Aliases for POU6F1 Gene
Aliases for POU6F1 Gene
External Ids for POU6F1 Gene
- HGNC: 9224
- Entrez Gene: 5463
- Ensembl: ENSG00000184271
- UniProtKB: Q14863
Previous GeneCards Identifiers for POU6F1 Gene
- GC12U990075
- GC12M051299
- GC12M049869
- GC12M051580
- GC12M048613
Summaries for POU6F1 Gene
GeneCards Summary for POU6F1 Gene
POU6F1 (POU Class 6 Homeobox 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is POU4F3.
UniProtKB/Swiss-Prot for POU6F1 Gene
-
Transcription factor that binds preferentially to a variant of the octamer motif (5-ATGATAAT-3).
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU6F1 Gene
Genomics for POU6F1 Gene
Regulatory Elements for POU6F1 Gene
Enhancers for POU6F1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around POU6F1 on UCSC Golden Path with GeneCards custom track
Promoters for POU6F1 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around POU6F1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for POU6F1 Gene
- Chromosome:
- 12
- Start:
- 51,186,936 bp from pter
- End:
- 51,217,693 bp from pter
- Size:
- 30,758 bases
- Orientation:
- Minus strand
Genomic View for POU6F1 Gene
Genes around POU6F1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by Ensembl
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC
POU6F1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POU6F1 Gene
Proteins for POU6F1 Gene
-
Protein details for POU6F1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14863-PO6F1_HUMAN
- Recommended name:
- POU domain, class 6, transcription factor 1
- Protein Accession:
- Q14863
- Q15944
- Q6DK47
- Q7Z7P6
Protein attributes for POU6F1 Gene
- Size:
- 301 amino acids
- Molecular mass:
- 32645 Da
- Quaternary structure:
- No Data Available
Protein Expression for POU6F1 Gene
Post-translational modifications for POU6F1 Gene
Other Protein References for POU6F1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for POU6F1
- Novus Biologicals Antibodies for POU6F1
- Abcam antibodies for POU6F1
- Invitrogen Antibodies for POU6F1
- antibodies-online Antibodies for POU6F1: See all 59
- GeneTex POU6F1 antibody for POU6F1
-
Santa Cruz Biotechnology (SCBT) Antibodies for POU6F1
Protein Products
-
OriGene Purified Proteins for POU6F1
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- ProSpec Recombinant Proteins for POU6F1
- antibodies-online Proteins for POU6F1: See all 8
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- Abcam proteins for POU6F1
Assay Products
No data available for DME Specific Peptides for POU6F1 Gene
Domains & Families for POU6F1 Gene
Gene Families for POU6F1 Gene
Protein Domains for POU6F1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for POU6F1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14863UniProtKB/Swiss-Prot:
PO6F1_HUMAN :- Contains 1 homeobox DNA-binding domain.
- Belongs to the POU transcription factor family. Class-6 subfamily.
- Domain:
-
- Contains 1 homeobox DNA-binding domain.
- Contains 1 POU-specific domain.
- Family:
-
- Belongs to the POU transcription factor family. Class-6 subfamily.
Function for POU6F1 Gene
Molecular function for POU6F1 Gene
- GENATLAS Biochemistry:
- POU domain,class 6,transcription factor 1,mammalian homeo box backfoot,Drosophila bicoid related,expressed in Rathke pouch,at an early stage of pituitary development and in a subset of adult anterior pituitary cells that express POMC
- UniProtKB/Swiss-Prot Function:
- Transcription factor that binds preferentially to a variant of the octamer motif (5-ATGATAAT-3).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for POU6F1 Gene
- GenomeRNAi human phenotypes for POU6F1:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression
Animal Model Products
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ViGene Biosciences lentiviral particle packaged cDNA for POU6F1 gene
-
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- Search ViGene Biosciences for POU6F1
CRISPR Products
-
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-
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miRNA for POU6F1 Gene
- miRTarBase miRNAs that target POU6F1
miRNA Products
- Search ViGene Biosciences for POU6F1
Clone Products
- OriGene clones in human for POU6F1
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Cell Line Products
-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POU6F1 Gene
Localization for POU6F1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for POU6F1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015629 | actin cytoskeleton | IDA | -- |
Pathways & Interactions for POU6F1 Gene
More details on SuperPathways for POU6F1
No Data Available
Interacting Proteins for POU6F1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007420 | brain development | TAS | 7908264 |
| GO:0007517 | muscle organ development | TAS | 7908264 |
No data available for Pathways by source and SIGNOR curated interactions for POU6F1 Gene
Transcripts for POU6F1 Gene
mRNA/cDNA for POU6F1 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (36) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for POU6F1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for POU6F1
-
Santa Cruz Biotechnology (SCBT) CRISPR for POU6F1
- GenScript: Design CRISPR guide RNA sequences for POU6F1
miRNA Products
- Search ViGene Biosciences for POU6F1
Clone Products
- OriGene clones in human for POU6F1
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- Sino Biological Human cDNA Clone for POU6F1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||
| SP6: | - | - |
Expression for POU6F1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Spinal Cord (Nervous System)
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for POU6F1 Gene
SOURCE GeneReport for Unigene cluster for POU6F1 Gene Hs.555886
mRNA Expression by UniProt/SwissProt for POU6F1 Gene
Q14863-PO6F1_HUMAN
Tissue specificity:
In the embryo, expressed exclusively in the developing brain, whereas in the adult its expression is restricted to brain, heart, skeletal muscle and lung. In the brain, the highest expression levels are found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for POU6F1
No data available for mRNA differential expression in normal tissues for POU6F1 Gene
Orthologs for POU6F1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | POU6F1 35 |
|
||
| POU6F1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | POU6F1 35 |
|
||
| POU6F1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Pou6f1 35 |
|
||
| Pou6f1 16 |
|
||||
| Pou6f1 36 |
|
OneToMany | |||
| POU6F1 36 |
|
OneToMany | |||
| chimpanzee (Pan troglodytes) |
Mammalia | POU6F1 35 |
|
||
| POU6F1 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Pou6f1 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | POU6F1 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | POU6F1 36 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | POU6F1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pou6f1 35 |
|
||
| Str.13006 35 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | pou6f1 35 |
|
||
| pouc 35 |
|
||||
| pou6f1 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG11641 37 |
|
|
- Species with no ortholog for POU6F1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for POU6F1 Gene
Paralogs for POU6F1 Gene
(77) SIMAP similar genes for POU6F1 Gene using alignment to 3 proteins:
- POU6F2
- POU4F3
- POU2F3
- POU3F2
- POU3F1
- OCT6
- OCT-2
- POU4F2
- POU3F3
- POU1F1
- POU4F1
- POU5F1B
- POU2F1
- POU5F1P4
- POU3F4
- LHX9
- POU5F2
- LHX5
- LHX1
- GSC
- EN2
- POU2F2
- POU5F1P1
- POU5F1
- ZFHX3
- PRRX2
- LHX8
- EN1
- ARGFX
- ZFHX2
- HESX1
- DPRX
- TPRX2P
- TPRX1
- OTX1
- MEOX2
- MEOX1
- LHX6
- VAX2
- VAX1
- PRRX1
- PROP1
- ESX1
- EMX2
- DLX5
- NANOGP8
- NANOGP1
- NANOG
- HOXB4
- CRX
- PITX3
- PITX2
- NKX6-3
- HOXD4
- HOXD12
- DUX5
- DUX4L9
- DUX4L7
- DUX4L6
- DUX4L5
- DUX4L4
- DUX4L3
- DUX4L2
- DUX4
- DLX3
- DLX2
- OTX2
- EMX1
- DUXA
- ZFHX4
- RAX
- PITX1
- HOXC4
- HOXA4
- DMBX1
- PBX2
- PAX4
Variants for POU6F1 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2067902 | -- | 51,204,126(-) | TGCCA(A/G)GTCCC | intron-variant | |
| rs1607 | -- | 51,187,165(+) | ACTCG(C/T)GTGTT | nc-transcript-variant, utr-variant-3-prime | |
| rs3490 | -- | 51,189,723(-) | AGGAC(C/T)TGGGA | nc-transcript-variant, utr-variant-3-prime | |
| rs11738 | -- | 51,187,224(+) | ATGCC(A/G)TGGTA | nc-transcript-variant, utr-variant-3-prime | |
| rs7136904 | -- | 51,192,355(+) | GTGGG(A/G)GTCTC | nc-transcript-variant, reference, synonymous-codon |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv34039 | CNV | Loss | 18971310 |
| esv2745877 | CNV | Deletion | 23290073 |
| esv2239902 | CNV | Deletion | 18987734 |
| esv2745878 | CNV | Deletion | 23290073 |
| esv2745879 | CNV | Deletion | 23290073 |
| esv1696566 | CNV | Insertion | 17803354 |
| esv2745880 | CNV | Deletion | 23290073 |
| esv2745881 | CNV | Deletion | 23290073 |
| esv2745882 | CNV | Deletion | 23290073 |
| esv2677962 | CNV | Deletion | 23128226 |
| nsv704 | CNV | Insertion | 18451855 |
Residual Variation Intolerance Score:
38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.66;
31.84% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for POU6F1 Gene
Disorders for POU6F1 Gene
Relevant External Links for POU6F1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- POU6F1
No disorders were found for POU6F1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POU6F1 Gene
Publications for POU6F1 Gene
- A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. (PMID: 7908264) Wey E. … Schaefer B.W. (Eur. J. Biochem. 1994) 2 3 4 23 67
- Structure of human Brn-5 transcription factor in complex with CRH gene promoter. (PMID: 19450691) Pereira J.H. … Kim S.H. (J. Struct. Biol. 2009) 3 23
- Crystallization and preliminary X-ray analysis of human Brn-5 transcription factor in complex with DNA. (PMID: 18323601) Pereira J.H. … Kim S.H. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2008) 3 23
- Transcription factor POU6F1 is important for proliferation of clear cell adenocarcinoma of the ovary and is a potential new molecular target. (PMID: 20134265) Suzuki N. … Ishizuka B. (Int. J. Gynecol. Cancer 2010) 3
- POU6F1 is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary. (PMID: 19874398) Yoshioka N. … Ishizuka B. (Hum. Cell 2009) 3
Products for POU6F1 Gene
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- GeneTex POU6F1 antibody for POU6F1
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- ViGene Biosciences adenoviral particle packaged cDNA for POU6F1 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for POU6F1 gene
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Sources for POU6F1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
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- (136) Genetics Home Reference
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- (138) MedlinePlus
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- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon