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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

POU5F1 Gene

protein-coding   GIFtS: 69
GCID: GC06M031136

POU Class 5 Homeobox 1

(Previous names: POU domain class 5, transcription factor 1)
(Previous symbol: OTF3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
POU Class 5 Homeobox 11 2     Oct-32 3
OTF31 2 3 5     Oct-42 3
OCT32 3 5     POU Domain Class 5, Transcription Factor 11
Octamer-Binding Protein 32 3     OTF42
Octamer-Binding Protein 42 3     Octamer-Binding Transcription Factor-32
Octamer-Binding Transcription Factor 32 3     POU Domain Transcription Factor OCT42
OCT42 3     POU Domain, Class 5, Transcription Factor 12
OTF-32 3     POU-Type Homeodomain-Containing DNA-Binding Protein2

External Ids:    HGNC: 92211   Entrez Gene: 54602   Ensembl: ENSG000002045317   OMIM: 1641775   UniProtKB: Q018603   

Export aliases for POU5F1 gene to outside databases

Previous GC identifers: GC08P127435 GC06M031188 GC06M030902 GC06M031238 GC06M031240 GC06M031133 GC06M030934


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for POU5F1 Gene:
This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in
embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell
pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has been linked to
tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in
multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been
identified on chromosomes 1, 3, 8, 10, and 12. (provided by RefSeq, Mar 2010)

GeneCards Summary for POU5F1 Gene: 
POU5F1 (POU class 5 homeobox 1) is a protein-coding gene. Diseases associated with POU5F1 include central nervous system germinoma, and immature teratoma of ovary, and among its related super-pathways are GSK3 Signaling and Wnt Signaling Pathway. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with
SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1,
FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency

Gene Wiki entry for POU5F1 (Oct-4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the POU5F1 gene promoter:
         AP-1   MyoD   STAT3   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): POU5F1 promoter sequence
   Search SABiosciences Chromatin IP Primers for POU5F1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat POU5F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.33

POU5F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU5F1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031136:  view genomic region     (about GC identifiers)

Start:
31,132,114 bp from pter      End:
31,148,508 bp from pter
Size:
16,395 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167248 2,427,966-2,434,320      Chr6-,NT_167247 2,514,037-2,520,393      Chr6-,NT_167245 2,429,238-2,435,593     
Chr6-,NT_167246 2,480,458-2,486,814      Chr6-,NT_167249 2,467,051-2,473,404      Chr6-,NT_113891.2 2,646,867-2,653,222     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860 (See protein sequence)
Recommended Name: POU domain, class 5, transcription factor 1  
Size: 360 amino acids; 38571 Da
Subunit: Interacts with UBE2I and ZSCAN10 (By similarity). Interacts with PKM. Interacts with WWP2
Subcellular location: Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern
Developmental stage: Highly expressed in undifferentiated embryonic stem cells and expression decreases gradually
after embryoid body (EB) formation
Biotechnology: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors
are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent
stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes
Miscellaneous: Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. 2 of them,
localized in chromosomes 8 and 10, are transcribed in cancer tissues but not in normal ones and may be involved
in the regulation of POU5F1 gene activity in carcinogenesis
Secondary accessions: A6NCS1 A6NLL8 D2IYK4 P31359 Q15167 Q15168 Q16422 Q5STF3 Q5STF4
Alternative splicing: 2 isoforms:  Q01860-1   Q01860-2   

Explore the universe of human proteins at neXtProt for POU5F1: NX_Q01860

Explore proteomics data for POU5F1 at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for
    enhanced YES1 expression (By similarity)
  • UniProtKB: Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation (By
    similarity)
  • UniProtKB: ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation
    at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q01860

  • POU5F1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    POU5F1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001167002.1  NP_002692.2  NP_976034.4  

    ENSEMBL proteins: 
     ENSP00000389359   ENSP00000259915   ENSP00000425479   ENSP00000475880   ENSP00000475512  
     ENSP00000425083  

    Human Recombinant Protein Products for POU5F1: 
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    Novus Biologicals POU5F1 Proteins
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for POU5F1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18000303
    GO:0005654nucleoplasm IDA--
    GO:0005667transcription factor complex IDA19736317
    GO:0005737cytoplasm IDA18281244
    GO:0005829cytosol IDA18000303

    POU5F1 for ontologies           About GeneDecksing



    POU5F1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of POU5F1
    R&D Systems Antibodies for POU5F1 (Oct-4A, Oct-3/4)
    Cell Signaling Technology (CST) Antibodies for POU5F1  (4-Oct)
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    Abcam antibodies for POU5F1
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    ThermoFisher Antibody for POU5F1
    LSBio Antibodies in human, mouse, rat for POU5F1 

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    OriGene Custom Assay Services for POU5F1
    R&D Systems Transcription Factor Binding & Immunoprecipitation Assays for POU5F1 (Oct-3/4)         (see first)
    R&D Systems Proteome Profiler Antibody Arrays for POU5F1 (Oct-3/4)
    See all other biochemical assays at R&D Systems
    GenScript Custom Assay Services for POU5F1
    Cell Signaling Technology (CST) Sandwich ELISA Kits for POU5F1 (4-Oct)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    POU: Homeoboxes / POU class

    5/7 InterPro protein domains (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry Q01860

    ProtoNet protein and cluster: Q01860

    2 Blocks protein domains:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860
    Domain: The POU-specific domain mediates interaction with PKM
    Similarity: Belongs to the POU transcription factor family. Class-5 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    POU5F1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO5F1_HUMAN, Q01860
    Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with
    SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1,
    FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency
    Induction: Transcriptional activity is positively regulated by PKM

         Genatlas biochemistry entry for POU5F1:
    POU domain,class 5,transcription factor 1,expressed in neuronal cells,with OCT5 likely a proteolytic product of
    OCT3

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ISS--
    GO:0003677DNA binding IDA16153702
    GO:0003700sequence-specific DNA binding transcription factor activity IDA16153702
    GO:0005515protein binding IPI11099378
    GO:0008134transcription factor binding IPI19736317
         
    POU5F1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for POU5F1:
     Increased gamma-H2AX phosphory 

         12 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Pou5f1):
     behavior/neurological  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     hematopoietic system  integument  liver/biliary system  mortality/aging  nervous system 
     normal  reproductive system 

    POU5F1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pou5f1tm1.1Scho for POU5F1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for POU5F1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for POU5F1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU5F1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU5F1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target POU5F1:
    hsa-mir-145 (MIRT004904)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat POU5F1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate POU5F1:
    hsa-miR-3606 hsa-miR-3658 hsa-miR-103a-2* hsa-miR-3657 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidPOU5F1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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                         Customized adenovirus for overexpression of POU5F1

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): POU5F1 (NM_002701)
    Sino Biological Human cDNA Clone for POU5F1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU5F1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU5F1
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                         Customized lentivirus expression plasmids for stable overexpression of POU5F1 

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    Human Embryonic Stem Cell Line ESI-035, Human Embryonic Stem Cell Line ESI-049,
    Human Embryonic Stem Cell Line ESI-051, Human Embryonic Stem Cell Line ESI-053
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU5F1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for POU5F1 About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    2Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency0.55
    3Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency0.50
    4PKA activation in glucagon signalling
    Development Role of Activin A in cell differentiation and proliferation0.33
    5Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for POU5F1
        Development Role of Activin A in cell differentiation and proliferation
    Selected targets of Oct-3/4

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for POU5F1
        Transcriptional Regulatory Network in Embryonic Stem Cell
    Oct4 in Mammalian ESC Pluripotency
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency
    Human Early Embryo Development

    1 Cell Signaling Technology (CST) Pathway for POU5F1
        Wnt / Hedgehog / Notch

    1 GeneGo (Thomson Reuters) Pathway for POU5F1
        Development Role of Activin A in cell differentiation and proliferation

    4 BioSystems Pathways for POU5F1
        Wnt Signaling Pathway and Pluripotency
    SIDS Susceptibility Pathways
    Cardiac Progenitor Differentiation
    HIF-2-alpha transcription factor network




    POU5F1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for POU5F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/203 Interacting proteins for POU5F1 (Q018601, 2, 3 ENSP000002599154) via UniProtKB, MINT, STRING, and/or I2D (see all 203)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001714endodermal cell fate specification IDA--
    GO:0001824blastocyst development ISS--
    GO:0003130BMP signaling pathway involved in heart induction IMP19736317
    GO:0006355regulation of transcription, DNA-dependent IDA16153702
    GO:0006366transcription from RNA polymerase II promoter ISS--

    POU5F1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    POU5F1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for POU5F1 (PO5F1)

    2 DrugBank Compounds for POU5F1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DopamineDopamin (see all 6)51-61-6transportersubstrate20402963
    NorepinephrineArterenol (see all 4)51-41-2transportersubstrate20402963

    4 Novoseek inferred chemical compound relationships for POU5F1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    slex 56.7 5 16894532 (2), 19755485 (1), 15342930 (1), 20177991 (1)
    retinoic acid 36.8 13 1915274 (3), 7501302 (2), 12841847 (1), 19719918 (1) (see all 8)
    vegf 8.99 1 18729794 (1), 18332870 (1)
    oxygen 0 5 19755485 (1), 20177991 (1), 16510872 (1)

    1 PharmGKB related drug/compound annotation for POU5F1 gene    About this table
    Drug/compound PharmGKB Annotation
    allopurinolCA  

    Search CenterWatch for drugs/clinical trials and news about POU5F1 / PO5F1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for POU5F1 gene (3 alternative transcripts): 
    NM_001173531.1  NM_002701.4  NM_203289.4  

    Unigene Cluster for POU5F1:

    POU class 5 homeobox 1
    Hs.249184  [show with all ESTs]
    Unigene Representative Sequence: NM_203289
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441888 ENST00000259915(uc003nsv.3) ENST00000512818(uc021yuj.1)
    ENST00000606567 ENST00000513407(uc003nsu.3) ENST00000471529 ENST00000461401

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    SwitchGear 3'UTR luciferase reporter plasmidPOU5F1 3' UTR sequence
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU5F1
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    Additional mRNA sequence: 

    AM851115.1 AM851116.1 AM851117.1 AM851118.1 AM851119.1 AM851120.1 AM851121.1 AM851122.1 
    AM851123.1 AM851124.1 AM851125.1 AM851126.1 BC020712.1 BC069246.1 BC117435.1 BC117437.1 
    DQ486515.1 DQ486516.1 DQ486517.1 FM177951.1 FM177952.1 FM177953.1 FM177954.1 FM177955.1 
    FM177956.1 FM177957.1 FM177958.1 FM177959.1 FM177960.1 FM177961.1 FM177962.1 FM177963.1 
    FM177964.1 FM177965.1 FM177966.1 FM177967.1 FM177968.1 S81255.1 Z11898.1 Z11899.1 

    8 DOTS entries:

    DT.75142423  DT.100791936  DT.100018840  DT.102825540  DT.100791937  DT.121173762  DT.121322086  DT.75109570 

    9 AceView cDNA sequences:

    Z11899 BC020712 BC069246 NM_002701 NM_203289 Z11898 BF871564 BF930231 
    S81255 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    POU5F1 expression in normal human tissues (normalized intensities)      POU5F1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCACTTTT
    POU5F1 Expression
    About this image


    POU5F1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 122 entries
             Inner Cell Mass Cells Inner Cell Mass
             CA2
             Matrigel embedded cells ( Derivation of cardiomyocytes from pluripotent stem cells...
             ESI-053   
     
     Gonad
             Oogonia Ovigerous Cord
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 7 entries
             Primordial Germ Cell Precursors Epiblast
             Epiblast Stem Cells
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 7 entries
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)    fully expand to see all 6 entries
             Oogonia Ovigerous Cord

    See POU5F1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for POU5F1

    SOURCE GeneReport for Unigene cluster: Hs.249184

    UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860
    Tissue specificity: Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the
    olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including POU5F1 (see all 6): 
              Cell Lineage Identification in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for POU5F1
    OriGene qSTAR qPCR primer pairs in human, mouse for POU5F1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat POU5F1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat POU5F1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat POU5F1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU5F1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for POU5F1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou5f11 , 5 POU domain, class 5, transcription factor 11, 5 83.71(n)1
    86.08(a)1
      17 (18.69 cM)5
    189991  NM_013633.31  NP_038661.21 
     355060375 
    chicken
    (Gallus gallus)
    Aves POUV6
    POU domain class 5 transcription factor 1
    41(a)
    possible ortholog
    17(460123-461472)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    57(a)
    1 → many
    GL343623.1(305510-323263)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.232762 Xenopus laevis transcribed sequence with moderate similarity more 80.05(n)    BQ900469.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pou5f12 POU domain, class 5, transcription factor 1 74.89(n)   30333  NM_131112.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-186
    Homeobox protein ceh-18
    15(a)
    1 → many
    X(3843827-3857797)


    ENSEMBL Gene Tree for POU5F1 (if available)
    TreeFam Gene Tree for POU5F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for POU5F1 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F12  POU3F42  POU1F12  POU3F32  
    POU4F32  POU3F22  POU2F22  POU5F1B2  POU4F12  POU2F12  POU6F12  
    14 SIMAP similar genes for POU5F1 using alignment to 52 protein entries:     PO5F1_HUMAN (see all proteins):
    POU5F1B    POU5F1P1    POU5F1P4    POU5F1P3    OCT6    POU1F1
    POU3F4    POU6F1    POU3F2    POU5F2    POU2F1    POU2F3
    POU3F1    POU2F2

    POU5F1 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for POU5F1 (see all 6)
    PGOHUM00000239313 PGOHUM00000245013 PGOHUM00000237756 PGOHUM00000238106 PGOHUM00000235313


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/226 SNPs in POU5F1 are shown (see all 226)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0462044
    ----see VAR_0462042 T I mis40--------
    VAR_0037754
    ----see VAR_0037752 M L mis40--------
    VAR_0037744
    ----see VAR_0037742 T A mis40--------
    rs23948821,2
    C,F,A,H--31132649(+) CCTGCC/AAGTGA 3 -- int130Minor allele frequency- A:0.32NS EA NA WA CSA EU 4126
    rs92637951,2
    C,F,H--31132656(+) GTGAAT/CGACAG 3 -- int16Minor allele frequency- C:0.06EA NS NA EU 1607
    rs1919683711,2
    C,F--31132676(+) TGACAT/CTAGAC 3 -- int11Minor allele frequency- C:0.00EU 1063
    rs1827553761,2
    --31132710(+) CTGCTC/TGGACA 3 -- int10--------
    rs92637961,2
    C,F,H--31132883(+) GAGCCC/TGCAGA 3 -- int121Minor allele frequency- T:0.13NS EA NA WA CSA EU 3563
    rs178518181,2
    C,F--31132956(+) AGTGTG/CGGTTT 6 /P syn1 ese38Minor allele frequency- C:0.07NA EA WA EU 6766
    rs11507671,2,4
    C,F,H--31133045(-) AAACCC/TTCGTG 6 L F mis1 ese310Minor allele frequency- T:0.03MN NS EA NA 922

    HapMap Linkage Disequilibrium report for POU5F1 (31132114 - 31148508 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for POU5F1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2731791CNV Deletion23290073
    nsv524061CNV Loss19592680
    nsv525933CNV Loss19592680
    nsv428140CNV Gain+Loss18775914
    esv690CNV CNV17122850
    dgv1919e1CNV Complex17122850
    dgv1918e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): POU5F1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing POU5F1
    DNA2.0 Custom Variant and Variant Library Synthesis for POU5F1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164177    OMIM disorders: --

    20/63 diseases for POU5F1 (see all 63):    About MalaCards
    central nervous system germinoma    immature teratoma of ovary    sacrococcygeal teratoma    germinoma
    yaws    pineoblastoma    teratoma    malignant germ cell tumor
    mixed germ cell tumor    toxic epidermal necrolysis    germ cell cancer    gonadoblastoma
    teratocarcinoma    dysgerminoma    seminoma    stevens-johnson syndrome
    gonadal dysgenesis    papillary renal cell carcinoma    turner syndrome    werner syndrome

    5 diseases from the University of Copenhagen DISEASES database for POU5F1:
    Teratoma     Gonadoblastoma     Embryonal carcinoma     Seminoma
    Dysgerminoma

    POU5F1 for disorders           About GeneDecksing

    10/15 Novoseek inferred disease relationships for POU5F1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 74.8 16 8662786 (2), 15725806 (1), 17314394 (1), 10328600 (1) (see all 13)
    teratoma 73.9 8 18439155 (1), 19826408 (1), 16494961 (1), 12161760 (1) (see all 8)
    pineoblastoma 46.3 1 15725806 (1)
    seminoma 44.6 4 15725806 (1), 17682839 (1), 17117392 (1)
    germinoma 36.7 6 15725806 (4), 17117392 (1)
    teratocarcinoma 33.4 1 8453995 (1)
    tumors 18 38 17205510 (5), 18701476 (3), 16510872 (3), 15513931 (2) (see all 22)
    cancer 17.3 23 17261754 (2), 16229821 (2), 16854382 (2), 18701476 (2) (see all 13)
    ewings sarcoma 16 3 15917470 (2), 20051954 (1), 17564582 (1)
    carcinoma 8.24 3 15342930 (1), 18614581 (1), 19876845 (1)

    Genetic Association Database (GAD): POU5F1
    Human Genome Epidemiology (HuGE) Navigator: POU5F1 (7 documents)

