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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PPAP2B Gene

protein-coding   GIFtS: 60
GCID: GC01M056879

phosphatidic acid phosphatase type 2B
 Explore 5 diseases affiliated with
PPAP2B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PPAP2B    

Aliases
for PPAP2B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Phosphatidic Acid Phosphatase Type 2B1 2     Lipid Phosphate Phosphohydrolase 32
LPP31 2 3     PAP2 Beta2
PAP-2b1 3     Type-2 Phosphatidic Acid Phosphatase-Beta2
Phosphatidate Phosphohydrolase Type 2b2 3     Vascular Endothelial Growth Factor And Type I Collagen Inducible2
VCIP2 3     PAP2-Beta1
EC 3.1.3.43 8     PAP2b3
Dri422     Phosphatidic Acid Phosphatase 2b3
PAP2B2     Vascular Endothelial Growth Factor And Type I Collagen-Inducible Protein3

External Ids:    HGNC: 92291   Entrez Gene: 86132   Ensembl: ENSG000001624077   OMIM: 6071255   UniProtKB: O144953   

Export aliases for PPAP2B gene to outside databases

Previous GC identifers: GC01M055877 GC01M056317 GC01M056329 GC01M056330 GC01M056671 GC01M056733 GC01M055072


Summaries
for PPAP2B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PPAP2B:
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert
phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in
receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized
at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and
short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela
cells. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: LPP3_HUMAN, O14495
Function: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes
lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic
efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions

Gene Wiki entry for PPAP2B


Genomic Views
for PPAP2B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PPAP2B gene promoter:
         FOXC1   HFH-1   HNF-4alpha2   LyF-1   NF-kappaB1   Hlf   GATA-1   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PPAP2B promoter sequence
   Search SABiosciences Chromatin IP Primers for PPAP2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PPAP2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.2   Ensembl cytogenetic band:  1p32.2   HGNC cytogenetic band: 1p32.2

PPAP2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PPAP2B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M056879:  view genomic region     (about GC identifiers)

Start:
 56,960,419 bp from pter      End:
 57,110,974 bp from pter
Size:
 150,556 bases      Orientation:
 minus strand

Proteins
for PPAP2B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LPP3_HUMAN, O14495 (See protein sequence)
Recommended Name: Lipid phosphate phosphohydrolase 3  
Size: 311 amino acids; 35116 Da
Subunit: Homodimer. This complex seems not to be involved in substrate recognition, it may confer only structural or
functional stability
Subcellular location: Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane;
Multi-pass membrane protein
Sequence caution: Sequence=AAB50222.1; Type=Frameshift; Positions=225;
Secondary accessions: B2R651 D3DQ52 Q96GW0 Q99782

Explore the universe of human proteins at neXtProt for PPAP2B: NX_O14495

Post-translational modifications:

  • N-glycosylated. Contains high-mannose oligosaccharides1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14495

    • 2 DME Specific Peptides for PPAP2B (O14495)
     DESIKYP  SIGRLRPHF 

    PPAP2B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003704.3  
    ENSEMBL proteins: 
     ENSP00000360296  
    Reactome Protein details: O14495
    Human Recombinant Protein Products: 
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    Novus Biologicals PPAP2B Protein
    Novus Biologicals PPAP2B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PPAP2B

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane ----
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane TAS--
    GO:0005912adherens junction TAS--
    GO:0016020membrane TAS9305923


    PPAP2B for ontologies           About GeneDecksing



    PPAP2B Antibody Products: 
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    Uscn Antibodies for PPAP2B
    ThermoFisher Antibodies for PPAP2B

    Assay Products for PPAP2B: 
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    Uscn ELISAs and CLIAs for PPAP2B

    Protein Domains /
    Families
    for PPAP2B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PPAP2B for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000326 P_Acid_Pase_2/haloperoxidase
     IPR016118 P_Acid_Pase/Cl_peroxidase_N

    Graphical View of Domain Structure for InterPro Entry O14495

    ProtoNet protein and cluster: O14495

    1 Blocks protein family: IPB000326 PA-phosphatase related phosphoesterase

    UniProtKB/Swiss-Prot: LPP3_HUMAN, O14495
    Similarity: Belongs to the PA-phosphatase related phosphoesterase family


