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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU6F2 Gene

protein-coding   GIFtS: 53
GCID: GC07P039012

POU Class 6 Homeobox 2

(Previous names: POU domain, class 6, transcription factor 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
POU Class 6 Homeobox 21 2     WT52 5
POU Domain, Class 6, Transcription Factor 21 2     WTSL2 5
Retina-Derived POU-Domain Factor-11 2     Wilms Tumor Suppressor Locus2
Retina-Derived POU Domain Factor 12 3     RPF13
RPF-12 3     

External Ids:    HGNC: 216941   Entrez Gene: 112812   Ensembl: ENSG000001065367   OMIM: 6090625   UniProtKB: P784243   

Export aliases for POU6F2 gene to outside databases

Previous GC identifers: GC07P038787 GC07P038819


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POU6F2 Gene:
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding
domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA
binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The
POU family members are transcriptional regulators, many of which are known to control cell type-specific
differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition.
Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.(provided by
RefSeq, Oct 2009)

GeneCards Summary for POU6F2 Gene: 
POU6F2 (POU class 6 homeobox 2) is a protein-coding gene. Diseases associated with POU6F2 include wilms tumor susceptibility-5, and wilms tumor 2. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424
Function: Probable transcription factor likely to be involved in early steps in the differentiation of amacrine
and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU6F2 gene promoter:
         STAT5B   ISGF-3   HOXA3   AML1a   Nkx2-2   FOXD1   C/EBPalpha   Gfi-1   FAC1   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): POU6F2 promoter sequence
   Search SABiosciences Chromatin IP Primers for POU6F2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU6F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.1   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p14.1

POU6F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU6F2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P039012:  view genomic region     (about GC identifiers)

Start:
39,017,598 bp from pter      End:
39,532,694 bp from pter
Size:
515,097 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 39,055,332-39,542,296     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424 (See protein sequence)
Recommended Name: POU domain, class 6, transcription factor 2  
Size: 691 amino acids; 73265 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAB49727.1; Type=Erroneous gene model prediction; Sequence=AAB49728.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAS07475.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=EAL23992.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D1W2 C4AMB9 P78425 Q75ME8 Q86UM6 Q9UDS7
Alternative splicing: 2 isoforms:  P78424-1   P78424-2   (Major isoform)

Explore the universe of human proteins at neXtProt for POU6F2: NX_P78424

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78424

  • POU6F2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (2 alternative transcripts): 
    NP_001159490.1  NP_009183.3  

    ENSEMBL proteins: 
     ENSP00000384004   ENSP00000430514   ENSP00000409684   ENSP00000452911   ENSP00000453020  
     ENSP00000452633   ENSP00000475747   ENSP00000404868  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for POU6F2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    POU6F2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    POU: Homeoboxes / POU class

    5 InterPro protein domains:
     IPR010982 Lambda_DNA-bd_dom
     IPR013847 POU
     IPR000327 POU_specific
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P78424

    ProtoNet protein and cluster: P78424

    2 Blocks protein domains:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424
    Similarity: Belongs to the POU transcription factor family. Class-6 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    POU6F2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO6F2_HUMAN, P78424
    Function: Probable transcription factor likely to be involved in early steps in the differentiation of amacrine
    and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8601806
    GO:0043565sequence-specific DNA binding IEA--
         
    POU6F2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for POU6F2:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pou6f2):
     normal 

    POU6F2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pou6f2tm1Nat for POU6F2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for POU6F2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU6F2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU6F2 

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POU6F2

    1 Interacting protein for POU6F2 (P784243) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POU6F1Q148633I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent TAS8601806
    GO:0006366transcription from RNA polymerase II promoter TAS8601806
    GO:0007402ganglion mother cell fate determination TAS8601806
    GO:0007417central nervous system development TAS8601806
    GO:0007601visual perception TAS8601806

    POU6F2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POU6F2 (PO6F2)

    Search CenterWatch for drugs/clinical trials and news about POU6F2 / PO6F2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POU6F2 gene (2 alternative transcripts): 
    NM_001166018.1  NM_007252.3  

    Unigene Cluster for POU6F2:

    POU class 6 homeobox 2
    Hs.137106  [show with all ESTs]
    Unigene Representative Sequence: NM_007252
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403058(uc003thb.2 uc022acb.1) ENST00000518318 ENST00000517348(uc010kxo.3)
    ENST00000451021 ENST00000524147 ENST00000520104 ENST00000559001 ENST00000464276
    ENST00000416452 ENST00000426456
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU6F2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU6F2

    Additional mRNA sequence: U91935.1 

    4 DOTS entries:

    DT.97812925  DT.91693741  DT.402711  DT.91714277 

    18 AceView cDNA sequences:

    BM724167 BU741744 BM680332 NM_007252 AI928867 BX108040 AW261867 BM724588 
    U91935 AI252764 BX646845 AI929032 AI025567 BF931113 AI761853 H08886 
    BF357653 BF831355 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU6F2 expression in normal human tissues (normalized intensities)      POU6F2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCAAAGTC
    POU6F2 Expression
    About this image


    POU6F2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Spinal Ventral Columns
             brain/midbrain/lateral wall   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             brain/midbrain/lateral wall   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             Human corneal endothelial cells
     
     Endothelium (Cardiovascular System)
             Human corneal endothelial cells
     
     Larynx (Respiratory System)

    Genevestigator expression for POU6F2

    SOURCE GeneReport for Unigene cluster: Hs.137106

    UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424
    Tissue specificity: Expressed only within the CNS, where its expression is restricted to the medical habenulla, to
    a dispersed population of neurons in the dorsal hypothalamus, and to subsets of ganglion and amacrine cells in
    the retina

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU6F2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for POU6F2 gene from 10 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia POU6F21 POU class 6 homeobox 2 99.11(n)
    99.24(a)
      472351  XM_527726.2  XP_527726.2 
    mouse
    (Mus musculus)
    Mammalia Pou6f21 , 5 POU domain, class 6, transcription factor 21, 5 91.58(n)1
    95.42(a)1
      13 (6.05 cM)5
    2180301  NM_175006.21  NP_778171.21 
     181211015 
    cow
    (Bos taurus)
    Mammalia POU6F21 POU class 6 homeobox 2 83.57(n)
    84.42(a)
      517861  NM_001102046.1  NP_001095516.1 
    dog
    (Canis familiaris)
    Mammalia POU6F21 POU class 6 homeobox 2 92.24(n)
    94.37(a)
      483249  XM_540368.4  XP_540368.4 
    oppossum
    (Monodelphis domestica)
    Mammalia POU6F26
    POU class 6 homeobox 2
    80(a)
    1 ↔ 1
    6(284557640-284956642)
    platypus
    (Ornithorhynchus anatinus)
    Mammalia POU6F26
    POU class 6 homeobox 2
    79(a)
    1 ↔ 1
    Ultra117(727282-749195)
    chicken
    (Gallus gallus)
    Aves POU6F21 POU class 6 homeobox 2 85.08(n)
    91.32(a)
      420763  XM_418861.3  XP_418861.2 
    lizard
    (Anolis carolinensis)
    Reptilia POU6F26
    Uncharacterized protein
    78(a)
    1 ↔ 1
    6(48684466-48703152)
    zebrafish
    (Danio rerio)
    Actinopterygii POU6F26
    POU class 6 homeobox 2
    71(a)
    1 ↔ 1
    24(9855503-10076387)
    fruit fly
    (Drosophila melanogaster)
    Insecta pdm31 pou domain motif 3 48.63(n)
    40.48(a)
      35813  NM_001144145.3  NP_001137617.2 
            Species with no ortholog for POU6F2

    ENSEMBL Gene Tree for POU6F2 (if available)
    TreeFam Gene Tree for POU6F2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POU6F2 gene
    POU5F22  POU4F22  POU2F32  POU3F12  POU3F42  POU1F12  POU3F32  POU4F32  
    POU3F22  POU2F22  POU5F1B2  POU4F12  POU2F12  POU6F12  POU5F12  
    4 SIMAP similar genes for POU6F2 using alignment to 6 protein entries:     PO6F2_HUMAN (see all proteins):
    POU6F1    OCT6    OCT-2    POU1F1