    Export disorders for POU5F1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for POU5F1 gene, integrated from 9 sources (see all 506) (see top 10):
    (articles sorted by number of sources associating them with POU5F1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. (PubMed id 1408763)1, 2, 3, 9 Takeda J.... Bell G.I. (1992)
    2. Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. (PubMed id 18191611)1, 2, 9 Lee J.... Kim J. (2008)
    3. Oct4 pseudogenes are transcribed in cancers. (PubMed id 16229821)1, 2, 9 Suo G.... Dai J. (2005)
    4. A study of candidate genes for psoriasis near HLA-C in Chinese patients with psoriasis. (PubMed id 12653732)1, 4, 9 Chang Y.T....Wong C.K. (2003)
    5. Serine 111 phosphorylation regulates OCT4A protein sub cellular distribution and degradation. (PubMed id 23024368)1, 2 Spelat R....Curcio F. (2012)
    6. Phosphorylation regulates human OCT4. (PubMed id 22474382)1, 2 Brumbaugh J....Thomson J.A. (2012)
    7. Genome-wide association study of Stevens-Johnson Synd rome and Toxic Epidermal Necrolysis in Europe. (PubMed id 21801394)1, 4 GAcnin E....Mockenhaupt M. (2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    9. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Tevfik Dorak M. (2010)
    10. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (2009)
    11. WWP2 promotes degradation of transcription factor OCT 4 in human embryonic stem cells. (PubMed id 19274063)1, 2 Xu H....Jin Y. (2009)
    12. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PubMed id 16702430)1, 2 Shiina T.... Bahram S. (2006)
    13. Expression of transcription regulating genes in human preimplantation embryos. (PubMed id 8567814)1, 2 Abdel-Rahman B.... Pergament E. (1995)
    14. Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation. (PubMed id 17525163)1, 9 Wei F....Atchison M.L. (2007)
    15. Stimulation of Oct-4 activity by Ewing's sarcoma protein. (PubMed id 15917470)1, 9 Lee J....Kim J. (2005)
    16. OCT-4, an embryonic stem cell marker, is highly expressed in bladder cancer. (PubMed id 17205510)1, 9 Atlasi Y....Bahrami A.R. (2007)
    17. Conserved and divergent patterns of expression of DAZL, VASA and OCT4 in the germ cells of the human fetal ovary and testis. (PubMed id 18088417)1, 9 Anderson R.A....Saunders P.T. (2007)
    18. Oct-4 controls cell-cycle progression of embryonic st em cells. (PubMed id 19968627)1, 9 Lee J....Kim J. (2010)
    19. Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4. (PubMed id 11689681)1, 9 Ezashi T....Roberts R.M. (2001)
    20. Upregulation of Oct-4 isoforms in pulmonary artery sm ooth muscle cells from patients with pulmonary arterial hypertension. (PubMed id 20139178)1, 9 Firth A.L....Yuan J.X. (2010)
    21. Oct4 is expressed in human gliomas and promotes colony formation in glioma cells. (PubMed id 18985733)1, 9 Du Z....Hao A. (2009)
    22. Effects of ectopic Nanog and Oct4 overexpression on m esenchymal stem cells. (PubMed id 19102659)1, 9 Liu T.M....Lim B. (2009)
    23. Oct-4 expression in adult human differentiated cells challenges its role as a pure stem cell marker. (PubMed id 17379765)1, 9 Zangrossi S....Lazzari L. (2007)
    24. The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells. (PubMed id 12841847)1, 9 Wang P....Jin T. (2003)
    25. Oct4 is expressed in Nestin-positive cells as a marker for pancreatic endocrine progenitor. (PubMed id 19224238)1, 9 Wang H....Li L. (2009)
    26. Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract. (PubMed id 17314394)1, 9 Freberg C.T....Collas P. (2007)
    27. Transcriptional regulation of the Oct4 gene, a master gene for pluripotency. (PubMed id 20054811)1, 9 Kellner S. and Kikyo N. (2010)
    28. Oct-4 expression in human endometrium. (PubMed id 16421218)1, 9 Matthai C....Kolbus A. (2006)
    29. Pluripotency factors Lin28 and Oct4 identify a sub-po pulation of stem cell-like cells in ovarian cancer. (PubMed id 20101213)1, 9 Peng S....Huang Y. (2010)
    30. Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells. (PubMed id 18612434)1, 9 Chen Y.C....Chiou S.H. (2008)
    31. Transcriptional regulation of human Oct4 by steroidogenic factor-1. (PubMed id 17226773)1, 9 Yang H.M....Kim J.H. (2007)
    32. Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis. (PubMed id 15513931)1, 9 Tai M.H....Trosko J.E. (2005)
    33. Specific knockdown of Oct4 and beta2-microglobulin expression by RNA interference in human embryonic stem cells and embryonic carcinoma cells. (PubMed id 15342930)1, 9 Matin M.M....Andrews P.W. (2004)
    34. The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. (PubMed id 11891324)1, 9 Guo Y.... Hromas R. (2002)
    35. EWS-Oct-4B, an alternative EWS-Oct-4 fusion gene, is a potent oncogene linked to human epithelial tumours. (PubMed id 20051954)1, 9 Kim S....Kim J. (2010)
    36. Direct reprogramming of human neural stem cells by OC T4. (PubMed id 19718018)1, 9 Kim J.B....SchAPler H.R. (2009)
    37. Zfp143 regulates Nanog through modulation of Oct4 binding. (PubMed id 18687992)1, 9 Chen X....Ng H.H. (2008)
    38. Oct-4, Rex-1, and Gata-4 expression in human MSC increase the differentiation efficiency but not hTERT expression. (PubMed id 17211834)1, 9 Roche S....Favrot M.C. (2007)
    39. POU5F1 isoforms show different expression patterns in human embryonic stem cells and preimplantation embryos. (PubMed id 16916925)1, 9 Cauffman G....Van de Velde H. (2006)
    40. Sequential DNA methylation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differentiation. (PubMed id 15615706)1, 9 Deb-Rinker P....Walker P.R. (2005)
    41. Relationships between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines. (PubMed id 19969351)1, 9 Marques D.S....Trindade G.S. (2010)
    42. Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. (PubMed id 18593985)1, 9 Chiou S.H....Lo J.F. (2008)
    43. Evidence for the presence of stem cell-like progenitor cells in human adult pancreas. (PubMed id 18000303)1, 9 Zhao M....Huang G.C. (2007)
    44. Characterization of putative cis-regulatory elements that control the transcriptional activity of the human Oct4 promoter. (PubMed id 16149048)1, 9 Yang H.M....Kim J.H. (2005)
    45. Core transcriptional regulatory circuitry in human embryonic stem cells. (PubMed id 16153702)1, 9 Boyer L.A....Young R.A. (2005)
    46. Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. (PubMed id 12923055)1, 9 Remenyi A....Wilmanns M. (2003)
    47. Stoichiometric and temporal requirements of Oct4, Sox 2, Klf4, and c-Myc expression for efficient human iPSC induction and differenti ation. (PubMed id 19549847)1, 9 Papapetrou E.P....Sadelain M. (2009)
    48. Immunohistochemical localization of nanog and Oct4 in stem cell compartments of human sacrococcygeal teratomas. (PubMed id 18439155)1, 9 Busch C....Drews U. (2008)
    49. Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. (PubMed id 18388306)1, 9 Fong H....Donovan P.J. (2008)
    50. Independent prognostic value of the basal-like phenotype of breast cancer and associations with EGFR and candidate stem cell marker BMI-1. (PubMed id 18269588)1, 9 Arnes J.B....Akslen L.A. (2008)
    51. Aberrant expression and distribution of the OCT-4 transcription factor in seminomas. (PubMed id 17682839)1, 9 Cheng C.J....Huang Y.H. (2007)
    52. Unique kinetics of Oct3/4 microlocalization following dissociation of human embryonic stem cell colonies. (PubMed id 22727933)1 Ichikawa H....Sasaki K. (2013)
    53. Itch, an E3 ligase of Oct4, is required for embryonic stem cell self-renewal and pluripotency induction. (PubMed id 23255053)1 Liao B....Jin Y. (2013)
    54. OCT4 increases BIRC5 and CCND1 expression and promotes cancer progression in hepatocellular carcinoma. (PubMed id 23433354)1 Cao L....Su C. (2013)
    55. Differential expression of oct4 variants and pseudogen es in normal urothelium and urothelial cancer. (PubMed id 23933063)1 Wezel F....Southgate J. (2013)
    56. Cytoplasmic staining of OCT4 is a highly sensitive mar ker of adrenal medullary-derived tissue. (PubMed id 23588367)1 Alexander R.E....Idrees M. (2013)
    57. A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. (PubMed id 21912425)1 Tohkin M....Ikezawa Z. (2013)
    58. MBD6 is a direct target of Oct4 and controls the stemn ess and differentiation of adipose tissue-derived stem cells. (PubMed id 23052207)1 Jung J.S....Kang S.K. (2013)
    59. b-Catenin/POU5F1/SOX2 transcription factor complex med iates IGF-I receptor signaling and predicts poor prognosis in lung adenocarcinom a. (PubMed id 23539445)1 Xu C....Bian X.W. (2013)
    60. Usefulness of OCT4/3 immunostain in pediatric malignan t germ cell tumors. (PubMed id 22506928)1 Talebagha S....Shehata B.M. (2013)
    61. The detrimental effects of diabetes on pluripotency de termined by KLF4, SOX2, C-MYC and OCT4 immunoreactivity in rat testes. (PubMed id 23828673)1 Aktug H....Oktem G. (2013)
    62. Increased chemosensitivity via targeting testicular nu clear receptor 4 (TR4)-Oct4-interleukin 1 receptor antagonist (IL1Ra) axis in pr ostate cancer CD133+ stem/progenitor cells to battle prostate cancer. (PubMed id 23609451)1 Yang D.R....Chang C. (2013)
    63. Generation and characterisation of cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature. (PubMed id 23349823)1 Barr M.P....O'Byrne K.J. (2013)
    64. Expression of the pluripotent transcription factor OCT 4 promotes cell migration in endometriosis. (PubMed id 23290742)1 Chang J.H....Tzeng C.R. (2013)
    65. Breaking through an epigenetic wall: re-activation of Oct4 by KRAB-containing designer zinc finger transcription factors. (PubMed id 23314702)1 Juarez-Moreno K....Blancafort P. (2013)
    66. MicroRNA-302 increases reprogramming efficiency via re pression of NR2F2. (PubMed id 23136034)1 Hu S....Wu J.C. (2013)
    67. Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Na nog, and Sox2 in human embryonic stem cell self-renewal. (PubMed id 23541921)1 Wang Y....Liu H. (2013)
    68. Effects of donor fibroblasts expressing OCT4 on bovine embryos generated by somatic cell nuclear transfer. (PubMed id 23276226)1 Goissis M.D....Cibelli J.B. (2013)
    69. Cisplatin hypersensitivity of testicular germ cell tum ors is determined by high constitutive Noxa levels mediated by Oct-4. (PubMed id 23302226)1 Gutekunst M....van der Kuip H. (2013)
    70. C-MYC controlled TIP110 protein expression regulates O CT4 mRNA splicing in human embryonic stem cells. (PubMed id 23088399)1 Liu Y....He J.J. (2013)
    71. Positive correlation of Oct4 and ABCG2 to chemotherape utic resistance in CD90(+)CD133(+) liver cancer stem cells. (PubMed id 23438193)1 Jia Q....Gao J. (2013)
    72. A signature for induced pluripotent stem cell-associat ed genes in colorectal cancer. (PubMed id 23307247)1 Liu Y.H....Li J.M. (2013)
    73. Oct-4 is required for an antiapoptotic behavior of che moresistant colorectal cancer cells enriched for cancer stem cells: effects asso ciated with STAT3/Survivin. (PubMed id 23340171)1 Wen K....Qian J. (2013)
    74. Expression of stem-cell markers OCT-4 and CD133: impor tant prognostic factors in papillary renal cell carcinoma. (PubMed id 22944295)1 Kim K....Cho Y.M. (2012)
    75. Implications of transcriptional factor, OCT-4, in huma n bladder malignancy and tumor recurrence. (PubMed id 21533858)1 Huang P....Kumon H. (2012)
    76. Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145. (PubMed id 22378186)1 Jia Y....Zhang W. (2012)
    77. Acquired cancer stem cell phenotypes through Oct4-medi ated dedifferentiation. (PubMed id 22286766)1 Kumar S.M....Xu X. (2012)
    78. Oct4 and Sox2 are overexpressed in human neuroblastoma and inhibited by chemotherapy. (PubMed id 22576801)1 Yang S....Xiao X. (2012)
    79. Oct-3/4 promotes migration and invasion of glioblastom a cells. (PubMed id 21938739)1 Kobayashi K....Tanaka J. (2012)
    80. Expression of OCT4 in human esophageal squamous cell c arcinoma is significantly associated with poorer prognosis. (PubMed id 22363145)1 He W....Fan Q.X. (2012)
    81. The novel function of OCT4B isoform-265 in genotoxic s tress. (PubMed id 22247013)1 Gao Y....Dai J. (2012)
    82. Canine fibroblasts expressing human transcription fact ors: what is in the route for the production of canine induced pluripotent stem cells. (PubMed id 23279472)1 Goncalves N.J....Ambrosio C.E. (2012)
