Aliases for POU5F1B Gene
Aliases for POU5F1B Gene
- POU Domain Class 5, Transcription Factor 1 Pseudogene 1 2
- Putative POU Domain, Class 5, Transcription Factor 1B 3
- Octamer-Binding Transcription Factor 3-Like 4
- POU Domain Transcription Factor OCT4-Pg1 3
- Octamer Binding Protein 3_like Sequence 3
- POU Domain Transcription Factor Oct-4 3
- Octamer-Binding Protein 3-Like 4
- POU 5 Domain Protein 3
- POU5F1P4 3
External Ids for POU5F1B Gene
- HGNC: 9223
- Entrez Gene: 5462
- Ensembl: ENSG00000212993
- OMIM: 615739
- UniProtKB: Q06416
Previous HGNC Symbols for POU5F1B Gene
- OTF3P1
- POU5F1P1
Previous GeneCards Identifiers for POU5F1B Gene
- GC08P128499
- GC08P123746
- GC08P128426
Summaries for POU5F1B Gene
-
This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009]
GeneCards Summary for POU5F1B Gene
POU5F1B (POU Class 5 Homeobox 1B) is a Protein Coding gene. Diseases associated with POU5F1B include Prostate Cancer Susceptibility. Among its related pathways are Signaling pathways regulating pluripotency of stem cells. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is POU5F1.
UniProtKB/Swiss-Prot for POU5F1B Gene
-
Shows weak transcriptional activator activity.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU5F1B Gene
Genomics for POU5F1B Gene
Regulatory Elements for POU5F1B Gene
Enhancers for POU5F1B Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH08G127426 | 0.8 | Ensembl ENCODE | 0.4 | +12.8 | 12848 | 1.8 | PKNOX1 NONO ZNF207 CEBPG HES1 | CASC8 POU5F1B |
| GH08G127457 | 0.7 | Ensembl ENCODE | 0.3 | +44.1 | 44075 | 0.9 | SIX4 EHMT2 REST | CASC8 POU5F1B |
| GH08G127477 | 0.9 | Ensembl ENCODE | 0.2 | +64.6 | 64615 | 2.6 | ZGPAT GATA3 JUND SMARCA4 TAF1 JUN FOS EP300 | CASC8 POU5F1B |
| GH08G127451 | 0.5 | FANTOM5 | 0.3 | +37.7 | 37694 | 0.1 | ZNF316 PAX8 MAFK | CASC8 POU5F1B |
| GH08G127480 | 0.6 | Ensembl ENCODE | 0.2 | +66.9 | 66854 | 1.3 | SMARCA4 | CASC8 POU5F1B |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around POU5F1B on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the POU5F1B gene promoter:
Regulatory Element Products
Genomic Location for POU5F1B Gene
- Chromosome:
- 8
- Start:
- 127,414,290 bp from pter
- End:
- 127,420,069 bp from pter
- Size:
- 5,780 bases
- Orientation:
- Plus strand
Genomic View for POU5F1B Gene
Genes around POU5F1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.21 by Ensembl
- 8q24.21 by Entrez Gene
- 8q24.21 by HGNC
POU5F1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POU5F1B Gene
Proteins for POU5F1B Gene
-
Protein details for POU5F1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q06416-P5F1B_HUMAN
- Recommended name:
- Putative POU domain, class 5, transcription factor 1B
- Protein Accession:
- Q06416
- D5K9S4
- D5K9S9
- D5K9T0
- D5K9T1
- D5K9T3
- D5K9U3
- D5K9U6
- D5K9V4
- D5K9V6
- D5K9W0
- D5K9W2
- D5K9W7
- D5K9X2
- D5K9X3
- D5K9X5
- D5K9X8
- D5K9X9
- E9LRB1
- E9LRB2
- E9LRH5
- E9LRH6
- E9LRH7
- E9LRK4
- E9LRK5
- E9LRK7
- E9LRK8
- E9LRM7
- E9LRM9
- E9LRN2
- E9LRN4
- E9LRN5
- E9LRP8
- E9LRQ0
- E9LRQ2
- E9LRQ3
- E9LRQ4
- E9LRQ5
- E9LRS3
- Q2VIK6
- Q9BZV7
- Q9BZV9
Protein attributes for POU5F1B Gene
- Size:
- 359 amino acids
- Molecular mass:
- 38588 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for POU5F1B Gene
Other Protein References for POU5F1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam antibodies for POU5F1B
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- antibodies-online Antibodies for POU5F1B: See all 24
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-
Santa Cruz Biotechnology (SCBT) Antibodies for POU5F1B
Protein Products
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No data available for DME Specific Peptides for POU5F1B Gene
Domains & Families for POU5F1B Gene
Gene Families for POU5F1B Gene
Protein Domains for POU5F1B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for POU5F1B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q06416UniProtKB/Swiss-Prot:
P5F1B_HUMAN :- Belongs to the POU transcription factor family. Class-5 subfamily.
- Family:
-
- Belongs to the POU transcription factor family. Class-5 subfamily.
Function for POU5F1B Gene
Molecular function for POU5F1B Gene
- UniProtKB/Swiss-Prot Function:
- Shows weak transcriptional activator activity.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | TAS | 1408763 |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for POU5F1B Gene
Animal Model Products
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CRISPR Products
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miRNA for POU5F1B Gene
- miRTarBase miRNAs that target POU5F1B
-
- hsa-mir-7853-5p (MIRT526499)
- hsa-mir-105-5p (MIRT526500)
- hsa-mir-8485 (MIRT526501)
- hsa-mir-6848-3p (MIRT526502)
- hsa-mir-6843-3p (MIRT526503)
- hsa-mir-3663-5p (MIRT526504)
- hsa-mir-372-5p (MIRT526505)
- hsa-mir-371a-5p (MIRT526506)
- hsa-mir-616-5p (MIRT526507)
- hsa-mir-373-5p (MIRT526508)
- hsa-mir-371b-5p (MIRT526509)
- hsa-mir-4698 (MIRT526510)
- hsa-mir-8063 (MIRT526511)
- hsa-mir-3163 (MIRT526512)
- hsa-mir-590-3p (MIRT526513)
- hsa-mir-5692a (MIRT526514)
- hsa-mir-4282 (MIRT526515)
- hsa-mir-2681-5p (MIRT639969)
- hsa-mir-4433b-5p (MIRT639970)
- hsa-mir-4693-5p (MIRT639971)
- hsa-mir-4669 (MIRT639972)
- hsa-mir-3657 (MIRT639973)
- hsa-mir-4433a-5p (MIRT639974)
- hsa-mir-4726-3p (MIRT639975)
- hsa-mir-6764-5p (MIRT639976)
- hsa-mir-1915-3p (MIRT639977)
- hsa-mir-6840-3p (MIRT639978)
- hsa-mir-892a (MIRT639979)
- hsa-mir-4318 (MIRT639980)
miRNA Products
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Inhibitory RNA Products
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VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
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Horizon Cell Lines for POU5F1B
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POU5F1B Gene
Localization for POU5F1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for POU5F1B Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| mitochondrion | 4 |
| cytosol | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for POU5F1B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling pathways regulating pluripotency of stem cells | ||
Pathways by source for POU5F1B Gene
1 KEGG pathway for POU5F1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | NAS | 1408763 |
No data available for SIGNOR curated interactions for POU5F1B Gene
Transcripts for POU5F1B Gene
mRNA/cDNA for POU5F1B Gene
- (1) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (32) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for POU5F1B Gene
CRISPR Products
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OriGene CRISPR knockouts for POU5F1B
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Santa Cruz Biotechnology (SCBT) CRISPR for POU5F1B
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miRNA Products
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Inhibitory RNA Products
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ViGene Biosciences ready-to-package AAV shRNAs for POU5F1B gene
Clone Products
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OriGene ORF clones in human for POU5F1B
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for POU5F1B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for POU5F1B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
- NULL (Uncategorized)
NURSA nuclear receptor signaling pathways regulating expression of POU5F1B Gene:
POU5F1BSOURCE GeneReport for Unigene cluster for POU5F1B Gene:
Hs.450254mRNA Expression by UniProt/SwissProt for POU5F1B Gene:
Q06416-P5F1B_HUMAN
Tissue specificity:
Detected at the mRNA level in several cancer tissues (breast, uterine cervix, lung, thyroid gland, esophagus, colon, urinary bladder, and glioma), but absent in normal tissues.
Evidence on tissue expression from TISSUES for POU5F1B Gene
- Liver(4.1)
- Kidney(4)
Primer Products
-
OriGene qPCR primer pairs for POU5F1B
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for POU5F1B Gene
Orthologs for POU5F1B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | POU5F1B 34 |
|
||
| cow (Bos Taurus) |
Mammalia | POU5F1 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Pou5f1 35 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | POUV 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | pou5f3 35 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | acj6 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | unc-86 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for POU5F1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for POU5F1B Gene
Paralogs for POU5F1B Gene
(12) SIMAP similar genes for POU5F1B Gene using alignment to 1 proteins:
Variants for POU5F1B Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1001668645 | -- | 127,415,202(+) | TTAAG(C/T)TATTA | intron-variant, upstream-variant-2KB | |
| rs1002209669 | -- | 127,417,480(+) | ATACA(G/T)ATAAT | intron-variant, downstream-variant-500B | |
| rs1002261884 | -- | 127,417,703(+) | ATAAT(A/T)TTTTT | intron-variant, downstream-variant-500B | |
| rs1002743416 | -- | 127,414,082(+) | GGTTG(C/G)CAGGA | intron-variant, upstream-variant-2KB | |
| rs1003096032 | -- | 127,413,830(+) | AAACA(C/T)ATTTT | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
16.29;
97.65% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for POU5F1B Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU5F1B Gene
Disorders for POU5F1B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| prostate cancer susceptibility |
|
|
Search POU5F1B in MalaCards
View complete list of genes associated with diseases
Relevant External Links for POU5F1B
No data available for UniProtKB/Swiss-Prot and Genatlas for POU5F1B Gene
Publications for POU5F1B Gene
- Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. (PMID: 1408763) Takeda J. … Bell G.I. (Nucleic Acids Res. 1992) 2 3 4 64
- Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. (PMID: 22041458) Clark S.L. … van den Oord E.J. (Psychol Med 2012) 3 46 64
- The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1. (PMID: 18949397) Panagopoulos I. … Mertens F. (Oncol. Rep. 2008) 3 4 64
- Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. (PMID: 17401363) Yeager M. … Thomas G. (Nat. Genet. 2007) 3 46 64
- Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. (PMID: 17401366) Gudmundsson J. … Stefansson K. (Nat. Genet. 2007) 3 46 64
Products for POU5F1B Gene
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- VectorBuilder custom plasmid, inducible vectors for POU5F1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for POU5F1B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for POU5F1B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
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