Aliases for POU6F1 Gene
Aliases for POU6F1 Gene
External Ids for POU6F1 Gene
- HGNC: 9224
- Entrez Gene: 5463
- Ensembl: ENSG00000184271
- UniProtKB: Q14863
Previous GeneCards Identifiers for POU6F1 Gene
- GC12U990075
- GC12M051299
- GC12M049869
- GC12M051580
- GC12M048613
Summaries for POU6F1 Gene
GeneCards Summary for POU6F1 Gene
POU6F1 (POU Class 6 Homeobox 1) is a Protein Coding gene. Diseases associated with POU6F1 include Clear Cell Adenocarcinoma Of The Ovary. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is POU6F2.
UniProtKB/Swiss-Prot for POU6F1 Gene
-
Transcription factor that binds preferentially to a variant of the octamer motif (5-ATGATAAT-3).
Additional gene information for POU6F1 Gene
- Monarch Initiative
- Search for POU6F1 at DataMed
- Search for POU6F1 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU6F1 Gene
Genomics for POU6F1 Gene
GeneHancer (GH) Regulatory Elements for POU6F1 Gene
Regulatory Element Products
Genomic Locations for POU6F1 Gene
- chr12:51,186,936-51,217,708
- (GRCh38/hg38)
- Size:
- 30,773 bases
- Orientation:
- Minus strand
- chr12:51,580,719-51,611,477
- (GRCh37/hg19)
Genomic View for POU6F1 Gene
- Cytogenetic band:
-
- 12q13.13 by Ensembl
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC


RefSeq DNA sequence for POU6F1 Gene
Proteins for POU6F1 Gene
-
Protein details for POU6F1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14863-PO6F1_HUMAN
- Recommended name:
- POU domain, class 6, transcription factor 1
- Protein Accession:
- Q14863
- Q15944
- Q6DK47
- Q7Z7P6
Protein attributes for POU6F1 Gene
- Size:
- 301 amino acids
- Molecular mass:
- 32645 Da
- Quaternary structure:
- No Data Available
Protein Expression for POU6F1 Gene
Post-translational modifications for POU6F1 Gene
Other Protein References for POU6F1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001317351.1
- NP_001338017.1
- NP_002693.3
- XP_016874996.1
- XP_016874997.1
- XP_016874998.1
- XP_016874999.1
- XP_016875000.1
- XP_016875001.1
- XP_016875002.1
- XP_016875003.1
- XP_016875004.1
- XP_016875005.1
- XP_016875006.1
- XP_016875007.1
- XP_016875008.1
- XP_016875009.1
- XP_016875010.1
- XP_016875011.1
- XP_016875012.1
- XP_016875013.1
- XP_016875014.1
- XP_016875015.1
- XP_016875016.1
- XP_016875017.1
- XP_016875018.1
- XP_016875019.1
Antibody Products
-
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-
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-
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Protein Products
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Assay Products
No data available for DME Specific Peptides for POU6F1 Gene
Domains & Families for POU6F1 Gene
Gene Families for POU6F1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for POU6F1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for POU6F1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14863UniProtKB/Swiss-Prot:
PO6F1_HUMAN :- Belongs to the POU transcription factor family. Class-6 subfamily.
- Family:
-
- Belongs to the POU transcription factor family. Class-6 subfamily.
Function for POU6F1 Gene
Molecular function for POU6F1 Gene
- GENATLAS Biochemistry:
- POU domain,class 6,transcription factor 1,mammalian homeo box backfoot,Drosophila bicoid related,expressed in Rathke pouch,at an early stage of pituitary development and in a subset of adult anterior pituitary cells that express POMC
- UniProtKB/Swiss-Prot Function:
- Transcription factor that binds preferentially to a variant of the octamer motif (5-ATGATAAT-3).
Phenotypes From GWAS Catalog for POU6F1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA | -- |
GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IDA | 8645295 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA binding transcription factor activity | TAS | 7908264 |
GO:0043565 | sequence-specific DNA binding | IDA | 8645295 |
Phenotypes for POU6F1 Gene
- GenomeRNAi human phenotypes for POU6F1:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression
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miRNA for POU6F1 Gene
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POU6F1 Gene
Localization for POU6F1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for POU6F1 Gene
- Nucleus.
- Nuclear bodies (3)
- Actin filaments (1)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0015629 | actin cytoskeleton | IDA | -- |
GO:0016604 | nuclear body | IDA | -- |
Pathways & Interactions for POU6F1 Gene
Interacting Proteins for POU6F1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 8645295 |
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0007420 | brain development | TAS | 7908264 |
GO:0007507 | heart development | TAS | 7908264 |
No data available for Pathways by source and SIGNOR curated interactions for POU6F1 Gene
Transcripts for POU6F1 Gene
mRNA/cDNA for POU6F1 Gene
- (27) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (51) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for POU6F1 Gene
CRISPR Products
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OriGene CRISPR knockouts for POU6F1
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-
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available POU6F1 gene related products
- orf clones - Search results for available POU6F1 gene related products
- Applied Biological Materials Clones for POU6F1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||
SP6: | - | - |
Expression for POU6F1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Spinal Cord (Nervous System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POU6F1 Gene
NURSA nuclear receptor signaling pathways regulating expression of POU6F1 Gene:
POU6F1SOURCE GeneReport for Unigene cluster for POU6F1 Gene:
Hs.555886mRNA Expression by UniProt/SwissProt for POU6F1 Gene:
Q14863-PO6F1_HUMANEvidence on tissue expression from TISSUES for POU6F1 Gene
- Nervous system(4.7)
- Muscle(4.1)
Primer Products
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No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for POU6F1 Gene
Orthologs for POU6F1 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | POU6F1 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | POU6F1 34 |
|
OneToMany | |
Pou6f1 33 16 34 |
|
||||
cow (Bos Taurus) |
Mammalia | POU6F1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | POU6F1 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Pou6f1 33 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | POU6F1 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | POU6F1 34 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | POU6F1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | pou6f1 33 |
|
||
Str.13006 33 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | pou6f1 33 34 |
|
||
pouc 33 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | CG11641 35 |
|
|
- Species where no ortholog for POU6F1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for POU6F1 Gene
Paralogs for POU6F1 Gene
(77) SIMAP similar genes for POU6F1 Gene using alignment to 3 proteins:
- POU6F2
- POU4F3
- POU2F3
- POU3F2
- POU3F1
- OCT6
- OCT-2
- POU4F2
- POU3F3
- POU1F1
- POU4F1
- POU5F1B
- POU2F1
- POU5F1P4
- POU3F4
- LHX9
- POU5F2
- LHX5
- LHX1
- GSC
- EN2
- POU2F2
- POU5F1P1
- POU5F1
- ZFHX3
- PRRX2
- LHX8
- EN1
- ARGFX
- ZFHX2
- HESX1
- DPRX
- TPRX2P
- TPRX1
- OTX1
- MEOX2
- MEOX1
- LHX6
- VAX2
- VAX1
- PRRX1
- PROP1
- ESX1
- EMX2
- DLX5
- NANOGP8
- NANOGP1
- NANOG
- HOXB4
- CRX
- PITX3
- PITX2
- NKX6-3
- HOXD4
- HOXD12
- DUX5
- DUX4L9
- DUX4L7
- DUX4L6
- DUX4L5
- DUX4L4
- DUX4L3
- DUX4L2
- DUX4
- DLX3
- DLX2
- OTX2
- EMX1
- DUXA
- ZFHX4
- RAX
- PITX1
- HOXC4
- HOXA4
- DMBX1
- PBX2
- PAX4
Variants for POU6F1 Gene
SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000053695 | -- | 51,197,716(-) | T/C | intron_variant | |
rs1000090226 | -- | 51,193,709(-) | G/C | intron_variant | |
rs1000306046 | -- | 51,201,444(-) | A/C | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000384606 | -- | 51,188,761(-) | C/T | 3_prime_UTR_variant, non_coding_transcript_variant | |
rs1000425479 | -- | 51,216,796(-) | T/A | genic_upstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1696566 | CNV | insertion | 17803354 |
esv2239902 | CNV | deletion | 18987734 |
esv2677962 | CNV | deletion | 23128226 |
esv2745877 | CNV | deletion | 23290073 |
esv2745878 | CNV | deletion | 23290073 |
esv2745879 | CNV | deletion | 23290073 |
esv2745880 | CNV | deletion | 23290073 |
esv2745881 | CNV | deletion | 23290073 |
esv2745882 | CNV | deletion | 23290073 |
esv34039 | CNV | loss | 18971310 |
esv3892200 | CNV | loss | 25118596 |
nsv1069666 | CNV | deletion | 25765185 |
nsv1121850 | CNV | deletion | 24896259 |
nsv1122733 | CNV | deletion | 24896259 |
nsv558876 | CNV | gain | 21841781 |
nsv704 | CNV | insertion | 18451855 |
Additional Variant Information for POU6F1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- POU6F1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU6F1 Gene
Disorders for POU6F1 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
clear cell adenocarcinoma of the ovary |
|
|
Additional Disease Information for POU6F1
No data available for UniProtKB/Swiss-Prot and Genatlas for POU6F1 Gene
Publications for POU6F1 Gene
- A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. (PMID: 7908264) Wey E … Schäfer BW (European journal of biochemistry 1994) 2 3 4 22 58
- Structure of human Brn-5 transcription factor in complex with CRH gene promoter. (PMID: 19450691) Pereira JH … Kim SH (Journal of structural biology 2009) 3 22 58
- Crystallization and preliminary X-ray analysis of human Brn-5 transcription factor in complex with DNA. (PMID: 18323601) Pereira JH … Kim SH (Acta crystallographica. Section F, Structural biology and crystallization communications 2008) 3 22 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Identification of novel DNA binding sites recognized by the transcription factor mPOU (POU6F1). (PMID: 8645295) Wey E … Schäfer BW (Biochemical and biophysical research communications 1996) 3 22 58
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- ViGene Biosciences adenoviral particle packaged cDNA for POU6F1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for POU6F1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for POU6F1 gene
- Search ViGene Biosciences for POU6F1
- Santa Cruz Biotechnology (SCBT) Antibodies for POU6F1
- Search Santa Cruz Biotechnology (SCBT) for POU6F1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for POU6F1
- Horizon Cell Lines for POU6F1
- genomics-online: cdna clones - Search results for available POU6F1 gene related products
- orf clones - Search results for available POU6F1 gene related products
- genomics-online: gRNA clones - Search results for available POU6F1 gene related products
- genomics-online: primer clones - Search results for available POU6F1 gene related products
- genomics-online: shRNA clones - Search results for available POU6F1 gene related products
Sources for POU6F1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew