POU6F2 Gene
protein-coding GIFtS : 53
GCID: GC07 P039012
POU class 6 homeobox 2 (Previous names: POU domain, class 6, transcription factor 2 )
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Aliasesfor POU6F2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases POU Class 6 Homeobox 2 1 2 WTSL2 5 RPF-11 2 3 Retina-Derived POU-Domain Factor-12 POU Domain, Class 6, Transcription Factor 21 2 Wilms Tumor Suppressor Locus2 Retina-Derived POU Domain Factor 12 3 RPF13 WT52 5
Export aliases for POU6F2 gene to outside databases Previous GC identifers: GC07P038787 GC07P038819
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Summariesfor POU6F2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for POU6F2 : This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.(provided by RefSeq, Oct 2009) UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424 Function : Probable transcription factor likely to be involved in early steps in the differentiation of amacrine andganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Viewsfor POU6F2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the POU6F2 gene promoter: STAT5B ISGF-3 HOXA3 AML1a Nkx2-2 FOXD1 C/EBPalpha Gfi-1 FAC1 FOXO4 Other transcription factors Search SABiosciences Chromatin IP Primers for POU6F2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU6F2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7p14.1 Ensembl cytogenetic band: 7p14.1 HGNC cytogenetic band: 7p14.1 POU6F2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07P039012: view genomic region
(about GC identifiers )
Start:
39,017,598 bp from pter
End:
39,532,694 bp from pter
Size:
515,097 bases
Orientation:
plus strand
1 alternative location : Chr 7+,CRA_TCAG 39,055,332-39,542,296
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Proteinsfor POU6F2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424 (See
protein sequence )Recommended Name: POU domain, class 6, transcription factor 2 Size : 691 amino acids; 73265 Da
Subcellular location : Nucleus (Probable)
Sequence caution : Sequence=AAB49727.1; Type=Erroneous gene model prediction; Sequence=AAB49728.1; Type=Erroneousinitiation; Note=Translation N-terminally extended; Sequence=AAS07475.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAL23992.1; Type=Erroneous gene model prediction;
Secondary accessions : A4D1W2 C4AMB9 P78425 Q75ME8 Q86UM6 Q9UDS7Alternative splicing : 2 isoforms : P78424-1 P78424-2 (Major isoform)Explore the universe of human proteins at neXtProt for POU6F2: NX_P78424 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P78424 POU6F2 Protein expression data from MOPED and PaxDb : --REFSEQ proteins (2 alternative transcripts):
NP_001159490.1 NP_009183.3 ENSEMBL proteins: ENSP00000384004 ENSP00000430514 ENSP00000409684 ENSP00000452911 ENSP00000453020 ENSP00000452621 ENSP00000452633 ENSP00000404868 Human Recombinant Protein Products for POU6F2: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IDA --
POU6F2 for ontologies About GeneDecksing POU6F2 Antibody Products: Assay Products for POU6F2:
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Protein
Domains / Familiesfor POU6F2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
POU6F2 for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P78424 ProtoNet protein and cluster: P78424
2 Blocks protein families : IPB000327 POU domain IPB013847 POU UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424 Similarity : Belongs to the POU transcription factor family. Class-6 subfamilySimilarity : Contains 1 homeobox DNA-binding domainSimilarity : Contains 1 POU-specific domain
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Functionfor POU6F2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: PO6F2_HUMAN, P78424 Function : Probable transcription factor likely to be involved in early steps in the differentiation of amacrine andganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003700 sequence-specific DNA binding transcription factor activity
TAS 8601806 GO:0043565 sequence-specific DNA binding
IEA --
POU6F2 for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for POU6F2 : 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Pou6f2) :
POU6F2 for phenotypes About GeneDecksing Animal Models: Mouse knock-out Pou6f2 tm1Nat for POU6F2Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for POU6F2 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for POU6F2 (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): POU6F2 (NM_007252 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POU6F2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat POU6F2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU6F2
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Pathways & Interactionsfor POU6F2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POU6F2 1 Interacting protein for POU6F2 (P78424 3 ) via UniProtKB, MINT, STRING, and/or I2D About this table Gene Ontology (GO): 5 biological process terms (GO ID links to tree view) : About this table
POU6F2 for ontologies About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Drugs & Compoundsfor POU6F2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for POU6F2 Search CenterWatch for drugs/clinical trials and news about POU6F2 / PO6F2
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Transcriptsfor POU6F2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for POU6F2 gene (2 alternative transcripts): NM_001166018.1 NM_007252.3 Unigene Cluster for POU6F2:
POU class 6 homeobox 2 Hs.137106 [show with all ESTs ] Unigene Representative Sequence: NM_007252 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000403058 (uc003thb.2 uc022acb.1 ) ENST00000518318 ENST00000517348 (uc010kxo.3 )ENST00000451021 ENST00000524147 ENST00000520104 ENST00000558333 ENST00000559001 ENST00000464276 ENST00000416452 ENST00000558712 ENST00000426456 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for POU6F2 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for POU6F2 (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): POU6F2 (NM_007252 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POU6F2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat POU6F2
Additional cDNA sequence: U91935.1
4 DOTS entries : DT.97812925 DT.91693741
DT.402711 DT.91714277 18 AceView cDNA sequences :
BM724167 NM_007252 BU741744 BM680332 BX108040 AI928867 BM724588 U91935 BX646845 AW261867 AI252764 AI929032 AI025567 BF931113 AI761853 H08886 BF357653 BF831355 GeneLoc Exon Structure
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Expression for POU6F2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section POU6F2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TCTCAAAGTCAbout this image POU6F2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
Genevestigator expression for POU6F2 SOURCE GeneReport for Unigene cluster: Hs.137106 UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424 Tissue specificity : Expressed only within the CNS, where its expression is restricted to the medical habenulla, to adispersed population of neurons in the dorsal hypothalamus, and to subsets of ganglion and amacrine cells in the retina SABiosciences Custom PCR Arrays for POU6F2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for POU6F2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat POU6F2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat POU6F2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat POU6F2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU6F2
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Orthologsfor POU6F2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for POU6F2 gene from 4/15 species (see all 15 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
POU6F21
POU class 6 homeobox 2
85.08(n) 91.32(a)
 
420763 XM_418861.3 XP_418861.2
lizard (Anolis carolinensis)
Reptilia
POU6F26
--
60(a)
1 ↔ 1
6(48684466-48703152)
zebrafish (Danio rerio)
Actinopterygii
si:ch211-124o16.36
si:ch211-124o16.3
60(a)
1 ↔ 1
24(9855503-10076387)
fruit fly (Drosophila melanogaster)
Insecta
pdm31
pou domain motif 3
48.63(n) 40.48(a)
 
35813 NM_001144145.3 NP_001137617.2
ENSEMBL Gene Tree for POU6F2 (if available)TreeFam Gene Tree for POU6F2 (if available)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Paralogsfor POU6F2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for POU6F2 gene POU5F2 2 POU4F2 2 POU2F3 2 POU3F4 2 POU3F1 2 POU1F1 2 POU4F3 2 POU3F3 2 POU3F2 2 POU2F2 2 POU5F1B 2 POU2F1 2 POU4F1 2 POU5F1 2 POU6F1 2 4 SIMAP similar genes for POU6F2 using alignment to 7 protein entries: PO6F2_HUMAN (see all proteins ):POU6F1 OCT6 OCT-2 POU1F1
POU6F2 for paralogs About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Variantsfor POU6F2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 7 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More