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Aliases for PPA1 Gene

Aliases for PPA1 Gene

  • Pyrophosphatase (Inorganic) 1 2 3 5
  • Pyrophosphate Phospho-Hydrolase 2 3 4
  • Cytosolic Inorganic Pyrophosphatase 2 3
  • Inorganic Pyrophosphatase 1 2 3
  • Inorganic Diphosphatase 1 2 3
  • EC 3.6.1.1 4 63
  • IOPPP 3 4
  • PPase 3 4
  • PP 3 4
  • Epididymis Secretory Sperm Binding Protein Li 66p 3
  • Diphosphate Phosphohydrolase 3
  • Pyrophosphatase (Inorganic) 2
  • Inorganic Diphosphatase 3
  • Pyrophosphatase 1 3
  • HEL-S-66p 3
  • SID6-8061 3
  • PP1 3

External Ids for PPA1 Gene

Previous HGNC Symbols for PPA1 Gene

  • PP

Previous GeneCards Identifiers for PPA1 Gene

  • GC10M071633
  • GC10M071962
  • GC10M065955

Summaries for PPA1 Gene

Entrez Gene Summary for PPA1 Gene

  • The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPA1 Gene

PPA1 (Pyrophosphatase (Inorganic) 1) is a Protein Coding gene. Diseases associated with PPA1 include Baylisascariasis. Among its related pathways are tRNA Aminoacylation and Gene Expression. GO annotations related to this gene include magnesium ion binding and inorganic diphosphatase activity. An important paralog of this gene is PPA2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPA1 Gene

Genomics for PPA1 Gene

Regulatory Elements for PPA1 Gene

Enhancers for PPA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PPA1 on UCSC Golden Path with GeneCards custom track

Promoters for PPA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PPA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PPA1 Gene

Chromosome:
10
Start:
70,202,830 bp from pter
End:
70,233,911 bp from pter
Size:
31,082 bases
Orientation:
Minus strand

Genomic View for PPA1 Gene

Genes around PPA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPA1 Gene

Proteins for PPA1 Gene

  • Protein details for PPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15181-IPYR_HUMAN
    Recommended name:
    Inorganic pyrophosphatase
    Protein Accession:
    Q15181
    Secondary Accessions:
    • Q2M348
    • Q5SQT7
    • Q6P7P4
    • Q9UQJ5
    • Q9Y5B1

    Protein attributes for PPA1 Gene

    Size:
    289 amino acids
    Molecular mass:
    32660 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.

neXtProt entry for PPA1 Gene

Proteomics data for PPA1 Gene at MOPED

Post-translational modifications for PPA1 Gene

  • Ubiquitination at Lys 25, Lys 70, Lys 128, Lys 176, Lys 179, Lys 238, and Lys 253
  • Modification sites at PhosphoSitePlus

Other Protein References for PPA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PPA1 (Inorganic Pyrophosphatase/PPA1)
  • Abcam antibodies for HRC

Domains & Families for PPA1 Gene

Protein Domains for PPA1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15181

UniProtKB/Swiss-Prot:

IPYR_HUMAN :
  • Belongs to the PPase family.
Family:
  • Belongs to the PPase family.
genes like me logo Genes that share domains with PPA1: view

No data available for Gene Families for PPA1 Gene

Function for PPA1 Gene

Molecular function for PPA1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Diphosphate + H(2)O = 2 phosphate.

Enzyme Numbers (IUBMB) for PPA1 Gene

Gene Ontology (GO) - Molecular Function for PPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
genes like me logo Genes that share ontologies with PPA1: view
genes like me logo Genes that share phenotypes with PPA1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PPA1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPA1 Gene

Localization for PPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPA1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PPA1 Gene COMPARTMENTS Subcellular localization image for PPA1 gene
Compartment Confidence
cytosol 5
extracellular 5
vacuole 3
mitochondrion 2
nucleus 2
plasma membrane 2
chloroplast 1
cytoskeleton 1
golgi apparatus 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,TAS 16130169
genes like me logo Genes that share ontologies with PPA1: view

Pathways & Interactions for PPA1 Gene

genes like me logo Genes that share pathways with PPA1: view

Pathways by source for PPA1 Gene

1 BioSystems pathway for PPA1 Gene
1 KEGG pathway for PPA1 Gene

Gene Ontology (GO) - Biological Process for PPA1 Gene

None

No data available for SIGNOR curated interactions for PPA1 Gene

Drugs & Compounds for PPA1 Gene

(23) Drugs for PPA1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diphosphate Experimental Pharma 0
Magnesium Nutra 0

(21) Additional Compounds for PPA1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PPA1: view

