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Aliases for POU5F1B Gene

Aliases for POU5F1B Gene

  • POU Class 5 Homeobox 1B 2 3
  • POU Class 5 Homeobox 1 Pseudogene 1 2 3
  • POU5FLC20 3 4
  • OCT4-PG1 3 4
  • POU5F1P1 3 4
  • POU5FLC8 3 4
  • OCT4PG1 3 4
  • OTF3P1 3 4
  • OTF3C 3 4
  • POU Domain, Class 5, Transcription Factor 1 Pseudogene 1 3
  • POU Domain Class 5, Transcription Factor 1 Pseudogene 1 2
  • Putative POU Domain, Class 5, Transcription Factor 1B 3
  • Octamer-Binding Transcription Factor 3-Like 4
  • POU Domain Transcription Factor OCT4-Pg1 3
  • Octamer Binding Protein 3_like Sequence 3
  • POU Domain Transcription Factor Oct-4 3
  • Octamer-Binding Protein 3-Like 4
  • POU 5 Domain Protein 3
  • POU5F1P4 3

External Ids for POU5F1B Gene

Previous HGNC Symbols for POU5F1B Gene

  • OTF3P1
  • POU5F1P1

Previous GeneCards Identifiers for POU5F1B Gene

  • GC08P128499
  • GC08P123746
  • GC08P128426

Summaries for POU5F1B Gene

Entrez Gene Summary for POU5F1B Gene

  • This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009]

GeneCards Summary for POU5F1B Gene

POU5F1B (POU Class 5 Homeobox 1B) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is POU6F1.

UniProtKB/Swiss-Prot for POU5F1B Gene

  • Shows weak transcriptional activator activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POU5F1B Gene

Genomics for POU5F1B Gene

Regulatory Elements for POU5F1B Gene

Genomic Location for POU5F1B Gene

Start:
127,414,290 bp from pter
End:
127,420,069 bp from pter
Size:
5,780 bases
Orientation:
Plus strand

Genomic View for POU5F1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POU5F1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POU5F1B Gene

Proteins for POU5F1B Gene

  • Protein details for POU5F1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06416-P5F1B_HUMAN
    Recommended name:
    Putative POU domain, class 5, transcription factor 1B
    Protein Accession:
    Q06416
    Secondary Accessions:
    • D5K9S4
    • D5K9S9
    • D5K9T0
    • D5K9T1
    • D5K9T3
    • D5K9U3
    • D5K9U6
    • D5K9V4
    • D5K9V6
    • D5K9W0
    • D5K9W2
    • D5K9W7
    • D5K9X2
    • D5K9X3
    • D5K9X5
    • D5K9X8
    • D5K9X9
    • E9LRB1
    • E9LRB2
    • E9LRH5
    • E9LRH6
    • E9LRH7
    • E9LRK4
    • E9LRK5
    • E9LRK7
    • E9LRK8
    • E9LRM7
    • E9LRM9
    • E9LRN2
    • E9LRN4
    • E9LRN5
    • E9LRP8
    • E9LRQ0
    • E9LRQ2
    • E9LRQ3
    • E9LRQ4
    • E9LRQ5
    • E9LRS3
    • Q2VIK6
    • Q9BZV7
    • Q9BZV9

    Protein attributes for POU5F1B Gene

    Size:
    359 amino acids
    Molecular mass:
    38588 Da
    Quaternary structure:
    No Data Available

neXtProt entry for POU5F1B Gene

Proteomics data for POU5F1B Gene at MOPED

Post-translational modifications for POU5F1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for POU5F1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for POU5F1B Gene

Domains for POU5F1B Gene

Gene Families for POU5F1B Gene

HGNC:
  • POU :Homeoboxes / POU class

Protein Domains for POU5F1B Gene

Suggested Antigen Peptide Sequences for POU5F1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q06416

UniProtKB/Swiss-Prot:

P5F1B_HUMAN :
  • Q06416
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 POU-specific domain.
Family:
  • Belongs to the POU transcription factor family. Class-5 subfamily.
genes like me logo Genes that share domains with POU5F1B: view

Function for POU5F1B Gene

Molecular function for POU5F1B Gene

UniProtKB/Swiss-Prot Function:
Shows weak transcriptional activator activity.

Gene Ontology (GO) - Molecular Function for POU5F1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 1408763
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with POU5F1B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for POU5F1B Gene

Localization for POU5F1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for POU5F1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POU5F1B Gene COMPARTMENTS Subcellular localization image for POU5F1B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for POU5F1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with POU5F1B: view

Pathways for POU5F1B Gene

SuperPathways for POU5F1B Gene

No Data Available

Interacting Proteins for POU5F1B Gene

Gene Ontology (GO) - Biological Process for POU5F1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 1408763
genes like me logo Genes that share ontologies with POU5F1B: view

No data available for Pathways by source for POU5F1B Gene

Transcripts for POU5F1B Gene

mRNA/cDNA for POU5F1B Gene

(32) Selected AceView cDNA sequences:
(17) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for POU5F1B Gene

POU class 5 homeobox 1B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POU5F1B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POU5F1B Gene

No ASD Table

Relevant External Links for POU5F1B Gene

GeneLoc Exon Structure for
POU5F1B
ECgene alternative splicing isoforms for
POU5F1B

Expression for POU5F1B Gene

mRNA expression in normal human tissues for POU5F1B Gene

SOURCE GeneReport for Unigene cluster for POU5F1B Gene Hs.450254

mRNA Expression by UniProt/SwissProt for POU5F1B Gene

Q06416-P5F1B_HUMAN
Tissue specificity: Detected at the mRNA level in several cancer tissues (breast, uterine cervix, lung, thyroid gland, esophagus, colon, urinary bladder, and glioma), but absent in normal tissues.
genes like me logo Genes that share expressions with POU5F1B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for POU5F1B Gene

Orthologs for POU5F1B Gene

This gene was present in the common ancestor of animals.

Orthologs for POU5F1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POU5F1B 35
  • 97.96 (n)
  • 96.1 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 67 (a)
ManyToMany
POU5F1 36
  • 89 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 88 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pou5f1 36
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves POUV 36
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii pou5f3 36
  • 28 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta acj6 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-86 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for POU5F1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for POU5F1B Gene

ENSEMBL:
Gene Tree for POU5F1B (if available)
TreeFam:
Gene Tree for POU5F1B (if available)

Paralogs for POU5F1B Gene

Selected SIMAP similar genes for POU5F1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with POU5F1B: view

Variants for POU5F1B Gene

Sequence variations from dbSNP and Humsavar for POU5F1B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
VAR_067432 -
VAR_067433 -
VAR_067434 -
VAR_067435 -
VAR_067436 -

Structural Variations from Database of Genomic Variants (DGV) for POU5F1B Gene

Variant ID Type Subtype PubMed ID
nsv7419 OTHER Inversion 18451855
nsv499795 OTHER Inversion 21111241

Relevant External Links for POU5F1B Gene

HapMap Linkage Disequilibrium report
POU5F1B
Human Gene Mutation Database (HGMD)
POU5F1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POU5F1B Gene

Disorders for POU5F1B Gene

(1) University of Copenhagen DISEASES for POU5F1B Gene

Relevant External Links for POU5F1B

Genetic Association Database (GAD)
POU5F1B
Human Genome Epidemiology (HuGE) Navigator
POU5F1B
genes like me logo Genes that share disorders with POU5F1B: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for POU5F1B Gene

Publications for POU5F1B Gene

  1. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. (PMID: 1408763) Takeda J. … Bell G.I. (Nucleic Acids Res. 1992) 2 3 4
  2. The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1. (PMID: 18949397) Panagopoulos I. … Mertens F. (Oncol. Rep. 2008) 3 4
  3. Emergence of young human genes after a burst of retroposition in primates. (PMID: 16201836) Marques A.C. … Kaessmann H. (PLoS Biol. 2005) 3 4
  4. Oct4 pseudogenes are transcribed in cancers. (PMID: 16229821) Suo G. … Dai J. (Biochem. Biophys. Res. Commun. 2005) 3 4
  5. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. (PMID: 17401363) Yeager M. … Thomas G. (Nat. Genet. 2007) 3 48

Products for POU5F1B Gene

Sources for POU5F1B Gene

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