Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



POU6F1 Gene

protein-coding   GIFtS: 56
GCID: GC12M051580

POU Class 6 Homeobox 1

(Previous names: POU domain, class 6, transcription factor 1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
POU Class 6 Homeobox 11 2     MPOU Homeobox Protein2 3
POU Domain, Class 6, Transcription Factor 11 2     brain-52
Brain-Specific Homeobox/POU Domain Protein 52 3     brn-52
BRN52 3     Brain-53
MPOU2 3     Brn-53
TCFB12 3     

External Ids:    HGNC: 92241   Entrez Gene: 54632   Ensembl: ENSG000001842717   UniProtKB: Q148633   

Export aliases for POU6F1 gene to outside databases

Previous GC identifers: GC12U990075 GC12M051299 GC12M049869 GC12M048613


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for POU6F1 Gene:
POU6F1 (POU class 6 homeobox 1) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO6F1_HUMAN, Q14863
Function: Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3') (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the POU6F1 gene promoter:
         E2F-4   E2F-3a   E2F-5   Nkx2-5   E2F-2   CREB   E2F   E2F-1   deltaCREB   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): POU6F1 promoter sequence
   Search Chromatin IP Primers for POU6F1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU6F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

POU6F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU6F1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M051580:  view genomic region     (about GC identifiers)

Start:
51,580,719 bp from pter      End:
51,611,477 bp from pter
Size:
30,759 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PO6F1_HUMAN, Q14863 (See protein sequence)
Recommended Name: POU domain, class 6, transcription factor 1  
Size: 301 amino acids; 32645 Da
1 PDB 3D structure from and Proteopedia for POU6F1:
3D1N (3D)    
Secondary accessions: Q15944 Q6DK47 Q7Z7P6

Explore the universe of human proteins at neXtProt for POU6F1: NX_Q14863

Explore proteomics data for POU6F1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POU6F1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002693.3  
    ENSEMBL proteins: 
     ENSP00000373895   ENSP00000330190   ENSP00000448389   ENSP00000448266  

    POU6F1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for POU6F1
    OriGene Protein Over-expression Lysate for POU6F1
    OriGene MassSpec for POU6F1
    OriGene Custom Protein Services for POU6F1
    GenScript Custom Purified and Recombinant Proteins Services for POU6F1
    Novus Biologicals POU6F1 Proteins
    Novus Biologicals POU6F1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for POU6F1
    Cloud-Clone Corp. Proteins for POU6F1

     
    Search eBioscience for Proteins for POU6F1 

     
    antibodies-online proteins for POU6F1 (5 products) 

     
    antibodies-online peptides for POU6F1

    POU6F1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of POU6F1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for POU6F1
    Novus Biologicals POU6F1 Antibodies
    Abcam antibodies for POU6F1
    Cloud-Clone Corp. Antibodies for POU6F1
    ThermoFisher Antibodies for POU6F1
    antibodies-online antibodies for POU6F1 (42 products) 

    POU6F1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for POU6F1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POU6F1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for POU6F1
    Cloud-Clone Corp. CLIAs for POU6F1
    Search eBioscience for ELISAs for POU6F1 
    antibodies-online kits for POU6F1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    POU: Homeoboxes / POU class

    5 InterPro protein domains:
     IPR010982 Lambda_DNA-bd_dom
     IPR013847 POU
     IPR000327 POU_specific
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q14863

    ProtoNet protein and cluster: Q14863

    2 Blocks protein domains:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO6F1_HUMAN, Q14863
    Similarity: Belongs to the POU transcription factor family. Class-6 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    Find genes that share domains with POU6F1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO6F1_HUMAN, Q14863
    Function: Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3') (By
    similarity)

         Genatlas biochemistry entry for POU6F1:
    POU domain,class 6,transcription factor 1,mammalian homeo box backfoot,Drosophila bicoid related,expressed in
    Rathke pouch,at an early stage of pituitary development and in a subset of adult anterior pituitary cells that
    express POMC