    Function
    for PPAP2B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LPP3_HUMAN, O14495
    Function: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes
    lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic
    efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions
    Catalytic activity: A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate
    Enzyme regulation: Inhibited by sphingosine, zinc ions and propanolol. Not inhibited by N-ethylmaleimide treatment
    Induction: By EGF, VEGF, FGF2 and phorbol myristate acetate (PMA)

    Enzyme Number (IUBMB): EC 3.1.3.41 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PPAP2B
    8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate PPAP2B (see all 85):
    hsa-miR-323-3p hsa-miR-3152-3p hsa-miR-520f hsa-miR-15a hsa-miR-128 hsa-miR-374a hsa-miR-149 hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmid: PPAP2B 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPAP2B (see all 7)
    OriGene shRNA RFP: PPAP2B
    OriGene siRNA: PPAP2B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPAP2B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PPAP2B

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPAP2B (see all 4)
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    Cell Line
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    Search LifeMap BioReagents cell lines for PPAP2B

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity TAS9705349
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI--
    GO:0008195phosphatidate phosphatase activity IEA--
    GO:0042577lipid phosphatase activity IEA--


    PPAP2B for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for PPAP2B:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 
     Increased cilium length after  

    Animal Models:
         Mouse knock-outs for PPAP2B: Ppap2btm3.1Stw Ppap2btm1Stw
         7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ppap2b):
     cardiovascular system  embryogenesis  growth/size  homeostasis/metabolism  mortality/aging 
     nervous system  normal 

    PPAP2B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PPAP2B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    4TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JAK-STAT Pathway0.57
    		MAPK Family Pathway0.60
    		JNK Pathway0.50
    5Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/63 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PPAP2B (see all 63)
        Nuclear Receptor Activation by Vitamin-A
    RhoA Pathway
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis

    2 BioSystems Pathways for PPAP2B 
        Triacylglyceride Synthesis
    triacylglycerol biosynthesis

    4        Reactome Pathways for PPAP2B
        Sphingolipid metabolism
    Metabolism
    Metabolism of lipids and lipoproteins
    Sphingolipid de novo biosynthesis


    5/7         Kegg Pathways  (Kegg details for PPAP2B) (see all 7):
        Glycerolipid metabolism
    Glycerophospholipid metabolism
    Ether lipid metabolism
    Sphingolipid metabolism
    Metabolic pathways


    PPAP2B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PPAP2B

    5/9 Interacting proteins for PPAP2B (O144952, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL6P411823I2D: score=3 
    SHC1P293533I2D: score=2 
    BCAR1P569453I2D: score=1 
    DLG4P783523I2D: score=1 
    YWHABP319463I2D: score=1 
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001568blood vessel development IEA--
    GO:0001702gastrulation with mouth forming second IEA--
    GO:0001933negative regulation of protein phosphorylation IDA--
    GO:0006629lipid metabolic process NAS9705349
    GO:0006644phospholipid metabolic process TAS--


    PPAP2B for ontologies           About GeneDecksing



    Drugs & Compounds
    for PPAP2B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PPAP2B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PPAP2B

    10/883 HMDB Compounds for PPAP2B (see all 883)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Lyso-2-arachidonoyl-phosphatidateL-beta-arachidonoyl-alpha-lysophosphatidic acid;2-arachidonoyl-lysophosphatidic acid;2-all-cis-5,8,11,14-eicosatetraenoyl-lysophosphatidic acid;2-arachidonoyl-sn-glycero-3-phosphate;1-lyso-2-all-cis-5,8,11,14-eicosatetraenoyl-sn-glycero-3-phosphatidic acid ----
    Ceramide (d18:1/12:0)(2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol (see all 6)104404-17-3--
    Ceramide (d18:1/16:0)(2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol (see all 6)104404-17-3--
    Ceramide (d18:1/18:0)(2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol (see all 6)104404-17-3--
    Ceramide (d18:1/20:0)(2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol (see all 6)104404-17-3--
    Ceramide (d18:1/22:0)(2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol (see all 6)104404-17-3--
    Ceramide (d18:1/24:0)(2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol (see all 6)104404-17-3--
    Ceramide (d18:1/24:1(15Z))(2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol (see all 7)104404-17-3--
    Ceramide (d18:1/25:0)(2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol (see all 6)104404-17-3--
    Ceramide (d18:1/26:0)(2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol (see all 6)104404-17-3--
    2 Novoseek chemical compound relationships for PPAP2B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ceramide 1-phosphate 88 2 12615725 (1), 15271294 (1)
    lipid 10.4 1 16946011 (1)

