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Aliases for POU6F1 Gene

Aliases for POU6F1 Gene

  • POU Class 6 Homeobox 1 2 3
  • Brain-Specific Homeobox/POU Domain Protein 5 3 4
  • POU Domain, Class 6, Transcription Factor 1 2 3
  • MPOU Homeobox Protein 3 4
  • Brain-5 3 4
  • Brn-5 3 4
  • TCFB1 3 4
  • BRN5 3 4
  • MPOU 3 4

External Ids for POU6F1 Gene

Previous GeneCards Identifiers for POU6F1 Gene

  • GC12U990075
  • GC12M051299
  • GC12M049869
  • GC12M051580
  • GC12M048613

Summaries for POU6F1 Gene

GeneCards Summary for POU6F1 Gene

POU6F1 (POU Class 6 Homeobox 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is POU4F3.

UniProtKB/Swiss-Prot for POU6F1 Gene

  • Transcription factor that binds preferentially to a variant of the octamer motif (5-ATGATAAT-3).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU6F1 Gene

Genomics for POU6F1 Gene

Regulatory Elements for POU6F1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for POU6F1 Gene

51,186,936 bp from pter
51,217,693 bp from pter
30,758 bases
Minus strand

Genomic View for POU6F1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POU6F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU6F1 Gene

Proteins for POU6F1 Gene

  • Protein details for POU6F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    POU domain, class 6, transcription factor 1
    Protein Accession:
    Secondary Accessions:
    • Q15944
    • Q6DK47
    • Q7Z7P6

    Protein attributes for POU6F1 Gene

    301 amino acids
    Molecular mass:
    32645 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for POU6F1 Gene

neXtProt entry for POU6F1 Gene

Proteomics data for POU6F1 Gene at MOPED

Post-translational modifications for POU6F1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU6F1 Gene

No data available for DME Specific Peptides for POU6F1 Gene

Domains for POU6F1 Gene

Gene Families for POU6F1 Gene

  • POU :Homeoboxes / POU class

Protein Domains for POU6F1 Gene

Suggested Antigen Peptide Sequences for POU6F1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q14863
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 POU-specific domain.
  • Belongs to the POU transcription factor family. Class-6 subfamily.
genes like me logo Genes that share domains with POU6F1: view

Function for POU6F1 Gene

Molecular function for POU6F1 Gene

GENATLAS Biochemistry: POU domain,class 6,transcription factor 1,mammalian homeo box backfoot,Drosophila bicoid related,expressed in Rathke pouch,at an early stage of pituitary development and in a subset of adult anterior pituitary cells that express POMC
UniProtKB/Swiss-Prot Function: Transcription factor that binds preferentially to a variant of the octamer motif (5-ATGATAAT-3).

Gene Ontology (GO) - Molecular Function for POU6F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with POU6F1: view

Phenotypes for POU6F1 Gene

GenomeRNAi human phenotypes for POU6F1:
genes like me logo Genes that share phenotypes with POU6F1: view

Animal Model Products

CRISPR Products

miRNA for POU6F1 Gene

miRTarBase miRNAs that target POU6F1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POU6F1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for POU6F1 Gene

Localization for POU6F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU6F1 Gene

Subcellular locations from

Jensen Localization Image for POU6F1 Gene COMPARTMENTS Subcellular localization image for POU6F1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for POU6F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with POU6F1: view

Pathways for POU6F1 Gene

SuperPathways for POU6F1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for POU6F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007420 brain development TAS 7908264
GO:0007507 heart development TAS 7908264
GO:0007517 muscle organ development TAS 7908264
genes like me logo Genes that share ontologies with POU6F1: view

No data available for Pathways by source for POU6F1 Gene

Transcripts for POU6F1 Gene

Unigene Clusters for POU6F1 Gene

POU class 6 homeobox 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POU6F1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for POU6F1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POU6F1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - -
SP2: -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for POU6F1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POU6F1 Gene

mRNA expression in normal human tissues for POU6F1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for POU6F1 Gene

SOURCE GeneReport for Unigene cluster for POU6F1 Gene Hs.555886

mRNA Expression by UniProt/SwissProt for POU6F1 Gene

Tissue specificity: In the embryo, expressed exclusively in the developing brain, whereas in the adult its expression is restricted to brain, heart, skeletal muscle and lung. In the brain, the highest expression levels are found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum
genes like me logo Genes that share expressions with POU6F1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for POU6F1 Gene

Orthologs for POU6F1 Gene

This gene was present in the common ancestor of animals.

Orthologs for POU6F1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia POU6F1 35
  • 99.89 (n)
  • 100 (a)
POU6F1 36
  • 100 (a)
(Bos Taurus)
Mammalia POU6F1 35
  • 93.36 (n)
  • 98.67 (a)
POU6F1 36
  • 51 (a)
(Canis familiaris)
Mammalia POU6F1 35
  • 92.8 (n)
  • 98.67 (a)
POU6F1 36
  • 68 (a)
(Mus musculus)
Mammalia Pou6f1 35
  • 87.82 (n)
  • 95.35 (a)
Pou6f1 16
Pou6f1 36
  • 50 (a)
POU6F1 36
  • 95 (a)
(Monodelphis domestica)
Mammalia POU6F1 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia POU6F1 36
  • 58 (a)
(Rattus norvegicus)
Mammalia Pou6f1 35
  • 89.26 (n)
  • 96.35 (a)
(Anolis carolinensis)
Reptilia POU6F1 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pou6f1 35
  • 71.6 (n)
  • 79.8 (a)
Str.13006 35
(Danio rerio)
Actinopterygii pou6f1 35
  • 69.54 (n)
  • 74.83 (a)
pou6f1 36
  • 35 (a)
pouc 35
fruit fly
(Drosophila melanogaster)
Insecta CG11641 37
  • 70 (a)
Species with no ortholog for POU6F1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POU6F1 Gene

Gene Tree for POU6F1 (if available)
Gene Tree for POU6F1 (if available)

Paralogs for POU6F1 Gene

genes like me logo Genes that share paralogs with POU6F1: view

Variants for POU6F1 Gene

Sequence variations from dbSNP and Humsavar for POU6F1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1607 -- 51,187,165(+) ACTCG(C/T)GTGTT utr-variant-3-prime, nc-transcript-variant
rs3490 -- 51,189,723(-) AGGAC(C/T)TGGGA utr-variant-3-prime, nc-transcript-variant
rs11738 -- 51,187,224(+) ATGCC(A/G)TGGTA utr-variant-3-prime, nc-transcript-variant
rs1126902 -- 51,190,096(-) CAATG(C/T)CCCTC utr-variant-3-prime, nc-transcript-variant
rs1126904 -- 51,189,718(-) CTGGG(A/G)GATAA utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for POU6F1 Gene

Variant ID Type Subtype PubMed ID
esv34039 CNV Loss 18971310
esv2745877 CNV Deletion 23290073
esv2239902 CNV Deletion 18987734
esv2745878 CNV Deletion 23290073
esv2745879 CNV Deletion 23290073
esv1696566 CNV Insertion 17803354
esv2745880 CNV Deletion 23290073
esv2745881 CNV Deletion 23290073
esv2745882 CNV Deletion 23290073
esv2677962 CNV Deletion 23128226
nsv704 CNV Insertion 18451855

Relevant External Links for POU6F1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU6F1 Gene

Disorders for POU6F1 Gene

(1) University of Copenhagen DISEASES for POU6F1 Gene

genes like me logo Genes that share disorders with POU6F1: view

No data available for UniProtKB/Swiss-Prot for POU6F1 Gene

Publications for POU6F1 Gene

  1. A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. (PMID: 7908264) Wey E. … Schaefer B.W. (Eur. J. Biochem. 1994) 2 3 4 23
  2. Crystallization and preliminary X-ray analysis of human Brn-5 transcription factor in complex with DNA. (PMID: 18323601) Pereira J.H. … Kim S.H. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2008) 3 23
  3. Structure of human Brn-5 transcription factor in complex with CRH gene promoter. (PMID: 19450691) Pereira J.H. … Kim S.H. (J. Struct. Biol. 2009) 3 23
  4. A novel POU domain protein which binds to the T-cell receptor beta enhancer. (PMID: 8102789) Messier H. … Fotedar A. (Mol. Cell. Biol. 1993) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for POU6F1 Gene

Sources for POU6F1 Gene

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