome proliferator-activated receptor-&alpha) (see all 25)    About this table 
    LigandTypeActionAffinityPubmed IDs
    GW409544
    Agonist8.711698662 15293980
    GW7647
    AgonistAgonist8.2210389847 11354382
    MK-0767
    AgonistAgonist6.8 - 7.6410403814 15120604 9836514
    TZD18
    AgonistAgonist7.614701675
    LY-518674
    AgonistAgonist7.614613314
    LY-510929
    AgonistAgonist7.5515115385
    GW9578
    AgonistAgonist7.310389847 10508427 11354382
    imiglitazar
    AgonistAgonist7.1711095972
    8S-HETE
    AgonistAgonist77592593 9113986
    oleoylethanolamide
    AgonistAgonist6.9212955147 15910890

    10/141 Novoseek inferred chemical compound relationships for PPARA gene (see all 141)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fenofibrate 92.5 208 15618549 (4), 17184146 (4), 20511708 (3), 19150877 (3) (see all 99)
    wy14643 92.1 103 17610302 (4), 10744771 (3), 15183193 (2), 12191966 (2) (see all 65)
    rosiglitazone 87.5 76 19067734 (2), 10393202 (2), 15821150 (2), 18985998 (2) (see all 61)
    ciglitazone 86.6 28 12191966 (2), 12195700 (2), 12352144 (1), 12860474 (1) (see all 24)
    15-deoxy-delta-12,14-prostaglandin j2 85.9 37 11840453 (2), 11971025 (1), 12860474 (1), 19429239 (1) (see all 24)
    gw 7647 85.4 26 20110263 (4), 11354382 (2), 19887568 (2), 17683485 (1) (see all 14)
    ragaglitazar 85 15 16240504 (3), 14551179 (2), 17014868 (2), 16822823 (2) (see all 9)
    fenofibric acid 84.9 24 15169608 (1), 17533223 (1), 15201343 (1), 19661212 (1) (see all 15)
    gw501516 84.3 8 17461989 (1), 16038868 (1), 19667161 (1), 15612696 (1) (see all 7)
    fatty acid 83.6 352 11071880 (3), 17007889 (3), 15614817 (3), 18460914 (3) (see all 99)

    2 PharmGKB related drug/compound annotations for PPARA gene    About this table
    Drug/compound PharmGKB Annotation
    Beta Blocking AgentsCA  
    fenofibrateCA  

    Search CenterWatch for drugs/clinical trials and news about PPARA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PPARA gene (5 alternative transcripts): 
    NM_001001928.2  NM_005036.4  NM_001001929.2  NM_001001930.2  NM_032644.3  

    Unigene Clusters for PPARA:

    Peroxisome proliferator-activated receptor alpha
    Hs.103110  [show with all ESTs], Hs.710044  [show with all ESTs]
    Unigene Representative Sequences: NM_005036, BX091396
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000440343 ENST00000415785 ENST00000420804 ENST00000460086 ENST00000407236(uc003bgw.1 uc010hab.1 uc003bhb.1)
    ENST00000496865 ENST00000484619(uc003bgy.1) ENST00000481567(uc003bgz.1)
    ENST00000402126 ENST00000493286(uc003bha.3) ENST00000396000 ENST00000262735(uc003bgx.1 uc010hac.1)
    ENST00000434345

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPARA
    8/109 QIAGEN miScript miRNA Assays for microRNAs that regulate PPARA (see all 109):
    hsa-miR-520e hsa-miR-106a hsa-miR-200a hsa-miR-128 hsa-miR-219-5p hsa-miR-550a* hsa-miR-409-5p hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidPPARA 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PPARA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPARA
    Clone
    Products:
         
    OriGene clones in human, mouse for PPARA (see all 15)
    OriGene ORF clones in mouse, rat for PPARA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PPARA (NM_005036)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PPARA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPARA
    Sirion Biotech Customized lentivirus for stable overexpression of PPARA 
                         Customized lentivirus expression plasmids for stable overexpression of PPARA 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PPARA
    OriGene qSTAR qPCR primer pairs in human, mouse for PPARA
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPARA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPARA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPARA

    Additional mRNA sequence: AF086231.1 

    11 DOTS entries:

    DT.407609  DT.75189634  DT.75100475  DT.204727  DT.70104478  DT.100755573  DT.120629902  DT.100743056 
    DT.315850  DT.91712491  DT.95368145 

    24/200 AceView cDNA sequences (see all 200):

    AA587942 BM996338 AI679311 CA429857 BX113616 CA442597 AA702773 NM_032644 
    AA352097 BC000052 CA395302 BC004162 BU619290 AF270490 BU584566 BU622522 
    BM550114 AI753669 S74349 AI828429 AI633755 AY258328 AI911455 NM_001001929 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PPARA (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b
    SP1:                                      -                       -                             -                     
    SP2:                                      -                       -                             -                     
    SP3:                                                              -                                                   
    SP4:                          -     -     -                       -                                                   
    SP5:                          -     -     -                       -                                                   


    ECgene alternative splicing isoforms for PPARA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPARA expression in normal human tissues (normalized intensities)      PPARA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGTTAGAT
    PPARA Expression
    About this image


    PPARA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 7 entries
             Lumbar Brown Adipocyte Cells Lumbar Brown Adipose Depot
             Thoracic Perivascular Adipose
             Brown adipocyte-like cells ( Directed differentiation of human pluripotent stem cells...
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Intermediate Keratinocytes Embryonic Epidermis
     
     Blood Brain Barrier (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier

    See PPARA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPARA

    SOURCE GeneReport for Unigene clusters: Hs.103110 Hs.710044

    UniProtKB/Swiss-Prot: PPARA_HUMAN, Q07869
    Tissue specificity: Skeletal muscle, liver, heart and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including PPARA (see all 15): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Hepatotoxicity in human mouse rat
              Diabetes in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PPARA
    OriGene qSTAR qPCR primer pairs in human, mouse for PPARA
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PPARA
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPARA
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPARA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPARA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PPARA gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppara1 , 5 peroxisome proliferator activated receptor alpha1, 5 85.54(n)1
    92.31(a)1
      15 (40.42 cM)5
    190131  NM_001113418.11  NP_001106889.11 
     857349835 
    chicken
    (Gallus gallus)
    Aves PPARA1 peroxisome proliferator-activated receptor alpha 79.2(n)
    88.89(a)
      374120  NM_001001464.1  NP_001001464.1 
    lizard
    (Anolis carolinensis)
    Reptilia PPARA6
    Uncharacterized protein
    84(a)
    1 ↔ 1
    5(83451781-83461047)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685372 hypothetical protein MGC68537 75.58(n)    M84161.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005348181 peroxisome proliferator-activated receptor alpha-like 72.42(n)
    79.44(a)
      100534818  XM_003201374.1  XP_003201422.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eip75B6
    Ecdysone-induced protein 75B
    10(a)
    1 → many
    3L(17944053-18057796)


    ENSEMBL Gene Tree for PPARA (if available)
    TreeFam Gene Tree for PPARA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPARA gene
    RORC2  NR1D22  PPARD2  RORA2  NR1D12  RORB2  PPARG2  
    13 SIMAP similar genes for PPARA using alignment to 5 protein entries:     PPARA_HUMAN (see all proteins):
    NR1C1    PPARD    NR1C2    HNF4G    NR1C3    PPARG
    VDR    NR1B2    NR1B3    RARB    RARG    RARA
    PML-RAR

    PPARA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2186 SNPs in PPARA are shown (see all 2186)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18002061,2,4
    C,F,Hother130531127(+) AGTGCC/GTTTCT 4 L V mis119Minor allele frequency- G:0.04NS MN EA NA EU 7580
    rs96267091,2
    C,F--30461399(+) CCCCCG/AGGAAG 2 -- us2k13Minor allele frequency- A:0.24WA CSA 122
    rs738867511,2
    C,F--30461403(+) CGGGAG/AGCATG 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1419051691,2
    --30461555(+) TTTCTC/TTCCCT 2 -- us2k10--------
    rs1472397901,2
    --30461584(+) AAAAAC/TCCAAG 2 -- us2k10--------
    rs1916080521,2
    --30461613(+) CTGCTA/GAGTGT 2 -- us2k10--------
    rs1390737511,2
    --30461620(+) GTGTAC/GGTGAC 2 -- us2k10--------
    rs1428839611,2
    --30461751(+) TGAGAG/TTCTGG 2 -- us2k10--------
    rs57673201,2
    C--30461754(+) GAGTCT/AGGGAT 2 -- us2k1 tfbs34Minor allele frequency- A:0.12NA WA EA 360
    rs1839088021,2
    --30461790(+) AGCCCA/GGAGGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPARA (46546424 - 46639653 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for PPARA (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667871CNV Deletion23128226
    dgv5012n71CNV Loss21882294
    nsv834224CNV Loss17160897
    dgv5008n71CNV Loss21882294
    nsv915340CNV Loss21882294
    nsv915336CNV Loss21882294
    dgv5006n71CNV Loss21882294
    dgv5013n71CNV Loss21882294
    nsv191496CNV Loss16902084
    nsv915346CNV Loss21882294


    Human Gene Mutation Database (HGMD): PPARA
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PPARA
    DNA2.0 Custom Variant and Variant Library Synthesis for PPARA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 170998    OMIM disorders: --

    20/127 diseases for PPARA (see all 127):    About MalaCards
    tularemia    hypertensive heart disease    alcoholic cardiomyopathy    carbohydrate metabolic disorder
    autoimmune myocarditis    tangier disease    hypoalphalipoproteinemias    familial hyperlipidemia
    acne    fatty acid oxidation disorders    metabolic disorders    hepatoblastoma
    liver disease    nonalcoholic steatohepatitis    batten disease    fatty liver disease
    glucose intolerance    familial combined hyperlipidemia    adrenoleukodystrophy    myocarditis

    6 diseases from the University of Copenhagen DISEASES database for PPARA:
    Diabetes mellitus     Atherosclerosis     Fatty liver disease     Hyperglycemia
    Hypertension     Heart disease

    PPARA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for PPARA gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dyslipidemia 79.9 86 19454308 (2), 17896982 (2), 16101410 (2), 10327283 (1) (see all 66)
    insulin resistance 77.1 77 16731822 (3), 16868225 (3), 18212024 (3), 17611904 (3) (see all 57)
    insulin sensitivity 74.7 69 17184146 (4), 15910175 (4), 14519597 (3), 17904198 (3) (see all 39)
    atherosclerosis 73.8 127 17631413 (6), 11914252 (3), 10327283 (2), 16503871 (2) (see all 87)
    fatty liver 71.4 33 16762007 (2), 17022944 (2), 15118095 (1), 15382158 (1) (see all 21)
    metabolic disorder 69.8 41 18566691 (3), 14683520 (2), 10327283 (1), 15283041 (1) (see all 28)
    obesity 69.2 79 19646654 (3), 19700678 (2), 14704738 (2), 11590995 (2) (see all 57)
    inflammation 68 211 17935055 (3), 17981503 (3), 16091136 (3), 10327283 (2) (see all 99)
    cardiovascular diseases 63.2 67 18034623 (3), 18288280 (2), 15503647 (2), 16316298 (2) (see all 49)
    hypertriglyceridemia 60.3 16 16497336 (1), 20021445 (1), 9209702 (1), 15828840 (1) (see all 16)

    Genetic Association Database (GAD): PPARA
    Human Genome Epidemiology (HuGE) Navigator: PPARA (125 documents)

