POU6F1 Gene

Aliases
for POU6F1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC12U990075 GC12M051299 GC12M049869 GC12M048613

Summaries
for POU6F1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for POU6F1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000012.11  NC_018923.2  NT_029419.13  

SwitchGear Promoter luciferase reporter plasmids (see all 2): POU6F1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU6F1

POU6F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M051580:  view genomic region     (about GC identifiers)

Proteins
for POU6F1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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1 PDB 3D structure from and Proteopedia for POU6F1:

3D1N (3D)    

Explore the universe of human proteins at neXtProt for POU6F1: NX_Q14863

Explore proteomics data for POU6F1 at MOPED

Post-translational modifications: 

POU6F1 Human Recombinant Protein Products:

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POU6F1 Assay Products:

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Domains /
Families
for POU6F1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q14863

Find genes that share domains with POU6F1           About GenesLikeMe

Function
for POU6F1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

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		hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-106a hsa-miR-218-1* hsa-miR-301a hsa-miR-766 hsa-miR-764
		SwitchGear 3'UTR luciferase reporter plasmid: POU6F1 3' UTR sequence

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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU6F1

Localization
for POU6F1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for POU6F1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 5 biological process terms:    About this table

Drugs & Compounds
for POU6F1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for POU6F1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for POU6F1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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POU6F1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTGGAAGGAA

About this image

Brain (Nervous System)    fully expand to see all 7 entries
ganglion/cranial/facial VII
Neural Tube (Nervous System)
Primitive Spinal Cord
Spinal Cord (Nervous System)

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU6F1

Orthologs
for POU6F1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for POU6F1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for POU6F1 gene

POU5F2²  POU6F2²  POU4F2²  POU2F3²  POU3F1²  POU3F4²  POU1F1²  POU3F3²  

POU4F3²  POU3F2²  POU2F2²  POU5F1B²  POU4F1²  POU2F1²  POU5F1²  

Selected SIMAP similar genes for POU6F1 using alignment to 3 protein entries:     PO6F1_HUMAN (see all proteins) (see all similar genes):

POU6F2    POU4F3    POU2F3    POU3F2    OCT6    POU3F1

OCT-2    POU3F3    POU4F2    POU1F1    POU4F1    POU2F1

POU5F1B    POU5F1P4    POU3F4    LHX9    EN2    GSC

Find genes that share paralogs with POU6F1           About GenesLikeMe

Genomic Variants
for POU6F1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for POU6F1 (see all 608)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1922152461,2		--	48626932(+)	TGTAAA/GGACTG	1	--	us2k1		0	--	--	--	--
rs107834181,2	C,F,A,H	--	51580219(+)	GCTCTT/CATCAG	2	--	ds5001		23		NS EA NA WA CSA	2342
rs1430268841,2	C	--	51580225(+)	ATCAGA/GCATCG	2	--	ds5001		0	--	--	--	--
rs1913415261,2		--	51580308(+)	AGGCAC/TTGAGT	2	--	ds5001		0	--	--	--	--
rs1165358301,2	C,F	--	51580459(+)	CTAGGT/CATAAG	2	--	ds5001		1		WA	118
rs1826330141,2		--	51580468(+)	AGAAGC/GGTGTT	2	--	ds5001		0	--	--	--	--
rs1481952601,2		--	51580618(+)	TTTTCC/TAGGCT	2	--	ds5001		0	--	--	--	--
rs111697521,2	C,F,A,H	--	51580707(+)	GGAAAC/AAAGCA	2	--	ds5001		19		NS EA NA CSA WA	2344
rs1411889981,2	C	--	51580732(+)	AAAAAA/TTACTG	2	--	ut31 nc-transcript-variant		0	--	--	--	--
rs769283551,2	C,F	--	51580947(+)	AACTCG/ATGTGT	2	--	ut31 nc-transcript-variant		1		WA	118

HapMap Linkage Disequilibrium report for POU6F1 (51580719 - 51611477 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for POU6F1 (see all 11):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2677962	CNV	Deletion	23128226
esv2745877	CNV	Deletion	23290073
esv2745881	CNV	Deletion	23290073
esv2239902	CNV	Deletion	18987734
esv2745878	CNV	Deletion	23290073
esv2745880	CNV	Deletion	23290073
esv2745879	CNV	Deletion	23290073
esv2745882	CNV	Deletion	23290073
nsv704	CNV	Insertion	18451855
esv1696566	CNV	Insertion	17803354

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing POU6F1

DNA2.0 Custom Variant and Variant Library Synthesis for POU6F1

Disorders / Diseases
for POU6F1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for POU6F1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. (PubMed id 7908264)^{1, 2, 3, 9} Wey E.... Schaefer B.W. (Eur. J. Biochem. 1994)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
3. A novel POU domain protein which binds to the T-cell receptor beta enhancer. (PubMed id 8102789)^{1, 2} Messier H.... Fotedar A. (Mol. Cell. Biol. 1993)
4. Structure of human Brn-5 transcription factor in complex with CRH gene promoter. (PubMed id 19450691)^{1, 9} Pereira J.H. and Kim S.H. (J. Struct. Biol. 2009)
5. Crystallization and preliminary X-ray analysis of human Brn-5 transcription factor in complex with DNA. (PubMed id 18323601)^{1, 9} Pereira J.H....Kim S.H. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2008)
6. Transcription factor POU6F1 is important for proliferation of clear cell adenocarcinoma of the ovary and is a potential new molecular target. (PubMed id 20134265)¹ Suzuki N....Ishizuka B. (Int. J. Gynecol. Cancer 2010)
7. POU6F1 is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovary. (PubMed id 19874398)¹ Yoshioka N....Ishizuka B. (Hum. Cell 2009)
8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (amp 2008)
9. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)¹ Zhou H....Espeseth A.S. (amp 2008)
10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)

External Searches for POU6F1 gene

Genome Databases showing POU6F1 gene

Other Databases showing POU6F1 gene

Specialized Databases showing POU6F1 gene

Products
for POU6F1 gene

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Advanced Cell Diagnostics, Animal models from genOway)
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