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Aliases for PPAN Gene

Aliases for PPAN Gene

  • Peter Pan Homolog (Drosophila) 2 3 5
  • Brix Domain-Containing Protein 3 3 4
  • SSF-1 3 4
  • BXDC3 3 4
  • SSF1 3 4
  • Peter Pan (Drosophila) Homolog 2
  • Homolog Of S. Cerevisiae SSF1 3
  • Second-Step Splicing Factor 1 3
  • Suppressor Of SWI4 1 Homolog 3
  • Suppressor Of Sterile Four 1 3
  • Peter Pan Homolog 4
  • SSF2 3
  • SSF 3

External Ids for PPAN Gene

Previous GeneCards Identifiers for PPAN Gene

  • GC19P010338
  • GC19P010439
  • GC19P010062
  • GC19P010077
  • GC19P010216
  • GC19P009819

Summaries for PPAN Gene

Entrez Gene Summary for PPAN Gene

  • The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010]

GeneCards Summary for PPAN Gene

PPAN (Peter Pan Homolog (Drosophila)) is a Protein Coding gene. Diseases associated with PPAN include Kummell's Disease and Enterocele. An important paralog of this gene is PPAN-P2RY11.

UniProtKB/Swiss-Prot for PPAN Gene

  • May have a role in cell growth.

Gene Wiki entry for PPAN Gene

Additional gene information for PPAN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPAN Gene

Genomics for PPAN Gene

GeneHancer (GH) Regulatory Elements for PPAN Gene

Promoters and enhancers for PPAN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I010100 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 599.1 -1.8 -1836 8.3 HDGF FOXA2 PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 PPAN ANGPTL6 PPAN-P2RY11 ZNF699 ILF3 LOC100419831 ZNF317 FBXL12 ZNF559 KRI1
GH19I010379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 67.7 +274.3 274304 1.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 TYK2 GC19P010382 ILF3 KRI1 FBXL12 DNMT1 PPAN RAVER1 LOC100419831 ZNF561
GH19I010415 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 35.8 +310.4 310423 2 CLOCK MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC PDE4A LOC100419831 ZNF266 KRI1 ILF3 RAVER1 FBXL12 PPAN ZNF561 DNMT1
GH19I010564 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 28.7 +461.2 461170 5.8 MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 KRI1 CDKN2D ILF3 RAVER1 FBXL12 PPAN CDC37 ZNF561 DNMT1 ZNF627
GH19I009620 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 29.1 -484.4 -484402 3.2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 ZNF561 ZNF561-AS1 ZNF266 KRI1 PPAN FBXL12 ZNF317 ZNF699 RAVER1 ZNF558
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPAN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPAN gene promoter:

Genomic Locations for PPAN Gene

Genomic Locations for PPAN Gene
chr19:10,106,223-10,111,634
(GRCh38/hg38)
Size:
5,412 bases
Orientation:
Plus strand
chr19:10,216,899-10,225,414
(GRCh37/hg19)

Genomic View for PPAN Gene

Genes around PPAN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPAN Gene

Proteins for PPAN Gene

  • Protein details for PPAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ55-SSF1_HUMAN
    Recommended name:
    Suppressor of SWI4 1 homolog
    Protein Accession:
    Q9NQ55
    Secondary Accessions:
    • C9J3F9
    • Q9BW97
    • Q9H170

    Protein attributes for PPAN Gene

    Size:
    473 amino acids
    Molecular mass:
    53194 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed:11278528).

    Alternative splice isoforms for PPAN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPAN Gene

Post-translational modifications for PPAN Gene

  • Ubiquitination at Lys212 and Lys217

No data available for DME Specific Peptides for PPAN Gene

Domains & Families for PPAN Gene

Gene Families for PPAN Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PPAN Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PPAN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPAN: view

No data available for UniProtKB/Swiss-Prot for PPAN Gene

Function for PPAN Gene

Molecular function for PPAN Gene

UniProtKB/Swiss-Prot Function:
May have a role in cell growth.

