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Aliases for POU5F1B Gene

Aliases for POU5F1B Gene

  • POU Class 5 Homeobox 1B 2 3 5
  • POU Class 5 Homeobox 1 Pseudogene 1 2 3
  • POU5FLC20 3 4
  • OCT4-PG1 3 4
  • POU5F1P1 3 4
  • POU5FLC8 3 4
  • OCT4PG1 3 4
  • OTF3P1 3 4
  • OTF3C 3 4
  • POU Domain, Class 5, Transcription Factor 1 Pseudogene 1 3
  • POU Domain Class 5, Transcription Factor 1 Pseudogene 1 2
  • Octamer-Binding Transcription Factor 3-Like 4
  • POU Domain Transcription Factor OCT4-Pg1 3
  • Octamer Binding Protein 3_like Sequence 3
  • POU Domain Transcription Factor Oct-4 3
  • Octamer-Binding Protein 3-Like 4
  • POU 5 Domain Protein 3
  • POU5F1P4 3

External Ids for POU5F1B Gene

Previous HGNC Symbols for POU5F1B Gene

  • OTF3P1
  • POU5F1P1

Previous GeneCards Identifiers for POU5F1B Gene

  • GC08P128499
  • GC08P123746
  • GC08P128426

Summaries for POU5F1B Gene

Entrez Gene Summary for POU5F1B Gene

  • This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009]

GeneCards Summary for POU5F1B Gene

POU5F1B (POU Class 5 Homeobox 1B) is a Protein Coding gene. Diseases associated with POU5F1B include Mature Teratoma and Malignant Teratoma. Among its related pathways are Signaling pathways regulating pluripotency of stem cells. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is POU6F1.

UniProtKB/Swiss-Prot for POU5F1B Gene

  • Shows weak transcriptional activator activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU5F1B Gene

Genomics for POU5F1B Gene

Regulatory Elements for POU5F1B Gene

Enhancers for POU5F1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POU5F1B on UCSC Golden Path with GeneCards custom track

Genomic Location for POU5F1B Gene

127,414,290 bp from pter
127,420,069 bp from pter
5,780 bases
Plus strand

Genomic View for POU5F1B Gene

Genes around POU5F1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POU5F1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POU5F1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU5F1B Gene

Proteins for POU5F1B Gene

  • Protein details for POU5F1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative POU domain, class 5, transcription factor 1B
    Protein Accession:
    Secondary Accessions:
    • D5K9S4
    • D5K9S9
    • D5K9T0
    • D5K9T1
    • D5K9T3
    • D5K9U3
    • D5K9U6
    • D5K9V4
    • D5K9V6
    • D5K9W0
    • D5K9W2
    • D5K9W7
    • D5K9X2
    • D5K9X3
    • D5K9X5
    • D5K9X8
    • D5K9X9
    • E9LRB1
    • E9LRB2
    • E9LRH5
    • E9LRH6
    • E9LRH7
    • E9LRK4
    • E9LRK5
    • E9LRK7
    • E9LRK8
    • E9LRM7
    • E9LRM9
    • E9LRN2
    • E9LRN4
    • E9LRN5
    • E9LRP8
    • E9LRQ0
    • E9LRQ2
    • E9LRQ3
    • E9LRQ4
    • E9LRQ5
    • E9LRS3
    • Q2VIK6
    • Q9BZV7
    • Q9BZV9

    Protein attributes for POU5F1B Gene

    359 amino acids
    Molecular mass:
    38588 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POU5F1B Gene

Proteomics data for POU5F1B Gene at MOPED

Post-translational modifications for POU5F1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU5F1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for POU5F1B Gene

Domains & Families for POU5F1B Gene

Gene Families for POU5F1B Gene

Protein Domains for POU5F1B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the POU transcription factor family. Class-5 subfamily.
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 POU-specific domain.
  • Belongs to the POU transcription factor family. Class-5 subfamily.
genes like me logo Genes that share domains with POU5F1B: view

Function for POU5F1B Gene

Molecular function for POU5F1B Gene

UniProtKB/Swiss-Prot Function:
Shows weak transcriptional activator activity.
genes like me logo Genes that share phenotypes with POU5F1B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POU5F1B Gene

Localization for POU5F1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU5F1B Gene

Subcellular locations from

Jensen Localization Image for POU5F1B Gene COMPARTMENTS Subcellular localization image for POU5F1B gene
Compartment Confidence
nucleus 5
cytoskeleton 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for POU5F1B Gene

Pathways & Interactions for POU5F1B Gene

genes like me logo Genes that share pathways with POU5F1B: view

Pathways by source for POU5F1B Gene

Interacting Proteins for POU5F1B Gene

Gene Ontology (GO) - Biological Process for POU5F1B Gene


No data available for SIGNOR curated interactions for POU5F1B Gene

Drugs & Compounds for POU5F1B Gene

No Compound Related Data Available

Transcripts for POU5F1B Gene

mRNA/cDNA for POU5F1B Gene

(1) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POU5F1B Gene

POU class 5 homeobox 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POU5F1B Gene

No ASD Table

Relevant External Links for POU5F1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for POU5F1B Gene

mRNA expression in normal human tissues for POU5F1B Gene

SOURCE GeneReport for Unigene cluster for POU5F1B Gene Hs.450254

mRNA Expression by UniProt/SwissProt for POU5F1B Gene

Tissue specificity: Detected at the mRNA level in several cancer tissues (breast, uterine cervix, lung, thyroid gland, esophagus, colon, urinary bladder, and glioma), but absent in normal tissues.
genes like me logo Genes that share expression patterns with POU5F1B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for POU5F1B Gene

Orthologs for POU5F1B Gene

This gene was present in the common ancestor of animals.

Orthologs for POU5F1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia POU5F1B 35
  • 97.96 (n)
  • 96.1 (a)
(Bos Taurus)
Mammalia -- 36
  • 67 (a)
POU5F1 36
  • 89 (a)
(Canis familiaris)
Mammalia -- 36
  • 88 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
(Mus musculus)
Mammalia Pou5f1 36
  • 83 (a)
(Gallus gallus)
Aves POUV 36
  • 39 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
(Danio rerio)
Actinopterygii pou5f3 36
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta acj6 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea unc-86 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
Species with no ortholog for POU5F1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for POU5F1B Gene

Gene Tree for POU5F1B (if available)
Gene Tree for POU5F1B (if available)

Paralogs for POU5F1B Gene

(12) SIMAP similar genes for POU5F1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POU5F1B: view

Variants for POU5F1B Gene

Sequence variations from dbSNP and Humsavar for POU5F1B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_067432 -
VAR_067433 -
VAR_067434 -
VAR_067435 -
VAR_067436 -

Structural Variations from Database of Genomic Variants (DGV) for POU5F1B Gene

Variant ID Type Subtype PubMed ID
nsv7419 OTHER Inversion 18451855
nsv499795 OTHER Inversion 21111241

Variation tolerance for POU5F1B Gene

Residual Variation Intolerance Score: 94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.29; 97.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POU5F1B Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU5F1B Gene

Disorders for POU5F1B Gene

MalaCards: The human disease database

(4) MalaCards diseases for POU5F1B Gene - From: DISEASES

Disorder Aliases PubMed IDs
mature teratoma
  • dermoid cyst
malignant teratoma
  • immature teratoma
ovarian germ cell teratoma
  • germ cell teratoma of ovary
  • hidradenoma morphology
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for POU5F1B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with POU5F1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for POU5F1B Gene

Publications for POU5F1B Gene

  1. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. (PMID: 1408763) Takeda J. … Bell G.I. (Nucleic Acids Res. 1992) 2 3 4 67
  2. A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. (PMID: 24292274) Speedy H.E. … Houlston R.S. (Nat. Genet. 2014) 3
  3. Expression and differentiation between OCT4A and its Pseudogenes in human ESCs and differentiated adult somatic cells. (PMID: 24586860) Jez M. … Dominko T. (PLoS ONE 2014) 3
  4. Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies. (PMID: 24753544) Knipe D.W. … Martin R.M. (Cancer Epidemiol. Biomarkers Prev. 2014) 3
  5. Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer. (PMID: 24861552) Rafnar T. … Stefansson K. (Hum. Mol. Genet. 2014) 3

Products for POU5F1B Gene

Sources for POU5F1B Gene