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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU6F2 Gene

protein-coding   GIFtS: 53
GCID: GC07P039012

POU class 6 homeobox 2

(Previous names: POU domain, class 6, transcription factor 2 )
 Explore 6 diseases affiliated with
POU6F2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for POU6F2    

Aliases
for POU6F2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
POU Class 6 Homeobox 21 2     WTSL2 5
RPF-11 2 3     Retina-Derived POU-Domain Factor-12
POU Domain, Class 6, Transcription Factor 21 2     Wilms Tumor Suppressor Locus2
Retina-Derived POU Domain Factor 12 3     RPF13
WT52 5     

External Ids:    HGNC: 216941   Entrez Gene: 112812   Ensembl: ENSG000001065367   OMIM: 6090625   UniProtKB: P784243   

Export aliases for POU6F2 gene to outside databases

Previous GC identifers: GC07P038787 GC07P038819


Summaries
for POU6F2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for POU6F2:
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain,
consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may
bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are
transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene
is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding
distinct isoforms have been found for this gene.(provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424
Function: Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and
ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA




Genomic Views
for POU6F2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU6F2 gene promoter:
         STAT5B   ISGF-3   HOXA3   AML1a   Nkx2-2   FOXD1   C/EBPalpha   Gfi-1   FAC1   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): POU6F2 promoter sequence
   Search SABiosciences Chromatin IP Primers for POU6F2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU6F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.1   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p14.1

POU6F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU6F2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P039012:  view genomic region     (about GC identifiers)

Start:
 39,017,598 bp from pter      End:
 39,532,694 bp from pter
Size:
 515,097 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 39,055,332-39,542,296     

Proteins
for POU6F2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424 (See protein sequence)
Recommended Name: POU domain, class 6, transcription factor 2  
Size: 691 amino acids; 73265 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAB49727.1; Type=Erroneous gene model prediction; Sequence=AAB49728.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAS07475.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=EAL23992.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D1W2 C4AMB9 P78425 Q75ME8 Q86UM6 Q9UDS7
Alternative splicing: 2 isoforms:  P78424-1   P78424-2   (Major isoform)

Explore the universe of human proteins at neXtProt for POU6F2: NX_P78424

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P78424

    • POU6F2 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins (2 alternative transcripts): 
    NP_001159490.1  NP_009183.3  

    ENSEMBL proteins: 
     ENSP00000384004   ENSP00000430514   ENSP00000409684   ENSP00000452911   ENSP00000453020  
     ENSP00000452621   ENSP00000452633   ENSP00000404868  

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    Uscn Proteins for POU6F2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--


    POU6F2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for POU6F2

    Protein Domains /
    Families
    for POU6F2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    POU6F2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR010982 Lambda_DNA-bd_dom
     IPR013847 POU
     IPR000327 POU_specific
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P78424

    ProtoNet protein and cluster: P78424

    2 Blocks protein families:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424
    Similarity: Belongs to the POU transcription factor family. Class-6 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    Function
    for POU6F2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424
    Function: Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and
    ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: POU6F2
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for POU6F2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU6F2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8601806
    GO:0043565sequence-specific DNA binding IEA--


    POU6F2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for POU6F2:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Pou6f2tm1Nat for POU6F2
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Pou6f2):
     normal 

    POU6F2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for POU6F2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POU6F2

    1 Interacting protein for POU6F2 (P784243) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POU6F1Q148633I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent TAS8601806
    GO:0006366transcription from RNA polymerase II promoter TAS8601806
    GO:0007402ganglion mother cell fate determination TAS8601806
    GO:0007417central nervous system development TAS8601806
    GO:0007601visual perception TAS8601806


    POU6F2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for POU6F2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POU6F2
    Search CenterWatch for drugs/clinical trials and news about POU6F2 / PO6F2 

    Transcripts
    for POU6F2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for POU6F2 gene (2 alternative transcripts): 
    NM_001166018.1  NM_007252.3  

    Unigene Cluster for POU6F2:

    POU class 6 homeobox 2
    Hs.137106  [show with all ESTs]
    Unigene Representative Sequence: NM_007252
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403058(uc003thb.2 uc022acb.1) ENST00000518318 ENST00000517348(uc010kxo.3)
    ENST00000451021 ENST00000524147 ENST00000520104 ENST00000558333 ENST00000559001
    ENST00000464276 ENST00000416452 ENST00000558712 ENST00000426456

    miRNA
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    Inhib. RNA
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    NM_001166018 (human cat#: TG310265)  BC094915 (mouse cat#: TF517171)  BC094915 (mouse cat#: TG517171)  
    BC094915 (mouse cat#: TR517171)  NM_001101002 (rat cat#: TG704257)  
    OriGene shRNA RFP: POU6F2
    OriGene siRNA: POU6F2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU6F2
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU6F2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU6F2

    Additional cDNA sequence: U91935.1 

    4 DOTS entries:

    DT.97812925  DT.91693741  DT.402711  DT.91714277 

    18 AceView cDNA sequences:

    BM724167 NM_007252 BU741744 BM680332 BX108040 AI928867 BM724588 U91935 
    BX646845 AW261867 AI252764 AI929032 AI025567 BF931113 AI761853 H08886 
    BF357653 BF831355 

    GeneLoc Exon Structure


    Expression
    for POU6F2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU6F2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTCAAAGTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    POU6F2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainMedulla OblongataBrain
    EyeRetinaEye
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    Genevestigator expression for POU6F2

    SOURCE GeneReport for Unigene cluster: Hs.137106

    UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424
    Tissue specificity: Expressed only within the CNS, where its expression is restricted to the medical habenulla, to a
    dispersed population of neurons in the dorsal hypothalamus, and to subsets of ganglion and amacrine cells in the
    retina

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    In Situ
    Assay Products:     
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    Orthologs
    for POU6F2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for POU6F2 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves POU6F21 POU class 6 homeobox 2 85.08(n)
    91.32(a)    		   420763  XM_418861.3  XP_418861.2 
    lizard
    (Anolis carolinensis)    		 Reptilia POU6F26
    		 --
    		 60(a)
    		 1 ↔ 1
    		 6(48684466-48703152)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-124o16.36
    		 si:ch211-124o16.3
    		 60(a)
    		 1 ↔ 1
    		 24(9855503-10076387)
    fruit fly
    (Drosophila melanogaster)    		 Insecta pdm31 pou domain motif 3 48.63(n)
    40.48(a)    		   35813  NM_001144145.3  NP_001137617.2 


    ENSEMBL Gene Tree for POU6F2 (if available)
    TreeFam Gene Tree for POU6F2 (if available) 

    Paralogs
    for POU6F2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POU6F2 gene
    POU5F22  POU4F22  POU2F32  POU3F42  POU3F12  POU1F12  POU4F32  POU3F32  
    POU3F22  POU2F22  POU5F1B2  POU2F12  POU4F12  POU5F12  POU6F12  
    4 SIMAP similar genes for POU6F2 using alignment to 7 protein entries:     PO6F2_HUMAN (see all proteins):
    POU6F1    OCT6    OCT-2    POU1F1

    POU6F2 for paralogs           About GeneDecksing



    Genomic Variants
    for POU6F2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7902 NCBI SNPs in POU6F2 are shown (see all 7902)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs624436011,2
    		--39016223(+) GTGTGC/TGCGCG 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1471985151,2
    		C,--39016223(+) TGTGT-/GCGC  
                GCGCG     		2 -- us2k10--------
    rs583762131,2
    		C--39016233(+) CGCGCGCGC/-  
                TTCGG     		2 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1395790481,2
    		C,--39016305(+) TTCTTA/CCTTGA 2 -- us2k10--------
    rs736954921,2
    		C,--39016598(+) CCAAGT/ATAACG 2 -- us2k13Minor allele frequency- A:0.17WA EA 240
    rs1817138861,2
    		--39016603(+) TTAACC/GGATGG 2 -- us2k10--------
    rs1841449671,2
    		--39016697(+) AGAAGG/TTTAAA 2 -- us2k10--------
    rs171715011,2
    		C,F,--39016711(+) TTGGTA/GAGTTA 2 -- us2k16Minor allele frequency- G:0.04NA WA EA 500
    rs1442893071,2
    		--39016789(+) ATCAGA/GTAGTT 2 -- us2k10--------
    rs1888731751,2
    		--39016981(+) CTATGA/TCCACT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for POU6F2 (39017598 - 39267598 bp, first 250kb of POU6F2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for POU6F2: --
    Human Gene Mutation Database (HGMD): POU6F2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POU6F2
    DNA2.0 Custom Variant and Variant Library Synthesis for POU6F2

    Disorders / Diseases
    for POU6F2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    POU6F2 for disorders           About GeneDecksing

    OMIM gene information: 609062   
    OMIM disorders: 601583  
    UniProtKB/Swiss-Prot: PO6F2_HUMAN, P78424
  • Defects in POU6F2 are a cause of hereditary susceptibility to Wilms tumor 5 (WT5) [MIM:601583]. WT5 is a
    • pediatric malignancy of kidney and one of the most common solid cancers in childhood

    6 diseases for POU6F2:    About MalaCards
    wilms tumor    wilms tumor susceptibility-5    nephroblastoma    twinning
    retinitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for POU6F2:
    Nephroblastoma
    Genetic Association Database (GAD): POU6F2
    Human Genome Epidemiology (HuGE) Navigator: POU6F2 (3 documents)

    Export disorders for POU6F2 gene to outside databases

    Publications
    for POU6F2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU6F2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with POU6F2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Retina-derived POU-domain factor-1: a complex POU-domain gene implicated in the development of retinal ganglion and amacrine cells. (PubMed id 8601806)1, 2, 3, 9 Zhou H.... Nathans J. (1996)
    2. Germline mutations of the POU6F2 gene in Wilms tumors with loss of heterozygosity on chromosome 7p14. (PubMed id 15459955)1, 4 Perotti D....Radice P. (2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Refinement within single yeast artificial chromosome clones of a minimal region commonly deleted on the short arm of chromosome 7 in Wilms tumours. (PubMed id 11284034)1, 2 Perotti D.... Radice P. (2001)
    5. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1 Joslyn G....White R.L. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. A genome-wide scan for common alleles affecting risk for autism. (PubMed id 20663923)1 Anney R....Hallmayer J. (2010)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    9. The murine Pou6f2 gene is temporally and spatially re gulated during kidney embryogenesis and its human homolog is overexpressed in a subset of Wilms tumors. (PubMed id 17164647)1 Di Renzo F....Perotti D. (2006)
    10. Wilms tumor in monozygous twins: clinical, pathologic al, cytogenetic and molecular case report. (PubMed id 16217254)1 Perotti D....Radice P. (2005)

    External Searches for POU6F2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing POU6F2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11281 HGNC: 21694 AceView: POU6F2 Ensembl:ENSG00000106536 euGenes: HUgn11281
    ECgene: POU6F2 H-InvDB: POU6F2

    Other Databases showing POU6F2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing POU6F2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POU6F2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POU6F2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for POU6F2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for POU6F2 gene:
    Search GeneIP for patents involving POU6F2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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