    POU6F2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9327 SNPs in POU6F2 are shown (see all 9327)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0224194
    Hereditary susceptibility to Wilms tumor 5 (WT5)4--see VAR_0224192 Q H mis40--------
    rs8595401,2
    C,F,O--38990913(-) GGATGG/ACGTGA 2 -- us2k19Minor allele frequency- A:0.20NA WA 388
    rs8595391,2
    C,F,H--38990946(-) CGTCCT/ACGGAC 2 -- us2k110Minor allele frequency- A:0.13MN NS EA NA WA 840
    rs1136449551,2
    C--38991222(+) TTCGGA/GCAAGT 2 -- us2k10--------
    rs168799821,2
    C,F,H--38991440(+) TGCACG/CGTCTC 2 -- us2k18Minor allele frequency- C:0.05NA NS EA WA 680
    rs284064221,2
    C--38991489(+) TGTGTC/GTGTGT 2 -- us2k10--------
    rs2000759881,2
    C--38991503(+) TGTGTG/TTGTGT 2 -- us2k10--------
    rs2011635431,2
    C--38991512(+) GTGTGC/TGTGCG 2 -- us2k10--------
    rs624436011,2
    --38991514(+) GTGTGC/TGCGCG 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs674133211,2
    C--38991519(+) GTGTG-/GCGC  
            
    CGCGC
    2 -- us2k10--------

    HapMap Linkage Disequilibrium report for POU6F2 (39017598 - 39267598 bp, first 250kb of POU6F2)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for POU6F2 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734299CNV Deletion23290073
    esv2670994CNV Deletion23128226
    esv2734293CNV Deletion23290073
    esv2734297CNV Deletion23290073
    esv2734296CNV Deletion23290073
    esv2734294CNV Deletion23290073
    esv2236589CNV Deletion18987734
    esv1002601CNV Deletion20482838
    esv2670460CNV Deletion23128226
    esv1455501CNV Deletion17803354


    Human Gene Mutation Database (HGMD): POU6F2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609062   
    OMIM disorders: 601583  
    UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424
  • Hereditary susceptibility to Wilms tumor 5 (WT5) [MIM:601583]: Pediatric malignancy of kidney and one of
    the most common solid cancers in childhood. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 6 diseases for POU6F2:    About MalaCards
    wilms tumor susceptibility-5    wilms tumor 2    wilms tumor    nephroblastoma
    retinitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for POU6F2:
    Nephroblastoma

    POU6F2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): POU6F2
    Human Genome Epidemiology (HuGE) Navigator: POU6F2 (3 documents)

    Export disorders for POU6F2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU6F2 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with POU6F2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Retina-derived POU-domain factor-1: a complex POU-domain gene implicated in the development of retinal ganglion and amacrine cells. (PubMed id 8601806)1, 2, 3, 9 Zhou H.... Nathans J. (1996)
    2. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. A genome-wide scan for common alleles affecting risk for autism. (PubMed id 20663923)1, 4 Anney R....Hallmayer J. (2010)
    5. Germline mutations of the POU6F2 gene in Wilms tumors with loss of heterozygosity on chromosome 7p14. (PubMed id 15459955)1, 4 Perotti D....Radice P. (2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    7. Refinement within single yeast artificial chromosome clones of a minimal region commonly deleted on the short arm of chromosome 7 in Wilms tumours. (PubMed id 11284034)1, 2 Perotti D.... Radice P. (2001)
    8. Loci associated with N-glycosylation of human immunogl obulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (2013)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11281 HGNC: 21694 AceView: POU6F2 Ensembl:ENSG00000106536 euGenes: HUgn11281
    ECgene: POU6F2 H-InvDB: POU6F2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POU6F2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POU6F2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for POU6F2 gene:
    Search GeneIP for patents involving POU6F2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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