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Aliases for PPA1 Gene

Aliases for PPA1 Gene

  • Pyrophosphatase (Inorganic) 1 2 3
  • Pyrophosphate Phospho-Hydrolase 2 3 4
  • Cytosolic Inorganic Pyrophosphatase 2 3
  • Inorganic Pyrophosphatase 1 2 3
  • EC 4 63
  • IOPPP 3 4
  • PPase 3 4
  • PP 3 4
  • Epididymis Secretory Sperm Binding Protein Li 66p 3
  • Diphosphate Phosphohydrolase 3
  • Pyrophosphatase (Inorganic) 2
  • Inorganic Diphosphatase 3
  • Pyrophosphatase 1 3
  • HEL-S-66p 3
  • SID6-8061 3
  • PP1 3

External Ids for PPA1 Gene

Previous HGNC Symbols for PPA1 Gene

  • PP

Previous GeneCards Identifiers for PPA1 Gene

  • GC10M071633
  • GC10M071962
  • GC10M065955

Summaries for PPA1 Gene

Entrez Gene Summary for PPA1 Gene

  • The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPA1 Gene

PPA1 (Pyrophosphatase (Inorganic) 1) is a Protein Coding gene. Diseases associated with PPA1 include baylisascariasis. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include magnesium ion binding and inorganic diphosphatase activity. An important paralog of this gene is PPA2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPA1 Gene

Genomics for PPA1 Gene

Regulatory Elements for PPA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PPA1 Gene

70,202,830 bp from pter
70,233,911 bp from pter
31,082 bases
Minus strand

Genomic View for PPA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPA1 Gene

Proteins for PPA1 Gene

  • Protein details for PPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inorganic pyrophosphatase
    Protein Accession:
    Secondary Accessions:
    • Q2M348
    • Q5SQT7
    • Q6P7P4
    • Q9UQJ5
    • Q9Y5B1

    Protein attributes for PPA1 Gene

    289 amino acids
    Molecular mass:
    32660 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 4 Mg(2+) ions per subunit. Other metal ions can support activity, but at a lower rate. Two Mg(2+) ions are required for the activation of the enzyme and are present before substrate binds, two additional Mg(2+) ions form complexes with substrate and product.;
    Quaternary structure:
    • Homodimer.

neXtProt entry for PPA1 Gene

Proteomics data for PPA1 Gene at MOPED

Post-translational modifications for PPA1 Gene

  • Ubiquitination at Lys 25, Lys 70, Lys 128, Lys 176, Lys 179, Lys 238, and Lys 253
  • Modification sites at PhosphoSitePlus

Other Protein References for PPA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PPA1 (Inorganic Pyrophosphatase/PPA1)

Domains & Families for PPA1 Gene

Protein Domains for PPA1 Gene


Suggested Antigen Peptide Sequences for PPA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PPase family.
  • Belongs to the PPase family.
genes like me logo Genes that share domains with PPA1: view

No data available for Gene Families for PPA1 Gene

Function for PPA1 Gene

Molecular function for PPA1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Diphosphate + H(2)O = 2 phosphate

Enzyme Numbers (IUBMB) for PPA1 Gene

Gene Ontology (GO) - Molecular Function for PPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004427 inorganic diphosphatase activity EXP --
GO:0016462 pyrophosphatase activity --
genes like me logo Genes that share ontologies with PPA1: view
genes like me logo Genes that share phenotypes with PPA1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPA1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PPA1 Gene

Localization for PPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPA1 Gene


Subcellular locations from

Jensen Localization Image for PPA1 Gene COMPARTMENTS Subcellular localization image for PPA1 gene
Compartment Confidence
extracellular 5
cytosol 4
vacuole 3
mitochondrion 2
plasma membrane 2
chloroplast 1
cytoskeleton 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 16130169
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with PPA1: view

Pathways & Interactions for PPA1 Gene

genes like me logo Genes that share pathways with PPA1: view

Pathways by source for PPA1 Gene

1 BioSystems pathway for PPA1 Gene
1 KEGG pathway for PPA1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for PPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006796 phosphate-containing compound metabolic process IEA --
GO:0010467 gene expression TAS --
GO:0071344 diphosphate metabolic process TAS --
genes like me logo Genes that share ontologies with PPA1: view

No data available for SIGNOR curated interactions for PPA1 Gene

Drugs & Compounds for PPA1 Gene

(23) Drugs for PPA1 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dopamine Approved Pharma Full agonist, Agonist 2814
Nitric Oxide Approved Pharma 540
spermine Approved Nutra Channel blocker 0
Vitamin C Approved Nutra 398,398
Diphosphate Experimental Pharma 0

(21) Additional Compounds for PPA1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
12-O-Tetradecanoylphorbol 13-acetate
alpha tocopherol
genes like me logo Genes that share compounds with PPA1: view

Transcripts for PPA1 Gene

Unigene Clusters for PPA1 Gene

Pyrophosphatase (inorganic) 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PPA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPA1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: -
SP3: - - - -
SP5: - -

