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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU5F2 Gene

protein-coding   GIFtS: 38
GCID: GC05M093102

POU domain class 5, transcription factor 2
  Search for POU5F2
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for POU5F2    

Aliases
for POU5F2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
POU Domain Class 5, Transcription Factor 21 2
SPRM-11 2 3
Sperm 1 POU Domain Transcription Factor2 3
FLJ256801
POU Domain, Class 5, Transcription Factor 22
SPRM13

External Ids:    HGNC: 263671   Entrez Gene: 1341872   Ensembl: ENSG000002484837   UniProtKB: Q8N7G03   

Export aliases for POU5F2 gene to outside databases

Previous GC identifer: GC05M088248


Summaries
for POU5F2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: PO5F2_HUMAN, Q8N7G0
Function: Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory
function in meiotic events that are required for terminal differentiation of male germ cell (By similarity)




Genomic Views
for POU5F2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU5F2 gene promoter:
         Spz1   IRF-1   HEN1   E2F   E2F-1   HSF2   HOXA5   Cart-1   TGIF   En-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for POU5F2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU5F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15   Ensembl cytogenetic band:  5q15   HGNC cytogenetic band: 5q15

POU5F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU5F2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M093102:  view genomic region     (about GC identifiers)

Start:
 93,075,976 bp from pter      End:
 93,077,309 bp from pter
Size:
 1,334 bases      Orientation:
 minus strand

Proteins
for POU5F2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PO5F2_HUMAN, Q8N7G0 (See protein sequence)
Recommended Name: POU domain, class 5, transcription factor 2  
Size: 328 amino acids; 36051 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q15169 Q6MZL7 Q8N748

Explore the universe of human proteins at neXtProt for POU5F2: NX_Q8N7G0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N7G0

    • POU5F2 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_694948.1  
    ENSEMBL proteins: 
     ENSP00000464890  

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    Uscn Proteins for POU5F2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    POU5F2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for POU5F2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    POU5F2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR010982 Lambda_DNA-bd_dom
     IPR013847 POU
     IPR000327 POU_specific
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q8N7G0

    ProtoNet protein and cluster: Q8N7G0

    2 Blocks protein families:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO5F2_HUMAN, Q8N7G0
    Similarity: Belongs to the POU transcription factor family. Class-5 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    Function
    for POU5F2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PO5F2_HUMAN, Q8N7G0
    Function: Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory
    function in meiotic events that are required for terminal differentiation of male germ cell (By similarity)

    miRNA
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    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--


    POU5F2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Pou5f2tm1Rsd for POU5F2
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pou5f2):
     behavior/neurological  reproductive system 

    POU5F2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for POU5F2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POU5F2

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--


    POU5F2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for POU5F2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POU5F2
    Search CenterWatch for drugs/clinical trials and news about POU5F2 / PO5F2 

    Transcripts
    for POU5F2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for POU5F2 gene: 
    NM_153216.1  

    Unigene Cluster for POU5F2:

    POU domain class 5, transcription factor 2
    Hs.678995  [show with all ESTs]
    Unigene Representative Sequence: BX641019
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000510627(uc003kkl.1)

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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU5F2
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    Additional cDNA sequence: 

    AK097970.1 AK098546.1 BC029532.1 BX641019.1 Z21965.1 

    2 DOTS entries:

    DT.92023537  DT.100009090 

    12 AceView cDNA sequences:

    AK097970 BC029532 NM_153216 Z21965 BQ709766 AK098546 BI559739 BX641019 
    BF979742 BP369993 BF980039 AV761918 

    GeneLoc Exon Structure


    Expression
    for POU5F2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU5F2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGAAGCTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    POU5F2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSecondary SpermatocyteGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    Genevestigator expression for POU5F2

    SOURCE GeneReport for Unigene cluster: Hs.678995

    UniProtKB/Swiss-Prot: PO5F2_HUMAN, Q8N7G0
    Tissue specificity: Expressed in skeletal and cardiac muscles, brain, heart and lung. Little or no detectable
    expression found in pancreas, kidney, liver or placenta

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    In Situ
    Assay Products:     
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    Orthologs
    for POU5F2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for POU5F2 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 35(a)
    		 1 → many
    		 GL343623.1(305954-310934)
    zebrafish
    (Danio rerio)    		 Actinopterygii pou5f16
    		 POU domain, class 5, transcription factor 1
    		 18(a)
    		 1 → many
    		 21(11887950-11892809)


    ENSEMBL Gene Tree for POU5F2 (if available)
    TreeFam Gene Tree for POU5F2 (if available) 

    Paralogs
    for POU5F2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POU5F2 gene
    POU6F22  POU4F22  POU2F32  POU3F42  POU3F12  POU1F12  POU4F32  POU3F32  
    POU3F22  POU2F22  POU5F1B2  POU2F12  POU4F12  POU5F12  POU6F12  
    6 SIMAP similar genes for POU5F2 using alignment to 1 protein entry:     PO5F2_HUMAN:
    POU6F1    POU5F1P4    POU5F1B    POU5F1P1    POU5F1    POU3F4

    POU5F2 for paralogs           About GeneDecksing



    Genomic Variants
    for POU5F2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POU5F2
    DNA2.0 Custom Variant and Variant Library Synthesis for POU5F2

    Disorders / Diseases
    for POU5F2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for POU5F2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU5F2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with POU5F2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. (PubMed id 7908264)1, 2, 3 Wey E.... Schaefer B.W. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for POU5F2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing POU5F2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 134187 HGNC: 26367 AceView: FLJ25680 Ensembl:ENSG00000248483 euGenes: HUgn134187
    ECgene: POU5F2 H-InvDB: POU5F2

    Other Databases showing POU5F2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing POU5F2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POU5F2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for POU5F2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for POU5F2 gene:
    Search GeneIP for patents involving POU5F2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for POU5F2 gene

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    Advanced Cell Diagnostics
    About This Section

     
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