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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU5F1 Gene

protein-coding   GIFtS: 68
GCID: GC06M031136

POU class 5 homeobox 1

(Previous names: POU domain class 5, transcription factor 1 )
(Previous symbol: OTF3)
 Explore 58 diseases affiliated with
POU5F1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for POU5F1    

Aliases
for POU5F1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
POU Class 5 Homeobox 11 2     Oct-42 3
OCT31 2 3 5     MGC224871
OTF31 2 3 5     Oct41
Octamer-Binding Protein 32 3     POU Domain Class 5, Transcription Factor 11
Octamer-Binding Protein 42 3     OTF42
Octamer-Binding Transcription Factor 32 3     Octamer-Binding Transcription Factor-32
OCT42 3     POU Domain Transcription Factor OCT42
OTF-32 3     POU Domain, Class 5, Transcription Factor 12
Oct-32 3     POU-Type Homeodomain-Containing DNA-Binding Protein2

External Ids:    HGNC: 92211   Entrez Gene: 54602   Ensembl: ENSG000002045317   OMIM: 1641775   UniProtKB: Q018603   

Export aliases for POU5F1 gene to outside databases

Previous GC identifers: GC08P127435 GC06M031188 GC06M030902 GC06M031238 GC06M031240 GC06M031133 GC06M030934


Summaries
for POU5F1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for POU5F1:
This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in
embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell
pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has been linked to tumor
formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple
isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on
chromosomes 1, 3, 8, 10, and 12. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on
DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and
ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency

Gene Wiki entry for POU5F1 (Oct-4)


Genomic Views
for POU5F1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU5F1 gene promoter:
         AP-1   MyoD   STAT3   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see first 1): POU5F1 promoter sequences (S722578  S722579  S722748)
   Search SABiosciences Chromatin IP Primers for POU5F1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU5F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.33

POU5F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU5F1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031136:  view genomic region     (about GC identifiers)

Start:
 31,130,253 bp from pter      End:
 31,148,508 bp from pter
Size:
 18,256 bases      Orientation:
 minus strand

6 alternative locations:
Chr6-,ALT_REF_LOCI_4 31,100,117-31,106,473      Chr6-,ALT_REF_LOCI_6 31,119,639-31,166,504      Chr6-,ALT_REF_LOCI_5 31,125,460-31,131,816     
Chr6-,ALT_REF_LOCI_3 31,120,916-31,143,234      Chr6-,ALT_REF_LOCI_2 31,119,738-31,170,206      Chr6-,ALT_REF_LOCI_7 31,056,516-31,062,869     

Proteins
for POU5F1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860 (See protein sequence)
Recommended Name: POU domain, class 5, transcription factor 1  
Size: 360 amino acids; 38571 Da
Subunit: Interacts with UBE2I and ZSCAN10 (By similarity). Interacts with PKM. Interacts with WWP2
Subcellular location: Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern
Developmental stage: Highly expressed in undifferentiated embryonic stem cells and expression decreases gradually after
embryoid body (EB) formation
Biotechnology: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are
sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem)
cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes
Miscellaneous: Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. 2 of them,
localized in chromosomes 8 and 10, are transcribed in cancer tissues but not in normal ones and may be involved in the
regulation of POU5F1 gene activity in carcinogenesis
Secondary accessions: A6NCS1 A6NLL8 D2IYK4 P31359 Q15167 Q15168 Q16422 Q5STF3 Q5STF4
Alternative splicing: 2 isoforms:  Q01860-1   Q01860-2   

Explore the universe of human proteins at neXtProt for POU5F1: NX_Q01860

Post-translational modifications:

  • Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for
    • enhanced YES1 expression (By similarity)1
  • Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q01860

    • POU5F1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001167002.1  NP_002692.2  NP_976034.4  

