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PPAPDC1A Gene

protein-coding   GIFtS: 53
GCID: GC10P122207

Phosphatidic Acid Phosphatase Type 2 Domain Containing 1A

(Previous name: phosphatidic acid phosphatase type 2 domain containing 1)
(Previous symbol: PPAPDC1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphatidic Acid Phosphatase Type 2 Domain Containing 1A1 2     Phosphatidic Acid Phosphatase Type 2 Domain Containing 11
PPAPDC11 2 3     Diacylglycerol Pyrophosphate Like 22
Phosphatidic Acid Phosphatase Type 2 Domain-Containing Protein 1A2 3     Phosphatidate Phosphatase PPAPDC1A2
DPPL22 3     EC 3.1.3.43

External Ids:    HGNC: 235311   Entrez Gene: 1960512   Ensembl: ENSG000002038057   UniProtKB: Q5VZY23   

Export aliases for PPAPDC1A gene to outside databases

Previous GC identifer: GC10P115845


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PPAPDC1A Gene:
PPAPDC1A (phosphatidic acid phosphatase type 2 domain containing 1A) is a protein-coding gene. GO annotations related to this gene include phosphatidate phosphatase activity. An important paralog of this gene is PPAPDC1B.

UniProtKB/Swiss-Prot: PPC1A_HUMAN, Q5VZY2
Function: Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of
phosphatidic acid to diacylglycerol

Gene Wiki entry for PPAPDC1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PPAPDC1A gene promoter:
         COUP-TF1   STAT1   Pbx1a   COUP   HNF-4alpha2   Ik-3   STAT1alpha   HNF-4alpha1   HEN1   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPPAPDC1A promoter sequence
   Search Chromatin IP Primers for PPAPDC1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PPAPDC1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.12   Ensembl cytogenetic band:  10q26.12   HGNC cytogenetic band: 10q26.13

PPAPDC1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPAPDC1A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P122207:  view genomic region     (about GC identifiers)

Start:
122,216,466 bp from pter      End:
122,349,367 bp from pter
Size:
132,902 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PPC1A_HUMAN, Q5VZY2 (See protein sequence)
Recommended Name: Phosphatidate phosphatase PPAPDC1A  
Size: 271 amino acids; 30395 Da
Sequence caution: Sequence=CAH70333.1; Type=Erroneous gene model prediction;
Secondary accessions: A2RU82 Q08EQ2 Q0IIP2 Q495B4 Q5VZY1
Alternative splicing: 4 isoforms:  Q5VZY2-1   Q5VZY2-2   Q5VZY2-3   Q5VZY2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PPAPDC1A: NX_Q5VZY2

Explore proteomics data for PPAPDC1A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PPAPDC1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001025230.1  
    ENSEMBL proteins: 
     ENSP00000407979   ENSP00000358069   ENSP00000381302   ENSP00000403508   ENSP00000381300  
     ENSP00000440493  
    Reactome Protein details: Q5VZY2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000326 P_Acid_Pase_2/haloperoxidase
     IPR028664 PPAPDC1A

    Graphical View of Domain Structure for InterPro Entry Q5VZY2

    ProtoNet protein and cluster: Q5VZY2

    1 Blocks protein domain: IPB000326 PA-phosphatase related phosphoesterase

    UniProtKB/Swiss-Prot: PPC1A_HUMAN, Q5VZY2
    Similarity: Belongs to the PA-phosphatase related phosphoesterase family


    Find genes that share domains with PPAPDC1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPC1A_HUMAN, Q5VZY2
    Function: Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of
    phosphatidic acid to diacylglycerol
    Catalytic activity: A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate
    Enzyme regulation: Inhibited by N-ethylmaleimide
    Biophysicochemical properties: Kinetic parameters: KM=104 uM for diacylglycerol pyrophosphate; KM=506 uM for
    phosphatidate; KM=580 uM for lysophosphatidate;

         Enzyme Number (IUBMB): EC 3.1.3.41

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0008195phosphatidate phosphatase activity IDA17590538
         
    Find genes that share ontologies with PPAPDC1A           About GenesLikeMe


    Animal Models:
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    hsa-miR-570
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPC1A_HUMAN, Q5VZY2: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum1
    lysosome1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PPAPDC1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PPAPDC1A About    
    See pathways by source

    SuperPathContained pathways About
    1Fcgamma receptor (FCGR) dependent phagocytosis
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    2Creation of C4 and C2 activators
    Role of phospholipids in phagocytosis0.53
    3triacylglycerol biosynthesis
    triacylglycerol biosynthesis0.48


    Find genes that share SuperPaths with PPAPDC1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PPAPDC1A
        triacylglycerol biosynthesis

    1 Reactome Pathway for PPAPDC1A
        Role of phospholipids in phagocytosis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PPAPDC1A
    Interactions:

        Search GeneGlobe Interaction Network for PPAPDC1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for PPAPDC1A (Q5VZY23 ENSP000003813024) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GGPS1O957493, ENSP000002828414I2D: score=1 STRING: ENSP00000282841
    HMGCRP040353, ENSP000002879364I2D: score=1 STRING: ENSP00000287936
    ATP2B3Q167203I2D: score=4 
    ABCB10Q9NRK63I2D: score=1 
    ABCD2Q9UBJ23I2D: score=1 
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    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--
    GO:0046839phospholipid dephosphorylation IDA17590538

    Find genes that share ontologies with PPAPDC1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PPAPDC1A (PPC1A)

    Selected HMDB Compounds for PPAPDC1A (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PA(16:0/16:0)Dipalmitoylphosphatidic acid (see all 25)7091-44-3--
    PA(16:0/18:1(11Z))PA(16:0/18:1n7) (see all 10)----
    PA(16:0/18:1(9Z))PA(16:0/18:1n9) (see all 10)----
    PA(16:0/18:2(9Z,12Z))PA(34:2) (see all 10)----
    PA(16:0e/18:0)2-octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate ;PA(o-16:0/18:0) ----
    PA(18:0/18:2(9Z,12Z))PA(36:2) (see all 10)----
    PA(18:1(11Z)/18:1(11Z))PA(36:2) (see all 10)----
    PA(18:1(11Z)/18:1(9Z))PA(36:2) (see all 10)----
    PA(18:1(9Z)/18:1(11Z))PA(36:2) (see all 10)----
    PA(18:1(9Z)/18:1(9Z))PA(36:2) (see all 10)14268-17-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PPAPDC1A gene: 
    NM_001030059.1  

    Unigene Cluster for PPAPDC1A:

    Phosphatidic acid phosphatase type 2 domain containing 1A
    Hs.40479  [show with all ESTs]
    Unigene Representative Sequence: NM_001030059
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427079 ENST00000369073(uc001ley.1) ENST00000496437 ENST00000398250(uc001lev.1)
    ENST00000439221(uc009xzl.1 uc001lew.1) ENST00000398248(uc001lex.1)
    ENST00000541332(uc010qtd.2)
    miRNA
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    hsa-miR-570
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    Additional mRNA sequence: 

    AK098668.1 AK296273.1 AK310178.1 BC101267.2 BC101268.2 BC101269.1 BC122535.1 BC132787.1 

    2 DOTS entries:

    DT.309587  DT.121252446 

    23 AceView cDNA sequences:

    AK098668 AI418830 BM930630 AA424650 CA433964 CA434138 BI550027 CD557662 
    AA418447 AW026561 CF264786 BU743282 AI126772 AA631750 BG191521 N22732 
    N25267 BG217560 H83701 BG216388 BG209093 H83353 CB994970 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PPAPDC1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGTAAAAC
    PPAPDC1A Expression
    About this image


    PPAPDC1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
     
     Fibroblasts
             Detroit 551
     
     Epidermis (Integumentary System)
             Detroit 551
     
     NULL (Uncategorized)
             Definitive endoderm-like cells
    PPAPDC1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PPAPDC1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.40479

    UniProtKB/Swiss-Prot: PPC1A_HUMAN, Q5VZY2
    Tissue specificity: Expressed mainly to the brain, kidney and testis, and to a lesser extent the bone marrow,
    thymus, prostate, liver and uterus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PPAPDC1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PPAPDC1A gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ppapdc1a1 , 5 phosphatidic acid phosphatase type 2 domain containing more1, 5 92(n)1
    99.26(a)1
      7 (71.63 cM)5
    3819251  NM_001080963.11  NP_001074432.11 
     1292570945 
    chicken
    (Gallus gallus)
    Aves PPAPDC1A1 phosphatidic acid phosphatase type 2 domain containing more 84.13(n)
    94.1(a)
      428987  XM_426544.4  XP_426544.3 
    lizard
    (Anolis carolinensis)
    Reptilia PPAPDC1A6
    phosphatidic acid phosphatase type 2 domain contai...
    78(a)
    1 ↔ 1
    3(65517439-65711710)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004877281 phosphatidate phosphatase PPAPDC1A-like 73.43(n)
    83.03(a)
      100487728  XM_002937808.2  XP_002937854.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003347941 phosphatidic acid phosphatase type 2C-like 73.87(n)
    79.6(a)
      100334794  XM_002664083.3  XP_002664129.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG127466
    --
    31(a)
    1 → many
    3R(1390593-1393157)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DPP1(YDR284C)4 Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated more   --   4(1031419-1030550) 851878  NP_010570.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons LPP21 LPP2 49.09(n)
    41(a)
      838072  NM_101377.4  NP_172961.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g03592001 Os08g0359200 47.85(n)
    40.1(a)
      4345367  NM_001068164.1  NP_001061629.1 


    ENSEMBL Gene Tree for PPAPDC1A (if available)
    TreeFam Gene Tree for PPAPDC1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PPAPDC1A gene
    PPAPDC1B2  
    1 SIMAP similar gene for PPAPDC1A using alignment to 2 protein entries:     PPC1A_HUMAN (see all proteins):
    PPAPDC1B

    Find genes that share paralogs with PPAPDC1A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PPAPDC1A (see all 2932)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1410405741,2
    C--115843693(+) TGCCCA/GGCTAA 1 -- us2k10--------
    rs24783971,2
    C,A,H--122214477(-) CTCAAA/GATACA 1 -- us2k16Minor allele frequency- G:0.10NA WA CSA 10
    rs79060361,2
    C--122214551(+) GCCTCA/GGGCTC 1 -- us2k10--------
    rs1908265411,2
    --122214556(+) GGGCTA/CCCAAA 1 -- us2k10--------
    rs1830054131,2
    --122214568(+) TGCTGG/TGATTA 1 -- us2k10--------
    rs79057101,2
    C,F,A,H--122214575(+) ATTACG/AGACAT 1 -- us2k15Minor allele frequency- A:0.40NA WA CSA 127
    rs111993461,2
    C,F--122214591(+) atcgcG/Acctgg 1 -- us2k12Minor allele frequency- A:0.05WA EA 238
    rs1489451751,2
    --122214700(+) AAGCAC/TGTGTT 1 -- us2k10--------
    rs1866366581,2
    --122214806(+) GTCTCA/GCCCAG 1 -- us2k10--------
    rs1909896881,2
    C--122214892(+) TTGTCA/GGAATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PPAPDC1A (122216466 - 122349367 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PPAPDC1A (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676968CNV Deletion23128226
    esv2741940CNV Deletion23290073
    esv995047CNV Deletion20482838
    esv2546781CNV Deletion19546169
    nsv436106CNV Deletion17901297
    esv2669932CNV Deletion23128226
    nsv821211CNV Deletion20802225
    dgv174n67CNV Loss20364138
    nsv511435CNV Loss21212237
    nsv512187CNV Loss21212237

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with PPAPDC1A           About GenesLikeMe

    Genetic Association Database (GAD): PPAPDC1A
    Human Genome Epidemiology (HuGE) Navigator: PPAPDC1A (1 document)

    Export disorders for PPAPDC1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PPAPDC1A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PPAPDC1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase. (PubMed id 17590538)1, 2 Takeuchi M....Kamatani N. (Gene 2007)
    3. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PubMed id 23535033)1 Sherva R....Green R.C. (amp 2014)
    4. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....MunafA^ M.R. (Pharmacogenomics 2010)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 196051 HGNC: 23531 AceView: PPAPDC1 Ensembl:ENSG00000203805 euGenes: HUgn196051
    ECgene: PPAPDC1A H-InvDB: PPAPDC1A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PPAPDC1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PPAPDC1A gene:
    Search GeneIP for patents involving PPAPDC1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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