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POU5F1 Gene

protein-coding   GIFtS: 69
GCID: GC06M031136

POU Class 5 Homeobox 1

(Previous names: POU domain class 5, transcription factor 1)
(Previous symbol: OTF3)
  See POU5F1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
POU Class 5 Homeobox 11 2     Oct-32 3
OTF31 2 3 5     Oct-42 3
OCT32 3 5     POU Domain Class 5, Transcription Factor 11
Octamer-Binding Protein 32 3     OTF42
Octamer-Binding Protein 42 3     POU Domain Transcription Factor OCT42
Octamer-Binding Transcription Factor 32 3     POU Domain, Class 5, Transcription Factor 12
OCT42 3     POU-Type Homeodomain-Containing DNA-Binding Protein2
OTF-32 3     

External Ids:    HGNC: 92211   Entrez Gene: 54602   Ensembl: ENSG000002045317   OMIM: 1641775   UniProtKB: Q018603   

Export aliases for POU5F1 gene to outside databases

Previous GC identifers: GC08P127435 GC06M031188 GC06M030902 GC06M031238 GC06M031240 GC06M031133 GC06M030934


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POU5F1 Gene:
This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic
development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with
tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which
also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation
initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations.
Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. (provided by RefSeq, Oct 2013)

GeneCards Summary for POU5F1 Gene:
POU5F1 (POU class 5 homeobox 1) is a protein-coding gene. Diseases associated with POU5F1 include central nervous system germinoma, and germinoma. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is POU5F2.

UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with
SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1,
FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency

Gene Wiki entry for POU5F1 (Oct-4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  
NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the POU5F1 gene promoter:
         AP-1   MyoD   STAT3   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): POU5F1 promoter sequence
   Search Chromatin IP Primers for POU5F1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POU5F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.33

POU5F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POU5F1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031136:  view genomic region     (about GC identifiers)

Start:
31,132,114 bp from pter      End:
31,148,508 bp from pter
Size:
16,395 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167245 2,429,238-2,435,593      Chr6-,NT_167246 2,480,458-2,486,814      Chr6-,NT_167248 2,427,966-2,434,320     
Chr6-,NT_113891.2 2,646,867-2,653,222      Chr6-,NT_167247 2,514,037-2,520,393      Chr6-,NT_167249 2,467,051-2,473,404     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860 (See protein sequence)
Recommended Name: POU domain, class 5, transcription factor 1  
Size: 360 amino acids; 38571 Da
Subunit: Interacts with UBE2I and ZSCAN10 (By similarity). Interacts with PKM. Interacts with WWP2
Developmental stage: Highly expressed in undifferentiated embryonic stem cells and expression decreases gradually
after embryoid body (EB) formation
Biotechnology: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors
are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent
stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes
Miscellaneous: Several pseudogenes of POU5F1 have been described on chromosomes 1, 3, 8, 10 and 12. 2 of them,
localized in chromosomes 8 and 10, are transcribed in cancer tissues but not in normal ones and may be involved
in the regulation of POU5F1 gene activity in carcinogenesis
Secondary accessions: A6NCS1 A6NLL8 D2IYK4 P31359 Q15167 Q15168 Q16422 Q5STF3 Q5STF4
Alternative splicing: 2 isoforms:  Q01860-1   Q01860-2   

Explore the universe of human proteins at neXtProt for POU5F1: NX_Q01860

Explore proteomics data for POU5F1 at MOPED

Post-translational modifications: 

  • Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for
    enhanced YES1 expression (By similarity)1
  • Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation (By
    similarity)1
  • ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation
    at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POU5F1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001167002.1  NP_001272915.1  NP_001272916.1  NP_002692.2  NP_976034.4  

    ENSEMBL proteins: 
     ENSP00000389359   ENSP00000259915   ENSP00000425479   ENSP00000475880   ENSP00000475512  
     ENSP00000425083  
    Reactome Protein details: Q01860

    POU5F1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for POU5F1
    OriGene Protein Over-expression Lysate for POU5F1
    OriGene MassSpec for POU5F1
    OriGene Custom Protein Services for POU5F1
    GenScript Custom Purified and Recombinant Proteins Services for POU5F1
    Novus Biologicals POU5F1 Proteins
    Novus Biologicals POU5F1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for POU5F1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for POU5F1 

    POU5F1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of POU5F1
    R&D Systems Antibodies for POU5F1 (Oct-4A, Oct-3/4)
    Cell Signaling Technology (CST) Antibodies for POU5F1  (4-Oct)
    OriGene Antibodies for POU5F1
    OriGene Custom Antibody Services for POU5F1
    Novus Biologicals POU5F1 Antibodies
    Abcam antibodies for POU5F1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for POU5F1
    LSBio Antibodies in human, mouse, rat for POU5F1

    POU5F1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for POU5F1
    R&D Systems Proteome Profiler Antibody Arrays for POU5F1 (Oct-3/4)
    GenScript Custom Assay Services for POU5F1
    Cell Signaling Technology (CST) Sandwich ELISA Kits for POU5F1 (4-Oct)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for POU5F1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POU: Homeoboxes / POU class

    Selected InterPro protein domains (see all 7):
     IPR010982 Lambda_DNA-bd_dom
     IPR013847 POU
     IPR000327 POU_specific
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry Q01860

    ProtoNet protein and cluster: Q01860

    2 Blocks protein domains:
    IPB000327 POU domain
    IPB013847 POU


    UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860
    Domain: The POU-specific domain mediates interaction with PKM
    Similarity: Belongs to the POU transcription factor family. Class-5 subfamily
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 POU-specific domain


    Find genes that share domains with POU5F1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PO5F1_HUMAN, Q01860
    Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with
    SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1,
    FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency
    Induction: Transcriptional activity is positively regulated by PKM

         Genatlas biochemistry entry for POU5F1:
    POU domain,class 5,transcription factor 1,expressed in neuronal cells,with OCT5 likely a proteolytic product of
    OCT3

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity ISS--
    GO:0003677DNA binding IDA16153702
    GO:0003700sequence-specific DNA binding transcription factor activity IDA16153702
    GO:0005515protein binding IPI11099378
    GO:0008134transcription factor binding IPI19736317
         
    Find genes that share ontologies with POU5F1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for POU5F1:
     Increased gamma-H2AX phosphory 

         12 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Pou5f1):
     behavior/neurological  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     hematopoietic system  integument  liver/biliary system  mortality/aging  nervous system 
     normal  reproductive system 

    Find genes that share phenotypes with POU5F1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pou5f1tm1.1Scho for POU5F1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for POU5F1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for POU5F1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for POU5F1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for POU5F1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  ATTTGCATAA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target POU5F1:
    hsa-mir-128-3p (MIRT022019), hsa-mir-145-5p (MIRT004904)

    Block miRNA regulation of human, mouse, rat POU5F1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate POU5F1:
    hsa-miR-3606 hsa-miR-3658 hsa-miR-103a-2* hsa-miR-3657 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidPOU5F1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for POU5F1
    Predesigned siRNA for gene silencing in human, mouse, rat POU5F1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for POU5F1

    Clone
    Products:
         
    OriGene clones in human, mouse for POU5F1 (see all 16)
    OriGene ORF clones in mouse, rat for POU5F1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): POU5F1 (NM_002701)
    Sino Biological Human cDNA Clone for POU5F1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU5F1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU5F1
    Addgene plasmids for POU5F1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for POU5F1
    ESI BIO Cell Lines for POU5F1: 
    Human Embryonic Stem Cell Line ESI-017, Human Embryonic Stem Cell Line ESI-035,
    Human Embryonic Stem Cell Line ESI-049, Human Embryonic Stem Cell Line ESI-051,
    Human Embryonic Stem Cell Line ESI-053
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU5F1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11760) for POU5F1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PO5F1_HUMAN, Q01860: Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18000303
    GO:0005654nucleoplasm IDA--
    GO:0005667transcription factor complex IDA19736317
    GO:0005737cytoplasm IDA18281244
    GO:0005829cytosol IDA18000303

    Find genes that share ontologies with POU5F1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POU5F1 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    2Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway and Pluripotency0.55
    3Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency0.50
    4Ca-dependent events
    Development Role of Activin A in cell differentiation and proliferation0.32
    5Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch


    Find genes that share SuperPaths with POU5F1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for POU5F1
        Transcriptional Regulatory Network in Embryonic Stem Cell
    Oct4 in Mammalian ESC Pluripotency
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency
    Human Early Embryo Development

    1 Cell Signaling Technology (CST) Pathway for POU5F1
        Wnt / Hedgehog / Notch

    1 GeneGo (Thomson Reuters) Pathway for POU5F1
        Development Role of Activin A in cell differentiation and proliferation

    4 BioSystems Pathways for POU5F1
        Wnt Signaling Pathway and Pluripotency
    SIDS Susceptibility Pathways
    Cardiac Progenitor Differentiation
    HIF-2-alpha transcription factor network


    3 Reactome Pathways for POU5F1
        POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
    Transcriptional regulation of pluripotent stem cells
    POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation


        Pathway & Disease-focused RT2 Profiler PCR Arrays including POU5F1 (see all 6): 
              Cell Lineage Identification in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for POU5F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for POU5F1 (Q018601, 2, 3 ENSP000002599154) via UniProtKB, MINT, STRING, and/or I2D (see all 229) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    HIST1H4FP628053I2D: score=2 
    HIST1H4HP628053I2D: score=2 
    HIST1H4IP628053I2D: score=2 
    HIST1H4JP628053I2D: score=2 
    HIST1H4KP628053I2D: score=2 
    HIST1H4LP628053I2D: score=2 
    HIST2H4AP628053I2D: score=2 
    HIST2H4BP628053I2D: score=2 
    HIST4H4P628053I2D: score=2 
    WWP2O003081, 3EBI-475687,EBI-743923 I2D: score=1 
    EHMT2Q96KQ73I2D: score=1 
    ENSG00000206376Q96KQ73I2D: score=1 
    ENSG00000227333Q96KQ73I2D: score=1 
    ENSG00000232045Q96KQ73I2D: score=1 
    ENSG00000236759Q96KQ73I2D: score=1 
    ENSG00000238134Q96KQ73I2D: score=1 
    HIST2H3AQ71DI33I2D: score=2 
    HIST2H3CQ71DI33I2D: score=2 
    HIST2H3DQ71DI33I2D: score=2 
    FOXD3Q9UJU51, 3, ENSP000003601574EBI-475687,EBI-475674 I2D: score=2 STRING: ENSP00000360157
    NANOGQ9H9S03, ENSP000002293074I2D: score=4 STRING: ENSP00000229307
    ARID3BQ8IVW63, ENSP000003431264I2D: score=3 STRING: ENSP00000343126
    MNAT1P519483, ENSP000002612454I2D: score=3 STRING: ENSP00000261245
    SP1P080473, ENSP000003293574I2D: score=3 STRING: ENSP00000329357
    ETS2P150363, ENSP000003533444I2D: score=2 STRING: ENSP00000353344
    GATAD2AQ86YP43, ENSP000003515524I2D: score=2 STRING: ENSP00000351552
    HDAC1Q135473, ENSP000003626494I2D: score=2 STRING: ENSP00000362649
    HELLSQ9NRZ93, ENSP000002390274I2D: score=2 STRING: ENSP00000239027
    HMGB1P094293, ENSP000003430404I2D: score=2 STRING: ENSP00000343040
    MBD3O959833, ENSP000001568254I2D: score=2 STRING: ENSP00000156825
    MTA3Q9BTC83, ENSP000003850454I2D: score=2 STRING: ENSP00000385045
    SMARCA4P515323, ENSP000003507204I2D: score=2 STRING: ENSP00000350720
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    MTA1Q133303, ENSP000003336334I2D: score=1 STRING: ENSP00000333633
    PKMP146183, ENSP000003201714I2D: score=1 STRING: ENSP00000320171
    RBBP7Q165763, ENSP000003694274I2D: score=1 STRING: ENSP00000369427
    THAP11Q96EK43, ENSP000003046894I2D: score=1 STRING: ENSP00000304689
    UBE2IP632793, ENSP000003248974I2D: score=1 STRING: ENSP00000324897
    EWSR1Q018443, ENSP000003810314I2D: score=4 STRING: ENSP00000381031
    SOX2P484313, ENSP000003235884I2D: score=4 STRING: ENSP00000323588
    HMGB2P265833, ENSP000002965034I2D: score=3 STRING: ENSP00000296503
    SOX10P566933, ENSP000003541304I2D: score=2 STRING: ENSP00000354130
    SOX8P570733, ENSP000002938944I2D: score=1 STRING: ENSP00000293894
    GATAD2BQ8WXI93, ENSP000003576444I2D: score=3 STRING: ENSP00000357644
    MTA2O947763, ENSP000002788234I2D: score=2 STRING: ENSP00000278823
    HDAC2Q927693, ENSP000003813314I2D: score=2 STRING: ENSP00000381331
    KDM1AO603413, ENSP000003490494I2D: score=2 STRING: ENSP00000349049
    NACC1Q96RE73, ENSP000002924314I2D: score=2 STRING: ENSP00000292431
    HCFC1P516103, ENSP000003095554I2D: score=2 STRING: ENSP00000309555
    RCOR2Q8IZ403, ENSP000003014594I2D: score=2 STRING: ENSP00000301459
    SALL1Q9NSC23, ENSP000002510204I2D: score=1 STRING: ENSP00000251020
    SOX15O602483, ENSP000003553544I2D: score=1 STRING: ENSP00000355354
    SAE1Q9UBE03, ENSP000002702254I2D: score=1 STRING: ENSP00000270225
    UBA2Q9UBT23, ENSP000002465484I2D: score=1 STRING: ENSP00000246548
    CHD4Q148393, ENSP000003495084I2D: score=2 STRING: ENSP00000349508
    DPF2Q927853, ENSP000002522684I2D: score=2 STRING: ENSP00000252268
    SMARCC1Q929223, ENSP000002544804I2D: score=2 STRING: ENSP00000254480
    OGTO152943, ENSP000003628244I2D: score=2 STRING: ENSP00000362824
    ZFP42Q96MM33, ENSP000003176864I2D: score=2 STRING: ENSP00000317686
    MSH6P527013, ENSP000002344204I2D: score=2 STRING: ENSP00000234420
    CREB1P162203, ENSP000003876994I2D: score=2 STRING: ENSP00000387699
    DNMT3AQ9Y6K13, ENSP000002647094I2D: score=2 STRING: ENSP00000264709
    DNMT3LQ9UJW33, ENSP000002701724I2D: score=2 STRING: ENSP00000270172
    KLF4O434743, ENSP000003638044I2D: score=2 STRING: ENSP00000363804
    SALL4Q9UJQ43I2D: score=4 
    NR0B1P518433I2D: score=3 
    ACIN1Q9UKV33I2D: score=2 
    ACTL6AO960193I2D: score=2 
    AMOTL2Q9Y2J43I2D: score=2 
    ASF1AQ9Y2943I2D: score=2 
    ATF2P153363I2D: score=2 
    BRWD1Q9NSI63I2D: score=2 
    CDK1P064933I2D: score=2 
    CHD1O146463I2D: score=2 
    CTBP1Q133633I2D: score=2 
    CTBP2P565453I2D: score=2 
    CUBNO604943I2D: score=2 
    CUL4BQ136203I2D: score=2 
    DDB1Q165313I2D: score=2 
    DHX9Q082113I2D: score=2 
    DNAJA1P316893I2D: score=2 
    EMDP504023I2D: score=2 
    HIRAP541983I2D: score=2 
    HIST3H2BBQ8N2573I2D: score=2 
    HNRNPABQ997293I2D: score=2 
    HNRNPLP148663I2D: score=2 
    HNRNPUQ008393I2D: score=2 
    ILF2Q129053I2D: score=2 
    INO80Q9ULG13I2D: score=2 
    JADE1Q6IE813I2D: score=2 
    KAT7O952513I2D: score=2 
    KPNA2P522923I2D: score=2 
    KPNA3O005053I2D: score=2 
    MATR3P432433I2D: score=2 
    MITFO750303I2D: score=2 
    NCLP193383I2D: score=2 
    NFRKBQ6P4R83I2D: score=2 
    NFYCQ139523I2D: score=2 
    NUDCQ9Y2663I2D: score=2 
    P4HA1P136743I2D: score=2 
    PPP2R1AP301533I2D: score=2 
    PSMB6P280723I2D: score=2 
    RFX2P483783I2D: score=2 
    RNF2Q994963I2D: score=2 
    RPA1P276943I2D: score=2 
    RPA3P352443I2D: score=2 
    RYBPQ8N4883I2D: score=2 
    SALL3Q9BXA93I2D: score=2 
    SMARCA5O602643I2D: score=2 
    SSRP1Q089453I2D: score=2 
    SUMO1P631653I2D: score=2 
    SUPT16HQ9Y5B93I2D: score=2 
    TFE3P195323I2D: score=2 
    TFEBP194843I2D: score=2 
    TOP2AP113883I2D: score=2 
    TRIM24O151643I2D: score=2 
    TRIM33Q9UPN93I2D: score=2 
    TTF2Q9UNY43I2D: score=2 
    UBN2Q6ZU653I2D: score=2 
    WDR5P619643I2D: score=2 
    XRCC1P188873I2D: score=2 
    XRCC5P130103I2D: score=2 
    ZBTB43O432983I2D: score=2 
    ZNF143P527473I2D: score=2 
    ZNF513Q8N8E23I2D: score=2 
    ACTA1P681333I2D: score=1 
    ACTG1P632613I2D: score=1 
    AGR2O959943I2D: score=1 
    AKAP8O438233I2D: score=1 
    C11orf30Q7Z5893I2D: score=1 
    C17orf49Q8IXM23I2D: score=1 
    CABIN1Q9Y6J03I2D: score=1 
    CAPNS1P046323I2D: score=1 
    EEF1A1P681043I2D: score=1 
    EEF2P136393I2D: score=1 
    EIF5BO608413I2D: score=1 
    EZH2Q159103I2D: score=1 
    FKBP7Q9Y6803I2D: score=1 
    FOXP4Q8IVH23I2D: score=1 
    FRG1Q143313I2D: score=1 
    GAPDHP044063I2D: score=1 
    HIST1H1TP224923I2D: score=1 
    HNRNPKP619783I2D: score=1 
    KAT2AQ928303I2D: score=1 
    KAT5Q929933I2D: score=1 
    KIAA1551Q9HCM13I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001714endodermal cell fate specification IDA--
    GO:0001824blastocyst development ISS--
    GO:0003130BMP signaling pathway involved in heart induction IMP19736317
    GO:0006355regulation of transcription, DNA-templated IDA16153702
    GO:0006366transcription from RNA polymerase II promoter ISS--