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with POU6F1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for POU6F1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for POU6F1

    miRNA
    Products:
        
    miRTarBase miRNAs that target POU6F1:
    hsa-mir-335-5p (MIRT018056)

    Block miRNA regulation of human, mouse, rat POU6F1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate POU6F1 (see all 63):
    hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-106a hsa-miR-218-1* hsa-miR-301a hsa-miR-766 hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidPOU6F1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for POU6F1
    Predesigned siRNA for gene silencing in human, mouse, rat POU6F1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for POU6F1

    Clone
    Products:
         
    OriGene clones in human, mouse for POU6F1 (see all 7)
    OriGene ORF clones in mouse, rat for POU6F1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POU6F1 (NM_002702)
    Sino Biological Human cDNA Clone for POU6F1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU6F1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU6F1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for POU6F1
    Browse ESI BIO Cell Lines and PureStem Progenitors for POU6F1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU6F1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PO6F1_HUMAN, Q14863: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0031965nuclear membrane ----
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with POU6F1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for POU6F1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcription factors in neurogenesis
    Transcription factors in neurogenesis




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POU6F1
    Interactions:

        Search GeneGlobe Interaction Network for POU6F1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for POU6F1 (Q148633 ENSP000003301904) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POU4F2Q128373, ENSP000002813214I2D: score=1 STRING: ENSP00000281321
    STAT3P407633, ENSP000002646574I2D: score=1 STRING: ENSP00000264657
    HOXD12P354523I2D: score=1 
    POU6F2P784243I2D: score=1 
    STAT2ENSP000003157684STRING: ENSP00000315768
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007420brain development TAS7908264
    GO:0007507heart development TAS7908264
    GO:0007517muscle organ development TAS7908264

    Find genes that share ontologies with POU6F1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POU6F1 (PO6F1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for POU6F1 gene: 
    NM_002702.3  

    Unigene Cluster for POU6F1:

    POU class 6 homeobox 1
    Hs.555886  [show with all ESTs]
    Unigene Representative Sequence: NR_026893
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389243(uc001rxy.3 uc001rxz.3 uc001rya.3) ENST00000333640
    ENST00000550824 ENST00000552305 ENST00000547855 ENST00000549309 ENST00000546685
    ENST00000548692 ENST00000547854
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat POU6F1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate POU6F1 (see all 63):
    hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-106a hsa-miR-218-1* hsa-miR-301a hsa-miR-766 hsa-miR-764
    SwitchGear 3'UTR luciferase reporter plasmidPOU6F1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for POU6F1
    Predesigned siRNA for gene silencing in human, mouse, rat POU6F1
    Clone
    Products:
         
    OriGene clones in human, mouse for POU6F1 (see all 7)
    OriGene ORF clones in mouse, rat for POU6F1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POU6F1 (NM_002702)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU6F1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU6F1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for POU6F1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POU6F1
      QuantiTect SYBR Green Assays in human, mouse, rat POU6F1
      QuantiFast Probe-based Assays in human, mouse, rat POU6F1

    Additional mRNA sequence: 

    AL832881.1 BC051326.1 BC074765.2 BC107090.1 L14482.1 NR_026893.1 Z21966.1 

    11 DOTS entries:

    DT.211139  DT.100019233  DT.92416809  DT.100719359  DT.121124774  DT.411233  DT.86852017  DT.100804567 
    DT.65284314  DT.95231668  DT.40200606 

    Selected AceView cDNA sequences (see all 36):

    AF268617 AA205845 CA503120 BV199669 BG569724 BV207798 Z21964 BV207801 
    AU123692 AA196616 BM857157 BQ278003 AA176079 CD048028 CD048171 BV174940 
    AW438879 AA232432 CD247215 CD049202 BM830060 CD247950 AA216545 CD248298 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for POU6F1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
    SP1:                                      -                 -                                             
    SP2:                                                        -                                             
    SP3:                                                                                                      
    SP4:        -                             -                                                               
    SP5:                    -                                                                                 


