Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU5F1B Gene

protein-coding   GIFtS: 40
GCID: GC08P128426

POU class 5 homeobox 1B

(Previous names: POU domain class 5, transcription factor 1 pseudogene 1,...)
(Previous symbols: OTF3P1, POU5F1P1)
 Explore 13 diseases affiliated with
POU5F1B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for POU5F1B    

Aliases
for POU5F1B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
POU Class 5 Homeobox 1B1 2     POU5F1P42
OTF3C1 2 3     Octamer Binding Protein 3_like Sequence2
OTF3P11 2 3     POU 5 Domain Protein2
POU5F1P11 2 3     POU Domain Transcription Factor Oct-42
POU Class 5 Homeobox 1 Pseudogene 11 2     POU Domain Transcription Factor OCT4-Pg12
POU5FLC202 3     POU Domain, Class 5, Transcription Factor 1 Pseudogene 12
POU5FLC82 3     Putative POU Domain, Class 5, Transcription Factor 1B2
POU Domain Class 5, Transcription Factor 1 Pseudogene 11     Octamer-Binding Protein 3-Like3
OCT4-PG12     Octamer-Binding Transcription Factor 3-Like3

External Ids:    HGNC: 92231   Entrez Gene: 54622   Ensembl: ENSG000002129937   UniProtKB: Q064163   

Export aliases for POU5F1B gene to outside databases

Previous GC identifers: GC08P128499 GC08P123746


Summaries
for POU5F1B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for POU5F1B:
This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been
reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly
similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and
may play a role in carcinogenesis and eye development. (provided by RefSeq, Apr 2009)

UniProtKB/Swiss-Prot: P5F1B_HUMAN, Q06416
Function: Shows weak transcriptional activator activity




Genomic Views
for POU5F1B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU5F1B gene promoter:
         STAT5B   AML1a   Pbx1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   CUTL1   Cdc5   POU3F2   Gfi-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for POU5F1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU5F1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.21   Ensembl cytogenetic band:  8q24.21   HGNC cytogenetic band: 8q24.21

POU5F1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU5F1B gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P128426:  view genomic region     (about GC identifiers)

Start:
 128,426,535 bp from pter      End:
 128,432,311 bp from pter
Size:
 5,777 bases      Orientation:
 plus strand

Proteins
for POU5F1B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: P5F1B_HUMAN, Q06416 (See protein sequence)
Recommended Name: Putative POU domain, class 5, transcription factor 1B  
Size: 359 amino acids; 38588 Da
Subcellular location: Nucleus
Caution: Could be the product of a pseudogene. Several pseudogenes of POU5F1 have been described on chromosomes 1, 3,
8, 10 and 12. Two of them, localized on chromosomes 8 and 10 have been shown to be preferentially transcribed in
cancer tissues and may be involved in the regulation of POU5F1 gene activity in carcinogenesis
Secondary accessions: D5K9V4 Q2VIK6 Q9BZV7 Q9BZV9

Explore the universe of human proteins at neXtProt for POU5F1B: NX_Q06416

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q06416

    • POU5F1B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001153014.1  
    ENSEMBL proteins: 
     ENSP00000419298   ENSP00000375557  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: POU5F1B
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for POU5F1B 
    GenScript Custom Purified and Recombinant Proteins Services for POU5F1B
    Novus Biologicals POU5F1B Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS--


    POU5F1B for ontologies           About GeneDecksing



    POU5F1B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for POU5F1B 
    GenScript Custom Superior Antibodies Services for POU5F1B
    Novus Biologicals POU5F1B Antibody
    Search for Antibodies for POU5F1B at Abcam  
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for POU5F1B

    Assay Products for POU5F1B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for POU5F1B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for POU5F1B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    POU5F1B for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry Q06416

    ProtoNet protein and cluster: Q06416

    2 Blocks protein families:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: P5F1B_HUMAN, Q06416
    Similarity: Belongs to the POU transcription factor family. Class-5 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    Function
    for POU5F1B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: P5F1B_HUMAN, Q06416
    Function: Shows weak transcriptional activator activity

    miRNA
    Products:            		 OriGene 3'-UTR Clone: POU5F1B
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU5F1B
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate POU5F1B
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene 29mer shRNA kits
    OriGene siRNA: POU5F1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU5F1B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for POU5F1B

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POU5F1B
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POU5F1B
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: POU5F1B (NM_001159542)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU5F1B
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat POU5F1B 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for POU5F1B
    Search LifeMap BioReagents cell lines for POU5F1B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU5F1B

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS1408763
    GO:0043565sequence-specific DNA binding IEA--


    POU5F1B for ontologies           About GeneDecksing



    Pathways & Interactions
    for POU5F1B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for POU5F1B

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS1408763


    POU5F1B for ontologies           About GeneDecksing



    Drugs & Compounds
    for POU5F1B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for POU5F1B
    Search CenterWatch for drugs/clinical trials and news about POU5F1B / P5F1B 

    Transcripts
    for POU5F1B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for POU5F1B gene: 
    NM_001159542.1  

    Unigene Cluster for POU5F1B:

    POU class 5 homeobox 1B
    Hs.450254  [show with all ESTs]
    Unigene Representative Sequence: DQ486513
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465342 ENST00000391675(uc003ysf.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: POU5F1B
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU5F1B
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate POU5F1B
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene 29mer shRNA kits
    OriGene siRNA: POU5F1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU5F1B
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POU5F1B
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POU5F1B
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: POU5F1B (NM_001159542)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU5F1B
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat POU5F1B 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POU5F1B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat POU5F1B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU5F1B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU5F1B

    Additional cDNA sequence: 

    AF268615.1 AF268618.1 DQ486513.1 FM177969.1 FM177970.1 FM177971.1 FM177972.1 FM177973.1 
    FM177974.1 FM177975.1 FM177976.1 FM177977.1 FM177978.1 FM177979.1 FM177980.1 FM177981.1 
    FM177982.1 

    2 DOTS entries:

    DT.100791937  DT.75142423 

    32 AceView cDNA sequences (see top 24):

    AF268615 BM796771 AF268618 BX108223 BM817496 CB144537 BV207915 BV207913 
    BV199595 BV207917 BV207916 BV199596 CD049748 AA196616 CD247012 BM830060 
    AA232432 AA480280 CD048739 BM857157 BV199667 BG656494 CD049560 AA216743 
    BM854645 AA515288 AA515307 AA534908 BG656183 CD048549 AI811039 AA480263 

    GeneLoc Exon Structure


    Expression
    for POU5F1B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU5F1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    POU5F1B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)
    Mesendoderm-like cells (Generation of mesend...)
    Matrigel embedded cells (Derivation of cardio...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See POU5F1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POU5F1B

    SOURCE GeneReport for Unigene cluster: Hs.450254
        SABiosciences Custom PCR Arrays for POU5F1B
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POU5F1B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat POU5F1B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU5F1B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU5F1B
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU5F1B

    Orthologs
    for POU5F1B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for POU5F1B gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 54(a)
    		 1 → many
    		 GL343623.1(305954-310934)
    zebrafish
    (Danio rerio)    		 Actinopterygii pou5f16
    		 POU domain, class 5, transcription factor 1
    		 25(a)
    		 1 → many
    		 21(11887950-11892809)


    ENSEMBL Gene Tree for POU5F1B (if available)
    TreeFam Gene Tree for POU5F1B (if available) 

    Paralogs
    for POU5F1B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POU5F1B gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F42  POU3F12  POU1F12  POU4F32  
    POU3F32  POU3F22  POU2F22  POU2F12  POU4F12  POU5F12  POU6F12  
    13 SIMAP similar genes for POU5F1B using alignment to 1 protein entry:     P5F1B_HUMAN:
    POU5F1P1    POU5F1    POU5F1P3    POU5F1P4    POU6F1    POU3F4
    POU5F2    POU1F1    POU2F2    POU2F1    POU3F2    POU3F1
    POU2F3

    POU5F1B for paralogs           About GeneDecksing



    Genomic Variants
    for POU5F1B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/105 NCBI SNPs in POU5F1B are shown (see all 105)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs796112401,2
    		C,--128425906(+) AAGCAG/AAGCAT 1 -- us2k11Minor allele frequency- A:0.01MN 156
    rs1419396211,2
    		--128425919(+) CCTCAA/GACGAT 1 -- us2k10--------
    rs800553061,2
    		F,--128426003(+) ACTTTT/ACTGCT 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs2017539801,2
    		--128426100(+) AGGTG-/GTGTACA 1 -- us2k10--------
    rs1488252941,2
    		C,--128426102(+) GTGGT-/ACAC  
                ACACA     		1 -- us2k10--------
    rs751701461,2
    		C,--128426103(+) GTGGTA/GCACAC 1 -- us2k10--------
    rs780982571,2
    		C,F,--128426196(+) GAAGTT/GAATGA 1 -- us2k12Minor allele frequency- G:0.05MN NA 246
    rs1507041771,2
    		--128426369(+) TATCTA/GTCTTA 1 -- us2k10--------
    rs8711351,2
    		C,F,A,H,--128426393(+) AGAACT/GTCAAA 1 -- us2k118Minor allele frequency- G:0.43NS EA NA WA MN CSA 1190
    rs1842002931,2
    		--128426433(+) GAGAAC/TGTTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for POU5F1B (128426535 - 128432311 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for POU5F1B
         1 Inversion: 37296
    Human Gene Mutation Database (HGMD): POU5F1B

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POU5F1B
    DNA2.0 Custom Variant and Variant Library Synthesis for POU5F1B

    Disorders / Diseases
    for POU5F1B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    POU5F1B for disorders           About GeneDecksing

    13 diseases for POU5F1B:    About MalaCards
    gonadoblastoma    chronic lymphocytic leukemia    lymphocytic leukemia    teratoma
    embryonal carcinoma    colorectal cancer    prostate carcinoma    leukemia
    prostatitis    prostate cancer    carcinoma    neuronitis
    colorectal cancer 8

    1 disease from the University of Copenhagen DISEASES database for POU5F1B:
    Teratoma
    Human Genome Epidemiology (HuGE) Navigator: POU5F1B (1 document)

    Export disorders for POU5F1B gene to outside databases

    Publications
    for POU5F1B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU5F1B gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with POU5F1B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. (PubMed id 1408763)1, 2, 3 Takeda J.... Bell G.I. (1992)
    2. The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1. (PubMed id 18949397)1, 2 Panagopoulos I....Mertens F. (2008)
    3. Emergence of young human genes after a burst of retroposition in primates. (PubMed id 16201836)1, 2 Marques A.C.... Kaessmann H. (2005)
    4. Pharmacogenomic study of side-effects for antidepressa nt treatment options in STAR*D. (PubMed id 22041458)1 Clark S.L....van den Oord E.J. (2012)
    5. POU5F1P1, a putative cancer susceptibility gene, is o verexpressed in prostatic carcinoma. (PubMed id 20017164)1 Kastler S....Assum G. (2010)
    6. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24 .1 influence chronic lymphocytic leukemia risk. (PubMed id 20062064)1 Crowther-Swanepoel D....Houlston R.S. (2010)
    7. Variation at 8q24 and 9p24 and risk of epithelial ova rian cancer. (PubMed id 20158306)1 White K.L....Goode E.L. (2010)
    8. Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry. (PubMed id 19562729)1 Pal P....Deka R. (2009)
    9. [Identification of the OCT4-pg1 retrogene and NANOG gene expression in the human embryonic eye] (PubMed id 18946985)1 Firsova N.V....Mitashov V.I. (2008)
    10. Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. (PubMed id 18372901)1 Tenesa A....Dunlop M.G. (2008)

    External Searches for POU5F1B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing POU5F1B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5462 HGNC: 9223 AceView: POU5F1P1 Ensembl:ENSG00000212993 euGenes: HUgn5462
    ECgene: POU5F1B H-InvDB: POU5F1B

    Other Databases showing POU5F1B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing POU5F1B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POU5F1B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for POU5F1B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for POU5F1B gene:
    Search GeneIP for patents involving POU5F1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for POU5F1B gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   Browse OriGene shRNA RFPs  
     Browse OriGene 29mer shRNA kits in GFP-retroviral vector   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for POU5F1B  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for POU5F1B   OriGene 3'-UTR Clone for POU5F1B  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POU5F1B   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POU5F1B  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for POU5F1B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for POU5F1B   OriGene Custom Protein Services for POU5F1B  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat POU5F1B
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing POU5F1B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU5F1B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU5F1B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU5F1B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU5F1B
     GenScript Custom Purified and Recombinant Proteins Services for POU5F1B GenScript cDNA clones with any tag delivered in your preferred vector for POU5F1B
     GenScript Custom Assay Services for POU5F1B GenScript Custom Superior Antibodies Services for POU5F1B
     GenScript Custom overexpressing Cell Line Services for POU5F1B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in POU5F1B promoter
     Search Chromatin IP Primers for POU5F1B
     RT2 qPCR Primer Assay in human, mouse / rat POU5F1B
     Search GNC Networks for POU5F1B
     SABiosciences Custom PCR Arrays for POU5F1B
     Search Tocris compounds for POU5F1B
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     POU5F1B antibodies
     POU5F1B proteins
     Search for Antibodies for POU5F1B at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for POU5F1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for POU5F1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU5F1B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for POU5F1B
     Browse SwitchGear Promoter luciferase reporter plasmids for POU5F1B
     ThermoFisher Antibodies for POU5F1B
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat POU5F1B
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      POU5F1B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4