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Aliases for PPAN Gene

Aliases for PPAN Gene

  • Peter Pan Homolog (Drosophila) 2 3 5
  • Brix Domain-Containing Protein 3 3 4
  • SSF-1 3 4
  • BXDC3 3 4
  • SSF1 3 4
  • Peter Pan (Drosophila) Homolog 2
  • Homolog Of S. Cerevisiae SSF1 3
  • Second-Step Splicing Factor 1 3
  • Suppressor Of SWI4 1 Homolog 3
  • Suppressor Of Sterile Four 1 3
  • Peter Pan Homolog 4
  • SSF2 3
  • SSF 3

External Ids for PPAN Gene

Previous GeneCards Identifiers for PPAN Gene

  • GC19P010338
  • GC19P010439
  • GC19P010062
  • GC19P010077
  • GC19P010216
  • GC19P009819

Summaries for PPAN Gene

Entrez Gene Summary for PPAN Gene

  • The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010]

GeneCards Summary for PPAN Gene

PPAN (Peter Pan Homolog (Drosophila)) is a Protein Coding gene. Diseases associated with PPAN include Kummell's Disease and Prolapse Of Female Genital Organ. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is PPAN-P2RY11.

UniProtKB/Swiss-Prot for PPAN Gene

  • May have a role in cell growth.

Gene Wiki entry for PPAN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPAN Gene

Genomics for PPAN Gene

Regulatory Elements for PPAN Gene

Enhancers for PPAN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F010192 1.4 FANTOM5 ENCODE 11.7 +88.1 88086 3.4 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 FBXL12 ZNF561 EIF3G UBE2L4 ENSG00000267510 LOC100128428 MIR1181 PPAN PPAN-P2RY11 ANGPTL6
GH19F010141 1.1 Ensembl ENCODE 12.5 +36.9 36885 2.2 CREB3L1 NFRKB ZNF48 ZNF335 ZNF121 ZNF766 PAF1 SMARCA5 MIER1 ZBTB11 C19orf66 ANGPTL6 EIF3G SNORD105B P2RY11 PPAN PPAN-P2RY11 SNORD105 RDH8 COL5A3
GH19F010197 1 Ensembl ENCODE 11.4 +93.5 93485 4.2 HDGF KLF1 ZMYM3 ZNF384 ZNF316 NFE2 MAFK SCRT1 ZNF362 L3MBTL2 C19orf66 ANGPTL6 S1PR2 MRPL4 ICAM1 EIF3G P2RY11 SNORD105B PPAN PPAN-P2RY11
GH19F010191 0.8 ENCODE 11.7 +85.3 85252 0.9 SAP130 ARID4B ZNF384 CEBPG ZNF644 RAD21 RARA TEAD3 ZNF121 ZNF335 PPAN PPAN-P2RY11 ANGPTL6 C19orf66 GC19M010177 LOC103689916
GH19F010071 0.6 ENCODE 11.9 -34.9 -34924 0.2 ATF3 GABPB1 ZBTB33 RAD21 NR2F2 YY1 ANGPTL6 PPAN PPAN-P2RY11 RDH8 COL5A3 EIF3G OLFM2 C19orf66 MIR5589
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPAN on UCSC Golden Path with GeneCards custom track

Promoters for PPAN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000343217 277 1401 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for PPAN Gene

Chromosome:
19
Start:
10,106,223 bp from pter
End:
10,111,634 bp from pter
Size:
5,412 bases
Orientation:
Plus strand

Genomic View for PPAN Gene

Genes around PPAN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPAN Gene

Proteins for PPAN Gene

  • Protein details for PPAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ55-SSF1_HUMAN
    Recommended name:
    Suppressor of SWI4 1 homolog
    Protein Accession:
    Q9NQ55
    Secondary Accessions:
    • C9J3F9
    • Q9BW97
    • Q9H170

    Protein attributes for PPAN Gene

    Size:
    473 amino acids
    Molecular mass:
    53194 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed:11278528).

    Alternative splice isoforms for PPAN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPAN Gene

Post-translational modifications for PPAN Gene

  • Ubiquitination at Lys 212 and Lys 217
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PPAN Gene

Domains & Families for PPAN Gene

Protein Domains for PPAN Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PPAN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQ55

UniProtKB/Swiss-Prot:

SSF1_HUMAN :
  • Contains 1 Brix domain.
Domain:
  • Contains 1 Brix domain.
genes like me logo Genes that share domains with PPAN: view

No data available for Gene Families for PPAN Gene

Function for PPAN Gene

Molecular function for PPAN Gene

UniProtKB/Swiss-Prot Function:
May have a role in cell growth.

