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Aliasesfor POU6F1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section This gene clusters with an RNA geneSubcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases POU Class 6 Homeobox 1 1 2 MPOU Homeobox Protein2 3 BRN51 2 3 Brain-53 MPOU1 2 3 Brn-53 TCFB11 2 3 Brain-53 POU Domain, Class 6, Transcription Factor 11 2 Brn-53 Brain-Specific Homeobox/POU Domain Protein 52 3
External Ids: HGNC: 9224 1 Entrez Gene: 5463 2 Ensembl: ENSG00000184271 7 UniProtKB: Q14863 3 ORGUL members: NONCODE:n407436
Export aliases for POU6F1 gene to outside databases Previous GC identifers: GC12U990075 GC12M051299 GC12M049869 GC12M048613
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Summariesfor POU6F1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: PO6F1_HUMAN, Q14863 Function : Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3') (Bysimilarity)
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Genomic Viewsfor POU6F1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_029419.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the POU6F1 gene promoter: E2F-4 E2F-3a E2F-5 Nkx2-5 E2F-2 CREB E2F E2F-1 deltaCREB c-Myb Other transcription factors Search SABiosciences Chromatin IP Primers for POU6F1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat POU6F1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13 POU6F1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M051580: view genomic region
(about GC identifiers )
Start:
51,580,719 bp from pter
End:
51,611,477 bp from pter
Size:
30,759 bases
Orientation:
minus strand
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Proteinsfor POU6F1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PO6F1_HUMAN, Q14863 (See
protein sequence )Recommended Name: POU domain, class 6, transcription factor 1 Size : 301 amino acids; 32645 Da
Subcellular location : Nucleus
1 PDB 3D structure from and Proteopedia for POU6F1 :3D1N (3D)
 