    ECgene alternative splicing isoforms for POU6F1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    POU6F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGAAGGAA
    POU6F1 Expression
    About this image


    POU6F1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             ganglion/cranial/facial VII   
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
     
     Spinal Cord (Nervous System)
    POU6F1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POU6F1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.555886

    UniProtKB/Swiss-Prot: PO6F1_HUMAN, Q14863
    Tissue specificity: In the embryo, expressed exclusively in the developing brain, whereas in the adult its
    expression is restricted to brain, heart, skeletal muscle and lung. In the brain, the highest expression levels
    are found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum

        Custom PCR Arrays for POU6F1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for POU6F1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POU6F1
    QuantiTect SYBR Green Assays in human, mouse, rat POU6F1
    QuantiFast Probe-based Assays in human, mouse, rat POU6F1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU6F1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for POU6F1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou6f11 , 5 POU domain, class 6, transcription factor 11, 5 87.82(n)1
    95.35(a)1
      15 (56.35 cM)5
    190091  NM_010127.31  NP_034257.11 
     1005753185 
    lizard
    (Anolis carolinensis)
    Reptilia POU6F16
    POU class 6 homeobox 1
    47(a)
    1 ↔ 1
    2(67512138-67531505)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.130062 Transcribed sequence with strong similarity to protein more 80(n)    BX724095.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pouc2 POU domain gene C 73.53(n)   30334  NM_131113.1 


    ENSEMBL Gene Tree for POU6F1 (if available)
    TreeFam Gene Tree for POU6F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for POU6F1 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F12  POU3F42  POU1F12  POU3F32  
    POU4F32  POU3F22  POU2F22  POU5F1B2  POU4F12  POU2F12  POU5F12  
    Selected SIMAP similar genes for POU6F1 using alignment to 3 protein entries:     PO6F1_HUMAN     F8VSI9_HUMAN     Q3B832_HUMAN(see all similar genes)(see first protein):
    POU6F2    POU4F3    POU2F3    POU3F2    OCT6    POU3F1
    OCT-2    POU3F3    POU4F2    POU1F1    POU4F1    POU2F1
    POU5F1B    POU5F1P4    POU3F4    LHX9    EN2    GSC

    Find genes that share paralogs with POU6F1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for POU6F1 (see all 608)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922152461,2
    --48626932(+) TGTAAA/GGACTG 1 -- us2k10--------
    rs107834181,2
    C,F,A,H--51580219(+) GCTCTT/CATCAG 2 -- ds500123Minor allele frequency- C:0.46NS EA NA WA CSA 2342
    rs1430268841,2
    C--51580225(+) ATCAGA/GCATCG 2 -- ds50010--------
    rs1913415261,2
    --51580308(+) AGGCAC/TTGAGT 2 -- ds50010--------
    rs1165358301,2
    C,F--51580459(+) CTAGGT/CATAAG 2 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1826330141,2
    --51580468(+) AGAAGC/GGTGTT 2 -- ds50010--------
    rs1481952601,2
    --51580618(+) TTTTCC/TAGGCT 2 -- ds50010--------
    rs111697521,2
    C,F,A,H--51580707(+) GGAAAC/AAAGCA 2 -- ds500119Minor allele frequency- A:0.15NS EA NA CSA WA 2344
    rs1411889981,2
    C--51580732(+) AAAAAA/TTACTG 2 -- ut31 nc-transcript-variant0--------
    rs769283551,2
    C,F--51580947(+) AACTCG/ATGTGT 2 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.05WA 118

    HapMap Linkage Disequilibrium report for POU6F1 (51580719 - 51611477 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for POU6F1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677962CNV Deletion23128226
    esv2745877CNV Deletion23290073
    esv2745881CNV Deletion23290073
    esv2239902CNV Deletion18987734
    esv2745878CNV Deletion23290073
    esv2745880CNV Deletion23290073
    esv2745879CNV Deletion23290073
    esv2745882CNV Deletion23290073
    nsv704CNV Insertion18451855
    esv1696566CNV Insertion17803354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POU6F1
    DNA2.0 Custom Variant and Variant Library Synthesis for POU6F1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    1 disease from the University of Copenhagen DISEASES database for POU6F1:
    Clear cell adenocarcinoma

