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Aliases for POU5F2 Gene

Aliases for POU5F2 Gene

  • POU Domain Class 5, Transcription Factor 2 2 3 5
  • Sperm 1 POU Domain Transcription Factor 3 4
  • SPRM-1 3 4
  • POU Domain, Class 5, Transcription Factor 2 3
  • SPRM1 4

External Ids for POU5F2 Gene

Previous GeneCards Identifiers for POU5F2 Gene

  • GC05M093102
  • GC05M088248

Summaries for POU5F2 Gene

GeneCards Summary for POU5F2 Gene

POU5F2 (POU Domain Class 5, Transcription Factor 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is POU5F1.

UniProtKB/Swiss-Prot for POU5F2 Gene

  • Transcription factor that binds preferentially to the octamer motif (5-ATGTTAAT-3). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU5F2 Gene

Genomics for POU5F2 Gene

Regulatory Elements for POU5F2 Gene

Enhancers for POU5F2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F093676 0.7 Ensembl ENCODE 12.4 +64.2 64236 1.2 PKNOX1 SIN3A FEZF1 BRCA1 ZNF2 GLIS2 KLF7 ZNF263 SP3 REST ENSG00000272406 POU5F2 NPM1P27 ENSG00000278905
GH05F093576 1 FANTOM5 ENCODE 12.3 +160.0 160022 10.1 PKNOX1 MLX ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF416 ZNF143 ZNF548 NPM1P27 ENSG00000272406 POU5F2 MIR2277 NR2F1-AS1 ENSG00000251023 NR2F1 PIR38533
GH05F093597 1.3 FANTOM5 Ensembl ENCODE 12.3 +140.6 140572 7.2 PKNOX1 FEZF1 GLIS2 KLF7 ZNF263 SP3 TSHZ1 ZNF488 REST ZNF623 ENSG00000272406 POU5F2 NPM1P27 MIR2277 NR2F1 ENSG00000278905
GH05F093720 0.2 ENCODE 0.3 +20.0 20029 2.5 PKNOX1 ZNF341 HLF TCF7 JUNB FOS MNT TCF7L2 POU5F2 NPM1P27
GH05F093717 0.7 Ensembl 0.3 +24.3 24337 0.2 OSR2 NFIA GLIS1 ZNF384 POU5F2 NPM1P27
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around POU5F2 on UCSC Golden Path with GeneCards custom track

Genomic Location for POU5F2 Gene

Chromosome:
5
Start:
93,733,220 bp from pter
End:
93,741,637 bp from pter
Size:
8,418 bases
Orientation:
Minus strand

Genomic View for POU5F2 Gene

Genes around POU5F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POU5F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POU5F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU5F2 Gene

Proteins for POU5F2 Gene

  • Protein details for POU5F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7G0-PO5F2_HUMAN
    Recommended name:
    POU domain, class 5, transcription factor 2
    Protein Accession:
    Q8N7G0
    Secondary Accessions:
    • Q15169
    • Q6MZL7
    • Q8N748

    Protein attributes for POU5F2 Gene

    Size:
    328 amino acids
    Molecular mass:
    36051 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POU5F2 Gene

Post-translational modifications for POU5F2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU5F2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POU5F2 Gene

Domains & Families for POU5F2 Gene

Gene Families for POU5F2 Gene

Protein Domains for POU5F2 Gene

Suggested Antigen Peptide Sequences for POU5F2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N7G0

UniProtKB/Swiss-Prot:

PO5F2_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the POU transcription factor family. Class-5 subfamily.
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 POU-specific domain.
Family:
  • Belongs to the POU transcription factor family. Class-5 subfamily.
genes like me logo Genes that share domains with POU5F2: view

Function for POU5F2 Gene

Molecular function for POU5F2 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds preferentially to the octamer motif (5-ATGTTAAT-3). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity).

Gene Ontology (GO) - Molecular Function for POU5F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with POU5F2: view
genes like me logo Genes that share phenotypes with POU5F2: view

Animal Models for POU5F2 Gene

MGI Knock Outs for POU5F2:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for POU5F2 Gene

Localization for POU5F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU5F2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POU5F2 Gene COMPARTMENTS Subcellular localization image for POU5F2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for POU5F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with POU5F2: view

Pathways & Interactions for POU5F2 Gene

SuperPathways for POU5F2 Gene

No Data Available

Interacting Proteins for POU5F2 Gene

Selected Interacting proteins: Q8N7G0-PO5F2_HUMAN for POU5F2 Gene via IID

Gene Ontology (GO) - Biological Process for POU5F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with POU5F2: view

No data available for Pathways by source and SIGNOR curated interactions for POU5F2 Gene

Transcripts for POU5F2 Gene

mRNA/cDNA for POU5F2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POU5F2 Gene

POU domain class 5, transcription factor 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POU5F2 Gene

No ASD Table

Relevant External Links for POU5F2 Gene

GeneLoc Exon Structure for
POU5F2
ECgene alternative splicing isoforms for
POU5F2

Expression for POU5F2 Gene

mRNA expression in normal human tissues for POU5F2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POU5F2 Gene

This gene is overexpressed in CD4 Tcells (45.8) and NK cells (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for POU5F2 Gene



Protein tissue co-expression partners for POU5F2 Gene

NURSA nuclear receptor signaling pathways regulating expression of POU5F2 Gene:

POU5F2

SOURCE GeneReport for Unigene cluster for POU5F2 Gene:

Hs.678995

mRNA Expression by UniProt/SwissProt for POU5F2 Gene:

Q8N7G0-PO5F2_HUMAN
Tissue specificity: Expressed in skeletal and cardiac muscles, brain, heart and lung. Little or no detectable expression found in pancreas, kidney, liver or placenta.
genes like me logo Genes that share expression patterns with POU5F2: view

Primer Products

No data available for mRNA differential expression in normal tissues for POU5F2 Gene

Orthologs for POU5F2 Gene

This gene was present in the common ancestor of animals.

Orthologs for POU5F2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POU5F2 34
  • 98.88 (n)
rat
(Rattus norvegicus)
Mammalia Pou5f2 34
  • 76.88 (n)
mouse
(Mus musculus)
Mammalia Pou5f2 34 16 35
  • 75.5 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 50 (a)
OneToMany
cow
(Bos Taurus)
Mammalia POU5F1 35
  • 46 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves POUV 35
  • 28 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:158291 35
  • 22 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta acj6 35
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-86 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 16 (a)
OneToMany
Species where no ortholog for POU5F2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for POU5F2 Gene

ENSEMBL:
Gene Tree for POU5F2 (if available)
TreeFam:
Gene Tree for POU5F2 (if available)

Paralogs for POU5F2 Gene

(6) SIMAP similar genes for POU5F2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POU5F2: view

Variants for POU5F2 Gene

Sequence variations from dbSNP and Humsavar for POU5F2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs111528856 -- 93,741,309(+) TCACT(A/G)GCTCC intron-variant, reference, synonymous-codon
rs112317301 -- 93,741,584(+) CGCAG(C/T)GGCTC intron-variant, utr-variant-5-prime
rs11375847 -- 93,741,911(+) CTGGA(-/C)CCCTG intron-variant, upstream-variant-2KB
rs114788162 -- 93,743,209(+) CCATC(A/G)CTACA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs115984342 -- 93,742,077(+) CAGTC(C/T)CTGTG intron-variant, upstream-variant-2KB

Variation tolerance for POU5F2 Gene

Residual Variation Intolerance Score: 12.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POU5F2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
POU5F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for POU5F2 Gene

Disorders for POU5F2 Gene

Relevant External Links for POU5F2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POU5F2

No disorders were found for POU5F2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POU5F2 Gene

Publications for POU5F2 Gene

  1. A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. (PMID: 7908264) Wey E. … Schaefer B.W. (Eur. J. Biochem. 1994) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for POU5F2 Gene

Sources for POU5F2 Gene

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