Set Analyses:
GeneALaCart
GeneDecks
VarElect
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 


POU5F1B Gene

protein-coding   GIFtS: 44
GCID: GC08P128426

POU Class 5 Homeobox 1B

(Previous names: POU domain class 5, transcription factor 1 pseudogene 1,...)
(Previous symbols: OTF3P1, POU5F1P1)
  See related diseases
at
MalaCards
 

Aliases
for POU5F1B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus
Aliases
POU Class 5 Homeobox 1B1 2     POU5F1P42
OTF3P11 2 3     Octamer Binding Protein 3_like Sequence2
POU5F1P11 2 3     POU 5 Domain Protein2
POU Class 5 Homeobox 1 Pseudogene 11 2     POU Domain Transcription Factor Oct-42
OTF3C2 3     POU Domain Transcription Factor OCT4-Pg12
POU5FLC202 3     POU Domain, Class 5, Transcription Factor 1 Pseudogene 12
POU5FLC82 3     Putative POU Domain, Class 5, Transcription Factor 1B2
POU Domain Class 5, Transcription Factor 1 Pseudogene 11     Octamer-Binding Protein 3-Like3
OCT4-PG12     Octamer-Binding Transcription Factor 3-Like3

External Ids:    HGNC: 92231   Entrez Gene: 54622   Ensembl: ENSG000002129937   UniProtKB: Q064163   

Export aliases for POU5F1B gene to outside databases

Previous GC identifers: GC08P128499 GC08P123746


Summaries
for POU5F1B gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus
Entrez Gene summary for POU5F1B Gene:
This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been
reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and
highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional
activator and may play a role in carcinogenesis and eye development. (provided by RefSeq, Apr 2009)

GeneCards Summary for POU5F1B Gene:
POU5F1B (POU class 5 homeobox 1B) is a protein-coding gene. Diseases associated with POU5F1B include gonadoblastoma, and teratoma. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: P5F1B_HUMAN, Q06416
Function: Shows weak transcriptional activator activity




Genomic Views
for POU5F1B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the POU5F1B gene promoter:
         STAT5B   AML1a   Pbx1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   CUTL1   Cdc5   POU3F2   Gfi-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for POU5F1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU5F1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.21   Ensembl cytogenetic band:  8q24.21   HGNC cytogenetic band: 8q24.21

POU5F1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU5F1B gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P128426:  view genomic region     (about GC identifiers)

Start:
 128,426,535 bp from pter      End:
 128,432,311 bp from pter
Size:
 5,777 bases      Orientation:
 plus strand

Proteins
for POU5F1B gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus
UniProtKB/Swiss-Prot: P5F1B_HUMAN, Q06416 (See protein sequence)
Recommended Name: Putative POU domain, class 5, transcription factor 1B  
Size: 359 amino acids; 38588 Da
Caution: Could be the product of a pseudogene. Several pseudogenes of POU5F1 have been described on chromosomes 1,
3, 8, 10 and 12. Two of them, localized on chromosomes 8 and 10 have been shown to be preferentially transcribed
in cancer tissues and may be involved in the regulation of POU5F1 gene activity in carcinogenesis
Secondary accessions: D5K9V4 Q2VIK6 Q9BZV7 Q9BZV9

Explore the universe of human proteins at neXtProt for POU5F1B: NX_Q06416

Explore proteomics data for POU5F1B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See POU5F1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001153014.1  
    ENSEMBL proteins: 
     ENSP00000419298   ENSP00000375557  

    POU5F1B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for POU5F1B
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for POU5F1B
    GenScript Custom Purified and Recombinant Proteins Services for POU5F1B
    Novus Biologicals POU5F1B Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for POU5F1B

    POU5F1B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for POU5F1B
    OriGene Custom Antibody Services for POU5F1B
    Abcam antibodies for POU5F1B
    Cloud-Clone Corp. Antibodies for POU5F1B
    ThermoFisher Antibodies for POU5F1B
    LSBio Antibodies in human, mouse, rat for POU5F1B

    POU5F1B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for POU5F1B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POU5F1B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for POU5F1B
    Cloud-Clone Corp. CLIAs for POU5F1B