    Search CenterWatch for drugs/clinical trials and news about PPAP2B / LPP3 

    Transcripts
    for PPAP2B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PPAP2B gene (2 alternative transcripts): 
    NM_003713.4  NM_177414.1  

    Unigene Cluster for PPAP2B:

    Phosphatidic acid phosphatase type 2B
    Hs.405156  [show with all ESTs]
    Unigene Representative Sequence: NM_003713
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371250(uc001cyj.2) ENST00000472957 ENST00000459962 ENST00000461655
    ENST00000476206

    miRNA
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    8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate PPAP2B (see all 85):
    hsa-miR-323-3p hsa-miR-3152-3p hsa-miR-520f hsa-miR-15a hsa-miR-128 hsa-miR-374a hsa-miR-149 hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmid: PPAP2B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PPAP2B (see all 7)
    OriGene shRNA RFP: PPAP2B
    OriGene siRNA: PPAP2B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PPAP2B
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PPAP2B (see all 4)
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    GenScript: all cDNA clones in your preferred vector: PPAP2B (NM_003713)
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    Primer
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    Additional cDNA sequence: 

    AB000889.1 AF017786.1 AF043329.1 AK123105.1 AK312439.1 BC009196.2 BT019589.1 U79294.1 

    18 DOTS entries:

    DT.91784265  DT.91784147  DT.95359092  DT.97859173  DT.100885171  DT.95338464  DT.100885172  DT.100885164 
    DT.120268  DT.95358933  DT.91724647  DT.100808663  DT.95358932  DT.100648619  DT.100885170  DT.121335234 
    DT.91784296  DT.91922431 

    24/627 AceView cDNA sequences (see all 627):

    AW139636 BX335951 BU682000 CR599005 T35116 AA600348 AI870882 Z41044 
    AA234491 BQ022173 U79294 BU628625 AW338517 T35115 F12729 BM707272 
    AI127576 BM711198 BX399314 F10343 CA392119 AL042718 AI143224 CN483107 

    GeneLoc Exon Structure


    Expression
    for PPAP2B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PPAP2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACATCCTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PPAP2B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Paraxial Mesoderm CellsBone, Skeletal Muscle
    HeartMyocardiumMature Cardiac FibroblastsEpicardium
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Trophoblast-like cells (Generation of tropho...)
    Primitive gut tube-like cells (A scalable, suspensi...)

    See PPAP2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PPAP2B

    SOURCE GeneReport for Unigene cluster: Hs.405156

    UniProtKB/Swiss-Prot: LPP3_HUMAN, O14495
    Tissue specificity: Ubiquitously expressed. Highly expressed in heart and placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including PPAP2B: 
              Adherens Junctions in human mouse rat
              WNT Signaling Targets in human mouse rat

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    Orthologs
    for PPAP2B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PPAP2B gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PPAP2B1 phosphatidic acid phosphatase type 2B 79.96(n)
    83.6(a)    		   424666  NM_001130488.1  NP_001123960.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PPAP2B6
    		 --
    		 84(a)
    		 1 ↔ 1
    		 4(103484561-103520646)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CF520573.12   -- 76.5(n)    CF520573.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.289462 Transcribed sequence 88.64(n)    CK025598.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 21(a)
    		 possible ortholog
    		 GroupUn.6596(8577-15798)
    worm
    (Caenorhabditis elegans)    		 Secernentea F53C3.136
    F13E6.56
    (see all 3)    		 Protein F13E6.5
    (see all 3)    		 26(a)
    22(a)
    (see all 3)    		 1 ↔ many
    possible ortholog
    (see all 3)    		 II(3920597-3927990)
    X(10695244-10697834)


    ENSEMBL Gene Tree for PPAP2B (if available)
    TreeFam Gene Tree for PPAP2B (if available) 