    ENSEMBL proteins: 
     ENSP00000259915   ENSP00000425479   ENSP00000389359   ENSP00000425083  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: POU5F1
    OriGene Protein Over-expression Lysate (see all 2): POU5F1
    OriGene Custom Protein Services for POU5F1 
    GenScript Custom Purified and Recombinant Proteins Services for POU5F1
    Novus Biologicals POU5F1 Proteins
    Novus Biologicals POU5F1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for POU5F1
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19274063
    GO:0005654nucleoplasm IDA--
    GO:0005667transcription factor complex IDA19736317
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA18000303


    POU5F1 for ontologies           About GeneDecksing



    POU5F1 Antibody Products: 
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    R&D Systems Antibodies for POU5F1 (Oct-4A, Oct-3/4)
    Cell Signaling Technology (CST) Antibodies for POU5F1  (4-Oct)
    OriGene Antibodies (see all 6): POU5F1
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    Abcam antibodies for POU5F1 
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    ThermoFisher Antibody for POU5F1

    Assay Products for POU5F1: 
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for POU5F1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    POU5F1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry Q01860

    ProtoNet protein and cluster: Q01860

    2 Blocks protein families:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860
    Domain: The POU-specific domain mediates interaction with PKM
    Similarity: Belongs to the POU transcription factor family. Class-5 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    Function
    for POU5F1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860
    Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on
    DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and
    ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency
    Induction: Transcriptional activity is positively regulated by PKM

         Genatlas biochemistry entry for POU5F1:
    POU domain,class 5,transcription factor 1,expressed in neuronal cells,with OCT5 likely a proteolytic product of OCT3

    miRNA
    Products:            		miRTarBase miRNAs that target POU5F1:
    hsa-mir-145 (MIRT004904)

    OriGene 3'-UTR Clone (see all 2): POU5F1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU5F1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate POU5F1:
    hsa-miR-3606 hsa-miR-3658 hsa-miR-103a-2* hsa-miR-3657 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmid: POU5F1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for POU5F1 (see all 7)
    OriGene shRNA RFP: POU5F1
    OriGene siRNA: POU5F1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat POU5F1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for POU5F1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for POU5F1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for POU5F1 (see all 4)
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    GenScript: all cDNA clones in your preferred vector (see all 3): POU5F1 (NM_002701)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU5F1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU5F1 

    Cell Line
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    LifeMap BioReagents: cell lines associated with POU5F1: Human Embryonic Stem Cell Line ESI-017,
    Human Embryonic Stem Cell Line ESI-035, Human Embryonic Stem Cell Line ESI-049, Human Embryonic Stem Cell Line ESI-051,
    Human Embryonic Stem Cell Line ESI-053

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU5F1

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ISS--
    GO:0003677DNA binding IDA16153702
    GO:0003700sequence-specific DNA binding transcription factor activity IDA16153702
    GO:0005515protein binding IPI15523054
    GO:0008134transcription factor binding IPI19736317


    POU5F1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for POU5F1:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Pou5f1tm1.1Scho for POU5F1
         12 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Pou5f1):
     behavior/neurological  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     hematopoietic system  integument  liver/biliary system  mortality/aging  nervous system 
     normal  reproductive system 

    POU5F1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for POU5F1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PKA activation in glucagon signalling
    		Development Role of Activin A in cell differentiation and proliferation0.33
    		Development_Role of Activin A in cell differentiation and proliferation0.33
    2Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00
    3Selected targets of Oct-3/4
    		Selected targets of Oct-3/41.00
    4Transcriptional Regulatory Network in Embryonic Stem Cell
    		Transcriptional Regulatory Network in Embryonic Stem Cell1.00
    5Oct4 in Mammalian ESC Pluripotency
    		Oct4 in Mammalian ESC Pluripotency1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for POU5F1
        Development Role of Activin A in cell differentiation and proliferation
    Selected targets of Oct-3/4

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POU5F1
        Transcriptional Regulatory Network in Embryonic Stem Cell
    Oct4 in Mammalian ESC Pluripotency
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency
    Human Early Embryo Development

    1 Cell Signaling Technology (CST) Pathway for POU5F1
        Wnt / Hedgehog / Notch

    1 GeneGo (Thomson Reuters) Pathway for POU5F1
        Development Role of Activin A in cell differentiation and proliferation

    3 BioSystems Pathways for POU5F1 
        Wnt Signaling Pathway and Pluripotency
    SIDS Susceptibility Pathways
    HIF-2-alpha transcription factor network



    POU5F1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU5F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/198 Interacting proteins for POU5F1 (Q018601, 2, 3 ENSP000002599154) via UniProtKB, MINT, STRING, and/or I2D (see all 198)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001714endodermal cell fate specification IDA--
    GO:0001824blastocyst development ISS--
    GO:0003130BMP signaling pathway involved in heart induction IMP19736317
    GO:0006355regulation of transcription, DNA-dependent IDA16153702
    GO:0006357regulation of transcription from RNA polymerase II promoter ----


    POU5F1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for POU5F1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POU5F1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for POU5F1

    2 DrugBank Compounds for POU5F1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DopamineDopamin (see all 6)51-61-6transportersubstrate20402963
    NorepinephrineArterenol (see all 4)51-41-2transportersubstrate20402963

    4 Novoseek chemical compound relationships for POU5F1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    slex 56.7 5 16894532 (2), 19755485 (1), 15342930 (1), 20177991 (1)
    retinoic acid 36.8 13 1915274 (3), 7501302 (2), 12841847 (1), 19719918 (1) (see all 8)
    vegf 8.99 1 18729794 (1), 18332870 (1)
    oxygen 0 5 19755485 (1), 20177991 (1), 16510872 (1)

    1 PharmGKB related drug/compound annotation for POU5F1 gene
    Drug/compound PharmGKB Annotation
    allopurinolCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about POU5F1 / PO5F1 

    Transcripts
    for POU5F1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for POU5F1 gene (3 alternative transcripts): 
    NM_001173531.1  NM_002701.4  NM_203289.4  

    Unigene Cluster for POU5F1:

    POU class 5 homeobox 1
    Hs.249184  [show with all ESTs]
    Unigene Representative Sequence: NM_203289
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259915(uc003nsv.3) ENST00000512818(uc021yuj.1) ENST00000513407(uc003nsu.3)
    ENST00000441888 ENST00000471529 ENST00000461401

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate POU5F1:
    hsa-miR-3606 hsa-miR-3658 hsa-miR-103a-2* hsa-miR-3657 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmid: POU5F1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU5F1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU5F1

    Additional cDNA sequence: 

    AM851115.1 AM851116.1 AM851117.1 AM851118.1 AM851119.1 AM851120.1 AM851121.1 AM851122.1 
    AM851123.1 AM851124.1 AM851125.1 AM851126.1 BC020712.1 BC069246.1 BC117435.1 BC117437.1 
    DQ486515.1 DQ486516.1 DQ486517.1 FM177951.1 FM177952.1 FM177953.1 FM177954.1 FM177955.1 
    FM177956.1 FM177957.1 FM177958.1 FM177959.1 FM177960.1 FM177961.1 FM177962.1 FM177963.1 
    FM177964.1 FM177965.1 FM177966.1 FM177967.1 FM177968.1 S81255.1 Z11898.1 Z11899.1 