    Find genes that share ontologies with POU5F1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POU5F1 (PO5F1)

    2 DrugBank Compounds for POU5F1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DopamineDopamin (see all 6)51-61-6transportersubstrate20402963
    NorepinephrineArterenol (see all 4)51-41-2transportersubstrate20402963

    4 Novoseek inferred chemical compound relationships for POU5F1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    slex 56.7 5 16894532 (2), 19755485 (1), 15342930 (1), 20177991 (1)
    retinoic acid 36.8 13 1915274 (3), 7501302 (2), 12841847 (1), 19719918 (1) (see all 8)
    vegf 8.99 1 18729794 (1), 18332870 (1)
    oxygen 0 5 19755485 (1), 20177991 (1), 16510872 (1)



    Find genes that share compounds with POU5F1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POU5F1 gene (5 alternative transcripts): 
    NM_001173531.2  NM_001285986.1  NM_001285987.1  NM_002701.5  NM_203289.5  

    Unigene Cluster for POU5F1:

    POU class 5 homeobox 1
    Hs.249184  [show with all ESTs]
    Unigene Representative Sequence: NM_203289
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441888 ENST00000259915(uc003nsv.3) ENST00000512818(uc021yuj.1)
    ENST00000606567 ENST00000513407(uc003nsu.3) ENST00000471529 ENST00000461401

    miRNA
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    Block miRNA regulation of human, mouse, rat POU5F1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate POU5F1:
    hsa-miR-3606 hsa-miR-3658 hsa-miR-103a-2* hsa-miR-3657 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidPOU5F1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat POU5F1
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    OriGene clones in human, mouse for POU5F1 (see all 16)
    OriGene ORF clones in mouse, rat for POU5F1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): POU5F1 (NM_002701)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for POU5F1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat POU5F1
    Addgene plasmids for POU5F1 
    Primer
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    OriGene qPCR primer pairs and template standards for POU5F1
    OriGene qSTAR qPCR primer pairs in human, mouse for POU5F1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POU5F1
      QuantiTect SYBR Green Assays in human, mouse, rat POU5F1
      QuantiFast Probe-based Assays in human, mouse, rat POU5F1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11760) for POU5F1 

    Additional mRNA sequence: 

    AM851115.1 AM851116.1 AM851117.1 AM851118.1 AM851119.1 AM851120.1 AM851121.1 AM851122.1 
    AM851123.1 AM851124.1 AM851125.1 AM851126.1 BC020712.1 BC069246.1 BC117435.1 BC117437.1 
    DQ486515.1 DQ486516.1 DQ486517.1 FM177951.1 FM177952.1 FM177953.1 FM177954.1 FM177955.1 
    FM177956.1 FM177957.1 FM177958.1 FM177959.1 FM177960.1 FM177961.1 FM177962.1 FM177963.1 
    FM177964.1 FM177965.1 FM177966.1 FM177967.1 FM177968.1 S81255.1 Z11898.1 Z11899.1 

    8 DOTS entries:

    DT.75142423  DT.100791936  DT.100018840  DT.102825540  DT.100791937  DT.121173762  DT.121322086  DT.75109570 

    9 AceView cDNA sequences:

    NM_203289 BC020712 Z11898 BC069246 Z11899 NM_002701 BF930231 BF871564 
    S81255 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    POU5F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCACTTTT
    POU5F1 Expression
    About this image


    POU5F1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 46) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 131 entries
             Inner Cell Mass Cells Inner Cell Mass
             CA2
             Matrigel embedded cells
             H1-GFP   
     
     Gonad
             Oogonia Ovigerous Cord
             Primordial germ-like cells
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 8 entries
             Primordial Germ Cell Precursors Epiblast
             Epiblast Stem Cells
             Epiblast-like cells
     
     Ovary (Reproductive System)    fully expand to see all 6 entries
             Oogonia Ovigerous Cord
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 6 entries
             Morula Cells Morula
    POU5F1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POU5F1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.249184

    UniProtKB/Swiss-Prot: PO5F1_HUMAN, Q01860
    Tissue specificity: Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the
    olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including POU5F1 (see all 6): 
              Cell Lineage Identification in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for POU5F1
    OriGene qSTAR qPCR primer pairs in human, mouse for POU5F1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat POU5F1
    QuantiTect SYBR Green Assays in human, mouse, rat POU5F1
    QuantiFast Probe-based Assays in human, mouse, rat POU5F1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POU5F1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for POU5F1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pou5f11 , 5 POU domain, class 5, transcription factor 11, 5 82.58(n)1
    84.66(a)1
      17 (18.69 cM)5
    189991  NM_013633.31  NP_038661.21 
     355060185 
    chicken
    (Gallus gallus)
    Aves POUV6
    Gallus gallus POU domain class 5 transcription fac...
    40(a)
    1 → many
    17(460123-461472)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    56(a)
    1 → many
    GL343623.1(305510-323263)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.232762 Xenopus laevis transcribed sequence with moderate similarity to protein pirS25561 (H.sapiens) S25561 transcription factor Oct-3, splice form Oct-3A - human less 80.05(n)    BQ900469.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pou5f12 POU domain, class 5, transcription factor 1 74.89(n)   30333  NM_131112.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta acj66
    abnormal chemosensory jump 6
    22(a)
    1 → many
    X(15245315-15272487)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-866
    Protein UNC-86, isoform a (unc-86) mRNA, complete ...
    26(a)
    1 → many
    III(8212758-8216336) WBGene00006818


    ENSEMBL Gene Tree for POU5F1 (if available)
    TreeFam Gene Tree for POU5F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POU5F1 gene
    POU5F22  POU6F22  POU4F22  POU2F32  POU3F12  POU3F42  POU1F12  POU3F32  
    POU4F32  POU3F22  POU2F22  POU5F1B2  POU4F12  POU2F12  POU6F12  
    14 SIMAP similar genes for POU5F1 using alignment to 53 protein entries:     PO5F1_HUMAN (see all proteins):
    POU5F1B    POU5F1P1    POU5F1P4    POU5F1P3    OCT6    POU2F3
    POU1F1    POU3F4    POU6F1    POU5F2    POU3F2    POU2F1
    POU2F2    POU3F1

    Find genes that share paralogs with POU5F1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for POU5F1 (see all 6)
    PGOHUM00000239313 PGOHUM00000245013 PGOHUM00000237756 PGOHUM00000238106 PGOHUM00000235313


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POU5F1 (see all 226)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs23948821,2
    C,F,A,H--31132649(+) CCTGCC/AAGTGA 3 -- int130Minor allele frequency- A:0.32NS EA NA WA CSA EU 4126
    rs92637951,2
    C,F,H--31132656(+) GTGAAT/CGACAG 3 -- int16Minor allele frequency- C:0.06EA NS NA EU 1607
    rs1919683711,2
    C,F--31132676(+) TGACAT/CTAGAC 3 -- int11Minor allele frequency- C:0.00EU 1063
    rs1827553761,2
    --31132710(+) CTGCTC/TGGACA 3 -- int10--------
    rs92637961,2
    C,F,H--31132883(+) GAGCCC/TGCAGA 3 -- int121Minor allele frequency- T:0.13NS EA NA WA CSA EU 3563
    rs178518181,2
    C,F--31132956(+) AGTGTG/CGGTTT 6 /P syn1 ese38Minor allele frequency- C:0.07NA EA WA EU 6766
    rs11507671,2,,4
    C,F,H--31133045(-) AAACCC/TTCGTG 6 L F mis1 ese310Minor allele frequency- T:0.03MN NS EA NA 922
    rs3682770841,2
    C--31133324(+) GTCCCC/TGGGTA 3 -- int10--------
    rs1152345111,2
    C,F--31133405(+) GGCCGC/AAGCTT 6 /L syn12Minor allele frequency- A:0.00WA NA 4448
    rs21060741,2
    C,F,O,A,H--31133509(-) CCTCAT/CTTTGC 3 -- int140Minor allele frequency- C:0.35EA NS NA WA CSA EU 5754

    HapMap Linkage Disequilibrium report for POU5F1 (31132114 - 31148508 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for POU5F1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731791CNV Deletion23290073
    nsv524061CNV Loss19592680
    nsv525933CNV Loss19592680
    nsv428140CNV Gain+Loss18775914
    esv690CNV CNV17122850
    dgv1919e1CNV Complex17122850
    dgv1918e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): POU5F1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POU5F1
    DNA2.0 Custom Variant and Variant Library Synthesis for POU5F1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164177    OMIM disorders: --

    9 diseases for POU5F1:    
    About MalaCards
    central nervous system germinoma    germinoma    seborrheic keratosis    pineoblastoma
    teratoma    sacrococcygeal teratoma    ovarian germ cell tumor    malignant germ cell tumor
    mixed germ cell tumor

    5 diseases from the University of Copenhagen DISEASES database for POU5F1:
    Teratoma     Gonadoblastoma     Embryonal carcinoma     Seminoma
    Dysgerminoma

    Find genes that share disorders with POU5F1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for POU5F1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 74.8 16 8662786 (2), 15725806 (1), 17314394 (1), 10328600 (1) (see all 13)
    teratoma 73.9 8 18439155 (1), 19826408 (1), 16494961 (1), 12161760 (1) (see all 8)
    pineoblastoma 46.3 1 15725806 (1)
    seminoma 44.6 4 15725806 (1), 17682839 (1), 17117392 (1)
    germinoma 36.7 6 15725806 (4), 17117392 (1)
    teratocarcinoma 33.4 1 8453995 (1)
    tumors 18 38 17205510 (5), 18701476 (3), 16510872 (3), 15513931 (2) (see all 22)
    cancer 17.3 23 17261754 (2), 16229821 (2), 16854382 (2), 18701476 (2) (see all 13)
    ewings sarcoma 16 3 15917470 (2), 20051954 (1), 17564582 (1)
    carcinoma 8.24 3 15342930 (1), 18614581 (1), 19876845 (1)

    Genetic Association Database (GAD): POU5F1
    Human Genome Epidemiology (HuGE) Navigator: POU5F1 (7 documents)

    Export disorders for POU5F1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POU5F1 gene, integrated from 10 sources (see all 540):
    (articles sorted by number of sources associating them with POU5F1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. (PubMed id 1408763)1, 2, 3, 9 Takeda J.... Bell G.I. (Nucleic Acids Res. 1992)
    2. Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. (PubMed id 18191611)1, 2, 9 Lee J.... Kim J. (Int. J. Biochem. Cell Biol. 2008)
    3. Oct4 pseudogenes are transcribed in cancers. (PubMed id 16229821)1, 2, 9 Suo G.... Dai J. (Biochem. Biophys. Res. Commun. 2005)
    4. A study of candidate genes for psoriasis near HLA-C in Chinese patients with psoriasis. (PubMed id 12653732)1, 4, 9 Chang Y.T....Wong C.K. (Br. J. Dermatol. 2003)
    5. Serine 111 phosphorylation regulates OCT4A protein subcellular distribution and degradation. (PubMed id 23024368)1, 2 Spelat R.... Curcio F. (J. Biol. Chem. 2012)
    6. Phosphorylation regulates human OCT4. (PubMed id 22474382)1, 2 Brumbaugh J.... Thomson J.A. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe. (PubMed id 21801394)1, 4 GAcnin E....Mockenhaupt M. (Orphanet J Rare Dis 2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    10. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5460 HGNC: 9221 AceView: POU5F1 Ensembl:ENSG00000204531 euGenes: HUgn5460
    ECgene: POU5F1 H-InvDB: POU5F1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POU5F1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Oct-4

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POU5F1 gene:
    Search GeneIP for patents involving POU5F1

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Cell Lines for POU5F1: Human Embryonic Stem Cell Line ESI-017, Human Embryonic Stem Cell Line ESI-035,
    Human Embryonic Stem Cell Line ESI-049, Human Embryonic Stem Cell Line ESI-051,
    Human Embryonic Stem Cell Line ESI-053
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     Addgene plasmids for POU5F1
      Search eBioscience for proteins for POU5F1
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      eBioscience FlowRNA Probe Sets
           
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