    Export disorders for PPARA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPARA gene, integrated from 9 sources (see all 1837):
    (articles sorted by number of sources associating them with PPARA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
    2. cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. (PubMed id 7684926)1, 2, 3 Sher T.... Gonzales F.J. (1993)
    3. Optimization of an enzyme-linked immunosorbent assay to screen ligand of Peroxisome proliferator-activated receptor alpha. (PubMed id 19263263)1, 2, 9 Cho M.-C....Yoon D.-Y. (2009)
    4. Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family. (PubMed id 11587644)1, 2, 9 Cronet P.... Bamberg K. (2001)
    5. Interaction between PPARA genotype and beta-blocker treatment influences clinical outcomes following acute coronary syndromes. (PubMed id 18855529)1, 4, 9 Cresci S....Spertus J.A. (2008)
    6. Peroxisome proliferator-activated receptor-alpha (PPARA) genetic polymorphisms and breast cancer risk: a Long Island ancillary study. (PubMed id 18586686)1, 4, 9 Golembesky A.K....Santella R.M. (2008)
    7. Mutation screening of the PPARalpha gene in type 2 diabetes associated with coronary heart disease. (PubMed id 11119019)1, 4, 9 Lacquemant C....Froguel P. (2000)
    8. Peroxisome proliferator-activated receptor [alpha] genetic variation interacts with n-6 and long-chain n-3 fatty acid intake to affect total cholesterol and LDL-cholesterol concentrations in the Atherosclerosis Risk in Communities Study. (PubMed id 18541586)1, 4, 9 Volcik K.A....Boerwinkle E. (2008)
    9. Variations in the genes encoding the peroxisome proliferator-activated receptors alpha and gamma in psoriasis. (PubMed id 15083308)1, 4, 9 Mossner R....Reich K. (2004)
    10. [Clinical genetic determinants of carbohydrate metabolism disturbances in patients with hypertension and excessive weight] (PubMed id 15940190)1, 4, 9 Kobalava Z.h.D....Moiseev V.S. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5465 HGNC: 9232 AceView: PPARA Ensembl:ENSG00000186951 euGenes: HUgn5465
    ECgene: PPARA Kegg: 5465 H-InvDB: PPARA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPARA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPARA Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor
    SeattleSNPshttp://pga.gs.washington.edu/data/ppara/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PPARA gene:
    Search GeneIP for patents involving PPARA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PPARA
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for PPARA (PPAR alpha/NR1C1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PPARA   OriGene RNAi products in human, mouse, rat for PPARA  
     OriGene qPCR primer pairs and template standards for PPARA   OriGene Protein Over-expression Lysate for PPARA  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PPARA  
     OriGene qSTAR qPCR primer pairs in human, mouse for PPARA   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PPARA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PPARA   OriGene Custom Protein Services for PPARA  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PPARA
     QIAGEN SeqTarget long-range PCR primers for resequencing PPARA
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPARA
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPARA
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PPARA
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PPARA
     GenScript Custom Purified and Recombinant Proteins Services for PPARA GenScript cDNA clones with any tag delivered in your preferred vector for PPARA
     GenScript Custom Assay Services for PPARA GenScript Superior Antibodies for PPARA
     GenScript Custom overexpressing Cell Line Services for PPARA CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PPARA promoter
     Search Chromatin IP Primers for PPARA
     RT2 qPCR Primer Assay in human, mouse, rat PPARA
     GNC Network for PPARA
     SABiosciences PCR Arrays including human, mouse, rat PPARA
     Tocris compounds for PPARA
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for PPARA
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for PPARA
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PPARA antibodies
     PPARA proteins
     PPARA lysates
     Antibodies for PPARA
     See all of Abcam's Antibodies, Kits and Proteins for PPARA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for PPARA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPARA
     SwitchGear 3'UTR luciferase reporter plasmids for PPARA
     SwitchGear Promoter luciferase reporter plasmids for PPARA
     ThermoFisher Antibody for PPARA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PPARA
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PPARA
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PPARA
    Customized:
     lentivirus for stable overexpression of PPARA
     lentivirus expression plasmids for stable overexpression of PPARA
     adenovirus for overexpression of PPARA
     LSBio Antibodies in human, mouse, rat for PPARA
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PPARA gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4