Secondary accessions : Q15944 Q6DK47 Q7Z7P6Explore the universe of human proteins at neXtProt for POU6F1: NX_Q14863 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q14863 POU6F1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_002693.3 ENSEMBL proteins: ENSP00000373895 ENSP00000330190 ENSP00000448389 ENSP00000448266 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
-- -- GO:0031965 nuclear membrane
IDA -- GO:0043231 intracellular membrane-bounded organelle
IDA --
POU6F1 for ontologies About GeneDecksing POU6F1 Antibody Products: Assay Products for POU6F1:
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Protein
Domains / Familiesfor POU6F1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
POU6F1 for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q14863 ProtoNet protein and cluster: Q14863
2 Blocks protein families : IPB000327 POU domain IPB013847 POU UniProtKB/Swiss-Prot: PO6F1_HUMAN, Q14863 Similarity : Belongs to the POU transcription factor family. Class-6 subfamilySimilarity : Contains 1 homeobox DNA-binding domainSimilarity : Contains 1 POU-specific domain
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Functionfor POU6F1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: PO6F1_HUMAN, Q14863 Function : Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3') (Bysimilarity)
Genatlas biochemistry entry for POU6F1 : POU domain,class 6,transcription factor 1,mammalian homeo box backfoot,Drosophila bicoid related,expressed in Rathke pouch,at an early stage of pituitary development and in a subset of adult anterior pituitary cells that express POMC Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for POU6F1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for POU6F1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: POU6F1 (NM_002702 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POU6F1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat POU6F1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU6F1
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding
-- -- GO:0003700 sequence-specific DNA binding transcription factor activity
IEA -- GO:0043565 sequence-specific DNA binding
IEA --
POU6F1 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for POU6F1 :
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Pathways & Interactionsfor POU6F1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Transcription factors in neurogenesis
Pathway sources See GeneCards unified pathways Show all pathways 1 EMD Millipore Pathway for POU6F1
POU6F1 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POU6F1 4 Interacting proteins for POU6F1 (Q14863 3 ) via UniProtKB, MINT, STRING, and/or I2D About this table Gene Ontology (GO): 5 biological process terms (GO ID links to tree view) : About this table
POU6F1 for ontologies About GeneDecksing
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Drugs & Compoundsfor POU6F1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for POU6F1 Search CenterWatch for drugs/clinical trials and news about POU6F1 / PO6F1
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Transcriptsfor POU6F1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for POU6F1 gene: NM_002702.3 Unigene Cluster for POU6F1:
POU class 6 homeobox 1 Hs.555886 [show with all ESTs ] Unigene Representative Sequence: NR_026893 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000389243 (uc001rxy.3 uc001rxz.3 uc001rya.3 ) ENST00000333640 ENST00000550824 ENST00000552305 ENST00000547855 ENST00000549309 ENST00000546685 ENST00000548692 ENST00000547854 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for POU6F1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for POU6F1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: POU6F1 (NM_002702 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POU6F1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat POU6F1
Additional cDNA sequence: AL832881.1 BC051326.1 BC074765.2 BC107090.1 L14482.1 NR_026893.1 Z21966.1
11 DOTS entries : DT.211139 DT.100019233
DT.92416809 DT.100719359 DT.121124774 DT.411233 DT.86852017 DT.100804567 DT.65284314 DT.95231668 DT.40200606 24/36 AceView cDNA sequences (see all 36 ):
AF268617 BV207801 BV207798 BV199669 CA503120 AU123692 AA205845 BG569724 Z21964 CD048028 CD247950 CD048171 BQ278003 BV174940 AA216545 AA196616 AA232432 CD247215 BM830060 BM857157 AW438879 CD049202 AA176079 AA216743 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for POU6F1 (see all 6 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b SP1 :             -       -                 SP2 :                   -                 SP3 :                                   SP4 :   -           -                       SP5 :       -                            
ECgene alternative splicing isoforms for POU6F1
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Expression for POU6F1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section POU6F1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTGGAAGGAA
About this image POU6F1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See POU6F1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for POU6F1 SOURCE GeneReport for Unigene cluster: Hs.555886 UniProtKB/Swiss-Prot: PO6F1_HUMAN, Q14863 Tissue specificity : In the embryo, expressed exclusively in the developing brain, whereas in the adult its expressionis restricted to brain, heart, skeletal muscle and lung. In the brain, the highest expression levels are found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum SABiosciences Custom PCR Arrays for POU6F1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for POU6F1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat POU6F1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat POU6F1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat POU6F1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU6F1
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Orthologsfor POU6F1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for POU6F1 gene from 3/12 species (see all 12 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
lizard (Anolis carolinensis)
Reptilia
POU6F16
--
37(a)
1 ↔ 1
2(67513364-67531505)
tropical clawed frog (Xenopus tropicalis)
Amphibia
Str.130062
Transcribed sequence with strong similarity to protein more
80(n)
 
BX724095.1
zebrafish (Danio rerio)
Actinopterygii
pouc2
POU domain gene C
73.53(n)
 
30334 NM_131113.1
ENSEMBL Gene Tree for POU6F1 (if available)TreeFam Gene Tree for POU6F1 (if available)
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Paralogsfor POU6F1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for POU6F1 gene POU5F2 2 POU6F2 2 POU4F2 2 POU2F3 2 POU3F4 2 POU3F1 2 POU1F1 2 POU4F3 2 POU3F3 2 POU3F2 2 POU2F2 2 POU5F1B 2 POU2F1 2 POU4F1 2 POU5F1 2 18/82 SIMAP similar genes for POU6F1 using alignment to 3 protein entries: PO6F1_HUMAN (see all proteins )
(see all similar genes ):POU6F2 POU4F3 POU3F2 OCT6 POU3F1 OCT-2 POU2F3 POU3F3 POU4F2 POU1F1 POU4F1 POU5F1B POU5F1P4 POU2F1 POU3F4 LHX9 EN2 GSC
POU6F1 for paralogs About GeneDecksing
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Genomic Variantsfor POU6F1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More