Aliases for POU5F1B Gene
Aliases for POU5F1B Gene
- POU Domain Class 5, Transcription Factor 1 Pseudogene 1 2
- Putative POU Domain, Class 5, Transcription Factor 1B 3
- Octamer-Binding Transcription Factor 3-Like 4
- POU Domain Transcription Factor OCT4-Pg1 3
- Octamer Binding Protein 3_like Sequence 3
- POU Domain Transcription Factor Oct-4 3
- Octamer-Binding Protein 3-Like 4
- POU 5 Domain Protein 3
- POU5F1P4 3
External Ids for POU5F1B Gene
- HGNC: 9223
- Entrez Gene: 5462
- Ensembl: ENSG00000212993
- OMIM: 615739
- UniProtKB: Q06416
Previous HGNC Symbols for POU5F1B Gene
- OTF3P1
- POU5F1P1
Previous GeneCards Identifiers for POU5F1B Gene
- GC08P128499
- GC08P123746
- GC08P128426
Summaries for POU5F1B Gene
-
This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009]
GeneCards Summary for POU5F1B Gene
POU5F1B (POU Class 5 Homeobox 1B) is a Protein Coding gene. Among its related pathways are Signaling pathways regulating pluripotency of stem cells. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is POU5F1.
UniProtKB/Swiss-Prot for POU5F1B Gene
-
Shows weak transcriptional activator activity.
Additional gene information for POU5F1B Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU5F1B Gene
Genomics for POU5F1B Gene
GeneHancer (GH) Regulatory Elements for POU5F1B Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH08I127415 | Promoter | 0.5 | EPDnew | 550.8 | +1.5 | 1516 | 0.1 | POU5F1B CASC8 | ||
GH08I127426 | Enhancer | 0.6 | Ensembl ENCODE | 0.4 | +12.8 | 12848 | 1.8 | PKNOX1 CEBPG | CASC8 POU5F1B | |
GH08I127477 | Enhancer | 0.7 | Ensembl ENCODE | 0.2 | +64.6 | 64615 | 2.6 | GATA3 JUND POLR2A JUN FOSL2 FOS EP300 | CASC8 POU5F1B | |
GH08I127457 | Enhancer | 0.4 | Ensembl ENCODE | 0.3 | +44.1 | 44074 | 0.9 | CASC8 POU5F1B | ||
GH08I127471 | Enhancer | 0.5 | ENCODE | 0.2 | +58.4 | 58413 | 1.5 | FOXP2 EBF1 ZFX RUNX3 | CASC8 POU5F1B |
- Top Transcription factor binding sites by QIAGEN in the POU5F1B gene promoter:
Regulatory Element Products
Genomic Locations for POU5F1B Gene
- chr8:127,414,290-127,420,069
- (GRCh38/hg38)
- Size:
- 5,780 bases
- Orientation:
- Plus strand
- chr8:128,426,535-128,432,311
- (GRCh37/hg19)
Genomic View for POU5F1B Gene
- Cytogenetic band:
-
- 8q24.21 by Ensembl
- 8q24.21 by Entrez Gene
- 8q24.21 by HGNC


RefSeq DNA sequence for POU5F1B Gene
Proteins for POU5F1B Gene
-
Protein details for POU5F1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q06416-P5F1B_HUMAN
- Recommended name:
- Putative POU domain, class 5, transcription factor 1B
- Protein Accession:
- Q06416
- D5K9S4
- D5K9S9
- D5K9T0
- D5K9T1
- D5K9T3
- D5K9U3
- D5K9U6
- D5K9V4
- D5K9V6
- D5K9W0
- D5K9W2
- D5K9W7
- D5K9X2
- D5K9X3
- D5K9X5
- D5K9X8
- D5K9X9
- E9LRB1
- E9LRB2
- E9LRH5
- E9LRH6
- E9LRH7
- E9LRK4
- E9LRK5
- E9LRK7
- E9LRK8
- E9LRM7
- E9LRM9
- E9LRN2
- E9LRN4
- E9LRN5
- E9LRP8
- E9LRQ0
- E9LRQ2
- E9LRQ3
- E9LRQ4
- E9LRQ5
- E9LRS3
- Q2VIK6
- Q9BZV7
- Q9BZV9
Protein attributes for POU5F1B Gene
- Size:
- 359 amino acids
- Molecular mass:
- 38588 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for POU5F1B Gene
Other Protein References for POU5F1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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Assay Products
No data available for DME Specific Peptides for POU5F1B Gene
Domains & Families for POU5F1B Gene
Gene Families for POU5F1B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for POU5F1B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for POU5F1B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q06416UniProtKB/Swiss-Prot:
P5F1B_HUMAN :- Belongs to the POU transcription factor family. Class-5 subfamily.
- Family:
-
- Belongs to the POU transcription factor family. Class-5 subfamily.
Function for POU5F1B Gene
Molecular function for POU5F1B Gene
- UniProtKB/Swiss-Prot Function:
- Shows weak transcriptional activator activity.
Phenotypes From GWAS Catalog for POU5F1B Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003700 | DNA binding transcription factor activity | TAS | 1408763 |
GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for POU5F1B Gene
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miRNA for POU5F1B Gene
- miRTarBase miRNAs that target POU5F1B
-
- hsa-mir-7853-5p (MIRT526499)
- hsa-mir-105-5p (MIRT526500)
- hsa-mir-8485 (MIRT526501)
- hsa-mir-6848-3p (MIRT526502)
- hsa-mir-6843-3p (MIRT526503)
- hsa-mir-3663-5p (MIRT526504)
- hsa-mir-372-5p (MIRT526505)
- hsa-mir-371a-5p (MIRT526506)
- hsa-mir-616-5p (MIRT526507)
- hsa-mir-373-5p (MIRT526508)
- hsa-mir-371b-5p (MIRT526509)
- hsa-mir-4698 (MIRT526510)
- hsa-mir-8063 (MIRT526511)
- hsa-mir-3163 (MIRT526512)
- hsa-mir-590-3p (MIRT526513)
- hsa-mir-5692a (MIRT526514)
- hsa-mir-4282 (MIRT526515)
- hsa-mir-2681-5p (MIRT639969)
- hsa-mir-4433b-5p (MIRT639970)
- hsa-mir-4693-5p (MIRT639971)
- hsa-mir-4669 (MIRT639972)
- hsa-mir-3657 (MIRT639973)
- hsa-mir-4433a-5p (MIRT639974)
- hsa-mir-4726-3p (MIRT639975)
- hsa-mir-6764-5p (MIRT639976)
- hsa-mir-1915-3p (MIRT639977)
- hsa-mir-6840-3p (MIRT639978)
- hsa-mir-892a (MIRT639979)
- hsa-mir-4318 (MIRT639980)
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POU5F1B Gene
Localization for POU5F1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for POU5F1B Gene
- Nucleus.
- Nucleoplasm (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005739 | mitochondrion | IDA | -- |
GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for POU5F1B Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling pathways regulating pluripotency of stem cells |
Pathways by source for POU5F1B Gene
1 KEGG pathway for POU5F1B Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | NAS | 1408763 |
No data available for SIGNOR curated interactions for POU5F1B Gene
Transcripts for POU5F1B Gene
mRNA/cDNA for POU5F1B Gene
- (1) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (32) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for POU5F1B Gene
CRISPR Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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Expression for POU5F1B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
- NULL (Uncategorized)
NURSA nuclear receptor signaling pathways regulating expression of POU5F1B Gene:
POU5F1BSOURCE GeneReport for Unigene cluster for POU5F1B Gene:
Hs.450254mRNA Expression by UniProt/SwissProt for POU5F1B Gene:
Q06416-P5F1B_HUMANEvidence on tissue expression from TISSUES for POU5F1B Gene
- Liver(4.1)
- Kidney(4)
Primer Products
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No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for POU5F1B Gene
Orthologs for POU5F1B Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | POU5F1B 33 |
|
||
cow (Bos Taurus) |
Mammalia | POU5F1 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany | |||
dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
mouse (Mus musculus) |
Mammalia | Pou5f1 34 |
|
OneToMany | |
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
chicken (Gallus gallus) |
Aves | POUV 34 |
|
OneToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
zebrafish (Danio rerio) |
Actinopterygii | pou5f3 34 |
|
OneToMany | |
fruit fly (Drosophila melanogaster) |
Insecta | acj6 34 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | unc-86 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for POU5F1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for POU5F1B Gene
Paralogs for POU5F1B Gene
(12) SIMAP similar genes for POU5F1B Gene using alignment to 1 proteins:
Variants for POU5F1B Gene
SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1001668645 | -- | 127,415,202(+) | C/T | upstream_transcript_variant | |
rs1002209669 | -- | 127,417,480(+) | G/T | downstream_transcript_variant | |
rs1002261884 | -- | 127,417,703(+) | T/A | downstream_transcript_variant | |
rs1002743416 | -- | 127,414,082(+) | G/C | upstream_transcript_variant | |
rs1003096032 | -- | 127,413,830(+) | C/T | upstream_transcript_variant |
Additional Variant Information for POU5F1B Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU5F1B Gene
Disorders for POU5F1B Gene
Additional Disease Information for POU5F1B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for POU5F1B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POU5F1B Gene
Publications for POU5F1B Gene
- Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. (PMID: 1408763) Takeda J … Bell GI (Nucleic acids research 1992) 2 3 4 58
- Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PMID: 22041458) Clark SL … van den Oord EJ (Psychological medicine 2012) 3 44 58
- The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1. (PMID: 18949397) Panagopoulos I … Mertens F (Oncology reports 2008) 3 4 58
- Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. (PMID: 17401363) Yeager M … Thomas G (Nature genetics 2007) 3 44 58
- Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. (PMID: 17401366) Gudmundsson J … Stefansson K (Nature genetics 2007) 3 44 58
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Sources for POU5F1B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
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