    83. Co-expression of Oct-4 and Nestin in human breast canc ers. (PubMed id 22207173)1 Liu C....Jin F. (2012)
    84. Expression of OCT3/4 in renal medullary carcinoma represents a potential diagnostic pitfall. (PubMed id 22301499)1 Rao P....Tamboli P. (2012)
    85. Clinicopathological significance of non-small cell lun g cancer with high prevalence of Oct-4 tumor cells. (PubMed id 22300949)1 Chen Z....Xiang A.P. (2012)
    86. Expression analysis of stem cell-related genes reveal OCT4 as a predictor of poor clinical outcome in medulloblastoma. (PubMed id 21725800)1 Rodini C.O....Okamoto O.K. (2012)
    87. Comparative epigenetic analysis of Oct4 regulatory reg ion in RA-induced differentiated NT2 cells under adherent and non-adherent cultu re conditions. (PubMed id 22160855)1 Favaedi R....Akhoond M.R. (2012)
    88. [Expression of OCT4 protein in bladder cancer and its clinicopathological implications]. (PubMed id 22588915)1 Zhao P....Huang P. (2012)
    89. OCT4 spliced variant OCT4B1 is expressed in human col orectal cancer. (PubMed id 21480394)1 Gazouli M....Anagnou N.P. (2012)
    90. CD49f enhances multipotency and maintains stemness thr ough the direct regulation of OCT4 and SOX2. (PubMed id 22311737)1 Yu K.R....Kang K.S. (2012)
    91. Role of the stemness factors sox2, oct3/4, and nanog i n gastric carcinoma. (PubMed id 21227461)1 Matsuoka J....Hirakawa K. (2012)
    92. Regulation of OCT4 gene expression by liver receptor h omolog-1 in human embryonic carcinoma cells. (PubMed id 23000165)1 Sung B....Kim J.H. (2012)
    93. Inhibition of LDH-A by lentivirus-mediated small inter fering RNA suppresses intestinal-type gastric cancer tumorigenicity through the downregulation of Oct4. (PubMed id 22429998)1 Zhang Y....Qin S. (2012)
    94. Increased expression of OCT4 is associated with low di fferentiation and tumor recurrence in human hepatocellular carcinoma. (PubMed id 22824146)1 Dong Z....Liu L. (2012)
    95. Hypoxia modulates the undifferentiated phenotype of h uman renal inner medullary CD133+ progenitors through Oct4/miR-145 balance. (PubMed id 21900452)1 Bussolati B....Camussi G. (2012)
    96. Oct4 and Nanog directly regulate Dnmt1 to maintain sel f-renewal and undifferentiated state in mesenchymal stem cells. (PubMed id 22795133)1 Tsai C.C....Hung S.C. (2012)
    97. Diagnostic utility of CD117, CD133, SALL4, OCT4, TCL1 and glypican-3 in malignant germ cell tumors of the ovary. (PubMed id 22448662)1 Trinh D.T....Kikkawa F. (2012)
    98. Transcriptome and network changes in climbers at extre me altitudes. (PubMed id 22393366)1 Chen F....Wang J. (2012)
    99. A plausible anti-apoptotic role of up-regulated OCT4B1 in bladder tumors. (PubMed id 22903480)1 Asadzadeh J....Mowla S.J. (2012)
    100. Dental pulp stem cells differentiation reveals new ins ights in Oct4A dynamics. (PubMed id 22844522)1 Ferro F....Curcio F. (2012)
    101. Identification of Oct4-activating compounds that enhan ce reprogramming efficiency. (PubMed id 23213213)1 Li W....Shi Y. (2012)
    102. p28(GANK) prevents degradation of Oct4 and promotes ex pansion of tumor-initiating cells in hepatocarcinogenesis. (PubMed id 22387393)1 Qian Y.W....Wang H.Y. (2012)
    103. Generation of induced pluripotent stem cells from huma n renal proximal tubular cells with only two transcription factors, OCT4 and SOX 2. (PubMed id 22613719)1 Montserrat N....Campistol J.M. (2012)
    104. Methylation profile of the promoters of Nanog and Oct4 in ICSI human embryos. (PubMed id 22914767)1 Al-Khtib M....Lefevre A. (2012)
    105. Chemotherapeutic sensitivity of testicular germ cell t umors under hypoxic conditions is negatively regulated by SENP1-controlled sumoy lation of OCT4. (PubMed id 23002208)1 Wu Y.C....Huang Y.H. (2012)
    106. OCT4 positively regulates Survivin expression to promo te cancer cell proliferation and leads to poor prognosis in esophageal squamous cell carcinoma. (PubMed id 23185410)1 Li C....Su C. (2012)
    107. Upregulation and inhibition of the nuclear translocati on of Oct4 during multistep gastric carcinogenesis. (PubMed id 22922943)1 Al-Marzoqee F.Y....Karam S.M. (2012)
    108. Wnt/b-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4. (PubMed id 22392999)1 Davidson K.C....Moon R.T. (2012)
    109. Co-localization of NANOG and OCT4 in human pre-implant ation embryos and in human embryonic stem cells. (PubMed id 22743827)1 Hambiliki F....Stavreus-Evers A. (2012)
    110. Hyaluronan-CD44v3 interaction with Oct4-Sox2-Nanog pro motes miR-302 expression leading to self-renewal, clonal formation, and cisplati n resistance in cancer stem cells from head and neck squamous cell carcinoma. (PubMed id 22847005)1 Bourguignon L.Y....Chen L. (2012)
    111. Synergistic effect of SCF and G-CSF on stem-like prope rties in prostate cancer cell lines. (PubMed id 22252524)1 Ma Y....Suo Z. (2012)
    112. Squelching of ETS2 transactivation by POU5F1 silences the human chorionic gonadotropin CGA subunit gene in human choriocarcinoma and e mbryonic stem cells. (PubMed id 22446105)1 Gupta R....Roberts R.M. (2012)
    113. Protein markers of cancer-associated fibroblasts and t umor-initiating cells reveal subpopulations in freshly isolated ovarian cancer a scites. (PubMed id 22901285)1 Wintzell M....Shoshan M. (2012)
    114. Genetic variations in stem cell-related genes and colo rectal cancer prognosis. (PubMed id 22528324)1 Yang H....Xing J. (2012)
    115. Hypoxia induces CD133 expression in human lung cancer cells by up-regulation of OCT3/4 and SOX2. (PubMed id 21947321)1 Iida H....Ueno H. (2012)
    116. Isolation and characterization of mesenchymal stem cel ls from whole human umbilical cord applying a single enzyme approach. (PubMed id 22777760)1 Zhang H....Chen H. (2012)
    117. Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells. (PubMed id 22482508)1 Wang Z....Ivanova N. (2012)
    118. Transcriptional activation by Oct4 is sufficient for t he maintenance and induction of pluripotency. (PubMed id 22832160)1 Hammachi F....Brickman J.M. (2012)
    119. Meiotic competent human germ cell-like cells derived f rom human embryonic stem cells induced by BMP4/WNT3A signaling and OCT4/EpCAM (e pithelial cell adhesion molecule) selection. (PubMed id 22396540)1 Chuang C.Y....Kuo H.C. (2012)
    120. Reciprocal regulation of Akt and Oct4 promotes the sel f-renewal and survival of embryonal carcinoma cells. (PubMed id 23041284)1 Lin Y....Wang Y.J. (2012)
    121. Up-regulation of microRNA-145 promotes differentiatio n by repressing OCT4 in human endometrial adenocarcinoma cells. (PubMed id 21365617)1 Wu Y....Wang H. (2011)
    122. Activation of the aryl hydrocarbon receptor AhR Promo tes retinoic acid-induced differentiation of myeloblastic leukemia cells by res tricting expression of the stem cell transcription factor Oct4. (PubMed id 21262915)1 Bunaciu R.P. and Yen A. (2011)
    123. Transcriptional regulation of oct4 in human bone marr ow mesenchymal stem cells. (PubMed id 20594032)1 Wei X. and Shen C.Y. (2011)
    124. Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosoma haematobium infection. (PubMed id 21951846)1 Ma N....Kawanishi S. (2011)
    125. Expression and interdependencies of pluripotency fact ors LIN28, OCT3/4, NANOG and SOX2 in human testicular germ cells and tumours of the testis. (PubMed id 21631526)1 Gillis A.J....Looijenga L.H. (2011)
    126. New candidate gene POU5F1 associated with premature o varian failure in Chinese patients. (PubMed id 21273125)1 Wang J....Cao Y. (2011)
    127. A case-control study on the rs3130932 single nucleoti de polymorphism in the OCT4B translation initiation codon in association with c ancer state. (PubMed id 21301344)1 Katafigiotis S....Lambropoulos A.F. (2011)
    128. Downregulation of transcription factor Oct4 induces a n epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells. (PubMed id 21798248)1 Hu J....Tan X. (2011)
    129. Genome-wide analysis of OCT4 binding sites in gliobla stoma cancer cells. (PubMed id 21960344)1 Fang X.F....Lin B.Y. (2011)
    130. [Expressions of OCT4 and CD133 and their correlation i n colonic cancer]. (PubMed id 21868340)1 Chen W.S....Li W.D. (2011)
    131. Oct4-related cytokine effects regulate tumorigenic pr operties of colorectal cancer cells. (PubMed id 22037460)1 Chang C.J....Lan Y.T. (2011)
    132. microRNA-145 suppresses lung adenocarcinoma-initiatin g cell proliferation by targeting OCT4. (PubMed id 21479367)1 Yin R....Xu L. (2011)
    133. A regulatory circuitry comprised of miR-302 and the t ranscription factors OCT4 and NR2F2 regulates human embryonic stem cell differe ntiation. (PubMed id 21151097)1 Rosa A. and Brivanlou A.H. (2011)
    134. A DNA repair complex functions as an Oct4/Sox2 coacti vator in embryonic stem cells. (PubMed id 21962512)1 Fong Y.W....Tjian R. (2011)
    135. Glioma-initiating cells retain their tumorigenicity t hrough integration of the Sox axis and Oct4 protein. (PubMed id 21987575)1 Ikushima H....Miyazono K. (2011)
    136. FOXO1 is an essential regulator of pluripotency in hu man embryonic stem cells. (PubMed id 21804543)1 Zhang X....Ghaffari S. (2011)
    137. Role of Sox2 and Oct4 in predicting survival of hepat ocellular carcinoma patients after hepatectomy. (PubMed id 21376027)1 Huang P....Yuan Y. (2011)
    138. OCT4 establishes and maintains nucleosome-depleted re gions that provide additional layers of epigenetic regulation of its target gen es. (PubMed id 21844352)1 You J.S....Jones P.A. (2011)
    139. [miR-145 inhibits lung adenocarcinoma stem cells prol iferation by targeting OCT4 gene]. (PubMed id 21496429)1 Zhang S....Xu L. (2011)
    140. Nuclear orphan receptor TLX induces Oct-3/4 for the s urvival and maintenance of adult hippocampal progenitors upon hypoxia. (PubMed id 21135096)1 Chavali P.L....Funa K. (2011)
    141. Clinical implications of stem cell gene Oct-4 express ion in breast cancer. (PubMed id 21394007)1 Liu C.G....Lu P. (2011)
    142. Undifferentiated gonadal tissue, Y chromosome instabil ity, and tumors in XY gonadal dysgenesis. (PubMed id 21692598)1 Beaulieu Bergeron M....Brochu P. (2011)
    143. Pluripotency regulators in human mesenchymal stem cel ls: expression of NANOG but not of OCT-4 and SOX-2. (PubMed id 20879854)1 Pierantozzi E....Sorrentino V. (2011)
    144. [Small interfering RNA-mediated OCT4 gene silencing in hibits the proliferation and induces apoptosis of pancreatic cancer cell line PA NC1]. (PubMed id 21602143)1 Huang J.Q. (2011)
    145. Pluripotency-associated stem cell marker expression i n proliferative cell cultures derived from adult human pancreas. (PubMed id 21852325)1 White M.G....Shaw J.A. (2011)
    146. Transient expression of OCT4 is sufficient to allow h uman keratinocytes to change their differentiation pathway. (PubMed id 20981110)1 Racila D....Bickenbach J.R. (2011)
    147. [Expression of Oct-4 transcription factor in squamous cell skin carcinoma and seborrheic keratosis]. (PubMed id 21602158)1 Li Y.Y....Chen H.F. (2011)
    148. Over-expression of Oct4 in human esophageal squamous cell carcinoma. (PubMed id 21547540)1 Zhou X....Hu P. (2011)
    149. Nocodazole treatment decreases expression of pluripot ency markers Nanog and Oct4 in human embryonic stem cells. (PubMed id 21559451)1 Kallas A....Maimets T. (2011)
    150. [Altered expressions of embryonic stem-related genes i n pancreatic cancer stem cell]. (PubMed id 22340650)1 Lu Y.H....Zhu M.Y. (2011)
    151. Expression pattern of Oct-4, Sox2, and c-Myc in the p rimary culture of human dental pulp derived cells. (PubMed id 21419292)1 Liu L....Xiao Y. (2011)
    152. [Correlation between expression of HIF-2a and OCT-4 an d prognosis of NSCLC]. (PubMed id 21946204)1 Wei L....Hu C. (2011)
    153. Differential expression of Oct4 in HPV-positive and H PV-negative cervical cancer cells is not regulated by DNA methyltransferase 3A. (PubMed id 21674242)1 Liu D....He F. (2011)
    154. Oct-4+/Tenascin C+ neuroblastoma cells serve as proge nitors of tumor-derived endothelial cells. (PubMed id 21403679)1 Pezzolo A....Pistoia V. (2011)
    155. Expression profile of embryonic stem cell-associated g enes Oct4, Sox2 and Nanog in human gliomas. (PubMed id 22014056)1 Guo Y....Hao A. (2011)
