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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

POU5F2 Gene

protein-coding GIFtS: 38
GCID: GC05M093102

POU Domain Class 5, Transcription Factor 2

Search for POU5F2
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
POU Domain Class 5, Transcription Factor 2¹ ²
Sperm 1 POU Domain Transcription Factor² ³
SPRM-1² ³
POU Domain, Class 5, Transcription Factor 2²
SPRM1³

External Ids:	HGNC: 26367¹	Entrez Gene: 134187²	Ensembl: ENSG00000248483⁷	UniProtKB: Q8N7G0³

Export aliases for POU5F2 gene to outside databases

Previous GC identifer: GC05M088248

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for POU5F2 Gene:

POU5F2 (POU domain class 5, transcription factor 2) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU6F2.

UniProtKB/Swiss-Prot: PO5F2_HUMAN, Q8N7G0

Function: Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory

function in meiotic events that are required for terminal differentiation of male germ cell (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.2 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the POU5F2 gene promoter:
Spz1 IRF-1 HEN1 E2F E2F-1 HSF2 HOXA5 Cart-1 TGIF En-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for POU5F2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU5F2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15 Ensembl cytogenetic band: 5q15 HGNC cytogenetic band: 5q15

POU5F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU5F2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M093102: view genomic region (about GC identifiers)

Start:	93,070,508 bp from pter	End:	93,077,343 bp from pter
Size:	6,836 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: PO5F2_HUMAN, Q8N7G0 (See protein sequence)

Recommended Name: POU domain, class 5, transcription factor 2

Size: 328 amino acids; 36051 Da

Subcellular location: Nucleus (By similarity)

Secondary accessions: Q15169 Q6MZL7 Q8N748

Explore the universe of human proteins at neXtProt for POU5F2: NX_Q8N7G0

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q8N7G0

POU5F2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : --

REFSEQ proteins: NP_694948.1

ENSEMBL proteins:

ENSP00000464890

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

POU5F2 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

POU: Homeoboxes / POU class

5 InterPro protein domains:

IPR010982 Lambda_DNA-bd_dom

IPR013847 POU

IPR000327 POU_specific

IPR001356 Homeodomain

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q8N7G0

ProtoNet protein and cluster: Q8N7G0

2 Blocks protein domains:

IPB000327 POU domain

IPB013847 POU

UniProtKB/Swiss-Prot: PO5F2_HUMAN, Q8N7G0

Similarity: Belongs to the POU transcription factor family. Class-5 subfamily

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 1 POU-specific domain

POU5F2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PO5F2_HUMAN, Q8N7G0

Function: Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory

function in meiotic events that are required for terminal differentiation of male germ cell (By similarity)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

POU5F2 for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pou5f2):

behavior/neurological

reproductive system

POU5F2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Pou5f2^tm1Rsd for POU5F2

inGenious Targeting Laboratory - Custom generated mouse model solutions for POU5F2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POU5F2

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for POU5F2

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--

POU5F2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Search CenterWatch for drugs/clinical trials and news about POU5F2 / PO5F2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for POU5F2 gene:

NM_153216.1

Unigene Cluster for POU5F2:

POU domain class 5, transcription factor 2

Hs.678995 [show with all ESTs]

Unigene Representative Sequence: BX641019

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000606183 ENST00000510627(uc003kkl.1)

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Additional mRNA sequence:

AK097970.1 AK098546.1 BC029532.1 BX641019.1 Z21965.1

2 DOTS entries:

DT.92023537 DT.100009090

12 AceView cDNA sequences:

NM_153216 Z21965 AK097970 BC029532 AK098546 BQ709766 BX641019 BI559739

BF979742 BP369993 BF980039 AV761918

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

POU5F2 expression in normal human tissues (normalized intensities) POU5F2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGGAAGCTGC

About this image

POU5F2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/1 selected tissues (see all 1) fully expand


Testis (Reproductive System)
Secondary Spermatocyte Seminiferous Tubules

Genevestigator expression for POU5F2

SOURCE GeneReport for Unigene cluster: Hs.678995

UniProtKB/Swiss-Prot: PO5F2_HUMAN, Q8N7G0

Tissue specificity: Expressed in skeletal and cardiac muscles, brain, heart and lung. Little or no detectable

expression found in pancreas, kidney, liver or placenta

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for POU5F2 gene from 10 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chimpanzee (Pan troglodytes)	Mammalia	POU5F2¹	POU domain class 5, transcription factor 2	98.88(n) 97.56(a)		737314 XM_001139199.2 XP_001139199.1
mouse (Mus musculus)	Mammalia	Pou5f2^{1 , 5}	POU domain class 5, transcription factor 2^{1, 5}	77.11(n)¹ 69.3(a)¹		13 (41.38 cM)⁵ 75507¹ NM_029315.1¹ NP_083591.1¹ 78022913⁵
rat (Rattus norvegicus)	Mammalia	Pou5f2¹	POU domain class 5, transcription factor 2	76.92(n) 68.32(a)		680620 NM_001081751.1 NP_001075220.1
oppossum (Monodelphis domestica)	Mammalia	-- --	Uncharacterized protein	50(a) 21(a)	1 ↔ many possible ortholog	2(267419431-267422270) 1(469389193-469422029)
platypus (Ornithorhynchus anatinus)	Mammalia	POU5F1⁶	POU domain, class 5, transcription factor 1	41(a)	1 → many	Contig22957(15451-15985)
chicken (Gallus gallus)	Aves	POUV⁶	POU domain class 5 transcription factor 1	29(a)	possible ortholog	17(460123-461472)
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	36(a)	1 → many	GL343623.1(305510-323263)
zebrafish (Danio rerio)	Actinopterygii	pou5f1⁶	POU domain, class 5, transcription factor 1	20(a)	possible ortholog	21(11887950-11892809)
sea squirt (Ciona savignyi)	Ascidiacea	CSA.1093⁶	Uncharacterized protein	9(a)	1 → many	reftig_41(1314919-1326878)
worm (Caenorhabditis elegans)	Secernentea	ceh-18⁶	Homeobox protein ceh-18	13(a)	1 → many	X(3843827-3857797)

Species with no ortholog for POU5F2

ENSEMBL Gene Tree for POU5F2 (if available)
TreeFam Gene Tree for POU5F2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for POU5F2 gene

POU6F2² POU4F2² POU2F3² POU3F1² POU3F4² POU1F1² POU3F3² POU4F3²

POU3F2² POU2F2² POU5F1B² POU4F1² POU2F1² POU6F1² POU5F1²

6 SIMAP similar genes for POU5F2 using alignment to 1 protein entry: PO5F2_HUMAN:

POU6F1 POU5F1P4 POU5F1 POU5F1B POU5F1P1 POU3F4

POU5F2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POU5F2

DNA2.0 Custom Variant and Variant Library Synthesis for POU5F2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for POU5F2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with POU5F2)

Utopia: connect your pdf to the dynamic
world of online information

A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. (PubMed id 7908264)^{1, 2, 3} Wey E.... Schaefer B.W. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 134187	HGNC: 26367	AceView: FLJ25680	Ensembl:ENSG00000248483	euGenes: HUgn134187
ECgene: POU5F2	H-InvDB: POU5F2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for POU5F2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for POU5F2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for POU5F2 gene:
Search GeneIP for patents involving POU5F2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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POU5F2 Gene

POU Domain Class 5, Transcription Factor 2

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POU5F2 Gene

POU Domain Class 5, Transcription Factor 2

Aliasesfor POU5F2 gene

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