Transcripts for PPA1 Gene

Unigene Clusters for PPA1 Gene

Pyrophosphatase (inorganic) 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPA1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: -
SP3: - - - -
SP4:
SP5: - -
SP6:

Relevant External Links for PPA1 Gene

GeneLoc Exon Structure for
PPA1
ECgene alternative splicing isoforms for
PPA1

Expression for PPA1 Gene

mRNA expression in normal human tissues for PPA1 Gene

Protein differential expression in normal tissues from HIPED for PPA1 Gene

This gene is overexpressed in Retina (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPA1 Gene



SOURCE GeneReport for Unigene cluster for PPA1 Gene Hs.437403

mRNA Expression by UniProt/SwissProt for PPA1 Gene

Q15181-IPYR_HUMAN
Tissue specificity: Expressed ubiquitously.
genes like me logo Genes that share expression patterns with PPA1: view

Protein tissue co-expression partners for PPA1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPA1 Gene

Orthologs for PPA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPA1 35
  • 92.16 (n)
  • 95.16 (a)
PPA1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPA1 35
  • 92.27 (n)
  • 94.44 (a)
PPA1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppa1 35
  • 88.24 (n)
  • 94.12 (a)
Ppa1 16
Ppa1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPA1 35
  • 99.65 (n)
  • 99.31 (a)
PPA1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppa1 35
  • 87.89 (n)
  • 92.39 (a)
oppossum
(Monodelphis domestica)
Mammalia PPA1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPA1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPA1 35
  • 75 (n)
  • 78.12 (a)
PPA1 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPA1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppa2 35
  • 72.49 (n)
  • 70.98 (a)
Str.15980 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.10406 35
zebrafish
(Danio rerio)
Actinopterygii ppa1b 35
  • 69.82 (n)
  • 73.68 (a)
zgc73156 35
ppa1a 36
  • 64 (a)
OneToMany
ppa1b 36
  • 71 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10308 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003398 35
  • 56.12 (n)
  • 59.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nurf-38 35
  • 54.82 (n)
  • 55.75 (a)
Nurf-38 36
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pyp-1 35
  • 60.93 (n)
  • 56.04 (a)
pyp-1 36
  • 35 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER015C 35
  • 53.31 (n)
  • 52.35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17667g 35
  • 58 (n)
  • 52.71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IPP1 35
  • 58.67 (n)
  • 54.91 (a)
IPP1 36
  • 53 (a)
OneToMany
IPP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PPa6 35
  • 57.86 (n)
  • 50.65 (a)
rice
(Oryza sativa)
Liliopsida Os02g0768600 35
  • 53.39 (n)
  • 49.78 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00951 35
  • 54.15 (n)
  • 52.71 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC23C11.05 35
  • 54.92 (n)
  • 50.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10318 36
  • 58 (a)
OneToMany
Species with no ortholog for PPA1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPA1 Gene

ENSEMBL:
Gene Tree for PPA1 (if available)
TreeFam:
Gene Tree for PPA1 (if available)

Paralogs for PPA1 Gene

Paralogs for PPA1 Gene

(1) SIMAP similar genes for PPA1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for PPA1 Gene

genes like me logo Genes that share paralogs with PPA1: view

Variants for PPA1 Gene

Sequence variations from dbSNP and Humsavar for PPA1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_036358 A breast cancer sample
rs9335 -- 70,202,999(+) GATGG(A/G)TAACA utr-variant-3-prime
rs1931554 -- 70,218,152(-) TAAAT(A/G)TTCTT intron-variant
rs3969945 -- 70,210,503(+) GTACA(A/G)GCACT intron-variant
rs2151833 -- 70,216,897(-) CCACC(A/G)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPA1 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV Gain+Loss 17666407
nsv831908 CNV Gain 17160897

Variation tolerance for PPA1 Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PPA1 Gene

Disorders for PPA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPA1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
baylisascariasis
  • infection by baylisascaris
- elite association - COSMIC cancer census association via MalaCards
Search PPA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PPA1

Genetic Association Database (GAD)
PPA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PPA1
genes like me logo Genes that share disorders with PPA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPA1 Gene

Publications for PPA1 Gene

  1. Cloning and expression profile of human inorganic pyrophosphatase. (PMID: 10542310) Fairchild T.A. … Patejunas G. (Biochim. Biophys. Acta 1999) 2 3 4 23 67
  2. Assignment of the inorganic pyrophosphatase gene locus (PP) to chromosome 10 in man. (PMID: 975879) McAlpine P.J. … Hamerton J.L. (Cytogenet. Cell Genet. 1976) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PPA1 Gene

Sources for PPA1 Gene

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