    Paralogs
    for PPAP2B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PPAP2B gene
    LPPR12  LPPR52  LPPR22  PPAP2C2  PPAP2A2  LPPR42  LPPR32  
    3 SIMAP similar genes for PPAP2B using alignment to 1 protein entry:     LPP3_HUMAN:
    PPAP2A    PPAP2C    LPPR1

    PPAP2B for paralogs           About GeneDecksing



    Genomic Variants
    for PPAP2B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1471 NCBI SNPs in PPAP2B are shown (see all 1471)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1925431021,2
    		--56960090(+) CAGCAA/TACCTT 1 -- ds50010--------
    rs112068301,2
    		C,F,A,H,--56960123(+) CTGCCC/TTCGGG 1 -- ds5001 ese323Minor allele frequency- T:0.20EA NA NS WA 2730
    rs1455070731,2
    		--56960290(+) CACCAC/TATTTC 1 -- ds50010--------
    rs171140171,2
    		C,F,H,--56960360(+) AGCCCG/ACGATG 1 -- ds500110Minor allele frequency- A:0.05NA NS EA WA 794
    rs1835992041,2
    		--56960362(+) CCCGCA/GATGCT 1 -- ds50010--------
    rs1831727991,2
    		C,--56960445(+) TGTTAC/TGAGCT 1 -- ut310--------
    rs1810457081,2
    		--56960665(+) TATTTA/TAAAAA 1 -- ut310--------
    rs1862892331,2
    		--56960692(+) TTTAAG/TCAGCT 1 -- ut310--------
    rs171140181,2
    		C,F,H,--56960714(+) CACAGG/ATCGAG 1 -- ut31 ese315Minor allele frequency- A:0.11NA NS EA WA 1448
    rs1899539151,2
    		--56960734(+) ATAATA/CATAGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PPAP2B (56960419 - 57110974 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PPAP2B: --

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    Disorders / Diseases
    for PPAP2B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PPAP2B for disorders           About GeneDecksing

    OMIM gene information: 607125    OMIM disorders: --

    5 diseases for PPAP2B:    About MalaCards
    gigantism    ovarian cancer    breast cancer    adenocarcinoma
    pancreatitis

    1 Novoseek disease relationship for PPAP2B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 16076388 (2), 12615725 (1)

    Human Genome Epidemiology (HuGE) Navigator: PPAP2B (4 documents)

    Export disorders for PPAP2B gene to outside databases

    Publications
    for PPAP2B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PPAP2B gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with PPAP2B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of two human isozymes of Mg2+- independent phosphatidic acid phosphatase. (PubMed id 9305923)1, 2, 3, 9 Kai M.... Kanoh H. (1997)
    2. Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP. (PubMed id 12660161)1, 2, 9 Humtsoe J.O.... Wary K.K. (2003)
    3. Lipid phosphate phosphatases dimerise, but this interaction is not required for in vivo activity. (PubMed id 14725715)1, 2 Burnett C.... Howard K. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. (PubMed id 9705349)1, 2 Roberts R.... Morris A.J. (1998)
    6. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2 Yu W.... Gibbs R.A. (1997)
    7. Sequential actions of phospholipase D and phosphatidic acid phosphohydrolase 2b generate diglyceride in mammalian cells. (PubMed id 10564277)1, 9 Sciorra V.A. and Morris A.J. (1999)
    8. Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function. (PubMed id 18215144)1, 9 Long J.S....Pyne S. (2008)
    9. Cell surface activities of the human type 2b phosphatidic acid phosphatase. (PubMed id 10739957)1, 9 Ishikawa T....Kanoh H. (2000)
    10. Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand. (PubMed id 16099422)1, 9 Humtsoe J.O....Wary K.K. (2005)

    External Searches for PPAP2B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PPAP2B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8613 HGNC: 9229 AceView: PPAP2B Ensembl:ENSG00000162407 euGenes: HUgn8613
    ECgene: PPAP2B Kegg: 8613 H-InvDB: PPAP2B

    Other Databases showing PPAP2B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PPAP2B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PPAP2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PPAP2B Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PPAP2B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PPAP2B gene:
    Search GeneIP for patents involving PPAP2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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