POU6F1 Gene
protein-coding GIFtS : 54 GCID: GC12 M051580
POU class 6 homeobox 1 POU domain, class 6, transcription factor 1 )
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Aliasesfor POU6F1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Subcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases POU Class 6 Homeobox 1 1 2 MPOU Homeobox Protein2 3 BRN51 2 3 Brain-53 MPOU1 2 3 Brn-53 TCFB11 2 3 Brain-53 POU Domain, Class 6, Transcription Factor 11 2 Brn-53 Brain-Specific Homeobox/POU Domain Protein 52 3
External Ids: HGNC: 9224 1 Entrez Gene: 5463 2 Ensembl: ENSG00000184271 7 UniProtKB: Q14863 3 ORGUL members: NONCODE:n407436
Export aliases for POU6F1 gene to outside databases Previous GC identifers: GC12U990075 GC12M051299 GC12M049869 GC12M048613
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Summariesfor POU6F1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: PO6F1_HUMAN, Q14863 Function : Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3') (Bysimilarity)
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Genomic Viewsfor POU6F1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_029419.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the POU6F1 gene promoter:E2F-4 E2F-3a E2F-5 Nkx2-5 E2F-2 CREB E2F E2F-1 deltaCREB c-Myb Other transcription factors Search SABiosciences Chromatin IP Primers for POU6F1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13 POU6F1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M051580: view genomic region
(about GC identifiers )
Start: 51,580,719 bp from pter End:
51,611,477 bp from pter
Size: 30,759 bases Orientation:
minus strand
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Proteinsfor POU6F1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PO6F1_HUMAN, Q14863 See
protein sequence )Recommended Name: Size : 301 amino acids; 32645 DaSubcellular location : Nucleus1 PDB 3D structure from :3D1N (3D) Secondary accessions : Q15944 Q6DK47 Q7Z7P6Explore the universe of human proteins at neXtProt for POU6F1: NX_Q14863 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q14863 POU6F1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_002693.3 ENSEMBL proteins: ENSP00000373895 ENSP00000330190 ENSP00000448389 ENSP00000448266 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
-- -- GO:0031965 nuclear membrane
IDA -- GO:0043231 intracellular membrane-bounded organelle
IDA --
About GeneDecksing POU6F1 Antibody Products: Assay Products for POU6F1:
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Protein
Domains /for POU6F1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q14863 ProtoNet protein and cluster: Q14863
2 Blocks protein families : IPB000327 IPB013847 UniProtKB/Swiss-Prot: PO6F1_HUMAN, Q14863 Similarity : Belongs to the POU transcription factor family. Class-6 subfamilySimilarity : Contains 1 homeobox DNA-binding domainSimilarity : Contains 1 POU-specific domain
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Functionfor POU6F1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: PO6F1_HUMAN, Q14863 Function : Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3') (Bysimilarity)
Genatlas biochemistry entry for POU6F1 POU domain,class 6,transcription factor 1,mammalian homeo box backfoot,Drosophila bicoid related,expressed in Rathke pouch,at an early stage of pituitary development and in a subset of adult anterior pituitary cells that express POMC Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: POU6F1 (NM_002702 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POU6F1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat POU6F1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU6F1
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding
-- -- GO:0003700 sequence-specific DNA binding transcription factor activity
IEA -- GO:0043565 sequence-specific DNA binding
IEA --
About GeneDecksing 1 GenomeRNAi human phenotype for POU6F1 :
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Pathways & Interactionsfor POU6F1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Transcription factors in neurogenesis
Pathway sources See GeneCards unified pathways Show all pathways 1 About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POU6F1 4 Interacting proteins for POU6F1 (Q14863 3 via UniProtKB, MINT, STRING, and/or I2D About this table Gene Ontology (GO): 5 biological process terms (GO ID links to tree view) : About this table
About GeneDecksing
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Drugs & Compoundsfor POU6F1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for POU6F1 POU6F1 / PO6F1
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Transcriptsfor POU6F1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for POU6F1 gene: NM_002702.3 Unigene Cluster for POU6F1:
POU class 6 homeobox 1 Hs.555886 [show with all ESTs ] Unigene Representative Sequence: NR_026893 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000389243 (uc001rxy.3 uc001rxz.3 uc001rya.3 ) ENST00000333640 ENST00000550824 ENST00000552305 ENST00000547855 ENST00000549309 ENST00000546685 ENST00000548692 ENST00000547854 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: POU6F1 (NM_002702 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for POU6F1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat POU6F1
Additional cDNA sequence: AL832881.1 BC051326.1 BC074765.2 BC107090.1 L14482.1 NR_026893.1 Z21966.1
11 DOTS entries : DT.211139 DT.100019233
DT.92416809 DT.100719359 DT.121124774 DT.411233 DT.86852017 DT.100804567 DT.65284314 DT.95231668 DT.40200606 24/36 AceView cDNA sequences (see all 36 ):
AF268617 BV207801 BV207798 BV199669 CA503120 AU123692 AA205845 BG569724 Z21964 CD048028 CD247950 CD048171 BQ278003 BV174940 AA216545 AA196616 AA232432 CD247215 BM830060 BM857157 AW438879 CD049202 AA176079 AA216743 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for POU6F1 (see all 6 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b SP1 : - - SP2 : - SP3 : SP4 : - - SP5 : -
ECgene alternative splicing isoforms for POU6F1
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Expression for POU6F1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section POU6F1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTGGAAGGAA
About this image POU6F1 expression in embryonic tissues and stem cells About this table See POU6F1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for POU6F1 SOURCE GeneReport for Unigene cluster: Hs.555886 UniProtKB/Swiss-Prot: PO6F1_HUMAN, Q14863 Tissue specificity : In the embryo, expressed exclusively in the developing brain, whereas in the adult its expressionis restricted to brain, heart, skeletal muscle and lung. In the brain, the highest expression levels are found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum SABiosciences Custom PCR Arrays for POU6F1 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU6F1
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Orthologsfor POU6F1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for POU6F1 gene from 3/12 species (see all 12 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
lizard Reptilia POU6F16
--
37(a)
1 ↔ 1
2(67513364-67531505)
tropical clawed frog Amphibia Str.130062
Transcribed sequence with strong similarity to protein more
80(n)
BX724095.1
zebrafish Actinopterygii pouc2
POU domain gene C
73.53(n)
30334 NM_131113.1
ENSEMBL Gene Tree for POU6F1 (if available)TreeFam Gene Tree for POU6F1 (if available)
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Paralogsfor POU6F1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for POU6F1 gene POU5F2 2 POU6F2 2 POU4F2 2 POU2F3 2 POU3F4 2 POU3F1 2 POU1F1 2 POU4F3 2 POU3F3 2 POU3F2 2 POU2F2 2 POU5F1B 2 POU2F1 2 POU4F1 2 POU5F1 2 18/82 SIMAP similar genes for POU6F1 using alignment to 3 protein entries: PO6F1_HUMAN (see all proteins )
(see all similar genes ):POU6F2 POU4F3 POU3F2 OCT6 POU3F1 OCT-2 POU2F3 POU3F3 POU4F2 POU1F1 POU4F1 POU5F1B POU5F1P4 POU2F1 POU3F4 LHX9 EN2 GSC About GeneDecksing
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Genomic Variantsfor POU6F1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 12 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for POU6F1 (51580719 - 51611477 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for POU6F1 1 CNV 47982 1 Indel 45057
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor POU6F1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing 2 : About MalaCards clear cell adenocarcinoma adenocarcinoma 1 disease from the University of Copenhagen DISEASES database for POU6F1 :Clear cell adenocarcinoma Export disorders for POU6F1 gene to outside databases
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Publicationsfor POU6F1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for POU6F1 gene, integrated from 9 sources (see all 16 ):(articles sorted by number of sources associating them with POU6F1) Utopia : connect your pdf to the dynamic
A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. (PubMed id 7908264) 1 , 2 , 3, 9(1994) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) A novel POU domain protein which binds to the T-cell receptor beta enhancer. (PubMed id 8102789) 1 , 2 (1993) Structure of human Brn-5 transcription factor in comp lex with CRH gene promoter. (PubMed id 19450691) 1 , 9(2009) Crystallization and preliminary X-ray analysis of human Brn-5 transcription factor in complex with DNA. (PubMed id 18323601) 1 , 9(2008) Transcription factor POU6F1 is important for prolifer ation of clear cell adenocarcinoma of the ovary and is a potential new molecula r target. (PubMed id 20134265) 1 (2010) POU6F1 is the transcription factor that might be invo lved in cell proliferation of clear cell adenocarcinoma of the ovary. (PubMed id 19874398) 1 (2009) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 (2008) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 (2004)
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External Searches for POU6F1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing POU6F1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing POU6F1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing POU6F1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for POU6F1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for POU6F1 gene: POU6F1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor POU6F1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for POU6F1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for POU6F1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for POU6F1 OriGene 3'-UTR Clone for POU6F1 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for POU6F1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for POU6F1 OriGene Custom Protein Services for POU6F1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POU6F1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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POU6F1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU6F1
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat POU6F1
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Aliases for POU6F1
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Expression for POU6F1
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Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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