Aliases for POU5F2 Gene
Aliases for POU5F2 Gene
External Ids for POU5F2 Gene
- HGNC: 26367
- Entrez Gene: 134187
- Ensembl: ENSG00000248483
- UniProtKB: Q8N7G0
Previous GeneCards Identifiers for POU5F2 Gene
- GC05M093102
- GC05M088248
Summaries for POU5F2 Gene
GeneCards Summary for POU5F2 Gene
POU5F2 (POU Domain Class 5, Transcription Factor 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is POU5F1.
UniProtKB/Swiss-Prot for POU5F2 Gene
-
Transcription factor that binds preferentially to the octamer motif (5-ATGTTAAT-3). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity).
Additional gene information for POU5F2 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU5F2 Gene
Genomics for POU5F2 Gene
GeneHancer (GH) Regulatory Elements for POU5F2 Gene
Promoters and enhancers for POU5F2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH05I093741 | Promoter | 0.7 | EPDnew | 550.8 | +0.0 | 17 | 0.1 | CTCF EGR1 | ENSG00000272406 POU5F2 NPM1P27 FAM172A | |
| GH05I093576 | Promoter/Enhancer | 2.8 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 11.8 | +158.6 | 158558 | 13.1 | MLX FEZF1 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 NFYC ZFP41 | NR2F1 NPM1P27 NR2F1-AS1 FAM172A POU5F2 MIR2277 ENSG00000251023 PIR38533 | |
| GH05I093715 | Enhancer | 0.7 | ENCODE | 0.3 | +25.6 | 25632 | 1.5 | PKNOX1 ZNF384 FEZF1 CTBP1 ZNF350 TCF7L2 MIXL1 ZNF362 GFI1B OVOL3 | ENSG00000251023 POU5F2 NPM1P27 FAM172A | |
| GH05I093720 | Enhancer | 0.6 | ENCODE | 0.3 | +20.0 | 20029 | 2.5 | PKNOX1 JUNB MNT BATF IRF4 PRDM6 ZNF341 HNF4A TCF7L2 | POU5F2 NPM1P27 FAM172A | |
| GH05I093717 | Enhancer | 0.5 | Ensembl | 0.3 | +24.3 | 24336 | 0.2 | OSR2 PRDM6 NFIA GLIS1 ZNF384 | POU5F2 NPM1P27 FAM172A |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around POU5F2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for POU5F2 Gene
Genomic Locations for POU5F2 Gene
- chr5:93,733,220-93,741,637
- (GRCh38/hg38)
- Size:
- 8,418 bases
- Orientation:
- Minus strand
- chr5:93,070,508-93,077,343
- (GRCh37/hg19)
Genomic View for POU5F2 Gene
Genes around POU5F2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q15 by Ensembl
- 5q15 by Entrez Gene
- 5q15 by HGNC
POU5F2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POU5F2 Gene
Proteins for POU5F2 Gene
-
Protein details for POU5F2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N7G0-PO5F2_HUMAN
- Recommended name:
- POU domain, class 5, transcription factor 2
- Protein Accession:
- Q8N7G0
- Q15169
- Q6MZL7
- Q8N748
Protein attributes for POU5F2 Gene
- Size:
- 328 amino acids
- Molecular mass:
- 36051 Da
- Quaternary structure:
- No Data Available
Protein Expression for POU5F2 Gene
Post-translational modifications for POU5F2 Gene
No Post-translational modifications
Other Protein References for POU5F2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for POU5F2
- Invitrogen Antibodies for POU5F2
- Search GeneTex for Antibodies for POU5F2
Protein Products
-
OriGene Purified Proteins for POU5F2
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- antibodies-online: Search results for 5 available POU5F2 Proteins ranked by validation data
- Compare Top POU5F2 Proteins
-
Quality Products:
- Search GeneTex for Proteins for POU5F2
-
Abcam proteins for POU5F2
Assay Products
No data available for DME Specific Peptides for POU5F2 Gene
Domains & Families for POU5F2 Gene
Gene Families for POU5F2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for POU5F2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for POU5F2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N7G0UniProtKB/Swiss-Prot:
PO5F2_HUMAN :- Belongs to the POU transcription factor family. Class-5 subfamily.
- Family:
-
- Belongs to the POU transcription factor family. Class-5 subfamily.