    Domains /
    Families
    for POU5F1B gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    POU: Homeoboxes / POU class

    Selected InterPro protein domains (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry Q06416

    ProtoNet protein and cluster: Q06416

    2 Blocks protein domains:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: P5F1B_HUMAN, Q06416
    Similarity: Belongs to the POU transcription factor family. Class-5 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    POU5F1B for domains           About GeneDecksing


    Function
    for POU5F1B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P5F1B_HUMAN, Q06416
    Function: Shows weak transcriptional activator activity

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS1408763
    GO:0043565sequence-specific DNA binding IEA--
         
    POU5F1B for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POU5F1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for POU5F1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU5F1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU5F1B

    miRNA
    Products:            		Block miRNA regulation of human, mouse, rat POU5F1B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate POU5F1B
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for POU5F1B
    Predesigned siRNA for gene silencing in human, mouse, rat POU5F1B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for POU5F1B

    Clone
    Products:             		 OriGene clones in human, mouse for POU5F1B (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POU5F1B (NM_001159542)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU5F1B
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat POU5F1B

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for POU5F1B
    Browse ESI BIO Cell Lines and PureStem Progenitors for POU5F1B 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU5F1B


    Localization
    for POU5F1B gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
    Subcellular locations from UniProtKB/Swiss-Prot
    P5F1B_HUMAN, Q06416: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    POU5F1B for ontologies           About GeneDecksing


    Pathways & Interactions
    for POU5F1B gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POU5F1B
    Interactions:

        Search GeneGlobe Interaction Network for POU5F1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for POU5F1B (ENSP000003755574) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NANOGENSP000002293074STRING: ENSP00000229307
    ARID3BENSP000003431264STRING: ENSP00000343126
    GATAD2BENSP000003576444STRING: ENSP00000357644
    MTA2ENSP000002788234STRING: ENSP00000278823
    MTA1ENSP000003336334STRING: ENSP00000333633
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated NAS1408763

    POU5F1B for ontologies           About GeneDecksing



    Drugs & Compounds
    for POU5F1B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POU5F1B (P5F1B)



    Transcripts
    for POU5F1B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus
    REFSEQ mRNAs for POU5F1B gene: 
    NM_001159542.1  

    Unigene Cluster for POU5F1B:

    POU class 5 homeobox 1B
    Hs.450254  [show with all ESTs]
    Unigene Representative Sequence: DQ486513
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465342 ENST00000391675(uc003ysf.3)
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat POU5F1B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate POU5F1B
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for POU5F1B
    Predesigned siRNA for gene silencing in human, mouse, rat POU5F1B
    Clone
    Products:             		 OriGene clones in human, mouse for POU5F1B (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: POU5F1B (NM_001159542)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU5F1B
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat POU5F1B
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for POU5F1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat POU5F1B
      QuantiTect SYBR Green Assays in human, mouse, rat POU5F1B
      QuantiFast Probe-based Assays in human, mouse, rat POU5F1B

    Additional mRNA sequence: 

    AF268615.1 AF268618.1 DQ486513.1 FM177969.1 FM177970.1 FM177971.1 FM177972.1 FM177973.1 
    FM177974.1 FM177975.1 FM177976.1 FM177977.1 FM177978.1 FM177979.1 FM177980.1 FM177981.1 
    FM177982.1 

    2 DOTS entries:

    DT.100791937  DT.75142423 

    Selected AceView cDNA sequences (see all 32):

    AF268615 BX108223 AF268618 BV207915 CB144537 BM817496 BV207913 BV199595 
    BM796771 BV207916 BV207917 CD247012 AA196616 BM857157 CD049748 CD049560 
    BG656494 BV199596 AA480280 CD048739 AA232432 BM830060 BV199667 AA515288 

    GeneLoc Exon Structure


    Expression
    for POU5F1B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    POU5F1B expression in normal human tissues (normalized intensities)      POU5F1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    POU5F1B Expression
    About this image


    POU5F1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 14 entries
             hIPS1
             ESI-051   
     
     NULL (Uncategorized)
             Mesenchymal Progenitor Cells - Passage 2
    POU5F1B Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    POU5F1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.450254
        Custom PCR Arrays for POU5F1B
    Primer
    Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for POU5F1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat POU5F1B
    QuantiTect SYBR Green Assays in human, mouse, rat POU5F1B
    QuantiFast Probe-based Assays in human, mouse, rat POU5F1B
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU5F1B

    Orthologs
    for POU5F1B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus
    This gene was present in the common ancestor of animals.