Relevant External Links for PPA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPA1 Gene

mRNA expression in normal human tissues for PPA1 Gene

Protein differential expression in normal tissues from HIPED for PPA1 Gene

This gene is overexpressed in Retina (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPA1 Gene

SOURCE GeneReport for Unigene cluster for PPA1 Gene Hs.437403

mRNA Expression by UniProt/SwissProt for PPA1 Gene

Tissue specificity: Expressed ubiquitously.
genes like me logo Genes that share expression patterns with PPA1: view

Protein tissue co-expression partners for PPA1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PPA1 Gene

Orthologs for PPA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPA1 35
  • 92.16 (n)
  • 95.16 (a)
PPA1 36
  • 95 (a)
(Canis familiaris)
Mammalia PPA1 35
  • 92.27 (n)
  • 94.44 (a)
PPA1 36
  • 95 (a)
(Mus musculus)
Mammalia Ppa1 35
  • 88.24 (n)
  • 94.12 (a)
Ppa1 16
Ppa1 36
  • 94 (a)
(Pan troglodytes)
Mammalia PPA1 35
  • 99.65 (n)
  • 99.31 (a)
PPA1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ppa1 35
  • 87.89 (n)
  • 92.39 (a)
(Monodelphis domestica)
Mammalia PPA1 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia PPA1 36
  • 80 (a)
(Gallus gallus)
Aves PPA1 35
  • 75 (n)
  • 78.12 (a)
PPA1 36
  • 73 (a)
(Anolis carolinensis)
Reptilia PPA1 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppa2 35
  • 72.49 (n)
  • 70.98 (a)
Str.15980 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.10406 35
(Danio rerio)
Actinopterygii ppa1b 35
  • 69.82 (n)
  • 73.68 (a)
zgc73156 35
ppa1a 36
  • 64 (a)
ppa1b 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10308 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003398 35
  • 56.12 (n)
  • 59.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nurf-38 35
  • 54.82 (n)
  • 55.75 (a)
Nurf-38 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea pyp-1 35
  • 60.93 (n)
  • 56.04 (a)
pyp-1 36
  • 35 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER015C 35
  • 53.31 (n)
  • 52.35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17667g 35
  • 58 (n)
  • 52.71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IPP1 35
  • 58.67 (n)
  • 54.91 (a)
IPP1 36
  • 53 (a)
IPP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PPa6 35
  • 57.86 (n)
  • 50.65 (a)
(Oryza sativa)
Liliopsida Os02g0768600 35
  • 53.39 (n)
  • 49.78 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00951 35
  • 54.15 (n)
  • 52.71 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC23C11.05 35
  • 54.92 (n)
  • 50.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10318 36
  • 58 (a)
Species with no ortholog for PPA1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPA1 Gene

Gene Tree for PPA1 (if available)
Gene Tree for PPA1 (if available)

Paralogs for PPA1 Gene

Paralogs for PPA1 Gene

(1) SIMAP similar genes for PPA1 Gene using alignment to 2 proteins: Pseudogenes for PPA1 Gene

genes like me logo Genes that share paralogs with PPA1: view

Variants for PPA1 Gene

Sequence variations from dbSNP and Humsavar for PPA1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs9335 -- 70,202,999(+) GATGG(A/G)TAACA utr-variant-3-prime
rs1134698 -- 70,229,976(-) agccg(A/G)gatgg intron-variant
rs1931554 -- 70,218,152(-) TAAAT(A/G)TTCTT intron-variant
rs2151833 -- 70,216,897(-) CCACC(A/G)TGTCT intron-variant
rs2151834 -- 70,213,072(-) ATTGC(A/G)GAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPA1 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV Gain+Loss 17666407
nsv831908 CNV Gain 17160897

Variation tolerance for PPA1 Gene

Residual Variation Intolerance Score: 36.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PPA1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPA1 Gene

Disorders for PPA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPA1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • infection by baylisascaris
- elite association
Search PPA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PPA1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PPA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPA1 Gene

Publications for PPA1 Gene

  1. Cloning and expression profile of human inorganic pyrophosphatase. (PMID: 10542310) Fairchild T.A. … Patejunas G. (Biochim. Biophys. Acta 1999) 2 23 67
  2. Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells. (PMID: 19281832) Luo S.F. … Yang C.M. (Toxicol. Appl. Pharmacol. 2009) 23 67
  3. Structural and kinetic features of family I inorganic pyrophosphatase from Vibrio cholerae. (PMID: 19747093) Rodina E.V. … Nazarova T.I. (Biochemistry Mosc. 2009) 23 67
  4. Estrogen receptor-independent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activation. (PMID: 18089844) Yi K.D. … Simpkins J.W. (J. Pharmacol. Exp. Ther. 2008) 23 67
  5. Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly. (PMID: 18426974) Emanuele M.J. … Stukenberg P.T. (J. Cell Biol. 2008) 23 67

Products for PPA1 Gene

Sources for PPA1 Gene

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