    8 DOTS entries:

    DT.75142423  DT.100791936  DT.100018840  DT.102825540  DT.100791937  DT.121173762  DT.121322086  DT.75109570 

    9 AceView cDNA sequences:

    Z11899 NM_002701 BC020712 NM_203289 BC069246 Z11898 BF930231 BF871564 
    S81255 

    GeneLoc Exon Structure


    Expression
    for POU5F1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU5F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATCACTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    POU5F1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/26 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 26) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EpiblastEpiblastEarly Epiblast CellsEarly Embryo
    EpiblastEpiblastPrimordial Germ Cell PrecursorsGerm Cells
    Inner Cell MassInner Cell MassInner Cell Mass CellsEarly Embryo
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    OvaryOvigerous CordOogoniaFemale Gametocytes, Germ Cells
    OvaryOvigerous CordXX Germ CellsFemale Gametocytes, Germ Cells
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    OvaryPrimordial FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    TestisSeminiferous TubulesSpermatogonial Stem CellsGerm Cells, Male Gametocytes
    TestisSeminiferous TubulesSpermatogonium Type AGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/141 LifeMap Cells (see all 141) 
    NameCategory
    Induced pluripotent stem cell line 20D17 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line 492B4 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Human umbilical vein endothelial cell-derived induced pluripotent stem cells (Induced Pluripotent Stem Cell)Early Embryo, Endothelium
    BJ fibroblast-derived induced pluripotent stem cells (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line 201B6 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line 253G1 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line A6 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line Bi 1-3 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line hIPS1 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line hIPS2 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast

    See POU5F1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POU5F1

    SOURCE GeneReport for Unigene cluster: Hs.249184

    UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860
    Tissue specificity: Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the
    olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including POU5F1 (see all 6): 
              Cell Lineage Identification in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
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    Orthologs
    for POU5F1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for POU5F1 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 55(a)
    		 1 → many
    		 GL343623.1(305954-310934)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.232762 Xenopus laevis transcribed sequence with moderate similarity more 80.05(n)    BQ900469.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii pou5f12 POU domain, class 5, transcription factor 1 74.89(n)   30333  NM_131112.1 


    ENSEMBL Gene Tree for POU5F1 (if available)
    TreeFam Gene Tree for POU5F1 (if available) 

    Paralogs
    for POU5F1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POU5F1 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F42  POU3F12  POU1F12  POU4F32  
    POU3F32  POU3F22  POU2F22  POU5F1B2  POU2F12  POU4F12  POU6F12  
    15 SIMAP similar genes for POU5F1 using alignment to 53 protein entries:     PO5F1_HUMAN (see all proteins):
    POU5F1B    POU5F1P1    POU5F1P4    POU5F1P3    OCT6    POU1F1
    POU3F4    POU6F1    POU3F2    POU5F2    POU2F1    POU2F3
    POU3F1    POU2F2    OCT-2

    POU5F1 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for POU5F1 (see all 6)
    PGOHUM00000239313 PGOHUM00000245013 PGOHUM00000237756 PGOHUM00000238106 PGOHUM00000235313


    Genomic Variants
    for POU5F1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/231 NCBI SNPs in POU5F1 are shown (see all 231)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs178400231,2
    		C,F,H,--31131698(+) ACTTAT/CGGGCA 5 -- ut31 ds50015Minor allele frequency- C:0.01NA NS 484
    rs1836092841,2
    		--31131699(+) CTTATA/GGGCAG 5 -- ds5001 ut310--------
    rs95010621,2
    		C,F,A,H,--31131707(+) CAGAGT/CATGCA 5 -- ds5001 ut3118Minor allele frequency- C:0.11MN NS EA WA NA 2430
    rs1875527861,2
    		--31131725(+) TAAGTA/GGAAAC 5 -- ut31 ds50010--------
    rs1450449391,2
    		--31131788(+) TGGGGA/TGATCT 5 -- ds5001 ut310--------
    rs11507661,2
    		C,H--31131793(-) AACCTA/TGATCA 5 -- ut31 ds50015Minor allele frequency- T:0.00MN NS EA 592
    rs1164936521,2
    		C,F,--31131796(+) TCTAGG/ATTCAA 5 -- ut31 ds50011Minor allele frequency- A:0.02WA 118
    rs171908111,2
    		C,F,--31131837(+) CATTTA/TAGAAT 5 -- ds5001 ut314Minor allele frequency- T:0.06MN WA NA EA 450
    rs1423484211,2
    		--31131953(+) AGCCTA/GTCACA 5 -- ds5001 ut310--------
    rs560327101,2
    		C--31132062(+) GGGTAC/TGAGCA 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for POU5F1 (31130253 - 31148508 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for POU5F1
         1 CNV: 3601
    Human Gene Mutation Database (HGMD): POU5F1

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    Disorders / Diseases
    for POU5F1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    POU5F1 for disorders           About GeneDecksing

