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SLC43A1 Gene

protein-coding   GIFtS: 51

GC11M057008
solute carrier family 43, member 1
(Previous name: prostate cancer overexpressed gene 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: POV1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
LAT3 2, 3, 5
PB39 1, 2, 3
POV1 2, 3, 5
R00504 1, 2
Descriptions
L-type amino acid transporter 3 2, 3
Prostate cancer overexpressed gene 1 protein 3
Solute carrier family 43 member 1 3
prostate cancer overexpressed gene 1 1, 2
solute carrier family 43, member 1 2
External Ids
HGNC: 92251
Entrez Gene: 85012
UniProtKB: O753873
Ensembl: ENSG000001491507
Search outside databases for aliases for SLC43A1 gene

Previous GC identifers: GC11M057502 GC11M057027

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SLC43A1:
SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large
neutral amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM]

UniProtKB/Swiss-Prot: LAT3_HUMAN, O75387
Function: Sodium-independent, high affinity transport of large neutral amino acids. Has narrower
substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino
acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic
intraepithelial neoplasia to invasive prostate cancer

Gene Wiki entry for SLC43A1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SLC43A1 gene  

Entrez Gene cytogenetic band: 11p11.2-p11.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

SLC43A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057008:     (about GC identifiers)

Start:
57,008,583 bp from pter
End:
57,039,735 bp from pter
Size:
31,153 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000011.8  NT_033903.7  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: LAT3_HUMAN, O75387 (See protein sequence)
Recommended Name: Large neutral amino acids transporter small subunit 3  
Size: 559 amino acids; 61477 Da
Subcellular location: Membrane; Multi-pass membrane protein (Probable)
Miscellaneous: Up-regulated in early prostate cancer development with highest expression level in
seminomas of testicular germ cell tumors
Alternative splicing: 2 isoforms:  O75387-1   O75387-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_003618.1  

    ENSEMBL proteins: 
    ENSP00000278426 


    Human Recombinant Proteins 
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    Browse R&D Systems for human recombinant proteins
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    Recombinant Proteins from Abcam (LAT3)
    Human Recombinant Proteins from Abnova (SLC43A1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887 integral to plasma membrane TAS12930836
    GO:0016020 membrane IEA--
    About this table

    Antibodies for SLC43A1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for SLC43A1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (LAT3), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for SLC43A1

    Assays for SLC43A1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: O75387

    UniProtKB/Swiss-Prot: LAT3_HUMAN, O75387
    Similarity: Belongs to the SLC43A transporter (TC 2.A.1.44) family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (SLC43A1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (SLC43A1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003627

                  Applied Biosystems Silencer® siRNAs for SLC43A1

                  Sigma-Aldrich siRNA and siRNA Panels for SLC43A1  
                         Sigma-Aldrich shRNA for SLC43A1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for SLC43A1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003627
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003627
                                     untagged cDNA clone in CMV expression vector: NM_003627 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_003627

    UniProtKB/Swiss-Prot: LAT3_HUMAN, O75387
    Function: Sodium-independent, high affinity transport of large neutral amino acids. Has narrower
    substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino
    acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic
    intraepithelial neoplasia to invasive prostate cancer

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015175 neutral amino acid transmembrane transporter activity IDA12930836
    GO:0015179 L-amino acid transmembrane transporter activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810 transport IEA--
    GO:0015804 neutral amino acid transport IDA12930836
    GO:0015807 L-amino acid transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for SLC43A1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (SLC43A1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (SLC43A1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003627

                  Sigma-Aldrich siRNA and siRNA Panels for SLC43A1  
                         Sigma-Aldrich shRNA for SLC43A1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_003627  

    REFSEQ mRNAs for SLC43A1 gene: 

    NM_003627.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_003627  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003627
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003627
                                     untagged cDNA clone in CMV expression vector: NM_003627 

    Additional cDNA sequence: 

    AB103033.1 AF045584.1 AK027732.1 BC001639.2 CR606379.1 

    12 DOTS entries:

    DT.415269  DT.102827623  DT.75120558  DT.40123707  DT.95364920  DT.92429257  DT.40109130  DT.75153345 
    DT.92414849  DT.95088669  DT.95100065  DT.95346861 

    24/114 AceView cDNA sequences (see all 114 ):

    AI567334 BM451394 BQ029981 BQ049835 CO250090 BG397532 CR606379 AI859012 
    AK027732 BQ227946 AA345572 BX494561 BU182024 AB103033 BQ678583 BC001639 
    AA447955 BE396312 BF801187 AA040486 BX956133 NM_003627 BE293435 BI906713 

    highest scoring ESTs for SLC43A1:

    AB103033 AF045584 BX956133 CO250090 AA040589 AA136451 AA177117 AA251114 AA255667 AA345572 

    Unigene Cluster for SLC43A1:

    Solute carrier family 43, member 1
    Hs.591952  [show with all ESTs]
    Unigene Representative Sequence: NM_003627


    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SLC43A1 (see all 12 )

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:              -     -     -     -           -                                   -                 -     -     -                                             
    SP2:                                -           -                                   -                 -     -     -                                             
    SP3:                                            -                 -     -     -     -     -     -     -     -     -     -     -                                 
    SP4:                                                                                -     -     -     -     -     -     -     -     -     -     -               
    SP5:              -     -     -     -                                               -                                                                           

    ExUns: 21a · 21b · 21c ^ 22
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        

    About this scheme

    ECgene alternative splicing isoforms for SLC43A1

    1 Ensembl transcript including schematic representation:
    ENST00000278426  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    SLC43A1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for SLC43A1

    1 / 2 / 3

    3 probe-sets matching SLC43A1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33708_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AF045584 0.80 1.00 0.91 1

    204394_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003627 0.60 1.00 0.82 1

    204394_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  SLC43A1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TGTCTGTGTA

    SOURCE GeneReport for Unigene cluster: Hs.591952

    Expression variation in blood from EXPOLDB for SLC43A1

    UniProtKB/Swiss-Prot: LAT3_HUMAN, O75387
    Tissue specificity: In adults, found in all tissues examined with highest expression in pancreas.
    In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in
    prostate cancer cells

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for SLC43A1 gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SLC43A11   -- solute carrier family 43, member 1 88.77(n)
    87.46(a)
    483493  XM_540611.2  XP_540611.2 
    rat
    (Rattus norvegicus)
    Slc43a11   -- solute carrier family 43, member 1 84.05(n)
    83.99(a)
    311168  XM_230050.3  XP_230050.4 
    mouse
    (Mus musculus)
    Slc43a11, 5 25
    solute carrier family 43, member 11, 5 84.2(n)1
    83.84(a)1
    724011  NM_001083809.11  NP_001077278.11 
     AA1046605  AA9861415  (see all 20)
    zebrafish
    (Danio rerio)
    wufi47a122   -- wufi47a12 76.32(n) 334395  BC044509.1 
    tropical clawed frog
    (Silurana tropicalis)
    1377176962   --   -- 71.04(n)  137717696 
    About this table        Species with no ortholog for SLC43A1

    ENSEMBL Gene Tree for SLC43A1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for SLC43A1 gene
    SLC43A32  SLC43A22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/169 NCBI SNPs in SLC43A1 are shown (see all 169 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 36)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs28486341,2
    A,C,F,H57008904(+) AAGAAA/GGCTCA 1 -- ut31 trp312Minor allele frequency- G:0.19EU EA WA NA 1192
    rs26496661,2
    A,C,F57039632(-) GTGGCG/CGCCGG 1 -- ut51 ese33Minor allele frequency- C:0.44NA 126
    rs347461071,2
    C,F57013308(+) GAGGTG/ATAAGT 1 Y/H mis15Minor allele frequency- A:0.00NA EU EA WA 498
    rs101607971,2
    F,H57041291(+) TTCTCG/AGTGGC 1 -- ng31 tfbs34Minor allele frequency- A:0.02EU EA WA 412
    --
    rs28486261,2
    C,F57040564(+) caccaT/Cggcat 1 -- ng313Minor allele frequency- C:0.06NA 138
    --
    rs79397451,2
    A57040644(+) TTTTTA/TAAAAA 1 -- ng31 trp30--------
    rs171519331,2
    H57018200(+) CCAGCC/ACACTC 1 V/G mis1 ese37Minor allele frequency- A:0.00NA EU EA WA 560
    --
    rs25819221,2
    A,C,F,H,O57021976(+) ATAGCC/TCCAGG 1 -- int18Minor allele frequency- N:0.01EU EA WA NA 620
    rs38511181,2
    A,C,F,H57037527(+) GAGACT/CCTCCA 1 -- int112Minor allele frequency- C:0.33EU EA WA NA 1044
    rs79346261,2
    A,C,F,H57030690(+) CCACAC/TTATTC 1 -- int17Minor allele frequency- T:0.13EU EA WA NA 556
    About this table

    HapMap Linkage Disequilibrium images for SLC43A1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 603733

    3 Novoseek disease relationships for SLC43A1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    seminoma 64.80 2 16115909 (1), 14612934 (1)
    prostate cancer 27.79 6 9722952 (3), 14612934 (1)
    tumors 2.44 1 9722952 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/12 PubMed articles for SLC43A1 gene (see all 12 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 8501 HGNC: 9225 AceView: SLC43A1 Ensembl:ENSG00000149150 euGenes: HUgn8501
    ECgene: SLC43A1 H-InvDB: SLC43A1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for SLC43A1 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for SLC43A1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for SLC43A1 Antibodies for SLC43A1
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