Gene Ontology (GO) - Molecular Function for PPAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019843 rRNA binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PPAN: view

Phenotypes for PPAN Gene

GenomeRNAi human phenotypes for PPAN:
genes like me logo Genes that share phenotypes with PPAN: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPAN Gene

Localization for PPAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPAN Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPAN gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for PPAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15302935
GO:0005730 nucleolus IEA --
GO:0030687 preribosome, large subunit precursor IBA --
genes like me logo Genes that share ontologies with PPAN: view

Pathways & Interactions for PPAN Gene

No Data Available

Interacting Proteins for PPAN Gene

Selected Interacting proteins: Q9NQ55-SSF1_HUMAN for PPAN Gene via IID

Gene Ontology (GO) - Biological Process for PPAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
genes like me logo Genes that share ontologies with PPAN: view

No data available for Pathways by source and SIGNOR curated interactions for PPAN Gene

Transcripts for PPAN Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPAN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - -
SP6: - - -
SP7: -
SP8:
SP9:

Relevant External Links for PPAN Gene

GeneLoc Exon Structure for
PPAN
ECgene alternative splicing isoforms for
PPAN

Expression for PPAN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPAN Gene

Protein differential expression in normal tissues from HIPED for PPAN Gene

This gene is overexpressed in Lung (19.9), Peripheral blood mononuclear cells (12.8), Liver (9.0), and CD8 Tcells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPAN Gene



Protein tissue co-expression partners for PPAN Gene

NURSA nuclear receptor signaling pathways regulating expression of PPAN Gene:

PPAN

mRNA Expression by UniProt/SwissProt for PPAN Gene:

Q9NQ55-SSF1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with PPAN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPAN Gene

Orthologs for PPAN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPAN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPAN 34 35
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia PPAN 34
  • 84.22 (n)
P2RY11 35
  • 81 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PPAN 34
  • 83.15 (n)
PPAN-P2RY11 35
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ppan 34 16 35
  • 79.69 (n)
rat
(Rattus norvegicus)
Mammalia Ppan 34
  • 79.09 (n)
oppossum
(Monodelphis domestica)
Mammalia PPAN 35
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PPAN 35
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 51 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ppan 34
  • 65.16 (n)
MGC76273 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7873 34
zebrafish
(Danio rerio)
Actinopterygii ppan 34 35
  • 63.27 (n)
Dr.15061 34
fruit fly
(Drosophila melanogaster)
Insecta ppan 36 34 35
  • 56.54 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004556 34
  • 48.41 (n)
worm
(Caenorhabditis elegans)
Secernentea lpd-6 35
  • 25 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL040W 34
  • 52.24 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C14586g 34
  • 47.26 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSF1 34 35
  • 45.59 (n)
SSF2 35
  • 32 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PPAN 34
  • 50.93 (n)
rice
(Oryza sativa)
Liliopsida Os03g0343700 34
  • 48.43 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04503 34
  • 52.4 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1B9.03c 34
  • 44.8 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2660 35
  • 41 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3479 34
Species where no ortholog for PPAN was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPAN Gene

ENSEMBL:
Gene Tree for PPAN (if available)
TreeFam:
Gene Tree for PPAN (if available)

Paralogs for PPAN Gene

Paralogs for PPAN Gene

genes like me logo Genes that share paralogs with PPAN: view

Variants for PPAN Gene

Sequence variations from dbSNP and Humsavar for PPAN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12460842 other 10,111,519(+) GTCAC(A/G)CTTTC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1551570 other 10,107,354(+) TCCGA(C/T)TGACT intron-variant, upstream-variant-2KB
rs10421370 -- 10,104,631(+) GGAAC(C/T)ATGCT intron-variant, upstream-variant-2KB
rs111919173 -- 10,110,652(+) GGGGG(G/T)TCCCT intron-variant, upstream-variant-2KB
rs112367760 -- 10,111,308(+) CACGT(C/T)AGCGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PPAN Gene

Variant ID Type Subtype PubMed ID
nsv833743 CNV loss 17160897

Variation tolerance for PPAN Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPAN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPAN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPAN Gene

Disorders for PPAN Gene

MalaCards: The human disease database

(4) MalaCards diseases for PPAN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
kummell's disease
  • kummell disease
prolapse of female genital organ
enterocele
  • vaginal enterocele
narcolepsy
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards
Search PPAN in MalaCards View complete list of genes associated with diseases

Relevant External Links for PPAN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPAN
genes like me logo Genes that share disorders with PPAN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPAN Gene

Publications for PPAN Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4 64
  3. Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes. (PMID: 11278528) Communi D. … Boeynaems J.-M. (J. Biol. Chem. 2001) 3 4 64
  4. Identification and validation of a gene involved in anchorage-independent cell growth control using a library of randomized hairpin ribozymes. (PMID: 10873382) Welch P.J. … Barber J.R. (Genomics 2000) 2 3 64
  5. Cloning, genomic organization, and tissue distribution of human Ssf- 1. (PMID: 10944437) Suarez-Huerta N. … Communi D. (Biochem. Biophys. Res. Commun. 2000) 3 4 64

Products for PPAN Gene

Sources for PPAN Gene

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