    OMIM gene information: 164177    OMIM disorders: --

    20/58 diseases for POU5F1 (see all 58):    About MalaCards
    central nervous system germinoma    sarcoma    immature teratoma of ovary    sacrococcygeal teratoma
    germinoma    testicular germ cell tumor    pineoblastoma    germ cell tumor
    teratoma    squamous cell carcinoma    pituitary adenoma    urinary bladder cancer
    oral squamous cell carcinoma    esophageal squamous cell carcinoma    systemic lupus erythematosus    yaws
    lupus erythematosus    gonadoblastoma    chronic myeloid leukemia    teratocarcinoma

    5 diseases from the University of Copenhagen DISEASES database for POU5F1:
    Teratoma     Gonadoblastoma     Embryonal carcinoma     Seminoma
    Dysgerminoma

    10/15 Novoseek disease relationships for POU5F1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 74.8 16 8662786 (2), 15725806 (1), 17314394 (1), 10328600 (1) (see all 13)
    teratoma 73.9 8 18439155 (1), 19826408 (1), 16494961 (1), 12161760 (1) (see all 8)
    pineoblastoma 46.3 1 15725806 (1)
    seminoma 44.6 4 15725806 (1), 17682839 (1), 17117392 (1)
    germinoma 36.7 6 15725806 (4), 17117392 (1)
    teratocarcinoma 33.4 1 8453995 (1)
    tumors 18 38 17205510 (5), 18701476 (3), 16510872 (3), 15513931 (2) (see all 22)
    cancer 17.3 23 17261754 (2), 16229821 (2), 16854382 (2), 18701476 (2) (see all 13)
    ewings sarcoma 16 3 15917470 (2), 20051954 (1), 17564582 (1)
    carcinoma 8.24 3 15342930 (1), 18614581 (1), 19876845 (1)

    Genetic Association Database (GAD): POU5F1
    Human Genome Epidemiology (HuGE) Navigator: POU5F1 (7 documents)

    Export disorders for POU5F1 gene to outside databases

    Publications
    for POU5F1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU5F1 gene, integrated from 9 sources (see all 469):
    (articles sorted by number of sources associating them with POU5F1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. (PubMed id 1408763)1, 2, 3, 9 Takeda J.... Bell G.I. (1992)
    2. Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. (PubMed id 18191611)1, 2, 9 Lee J.... Kim J. (2008)
    3. Oct4 pseudogenes are transcribed in cancers. (PubMed id 16229821)1, 2, 9 Suo G.... Dai J. (2005)
    4. A study of candidate genes for psoriasis near HLA-C in Chinese patients with psoriasis. (PubMed id 12653732)1, 4, 9 Chang Y.T....Wong C.K. (2003)
    5. WWP2 promotes degradation of transcription factor OCT 4 in human embryonic stem cells. (PubMed id 19274063)1, 2 Xu H....Jin Y. (2009)
    6. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PubMed id 16702430)1, 2 Shiina T.... Bahram S. (2006)
    7. Expression of transcription regulating genes in human preimplantation embryos. (PubMed id 8567814)1, 2 Abdel-Rahman B.... Pergament E. (1995)
    8. Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation. (PubMed id 17525163)1, 9 Wei F....Atchison M.L. (2007)
    9. Stimulation of Oct-4 activity by Ewing's sarcoma protein. (PubMed id 15917470)1, 9 Lee J....Kim J. (2005)
    10. OCT-4, an embryonic stem cell marker, is highly expressed in bladder cancer. (PubMed id 17205510)1, 9 Atlasi Y....Bahrami A.R. (2007)

    External Searches for POU5F1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing POU5F1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5460 HGNC: 9221 AceView: POU5F1 Ensembl:ENSG00000204531 euGenes: HUgn5460
    ECgene: POU5F1 H-InvDB: POU5F1

    Other Databases showing POU5F1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing POU5F1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for POU5F1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Oct-4

    Intellectual Property
    for POU5F1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for POU5F1 gene:
    Search GeneIP for patents involving POU5F1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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