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Aliases for PPAN Gene

Aliases for PPAN Gene

  • Peter Pan Homolog (Drosophila) 2 3 5
  • Brix Domain-Containing Protein 3 3 4
  • SSF-1 3 4
  • BXDC3 3 4
  • SSF1 3 4
  • Peter Pan (Drosophila) Homolog 2
  • Homolog Of S. Cerevisiae SSF1 3
  • Second-Step Splicing Factor 1 3
  • Suppressor Of SWI4 1 Homolog 3
  • Suppressor Of Sterile Four 1 3
  • Peter Pan Homolog 4
  • SSF2 3
  • SSF 3

External Ids for PPAN Gene

Previous GeneCards Identifiers for PPAN Gene

  • GC19P010338
  • GC19P010439
  • GC19P010062
  • GC19P010077
  • GC19P010216
  • GC19P009819

Summaries for PPAN Gene

Entrez Gene Summary for PPAN Gene

  • The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010]

GeneCards Summary for PPAN Gene

PPAN (Peter Pan Homolog (Drosophila)) is a Protein Coding gene. Diseases associated with PPAN include Kummell's Disease and Prolapse Of Female Genital Organ. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is PPAN-P2RY11.

UniProtKB/Swiss-Prot for PPAN Gene

  • May have a role in cell growth.

Gene Wiki entry for PPAN Gene

Additional gene information for PPAN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPAN Gene

Genomics for PPAN Gene

Regulatory Elements for PPAN Gene

Enhancers for PPAN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H010100 1.8 FANTOM5 ENCODE dbSUPER 64.7 -1.8 -1836 8.3 HDGF FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 ILF3 ZNF699 ZNF317 KRI1 FBXL12 LOC100419831 ZNF561 ZNF559 PPAN ZNF562
GH19H010379 1.1 ENCODE 71.8 +274.3 274304 1.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF207 ILF3 KRI1 FBXL12 PPAN RAVER1 DNMT1 LOC100419831 ZNF561 ZNF426 TIMM29
GH19H010285 1.6 Ensembl ENCODE dbSUPER 30.3 +183.5 183469 7.6 HNRNPUL1 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF143 ILF3 ZNF266 ZNF699 KRI1 ZNF559 LOC100419831 FBXL12 RAVER1 ZNF561 EIF3G
GH19H010415 1.5 FANTOM5 ENCODE 26.2 +310.4 310423 2 MLX DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 ZNF610 LOC100419831 ZNF266 ILF3 FBXL12 KRI1 DNMT1 PPAN RAVER1 ZNF426 ZNF561
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PPAN on UCSC Golden Path with GeneCards custom track

Promoters for PPAN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106954 377 1201 FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Locations for PPAN Gene

Genomic Locations for PPAN Gene
5,412 bases
Plus strand

Genomic View for PPAN Gene

Genes around PPAN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPAN Gene

Proteins for PPAN Gene

  • Protein details for PPAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Suppressor of SWI4 1 homolog
    Protein Accession:
    Secondary Accessions:
    • C9J3F9
    • Q9BW97
    • Q9H170

    Protein attributes for PPAN Gene

    473 amino acids
    Molecular mass:
    53194 Da
    Quaternary structure:
    No Data Available
    • A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed:11278528).

    Alternative splice isoforms for PPAN Gene


neXtProt entry for PPAN Gene

Post-translational modifications for PPAN Gene

  • Ubiquitination at Lys212 and posLast=217217
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PPAN Gene

Domains & Families for PPAN Gene

Gene Families for PPAN Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PPAN Gene


Suggested Antigen Peptide Sequences for PPAN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPAN: view

No data available for UniProtKB/Swiss-Prot for PPAN Gene

Function for PPAN Gene

Molecular function for PPAN Gene

UniProtKB/Swiss-Prot Function:
May have a role in cell growth.

Phenotypes From GWAS Catalog for PPAN Gene

Gene Ontology (GO) - Molecular Function for PPAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0019843 rRNA binding IBA --
genes like me logo Genes that share ontologies with PPAN: view

Phenotypes for PPAN Gene

GenomeRNAi human phenotypes for PPAN:
genes like me logo Genes that share phenotypes with PPAN: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPAN Gene

Localization for PPAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPAN Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPAN gene
Compartment Confidence
nucleus 5
extracellular 2

Gene Ontology (GO) - Cellular Components for PPAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15302935
GO:0005730 nucleolus IEA --
GO:0030687 preribosome, large subunit precursor IBA --
genes like me logo Genes that share ontologies with PPAN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPAN Gene

Pathways & Interactions for PPAN Gene

No Data Available

Interacting Proteins for PPAN Gene

Selected Interacting proteins: Q9NQ55-SSF1_HUMAN for PPAN Gene via IID

Gene Ontology (GO) - Biological Process for PPAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
genes like me logo Genes that share ontologies with PPAN: view

No data available for Pathways by source and SIGNOR curated interactions for PPAN Gene

Drugs & Compounds for PPAN Gene

No Compound Related Data Available

Transcripts for PPAN Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPAN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - -
SP6: - - -
SP7: -

Relevant External Links for PPAN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPAN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPAN Gene

Protein differential expression in normal tissues from HIPED for PPAN Gene

This gene is overexpressed in Lung (19.9), Peripheral blood mononuclear cells (12.8), Liver (9.0), and CD8 Tcells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPAN Gene

Protein tissue co-expression partners for PPAN Gene

NURSA nuclear receptor signaling pathways regulating expression of PPAN Gene:


mRNA Expression by UniProt/SwissProt for PPAN Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PPAN Gene

  • Skin(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with PPAN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPAN Gene

Orthologs for PPAN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPAN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPAN 33 34
  • 99.22 (n)
(Canis familiaris)
Mammalia PPAN 33
  • 84.22 (n)
P2RY11 34
  • 81 (a)
(Bos Taurus)
Mammalia PPAN 33
  • 83.15 (n)
PPAN-P2RY11 34
  • 75 (a)
(Mus musculus)
Mammalia Ppan 33 16 34
  • 79.69 (n)
(Rattus norvegicus)
Mammalia Ppan 33
  • 79.09 (n)
(Monodelphis domestica)
Mammalia PPAN 34
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia PPAN 34
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppan 33
  • 65.16 (n)
MGC76273 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7873 33
(Danio rerio)
Actinopterygii ppan 33 34
  • 63.27 (n)
Dr.15061 33
fruit fly
(Drosophila melanogaster)
Insecta ppan 35 33 34
  • 56.54 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004556 33
  • 48.41 (n)
(Caenorhabditis elegans)
Secernentea lpd-6 34
  • 25 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL040W 33
  • 52.24 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C14586g 33
  • 47.26 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSF1 33 34
  • 45.59 (n)
SSF2 34
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PPAN 33
  • 50.93 (n)
(Oryza sativa)
Liliopsida Os03g0343700 33
  • 48.43 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04503 33
  • 52.4 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1B9.03c 33
  • 44.8 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2660 34
  • 41 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3479 33
Species where no ortholog for PPAN was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPAN Gene

Gene Tree for PPAN (if available)
Gene Tree for PPAN (if available)

Paralogs for PPAN Gene

Paralogs for PPAN Gene

genes like me logo Genes that share paralogs with PPAN: view

Variants for PPAN Gene

Sequence variations from dbSNP and Humsavar for PPAN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12460842 other 10,111,519(+) GTCAC(A/G)CTTTC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1551570 other 10,107,354(+) TCCGA(C/T)TGACT intron-variant, upstream-variant-2KB
rs1000302985 -- 10,109,677(+) CAACC(C/G)CGACT upstream-variant-2KB, reference, missense
rs1000836315 -- 10,107,201(+) GACTA(G/T)AATCT intron-variant, upstream-variant-2KB
rs1000867060 -- 10,105,519(+) AGGAA(A/G)CTTCT intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PPAN Gene

Variant ID Type Subtype PubMed ID
nsv833743 CNV loss 17160897

Variation tolerance for PPAN Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPAN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPAN Gene

Disorders for PPAN Gene

MalaCards: The human disease database

(5) MalaCards diseases for PPAN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
kummell's disease
  • kummell disease
prolapse of female genital organ
  • vaginal enterocele
neurodegeneration with brain iron accumulation 4
  • mitochondrial protein-associated neurodegeneration
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards
Search PPAN in MalaCards View complete list of genes associated with diseases

Relevant External Links for PPAN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PPAN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPAN Gene

Publications for PPAN Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 60
  3. Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes. (PMID: 11278528) Communi D … Boeynaems JM (The Journal of biological chemistry 2001) 3 4 60
  4. Identification and validation of a gene involved in anchorage-independent cell growth control using a library of randomized hairpin ribozymes. (PMID: 10873382) Welch PJ … Barber JR (Genomics 2000) 2 3 60
  5. Cloning, genomic organization, and tissue distribution of human Ssf-1. (PMID: 10944437) Suarez-Huerta N … Communi D (Biochemical and biophysical research communications 2000) 3 4 60

Products for PPAN Gene

Sources for PPAN Gene

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