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POU6F2 Gene

protein-coding   GIFtS: 52
GCID: GC07P039012

POU Class 6 Homeobox 2

(Previous names: POU domain, class 6, transcription factor 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
POU Class 6 Homeobox 21 2     WT52 5
POU Domain, Class 6, Transcription Factor 21 2     WTSL2 5
Retina-Derived POU-Domain Factor-11 2     Wilms Tumor Suppressor Locus2
Retina-Derived POU Domain Factor 12 3     RPF13
RPF-12 3     

External Ids:    HGNC: 216941   Entrez Gene: 112812   Ensembl: ENSG000001065367   OMIM: 6090625   UniProtKB: P784243   

Export aliases for POU6F2 gene to outside databases

Previous GC identifers: GC07P038787 GC07P038819


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POU6F2 Gene:
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding
domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA
binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The
POU family members are transcriptional regulators, many of which are known to control cell type-specific
differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition.
Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.(provided by
RefSeq, Oct 2009)

GeneCards Summary for POU6F2 Gene:
POU6F2 (POU class 6 homeobox 2) is a protein-coding gene. Diseases associated with POU6F2 include wilms tumor susceptibility-5, and wilms tumor, type 1. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424
Function: Probable transcription factor likely to be involved in early steps in the differentiation of amacrine
and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the POU6F2 gene promoter:
         STAT5B   ISGF-3   HOXA3   AML1a   Nkx2-2   FOXD1   C/EBPalpha   Gfi-1   FAC1   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see first 1): POU6F2 promoter sequences (S716262  S720529  S720542)
   Search Chromatin IP Primers for POU6F2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU6F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.1   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p14.1

POU6F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU6F2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P039012:  view genomic region     (about GC identifiers)

Start:
39,017,598 bp from pter      End:
39,532,694 bp from pter
Size:
515,097 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 39,055,332-39,542,296     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424 (See protein sequence)
Recommended Name: POU domain, class 6, transcription factor 2  
Size: 691 amino acids; 73265 Da
Sequence caution: Sequence=AAB49727.1; Type=Erroneous gene model prediction; Sequence=AAB49728.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAS07475.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=EAL23992.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D1W2 C4AMB9 P78425 Q75ME8 Q86UM6 Q9UDS7
Alternative splicing: 2 isoforms:  P78424-1   P78424-2   (Major isoform)

Explore the universe of human proteins at neXtProt for POU6F2: NX_P78424

Explore proteomics data for POU6F2 at MOPED


See POU6F2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001159490.1  NP_009183.3  

ENSEMBL proteins: 
 ENSP00000384004   ENSP00000430514   ENSP00000409684   ENSP00000452911   ENSP00000453020  
 ENSP00000452633   ENSP00000475747   ENSP00000404868  

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Cloud-Clone Corp. CLIAs for POU6F2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
POU: Homeoboxes / POU class

Selected InterPro protein domains (see all 6):
 IPR010982 Lambda_DNA-bd_dom
 IPR013847 POU
 IPR000327 POU_specific
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P78424

ProtoNet protein and cluster: P78424

2 Blocks protein domains:
IPB000327 POU domain
IPB013847 POU


UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424
Similarity: Belongs to the POU transcription factor family. Class-6 subfamily
Similarity: Contains 1 homeobox DNA-binding domain
Similarity: Contains 1 POU-specific domain


POU6F2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: PO6F2_HUMAN, P78424
Function: Probable transcription factor likely to be involved in early steps in the differentiation of amacrine
and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity TAS8601806
GO:0043565sequence-specific DNA binding IEA--
     
POU6F2 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for POU6F2:
 Increased gamma-H2AX phosphory 

     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pou6f2):
 normal 

POU6F2 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Pou6f2tm1Nat for POU6F2

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POU6F2
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU6F2

miRNA
Products:
    
miRTarBase miRNAs that target POU6F2:
hsa-mir-335-5p (MIRT016800)

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU6F2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
PO6F2_HUMAN, P78424: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IC8601806

POU6F2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POU6F2
Interactions:

    Search GeneGlobe Interaction Network for POU6F2

1 Interacting protein for POU6F2 (P784243) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
POU6F1Q148633I2D: score=1 
About this table

Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006355regulation of transcription, DNA-templated TAS8601806
GO:0006366transcription from RNA polymerase II promoter TAS8601806
GO:0007402ganglion mother cell fate determination TAS8601806
GO:0007417central nervous system development TAS8601806
GO:0007601visual perception TAS8601806

POU6F2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for POU6F2 (PO6F2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for POU6F2 gene (2 alternative transcripts): 
NM_001166018.1  NM_007252.3  

Unigene Cluster for POU6F2:

POU class 6 homeobox 2
Hs.137106  [show with all ESTs]
Unigene Representative Sequence: NM_007252
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000403058(uc003thb.2 uc022acb.1) ENST00000518318 ENST00000517348(uc010kxo.3)
ENST00000451021 ENST00000524147 ENST00000520104 ENST00000559001 ENST00000464276
ENST00000416452 ENST00000426456
miRNA
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Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POU6F2
  QuantiTect SYBR Green Assays in human, mouse, rat POU6F2
  QuantiFast Probe-based Assays in human, mouse, rat POU6F2

Additional mRNA sequence: U91935.1 

4 DOTS entries:

DT.97812925  DT.91693741  DT.402711  DT.91714277 

18 AceView cDNA sequences:

BU741744 BM680332 NM_007252 BM724167 AI928867 BX108040 AW261867 BX646845 
U91935 BM724588 AI252764 AI025567 AI929032 BF931113 AI761853 H08886 
BF357653 BF831355 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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POU6F2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCTCAAAGTC
POU6F2 Expression
About this image


POU6F2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Neural Tube (Nervous System)    fully expand to see all 2 entries
         Spinal Ventral Columns
 
 Eye (Sensory Organs)
         Retina
 
 Brain (Nervous System)
         Medulla Oblongata
 
 Larynx (Respiratory System)
POU6F2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

POU6F2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.137106

UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424
Tissue specificity: Expressed only within the CNS, where its expression is restricted to the medical habenulla, to
a dispersed population of neurons in the dorsal hypothalamus, and to subsets of ganglion and amacrine cells in
the retina

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU6F2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for POU6F2 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Pou6f25 POU domain, class 6, transcription factor 2   --   13 (6.05 cM) 18121101 
chicken
(Gallus gallus)
Aves POU6F26
POU class 6 homeobox 2
85(a)
1 ↔ 1
2(50031906-50327049)
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
80(a)
77(a)
1 ↔ many
1 ↔ many
6(48235250-48478489)
6(48684466-48703152)
zebrafish
(Danio rerio)
Actinopterygii pou6f26
POU class 6 homeobox 2
70(a)
1 ↔ 1
24(9839895-10076387) ENSDARG00000086362
fruit fly
(Drosophila melanogaster)
Insecta pdm36
pou domain motif 3
18(a)
1 ↔ 1
2R(4215005-4283785)


ENSEMBL Gene Tree for POU6F2 (if available)
TreeFam Gene Tree for POU6F2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for POU6F2 gene
POU5F22  POU4F22  POU2F32  POU3F12  POU3F42  POU1F12  POU3F32  POU4F32  
POU3F22  POU2F22  POU5F1B2  POU4F12  POU2F12  POU6F12  POU5F12  
4 SIMAP similar genes for POU6F2 using alignment to 7 protein entries:     PO6F2_HUMAN (see all proteins):
POU6F1    OCT6    OCT-2    POU1F1

POU6F2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for POU6F2 (see all 9327)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0224194
Hereditary susceptibility to Wilms tumor 5 (WT5)4--see VAR_0224192 Q H mis40--------
rs8595401,2
C,F,O--38990913(-) GGATGG/ACGTGA 2 -- us2k19Minor allele frequency- A:0.20NA WA 388
rs8595391,2
C,F,H--38990946(-) CGTCCT/ACGGAC 2 -- us2k110Minor allele frequency- A:0.13MN NS EA NA WA 840
rs1136449551,2
C--38991222(+) TTCGGA/GCAAGT 2 -- us2k10--------
rs168799821,2
C,F,H--38991440(+) TGCACG/CGTCTC 2 -- us2k18Minor allele frequency- C:0.05NA NS EA WA 680
rs284064221,2
C--38991489(+) TGTGTC/GTGTGT 2 -- us2k10--------
rs2000759881,2
C--38991503(+) TGTGTG/TTGTGT 2 -- us2k10--------
rs2011635431,2
C--38991512(+) GTGTGC/TGTGCG 2 -- us2k10--------
rs624436011,2
--38991514(+) GTGTGC/TGCGCG 2 -- us2k11Minor allele frequency- T:0.50NA 2
rs674133211,2
C--38991519(+) GTGTG-/GCGC  
        
CGCGC
2 -- us2k10--------

HapMap Linkage Disequilibrium report for POU6F2 (39017598 - 39267598 bp, first 250kb of POU6F2)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for POU6F2 (see all 21):    About this table    
Variant IDTypeSubtypePubMed ID
esv2734299CNV Deletion23290073
esv2670994CNV Deletion23128226
esv2734293CNV Deletion23290073
esv2734297CNV Deletion23290073
esv2734296CNV Deletion23290073
esv2734294CNV Deletion23290073
esv2236589CNV Deletion18987734
esv1002601CNV Deletion20482838
esv2670460CNV Deletion23128226
esv1455501CNV Deletion17803354

Human Gene Mutation Database (HGMD): POU6F2
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing POU6F2
DNA2.0 Custom Variant and Variant Library Synthesis for POU6F2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609062   
OMIM disorders: 601583  
UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424
  • Hereditary susceptibility to Wilms tumor 5 (WT5) [MIM:601583]: Pediatric malignancy of kidney and one of
    the most common solid cancers in childhood. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 10 diseases for POU6F2:    
    About MalaCards
    wilms tumor susceptibility-5    wilms tumor, type 1    wilms tumor 2    wilms tumor
    nephroblastoma    retinitis    multiple myeloma    myeloma
    endotheliitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for POU6F2:
    Nephroblastoma

    POU6F2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): POU6F2
    Human Genome Epidemiology (HuGE) Navigator: POU6F2 (3 documents)

    Export disorders for POU6F2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POU6F2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with POU6F2)
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    1. Retina-derived POU-domain factor-1: a complex POU-domain gene implicated in the development of retinal ganglion and amacrine cells. (PubMed id 8601806)1, 2, 3, 9 Zhou H.... Nathans J. (J. Neurosci. 1996)
    2. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. A genome-wide scan for common alleles affecting risk for autism. (PubMed id 20663923)1, 4 Anney R....Hallmayer J. (Hum. Mol. Genet. 2010)
    5. Germline mutations of the POU6F2 gene in Wilms tumors with loss of heterozygosity on chromosome 7p14. (PubMed id 15459955)1, 4 Perotti D....Radice P. (Hum. Mutat. 2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    7. Refinement within single yeast artificial chromosome clones of a minimal region commonly deleted on the short arm of chromosome 7 in Wilms tumours. (PubMed id 11284034)1, 2 Perotti D.... Radice P. (Genes Chromosomes Cancer 2001)
    8. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11281 HGNC: 21694 AceView: POU6F2 Ensembl:ENSG00000106536 euGenes: HUgn11281
    ECgene: POU6F2 H-InvDB: POU6F2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POU6F2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POU6F2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    Patent Information for POU6F2 gene:
    Search GeneIP for patents involving POU6F2

    GeneCards and IP:
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