    156. Histone methylation is a critical regulator of the ab normal expression of POU5F1 and RASSF1A in testis cancer cell lines. (PubMed id 20497257)1 Lambrot R. and Kimmins S. (2011)
    157. Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. (PubMed id 21477851)1 Ang Y.S....Lemischka I.R. (2011)
    158. OCT4B1, a novel spliced variant of OCT4, is highly ex pressed in gastric cancer and acts as an antiapoptotic factor. (PubMed id 20824712)1 Asadi M.H....Atlasi Y. (2011)
    159. OCT4B1, a novel spliced variant of OCT4, generates a stable truncated protein with a potential role in stress response. (PubMed id 21684074)1 Farashahi Yazd E....Mowla S.J. (2011)
    160. Oct-4B isoform is differentially expressed in breast cancer cells: hypermethylation of regulatory elements of Oct-4A suggests an alt ernative promoter and transcriptional start site for Oct-4B transcription. (PubMed id 20433421)1 Wang Y....Lin A. (2011)
    161. Oct4 expression in immature teratoma of the ovary: re levance to histologic grade and degree of differentiation. (PubMed id 21107090)1 Abiko K....Konishi I. (2010)
    162. Human corneal basal epithelial cells express an embry onic stem cell marker OCT4. (PubMed id 20958186)1 Zhou S.Y....Chuck R.S. (2010)
    163. A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4. (PubMed id 20477760)1 Smith J.A....Daniel R. (2010)
    164. Prognostic significance of Oct4 and Sox2 expression i n hypopharyngeal squamous cell carcinoma. (PubMed id 20937145)1 Ge N....Kang T. (2010)
    165. [Significance of Oct-4's expression in thyroid neopla sm]. (PubMed id 20942235)1 Wang H. and Wang J. (2010)
    166. Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelia l-mesenchymal transdifferentiation. (PubMed id 21159654)1 Chiou S.H....Wu C.W. (2010)
    167. Side population increase after simulated transient is chemia in human dental pulp cell. (PubMed id 20171362)1 Wang J....Gong Q. (2010)
    168. Function of EWS-POU5F1 in sarcomagenesis and tumor ce ll maintenance. (PubMed id 20203285)1 Fujino T....Nakamura T. (2010)
    169. Interaction of organic cation transporter 3 (SLC22A3) and amphetamine. (PubMed id 20402963)7 Zhu H.J....Markowitz J.S. (2010)
    170. A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells. (PubMed id 20505756)1 Jung M....Adjaye J. (2010)
    171. OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome. (PubMed id 20347080)1 Bianco B....Verreschi I.T. (2010)
    172. Prognostic significance of OCT4 expression in adenoca rcinoma of the lung. (PubMed id 20462980)1 Zhang X....Dong Q. (2010)
    173. Natural immunity to pluripotency antigen OCT4 in huma ns. (PubMed id 20404147)1 Dhodapkar K.M....Dhodapkar M.V. (2010)
    174. Human haematopoietic stem cells express Oct4 pseudoge nes and lack the ability to initiate Oct4 promoter-driven gene expression. (PubMed id 20356403)1 Redshaw Z. and Strain A.J. (2010)
    175. Oct4 and Nanog expression is associated with early st ages of pancreatic carcinogenesis. (PubMed id 20173672)1 Wen J....Song S.Y. (2010)
    176. Mapping of the minimal internal ribosome entry site e lement in the human embryonic stem cell gene OCT4B mRNA. (PubMed id 20230781)1 Zhang W....Dai J. (2010)
    177. Expression profile of the embryonic markers nanog, OC T-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mese nchymal stem cells. (PubMed id 20458727)1 Trubiani O....Nanci A. (2010)
    178. Concise review: isoforms of OCT4 contribute to the co nfusing diversity in stem cell biology. (PubMed id 20333750)1 Wang X. and Dai J. (2010)
    179. [OCT4 expression in hepatocellular carcinoma and its clinical significance] (PubMed id 20038322)1 Huang P.Z....Yuan Y.F. (2010)
    180. TIF1beta regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner. (PubMed id 20508149)1 Seki Y....Asashima M. (2010)
    181. Comparative study of stemness characteristics of mese nchymal cells from bone marrow of children and adults. (PubMed id 20662612)1 Choumerianou D.M....Dimitriou H. (2010)
    182. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with BehAset's disea se. (PubMed id 20622878)4 Remmers E.F....GA1l A. (2010)
    183. The expression of stem cell-related indicators as a p rognostic factor in human lung adenocarcinoma. (PubMed id 20818602)1 Zhang X.Y....Han B.H. (2010)
    184. Phosphorylated nucleolin interacts with translational ly controlled tumor protein during mitosis and with Oct4 during interphase in E S cells. (PubMed id 21048921)1 Johansson H....Simonsson S. (2010)
    185. Lin28-mediated post-transcriptional regulation of Oct 4 expression in human embryonic stem cells. (PubMed id 19966271)1 Qiu C....Huang Y. (2010)
    186. A novel SALL4/OCT4 transcriptional feedback network f or pluripotency of embryonic stem cells. (PubMed id 20505821)1 Yang J....Ma Y. (2010)
    187. Rapid and efficient reprogramming of human amnion-der ived cells into pluripotency by three factors OCT4/SOX2/NANOG. (PubMed id 20510497)1 Zhao H.X....Wang X.H. (2010)
    188. Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3. (PubMed id 20858707)1 Duan H. and Wang J. (2010)
    189. OCT-4 expression in follicular and luteal phase endom etrium: a pilot study. (PubMed id 20412569)1 Bentz E.K....Tempfer C.B. (2010)
    190. Wnt/beta-catenin signaling regulates cancer stem cell s in lung cancer A549 cells. (PubMed id 20074550)1 Teng Y....Ma D. (2010)
    191. Oct-3/4 regulates stem cell identity and cell fate de cisions by modulating Wnt/I^-catenin signalling. (PubMed id 20736927)1 Abu-Remaileh M....Bergman Y. (2010)
    192. OCT4 and downstream factors are expressed in human so matic urogenital epithelia and in culture of epididymal spheres. (PubMed id 20123703)1 Kristensen D.M....Leffers H. (2010)
    193. Generation of human-induced pluripotent stem cells fr om gut mesentery-derived cells by ectopic expression of OCT4/SOX2/NANOG. (PubMed id 20698766)1 Li Y....Li L. (2010)
    194. Single-molecule analysis reveals changes in the DNA r eplication program for the POU5F1 locus upon human embryonic stem cell differen tiation. (PubMed id 20647538)1 Schultz S.S....Schildkraut C.L. (2010)
    195. Comparison of MHC class I risk haplotypes in Thai and Caucasian psoriatics shows locus heterogeneity at PSORS1. (PubMed id 20604894)2 Stuart P.E....Elder J.T. (2010)
    196. [The dual role of OCT4] (PubMed id 20412747)1 Stefanovic S. and PucAcat M. (2010)
    197. Transcriptional regulation of Oct4 by a long non-codi ng RNA antisense to Oct4-pseudogene 5. (PubMed id 21151833)1 Hawkins P.G. and Morris K.V. (2010)
    198. Newer insights into premeiotic development of germ ce lls in adult human testis using Oct-4 as a stem cell marker. (PubMed id 20805580)1 Bhartiya D....Tongaonkar H.B. (2010)
    199. Ascorbic acid induces in vitro proliferation of human subcutaneous adipose tissue derived mesenchymal stem cells with upregulation o f embryonic stem cell pluripotency markers Oct4 and SOX 2. (PubMed id 21166886)1 Potdar P.D. and D'Souza S.B. (2010)
    200. A protocol describing the genetic correction of somat ic human cells and subsequent generation of iPS cells. (PubMed id 20224565)1 Raya A....IzpisA_a Belmonte J.C. (2010)
    201. Human embryonic stem cells from aneuploid blastocysts identified by pre-implantation genetic screening. (PubMed id 20224970)1 Narwani K....Lavon N. (2010)
    202. Atypical expression and distribution of embryonic ste m cell marker, OCT4, in human lung adenocarcinoma. (PubMed id 20721963)1 Karoubi G....Schmid R.A. (2010)
    203. Novel candidate cancer genes identified by a large-sc ale cross-species comparative oncogenomics approach. (PubMed id 20103622)1 Mattison J....Adams D.J. (2010)
    204. Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)
    205. Oct4, a novel marker for human gastric cancer. (PubMed id 19347886)1 Chen Z....Xu X.J. (2009)
    206. OCT4A contributes to the stemness and multi-potency of human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs). (PubMed id 19394308)1 Seo K.W....Kang K.S. (2009)
    207. Alternative translation of OCT4 by an internal riboso me entry site and its novel function in stress response. (PubMed id 19489092)1 Wang X....Dai J. (2009)
    208. Mutation in the DNA-binding domain of the EWS-Oct-4 oncogene results in dominant negative activity that interferes with EWS-Oct-4-mediated transactivation. (PubMed id 19170206)1 Kim S....Kim J. (2009)
    209. Mesenchymal to embryonic incomplete transition of hum an cells by chimeric OCT4/3 (POU5F1) with physiological co-activator EWS. (PubMed id 19559696)1 Makino H....Umezawa A. (2009)
    210. A method for isolating pluripotent/multipotent stem c ells from blood by using the pluripotent and germ-line DAZL gene as a marker. (PubMed id 19327014)1 Seligman J....Fabian I. (2009)
    211. Oct4A is expressed by a subpopulation of prostate neuroendocrine cells. (PubMed id 19058139)1 Sotomayor P....Huss W.J. (2009)
    212. Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells. (PubMed id 19528230)1 Sun C....Yokota T. (2009)
    213. Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy. (PubMed id 19657699)1 Saigusa S....Kusunoki M. (2009)
    214. Genes involved in regulation of stem cell properties: studies on their expression in a small cohort of neuroblastoma patients. (PubMed id 19458492)1 Melone M.A....Galderisi U. (2009)
    215. Embryonic stem cell transcription factors and D2-40 ( podoplanin) as diagnostic immunohistochemical markers in ovarian germ cell tumo rs. (PubMed id 19483629)1 Chang M.C....Nucci M.R. (2009)
    216. A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. (PubMed id 19171782)1 Kang J....Tantin D. (2009)
    217. Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. (PubMed id 19816951)1 Wei Z....Lu W. (2009)
    218. OCT4 expression in human non-small cell lung cancer: implications for therapeutic intervention. (PubMed id 19126554)1 Karoubi G....Dutly A. (2009)
    219. Specific knockdown of OCT4 in human embryonic stem ce lls by inducible short hairpin RNA interference. (PubMed id 19350677)1 Zafarana G....Andrews P.W. (2009)
    220. Analysis of OCT4 expression in an extended panel of human tumor cell lines from multiple entities and in human mesenchymal stem cells. (PubMed id 19023518)1 Mueller T....Mueller L.P. (2009)
    221. Implication of human OCT4 transactivation domains for self-regulatory transcription. (PubMed id 19445899)1 Lim H.Y....Kim J.H. (2009)
    222. The expression of pluripotency marker Oct 3/4 in pros tate cancer and benign prostate hyperplasia. (PubMed id 19274762)1 Monsef N....Panagopoulos I. (2009)
    223. Oct3/4 and Sox2 are significantly associated with an unfavorable clinical outcome in human esophageal squamous cell carcinoma. (PubMed id 19414369)1 Wang Q....Suo Z. (2009)
    224. Oct-4A isoform is expressed in human cord blood-deriv ed CD133 stem cells and differentiated progeny. (PubMed id 19438894)1 Howe M....Denner L. (2009)
    225. iPS programmed without c-MYC yield proficient cardiog enesis for functional heart chimerism. (PubMed id 19696409)1 Martinez-Fernandez A....Terzic A. (2009)
    226. Involvement of the organic cation transporters in his tamine uptake into human vascular endothelial cells. (PubMed id 19271143)1 Cerne K. and Krzan M. (2009)
    227. Testicular mixed germ cell tumors: a morphological an d immunohistochemical study using stem cell markers, OCT3/4, SOX2 and GDF3, wit h emphasis on morphologically difficult-to-classify areas. (PubMed id 19396148)1 Gopalan A....Tickoo S.K. (2009)
    228. BMP-11 and myostatin support undifferentiated growth of human embryonic stem cells in feeder-free cultures. (PubMed id 19751112)1 Hannan N.R....Wolvetang E.J. (2009)
    229. O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development. (PubMed id 19383152)1 Webster D.M....Dougan S.T. (2009)
    230. Eset partners with Oct4 to restrict extraembryonic tr ophoblast lineage potential in embryonic stem cells. (PubMed id 19884257)1 Yuan P....Ng H.H. (2009)
    231. Role of Oct-4 during acquisition of developmental com petence in mouse oocyte. (PubMed id 20034424)1 Zuccotti M....Garagna S. (2009)
    232. Regulation of adipose tissue stromal cells behaviors by endogenic Oct4 expression control. (PubMed id 19777066)1 Kim J.H....Kang S.K. (2009)
    233. Interplay of Oct4 with Sox2 and Sox17: a molecular sw itch from stem cell pluripotency to specifying a cardiac fate. (PubMed id 19736317)1 Stefanovic S....PucAcat M. (2009)
    234. Expression of transcription factor Oct4 in bladder ca ncer cell line T24 and its effects on the biological characteristics of the cel ls. (PubMed id 19224167)1 Zhu Z....Fan C. (2009)
    235. MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. (PubMed id 19409607)1 Xu N....Kosik K.S. (2009)
    236. Oct4 is epigenetically regulated by methylation in normal placenta and gestational trophoblastic disease. (PubMed id 18440631)1 Zhang H.J....Cheung A.N. (2008)
    237. Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. (PubMed id 18710938)1 Card D.A....Archer T.K. (2008)
    238. In vivo osteoprogenitor potency of human stromal cells from different tissues does not correlate with expression of POU5F1 or its pseudogenes. (PubMed id 18617685)1 Kaltz N....Oostendorp R.A. (2008)
    239. Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells. (PubMed id 18676852)1 Chang C.C....Wu C.L. (2008)
    240. Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. (PubMed id 18281244)1 Kristensen D.M....Leffers H. (2008)
    241. Identification of DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays. (PubMed id 18366076)1 Chakravarthy H....Rizzino A. (2008)
    242. OCT4 spliced variants are differentially expressed in human pluripotent and nonpluripotent cells. (PubMed id 18787205)1 Atlasi Y....Andrews P.W. (2008)
    243. The early human germ cell lineage does not express SOX2 during in vivo development or upon in vitro culture. (PubMed id 18199879)1 Perrett R.M....Hanley N.A. (2008)
    244. Absence of OCT4 expression in somatic tumor cell lines. (PubMed id 18032701)1 Cantz T....Scholer H.R. (2008)
    245. Participation of OCT3/4 and beta-catenin during dysgenetic gonadal malignant transformation. (PubMed id 18295396)1 Palma I....Queipo G. (2008)
    246. Differential expression of the embryo/cancer gene ECSA(DPPA2), the cancer/testis gene BORIS and the pluripotency structural gene OCT4, in human preimplantation development. (PubMed id 18467432)1 Monk M....Hawes S. (2008)
    247. [Identification of the OCT4-pg1 retrogene and NANOG gene expression in the human embryonic eye] (PubMed id 18946985)1 Firsova N.V....Mitashov V.I. (2008)
    248. The transcription factor Zfp281 controls embryonic st em cell pluripotency by direct activation and repression of target genes. (PubMed id 18757296)1 Wang Z.X....Stanton L.W. (2008)
    249. Genome-wide analysis reveals Sall4 to be a major regu lator of pluripotency in murine-embryonic stem cells. (PubMed id 19060217)1 Yang J....Ma Y. (2008)
    250. Simultaneous expression of Oct4 and genes of three germ layers in single cell-derived multipotent adult progenitor cells. (PubMed id 18338169)1 Ji K.H....Liu H.Q. (2008)
    251. Identification of karyopherin-alpha 2 as an Oct4 associated protein. (PubMed id 19103427)1 Li X....Jin Y. (2008)
    252. Sequence variation in the human transcription factor gene POU5F1. (PubMed id 18254969)1 Hussain S.K....Schwartz S.M. (2008)
    253. Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. (PubMed id 18957414)1 Zhang X....Pei D. (2008)
    254. Novel variants of Oct-3/4 gene expressed in mouse somatic cells. (PubMed id 18765667)1 Mizuno N. and Kosaka M. (2008)
    255. Reprogramming of human somatic cells to pluripotency with defined factors. (PubMed id 18157115)1 Park I.H....Daley G.Q. (2008)
    256. Differentiation of human embryonic stem cells induces condensation of chromosome territories and formation of heterochromatin protein 1 foci. (PubMed id 17573914)1 Bartova E....Kozubek S. (2008)
    257. Epigenetic deregulation of the human Oct4 promoter in mouse cells. (PubMed id 18810488)1 Cha Y....Park K.S. (2008)
    258. Polycomb group proteins Ring1A/B are functionally lin ked to the core transcriptional regulatory circuitry to maintain ES cell identi ty. (PubMed id 18339675)1 Endoh M....Koseki H. (2008)
    259. Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs. (PubMed id 17390031)1 Katoh M. and Katoh M. (2007)
    260. Functional similarities among genes regulated by OCT4 in human mesenchymal and embryonic stem cells. (PubMed id 17761754)1 Greco S.J....Rameshwar P. (2007)
    261. Risk alleles for multiple sclerosis identified by a genomewide study. (PubMed id 17660530)4  ....Hauser S.L. (2007)
    262. A novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung. (PubMed id 17923501)1 Chen Y....Lin C.L. (2007)
    263. Differential methylation of the OCT3/4 upstream region in primary human testicular germ cell tumors. (PubMed id 17549357)1 De Jong J....Looijenga L.H. (2007)
    264. Expression and significance of Oct4 in bladder cancer . (PubMed id 18231740)1 Xu K....Zeng F. (2007)
    265. Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis? (PubMed id 17413979)1 Howell N.R....Liang S.X. (2007)
    266. Manipulation of OCT4 levels in human embryonic stem cells results in induction of differential cell types. (PubMed id 17959850)1 Rodriguez R.T....Firpo M.T. (2007)
    267. Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. (PubMed id 17982423)1 McGowan S.L....Whikehart D.R. (2007)
    268. Oct-3/4: not just a gatekeeper of pluripotency for embryonic stem cell, a cell fate instructor through a gene dosage effect. (PubMed id 17245123)1 Stefanovic S. and Puceat M. (2007)
    269. Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. (PubMed id 17273778)1 Katoh Y. and Katoh M. (2007)
    270. The genetic polymorphisms of POU5F1 gene are associated with psoriasis vulgaris in Chinese. (PubMed id 17314032)1 Chang Y.T....Tsai S.F. (2007)
    271. Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells. (PubMed id 17068183)1 Babaie Y....Adjaye J. (2007)
    272. Morphological and molecular characterization of novel population of CXCR4+ SSEA-4+ Oct-4+ very small embryonic-like cells purified from human cord blood: preliminary report. (PubMed id 17136117)1 Kucia M....Ratajczak M.Z. (2007)
    273. Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal. (PubMed id 17506876)1 Greber B....Adjaye J. (2007)
    274. The human OCT-4 isoforms differ in their ability to confer self-renewal. (PubMed id 16951404)1 Lee J....Kim J. (2006)
    275. Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro. (PubMed id 16892178)1 Baharvand H....Farrokhi A. (2006)
    276. Molecular mechanisms of coupled monoubiquitination. (PubMed id 17013377)1 Woelk T....Polo S. (2006)
    277. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. (PubMed id 16582099)1 Wissmuller S....Wegner M. (2006)
    278. Isolation and characterization of a population of immature dental pulp stem cells expressing OCT-4 and other embryonic stem cell markers. (PubMed id 17409736)1 Kerkis I....Cerruti H.F. (2006)
    279. Loss of Oct-3/4 expression in embryonal carcinoma cells is associated with induction of cisplatin resistance. (PubMed id 16557044)1 Mueller T....Schmoll H.J. (2006)
    280. EWSR1 is fused to POU5F1 in a bone tumor with translo cation t(6;22)(p21;q12). (PubMed id 15729702)1 Yamaguchi S....Nakamura T. (2005)
    281. Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro. (PubMed id 15790780)1 Moriscot C....Benhamou P.Y. (2005)
    282. Oct-4 mRNA and protein expression during human preimplantation development. (PubMed id 15695770)1 Cauffman G....Van Steirteghem A. (2005)
    283. Stably transfected human embryonic stem cell clones express OCT4-specific green fluorescent protein and maintain self-renewal and pluripotency. (PubMed id 15625129)1 Gerrard L....Cui W. (2005)
    284. High-efficiency RNA interference in human embryonic stem cells. (PubMed id 15749924)1 Zaehres H....Daley G.Q. (2005)
    285. Expression of transcription factor Oct-4 and other embryonic genes in CD133 positive cells from human umbilical cord blood. (PubMed id 15467907)1 Baal N....Zygmunt M.T. (2004)
    286. Wwp2, an E3 ubiquitin ligase that targets transcripti on factor Oct-4 for ubiquitination. (PubMed id 15047715)1 Xu H.M....Jin Y. (2004)
    287. Developmental expression of POU5F1 (OCT-3/4) in normal and dysgenetic human gonads. (PubMed id 15105401)1 Rajpert-De Meyts E....Skakkebaek N.E. (2004)
    288. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    289. POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. (PubMed id 12727846)1 Looijenga L.H....Oosterhuis J.W. (2003)
    290. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    291. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    292. Oct-1 preferentially interacts with androgen receptor in a DNA-dependent manner that facilitates recruitment of SRC-1. (PubMed id 11096094)1 Gonzalez M.I. and Robins D.M. (2001)
    293. Phage display screening reveals an association between germline-specific transcription factor Oct-4 and multiple cellular proteins. (PubMed id 11099378)1 Butteroni C....Pesce M. (2000)
    294. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. (PubMed id 9814708)1 Nichols J....Smith A. (1998)
    295. The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors. (PubMed id 9368058)1 Inamoto S....Roeder R.G. (1997)
    296. Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1 Hillier L.D....Marra M. (1996)
    297. Localization of the OTF3 gene within the human MHC class I region by physical and meiotic mapping. (PubMed id 8088794)1 Crouau-Roy B....Pontarotti P. (1994)
    298. A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. (PubMed id 7908264)2 Wey E.... Schaefer B.W. (1994)
    299. In situ hybridization localizes the human OTF3 to chromosome 6p21.3-->p22 and OTF3L to 12p13. (PubMed id 8500351)1 Guillaudeux T....Pontarotti P. (1993)
    300. Octamer-dependent regulation of the kFGF gene in embryonal carcinoma and embryonic stem cells. (PubMed id 1723621)1 Schoorlemmer J. and Kruijer W. (1991)
    301. (PubMed id 18035408)2 
    302. OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. (PubMed id 15725806)9 Hattab E.M....Cheng L. (2005)
    303. Promoter analysis of the rabbit POU5F1 gene and its e xpression in preimplantation stage embryos. (PubMed id 19732419)9 Kobolak J....Dinnyes A. (2009)
    304. Dynamic epigenetic regulation of the Oct4 and Nanog r egulatory regions during neural differentiation in rhesus nuclear transfer embr yonic stem cells. (PubMed id 20025521)9 Wang K....Cibelli J.B. (2009)
    305. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. (PubMed id 15988017)9 Chew J.L....Ng H.H. (2005)
    306. Regulation of Oct-4 gene expression during differentiation of EC cells. (PubMed id 8832901)9 Schoorlemmer J....Kruijer W. (1995)
    307. Revisiting OCT4 expression in peripheral blood mononuclear cells. (PubMed id 17932416)9 Kotoula V....Lambropoulos A.F. (2008)
    308. Use of altered-specificity binding Oct-4 suggests an absence of pluripotent cell-specific cofactor usage. (PubMed id 16243786)9 Smith A.E. and Ford K.G. (2005)
    309. Oct4 expression revisited: potential pitfalls for data misinterpretation in stem cell research. (PubMed id 18627312)9 Liedtke S....Kogler G. (2008)
    310. Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis. (PubMed id 18701476)9 Hu T....Sun S. (2008)
    311. [Expression and significance of prostate stem cell antigen and Oct-4 in benign and malignant lesions of the stomach] (PubMed id 18667777)9 Yao H.L....Li Y.G. (2008)
    312. A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. (PubMed id 16790525)9 Pan G....Pei D. (2006)
    313. Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells. (PubMed id 14990861)9 Hay D.C....Burdon T. (2004)
    314. Analysis of Oct-4 expression and ploidy in individual human blastomeres. (PubMed id 11160841)9 Hansis C....Krey L.C. (2001)
    315. Identification of putative downstream genes of Oct-4 by suppression-subtractive hybridization. (PubMed id 11401518)9 Du Z....Yao Z. (2001)
    316. Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the fibroblast growth factor-4 enhancer. (PubMed id 10801796)9 Ambrosetti D.C....Basilico C. (2000)
    317. Transcriptional activation by Oct-3: evidence for a specific role of the POU-specific domain in mediating functional interaction with Oct-1. (PubMed id 8668543)9 Vigano M.A. and Staudt L.M. (1996)
    318. Hybrid cell extinction and re-expression of Oct-3 function correlates with differentiation potential. (PubMed id 8223459)9 Shimazaki T....Hamada H. (1993)