    Find genes that share disorders with POU6F1           About GenesLikeMe


    Export disorders for POU6F1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for POU6F1 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with POU6F1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. (PubMed id 7908264)1, 2, 3, 9 Wey E.... Schaefer B.W. (Eur. J. Biochem. 1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. A novel POU domain protein which binds to the T-cell receptor beta enhancer. (PubMed id 8102789)1, 2 Messier H.... Fotedar A. (Mol. Cell. Biol. 1993)
    4. Structure of human Brn-5 transcription factor in complex with CRH gene promoter. (PubMed id 19450691)1, 9 Pereira J.H. and Kim S.H. (J. Struct. Biol. 2009)
    5. Crystallization and preliminary X-ray analysis of human Brn-5 transcription factor in complex with DNA. (PubMed id 18323601)1, 9 Pereira J.H....Kim S.H. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2008)
    6. Transcription factor POU6F1 is important for proliferation of clear cell adenocarcinoma of the ovary and is a potential new molecular target. (PubMed id 20134265)1 Suzuki N....Ishizuka B. (Int. J. Gynecol. Cancer 2010)
    7. POU6F1 is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary. (PubMed id 19874398)1 Yoshioka N....Ishizuka B. (Hum. Cell 2009)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5463 HGNC: 9224 AceView: LOC441628 Ensembl:ENSG00000184271 euGenes: HUgn5463
    ECgene: POU6F1 H-InvDB: POU6F1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for POU6F1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for POU6F1 gene:
    Search GeneIP for patents involving POU6F1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of POU6F1
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for POU6F1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for POU6F1  
     OriGene MassSpec for POU6F1   OriGene clones in human, mouse for POU6F1  
     OriGene qSTAR qPCR primer pairs in human, mouse for POU6F1   OriGene Purified Protein for POU6F1  
     OriGene ORF clones in mouse, rat for POU6F1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for POU6F1   OriGene Custom Protein Services for POU6F1  

     
     
     Block miRNA regulation of human, mouse, rat POU6F1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing POU6F1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU6F1 Predesigned siRNA for gene silencing in human, mouse, rat POU6F1
     QuantiFast Probe-based Assays in human, mouse, rat POU6F1 QuantiTect SYBR Green Assays in human, mouse, rat POU6F1
     Custom PCR Arrays for POU6F1 Search Chromatin IP Primers for POU6F1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POU6F1  Search GeneGlobe Interaction Network for POU6F1
     Regulatory tfbs in POU6F1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for POU6F1 GenScript cDNA clones with any tag delivered in your preferred vector for POU6F1
     GenScript Custom Assay Services for POU6F1 GenScript Custom overexpressing Cell Line Services for POU6F1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for POU6F1 (PO6F1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for POU6F1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     POU6F1 antibodies
     POU6F1 proteins
     POU6F1 lysates
     Antibodies for POU6F1
     See all of Abcam's Antibodies, Kits and Proteins for POU6F1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for POU6F1
     Proteins for POU6F1
     Antibodies for POU6F1
     ELISAs for POU6F1
     CLIAs for POU6F1



     Browse ESI BIO Cell Lines and PureStem Progenitors for POU6F1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU6F1
     SwitchGear 3'UTR luciferase reporter plasmids for POU6F1
     SwitchGear Promoter luciferase reporter plasmids for POU6F1
     ThermoFisher Antibodies for POU6F1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU6F1
     Browse compounds at ApexBio
     Search Addgene for plasmids for POU6F1
      Search eBioscience for proteins for POU6F1
      Search eBioscience for elisas for POU6F1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for POU6F1
     antibodies-online antibodies for POU6F1 (42 products)
     antibodies-online kits for POU6F1 (6 products)
     antibodies-online peptides for POU6F1
     antibodies-online proteins for POU6F1 (5 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      POU6F1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4