Phenotypes From GWAS Catalog for PPAN Gene

Gene Ontology (GO) - Molecular Function for PPAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22658674
GO:0019843 rRNA binding IBA --
genes like me logo Genes that share ontologies with PPAN: view

Phenotypes for PPAN Gene

GenomeRNAi human phenotypes for PPAN:
genes like me logo Genes that share phenotypes with PPAN: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPAN Gene

Localization for PPAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPAN Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPAN gene
Compartment Confidence
nucleus 5
extracellular 2

Gene Ontology (GO) - Cellular Components for PPAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15302935
GO:0005730 nucleolus IEA --
GO:0030687 preribosome, large subunit precursor IBA --
genes like me logo Genes that share ontologies with PPAN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPAN Gene

Pathways & Interactions for PPAN Gene

No Data Available

Interacting Proteins for PPAN Gene

Selected Interacting proteins: Q9NQ55-SSF1_HUMAN for PPAN Gene via IID

Gene Ontology (GO) - Biological Process for PPAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
genes like me logo Genes that share ontologies with PPAN: view

No data available for Pathways by source and SIGNOR curated interactions for PPAN Gene

Drugs & Compounds for PPAN Gene

No Compound Related Data Available

Transcripts for PPAN Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPAN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - -
SP6: - - -
SP7: -
SP8:
SP9:

Relevant External Links for PPAN Gene

GeneLoc Exon Structure for
PPAN
ECgene alternative splicing isoforms for
PPAN

Expression for PPAN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPAN Gene

Protein differential expression in normal tissues from HIPED for PPAN Gene

This gene is overexpressed in Lung (19.9), Peripheral blood mononuclear cells (12.8), Liver (9.0), and CD8 Tcells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPAN Gene



Protein tissue co-expression partners for PPAN Gene

NURSA nuclear receptor signaling pathways regulating expression of PPAN Gene:

PPAN

mRNA Expression by UniProt/SwissProt for PPAN Gene:

Q9NQ55-SSF1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PPAN Gene

  • Skin(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with PPAN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPAN Gene

Orthologs for PPAN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPAN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPAN 33 34
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia PPAN 33
  • 84.22 (n)
P2RY11 34
  • 81 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PPAN 33
  • 83.15 (n)
PPAN-P2RY11 34
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ppan 33 16 34
  • 79.69 (n)
rat
(Rattus norvegicus)
Mammalia Ppan 33
  • 79.09 (n)
oppossum
(Monodelphis domestica)
Mammalia PPAN 34
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PPAN 34
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 51 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ppan 33
  • 65.16 (n)
MGC76273 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7873 33
zebrafish
(Danio rerio)
Actinopterygii ppan 33 34
  • 63.27 (n)
Dr.15061 33
fruit fly
(Drosophila melanogaster)
Insecta ppan 35 33 34
  • 56.54 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004556 33
  • 48.41 (n)
worm
(Caenorhabditis elegans)
Secernentea lpd-6 34
  • 25 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL040W 33
  • 52.24 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C14586g 33
  • 47.26 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSF1 33 34
  • 45.59 (n)
SSF2 34
  • 32 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PPAN 33
  • 50.93 (n)
rice
(Oryza sativa)
Liliopsida Os03g0343700 33
  • 48.43 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04503 33
  • 52.4 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1B9.03c 33
  • 44.8 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2660 34
  • 41 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3479 33
Species where no ortholog for PPAN was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPAN Gene

ENSEMBL:
Gene Tree for PPAN (if available)
TreeFam:
Gene Tree for PPAN (if available)

Paralogs for PPAN Gene

Paralogs for PPAN Gene

genes like me logo Genes that share paralogs with PPAN: view

Variants for PPAN Gene

Sequence variations from dbSNP and Humsavar for PPAN Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs12460842 association, Cataplexy and narcolepsy 10,111,519(+) A/G downstream_transcript_variant
rs1551570 association, Cataplexy and narcolepsy 10,107,354(+) C/T intron_variant
rs1000302985 -- 10,109,677(+) C/G coding_sequence_variant, missense_variant
rs1000836315 -- 10,107,201(+) G/T intron_variant
rs1000867060 -- 10,105,519(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PPAN Gene

Variant ID Type Subtype PubMed ID
nsv833743 CNV loss 17160897

Variation tolerance for PPAN Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPAN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPAN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPAN Gene

Disorders for PPAN Gene

MalaCards: The human disease database

(4) MalaCards diseases for PPAN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
kummell's disease
  • kummell disease
enterocele
  • vaginal enterocele
prolapse of female genital organ
narcolepsy
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards
Search PPAN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PPAN

genes like me logo Genes that share disorders with PPAN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPAN Gene

Publications for PPAN Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 58
  3. Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes. (PMID: 11278528) Communi D … Boeynaems JM (The Journal of biological chemistry 2001) 3 4 58
  4. Identification and validation of a gene involved in anchorage-independent cell growth control using a library of randomized hairpin ribozymes. (PMID: 10873382) Welch PJ … Barber JR (Genomics 2000) 2 3 58
  5. Cloning, genomic organization, and tissue distribution of human Ssf-1. (PMID: 10944437) Suarez-Huerta N … Communi D (Biochemical and biophysical research communications 2000) 3 4 58

Products for PPAN Gene

Sources for PPAN Gene

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