    319. Expression of Scl in mesoderm rescues hematopoiesis i n the absence of Oct-4. (PubMed id 19321862)9 Kong K.Y....Dahl R. (2009)
    320. Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data. (PubMed id 18522731)9 Sharov A.A....Ko M.S. (2008)
    321. Platypus Pou5f1 reveals the first steps in the evolution of trophectoderm differentiation and pluripotency in mammals. (PubMed id 19021737)9 Niwa H....Grutzner F. (2008)
    322. Cloning and characterization of the rabbit POU5F1 gene. (PubMed id 17852331)9 Shi J.J....Sheng H.Z. (2008)
    323. Post-translational regulation of Oct4 transcriptional activity. (PubMed id 19221599)9 Saxe J.P....Huang J. (2009)
    324. HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. (PubMed id 16510872)9 Covello K.L....Keith B. (2006)
    325. Induction of dedifferentiation, genomewide transcriptional programming, and epigenetic reprogramming by extracts of carcinoma and embryonic stem cells. (PubMed id 16195347)9 Taranger C.K....Collas P. (2005)
    326. Transcriptional regulation of nanog by OCT4 and SOX2. (PubMed id 15860457)9 Rodda D.J....Robson P. (2005)
    327. Oct-4 expression in inner cell mass and trophectoderm of human blastocysts. (PubMed id 11044462)9 Hansis C....Krey L.C. (2000)
    328. Oct-4: control of totipotency and germline determination. (PubMed id 10694754)9 Pesce M. and Scholer H.R. (2000)
    329. Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites. (PubMed id 9343393)9 Ambrosetti D.C....Dailey L. (1997)
    330. Expression of an exogenous human Oct-4 promoter ident ifies tumor-initiating cells in osteosarcoma. (PubMed id 19584295)9 Levings P.P....Gibbs C.P. (2009)
    331. The EWS-Oct-4 fusion gene encodes a transforming gene. (PubMed id 17564582)9 Lee J....Kim J. (2007)
    332. Redox regulation of the embryonic stem cell transcription factor oct-4 by thioredoxin. (PubMed id 15153603)9 Guo Y....Hromas R. (2004)
    333. Comparative analysis of human, bovine, and murine Oct -4 upstream promoter sequences. (PubMed id 11309664)9 Nordhoff V....SchAPler H.R. (2001)
    334. Synergism with germ line transcription factor Oct-4: viral oncoproteins share the ability to mimic a stem cell-specific activity. (PubMed id 10082529)9 Brehm A....Scholer H.R. (1999)
    335. Molecular cloning, genetic mapping, and developmental expression of bovine POU5F1. (PubMed id 10208969)9 van Eijk M.J....Gandolfi F. (1999)
    336. Targeting of de novo DNA methylation throughout the O ct-4 gene regulatory region in differentiating embryonic stem cells. (PubMed id 20376339)9 Athanasiadou R....Bird A. (2010)
    337. Oct-4 regulates the expression of Stella and Foxj2 at the Nanog locus: implications for the developmental competence of mouse oocyte s. (PubMed id 19477878)9 Zuccotti M....Garagna S. (2009)
    338. Oxytocin receptor- and Oct-4-expressing cells in human amniotic fluid. (PubMed id 18569033)9 Stefanidis K....Antsaklis A. (2008)
    339. Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. (PubMed id 18662995)9 van den Berg D.L....Poot R.A. (2008)
    340. Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies. (PubMed id 16854382)9 Hoffmann M.J....Schulz W.A. (2006)
    341. Gonadotropins affect Oct-4 gene expression during mouse oocyte growth. (PubMed id 16496425)9 Monti M....Zuccotti M. (2006)
    342. Expression of endoderm stem cell markers: evidence for the presence of adult stem cells in human thyroid glands. (PubMed id 16839255)9 Thomas T....Derwahl M. (2006)
    343. [Effect of nicotine on Oct-4 transcription of embryonic stem cells] (PubMed id 15612475)9 Zhang H....Qia Z. (2004)
    344. A genome-scale RNAi screen for Oct4 modulators define s a role of the Paf1 complex for embryonic stem cell identity. (PubMed id 19345177)9 Ding L....Buchholz F. (2009)
    345. Neuron-like differentiation and selective ablation of undifferentiated embryonic stem cells containing suicide gene with Oct-4 promoter. (PubMed id 18393636)9 Hara A....Mori H. (2008)
    346. Oct-4: the almighty POUripotent regulator? (PubMed id 17228302)9 Buitrago W. and Roop D.R. (2007)
    347. Molecular cloning and function of Oct-3 isoforms in c ynomolgus monkey embryonic stem cells. (PubMed id 16978059)9 Fujimoto Y....Nakatsuji N. (2006)
    348. From adult stem cells to cancer stem cells: Oct-4 Gene, cell-cell communication, and hormones during tumor promotion. (PubMed id 17261754)9 Trosko J.E. (2006)
    349. Developmental incompetency of denuded mouse oocytes u ndergoing maturation in vitro is ooplasmic in nature and is associated with abe rrant Oct-4 expression. (PubMed id 15817588)9 Chang H.C....Krey L.C. (2005)
    350. Activation of ectopic Oct-4 and Rex-1 promoters in human amniotic fluid cells. (PubMed id 16273276)9 Karlmark K.R....Hengstschlager M. (2005)
    351. Oct-4 regulates alternative platelet-derived growth factor alpha receptor gene promoter in human embryonal carcinoma cells. (PubMed id 8662786)9 Kraft H.J....van Zoelen E.J. (1996)
    352. The octamer motif present in the Rex-1 promoter binds Oct-1 and Oct-3 expressed by EC cells and ES cells. (PubMed id 7945330)9 Rosfjord E. and Rizzino A. (1994)
    353. Epigenetic changes to human umbilical cord blood cell s cultured with three proteins indicate partial reprogramming to a pluripotent state. (PubMed id 20096686)9 Wong C.J....Rogers I.M. (2010)
    354. Isolation and characterization of mesenchymal stem ce lls from the sub-amniotic human umbilical cord lining membrane. (PubMed id 19635009)9 Kita K....Jeschke M.G. (2010)
    355. Characterization of somatic cell nuclear reprogrammin g by oocytes in which a linker histone is required for pluripotency gene reacti vation. (PubMed id 20212135)9 Jullien J....Gurdon J.B. (2010)
    356. Hypoxia inducible factors regulate pluripotency and p roliferation in human embryonic stem cells cultured at reduced oxygen tensions. (PubMed id 19755485)9 Forristal C.E....Houghton F.D. (2010)
    357. Parthenogenetic embryo-like structures in the human o varian surface epithelium cell culture in postmenopausal women with no naturall y present follicles and oocytes. (PubMed id 18605894)9 Virant-Klun I....Meden-Vrtovec H. (2009)
    358. Cloning and characterization of cat POU5F1 and NANOG for identification of embryonic stem-like cells. (PubMed id 19293558)9 Yu X.F....Kong I.K. (2009)
    359. Quantitative transcription factor analysis of undiffe rentiated single human embryonic stem cells. (PubMed id 19815608)9 StAYhlberg A....Semb H. (2009)
    360. Cross-regulation of the Nanog and Cdx2 promoters. (PubMed id 19564890)9 Chen L....Daley G.Q. (2009)
    361. MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. (PubMed id 18806776)9 Tay Y....Rigoutsos I. (2008)
    362. A computational model for understanding stem cell, trophectoderm and endoderm lineage determination. (PubMed id 18941526)9 Chickarmane V. and Peterson C. (2008)
    363. Isolation of human bone marrow mesenchymal stem cells using different membrane markers: comparison of colony/cloning efficiency, differentiation potential, and molecular profile. (PubMed id 18800875)9 Kastrinaki M.C....Papadaki H.A. (2008)
    364. A core Klf circuitry regulates self-renewal of embryonic stem cells. (PubMed id 18264089)9 Jiang J....Ng H.H. (2008)
    365. IFATS collection: Selenium induces improvement of stem cell behaviors in human adipose-tissue stromal cells via SAPK/JNK and stemness acting signals. (PubMed id 18583539)9 Kim J.H....Kang S.K. (2008)
    366. Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells. (PubMed id 17352742)9 Hattori N....Shiota K. (2007)
    367. Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation. (PubMed id 17288545)9 Battula V.L....Buhring H.J. (2007)
    368. Isolation and characterization of EG-like cells from Chinese swamp buffalo (Bubalus bubalis). (PubMed id 17532234)9 Huang B....Li M.M. (2007)
    369. Bovine embryonic stem cells. (PubMed id 17141027)9 Roach M....Tian X.C. (2006)
    370. Comparisons between transcriptional regulation and RNA expression in human embryonic stem cell lines. (PubMed id 16846370)9 Player A....Kawasaki E.S. (2006)
    371. Undifferentiated mouse mesenchymal stem cells spontaneously express neural and stem cell markers Oct-4 and Rex-1. (PubMed id 16793732)9 Lamoury F.M....Brew B.J. (2006)
    372. Developmental expression of pluripotency determining factors in caprine embryos: novel pattern of NANOG protein localization in the nucleolus. (PubMed id 16894532)9 He S....Keefer C. (2006)
    373. Derivation of human embryonic stem cells from developing and arrested embryos. (PubMed id 16990582)9 Zhang X....Stojkovic M. (2006)
    374. Monitoring differentiation of human embryonic stem cells using real-time PCR. (PubMed id 16081663)9 Noaksson K....Sartipy P. (2005)
    375. Comparative genomics on mammalian Fgf3-Fgf4 locus. (PubMed id 15942670)9 Katoh M. and Katoh M. (2005)
    376. Comparative genomics on SOX2 orthologs. (PubMed id 16077994)9 Katoh Y. and Katoh M. (2005)
    377. Transcription factor Sox-2 inhibits co-activator stimulated transcription. (PubMed id 15349837)9 Bernadt C.T....Rizzino A. (2004)
    378. Oct-4-expressing cells in human amniotic fluid: a new source for stem cell research? (PubMed id 12832377)9 Prusa A.R....Hengstschlager M. (2003)
    379. Establishment of SSEA-1- and Oct-4-expressing rat embryonic stem-like cell lines and effects of cytokines of the IL-6 family on clonal growth. (PubMed id 10896787)9 Vassilieva S....Wobus A.M. (2000)
    380. Effects of differentiation on the transcriptional regulation of the FGF-4 gene: critical roles played by a distal enhancer. (PubMed id 9740330)9 Lamb K.A. and Rizzino A. (1998)
    381. Phosphorylation and DNA binding of the octamer bindin g transcription factor Oct-3. (PubMed id 7626120)9 Rosfjord E....Rizzino A. (1995)
    382. Identification of differentially expressed mRNAs duri ng neuronal differentiation of P19 embryonal carcinoma cells. (PubMed id 7501302)9 Suzuki Y....Takagi T. (1995)
    383. Changes in Hox1.6, c-jun, and Oct-3 gene expressions are associated with teratocarcinoma F9 cell differentiation in three different ways of induction. (PubMed id 8453995)9 Iwai S.A....Nishimune Y. (1993)
    384. The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer. (PubMed id 1915274)9 Okazawa H....Hamada H. (1991)
    385. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. (PubMed id 18594515)9 Kim J.B....Scholer H.R. (2008)
    386. Identification of the transactivation domain of the transcription factor Sox-2 and an associated co-activator. (PubMed id 10660531)9 Nowling T.K....Rizzino A. (2000)
    387. Efficient derivation of Chinese human embryonic stem cell lines from frozen embryos. (PubMed id 20186511)9 Li C....Jin Y. (2010)
    388. FM19G11, a new hypoxia-inducible factor (HIF) modulat or, affects stem cell differentiation status. (PubMed id 19897487)9 Moreno-Manzano V....SA!nchez-Puelles J.M. (2010)
    389. Differential expression profiling between atypical te ratoid/rhabdoid and medulloblastoma tumor in vitro and in vivo using microarray analysis. (PubMed id 19902219)9 Ma H.I....Wong T.T. (2010)
    390. Human adipose-derived mesenchymal stem cells in vitro : evaluation of an optimal expansion medium preserving stemness. (PubMed id 19929458)9 Baer P.C....Geiger H. (2010)
    391. Generation of induced pluripotent stem cells from new born marmoset skin fibroblasts. (PubMed id 20363201)9 Wu Y....Hornsby P.J. (2010)
    392. CD24+ cells from hierarchically organized ovarian can cer are enriched in cancer stem cells. (PubMed id 20190812)9 Gao M.Q....Cho N.H. (2010)
    393. Generation of human induced pluripotent stem cells fr om a Bombay individual: moving towards 'universal-donor' red blood ce lls. (PubMed id 19912985)9 Seifinejad A....Baharvand H. (2010)
    394. Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic developme nt. (PubMed id 19915186)9 Yamada M....Umezawa A. (2010)
    395. Analysis of SOX2 expression in developing human testi s and germ cell neoplasia. (PubMed id 19876845)9 Sonne S.B....Rajpert-De-Meyts E. (2010)
    396. The effect of human embryonic stem cells (hESCs) long -term normoxic and hypoxic cultures on the maintenance of pluripotency. (PubMed id 20177991)9 Zachar V....Fink T. (2010)
