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Aliases for PPARA Gene

Aliases for PPARA Gene

  • Peroxisome Proliferator-Activated Receptor Alpha 2 3
  • PPAR 3 4 6
  • Peroxisome Proliferative Activated Receptor, Alpha 2 3
  • Nuclear Receptor Subfamily 1 Group C Member 1 3 4
  • PPAR-Alpha 3 4
  • NR1C1 3 4
  • Peroxisome Proliferator-Activated Nuclear Receptor Alpha Variant 3 3
  • PPARalpha 3
  • HPPAR 3

External Ids for PPARA Gene

Previous HGNC Symbols for PPARA Gene

  • PPAR

Previous GeneCards Identifiers for PPARA Gene

  • GC22P043114
  • GC22P044760
  • GC22P044868
  • GC22P044954
  • GC22P046546
  • GC22P029490

Summaries for PPARA Gene

Entrez Gene Summary for PPARA Gene

  • Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPARA Gene

PPARA (Peroxisome Proliferator-Activated Receptor Alpha) is a Protein Coding gene. Diseases associated with PPARA include tularemia and alcoholic cardiomyopathy. Among its related pathways are L1CAM interactions and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein domain specific binding. An important paralog of this gene is NR1I2.

UniProtKB/Swiss-Prot for PPARA Gene

  • Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

Tocris Summary for PPARA Gene

  • Peroxisome proliferator-activated receptor alpha (PPARalpha) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor (RXR) to regulate gene expression. PPARalpha is located primarily in the liver, adipose tissue, kidney, heart, skeletal muscle and large intestine where it is thought to regulate fatty acid synthesis and oxidation, gluconeogenesis, ketogenesis and lipoprotein assembly. The human gene encoding PPARalpha has been localized to chromosome 22 (22q12-13.1).

Gene Wiki entry for PPARA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPARA Gene

Genomics for PPARA Gene

Regulatory Elements for PPARA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPARA Gene

Start:
46,150,521 bp from pter
End:
46,243,756 bp from pter
Size:
93,236 bases
Orientation:
Plus strand

Genomic View for PPARA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPARA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPARA Gene

Proteins for PPARA Gene

  • Protein details for PPARA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07869-PPARA_HUMAN
    Recommended name:
    Peroxisome proliferator-activated receptor alpha
    Protein Accession:
    Q07869
    Secondary Accessions:
    • B0G0X3
    • Q16241
    • Q6I9S0
    • Q92486
    • Q92689
    • Q9Y3N1

    Protein attributes for PPARA Gene

    Size:
    468 amino acids
    Molecular mass:
    52225 Da
    Quaternary structure:
    • Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator. Interacts with CITED2; the interaction stimulates its transcriptional activity. Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6. Interacts with ASXL1 AND ASXL2. Interacts with PER2.

    Three dimensional structures from OCA and Proteopedia for PPARA Gene

    Alternative splice isoforms for PPARA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPARA Gene

Proteomics data for PPARA Gene at MOPED

Post-translational modifications for PPARA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPARA Gene

Antibody Products

  • R&D Systems Antibodies for PPARA (PPAR alpha/NR1C1)

No data available for DME Specific Peptides for PPARA Gene

Domains for PPARA Gene

Gene Families for PPARA Gene

Graphical View of Domain Structure for InterPro Entry

Q07869

UniProtKB/Swiss-Prot:

PPARA_HUMAN :
  • Q07869
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
genes like me logo Genes that share domains with PPARA: view

Function for PPARA Gene

Molecular function for PPARA Gene

GENATLAS Biochemistry: peroxisome proliferator-activated receptor,alpha isoform,steroid/thyroid hormone receptor superfamily,heterodimerizing with RXR*,highly expressed in liver,involved in the control of fatty acid synthesis,oxidation and ketogenesis,plyaing a critical role in the cellular fasting response
UniProtKB/Swiss-Prot Function: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

Gene Ontology (GO) - Molecular Function for PPARA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 9748239
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 9748239
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 9748239
GO:0001103 RNA polymerase II repressing transcription factor binding IPI 19955185
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription IEA --
genes like me logo Genes that share ontologies with PPARA: view
genes like me logo Genes that share phenotypes with PPARA: view

Animal Models for PPARA Gene

MGI Knock Outs for PPARA:

Animal Model Products

CRISPR Products

Transcription Factor Targeting for PPARA Gene

Selected GeneGlobe predicted Target genes for PPARA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPARA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for PPARA Gene

Localization for PPARA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPARA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPARA Gene COMPARTMENTS Subcellular localization image for PPARA gene
Compartment Confidence
nucleus 5
peroxisome 4
cytosol 2
extracellular 2
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PPARA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 16271724
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PPARA: view

Pathways for PPARA Gene

genes like me logo Genes that share pathways with PPARA: view

PCR Array Products

Gene Ontology (GO) - Biological Process for PPARA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12700342
GO:0001666 response to hypoxia IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006629 lipid metabolic process TAS 7684926
genes like me logo Genes that share ontologies with PPARA: view

Compounds for PPARA Gene

(5) Tocris Compounds for PPARA Gene

Compound Action Cas Number
CP 775146 Selective, high affinity PPARalpha agonist [702680-17-9]
GW 6471 PPARalpha antagonist [880635-03-0]
GW 7647 Highly selective, potent PPARalpha agonist. Orally active [265129-71-3]
Palmitoylethanolamide Selective GPR55 agonist. FAAH and PAA substrate [544-31-0]
WY 14643 Selective PPARalpha agonist [50892-23-4]

(34) HMDB Compounds for PPARA Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(8) Drugbank Compounds for PPARA Gene

(25) IUPHAR Ligand for PPARA Gene

Ligand Type Action Affinity Pubmed IDs
GW409544 Agonist Agonist 8.7
GW7647 Agonist Agonist 8.22
MK-0767 Agonist Agonist 7.64
TZD18 Agonist Agonist 7.6
LY-518674 Agonist Agonist 7.6
LY-510929 Agonist Agonist 7.55
imiglitazar Agonist Agonist 7.17
8S-HETE Agonist Agonist 7
LY-465608 Agonist Agonist 6.8
NS-220 Agonist Agonist 6.73
GW6471 Antagonist Antagonist 6.6
oleoylethanolamide Agonist Agonist 6.5
farglitazar Agonist Agonist 6.35
pirinixic acid Agonist Agonist 6.22
ragaglitazar Agonist Agonist 6
GW9578 Agonist Full agonist 5.9
reglitazar Agonist Agonist 5.72
AD-5061 Agonist Agonist 5.6
DRF 2519 Agonist Agonist 5
pristanic acid Agonist Agonist 4.4
bezafibrate Agonist Agonist 4.3
clofibrate Agonist Agonist 4.25
fenofibric acid Channel blocker None
gemfibrozil Inhibitor Inhibition
ciprofibrate Agonist Agonist

(141) Novoseek inferred chemical compound relationships for PPARA Gene

Compound -log(P) Hits PubMed IDs
fenofibrate 92.5 139
wy14643 92.1 79
rosiglitazone 87.5 66
ciglitazone 86.6 26
15-deoxy-delta-12,14-prostaglandin j2 85.9 25

(4) PharmGKB related drug/compound annotations for PPARA Gene

Drug/compound Annotation
Beta Blocking Agents CA
fenofibrate CA
simvastatin CA
tacrolimus CA
genes like me logo Genes that share compounds with PPARA: view

Transcripts for PPARA Gene

Unigene Clusters for PPARA Gene

Peroxisome proliferator-activated receptor alpha:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPARA

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPARA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b
SP1: - - -
SP2: - - -
SP3: -
SP4: - - - -
SP5: - - - -
SP6: - - -
SP7: - - - -
SP8: -

Relevant External Links for PPARA Gene

GeneLoc Exon Structure for
PPARA
ECgene alternative splicing isoforms for
PPARA

Expression for PPARA Gene

mRNA expression in normal human tissues for PPARA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPARA Gene

This gene is overexpressed in Liver (5.8).

SOURCE GeneReport for Unigene cluster for PPARA Gene Hs.103110

mRNA Expression by UniProt/SwissProt for PPARA Gene

Q07869-PPARA_HUMAN
Tissue specificity: Skeletal muscle, liver, heart and kidney.
genes like me logo Genes that share expressions with PPARA: view

In Situ Assay Products

No data available for Protein expression for PPARA Gene

Orthologs for PPARA Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPARA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPARA 35
  • 99.57 (n)
  • 100 (a)
PPARA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPARA 35
  • 85.75 (n)
  • 94.87 (a)
PPARA 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPARA 35
  • 87.46 (n)
  • 94.66 (a)
PPARA 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppara 35
  • 85.54 (n)
  • 92.31 (a)
Ppara 16
Ppara 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPARA 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPARA 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppara 35
  • 85.19 (n)
  • 92.09 (a)
chicken
(Gallus gallus)
Aves PPAR 36
  • 89 (a)
OneToOne
PPARA 35
  • 79.2 (n)
  • 88.89 (a)
lizard
(Anolis carolinensis)
Reptilia PPARA 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68537 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497346 35
  • 73.95 (n)
  • 81.8 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100534818 35
  • 72.67 (n)
  • 79.44 (a)
pparaa 36
  • 66 (a)
OneToMany
pparab 36
  • 73 (a)
OneToMany
pparab 36
  • 77 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for PPARA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPARA Gene

ENSEMBL:
Gene Tree for PPARA (if available)
TreeFam:
Gene Tree for PPARA (if available)

Paralogs for PPARA Gene

Selected SIMAP similar genes for PPARA Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PPARA: view

Variants for PPARA Gene

Sequence variations from dbSNP and Humsavar for PPARA Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs129600 -- 46,161,262(-) CCTTC(C/T)GAAAT intron-variant
rs135536 -- 46,172,421(-) CAACT(C/G)CTGAC intron-variant
rs135537 -- 46,172,172(-) ACCTG(A/G)AGGAG intron-variant
rs135538 -- 46,168,728(-) tctac(C/G)aagag intron-variant
rs135539 -- 46,163,368(-) GTTAA(G/T)AATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPARA Gene

Variant ID Type Subtype PubMed ID
dgv5004n71 CNV Loss 21882294
nsv829281 CNV Gain 20364138
dgv5006n71 CNV Loss 21882294
dgv5008n71 CNV Loss 21882294
nsv915336 CNV Loss 21882294
nsv915340 CNV Loss 21882294
dgv5012n71 CNV Loss 21882294
nsv834224 CNV Loss 17160897
nsv915346 CNV Loss 21882294
esv2667871 CNV Deletion 23128226
nsv191496 CNV Loss 16902084
dgv5013n71 CNV Loss 21882294
nsv819654 CNV Gain 19587683
nsv829293 CNV Gain 20364138

Relevant External Links for PPARA Gene

HapMap Linkage Disequilibrium report
PPARA
Human Gene Mutation Database (HGMD)
PPARA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPARA Gene

Disorders for PPARA Gene

(94) Novoseek inferred disease relationships for PPARA Gene

Disease -log(P) Hits PubMed IDs
dyslipidemia 79.9 69
insulin resistance 77.1 68
insulin sensitivity 74.7 52
atherosclerosis 73.8 106
fatty liver 71.4 23

Relevant External Links for PPARA

Genetic Association Database (GAD)
PPARA
Human Genome Epidemiology (HuGE) Navigator
PPARA
genes like me logo Genes that share disorders with PPARA: view

No data available for UniProtKB/Swiss-Prot for PPARA Gene

Publications for PPARA Gene

  1. Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. (PMID: 7981125) Mukherjee R. … McDonnell D.P. (J. Steroid Biochem. Mol. Biol. 1994) 3 4 23
  2. Peroxisome proliferator-activated receptors: structures and function. (PMID: 8993548) Tugwood J.D. … Woodyatt N.J. (Ann. N. Y. Acad. Sci. 1996) 3 4 23
  3. Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR. (PMID: 10195690) Gorla-Bajszczak A. … Meier C.A. (Mol. Cell. Endocrinol. 1999) 3 4 23
  4. Mutation screening of the PPARalpha gene in type 2 diabetes associated with coronary heart disease. (PMID: 11119019) Lacquemant C. … Froguel P. (Diabetes Metab. 2000) 3 23 48
  5. A polymorphism, L162V, in the peroxisome proliferator-activated receptor alpha (PPARalpha) gene is associated with lower body mass index in patients with non-insulin-dependent diabetes mellitus. (PMID: 11409711) Evans D. … Mann W.A. (J. Mol. Med. 2001) 3 23 48

Products for PPARA Gene

  • Addgene plasmids for PPARA

Sources for PPARA Gene

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