Aliases for POU5F1B Gene
Aliases for POU5F1B Gene
External Ids for POU5F1B Gene
- HGNC: 9223
- Entrez Gene: 5462
- Ensembl: ENSG00000212993
- OMIM: 615739
- UniProtKB: Q06416
Previous HGNC Symbols for POU5F1B Gene
- OTF3P1
- POU5F1P1
Previous GeneCards Identifiers for POU5F1B Gene
- GC08P128499
- GC08P123746
- GC08P128426
Summaries for POU5F1B Gene
-
This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009]
GeneCards Summary for POU5F1B Gene
POU5F1B (POU Class 5 Homeobox 1B) is a Protein Coding gene. Diseases associated with POU5F1B include Mature Teratoma and Malignant Teratoma. Among its related pathways are Signaling pathways regulating pluripotency of stem cells. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is POU6F1.
UniProtKB/Swiss-Prot for POU5F1B Gene
-
Shows weak transcriptional activator activity.
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU5F1B Gene
Genomics for POU5F1B Gene
Regulatory Elements for POU5F1B Gene
Enhancers for POU5F1B Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around POU5F1B on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the POU5F1B gene promoter:
Regulatory Element Products
Genomic Location for POU5F1B Gene
- Chromosome:
- 8
- Start:
- 127,414,290 bp from pter
- End:
- 127,420,069 bp from pter
- Size:
- 5,780 bases
- Orientation:
- Plus strand
Genomic View for POU5F1B Gene
Genes around POU5F1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.21 by Ensembl
- 8q24.21 by Entrez Gene
- 8q24.21 by HGNC
POU5F1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for POU5F1B Gene
Proteins for POU5F1B Gene
-
Protein details for POU5F1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q06416-P5F1B_HUMAN
- Recommended name:
- Putative POU domain, class 5, transcription factor 1B
- Protein Accession:
- Q06416
- D5K9S4
- D5K9S9
- D5K9T0
- D5K9T1
- D5K9T3
- D5K9U3
- D5K9U6
- D5K9V4
- D5K9V6
- D5K9W0
- D5K9W2
- D5K9W7
- D5K9X2
- D5K9X3
- D5K9X5
- D5K9X8
- D5K9X9
- E9LRB1
- E9LRB2
- E9LRH5
- E9LRH6
- E9LRH7
- E9LRK4
- E9LRK5
- E9LRK7
- E9LRK8
- E9LRM7
- E9LRM9
- E9LRN2
- E9LRN4
- E9LRN5
- E9LRP8
- E9LRQ0
- E9LRQ2
- E9LRQ3
- E9LRQ4
- E9LRQ5
- E9LRS3
- Q2VIK6
- Q9BZV7
- Q9BZV9
Protein attributes for POU5F1B Gene
- Size:
- 359 amino acids
- Molecular mass:
- 38588 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for POU5F1B Gene
Other Protein References for POU5F1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for POU5F1B
- Novus Biologicals Antibodies for POU5F1B
- Abcam antibodies for POU5F1B
- Invitrogen Antibodies for POU5F1B
- antibodies-online Antibodies for POU5F1B: See all 24
- Search GeneTex for Antibodies for POU5F1B
-
Santa Cruz Biotechnology (SCBT) Antibodies for POU5F1B
Protein Products
-
OriGene Purified Proteins for POU5F1B
- Search Origene for MassSpec and Protein Over-expression Lysates for POU5F1B
- Origene Custom Protein Services for POU5F1B
- Novus Biologicals proteins for POU5F1B
- Search GeneTex for Proteins for POU5F1B
Assay Products
No data available for DME Specific Peptides for POU5F1B Gene
Domains & Families for POU5F1B Gene
Gene Families for POU5F1B Gene
Protein Domains for POU5F1B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for POU5F1B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q06416UniProtKB/Swiss-Prot:
P5F1B_HUMAN :- Contains 1 homeobox DNA-binding domain.
- Belongs to the POU transcription factor family. Class-5 subfamily.
- Domain:
-
- Contains 1 homeobox DNA-binding domain.
- Contains 1 POU-specific domain.
- Family:
-
- Belongs to the POU transcription factor family. Class-5 subfamily.
Function for POU5F1B Gene
Molecular function for POU5F1B Gene
- UniProtKB/Swiss-Prot Function:
- Shows weak transcriptional activator activity.
Phenotypes for POU5F1B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for POU5F1B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for POU5F1B gene
- Search ViGene Biosciences for POU5F1B
CRISPR Products
-
OriGene CRISPR knockouts for POU5F1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for POU5F1B
- GenScript: Design CRISPR guide RNA sequences for POU5F1B
miRNA for POU5F1B Gene
- miRTarBase miRNAs that target POU5F1B
-
- hsa-mir-7853-5p (MIRT526499)
- hsa-mir-105-5p (MIRT526500)
- hsa-mir-8485 (MIRT526501)
- hsa-mir-6848-3p (MIRT526502)
- hsa-mir-6843-3p (MIRT526503)
- hsa-mir-3663-5p (MIRT526504)
- hsa-mir-372-5p (MIRT526505)
- hsa-mir-371a-5p (MIRT526506)
- hsa-mir-616-5p (MIRT526507)
- hsa-mir-373-5p (MIRT526508)
- hsa-mir-371b-5p (MIRT526509)
- hsa-mir-4698 (MIRT526510)
- hsa-mir-8063 (MIRT526511)
- hsa-mir-3163 (MIRT526512)
- hsa-mir-590-3p (MIRT526513)
- hsa-mir-5692a (MIRT526514)
- hsa-mir-4282 (MIRT526515)
- hsa-mir-2681-5p (MIRT639969)
- hsa-mir-4433b-5p (MIRT639970)
- hsa-mir-4693-5p (MIRT639971)
- hsa-mir-4669 (MIRT639972)
- hsa-mir-3657 (MIRT639973)
- hsa-mir-4433a-5p (MIRT639974)
- hsa-mir-4726-3p (MIRT639975)
- hsa-mir-6764-5p (MIRT639976)
- hsa-mir-1915-3p (MIRT639977)
- hsa-mir-6840-3p (MIRT639978)
- hsa-mir-892a (MIRT639979)
- hsa-mir-4318 (MIRT639980)
miRNA Products
- Search ViGene Biosciences for POU5F1B
Inhibitory RNA Products
- Origene siRNA and RNAi products in human, mouse, rat for POU5F1B
- Browse OriGene Inhibitory RNA Products For POU5F1B
-
ViGene Biosciences ready-to-package AAV shRNAs for POU5F1B gene
Clone Products
- OriGene clones in human for POU5F1B
- OriGene ORF clones in human for POU5F1B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for POU5F1B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for POU5F1B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for POU5F1B gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POU5F1B Gene
Localization for POU5F1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for POU5F1B Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 1 |
| extracellular | 1 |
No data available for Gene Ontology (GO) - Cellular Components for POU5F1B Gene
Pathways & Interactions for POU5F1B Gene
More details on SuperPathways for POU5F1B| Superpath | Contained pathways | |
|---|---|---|
| 1 | Signaling pathways regulating pluripotency of stem cells |
Pathways by source for POU5F1B Gene
1 KEGG pathway for POU5F1B Gene
Interacting Proteins for POU5F1B Gene
No data available for SIGNOR curated interactions for POU5F1B Gene
Transcripts for POU5F1B Gene
mRNA/cDNA for POU5F1B Gene
- (1) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (32) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for POU5F1B Gene
CRISPR Products
-
OriGene CRISPR knockouts for POU5F1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for POU5F1B
- GenScript: Design CRISPR guide RNA sequences for POU5F1B
miRNA Products
- Search ViGene Biosciences for POU5F1B
Inhibitory RNA Products
- Origene siRNA and RNAi products in human, mouse, rat for POU5F1B
- Browse OriGene Inhibitory RNA Products For POU5F1B
-
ViGene Biosciences ready-to-package AAV shRNAs for POU5F1B gene
Clone Products
- OriGene clones in human for POU5F1B
- OriGene ORF clones in human for POU5F1B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Flow Cytometry Products
Expression for POU5F1B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
- NULL (Uncategorized)
SOURCE GeneReport for Unigene cluster for POU5F1B Gene Hs.450254
mRNA Expression by UniProt/SwissProt for POU5F1B Gene
Q06416-P5F1B_HUMAN
Tissue specificity:
Detected at the mRNA level in several cancer tissues (breast, uterine cervix, lung, thyroid gland, esophagus, colon, urinary bladder, and glioma), but absent in normal tissues.
Primer Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for POU5F1B Gene
Orthologs for POU5F1B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | POU5F1B 35 |
|
||
| cow (Bos Taurus) |
Mammalia | -- 36 |
|
ManyToMany | |
| POU5F1 36 |
|
ManyToMany | |||
| dog (Canis familiaris) |
Mammalia | -- 36 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Pou5f1 36 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | POUV 36 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 36 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | pou5f3 36 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | acj6 36 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | unc-86 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany |
- Species with no ortholog for POU5F1B:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for POU5F1B Gene
Paralogs for POU5F1B Gene
(12) SIMAP similar genes for POU5F1B Gene using alignment to 1 proteins:
Variants for POU5F1B Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_067432 | - | ||||
| VAR_067433 | - | ||||
| VAR_067434 | - | ||||
| VAR_067435 | - | ||||
| VAR_067436 | - |
Residual Variation Intolerance Score:
94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
16.29;
97.65% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for POU5F1B Gene
- Human Gene Mutation Database (HGMD)
- POU5F1B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU5F1B Gene
Disorders for POU5F1B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mature teratoma |
|
|
| malignant teratoma |
|
|
| ovarian germ cell teratoma |
|
|
| hidradenoma |
|
|
Search POU5F1B in MalaCards
View complete list of genes associated with diseases
Relevant External Links for POU5F1B
No data available for UniProtKB/Swiss-Prot and Genatlas for POU5F1B Gene
Publications for POU5F1B Gene
- Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. (PMID: 1408763) Takeda J. … Bell G.I. (Nucleic Acids Res. 1992) 2 3 4 67
- A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. (PMID: 24292274) Speedy H.E. … Houlston R.S. (Nat. Genet. 2014) 3
- Expression and differentiation between OCT4A and its Pseudogenes in human ESCs and differentiated adult somatic cells. (PMID: 24586860) Jez M. … Dominko T. (PLoS ONE 2014) 3
- Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies. (PMID: 24753544) Knipe D.W. … Martin R.M. (Cancer Epidemiol. Biomarkers Prev. 2014) 3
- Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer. (PMID: 24861552) Rafnar T. … Stefansson K. (Hum. Mol. Genet. 2014) 3
Products for POU5F1B Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for POU5F1B
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for POU5F1B
- Search Origene for MassSpec and Protein Over-expression Lysates for POU5F1B
- Origene Custom Protein Services for POU5F1B
- Origene siRNA and RNAi products in human, mouse, rat for POU5F1B
- Browse OriGene Inhibitory RNA Products For POU5F1B
- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for POU5F1B
- OriGene clones in human for POU5F1B
- OriGene ORF clones in human for POU5F1B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for POU5F1B
- GenScript Custom Assay Services for POU5F1B
- GenScript Custom overexpressing Cell Line Services for POU5F1B
- GenScript: Design CRISPR guide RNA sequences for POU5F1B
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for POU5F1B
- Novus Biologicals Antibodies for POU5F1B
- Novus Biologicals proteins for POU5F1B
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for POU5F1B
- ViGene Biosciences adenoviral particle packaged cDNA for POU5F1B gene
- ViGene Biosciences lentiviral particle packaged cDNA for POU5F1B gene
- ViGene Biosciences lentiviral particle packaged cDNA for POU5F1B gene
- ViGene Biosciences ready-to-package AAV shRNAs for POU5F1B gene
- ViGene Biosciences ready-to-package AAV shRNAs for POU5F1B gene
- ViGene Biosciences ready-to-package AAV shRNAs for POU5F1B gene
- Search ViGene Biosciences for POU5F1B
- Search ViGene Biosciences for POU5F1B
- Santa Cruz Biotechnology (SCBT) Antibodies for POU5F1B
- Search Santa Cruz Biotechnology (SCBT) for POU5F1B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for POU5F1B
Sources for POU5F1B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon