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Aliases & Descriptions for SLC43A1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| L-type amino acid transporter 3 2, 3 | | Prostate cancer overexpressed gene 1 protein 3 | | Solute carrier family 43 member 1 3 | | prostate cancer overexpressed gene 1 1, 2 | | solute carrier family 43, member 1 2 |
|
| | Search outside databases for aliases for SLC43A1 genePrevious GC identifers: GC11M057502 GC11M057027 |
Summaries for SLC43A1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for SLC43A1: SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM] UniProtKB/Swiss-Prot: LAT3_HUMAN, O75387Function: Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancerGene Wiki entry for SLC43A1 |
Genomic Location for SLC43A1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the SLC43A1 gene 
Entrez Gene cytogenetic band: 11p11.2-p11.1 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q12.1SLC43A1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M057008:
(about GC identifiers)
Start:
|
57,008,583 bp from pter |
End:
|
57,039,735 bp from pter |
Size:
|
31,153 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000011.8 NT_033903.7
| Proteins for SLC43A1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LAT3_HUMAN, O75387 (See
protein sequence)Recommended Name: Large neutral amino acids transporter small subunit 3 Size: 559 amino acids; 61477 Da
Subcellular location: Membrane; Multi-pass membrane protein (Probable)
Miscellaneous: Up-regulated in early prostate cancer development with highest expression level in seminomas of testicular germ cell tumorsAlternative splicing: 2 isoforms: O75387-1 O75387-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003618.1
ENSEMBL proteins: ENSP00000278426
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for SLC43A1: Assays for SLC43A1: | Protein
Domains/ Families for SLC43A1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: O75387 UniProtKB/Swiss-Prot: LAT3_HUMAN, O75387Similarity: Belongs to the SLC43A transporter (TC 2.A.1.44) family | Gene Function for SLC43A1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003627
Applied Biosystems Silencer® siRNAs for SLC43A1
Sigma-Aldrich siRNA and siRNA Panels for SLC43A1  Sigma-Aldrich shRNA for SLC43A1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003627                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003627                                  untagged cDNA clone in CMV expression vector: NM_003627 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003627
UniProtKB/Swiss-Prot: LAT3_HUMAN, O75387Function: Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015175 | neutral amino acid transmembrane transporter activity |
IDA | 12930836 | | GO:0015179 | L-amino acid transmembrane transporter activity |
IEA | -- | About this table | Pathways & Interactions for SLC43A1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for SLC43A1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for SLC43A1
|
Transcripts for SLC43A1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003627
Sigma-Aldrich siRNA and siRNA Panels for SLC43A1  Sigma-Aldrich shRNA for SLC43A1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003627 REFSEQ mRNAs for SLC43A1 gene: NM_003627.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003627               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003627                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003627                                  untagged cDNA clone in CMV expression vector: NM_003627  Additional cDNA sequence: AB103033.1 AF045584.1 AK027732.1 BC001639.2 CR606379.1 12 DOTS entries: DT.415269 DT.102827623 DT.75120558 DT.40123707 DT.95364920 DT.92429257 DT.40109130 DT.75153345 DT.92414849 DT.95088669 DT.95100065 DT.95346861 24/114 AceView cDNA sequences (see all 114
):AI567334 BM451394 BQ029981 BQ049835 CO250090 BG397532 CR606379 AI859012 AK027732 BQ227946 AA345572 BX494561 BU182024 AB103033 BQ678583 BC001639 AA447955 BE396312 BF801187 AA040486 BX956133 NM_003627 BE293435 BI906713
highest scoring ESTs for SLC43A1:AB103033 AF045584 BX956133 CO250090 AA040589 AA136451 AA177117 AA251114 AA255667 AA345572 Unigene Cluster for SLC43A1: Solute carrier family 43, member 1 Hs.591952 [show with all ESTs]Unigene Representative Sequence: NM_003627
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SLC43A1 (see all 12
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | |
| SP1: | |   | |   | - |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |
| SP5: | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 21a | · | 21b | · | 21c | ^ | 22 | |
| SP1: | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for SLC43A1
1 Ensembl transcript including schematic representation: ENST00000278426
|
Expression for SLC43A1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| SLC43A1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for SLC43A1
1 / 2 / 3 3 probe-sets matching SLC43A1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGTCTGTGTA
SOURCE GeneReport for Unigene cluster: Hs.591952
Expression variation in blood from EXPOLDB for SLC43A1 UniProtKB/Swiss-Prot: LAT3_HUMAN, O75387Tissue specificity: In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells |
Orthologs for SLC43A1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SLC43A1 gene from 5 species
About this table Species with no ortholog for SLC43A1
ENSEMBL Gene Tree for SLC43A1 | Paralogs for SLC43A1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for SLC43A1 gene
- SLC43A32 SLC43A22
|
SNPs/Variants for SLC43A1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for SLC43A1 (up to first 250kb)
|
Disorders & Mutations for SLC43A1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603733
3 Novoseek disease relationships for SLC43A1 gene
About this table
|
Medical News for SLC43A1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for SLC43A1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for SLC43A1 gene (see all 12
):- cDNA sequencing and analysis of POV1 (PB39): a novel gene up-regulated in prostate cancer. (PubMed id 9722952)1, 2, 3, 4 Cole K.A....Emmert-Buck M.R. (1998)
- Identification of a novel transcript up-regulated in a clinically aggressive prostate carcinoma. (PubMed id 9255310)2, 3, 4 Chuaqui R.F....Emmert-Buck M.R. (1997)
- Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. (PubMed id 12930836)1, 3, 4 Babu E.... Endou H. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- New insights into testicular germ cell tumorigenesis from gene expression profiling. (PubMed id 11956097)3, 4 Skotheim R.I.... Kallioniemi A. (2002)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Encephalomalacia unrelated to vascular occlusion. (PubMed id 972295)3 Shuangshoti S. and Viratchai C. (1976)
- Identification of two molecular groups of seminomas by using expression and tissue microarrays. (PubMed id 16115909)1 Hofer M.D....Rubin M.A. (2005)
- EEG1, a putative transporter expressed during epithelial organogenesis: comparison with embryonic transporter expression during nephrogenesis. (PubMed id 11704567)1 Stuart R.O....Nigam S.K. (2001)
|
Search for SLC43A1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SLC43A1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing SLC43A1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC43A1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for SLC43A1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for SLC43A1:

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Incremental update: 13 Oct 2009
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