Function for POU5F2 Gene
Molecular function for POU5F2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that binds preferentially to the octamer motif (5-ATGTTAAT-3). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IEA | -- |
Phenotypes for POU5F2 Gene
- MGI mutant phenotypes for POU5F2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for POU5F2:
Animal Models for POU5F2 Gene
- MGI Knock Outs for POU5F2:
-
- Pou5f2 tm1Rsd
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for POU5F2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for POU5F2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for POU5F2 gene
- Search ViGene Biosciences for POU5F2
CRISPR Products
-
OriGene CRISPR knockouts for POU5F2
- genomics-online: gRNA clones - Search results for available POU5F2 gene related products
- Applied Biological Materials CRISPR for POU5F2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for POU5F2
- GenScript: Design CRISPR guide RNA sequences for POU5F2
miRNA Products
- Search ViGene Biosciences for POU5F2
Inhibitory RNA Products
- Origene shrna, RNAi, and sirna products in human, mouse, rat for POU5F2
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- genomics-online: shRNA clones - Search results for available POU5F2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for POU5F2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for POU5F2
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available POU5F2 gene related products
- orf clones - Search results for available POU5F2 gene related products
- Applied Biological Materials Clones for POU5F2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for POU5F2
-
ViGene Biosciences adenoviral particle packaged cDNA for POU5F2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for POU5F2 gene
-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for POU5F2 Gene
Localization for POU5F2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for POU5F2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for POU5F2 Gene
Pathways & Interactions for POU5F2 Gene
No Data Available
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for POU5F2 Gene
Transcripts for POU5F2 Gene
mRNA/cDNA for POU5F2 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (12) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for POU5F2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for POU5F2
- genomics-online: gRNA clones - Search results for available POU5F2 gene related products
- Applied Biological Materials CRISPR for POU5F2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for POU5F2
- GenScript: Design CRISPR guide RNA sequences for POU5F2
miRNA Products
- Search ViGene Biosciences for POU5F2
Inhibitory RNA Products
- Origene shrna, RNAi, and sirna products in human, mouse, rat for POU5F2
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- genomics-online: shRNA clones - Search results for available POU5F2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for POU5F2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for POU5F2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for POU5F2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available POU5F2 gene related products
- orf clones - Search results for available POU5F2 gene related products
- Applied Biological Materials Clones for POU5F2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for POU5F2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Secondary Spermatocyte Seminiferous Tubules
-
Gonad
- Secondary Spermatocyte Seminiferous Tubules
This gene is overexpressed in CD4 Tcells (45.8) and NK cells (23.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for POU5F2 Gene
NURSA nuclear receptor signaling pathways regulating expression of POU5F2 Gene:
POU5F2SOURCE GeneReport for Unigene cluster for POU5F2 Gene:
Hs.678995mRNA Expression by UniProt/SwissProt for POU5F2 Gene:
Q8N7G0-PO5F2_HUMAN
Tissue specificity:
Expressed in skeletal and cardiac muscles, brain, heart and lung. Little or no detectable expression found in pancreas, kidney, liver or placenta.
Evidence on tissue expression from TISSUES for POU5F2 Gene
- Muscle(4)
Primer Products
-
OriGene qPCR primer pairs for POU5F2
-
OriGene qPCR primer pairs and template standards for POU5F2
- genomics-online: primer clones - Search results for available POU5F2 gene related products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for POU5F2 Gene
Orthologs for POU5F2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | POU5F2 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pou5f2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Pou5f2 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | POU5F1 34 |
|
ManyToMany | |
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | POUV 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | zgc:158291 34 |
|
ManyToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | acj6 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | unc-86 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for POU5F2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for POU5F2 Gene
Paralogs for POU5F2 Gene
(6) SIMAP similar genes for POU5F2 Gene using alignment to 1 proteins:
Variants for POU5F2 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000514855 | -- | 93,740,683(-) | A/G | coding_sequence_variant, missense_variant | |
| rs1001396841 | -- | 93,741,841(-) | T/C | upstream_transcript_variant | |
| rs1001431201 | -- | 93,741,619(-) | A/G | upstream_transcript_variant | |
| rs1002407720 | -- | 93,740,253(-) | C/T | downstream_transcript_variant | |
| rs1002435202 | -- | 93,739,912(-) | T/A | downstream_transcript_variant |
Residual Variation Intolerance Score:
12.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.82;
17.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for POU5F2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- POU5F2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for POU5F2 Gene
Disorders for POU5F2 Gene
Additional Disease Information for POU5F2
No disorders were found for POU5F2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POU5F2 Gene
Publications for POU5F2 Gene
- A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. (PMID: 7908264) Wey E … Schäfer BW (European journal of biochemistry 1994) 2 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
Products for POU5F2 Gene
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- Invitrogen Antibodies for POU5F2
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 28 available POU5F2 Antibodies ranked by validation data
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- antibodies-online: Search results for available POU5F2 related products ranked by validation data
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Sources for POU5F2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
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