    Orthologs for POU5F1B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves POUV6
    		 Gallus gallus POU domain class 5 transcription fac...
    		 39(a)
    		 1 → many
    		 17(460123-461472)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 Uncharacterized protein
    		 55(a)
    		 1 → many
    		 GL343623.1(305510-323263)
    zebrafish
    (Danio rerio)    		 Actinopterygii pou5f36
    		 POU domain, class 5, transcription factor 3
    		 28(a)
    		 1 → many
    		 21(11887950-11892809) ENSDARG00000044774
    fruit fly
    (Drosophila melanogaster)    		 Insecta acj66
    		 abnormal chemosensory jump 6
    		 22(a)
    		 1 → many
    		 X(15245315-15272487)
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-866
    		 Protein UNC-86, isoform a (unc-86) mRNA, complete ...
    		 25(a)
    		 1 → many
    		 III(8212758-8216336) WBGene00006818
            Species with no ortholog for POU5F1B

    ENSEMBL Gene Tree for POU5F1B (if available)
    TreeFam Gene Tree for POU5F1B (if available)

    Paralogs
    for POU5F1B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for POU5F1B gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F12  POU3F42  POU1F12  POU3F32  
    POU4F32  POU3F22  POU2F22  POU4F12  POU2F12  POU6F12  POU5F12  
    12 SIMAP similar genes for POU5F1B using alignment to 1 protein entry:     P5F1B_HUMAN:
    POU5F1P1    POU5F1    POU5F1P3    POU5F1P4    POU6F1    POU3F4
    POU5F2    POU1F1    POU2F2    POU2F1    POU3F2    POU3F1

    POU5F1B for paralogs           About GeneDecksing



    Genomic Variants
    for POU5F1B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Selected SNPs for POU5F1B (see all 116)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs796112401,2
    		C,F--128425906(+) AAGCAG/AAGCAT 1 -- us2k11Minor allele frequency- A:0.01MN 156
    rs1419396211,2
    		--128425919(+) CCTCAA/GACGAT 1 -- us2k10--------
    rs800553061,2
    		C,F--128426003(+) ACTTTT/ACTGCT 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs2017539801,2
    		--128426100(+) AGGTG-/GTGTACA 1 -- us2k10--------
    rs751701461,2
    		C--128426103(+) GTGGTA/GCACAC 1 -- us2k10--------
    rs39997761,2
    		C--128426125(+) acaca-/CA/   
      CACACA    NNNNN     		2 -- us2k1 cds11NA 2
    rs780982571,2
    		C,F--128426196(+) GAAGTT/GAATGA 1 -- us2k12Minor allele frequency- G:0.05MN NA 246
    rs1507041771,2
    		C--128426369(+) TATCTA/GTCTTA 1 -- us2k10--------
    rs8711351,2
    		C,F,A,H--128426393(+) AGAACT/GTCAAA 1 -- us2k118Minor allele frequency- G:0.43NS EA NA WA MN CSA 1190
    rs1842002931,2
    		C--128426433(+) GAGAAC/TGTTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for POU5F1B (128426535 - 128432311 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for POU5F1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv499795OTHER Inversion21111241
    nsv7419OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): POU5F1B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POU5F1B
    DNA2.0 Custom Variant and Variant Library Synthesis for POU5F1B

    Disorders / Diseases
    for POU5F1B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 8 diseases for POU5F1B:    About MalaCards
    gonadoblastoma    teratoma    chronic lymphocytic leukemia    colorectal cancer
    prostate cancer    prostatitis    ovarian cancer    leukemia

    1 disease from the University of Copenhagen DISEASES database for POU5F1B:
    Teratoma

    POU5F1B for disorders           About GeneDecksing

    Genetic Association Database (GAD): POU5F1B
    Human Genome Epidemiology (HuGE) Navigator: POU5F1B (1 document)

    Export disorders for POU5F1B gene to outside databases

    Publications
    for POU5F1B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus
    PubMed articles for POU5F1B gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with POU5F1B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. (PubMed id 1408763)1, 2, 3 Takeda J.... Bell G.I. (Nucleic Acids Res. 1992)
    2. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PubMed id 22041458)1, 4 Clark S.L....van den Oord E.J. (Psychol Med 2012)
    3. The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1. (PubMed id 18949397)1, 2 Panagopoulos I.... Mertens F. (Oncol. Rep. 2008)
    4. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. (PubMed id 17401366)1, 4 Gudmundsson J....Stefansson K. (Nat. Genet. 2007)
    5. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. (PubMed id 17401363)1, 4 Yeager M....Thomas G. (Nat. Genet. 2007)
    6. Emergence of young human genes after a burst of retroposition in primates. (PubMed id 16201836)1, 2 Marques A.C.... Kaessmann H. (PLoS Biol. 2005)
    7. A diabetic milieu promotes OCT4 and NANOG production in human visceral-derived adipose stem cells. (PubMed id 23064289)1 Dentelli P....Brizzi M.F. (Diabetologia 2013)
    8. Differential expression of Oct4 variants and pseudogenes in normal urothelium and urothelial cancer. (PubMed id 23933063)1 Wezel F....Southgate J. (Am. J. Pathol. 2013)
    9. Genome-wide association study identifies new prostate cancer susceptibility loci. (PubMed id 21743057)4 Schumacher F.R....Kraft P. (Hum. Mol. Genet. 2011)
    10. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. (PubMed id 20972438)4 Rothman N....Chanock S.J. (Nat. Genet. 2010)

    External Searches for POU5F1B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing POU5F1B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5462 HGNC: 9223 AceView: POU5F1P1 Ensembl:ENSG00000212993 euGenes: HUgn5462
    ECgene: POU5F1B H-InvDB: POU5F1B

    Other Databases showing POU5F1B gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing POU5F1B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for POU5F1B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for POU5F1B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for POU5F1B gene:
    Search GeneIP for patents involving POU5F1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for POU5F1B gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for POU5F1B   OriGene RNAi products in human, mouse, rat for POU5F1B  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for POU5F1B  
     OriGene qSTAR qPCR primer pairs in human, mouse for POU5F1B   OriGene Purified Protein for POU5F1B  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for POU5F1B   OriGene Custom Protein Services for POU5F1B  

         		 
     Block miRNA regulation of human, mouse, rat POU5F1B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing POU5F1B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU5F1B Predesigned siRNA for gene silencing in human, mouse, rat POU5F1B
     QuantiFast Probe-based Assays in human, mouse, rat POU5F1B QuantiTect SYBR Green Assays in human, mouse, rat POU5F1B
     Custom PCR Arrays for POU5F1B Search Chromatin IP Primers for POU5F1B
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat POU5F1B  Search GeneGlobe Interaction Network for POU5F1B
     Regulatory tfbs in POU5F1B promoter
     GenScript Custom Purified and Recombinant Proteins Services for POU5F1B GenScript cDNA clones with any tag delivered in your preferred vector for POU5F1B
     GenScript Custom Assay Services for POU5F1B GenScript Custom overexpressing Cell Line Services for POU5F1B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for POU5F1B (P5F1B)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     POU5F1B proteins
     Antibodies for POU5F1B
     See all of Abcam's Antibodies, Kits and Proteins for POU5F1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for POU5F1B
     Antibodies for POU5F1B
     ELISAs for POU5F1B
     CLIAs for POU5F1B



     Browse ESI BIO Cell Lines and PureStem Progenitors for POU5F1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU5F1B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for POU5F1B
     Browse SwitchGear Promoter luciferase reporter plasmids for POU5F1B
     ThermoFisher Antibodies for POU5F1B
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat POU5F1B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POU5F1B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for POU5F1B
     LSBio Antibodies in human, mouse, rat for POU5F1B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      POU5F1B gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4