Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPAN Gene

Aliases for PPAN Gene

  • Peter Pan Homolog (Drosophila) 2 3 5
  • Brix Domain-Containing Protein 3 3 4
  • SSF-1 3 4
  • BXDC3 3 4
  • SSF1 3 4
  • Peter Pan (Drosophila) Homolog 2
  • Homolog Of S. Cerevisiae SSF1 3
  • Second-Step Splicing Factor 1 3
  • Suppressor Of Sterile Four 1 3
  • Peter Pan Homolog 4
  • SSF2 3
  • SSF 3

External Ids for PPAN Gene

Previous GeneCards Identifiers for PPAN Gene

  • GC19P010338
  • GC19P010439
  • GC19P010062
  • GC19P010077
  • GC19P010216
  • GC19P009819

Summaries for PPAN Gene

Entrez Gene Summary for PPAN Gene

  • The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010]

GeneCards Summary for PPAN Gene

PPAN (Peter Pan Homolog (Drosophila)) is a Protein Coding gene. Diseases associated with PPAN include Kummell's Disease and Prolapse Of Female Genital Organ. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is PPAN-P2RY11.

UniProtKB/Swiss-Prot for PPAN Gene

  • May have a role in cell growth.

Gene Wiki entry for PPAN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPAN Gene

Genomics for PPAN Gene

Regulatory Elements for PPAN Gene

Enhancers for PPAN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPAN on UCSC Golden Path with GeneCards custom track

Promoters for PPAN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPAN on UCSC Golden Path with GeneCards custom track

Genomic Location for PPAN Gene

10,106,223 bp from pter
10,111,634 bp from pter
5,412 bases
Plus strand

Genomic View for PPAN Gene

Genes around PPAN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPAN Gene

Proteins for PPAN Gene

  • Protein details for PPAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Suppressor of SWI4 1 homolog
    Protein Accession:
    Secondary Accessions:
    • C9J3F9
    • Q9BW97
    • Q9H170

    Protein attributes for PPAN Gene

    473 amino acids
    Molecular mass:
    53194 Da
    Quaternary structure:
    No Data Available
    • A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed:11278528).

    Alternative splice isoforms for PPAN Gene


neXtProt entry for PPAN Gene

Proteomics data for PPAN Gene at MOPED

Post-translational modifications for PPAN Gene

  • Ubiquitination at Lys 212 and Lys 217
  • Modification sites at PhosphoSitePlus

Other Protein References for PPAN Gene

No data available for DME Specific Peptides for PPAN Gene

Domains & Families for PPAN Gene

Protein Domains for PPAN Gene


Suggested Antigen Peptide Sequences for PPAN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Brix domain.
  • Contains 1 Brix domain.
genes like me logo Genes that share domains with PPAN: view

No data available for Gene Families for PPAN Gene

Function for PPAN Gene

Molecular function for PPAN Gene

UniProtKB/Swiss-Prot Function:
May have a role in cell growth.

Gene Ontology (GO) - Molecular Function for PPAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PPAN: view

Phenotypes for PPAN Gene

GenomeRNAi human phenotypes for PPAN:
genes like me logo Genes that share phenotypes with PPAN: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPAN Gene

Localization for PPAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPAN Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for PPAN Gene COMPARTMENTS Subcellular localization image for PPAN gene
Compartment Confidence
nucleus 5
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for PPAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030687 preribosome, large subunit precursor IBA --
genes like me logo Genes that share ontologies with PPAN: view

Pathways & Interactions for PPAN Gene

SuperPathways for PPAN Gene

No Data Available

Interacting Proteins for PPAN Gene

Selected Interacting proteins: Q9NQ55-SSF1_HUMAN for PPAN Gene via I2D

Gene Ontology (GO) - Biological Process for PPAN Gene


No data available for Pathways by source and SIGNOR curated interactions for PPAN Gene

Drugs & Compounds for PPAN Gene

No Compound Related Data Available

Transcripts for PPAN Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PPAN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - -
SP6: - - -
SP7: -

Relevant External Links for PPAN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPAN Gene

mRNA expression in normal human tissues for PPAN Gene

Protein differential expression in normal tissues from HIPED for PPAN Gene

This gene is overexpressed in Lung (19.9), Peripheral blood mononuclear cells (12.8), Liver (9.0), and CD8 Tcells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PPAN Gene

mRNA Expression by UniProt/SwissProt for PPAN Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with PPAN: view

Protein tissue co-expression partners for PPAN Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPAN Gene

Orthologs for PPAN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPAN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPAN 35
  • 83.15 (n)
  • 80.65 (a)
PPAN-P2RY11 36
  • 75 (a)
(Canis familiaris)
Mammalia PPAN 35
  • 84.22 (n)
  • 85.51 (a)
P2RY11 36
  • 81 (a)
(Mus musculus)
Mammalia Ppan 35
  • 79.69 (n)
  • 78.35 (a)
Ppan 16
Ppan 36
  • 73 (a)
(Pan troglodytes)
Mammalia PPAN 35
  • 99.22 (n)
  • 99.37 (a)
  • 89 (a)
(Rattus norvegicus)
Mammalia Ppan 35
  • 79.09 (n)
  • 77.68 (a)
(Monodelphis domestica)
Mammalia PPAN 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia PPAN 36
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76273 35
ppan 35
  • 65.16 (n)
  • 63.01 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7873 35
(Danio rerio)
Actinopterygii Dr.15061 35
ppan 35
  • 63.27 (n)
  • 61.85 (a)
ppan 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta ppan 37
  • 37 (a)
ppan 35
  • 56.54 (n)
  • 43.82 (a)
ppan 36
  • 35 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004556 35
  • 48.41 (n)
  • 40.48 (a)
(Caenorhabditis elegans)
Secernentea lpd-6 36
  • 25 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL040W 35
  • 52.24 (n)
  • 40.06 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C14586g 35
  • 47.26 (n)
  • 42.09 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSF1 35
  • 45.59 (n)
  • 42.34 (a)
SSF1 36
  • 33 (a)
SSF2 36
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PPAN 35
  • 50.93 (n)
  • 45.72 (a)
(Oryza sativa)
Liliopsida Os03g0343700 35
  • 48.43 (n)
  • 40.77 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3479 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04503 35
  • 52.4 (n)
  • 42.81 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1B9.03c 35
  • 44.8 (n)
  • 40.17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2660 36
  • 41 (a)
Species with no ortholog for PPAN:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPAN Gene

Gene Tree for PPAN (if available)
Gene Tree for PPAN (if available)

Paralogs for PPAN Gene

Paralogs for PPAN Gene

genes like me logo Genes that share paralogs with PPAN: view

Variants for PPAN Gene

Sequence variations from dbSNP and Humsavar for PPAN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_022157 -
VAR_048422 -

Structural Variations from Database of Genomic Variants (DGV) for PPAN Gene

Variant ID Type Subtype PubMed ID
nsv833743 CNV Loss 17160897
nsv911028 CNV Loss 21882294

Variation tolerance for PPAN Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PPAN Gene

Disorders for PPAN Gene

MalaCards: The human disease database

(5) MalaCards diseases for PPAN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
kummell's disease
  • kummell disease
prolapse of female genital organ
  • vaginal enterocele
  • narcolepsy, without cataplexy
middle cerebral artery infarction
  • infarction middle cerebral artery
- elite association - COSMIC cancer census association via MalaCards
Search PPAN in MalaCards View complete list of genes associated with diseases

Relevant External Links for PPAN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PPAN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPAN Gene

Publications for PPAN Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Identification and validation of a gene involved in anchorage-independent cell growth control using a library of randomized hairpin ribozymes. (PMID: 10873382) Welch P.J. … Barber J.R. (Genomics 2000) 2 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway. (PMID: 25759387) Pfister A.S. … KA1hl M. (J. Biol. Chem. 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for PPAN Gene

Sources for PPAN Gene