    397. Cryopreservation of primate embryonic stem cells with chemically-defined solution without Me2SO. (PubMed id 19857481)9 Nishigaki T....Iwata H. (2010)
    398. In vitro differentiation of GABAergic cells from bone marrow stromal cells using potassium chloride as inducer. (PubMed id 20479529)9 Gharibani P.M....Arabkheradmand J. (2010)
    399. DHP-derivative and low oxygen tension effectively ind uces human adipose stromal cell reprogramming. (PubMed id 20161735)9 Jee M.K....Kang S.K. (2010)
    400. Embryonic-like stem cell derived from adult bone marr ow: immature morphology, cell surface markers, ultramicrostructure and differen tiation into multinucleated fibers in vitro. (PubMed id 20385079)9 Pang R....Zhang C. (2010)
    401. Isolation of multipotent stem cells in human periodon tal ligament using stage-specific embryonic antigen-4. (PubMed id 19945209)9 Kawanabe N....Yamashiro T. (2010)
    402. Characterisation of the liver progenitor cell niche i n liver diseases: potential involvement of Wnt and Notch signalling. (PubMed id 19880964)9 Spee B....Roskams T. (2010)
    403. Lentivirus-modified human umbilical cord mesenchymal stem cells maintain their pluripotency. (PubMed id 19961436)9 Qian H....Sun J. (2010)
    404. Isolation and characterization of stem cells derived from human third molar tooth germs of young adults: implications in neo-vascula rization, osteo-, adipo- and neurogenesis. (PubMed id 19721467)9 Yalvac M.E....Kose G.T. (2010)
    405. Astaxanthin improves the proliferative capacity as we ll as the osteogenic and adipogenic differentiation potential in neural stem ce lls. (PubMed id 20385192)9 Kim J.H....Choi Y.H. (2010)
    406. Generation of induced pluripotent stem cells by repro gramming human fibroblasts with the stemgent human TF lentivirus set. (PubMed id 19997062)9 Wu D....Yao S. (2009)
    407. Generation of induced pluripotent stem cells from neu ral stem cells. (PubMed id 19798081)9 Kim J.B....SchAPler H.R. (2009)
    408. Self-renewal and pluripotency is maintained in human embryonic stem cells by co-culture with human fetal liver stromal cells express ing hypoxia inducible factor 1alpha. (PubMed id 19492421)9 Ji L....Pei X.T. (2009)
    409. Regulatory circuits underlying pluripotency and repro gramming. (PubMed id 19427042)9 Do J.T. and SchAPler H.R. (2009)
    410. [Effects of different culture conditions on isolation and expansion of stem cells from second-trimester amniotic fluids] (PubMed id 19570457)9 Liu H....Pei X.T. (2009)
    411. In vitro propagation and characterization of neoplast ic stem/progenitor-like cells from human prostate cancer tissue. (PubMed id 19644960)9 GuzmA!n-RamA-rez N....Cecchini M.G. (2009)
    412. Endothelial cell differentiation of human breast tumour stem/progenitor cells. (PubMed id 18410528)9 Bussolati B....Camussi G. (2009)
    413. Live cell imaging distinguishes bona fide human iPS c ells from partially reprogrammed cells. (PubMed id 19826408)9 Chan E.M....Schlaeger T.M. (2009)
    414. Statins inhibit the growth of variant human embryonic stem cells and cancer cells in vitro but not normal human embryonic stem cells . (PubMed id 19438511)9 Gauthaman K....Bongso A. (2009)
    415. Cell lines derived from human parthenogenetic embryos can display aberrant centriole distribution and altered expression levels of m itotic spindle check-point transcripts. (PubMed id 20058199)9 Brevini T.A....Gandolfi F. (2009)
    416. Neural ganglioside GD2 identifies a subpopulation of mesenchymal stem cells in umbilical cord. (PubMed id 19471109)9 Xu J....Han Z. (2009)
    417. [Analysis on the expression of the stem cells related genes in hepatocellular carcinoma cell lines] (PubMed id 19719918)9 Zou C....Zhang Y.S. (2009)
    418. A tumorigenic homeobox (HOX) gene expressing human ga stric cell line derived from putative gastric stem cell. (PubMed id 19424076)9 Yang Y.C....Wu D.C. (2009)
    419. Differentiation potential of human pancreatic stem cells for epithelial- and endothelial-like cell types. (PubMed id 18692369)9 Meier K....Daum N. (2009)
    420. Acetylation of sox2 induces its nuclear export in emb ryonic stem cells. (PubMed id 19591226)9 Baltus G.A....Kadam S. (2009)
    421. Use of human amnion epithelial cells as a feeder laye r to support undifferentiated growth of mouse embryonic stem cells. (PubMed id 19508128)9 Lai D....Liu T. (2009)
    422. Characterization and hepatic differentiation of skin- derived precursors from adult foreskin by sequential exposure to hepatogenic cy tokines and growth factors reflecting liver development. (PubMed id 19720137)9 De Kock J....Snykers S. (2009)
    423. Quantitative comparison of stem cell marker-positive cells in fetal and term human amnion. (PubMed id 19501410)9 Izumi M....Miki T. (2009)
    424. Embryonic stem cell markers expression in cancers. (PubMed id 19268426)9 Schoenhals M....Klein B. (2009)
    425. Identification and characterization of cancer stem-li ke cells from primary carcinoma of the cervix uteri. (PubMed id 19787230)9 Feng D....Tian Z. (2009)
    426. Multipotent mesenchymal stem cells from amniotic flui d originate neural precursors with functional voltage-gated sodium channels. (PubMed id 19548144)9 Mareschi K....Fagioli F. (2009)
    427. [Identification and characterization of ovarian cance r stem-like cells from primary tumor.] (PubMed id 20193423)9 Lai D.M....Cheng W.W. (2009)
    428. Derivation and characterization of two sibling human embryonic stem cell lines from discarded grade III embryos. (PubMed id 18616385)9 Inamdar M.S....VijayRaghavan K. (2009)
    429. Ex vivo expansion of adipose tissue-derived stem cell s in spinner flasks. (PubMed id 19404993)9 Zhu Y....Cui Z. (2009)
    430. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. (PubMed id 18555785)9 Chen X....Ng H.H. (2008)
    431. Multipotent mesenchymal stem cells from adult human eye conjunctiva stromal cells. (PubMed id 17825086)9 Nadri S....Izadpanah R. (2008)
    432. [Two vital transcriptional factors Oct-4 and Nanog to keep the pluripotency and self-renewal of stem cells and related regulation ne twork] (PubMed id 18487140)9 Zhou Y.Y. and Zeng F.Y. (2008)
    433. CXCR4+/FLK-1+ biomarkers select a cardiopoietic lineage from embryonic stem cells. (PubMed id 18369102)9 Nelson T.J....Terzic A. (2008)
    434. Epidermal neural crest stem cells (EPI-NCSC) and pluripotency. (PubMed id 18712509)9 Sieber-Blum M. and Hu Y. (2008)
    435. Successful vitrification of human amnion-derived mesenchymal stem cells. (PubMed id 18541648)9 Moon J.H....Kim H.K. (2008)
    436. The stemness gene expression of cultured human amniotic epithelial cells in serial passages. (PubMed id 19024980)9 Simat S.F....Tan G.C. (2008)
    437. Postnatal stem/progenitor cells derived from the dental pulp of adult chimpanzee. (PubMed id 18430234)9 Cheng P.H....Chan A.W. (2008)
    438. Characterization and genetic manipulation of human umbilical cord vein mesenchymal stem cells: potential application in cell-based gene therapy. (PubMed id 18399786)9 Kermani A.J....Mowla S.J. (2008)
    439. The lymphovascular embolus of inflammatory breast cancer expresses a stem cell-like phenotype. (PubMed id 18599608)9 Xiao Y....Barsky S.H. (2008)
    440. [Effect of adenoviral vectors on the differentiation potential of human bone marrow mesenchymal stem cells] (PubMed id 18676244)9 Shan Z.X....Yu X.Y. (2008)
    441. Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells. (PubMed id 19030024)9 Liu X....Kang J. (2008)
    442. Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling. (PubMed id 18332870)9 Tsuchida R....Malkin D. (2008)
    443. Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. (PubMed id 18347094)9 Cole M.F....Young R.A. (2008)
    444. Stemness gene expression profile of human adipose derived stem cells in long-term culture. (PubMed id 19024984)9 Zaman W.S....Chua K.H. (2008)
    445. Upregulation of SOX-2, FZD9, Nestin, OCT-4 and FGF-4 expression in human chorion derived-stem cells after angiogenic induction. (PubMed id 19024982)9 Abdul Rahman H....Chua K.H. (2008)
    446. Characterization and expansion of mesenchymal progenitor cells from first-trimester chorionic villi of human placenta. (PubMed id 18985476)9 Poloni A....Leoni P. (2008)
    447. Putative stem cells with an embryonic character isolated from the ovarian surface epithelium of women with no naturally present follicles and oocytes. (PubMed id 18452550)9 Virant-Klun I....Meden-Vrtovec H. (2008)
    448. Adipose-derived stem cell: a better stem cell than BMSC. (PubMed id 18636461)9 Zhu Y....Cui Z. (2008)
    449. Long-term culture of Japanese human embryonic stem cells in feeder-free conditions. (PubMed id 18468232)9 Navarro-Alvarez N....Kobayashi N. (2008)
    450. Rest-mediated regulation of extracellular matrix is crucial for neural development. (PubMed id 18987749)9 Sun Y.M....Buckley N.J. (2008)
    451. Caspase activity mediates the differentiation of embryonic stem cells. (PubMed id 18522852)9 Fujita J....Zwaka T.P. (2008)
    452. Identification of a tumor-initiating stem cell population in human renal carcinomas. (PubMed id 18614581)9 Bussolati B....Camussi G. (2008)
    453. Robust generation of hemangioblastic progenitors from human embryonic stem cells. (PubMed id 18729794)9 Lu S.J....Lanza R. (2008)
    454. Identification and characterization of ovarian cancer-initiating cells from primary human tumors. (PubMed id 18519691)9 Zhang S....Nephew K.P. (2008)
    455. From fibroblasts to iPS cells: induced pluripotency b y defined factors. (PubMed id 18668528)9 Zhao R. and Daley G.Q. (2008)
    456. Multilineage potential of side population cells from human amnion mesenchymal layer. (PubMed id 18522232)9 Kobayashi M....Sakuragawa N. (2008)
    457. An extended transcriptional network for pluripotency of embryonic stem cells. (PubMed id 18358816)9 Kim J....Orkin S.H. (2008)
    458. Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. (PubMed id 18371436)9 Brambrink T....Jaenisch R. (2008)
    459. OCT4: biological functions and clinical applications as a marker of germ cell neoplasia. (PubMed id 17117392)9 Cheng L....Looijenga L.H. (2007)
    460. Comparative growth behaviour and characterization of stem cells from human Wharton's jelly. (PubMed id 18062871)9 Fong C.Y....Bongso A. (2007)
    461. Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells. (PubMed id 17521616)9 Grayson W.L....Ma T. (2007)
    462. Regulated Nodal signaling promotes differentiation of the definitive endoderm and mesoderm from ES cells. (PubMed id 17535850)9 Takenaga M....Hori Y. (2007)
    463. The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors. (PubMed id 17521702)9 Li Y....Lau Y.F. (2007)
    464. Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation. (PubMed id 18274628)9 Mullen E.M....Cooney A.J. (2007)
    465. Expression of cell-surface antigens and embryonic ste m cell pluripotency genes in equine blastocysts. (PubMed id 17999600)9 Guest D.J. and Allen W.R. (2007)
    466. Comparative integromics on JMJD1C gene encoding histone demethylase: conserved POU5F1 binding site elucidating mechanism of JMJD1C expression in undifferentiated ES cells and diffuse-type gastric cancer. (PubMed id 17549425)9 Katoh M. and Katoh M. (2007)
    467. A unique human blood-derived cell population displays high potential for producing insulin. (PubMed id 17588534)9 Zhao Y....Chen M. (2007)
    468. Generation and characterization of rabbit embryonic stem cells. (PubMed id 17038672)9 Wang S....Ji W. (2007)
    469. Gene expression analysis of hematopoietic progenitor cells identifies Dlg7 as a potential stem cell gene. (PubMed id 17322106)9 Gudmundsson K.O....Rafnar T. (2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5460 HGNC: 9221 AceView: POU5F1 Ensembl:ENSG00000204531 euGenes: HUgn5460
    ECgene: POU5F1 H-InvDB: POU5F1

    (According to HUGE)
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    NameDescription
    PharmGKB entry for POU5F1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Oct-4

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     Cell Lines associated with POU5F1: Human Embryonic Stem Cell Line ESI-017,
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