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Aliases for POU5F2 Gene

Aliases for POU5F2 Gene

  • POU Domain Class 5, Transcription Factor 2 2 3
  • Sperm 1 POU Domain Transcription Factor 3 4
  • SPRM-1 3 4
  • POU Domain, Class 5, Transcription Factor 2 3
  • SPRM1 4

External Ids for POU5F2 Gene

Previous GeneCards Identifiers for POU5F2 Gene

  • GC05M093102
  • GC05M088248

Summaries for POU5F2 Gene

GeneCards Summary for POU5F2 Gene

POU5F2 (POU Domain Class 5, Transcription Factor 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is POU6F1.

UniProtKB/Swiss-Prot for POU5F2 Gene

  • Transcription factor that binds preferentially to the octamer motif (5-ATGTTAAT-3). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU5F2 Gene

Genomics for POU5F2 Gene

Regulatory Elements for POU5F2 Gene

Genomic Location for POU5F2 Gene

Start:
93,734,806 bp from pter
End:
93,741,637 bp from pter
Size:
6,832 bases
Orientation:
Minus strand

Genomic View for POU5F2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POU5F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU5F2 Gene

Proteins for POU5F2 Gene

  • Protein details for POU5F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7G0-PO5F2_HUMAN
    Recommended name:
    POU domain, class 5, transcription factor 2
    Protein Accession:
    Q8N7G0
    Secondary Accessions:
    • Q15169
    • Q6MZL7
    • Q8N748

    Protein attributes for POU5F2 Gene

    Size:
    328 amino acids
    Molecular mass:
    36051 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POU5F2 Gene

Proteomics data for POU5F2 Gene at MOPED

Post-translational modifications for POU5F2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU5F2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POU5F2 Gene

Domains for POU5F2 Gene

Gene Families for POU5F2 Gene

HGNC:
  • POU :Homeoboxes / POU class

Protein Domains for POU5F2 Gene

Suggested Antigen Peptide Sequences for POU5F2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N7G0

UniProtKB/Swiss-Prot:

PO5F2_HUMAN :
  • Q8N7G0
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 POU-specific domain.
Family:
  • Belongs to the POU transcription factor family. Class-5 subfamily.
genes like me logo Genes that share domains with POU5F2: view

Function for POU5F2 Gene

Molecular function for POU5F2 Gene

UniProtKB/Swiss-Prot Function: Transcription factor that binds preferentially to the octamer motif (5-ATGTTAAT-3). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity).

Gene Ontology (GO) - Molecular Function for POU5F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with POU5F2: view

Phenotypes for POU5F2 Gene

genes like me logo Genes that share phenotypes with POU5F2: view

Animal Models for POU5F2 Gene

MGI Knock Outs for POU5F2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POU5F2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for POU5F2 Gene

Localization for POU5F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU5F2 Gene

Gene Ontology (GO) - Cellular Components for POU5F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with POU5F2: view

No data available for Subcellular locations from COMPARTMENTS for POU5F2 Gene

Pathways for POU5F2 Gene

SuperPathways for POU5F2 Gene

No Data Available

Interacting Proteins for POU5F2 Gene

Gene Ontology (GO) - Biological Process for POU5F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with POU5F2: view

No data available for Pathways by source for POU5F2 Gene

Transcripts for POU5F2 Gene

mRNA/cDNA for POU5F2 Gene

(12) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POU5F2 Gene

POU domain class 5, transcription factor 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POU5F2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POU5F2 Gene

No ASD Table

Relevant External Links for POU5F2 Gene

GeneLoc Exon Structure for
POU5F2
ECgene alternative splicing isoforms for
POU5F2

Expression for POU5F2 Gene

mRNA expression in normal human tissues for POU5F2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for POU5F2 Gene

SOURCE GeneReport for Unigene cluster for POU5F2 Gene Hs.678995

mRNA Expression by UniProt/SwissProt for POU5F2 Gene

Q8N7G0-PO5F2_HUMAN
Tissue specificity: Expressed in skeletal and cardiac muscles, brain, heart and lung. Little or no detectable expression found in pancreas, kidney, liver or placenta.
genes like me logo Genes that share expressions with POU5F2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for POU5F2 Gene

Orthologs for POU5F2 Gene

This gene was present in the common ancestor of animals.

Orthologs for POU5F2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POU5F2 35
  • 98.88 (n)
  • 97.56 (a)
cow
(Bos Taurus)
Mammalia POU5F1 36
  • 46 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 46 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pou5f2 35
  • 75.5 (n)
  • 67.19 (a)
Pou5f2 16
Pou5f2 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pou5f2 35
  • 76.88 (n)
  • 68.11 (a)
chicken
(Gallus gallus)
Aves POUV 36
  • 28 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:158291 36
  • 22 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta acj6 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-86 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
OneToMany
Species with no ortholog for POU5F2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for POU5F2 Gene

ENSEMBL:
Gene Tree for POU5F2 (if available)
TreeFam:
Gene Tree for POU5F2 (if available)

Paralogs for POU5F2 Gene

Selected SIMAP similar genes for POU5F2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POU5F2: view

Variants for POU5F2 Gene

Relevant External Links for POU5F2 Gene

HapMap Linkage Disequilibrium report
POU5F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for POU5F2 Gene

Disorders for POU5F2 Gene

No disorders were found for POU5F2 Gene.

No data available for UniProtKB/Swiss-Prot for POU5F2 Gene

Publications for POU5F2 Gene

  1. A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. (PMID: 7908264) Wey E. … Schaefer B.W. (Eur. J. Biochem. 1994) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for POU5F2 Gene

Sources for POU5F2 Gene

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